CN101297761A - Thermotherapy nondestructive temperature measuring equipment based on type-B ultrasonic image - Google Patents
Thermotherapy nondestructive temperature measuring equipment based on type-B ultrasonic image Download PDFInfo
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- CN101297761A CN101297761A CNA2008100391885A CN200810039188A CN101297761A CN 101297761 A CN101297761 A CN 101297761A CN A2008100391885 A CNA2008100391885 A CN A2008100391885A CN 200810039188 A CN200810039188 A CN 200810039188A CN 101297761 A CN101297761 A CN 101297761A
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Abstract
This invention relates to a heat treatment non-destructive temperature measuring equipment which is based on B-ultrasonic image and belongs to the technical field of biomedical engineering, comprising a computer controls relay switch and a power amplifier module, wherein, the computer controls a collecting module of B-ultrasonic image and a combination probe module, the computer controls the setting of the relay switch and the power amplifier module and adjusts the output power of a focused transducer probe in the combination probe module, the duty factor and launching time of the impulse wave so as to control the launching dose; the computer controls the collecting module of B-ultrasonic image, confirms the collection of B-ultrasonic image by an image grabbing card, sets a frequency and times for the image collection in the computer and feedbacks the collecting image to the computer in real time; the combination probe module leads the B-ultrasonic probe to be combined with the focused transducer probe which leads the B-ultrasonic image to show the information of focused section clearly and finally leads the B-ultrasonic image to be collected by the computer. The heat treatment non-destructive temperature measuring equipment detects the temperature variety by adopting ultra audible sound with the advantages of smaller the used equipment, simple operation and low cost.
Description
Technical field
The present invention relates to a kind of device of medical apparatus and instruments field of engineering technology, particularly a kind of thermotherapy nondestructive temperature measuring equipment based on the B ultrasonic image.
Background technology
High intensity focused ultrasound (HIFU) thermotherapy adjuvant chemotherapy, radiotherapy can effectively suppress the growth of tumor cell, and therapeutic effect is remarkable.In the thermotherapy process, the control of HIFU emission dosage is most important.Accurate dose control not only helps to improve therapeutic effect, and can avoid temperature too high and tissue that cause is burnt, thereby alleviates patient's misery, reduces operation risk.Yet up to the present, still lack the effectively method of control HIFU emission dosage clinically.
At present, the method of HIFU thermotherapy emission dosage control mainly is clinically, the clinician is according to HIFU zoopery result and clinical experience, by setting and adjust the output of HIFU power amplifier, the dutycycle of impulse wave, and launch time control emission dosage, exchange with the uninterrupted of patient by the doctor simultaneously, the inquiry patient impression adjust emission dosage.If patient's feels pain is unbearably, other untoward reaction is perhaps arranged, the doctor then reduces to launch dosage, even temporarily stops treatment.There is following several problem in this method: 1) because the individual patient diversity does not have the unified emission dosage that is suitable for.Often run into such problem clinically, same emission dosage, for patient's first, curative effect is good; But, then do not reach therapeutic effect for patient's second; For patient the third, then it might be burnt.2) for the patient of local anesthesia or general anesthesia, because patient and doctor's communication is blocked, clinically the case that patient burns can take place.
Find through literature search prior art, K.Hynynen etc. are at Int J Hyperthermia, 20 (7), pp.725-737, deliver " MRI guided and monitored focused ultrasoundthermal ablation methods:a review of progress; " on 2004, middle proposition nuclear magnetic resonance, NMR (MRI) is the potential method of the auxiliary HIFU of realization thermotherapy dosage control, but still is in the experimental stage at present.Nuclear magnetic resonance, NMR (MRI) has temperature measurement accuracy height characteristics such as (precision can reach 0.5 degree centigrade), but MRI has following limitation: 1) MRI apparatus expensive, limited popularizing and promoting on the HIFU thermometric; 2) the MRI image taking speed is slow and Flame Image Process is complicated, difficultly realizes real-time monitoring temperature; (0.5s ~ 5s) rise to more than 75 degrees centigrade, giving in real time, monitoring brings new challenge instantaneous for HIFU thermotherapy particularly, focus area temperature.3) MRI has the requirement of comparison harshness for the clinical treatment condition, can not will have the material of magnetic, is placed into the intracavity of MRI, and this just proposes new requirement to probe and other therapeutic equipment of HIFU.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, a kind of thermotherapy nondestructive temperature measuring equipment based on the B ultrasonic image is provided, it is adopted ultrasonicly come detected temperatures to change, not only equipment therefor is less, operates also simply, and cost is low.
