CN101297873B - Chinese and western compound medicament composition for preventing and controlling aquatic livestock hepatobiliary syndrome - Google Patents
Chinese and western compound medicament composition for preventing and controlling aquatic livestock hepatobiliary syndrome Download PDFInfo
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- CN101297873B CN101297873B CN2007101504602A CN200710150460A CN101297873B CN 101297873 B CN101297873 B CN 101297873B CN 2007101504602 A CN2007101504602 A CN 2007101504602A CN 200710150460 A CN200710150460 A CN 200710150460A CN 101297873 B CN101297873 B CN 101297873B
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Abstract
The invention relates to the field of aquaculture industry, in particular to a compound Chinese-western pharmaceutical composition for prevention and treatment for liver and gall bladder syndrome of aquatic animals. The compound Chinese-western pharmaceutical composition is characterized in that: the composition according to parts by weight is as follows: 200 to 400 parts of Chinese thorowax root, 300 to 400 parts of indigowoad leaf, 100 to 200 parts of rhubarb, 20 to 70 parts of motherwort herb, 10 to 30 parts of glucurolactone and 100 to 200 parts of starch. The compound Chinese-western pharmaceutical composition has great effects on prevention and treatment for the liver and gall bladder syndrome of the aquatic animals and no medicine residue.
Description
Technical field
The present invention relates to field of aquaculture industry, particularly a kind of Chinese and Western compound medicament composition of preventing and treating the aquatic animal liver and gallbladder syndrome.
Background technology
Along with the fast development of China's culture fishery, the achievement that China's aquaculture has been obtained huge, continuous 19 years aquatic products total amounts ranked first in the world to 2006.Simultaneously, the appearance of high density, intensive culture pattern and development cause breeding environment to worsen and the breaking out with popular of thing followed fish diseases, thereby to have occurred be the new fish disease of principal character with the hepatobiliary disease, be liver and gall syndrome of fish, culture to Aquatic product and bring bigger negative effect.The reason that causes liver and gallbladder syndrome mainly contains three major types: the one, and cultivation density is excessive, water body environment worsens.When the ammonia nitrogen concentration in the water body was too high, the metabolite of ammonia was difficult to normally discharge and accumulate among blood in the fish body, caused that the Fish metabolic imbalance causes liver and gall diseases.The 2nd, abuse medicine.As low dosage, in feedstuff, add furazolidone, chloromycetin, sulfonamides etc. for a long time, or use side effect big, residual high fish medicine such as medicines such as metrifonate, copper sulfate, caused hepatic injury.The 3rd, feedstuff becomes sour rotten; contain noxious substance and vitamin deficiency in the unbalance and feedstuff of nutritional labeling; too high as protein content; carbohydrate content higher or life-time service animal fat and height satisfied fatty acid etc.; cause fodder energy albumen than too high; high protein feed easily brings out the liver fat accumulation; destroy liver function; disturb Fish normal physiological biochemical metabolism; carbohydrate content is too high; can cause the Fish carbohydrate metabolism disturbance; cause the interior fat accumulation, hinder normal function, its major lesions position is a liver; a large amount of glycogen accumulation and fatty infiltration; cause hepatomegaly, color and luster is thin out, the appearance tarnish; serious fatty liver also can cause liver pathological changes, makes liver lose normal function.At present to the medicine of the control of this type of aquatic animal liver and gallbladder syndrome, aspect drug effect, the drug residue also existence make us not satisfied place.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, a kind of Chinese and Western compound medicament composition of preventing and treating the aquatic animal liver and gallbladder syndrome is provided, at the aquatic animal liver and gallbladder syndrome, prevention effect of the present invention is fine, drug residue free.
For achieving the above object, the technical solution adopted in the present invention is as follows:
A kind of Chinese and Western compound medicament composition of preventing and treating the aquatic animal liver and gallbladder syndrome is characterized in that consisting of by weight:
Radix Bupleuri 200-400 part, Folium Isatidis 300-400 part, Radix Et Rhizoma Rhei 100-200 part, Herba Leonuri 20-70 part, glucurolactone 10-30 part, starch 100-200 part.
