CN101288841A - 一种头孢菌素c提取专用大孔吸附树脂及其制备方法 - Google Patents
一种头孢菌素c提取专用大孔吸附树脂及其制备方法 Download PDFInfo
- Publication number
- CN101288841A CN101288841A CNA2008100168172A CN200810016817A CN101288841A CN 101288841 A CN101288841 A CN 101288841A CN A2008100168172 A CNA2008100168172 A CN A2008100168172A CN 200810016817 A CN200810016817 A CN 200810016817A CN 101288841 A CN101288841 A CN 101288841A
- Authority
- CN
- China
- Prior art keywords
- cephalosporin
- monomer
- adsorption resin
- preparation
- macroporous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
- B01J20/267—Cross-linked polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28057—Surface area, e.g. B.E.T specific surface area
- B01J20/28066—Surface area, e.g. B.E.T specific surface area being more than 1000 m2/g
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28069—Pore volume, e.g. total pore volume, mesopore volume, micropore volume
- B01J20/28076—Pore volume, e.g. total pore volume, mesopore volume, micropore volume being more than 1.0 ml/g
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28078—Pore diameter
- B01J20/28085—Pore diameter being more than 50 nm, i.e. macropores
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/305—Addition of material, later completely removed, e.g. as result of heat treatment, leaching or washing, e.g. for forming pores
- B01J20/3064—Addition of pore forming agents, e.g. pore inducing or porogenic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Description
树脂样品 | 吸附量 | 解析液产出量 | 解析液产率 | 洗脱难易程度 | CPC回收率 | 解析液CPC纯度 | 解析液DCPC浓度 | 解析液DOCPC浓度 | 吸光比值 | 溶媒相膨胀率 | 综合评价 |
1# | 居中 | 最高 | 最高 | 容易 | 最高 | 最高 | 最低 | 最低 | 最低 | 最小 | 较优 |
2# | 最高 | 居中 | 居中 | 较难 | 最低 | 最差 | 最高 | 最高 | 居中 | 居中 | 略差 |
3# | 略低 | 略低 | 略低 | 居中 | 居中 | 居中 | 居中 | 居中 | 最高 | 最大 | 居中 |
Claims (10)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2008100168172A CN100509142C (zh) | 2008-06-11 | 2008-06-11 | 一种头孢菌素c提取专用大孔吸附树脂及其制备方法 |
EP09761282.4A EP2319618A4 (en) | 2008-06-11 | 2009-06-10 | MACROPOROUS RESIN FOR ADSORPTION SPECIFICALLY FOR THE EXTRACTION OF CEPHALOSPORIN C AND PREPARATION METHOD THEREOF |
US12/737,763 US20110288191A1 (en) | 2008-06-11 | 2009-06-10 | Macroporous absorbent resin for extracting cephalosporin c and method of preparation |
PCT/CN2009/072212 WO2009149657A1 (zh) | 2008-06-11 | 2009-06-10 | 一种头孢菌素c提取专用大孔吸附树脂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2008100168172A CN100509142C (zh) | 2008-06-11 | 2008-06-11 | 一种头孢菌素c提取专用大孔吸附树脂及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101288841A true CN101288841A (zh) | 2008-10-22 |
CN100509142C CN100509142C (zh) | 2009-07-08 |
Family
ID=40033393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2008100168172A Active CN100509142C (zh) | 2008-06-11 | 2008-06-11 | 一种头孢菌素c提取专用大孔吸附树脂及其制备方法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20110288191A1 (zh) |
EP (1) | EP2319618A4 (zh) |
CN (1) | CN100509142C (zh) |
WO (1) | WO2009149657A1 (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009149657A1 (zh) * | 2008-06-11 | 2009-12-17 | 山东鲁抗立科药物化学有限公司 | 一种头孢菌素c提取专用大孔吸附树脂及其制备方法 |
