CN101301389A - Chinese medicinal composition for treating mammilla and lacteal cistern neoplasm disease of milk cattle and preparation and use thereof - Google Patents
Chinese medicinal composition for treating mammilla and lacteal cistern neoplasm disease of milk cattle and preparation and use thereof Download PDFInfo
- Publication number
- CN101301389A CN101301389A CNA2008101326027A CN200810132602A CN101301389A CN 101301389 A CN101301389 A CN 101301389A CN A2008101326027 A CNA2008101326027 A CN A2008101326027A CN 200810132602 A CN200810132602 A CN 200810132602A CN 101301389 A CN101301389 A CN 101301389A
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- filtrate
- chinese medicine
- standby
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 31
- 235000013336 milk Nutrition 0.000 title claims abstract description 25
- 239000008267 milk Substances 0.000 title claims abstract description 25
- 210000004080 milk Anatomy 0.000 title claims abstract description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 24
- 241000283690 Bos taurus Species 0.000 title claims description 27
- 241000780272 Mammilla Species 0.000 title claims description 21
- 206010028980 Neoplasm Diseases 0.000 title claims description 17
- 208000035269 cancer or benign tumor Diseases 0.000 title claims description 17
- 238000002360 preparation method Methods 0.000 title claims description 12
- 239000003814 drug Substances 0.000 claims abstract description 79
- 241000746375 Andrographis Species 0.000 claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 75
- 239000000706 filtrate Substances 0.000 claims description 56
- 239000007788 liquid Substances 0.000 claims description 52
- 239000004744 fabric Substances 0.000 claims description 20
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 238000009835 boiling Methods 0.000 claims description 16
- 238000007599 discharging Methods 0.000 claims description 16
- 241000628997 Flos Species 0.000 claims description 14
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 14
- 239000010231 banlangen Substances 0.000 claims description 13
- 238000002347 injection Methods 0.000 claims description 13
- 239000007924 injection Substances 0.000 claims description 13
- 239000000243 solution Substances 0.000 claims description 13
- 238000000605 extraction Methods 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 10
- 241000219295 Portulaca Species 0.000 claims description 7
- 241000405217 Viola <butterfly> Species 0.000 claims description 7
- 238000012856 packing Methods 0.000 claims description 6
- 238000011084 recovery Methods 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 239000006200 vaporizer Substances 0.000 claims description 6
- 229910052573 porcelain Inorganic materials 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 5
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 239000008280 blood Substances 0.000 abstract description 15
- 210000004369 blood Anatomy 0.000 abstract description 15
- 238000000034 method Methods 0.000 abstract description 8
- 210000002445 nipple Anatomy 0.000 abstract description 8
- 201000010099 disease Diseases 0.000 abstract description 7
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 208000002193 Pain Diseases 0.000 abstract description 3
- 230000017531 blood circulation Effects 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 230000003213 activating effect Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 abstract 1
- 241000758794 Asarum Species 0.000 abstract 1
- 241000218176 Corydalis Species 0.000 abstract 1
- 235000013717 Houttuynia Nutrition 0.000 abstract 1
- 240000000691 Houttuynia cordata Species 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 241000334160 Isatis Species 0.000 abstract 1
- 241000334154 Isatis tinctoria Species 0.000 abstract 1
- 244000234609 Portulaca oleracea Species 0.000 abstract 1
- 235000001855 Portulaca oleracea Nutrition 0.000 abstract 1
- 241001278833 Rosa laevigata Species 0.000 abstract 1
- 235000000661 Rosa laevigata Nutrition 0.000 abstract 1
- 241000612118 Samolus valerandi Species 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 241001674034 Stephanotis Species 0.000 abstract 1
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000006651 lactation Effects 0.000 abstract 1
- 230000002175 menstrual effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 19
- 229940079593 drug Drugs 0.000 description 12
- 231100000614 poison Toxicity 0.000 description 10
- 239000003440 toxic substance Substances 0.000 description 10
- 206010007247 Carbuncle Diseases 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 6
- 201000007227 lymph node tuberculosis Diseases 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 206010035664 Pneumonia Diseases 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 5
- 238000010255 intramuscular injection Methods 0.000 description 5
- 239000007927 intramuscular injection Substances 0.000 description 5
- 238000011161 development Methods 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 208000001780 epistaxis Diseases 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 201000000297 Erysipelas Diseases 0.000 description 3
- 206010017553 Furuncle Diseases 0.000 description 3
- 206010023126 Jaundice Diseases 0.000 description 3
- 206010068319 Oropharyngeal pain Diseases 0.000 description 3
- 201000007100 Pharyngitis Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 238000010253 intravenous injection Methods 0.000 description 3
- 230000003211 malignant effect Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 230000001047 pyretic effect Effects 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 208000006400 Arbovirus Encephalitis Diseases 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 2
- 208000004429 Bacillary Dysentery Diseases 0.000 description 2
- 206010010741 Conjunctivitis Diseases 0.000 description 2
- 206010052369 Encephalitis lethargica Diseases 0.000 description 2
- 206010060710 Galactostasis Diseases 0.000 description 2