The preparation method of the Chinese and Western compound medicament composition of this control aquatic animal liver and gallbladder syndrome, take by weighing the component of above-mentioned composition by weight, adopt the cell wall-broken micro powder production technology, to wait to pulverize each component of Chinese crude drug and place totally-enclosed powder body equipment, under-50 ℃～30 ℃ temperature, adopt mechanical presses, bump that Chinese crude drug is pulverized, mix with glucurolactone and starch by proportioning then, stir, promptly make a kind of Chinese and Western compound medicament composition of preventing and treating the aquatic animal liver and gallbladder syndrome.
The characteristic of component of the present invention:
(1), Radix Bupleuri: perennial herb, main root is cylindrical, matter is hard, root is directly given birth to.The Radix Bupleuri root contains volatile oil, bupleurumol, oleic acid, linolenic acid, Palmic acid, hard ester acid, carnaubic acid, glucose and Saponin etc., saikoside is arranged, saikoside unit, longispinogenin in the Saponin.Property of medicine hardship is slightly cold.Have antiviral, kill protozoon effect, anti-hepar damnification effect.
(2), Folium Isatidis: the roadside Folium Isatidis contains flavonoid.The polygonum tinctorium ait. herb contains indigo glycoside, flavochrome and tannin.Contain the anthraquinone class in the root.The Isatis indigotica Fort. leaf contains tryptophan, isatan B, glucose Caulis et Folium Brassicae campestris element, new glucose Caulis et Folium Brassicae campestris element, glucose Caulis et Folium Brassicae campestris element-1-sulfonate.Contain indigo again.The grass Folium Isatidis contains the indigo glycoside.Folium acanthaceous indigo contains the indigo glycoside.The hydrolysis of indigo glycoside generates indoxyl.Indoxyl promptly generates indigo through oxidation.Property of medicine hardship, cold.Has antibiotic, antivirus action.
(3), Radix Et Rhizoma Rhei: anthraquinone analog compound, comprise in conjunction with or chrysophanol, emodin, aloe-emodin, chrysophanic acid and the physcione of free state.Radix Et Rhizoma Rhei also contains rheotannic acid and related substances thereof, as gallic acid, cachou extract and tetrarin.These tannic acids and related substances thereof have anti-diarrhea effect, and be just opposite with the discharge function of the glycoside of anthraquinone derivative.In addition, Radix Et Rhizoma Rhei also contains fatty acid, as caproic acid, Palmic acid, stearic acid, oleic acid, linoleic acid plus linolenic acid.
(4), Herba Leonuri: the Herba Leonuri herb contains leonurine (leonurine) about 0.05% and (spends the initial stage to contain trace, spend increase gradually mid-term), stachydrine (stachydrine), rutin (rutin), Fumaric acid (fumaric acid fumaric acid), leonurine first and leonurine second.The Herba Leonuri Sibirici herb contains alkaloid 0.05%.The content of leonurine is with changing the period of blooming in the herb, the initial stage content of spending is very little, it is 0.01-0.03% that 7-8 spends mid-term content the middle of the month, reach as high as 0.04%, and contain stachydrine, leonuridine alkali (leonuridine), 4-guanidine radicals butanols-1 (4-guanidino-1-butanol), 4-guanidine radicals butanoic acid (4-guanidino-butyric acid), arginine (arginine), micro-rutin, stachyose (stachyose), plant sterol, resin, fatty oil, lauric acid (lauric acid), linoleic acid (linoleic acid), β-linoleic acid (β-linoleic acid) and oleic acid (oleic acid).Bitter in the mouth, suffering, cold nature.Promoting blood flow to regulate menstruation is arranged, promoting tissue regeneration by removing blood stasis, the function of inducing diuresis to remove edema.
(5) glucurolactone: this product is white crystals or crystalline powder; Odorless, mildly bitter flavor; It is dark to meet photochromic gradual change; After water-soluble, a part of lactone becomes glucuronic acid, reaches poised state, shows acid reaction.Easily molten in water, molten in the methanol part omitted, little molten in ethanol.Glucuronic acid lactone can form glucuronic acid in vivo, excrete after being combined into nontoxic glucuronide conjugate with many inside and outsides poisonous substance (in the liver, enterogenous endotoxin, chemicals, poisonous substance) and metabolite thereof, thus the effect of performance hepatoprotective and detoxication and toxicant eliminating function.Be used for the protection and the reparation of aquatic animal disease liver function, and demonstrated good effect.
(6) starch: mainly play binding agent.
The source of each component among the present invention: each component is pharmaceutical grade.