CN101987291A (zh) * | 2010-11-05 | 2011-03-23 | 山东鲁抗立科药物化学有限公司 | 一种大孔吸附树脂及其制备方法和应用 |
CN102125823A (zh) * | 2011-01-13 | 2011-07-20 | 中国科学院生态环境研究中心 | 一种去除挥发性有机污染物的大比表面积大孔容吸附树脂 |
CN103421025A (zh) * | 2012-05-21 | 2013-12-04 | 上海医药工业研究院 | 制备7α-甲氧基头孢菌素C的方法 |
CN104844744A (zh) * | 2015-03-30 | 2015-08-19 | 山东鲁抗立科药业有限公司 | 一种对头孢菌素c具有特异性吸附的树脂及其制备方法 |
CN105198762A (zh) * | 2015-08-31 | 2015-12-30 | 国药集团威奇达药业有限公司 | 酶裂解法生产7-氨基头孢烷酸结晶母液中有效成分的综合回收方法 |
CN108144589A (zh) * | 2017-12-26 | 2018-06-12 | 万华化学集团股份有限公司 | 一种树脂及其制备方法,以及使用该树脂处理废水的方法 |
CN110448998A (zh) * | 2019-09-11 | 2019-11-15 | 北京凯瑞英科技有限公司 | 一种硫酸二甲酯合成中废气处理***及方法 |
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US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
CN103265663B (zh) * | 2013-05-30 | 2015-04-22 | 广西民族大学 | 一种含葡萄糖基松香基大孔吸附树脂及其制备方法 |
CN103263899A (zh) * | 2013-06-04 | 2013-08-28 | 重庆大学 | 分离纯化白藜芦醇用的大孔吸附树脂的修饰方法 |
CN105866397A (zh) * | 2016-03-14 | 2016-08-17 | 陆书华 | 一种用于检验科的防污染检验装置 |
CN105618011A (zh) * | 2016-03-18 | 2016-06-01 | 安徽三联泵业股份有限公司 | 一种高弹性吸附树脂的制备方法 |
CN106311190B (zh) * | 2016-08-18 | 2018-11-23 | 佛山科学技术学院 | 多孔锰系锂离子筛吸附剂的制备方法 |
RU2653125C1 (ru) * | 2017-05-23 | 2018-05-07 | Акционерное общество "ПЕРСПЕКТИВНЫЕ МЕДИЦИНСКИЕ ТЕХНОЛОГИИ" | Полимерный сорбент, способ его получения и использования |
CN114405488B (zh) * | 2022-01-12 | 2023-08-25 | 江苏贝美医疗科技有限公司 | 一种蛋白结合类毒素血液灌流吸附剂及其制备方法与应用 |
CN114573864B (zh) * | 2022-03-23 | 2023-08-04 | 西安蓝深新材料科技股份有限公司 | 一种多孔吸附树脂及其制备方法和应用 |
CN115634673A (zh) * | 2022-12-07 | 2023-01-24 | 盱眙凹土能源环保材料研发中心 | 一种吸附胆红素的血液灌流用超高交联树脂的制备方法 |
Family Cites Families (16)
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BE756082A (fr) * | 1969-09-12 | 1971-03-11 | I Elementoorganiche Kih Soedin | Squelettes macroreticulaires de polystyrene pour resines echangeuses d'ions et leur procede de preparation ( |
US4263407A (en) | 1978-07-24 | 1981-04-21 | Rohm And Haas Company | Polymeric adsorbents from macroreticular polymer beads |
US4191813A (en) * | 1978-07-24 | 1980-03-04 | Rohm And Haas Company | Polymeric adsorbents from vinylbenzyl chloride copolymer beads |
JPS60163903A (ja) * | 1984-02-02 | 1985-08-26 | Mitsubishi Chem Ind Ltd | 架橋共重合体の多孔化方法 |
US4965083A (en) * | 1988-03-23 | 1990-10-23 | The Dow Chemical Company | Removal of bitterness from citrus juices using a post-crosslinked adsorbent resin |
JPH0418436A (ja) * | 1990-05-11 | 1992-01-22 | Mitsubishi Kasei Corp | 多孔性樹脂の製造方法 |
US5218004A (en) | 1990-08-16 | 1993-06-08 | Rohm And Haas Company | Process for enhancing the surface area of an adsorbent copolymer |
EP0496405A1 (en) * | 1991-01-25 | 1992-07-29 | Mitsubishi Kasei Corporation | Porous resin and process for its production |
US5416124A (en) * | 1994-06-21 | 1995-05-16 | The Dow Chemical Company | Polymeric adsorbents with enhanced adsorption capacity and kinetics and a process for their manufacture |
CN1131112C (zh) * | 2001-11-05 | 2003-12-17 | 南京大学环境学院 | 具有双重功能的超高交联弱碱阴离子交换树脂的合成方法 |
CN1660896A (zh) * | 2004-12-14 | 2005-08-31 | 天津南大日月生物科技有限公司 | 树脂法提取制备乳酸链球菌素的方法 |