- 208000005577 Gastroenteritis Diseases 0.000 description 2
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 2
- 206010020880 Hypertrophy Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 206010001093 acute tonsillitis Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 201000001352 cholecystitis Diseases 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 208000014617 hemorrhoid Diseases 0.000 description 2
- 201000003453 lung abscess Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 201000005113 shigellosis Diseases 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 239000002435 venom Substances 0.000 description 2
- 231100000611 venom Toxicity 0.000 description 2
- 210000001048 venom Anatomy 0.000 description 2
- 201000002498 viral encephalitis Diseases 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000037319 Hepatitis infectious Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 241000245240 Lonicera Species 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000004680 Rectal Fistula Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 201000004484 acute conjunctivitis Diseases 0.000 description 1
- 208000012873 acute gastroenteritis Diseases 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 206010002156 anal fistula Diseases 0.000 description 1
- 235000020244 animal milk Nutrition 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 201000003265 lymphadenitis Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 201000002266 mite infestation Diseases 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 210000003300 oropharynx Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to Chinese medicine composition for treating the excrescence disease of cisterns of nipples of a milk cow. The composition is prepared by the following Chinese medicine materials of heartleaf houttuynia herb, bunge corydalis herb, dandelion, uniflower swisscentaury root, dyers woad leaf, isatis root, purslane, cherokee rose flower, common andrographis herb, stephanotis and lightyellow sophora root. The invention also relates to a method for preparing the composition and an application of the composition. The composition has the advantages of clearing away heat and toxic material, activating blood circulation to dissipate blood stasis, promoting menstrual flow and activating collateral flow, diminishing inflammation and relieving pain and, reducing swells and promoting lactation, resolving difficult and baffling diseases of nipples of the milk cow which can not be completely cured by means of medicine or operation for decades and having obvious medical values, economic benefits and social benefits.
Description
Technical field
The present invention relates to from natural Chinese medicinal herb, decoct the brown transparency liquid that extracts through High Temperature High Pressure, has heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, anti-inflammatory analgetic, the effect of detumescence lactogenesis is used for the treatment of the mammary duct obstruction of the superfluous thing of animal milk head vat such as milch cow due to stopping up, milk is discharged Chinese medicine composition of the medicine that is obstructed and preparation method thereof, also relates to the application of said composition in preparation mammilla and lacteal cistern neoplasm disease of milk cattle medicine.
Background technology
Mammilla of milk cattle breast pond vegetation is stopped up (nipple breast pond hypertrophy rhabdion) causes nipple breast pond all to block.Make ill nipple lose the development of this disease of physiological action (blind nipple) along with milch cow, sickness rate is increasing, and the therapeutic effect that ins all sorts of ways is all undesirable, and this disease has seriously hindered the development of dairy.
Adopt the means of Chinese medicine to treat mammilla and lacteal cistern neoplasm disease of milk cattle, it is a channel extremely leaved for development, this is because therefore Chinese medicine characteristics such as to have the property of medicine gentle, applied widely are having its original effect aspect the mammilla and lacteal cistern neoplasm disease of milk cattle treatment.
Summary of the invention
An object of the present invention is to provide a kind of Chinese medicine composition for the treatment of mammilla and lacteal cistern neoplasm disease of milk cattle, said composition is prepared from by following Chinese medicine raw materials by weight proportion:
5～15 parts of Herba Houttuyniae, 5～15 parts of Herba Violaes, 5～15 parts of Herba Taraxacis, 5～15 parts of Radix Rhapontici, 5～15 parts of Folium Isatidiss, 5～15 parts of Radix Isatidis, 5～15 parts of Herba Portulacaes, 3～8 parts of Flos Rosae Laevigataes, 3～8 parts of Herba Andrographis, 3～8 parts of Radix Stephaniae Cepharanthaes, 3～8 parts of Radix Sophorae Flavescentiss.
Preferably, said composition is prepared from by following Chinese medicine raw materials by weight proportion:
10 parts of Herba Houttuyniae, 10 parts of Herba Violaes, 10 parts of Herba Taraxacis, 10 parts of Radix Rhapontici, 10 parts of Folium Isatidiss, 10 parts of Radix Isatidis, 10 parts of Herba Portulacaes, 5 parts of Flos Rosae Laevigataes, 5 parts of Herba Andrographis, 5 parts of Radix Stephaniae Cepharanthaes, 5 parts of Radix Sophorae Flavescentiss.
Chinese medicine composition of the present invention can be made various types of pharmaceutical preparatioies according to actual needs, for example makes oral liquid or injection, and is preferred but be not limited to oral liquid.In order to prepare these preparations, can in compositions of the present invention, add conventional pharmaceutically acceptable auxiliaries as required, selection for adjuvant, those skilled in the art can carry out according to the requirement of dosage form, when for example preparing oral liquid, in the present composition, can add sweeting agent, flavoring agent and antiseptic.For the concrete selection of adjuvant, the present invention's specific restriction useless.