The present invention is achieved by the following technical solutions, the present invention includes: be closely connected mutually between computer control relay switch and power amplifier module, computer control B ultrasonic image capture module, coupling probe module, the module and form a whole set of device.Wherein:
Described computer control relay switch and power amplifier module set and adjust the output of focused transducer probe in the coupling probe module by serial communication, the dutycycle of impulse wave, and control emission dosage launch time; Described computer control B ultrasonic image capture module is determined the collection of image pick-up card to the B ultrasonic image by computer, and the frequency of images acquired is set in computer, and number of times is with real-time the feeding back in the computer of image of gathering; Described coupling probe module mechanically makes Ultrasonic-B probe and focused transducer probe combine preferably, makes the B ultrasonic image can reflect burnt territory partial information preferably, finally allows computer acquisition arrive the B ultrasonic image of most worthy.
Described computer control relay switch and power amplifier module, starting module for whole system, carry serial ports by computer, USB mouth and control relay circuit, power amplifier is formed, use a computer and carry in the 9 pin serial ports No. 4, No. 5 pins and USB mouth are the relay switching circuit power supply as power supply, utilize the duty of serial communication control relay simultaneously, therefore parameter is set in computer, can control the power supply of power amplifier to focused transducer in the coupling probe, finally the function that can realize is: the output of setting and adjust the focused transducer probe, the dutycycle of impulse wave, and control emission dosage launch time.
Described computer control B ultrasonic image capture module is made up of computer, image pick-up card and B ultrasonic, by video output S-video end image pick-up card is connected with B ultrasonic, and by the computer installation image acquisition parameter, as number of times, frequency etc.Because the focused transducer in the coupling probe module is when clinical treatment, its therapeutic frequency produces the frequency spectrum than broad, and the diagnosis frequency of Ultrasonic-B probe is had very big interference, and can not gather the B ultrasonic image this moment.Therefore, when the computer installation image acquisition parameter, coordinate, stagger acquisition time and strike time, make whole system optimization with computer control relay switch and power amplifier module.
Described coupling probe module is made up of Ultrasonic-B probe and focused transducer, and Ultrasonic-B probe is embedded in the focused transducer.Its core is the compound mode of two probes, because the planar image that Ultrasonic-B probe is surveyed, it is a spheroid that focused transducer is treated formed burnt territory.Therefore to make the cross section and the B ultrasonic planes overlapping of this ellipsoid.
The present invention adopts the mode of computer control relay switch to set and adjust the output of focused transducer probe, the dutycycle of impulse wave, and control emission dosage launch time, and the efficient height, more directly perceived, than prior art further improvement has been arranged.Relay switching circuit wherein, element is simple, and quantity is little, can be integrated, realize easily, and easy communication, for the present invention is making bigger contribution aspect the efficient.
The advantage of the relative conventional art of the present invention is: 1, be core with the computer, all operations all has computer to finish, and simple to operate, has practical significance.2, based on the noninvasive temperature estimation of B ultrasonic, have greater advantage than the noninvasive temperature estimation based on MRI: cost is low, is easy to realize, and is not high to environmental requirement.3, adopt computer control mode, can set and adjust the output of focused transducer probe arbitrarily, the dutycycle of impulse wave, and control emission dosage launch time, and the efficient height, more directly perceived.On clinical treatment, has certain meaning.4, the control image acquisition that uses a computer is coordinated whole system more, avoids the conflict between each module.5, the circuit part element is fairly simple, be easy to realize, and easy communication, and stability is high.6, coupling probe is reasonable in design, has guaranteed the image accuracy.
Description of drawings
Fig. 1 is apparatus of the present invention structured flowcharts
Fig. 2 is relay switching circuit figure of the present invention
Fig. 3 is coupling probe structural profile a of the present invention and cross section b structural representation
Wherein: 1. focused transducer is popped one's head in, the super probe of 2.B
The specific embodiment
Below in conjunction with accompanying drawing embodiments of the invention are elaborated: present embodiment is being to implement under the prerequisite with the technical solution of the present invention, provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
As shown in Figure 1, present embodiment comprises: be closely connected mutually between computer control relay switch and power amplifier module, computer control B ultrasonic image capture module, coupling probe module, the module and form a whole set of device.Wherein: described computer control relay switch and power amplifier module set and adjust the output of focused transducer probe in the coupling probe module by serial communication, the dutycycle of impulse wave, and control emission dosage launch time; Described computer control B ultrasonic image capture module is determined the collection of image pick-up card to the B ultrasonic image by computer, and the frequency of images acquired is set in computer, and number of times transmits back the image information of gathering in the computer in real time; Described coupling probe module mechanically makes Ultrasonic-B probe and focused transducer probe combine preferably, and the B ultrasonic image can reflect burnt territory partial information preferably, and final purpose is to make computer acquisition arrive the B ultrasonic image of most worthy.