The beneficial effect that the present invention had:
The present invention is with above-mentioned each component organic assembling, complement each other, can bring into play the function of each component to greatest extent, medicinal herb components wherein adopts the cell wall-broken micro powder production technology, increases the dissolution of medicine, improve the bioavailability of active ingredient, cell wall breaking rate height, the Western medicine glucurolactone of arranging in pairs or groups simultaneously, Chinese and Western component function synergism, the aquatic animal liver and gallbladder syndrome is had good preventive and therapeutic effect, and drug residue free.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1:
Take by weighing 200 parts of Radix Bupleuri by weight, 400 parts of Folium Isatidiss, 200 parts of Radix Et Rhizoma Rhei, 20 parts of Herba Leonuris, 10 parts of glucurolactones, 200 parts of starch adopt the cell wall-broken micro powder production technology, will wait to pulverize each component of Chinese crude drug and place totally-enclosed powder body equipment, under-50 ℃～30 ℃ temperature, adopt mechanical presses, bump that Chinese crude drug is pulverized, mix with glucurolactone and starch then, stir, promptly make a kind of Chinese and Western compound medicament composition of preventing and treating the aquatic animal liver and gallbladder syndrome.
Embodiment 2:
Take by weighing 400 parts of Radix Bupleuri by weight, 300 parts of Folium Isatidiss, 100 parts of Radix Et Rhizoma Rhei, 70 parts of Herba Leonuris, 10 parts of glucurolactones, 100 parts of starch adopt the cell wall-broken micro powder production technology, will wait to pulverize each component of Chinese crude drug and place totally-enclosed powder body equipment, under-50 ℃～30 ℃ temperature, adopt mechanical presses, bump that Chinese crude drug is pulverized, mix with glucurolactone and starch then, stir, promptly make a kind of Chinese and Western compound medicament composition of preventing and treating the aquatic animal liver and gallbladder syndrome.
Embodiment 3:
Take by weighing 400 parts of Radix Bupleuri by weight, 400 parts of Folium Isatidiss, 100 parts of Radix Et Rhizoma Rhei, 20 parts of Herba Leonuris, 10 parts of glucurolactones, 100 parts of starch adopt the cell wall-broken micro powder production technology, will wait to pulverize each component of Chinese crude drug and place totally-enclosed powder body equipment, under-50 ℃～30 ℃ temperature, adopt mechanical presses, bump that Chinese crude drug is pulverized, mix with glucurolactone and starch then, stir, promptly make a kind of Chinese and Western compound medicament composition of preventing and treating the aquatic animal liver and gallbladder syndrome.
Embodiment 4:
Take by weighing 400 parts of Radix Bupleuri by weight, 300 parts of Folium Isatidiss, 100 parts of Radix Et Rhizoma Rhei, 20 parts of Herba Leonuris, 10 parts of glucurolactones, 200 parts of starch adopt the cell wall-broken micro powder production technology, will wait to pulverize each component of Chinese crude drug and place totally-enclosed powder body equipment, under-50 ℃～30 ℃ temperature, adopt mechanical presses, bump that Chinese crude drug is pulverized, mix with glucurolactone and starch then, stir, promptly make a kind of Chinese and Western compound medicament composition of preventing and treating the aquatic animal liver and gallbladder syndrome.
Embodiment 5:
Take by weighing 200 parts of Radix Bupleuri by weight, 400 parts of Folium Isatidiss, 100 parts of Radix Et Rhizoma Rhei, 70 parts of Herba Leonuris, 10 parts of glucurolactones, 200 parts of starch adopt the cell wall-broken micro powder production technology, will wait to pulverize each component of Chinese crude drug and place totally-enclosed powder body equipment, under-50 ℃～30 ℃ temperature, adopt mechanical presses, bump that Chinese crude drug is pulverized, mix with glucurolactone and starch then, stir, promptly make a kind of Chinese and Western compound medicament composition of preventing and treating the aquatic animal liver and gallbladder syndrome.
Embodiment 6:
Take by weighing 400 parts of Radix Bupleuri by weight, 300 parts of Folium Isatidiss, 100 parts of Radix Et Rhizoma Rhei, 70 parts of Herba Leonuris, 10 parts of glucurolactones, 100 parts of starch adopt the cell wall-broken micro powder production technology, will wait to pulverize each component of Chinese crude drug and place totally-enclosed powder body equipment, under-50 ℃～30 ℃ temperature, adopt mechanical presses, bump that Chinese crude drug is pulverized, mix with glucurolactone and starch then, stir, promptly make a kind of Chinese and Western compound medicament composition of preventing and treating the aquatic animal liver and gallbladder syndrome.