Another object of the present invention provides a kind of preparation method of the present composition, and this method may further comprise the steps:
With above Herba Houttuyniae, Herba Violae, Herba Taraxaci, Radix Rhapontici, Folium Isatidis, Radix Isatidis, Herba Portulacae, Flos Rosae Laevigatae, Herba Andrographis, Radix Stephaniae Cepharanthae, Radix Sophorae Flavescentis ten simply raw material of Chinese medicine clean, dry, weigh by weight ratio, wash, place and add water 5-10 in the High Temperature High Pressure boiling machine and doubly measure, under 1.5～2.0 pounds of vapour pressures, heat and boiled medicine 40-60 minute, the discharging medicinal liquid, filter by two-layer husky cloth, win time filtrate is standby;
2. for the second time add water 3-5 in the High Temperature High Pressure boiling machine and doubly measure, heat under 1.5～2.0 pounds of vapour pressures and boiled medicine 20-40 minute, the discharging medicinal liquid filters by two-layer husky cloth, gets filtrate for the second time, and is standby;
3. add water 1-2 for the third time and doubly measure in the High Temperature High Pressure boiling machine, soaked 10-20 minute at normal temperature and pressure, the discharging medicinal liquid filters by two-layer husky cloth, gets filtrate for the third time, and is standby;
4. first time that above step 1, step 2, step 3 is standby, for the second time, filtrate places container to mix for the third time, precipitation is filtered, filtrate, standby;
5. step 4 gained filtrate is concentrated with the Chinese medicine vaporizer, concentrated concentration is 1/10th of filtrate, gets concentrated solution, and is standby;
6, step 5 gained concentrated solution is added the ethanol of 3 times of amount ethanol contents 95%, room temperature left standstill 24-36 hour, supernatant porcelain rod sucking filtration, and medicinal residues hang filter with cloth bag, and merging filtrate gets ethanol and mixes filtrate, and is standby;
7, step 6 gained ethanol is mixed filtrate and reclaim ethanol with alcohol recovering device, the filtrate behind the recovery ethanol promptly gets Chinese medicine extraction liquid with filter paper or micro-pore-film filtration, and is standby;
8, step 7 gained Chinese medicine extraction liquid is regulated pH value to 7.0 with sodium hydroxide, and unit of adjustment's total amount is to 1000ml, embedding, sterilization, packing promptly gets qualified Chinese medicine composition.
Subsequently, can preparation of compositions of the present invention be become various dosage forms according to the ordinary skill in the art.For example get above standby filtrate, can add flavoring agent and/or antiseptic if desired, regulate pH value to 7.0 with sodium hydroxide, and unit of adjustment's total amount, embedding, sterilization, packing promptly gets oral liquid of the present invention.
Described High Temperature High Pressure boiling machine is the High Temperature High Pressure boiling machine of being made by Shandong Province's Qingzhou City absolute sincerity machine-building company limited.
Described Chinese medicine vaporizer is the Chinese medicine vaporizer of being made by device fabrication company limited in the river, Jiangyin City, Jiangsu Province.
Described alcohol recovering device is the alcohol recovering device of being made by Wuxi City, Jiangsu Province Haidah chemical machinery company limited.
Described ethanol is the medical ethanol that meets national standard.
Described water is the tap water that meets national standard for drinking.
Above-mentioned raw material and equipment are all commercially available to be arrived.
Need to prove that method of the present invention is a kind of preferable preparation technique but is not limited to this.Product by the inventive method preparation has good stability.
For many years, adopt Chinese medicine composition of the present invention, particularly the oral liquid treatment mammilla and lacteal cistern neoplasm disease of milk cattle obtains better curative effect, does not see any toxic and side effects.
The present invention distinguishes the theory of Chinese medical science that disease executing controlled according to Chinese veterinarian, its prescription has heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, anti-inflammatory analgetic, the effect of detumescence lactogenesis has solved the mammilla of milk cattle difficult and complicated illness that medicine in decades or operation all can not thoroughly be cured, and has significant medical value, economic benefit and a social benefit.Promoted the development of dairy.In the Chinese medicine composition prescription of the present invention: Herba Houttuyniae, Herba Violae, Herba Taraxaci, Radix Rhapontici, Folium Isatidis, Radix Isatidis, Herba Portulacae are principal agent; effect with heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Flos Rosae Laevigatae, Herba Andrographis, Radix Stephaniae Cepharanthae, Radix Sophorae Flavescentis have anti-inflammatory analgetic, removing food stagnancyization stagnates; impel the atrophy of hypertrophy fibrohistiocytic to absorb, disease is eliminated the effect of recovering normal.
In the prescription of treatment mammilla and lacteal cistern neoplasm disease of milk cattle of the present invention: put down in writing according to the Chinese medicine voluminous dictionary:
Herba Houttuyniae-[function cures mainly]: heat-clearing and toxic substances removing, inducing diuresis to remove edema; Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.
Herba Violae---[function cures mainly]: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling; Control furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom.
Herba Taraxaci---[function cures mainly]: heat-clearing and toxic substances removing, diuresis eliminating stagnation; Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.