CN100360239C (zh) * | 2005-07-14 | 2008-01-09 | 上海交通大学 | 大孔交联聚苯乙烯混合酸离子交换树脂及其制备方法 |
DE102006020874A1 (de) * | 2006-05-05 | 2007-11-08 | Lanxess Deutschland Gmbh | Verfahren zum Entfernen von Lösungsmitteln aus Perlpolymerisaten |
CN101088600A (zh) * | 2006-06-12 | 2007-12-19 | 天津协成昌国际贸易有限公司 | 一种吸附材料的制备方法及产品 |
CN100494231C (zh) * | 2007-02-09 | 2009-06-03 | 南开大学 | 筛分型吸附树脂的制备及在分离人参皂甙单体Rb1中的应用 |
CN100509142C (zh) * | 2008-06-11 | 2009-07-08 | 山东鲁抗立科药物化学有限公司 | 一种头孢菌素c提取专用大孔吸附树脂及其制备方法 |
-
2008
- 2008-06-11 CN CNB2008100168172A patent/CN100509142C/zh active Active
-
2009
- 2009-06-10 US US12/737,763 patent/US20110288191A1/en not_active Abandoned
- 2009-06-10 WO PCT/CN2009/072212 patent/WO2009149657A1/zh active Application Filing
- 2009-06-10 EP EP09761282.4A patent/EP2319618A4/en not_active Withdrawn
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009149657A1 (zh) * | 2008-06-11 | 2009-12-17 | 山东鲁抗立科药物化学有限公司 | 一种头孢菌素c提取专用大孔吸附树脂及其制备方法 |
CN101987291A (zh) * | 2010-11-05 | 2011-03-23 | 山东鲁抗立科药物化学有限公司 | 一种大孔吸附树脂及其制备方法和应用 |
CN101987291B (zh) * | 2010-11-05 | 2012-12-05 | 山东鲁抗立科药物化学有限公司 | 一种大孔吸附树脂及其制备方法和应用 |
CN102125823A (zh) * | 2011-01-13 | 2011-07-20 | 中国科学院生态环境研究中心 | 一种去除挥发性有机污染物的大比表面积大孔容吸附树脂 |
CN102125823B (zh) * | 2011-01-13 | 2013-01-16 | 中国科学院生态环境研究中心 | 一种去除挥发性有机污染物的大比表面积大孔容吸附树脂 |
CN103421025B (zh) * | 2012-05-21 | 2016-05-11 | 上海医药工业研究院 | 制备7α-甲氧基头孢菌素C的方法 |
CN103421025A (zh) * | 2012-05-21 | 2013-12-04 | 上海医药工业研究院 | 制备7α-甲氧基头孢菌素C的方法 |
CN104844744A (zh) * | 2015-03-30 | 2015-08-19 | 山东鲁抗立科药业有限公司 | 一种对头孢菌素c具有特异性吸附的树脂及其制备方法 |
CN104844744B (zh) * | 2015-03-30 | 2017-11-28 | 艾美科健(中国)生物医药有限公司 | 一种对头孢菌素c具有特异性吸附的树脂及其制备方法 |
CN105198762A (zh) * | 2015-08-31 | 2015-12-30 | 国药集团威奇达药业有限公司 | 酶裂解法生产7-氨基头孢烷酸结晶母液中有效成分的综合回收方法 |
CN105198762B (zh) * | 2015-08-31 | 2016-11-30 | 国药集团威奇达药业有限公司 | 酶裂解法生产7-氨基头孢烷酸结晶母液中有效成分的综合回收方法 |
CN108144589A (zh) * | 2017-12-26 | 2018-06-12 | 万华化学集团股份有限公司 | 一种树脂及其制备方法,以及使用该树脂处理废水的方法 |
CN108144589B (zh) * | 2017-12-26 | 2020-08-28 | 万华化学集团股份有限公司 | 一种树脂及其制备方法,以及使用该树脂处理废水的方法 |
CN110448998A (zh) * | 2019-09-11 | 2019-11-15 | 北京凯瑞英科技有限公司 | 一种硫酸二甲酯合成中废气处理***及方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100509142C (zh) | 2009-07-08 |
EP2319618A1 (en) | 2011-05-11 |
WO2009149657A1 (zh) | 2009-12-17 |
EP2319618A4 (en) | 2014-07-23 |
US20110288191A1 (en) | 2011-11-24 |
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Address after: 272073 Shandong city of Jining province high tech Zone Shixian Road No. 1688 Patentee after: AMICOGEN (CHINA) BIOPHARM CO.,LTD. Address before: 272073 Shandong city of Jining province high tech Zone East Ring Road Lukang Industrial Park Patentee before: SHANDONG LUKANG RECORD PHARMACEUTICALS Co.,Ltd. Address after: 272073 Shandong city of Jining province high tech Zone East Ring Road Lukang Industrial Park Patentee after: SHANDONG LUKANG RECORD PHARMACEUTICALS Co.,Ltd. Address before: 272000 Shandong city of Jining province high tech Zone East Ring Road Lukang Industrial Park Patentee before: Shandong Lukang Record Pharmaceutical Co.,Ltd. |