Computer shown in Figure 1 is that the core of whole system is formed, by its derived respectively computer control relay switch and power amplifier module and computer control B ultrasonic image capture module, described computer control relay switch and power amplifier module only need use a computer and carry in the 9 pin serial ports No. 4, No. 5 pins and USB mouth are the relay switching circuit power supply as power supply, utilize the duty of serial communication control relay simultaneously, parameter is set in computer, can control the power supply of power amplifier to focused transducer in the coupling probe, the final function that realizes is: the output of setting and adjust the focused transducer probe, the dutycycle of impulse wave, and control emission dosage launch time.
Described computer control B ultrasonic image capture module only needs image pick-up card is connected respectively the PCI slot and the digital B ultrasonic S-video outfan of computer, by the concrete parameter of computer installation image acquisition, and as frequency, number of times etc.Because focused transducer is when clinical treatment, its therapeutic frequency produces the frequency spectrum than broad, and the diagnosis frequency of Ultrasonic-B probe is had very big interference, and can not gather the B ultrasonic image this moment.Therefore, when the computer installation image acquisition parameter, coordinate, stagger acquisition time and strike time, make whole system optimization with computer control relay switch and power amplifier module.
As shown in Figure 2, the relay control switch circuit is for realizing the Key Circuit of therapeutic dose control, and major function is the folding of control power amplifier, the final control that realizes the focused transducer duty.Its concrete connected mode is: No. 4 pins of Vo termination serial ports; the resistance that at first to connect a size afterwards be 51K; it mainly acts on is dividing potential drop; as shown in the figure; after divider resistance, be connected to the base stage of 9012 audions of on-off action; its grounded emitter; the resistance of an emitter stage and base stage two ends 4.7K in parallel; its objective is current limliting; the collector connection relay negative input end of audion, relay positive input termination USB feeder ear is simultaneously at relay input light emitting diode in parallel; play indicative function, mainly play the current-limiting protection effect and the size of connecting with light emitting diode is the resistance of 4.7K.Wherein core content is: Vo10V is by No. 4 and No. 5 pin power supplies of serial ports, and Vc5V is by USB confession electricity, and 9012 audions have played on-off action, externally confirm the relay duty by light emitting diode.When serial ports provides high level, com-state promptly is set when opening in computer, the relay output end closure, LED light lamp is bright, and the focused transducer of this moment is in running order; When serial ports provided low level, relay output end was opened, and LED light lamp is gone out, and focused transducer is not worked.
As shown in Figure 3, the mechanical bond structure of coupling probe two component parts has been described, be divided into profile a and sectional view b, focused transducer probe 1 is a spill, lower hollow, Ultrasonic-B probe 2 is embedded in the focused transducer, becomes a plane with the burnt territory of strike part, to reach the purpose of gathering optimal B ultrasonic image.
Present embodiment is by gathering the B ultrasonic image in real time, and computer analysis is handled and extract tissue temperature information from the B ultrasonic image, and the generation energy of feedback control ultrasonic transducer.Control to the ultrasonic transducer transmitting power recently realizes by the control duty.This system applies is in clinical cancer therapy, and all operations all is core with the computer, and main purpose is to calculate control target area temperature value in real time, has merged the function of computer control therapeutic dose simultaneously.When clinical treatment, various relevant parameters are set in computer, and then gather and hit the real time imaging of target area at interval, carry out Flame Image Process, result of calculation is fed back in real time.
Advantages such as noninvasive temperature estimation is little to human body harm with it, and ultrasound wave is very responsive to tissue characteristics difference, and anti-electromagnetic interference is strong, and extremely people pay close attention to.And change with the ultrasonic method detected temperatures, not only equipment therefor is less, operates also simple.The noninvasive temperature estimation technology is utilized ultrasonic scanning thermotherapy biological tissue, based on characteristics such as velocity of ultrasonic sound model, nonlinear parameter, echo time shift characteristic, echo frequency shift property and scattared energies, ultrasonic signal is analyzed, extract tissue temperature information effectively, have comprehensive performance than additive method; The ultrasonic MRI technology of comparing, in real-time, generalization, the feasibility aspect, improved the prior art level greatly, make in the therapeutic process temperature in real time feedback become possibility, price is compared with MRI has very large advantage, and also much lower than MRI for environment requirement, real-time monitoring temperature provides possibility during for the HIFU clinical treatment.
Claims (4)
1, a kind of thermotherapy nondestructive temperature measuring equipment based on the B ultrasonic image, it is characterized in that, comprise: computer control relay switch and power amplifier module, computer control B ultrasonic image capture module, coupling probe module, wherein: described computer control relay switch and power amplifier module set and adjust the output of focused transducer probe in the coupling probe module by serial communication, the dutycycle of impulse wave, and control emission dosage launch time; Described computer control B ultrasonic image capture module is determined the collection of image pick-up card to the B ultrasonic image by computer, and the frequency of images acquired is set in computer, and number of times is with real-time the feeding back in the computer of image of gathering; Described coupling probe module mechanically makes Ultrasonic-B probe and focused transducer probe combine, and makes the B ultrasonic image reflect burnt territory partial information, finally allows computer acquisition arrive the B ultrasonic image.