Radix Rhapontici---[function cures mainly]: heat-clearing and toxic substances removing, detumescence and apocenosis, stimulating milk secretion, logical muscle arteries and veins; Control the carbuncle carbuncle on the back, breast swell and pain, galactostasis, scrofula malignant boil, the contracture of arthralgia chiefly caused by damp pathogen muscle arteries and veins, arthralgia, toxic-heat and blood stasis, bleeding hemorrhoids.
Folium Isatidis---[function cures mainly]: heat clearing away, detoxifcation, removing heat from blood, hemostasis; Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas is spitted blood epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.
Radix Isatidis---[function cures mainly]: heat clearing away, detoxifcation, removing heat from blood; Control influenza, epidemic encephalitis, encephalitis b, pneumonia, erysipelas, pyretic toxicity is sent out speckle, and coma is told nosebleed, pharyngeal swelling, mumps, acute catarrhal conjunctivitis, skin ulcer rash.
Herba Portulacae---[function cures mainly]: heat-clearing and toxic substances removing, the blood detumescence of loosing; Control the hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, scrofula.
Flos Rosae Laevigatae---[function cures mainly]: end cold and hot dysentery, kill cun white, ascarid etc.
Herba Andrographis---[function cures mainly]: heat-clearing and toxic substances removing, removing heat from blood detumescence; Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.
Radix Stephaniae Cepharanthae---[function cures mainly]: heat clearing away expectorant, removing pathogenic heat from blood and toxic substance from the body, pain relieving; Control the pharyngalgia sore throat, cough is spitted blood, epistaxis, and gold is created blood, pyretic toxicity carbuncle, scrofula.
Radix Sophorae Flavescentis---[function cures mainly]: heat clearing away, dampness, parasite killing; Control toxic-heat and blood stasis, discharging fresh blood stool, jaundice, leucorrhea with red and white discharge, infantile pneumonia, infantile malnutrition, acute tonsillitis, anal fistula, proctoptosis, skin pruritus, the mange malignant boil, erosion of vulva pruritus due to damp pathogen, scrofula is scalded.
With the medical material in the above-mentioned prescription by weight ratio complex group fit over together, have following effect:
1, pure Chinese medicinal preparation, pure green medicine, the prescription novelty, rationally, have no side effect, raw material sources are extensive, cost is low.2, medication once can be cured, and does not need the secondary medication, and is convenient easy-to-use, reduces the trouble of repeatedly medication.3, curative effect is outstanding, and effect is remarkable, dosage is little, the medication number of times is few, and cost is low, short treating period, and instant effect, clinical use 3 years suffers from mammilla and lacteal cistern neoplasm disease of milk cattle Niu Tongji to 2620 and all cures, and effective percentage is absolutely.
For this reason, another object of the present invention provides the application of a kind of present composition in preparation mammilla and lacteal cistern neoplasm disease of milk cattle medicine.
Description of drawings
Accompanying drawing is preparation technology's flow chart of oral liquid of the Chinese medicine composition of invention.
The specific embodiment
Embodiment 1
Oral liquid:
1. with Herba Houttuyniae, Herba Violae, Herba Taraxaci, Radix Rhapontici, Folium Isatidis, Radix Isatidis, Herba Portulacae, Flos Rosae Laevigatae, Herba Andrographis, Radix Stephaniae Cepharanthae, Radix Sophorae Flavescentis ten is the dried medicine of raw material of Chinese medicine simply, clean 10 kilograms of the Herba Houttuyniae of weighing by weight ratio, 10 kilograms of Herba Violaes, 10 kilograms of Herba Taraxacis, 10 kilograms of Radix Rhapontici, 10 kilograms of Folium Isatidiss, 10 kilograms of Radix Isatidis, 10 kilograms of Herba Portulacaes, 5 kilograms of Flos Loniceraes, 5 kilograms of Herba Andrographis, 5 kilograms of Radix Stephaniae Cepharanthaes, 5 kilograms of Radix Sophorae Flavescentiss, washing, place and add 630 kilograms in water (7 times of amounts) in the High Temperature High Pressure boiling machine, under 1.5 pounds of vapour pressures, heat and boiled medicine 50 minutes, the discharging medicinal liquid, medicinal liquid is filtered by two-layer husky cloth, win time filtrate is standby;
2. for the second time add 360 kilograms in water (4 times of amounts) in the High Temperature High Pressure boiling machine, heat under 1.5 pounds of vapour pressures and boiled medicine 40 minutes, the discharging medicinal liquid filters medicinal liquid by two-layer husky cloth, get filtrate for the second time, and is standby;
3. add 180 kilograms in water (2 times of amounts) for the third time in the High Temperature High Pressure boiling machine, soaked 15 minutes at normal temperature and pressure, the discharging medicinal liquid filters medicinal liquid by two-layer husky cloth, get filtrate for the third time, and is standby;
4. first time that above step 1, step 2, step 3 is standby, for the second time, filtrate merging places container to mix for the third time, precipitation is filtered, filtrate, standby;
5. step 4 gained filtrate is concentrated with the Chinese medicine vaporizer, concentrated concentration is 1/10th of filtrate, gets concentrated solution, and is standby;
6, step 5 gained concentrated solution is added the ethanol of 3 times of amount ethanol contents 95%, room temperature left standstill 24 hours, supernatant porcelain rod sucking filtration, and medicinal residues hang filter with cloth bag, and merging filtrate gets ethanol and mixes filtrate, and is standby;
7, step 6 gained ethanol is mixed filtrate and reclaim ethanol with alcohol recovering device, the filtrate behind the recovery ethanol promptly gets Chinese medicine extraction liquid with filter paper or micro-pore-film filtration, and is standby;
8, step 7 gained Chinese medicine extraction liquid is regulated pH value to 7.0 with sodium hydroxide, and unit of adjustment's total amount is to 1000ml, embedding, sterilization, packing, promptly.