Application experiment:
Jiangsu Province connects and to go to main foster Cyprinus carpio district, port, to 7, during August, liver and gallbladder syndrome takes place easily, sick fish their early stage, and the fish body does not generally have tangible symptom, inappetence only, it is unable to move about, and mortality rate is not high.Along with PD, fish body colour blackout, color and luster is dark and gloomy, the fish body has the edema sense, and it is irregular to move about, disequilibrium, quiet lying in the water reacts dull, dyspnea, the obvious enlargement of liver, big more than 1 times under the comparable normal condition, Hepatic flavescence gradually turns white, or it is alternate to be the yellow red and white of speckle shape, form significantly " flower liver ", make liver part or the major part that have become " green liver "; The liver that has touches frangible, and the obvious enlargement 1-2 of gallbladder is (causing bile to overflow or rupture of gallbladder) sometimes doubly, and bile darkens green or blackish green.The most typical feature of primary disease is liver and gall enlargement and variable color.During diagnosis, the inspection fish body surface and the gill, eye etc. are located pathological changes earlier, cut fish belly then open, conscientiously check liver and gall pathological changes situation,, can tentatively be defined as liver and gall class disease if liver, gallbladder enlargement and variable color are obvious, select for use medicine to mix clothes this product 1000g with the feedstuff of every 100kg, through after 5-7 days the treatment, the state of an illness has obtained obvious control, and it is normal that the fish body recovers substantially.
Claims (1)
1. Chinese and Western compound medicament composition of preventing and treating the aquatic animal liver and gallbladder syndrome is characterized in that consisting of by weight:
Radix Bupleuri 200-400 part, Folium Isatidis 300-400 part, Radix Et Rhizoma Rhei 100-200 part, Herba Leonuri 20-70 part, glucurolactone 10-30 part, starch 100-200 part.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007101504602A CN101297873B (en) | 2007-11-27 | 2007-11-27 | Chinese and western compound medicament composition for preventing and controlling aquatic livestock hepatobiliary syndrome |
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| CN2007101504602A CN101297873B (en) | 2007-11-27 | 2007-11-27 | Chinese and western compound medicament composition for preventing and controlling aquatic livestock hepatobiliary syndrome |
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| CN101297873A CN101297873A (en) | 2008-11-05 |
| CN101297873B true CN101297873B (en) | 2010-11-10 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102246911A (en) * | 2011-04-20 | 2011-11-23 | 广州市新科农饲料科技有限公司 | Application of glucuronolactone as additive in fish feed |
| CN103127263A (en) * | 2013-02-28 | 2013-06-05 | 张丽香 | Drug for treating oyster perkinsus disease |
| CN104398599A (en) * | 2014-12-10 | 2015-03-11 | 安徽省旌德县国友龟鳖良种繁育场 | Medicament for treating hepatobiliary syndrome of soft-shelled turtles |
| CN107048090B (en) * | 2017-05-16 | 2019-07-26 | 广东海因特生物技术集团有限公司 | A kind of premix and its preparation method and application for repairing the white liver pathological changes of grass carp |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1415365A (en) * | 2002-10-25 | 2003-05-07 | 广西南宁悦丰天然生物工程有限公司 | Chinese medical preparation for preventing and curing blaze of shrimps corpus hemorrhagicum, gill rot and pond syndrome |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1415365A (en) * | 2002-10-25 | 2003-05-07 | 广西南宁悦丰天然生物工程有限公司 | Chinese medical preparation for preventing and curing blaze of shrimps corpus hemorrhagicum, gill rot and pond syndrome |
Non-Patent Citations (1)
| Title |
|---|
| 胡宝林.鱼类肝胆综合症的防治.渔业致富指南.2006,(4),46，47. * |
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Effective date of registration: 20120924 Address after: 300384 Tianjin Huayuan Industrial Zone Haitai two Road No. 2 Patentee after: Tianjin Shengji Group Co., Ltd. Address before: 301609. 2, Tianyu Science Park, Jinghai, Tianjin Patentee before: Tianjin Shengji Group Co., Ltd. |
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