2, thermotherapy nondestructive temperature measuring equipment based on the B ultrasonic image according to claim 1, it is characterized in that, described computer control relay switch and power amplifier module, starting module for whole system, carry serial ports by computer, USB mouth and control relay circuit, power amplifier is formed, use a computer and carry in the 9 pin serial ports No. 4, No. 5 pins and USB mouth are the relay switching circuit power supply as power supply, utilize the duty of serial communication control relay simultaneously, by the power supply of parameter control power amplifier to focused transducer in the coupling probe, the final output of realizing setting and adjusting the focused transducer probe are set in computer, control the dutycycle of impulse wave and launch time emission dosage.
3, the thermotherapy nondestructive temperature measuring equipment based on the B ultrasonic image according to claim 1, it is characterized in that, described computer control B ultrasonic image capture module is made up of computer, image pick-up card and B ultrasonic, by video output S-video end image pick-up card is connected with B ultrasonic, by the computer installation image acquisition parameter, when the computer installation image acquisition parameter, coordinate with computer control relay switch and power amplifier module, stagger acquisition time and strike time.
4, the thermotherapy nondestructive temperature measuring equipment based on the B ultrasonic image according to claim 1, it is characterized in that, described coupling probe module is made up of Ultrasonic-B probe and focused transducer, Ultrasonic-B probe is embedded in the focused transducer, the planar image that Ultrasonic-B probe is surveyed, it is a spheroid that focused transducer is treated formed burnt territory, must make the cross section and the B ultrasonic planes overlapping of this ellipsoid.
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| CNB2008100391885A CN100563580C (en) | 2008-06-19 | 2008-06-19 | Thermotherapy nondestructive temperature measuring equipment based on the B ultrasonic image |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526899A (en) * | 2010-12-29 | 2012-07-04 | 重庆微海软件开发有限公司 | Focused ultrasonic therapy system and monitoring method thereof |
| CN104736200A (en) * | 2012-11-05 | 2015-06-24 | 皇家飞利浦有限公司 | Medical apparatus for determining a maximum energy map |
| CN105072983A (en) * | 2013-02-22 | 2015-11-18 | 皇家飞利浦有限公司 | Hyperthermia for diagnostic imaging |
| CN107497062A (en) * | 2017-08-31 | 2017-12-22 | 中国科学院苏州生物医学工程技术研究所 | Focusing ultrasound fat melting system based on noninvasive temperature monitoring |
| CN109999376A (en) * | 2019-03-19 | 2019-07-12 | 深圳市声科生物医学研究院 | A kind of HIFU apparatus control system and its noninvasive temperature estimation method |
-
2008
- 2008-06-19 CN CNB2008100391885A patent/CN100563580C/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526899A (en) * | 2010-12-29 | 2012-07-04 | 重庆微海软件开发有限公司 | Focused ultrasonic therapy system and monitoring method thereof |
| CN102526899B (en) * | 2010-12-29 | 2015-04-22 | 重庆微海软件开发有限公司 | Focused ultrasonic therapy system and monitoring method thereof |
| CN104736200A (en) * | 2012-11-05 | 2015-06-24 | 皇家飞利浦有限公司 | Medical apparatus for determining a maximum energy map |
| CN104736200B (en) * | 2012-11-05 | 2018-09-21 | 皇家飞利浦有限公司 | Medical apparatus for determining ceiling capacity figure |
| CN105072983A (en) * | 2013-02-22 | 2015-11-18 | 皇家飞利浦有限公司 | Hyperthermia for diagnostic imaging |
| CN105072983B (en) * | 2013-02-22 | 2018-05-15 | 皇家飞利浦有限公司 | Thermotherapy for diagnosing image |
| CN107497062A (en) * | 2017-08-31 | 2017-12-22 | 中国科学院苏州生物医学工程技术研究所 | Focusing ultrasound fat melting system based on noninvasive temperature monitoring |
| CN107497062B (en) * | 2017-08-31 | 2024-01-23 | 中国科学院苏州生物医学工程技术研究所 | Focusing ultrasonic fat dissolving system based on noninvasive temperature monitoring |
| CN109999376A (en) * | 2019-03-19 | 2019-07-12 | 深圳市声科生物医学研究院 | A kind of HIFU apparatus control system and its noninvasive temperature estimation method |
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| CN100563580C (en) | 2009-12-02 |
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