Character: this product is brown transparency liquid; Gas perfume (or spice), puckery, little hardship.
Differentiate: get this product 200ml, put in the round-bottomed flask, connect condensing tube (should be short and small) heating and be distilled to about 1 minute of boiling, when treating that crystallization appears in the condensing tube inwall, withdraw thermal source immediately, collect agglomerative crystallization on distillate (about 2-3ml) and the condensing tube inwall.
(1) it is an amount of to take by weighing the crystallization of separating out, and adds ethanol and makes dissolving, and make the solution that every 1ml contains 2.5mg, as need testing solution.According to ultraviolet-visible spectrophotometer method (appendix VA of Chinese Pharmacopoeia version in 2005) test, be blank with ethanol.Measure absorption curve between wavelength 230-350nm, its absorption curve should be consistent with the absorption curve of Herba Houttuyniae reference substance solution (1ml contains 2.5ml), at wavelength 289 ± 1nm place one maximum absorption band should be arranged.
(2) getting this product distillate, according to ultraviolet visible spectrophotometry (appendix VA of Chinese Pharmacopoeia version in 2005) test, is blank with water.Wavelength place at wavelength 250-350nm measures absorption curve, at 277 ± 1nm place, a maximum absorption band should be arranged.
Check: relative density should be not less than 0.9 (an appendix VII of Chinese Pharmacopoeia version in 2005 A).
PH value should be 5.5-7.5 (an appendix VII of Chinese Pharmacopoeia version in 2005 G).
Other should meet every regulation relevant under the mixture item (appendix IJ of Chinese Pharmacopoeia version in 2005).
Usage and consumption: oral liquid, a 100-200 milliliter, 2-3 time on the one, or follow the doctor's advice.
Embodiment 2
Oral liquid:
1. with Herba Houttuyniae, Herba Violae, Herba Taraxaci, Radix Rhapontici, Folium Isatidis, Radix Isatidis, Herba Portulacae, Flos Rosae Laevigatae, Herba Andrographis, Radix Stephaniae Cepharanthae, Radix Sophorae Flavescentis ten raw material of Chinese medicine simply cleans, dry, weigh by weight ratio 10 kilograms of Herba Houttuyniae, 5 kilograms of Herba Violaes, 5 kilograms of Herba Taraxacis, 6 kilograms of Radix Rhapontici, 6 kilograms of Folium Isatidiss, 8 kilograms of Radix Isatidis, 10 kilograms of Herba Portulacaes, 3 kilograms of Flos Rosae Laevigataes, 8 kilograms of Herba Andrographis, 3 kilograms of Radix Stephaniae Cepharanthaes, 5 kilograms of Radix Sophorae Flavescentiss, washing, place and add 690 kilograms in water (10 times of amounts) in the High Temperature High Pressure boiling machine, under 13 pounds of vapour pressures, heat and boiled medicine 60 minutes, the discharging medicinal liquid, medicinal liquid is filtered by two-layer husky cloth, win time filtrate is standby;
2. for the second time add 207 kilograms in water (3 times of amounts) in the High Temperature High Pressure boiling machine, heat under 1.5 pounds of vapour pressures and boiled medicine 30 minutes, the discharging medicinal liquid filters medicinal liquid by two-layer husky cloth, get filtrate for the second time, and is standby;
3. add 103 kilograms in water (1.5 times of amounts) for the third time in High Temperature High Pressure is boiled medicine filling, soaked 20 minutes at normal temperature and pressure, the discharging medicinal liquid filters medicinal liquid by two-layer husky cloth, get filtrate for the third time, and is standby;
4. first time that above step 1, step 2, step 3 is standby, for the second time, filtrate merging places container to mix for the third time, precipitation is filtered, filtrate, standby;
5. step 4 gained filtrate is concentrated with membrane evaporator, concentrated concentration is 1/10th of filtrate, gets concentrated solution, and is standby;
6, step 5 gained concentrated solution is added the ethanol of 3 times of amount ethanol contents 95%, room temperature left standstill 30 hours, supernatant porcelain rod sucking filtration, and medicinal residues hang filter with cloth bag, and merging filtrate gets ethanol and mixes filtrate, and is standby;
7, step 6 gained ethanol is mixed filtrate and reclaim ethanol with alcohol recovering device, the filtrate behind the recovery ethanol promptly gets Chinese medicine extraction liquid with filter paper or micro-pore-film filtration, and is standby;
8, with step 7 gained Chinese medicine extraction liquid, add an amount of sucrose dissolved, regulate pH value to 7.0, and unit of adjustment's total amount is to 1000ml with sodium hydroxide, embedding, sterilization, packing, promptly.
Usage and consumption: oral liquid, a 100-200 milliliter once-a-day, or is followed the doctor's advice.
Embodiment 3
Injection:
1. with Herba Houttuyniae, Herba Violae, Herba Taraxaci, Radix Rhapontici, Folium Isatidis, Radix Isatidis, Herba Portulacae, Flos Rosae Laevigatae, Herba Andrographis, Radix Stephaniae Cepharanthae, Radix Sophorae Flavescentis ten raw material of Chinese medicine simply cleans, dry, weigh by weight ratio 15 kilograms of Herba Houttuyniae, 12 kilograms of Herba Violaes, 10 kilograms of Herba Taraxacis, 10 kilograms of Radix Rhapontici, 10 kilograms of Folium Isatidiss, 12 kilograms of Radix Isatidis, 15 kilograms of Herba Portulacaes, 5 kilograms of Flos Rosae Laevigataes, 8 kilograms of Herba Andrographis, 3 kilograms of Radix Stephaniae Cepharanthaes, 8 kilograms of Radix Sophorae Flavescentiss, washing, place and add 648 kilograms in water (6 times of amounts) in the High Temperature High Pressure boiling machine, under 2.0 pounds of vapour pressures, heat and boiled medicine 40 minutes, the discharging medicinal liquid, medicinal liquid is filtered by two-layer husky cloth, win time filtrate is standby;
2. for the second time add 432 kilograms in water (4 times of amounts) in the High Temperature High Pressure boiling machine, heat under 1.5 pounds of vapour pressures and boiled medicine 30 minutes, the discharging medicinal liquid filters medicinal liquid by two-layer husky cloth, get filtrate for the second time, and is standby;
3. add 108 kilograms in water (1 times of amount) for the third time in High Temperature High Pressure is boiled medicine filling, soaked 20 minutes at normal temperature and pressure, the discharging medicinal liquid filters medicinal liquid by two-layer husky cloth, get filtrate for the third time, and is standby;
4. first time that above step 1, step 2, step 3 is standby, for the second time, filtrate merging places container to mix for the third time, precipitation is filtered, filtrate, standby;
5. step 4 gained filtrate is concentrated with the Chinese medicine vaporizer, concentrated concentration is 1/10th of filtrate, gets concentrated solution, and is standby;
6, step 5 gained concentrated solution is added the ethanol of 3 times of amount ethanol contents 95%, room temperature left standstill 48 hours, supernatant porcelain rod sucking filtration, and medicinal residues hang filter with cloth bag, and merging filtrate gets ethanol and mixes filtrate, and is standby;
7, step 6 gained ethanol is mixed filtrate and reclaim ethanol with alcohol recovering device, the filtrate behind the recovery ethanol promptly gets Chinese medicine extraction liquid with filter paper or micro-pore-film filtration, and is standby;
8, with step 7 gained Chinese medicine extraction liquid, regulate pH value to 7.0 with sodium hydroxide, and unit of adjustment's total amount is to 1000ml, embedding, sterilization, packing, promptly.
Usage and consumption: injection, a 30-40 milliliter once-a-day, or is followed the doctor's advice.
Embodiment 4
The test of pesticide effectiveness:
1, is used for the treatment of the test of " mammilla of milk cattle breast pond vegetation ", A test method: get trouble " nipple breast pond vegetation " and suffer from 10 injection local injections of using the embodiment of the invention 3 of cattle, be that disposable injection was observed 15～20 days the whole course of treatment, and 10 superfluous things of ill nipple are given birth to the recovery from illness that all disappears.
Matched group: other gets the trouble cattle of 10 " trouble mammilla and lacteal cistern neoplasm disease of milk ", uses other medicines or operation method and cures the disease, and 20% temporary alleviation is arranged, and 80% fails to respond to any medical treatment.
Embodiment 5
The poison of medicine is secondary to be tested:
20 milliliters of consumption intramuscular injection of get 10 healthy cows, using the injection of the embodiment of the invention 3, continuous use 10 days, injection every day once, there is not a head of cattle that untoward reaction is arranged, all are normal, this illustrates that this medicine is safely, has no side effect, the excrescent curative in mammilla of milk cattle breast pond evident in efficacy---the logical injection of breast plug.
Use usage and the consumption and the effect table of various dosage forms " treating the oral liquid or the injection of mammilla and lacteal cistern neoplasm disease of milk cattle " to treating 2620 sick cattle statistics of suffering from mammilla and lacteal cistern neoplasm disease of milk:
Experimental result shows the using method dosage form, and consumption has substantial connection, and the muscle effect is better than intravenous injection, it is better that consumption is pressed high dose medication effect, and consumption is by middle low dosage medication, and effect is a little low, the effect and the intramuscular injection of oral liquid penetrated, the effect of quiet injection is hanged down than all, and the course of treatment is longer.From this medicinal medicine approach optimum efficiency of above description of test is local intramuscular injection, secondly is intravenous administration, intramuscular injection, dosage: be by dosage medication better effects if higher in the positive usual amounts.
Best usage and dosage is: the intramuscular injection milch cow ampoule 40ml that grows up, fully recovered after the medication in 5-6 days.
The intravenous injection effect is effective not as local injection, and Baoding trouble poultry difficulty is big, and disposal technology requires high, so intravenous injection is not first-selected Therapeutic Method.
The oral liquid medication is convenient, does not have veterinary's disposal technology, all can use, and usage is easy, and everybody can both medication, and oral liquid is popular drug formulation.
More than embodiments of the invention are had been described in detail, but described content only is preferred embodiment of the present invention, can not be considered to be used to limit practical range of the present invention.All equalizations of doing according to the present patent application scope change and improve etc., all should still belong within the patent covering scope of the present invention.
Claims (4)
1, a kind of Chinese medicine composition for the treatment of mammilla and lacteal cistern neoplasm disease of milk cattle, said composition is prepared from by following Chinese medicine raw materials by weight proportion:
5～15 parts of Herba Houttuyniae, 5～15 parts of Herba Violaes, 5～15 parts of Herba Taraxacis, 5～15 parts of Radix Rhapontici, 5～15 parts of Folium Isatidiss, 5～15 parts of Radix Isatidis, 5～15 parts of Herba Portulacaes, 3～8 parts of Flos Rosae Laevigataes, 3～8 parts of Herba Andrographis, 3～8 parts of Radix Stephaniae Cepharanthaes, 3～8 parts of Radix Sophorae Flavescentiss.
2, a kind of Chinese medicine composition for the treatment of mammilla and lacteal cistern neoplasm disease of milk cattle according to claim 1, it is characterized in that: said composition is prepared from by following Chinese medicine raw materials by weight proportion:
10 parts of Herba Houttuyniae, 10 parts of Herba Violaes, 10 parts of Herba Taraxacis, 10 parts of Radix Rhapontici, 10 parts of Folium Isatidiss, 10 parts of Radix Isatidis, 10 parts of Herba Portulacaes, 5 parts of Flos Rosae Laevigataes, 5 parts of Herba Andrographis, 5 parts of Radix Stephaniae Cepharanthaes, 5 parts of Radix Sophorae Flavescentiss.
3, according to the Chinese medicine composition of the described any one group of treatment mammilla and lacteal cistern neoplasm disease of milk cattle of claim 1-2, it is characterized in that: described compositions is oral liquid or injection.
4, according to the described any one group of preparation method for the treatment of the Chinese medicine composition of mammilla and lacteal cistern neoplasm disease of milk cattle of claim 1-2, it is characterized in that:
1). with above Herba Houttuyniae, Herba Violae, Herba Taraxaci, Radix Rhapontici, Folium Isatidis, Radix Isatidis, Herba Portulacae, Flos Rosae Laevigatae, Herba Andrographis, Radix Stephaniae Cepharanthae, Radix Sophorae Flavescentis ten simply the dried medicine of Chinese medicine, clean, weigh by weight ratio, wash, place and add water 5-10 in the High Temperature High Pressure boiling machine and doubly measure, under 1.5～2.0 pounds of vapour pressures, heat and boiled medicine 40-60 minute, the discharging medicinal liquid, filter by two-layer husky cloth, win time filtrate is standby;
2). add water 3-5 for the second time and doubly measure in the High Temperature High Pressure boiling machine, heat under 1.5～2.0 pounds of vapour pressures and boiled medicine 20-40 minute, the discharging medicinal liquid filters by two-layer husky cloth, gets filtrate for the second time, and is standby;
3). add water 1-2 for the third time and doubly measure in the High Temperature High Pressure boiling machine, soaked 10-20 minute at normal temperature and pressure, the discharging medicinal liquid filters by two-layer husky cloth, gets filtrate for the third time, and is standby;
4). with step 1), step 2), step 3) standby first time, for the second time, filtrate places container to mix for the third time, precipitation is filtered, filtrate, standby;
5). step 4) gained filtrate is concentrated with the Chinese medicine vaporizer, and concentrated concentration is 1/10th of filtrate, gets concentrated solution, and is standby;
6). step 5) gained concentrated solution is added 3 times of ethanol of measuring ethanol contents 95%, and room temperature left standstill 24-48 hour, supernatant porcelain rod sucking filtration, medicinal residues hang filter with cloth bag, and merging filtrate gets ethanol and mixes filtrate, and is standby;
7). step 6) gained ethanol is mixed filtrate reclaim ethanol with alcohol recovering device, the filtrate behind the recovery ethanol promptly gets Chinese medicine extraction liquid with filter paper or micro-pore-film filtration, and is standby;
8). step 7) gained Chinese medicine extraction liquid is regulated pH value to 7.0 with sodium hydroxide, and unit of adjustment's total amount is to 1000ml, embedding, sterilization, packing promptly gets qualified Chinese medicine composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101326027A CN101301389B (en) | 2008-07-07 | 2008-07-07 | Chinese medicinal composition for treating mammilla and lacteal cistern neoplasm disease of milk cattle and preparation and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101326027A CN101301389B (en) | 2008-07-07 | 2008-07-07 | Chinese medicinal composition for treating mammilla and lacteal cistern neoplasm disease of milk cattle and preparation and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101301389A true CN101301389A (en) | 2008-11-12 |
| CN101301389B CN101301389B (en) | 2010-10-13 |
Family
ID=40111605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101326027A Expired - Fee Related CN101301389B (en) | 2008-07-07 | 2008-07-07 | Chinese medicinal composition for treating mammilla and lacteal cistern neoplasm disease of milk cattle and preparation and use thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101301389B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101983584A (en) * | 2010-12-01 | 2011-03-09 | 中国科学院东北地理与农业生态研究所 | Additive for improving dry matter intake of dairy cow feed in early lactation |
| CN103405686A (en) * | 2013-09-09 | 2013-11-27 | 济南春季生物科技有限公司 | Medicine-food lactation promoting soup and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1315513C (en) * | 2004-11-18 | 2007-05-16 | 西北农林科技大学 | Traditional Chinese medicine powder for treating mastitis of dairy cattle |
-
2008
- 2008-07-07 CN CN2008101326027A patent/CN101301389B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101983584A (en) * | 2010-12-01 | 2011-03-09 | 中国科学院东北地理与农业生态研究所 | Additive for improving dry matter intake of dairy cow feed in early lactation |
| CN101983584B (en) * | 2010-12-01 | 2013-02-27 | 中国科学院东北地理与农业生态研究所 | Additive for improving dry matter intake of dairy cow feed in early lactation |
| CN103405686A (en) * | 2013-09-09 | 2013-11-27 | 济南春季生物科技有限公司 | Medicine-food lactation promoting soup and preparation method thereof |
| CN103405686B (en) * | 2013-09-09 | 2015-01-14 | 济南春季生物科技有限公司 | Medicine-food lactation promoting soup and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101301389B (en) | 2010-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102205026B (en) | Chinese medicinal composition for treating children chronic sinusitis and preparation method thereof | |
| CN103751812A (en) | Ultrasonic couplant and preparation method thereof | |
| CN103768308A (en) | Medicament composition for treating upper respiratory infections and preparation method thereof | |
| CN105169017A (en) | Traditional Chinese medicine for treating kidney stone and preparation method of traditional Chinese medicine | |
| CN101301389B (en) | Chinese medicinal composition for treating mammilla and lacteal cistern neoplasm disease of milk cattle and preparation and use thereof | |
| CN102139051B (en) | Application of soft capsule capable of clearing heat and eliminating toxin in preparation of medicament for treating viral pneumonia | |
| CN104606385A (en) | Traditional Chinese medicine preparation for treating paronychia | |
| CN104257763B (en) | A kind of saline cistanche water extract, preparation method and its usage | |
| CN102552796A (en) | Chinese medicinal composition for treating chronic gastric ulcer | |
| CN103071142B (en) | Quick-acting external patch for tracheitis | |
| CN105770074A (en) | Traditional Chinese medicine composition for treating wind-heat common cold and preparation method thereof | |
| CN105055875A (en) | Traditional Chinese medicine used for treating cold-dampness heat-type endometritis, and preparation method thereof | |
| CN101683452A (en) | Animal Chinese medicine oral liquid for preventing and treating infectious bursal disease of fowl and preparation method thereof | |
| CN101301422B (en) | Chinese medicinal composition for treating mastitis of milk cattle and preparation and application thereof | |
| CN104758530A (en) | Traditional Chinese medicine composition for treating deficiency of both qi and blood type irregular menstruation | |
| CN103721058A (en) | Traditional Chinese medicine preparation for preventing influenza viruses | |
| CN103463402B (en) | Traditional Chinese medicine composition for infantile asthma and preparation method thereof | |
| CN103110737B (en) | Traditional Chinese medicine composition for treating gynecologic inflammation and preparation method thereof | |
| CN105878664A (en) | Chinese and western medicine combined prescription for treating dental ulcer | |
| CN105250774A (en) | Traditional Chinese medicine composition for treating chronic influenza | |
| CN105663657A (en) | Decoction medicine capable of effectively treating fire excess from yin deficiency and preparation method thereof | |
| CN105213644A (en) | A kind of Chinese medicine preparation for the treatment of acute mastitis and preparation method thereof | |
| CN105031364A (en) | Preparation for preventing and treating toothache due to wind-fire evil and preparation method of preparation | |
| CN104984231A (en) | Traditional Chinese medicine for treating malaria | |
| CN103110924A (en) | Medicine for treating hemorrhoids |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: BEIAN FEILONG ANIMAL MEDICINE FACTORY Free format text: FORMER OWNER: ZHAO SHOUCAI Effective date: 20120301 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20120301 Address after: 164000 Heilongjiang province Bei'an City Qinghua high tech park Bei'an Feilong animal pharmaceutical factory Patentee after: BEI'AN FEILONG ANIMAL PHARMACEUTICAL FACTORY Address before: 164000 Heilongjiang province Bei'an City Qinghua high tech park Bei'an Feilong animal pharmaceutical factory Patentee before: Zhao Shoucai |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20101013 Termination date: 20180707 |