CN101275968A - Liquid aspirating tube, liquid dispensing apparatus and liquid dispensing method - Google Patents
Liquid aspirating tube, liquid dispensing apparatus and liquid dispensing method Download PDFInfo
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- CN101275968A CN101275968A CNA2008100848903A CN200810084890A CN101275968A CN 101275968 A CN101275968 A CN 101275968A CN A2008100848903 A CNA2008100848903 A CN A2008100848903A CN 200810084890 A CN200810084890 A CN 200810084890A CN 101275968 A CN101275968 A CN 101275968A
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Abstract
The invention provides a liquid dispensing apparatus which is capable of preventing contamination by previously aspirated liquid, even when residual liquid in a pipette tip separated from the dispensing apparatus is scattered, liquid dispensing method and liquid absorbing pipe. The liquid dispensing apparatus includes: a sample dispensing arm 5 which comprises a dispensing nozzle 54b for aspirating and discharging sample on which a pipette tip 200 is attached; a tip separating section 140 for separating the pipette tip 200 from the dispensing nozzle 54 b; and a nozzle wiping section 16 for cleaning a tip of the dispensing nozzle 54 b. A front end of the liquid absorbing pipe provided by the invention is provided with a suction hole that absorbs liquid in the pipette pipe adjacently. The pipette side is provided with an opening laterally. The liquid dispensing method includes: a step that mounts the pipette tip on the front end of the dispensing nozzle; a step that displacing the liquid in the liquid container to the pipette on the liquid dispensing nozzle; a step that injects the absorbed liquid to a target container; a step that dissembles the pipette from the nozzle and a step that cleans the front end of the dispensing nozzle.
Description
Technical field:
The present invention relates to a kind of liquid dispenser, dosing method and pipette that suction nozzle is used for liquid such as packing sample and reagent of assembling.
Background technology:
Being furnished with the analytical equipment that is used for inhaling the dosing mouth of irritating liquid such as sample such as blood and reagent, prevent when after emitting the liquid of suction, sucking other new liquid again that last time institute's imbibition body was sneaked into guaranteeing that analysis precision is very important.For this reason, open flat 6-3364 communique such as the spy and disclose a kind of liquid dispenser and can disposable volumetric pipette head (being designated hereinafter simply as suction nozzle) be installed, and dismounting more renews suction nozzle with suction nozzle at dosing mouth front end.
After the dosing mouth that the disclosed liquid dispenser of Te Kaiping 6-3364 communique will be equipped with suction nozzle inserts the breach of dockboard, on carry the dosing mouth, make and answer back to dockboard above the suction nozzle, suction nozzle is disassembled from the dosing mouth.
Yet, open the disclosed technology of flat 6-3364 communique according to the spy, when answering back to dockboard above the suction nozzle when suction nozzle is come off, the liquid that remains on the suction nozzle can splash dosing mouth front end.Sometimes liquid also can splash in the suction hole of dosing mouth front end.In case dosing mouth front end spatters the liquid that remains on the suction nozzle, even also can sneaking into, the replacing suction nozzle last time analyzed used liquid, analysis precision is descended.
For addressing this is that, when the liquid dispenser of recording and narrating on the Te Kaiping 11-248714 communique is dismantled suction nozzle from the mouth seat, the suction nozzle tapering part is touched from dosing mouth central shaft reach by moving down the dosing mouth apart from the head board of suction nozzle front end microspur, along with moving down of dosing mouth, apply the release power of a horizontal direction from head board to suction nozzle, make the annexation of suction nozzle and dosing mouth seat loosening.Promote dosing mouth seat then, make and answer back to stripper above the suction nozzle, suction nozzle is separated from dosing mouth seat.
In recent years, along with reduce collection of specimens amount such as blood sampling volume for relieve patient ' s burden, people require analytical equipment also will reduce and analyze needed specimen amount.And along with the increase of measuring sample quantity, the high speed of analytical equipment also is subjected to people's expectation day by day.
Reduce the collection of specimens amount, and carry out high-precision analysis, just must improve the micro quantitative determination of liquid dispenser, and suction nozzle also uses elongated shape more and more thereupon.Use this elongated shape suction nozzle, from dosing mouth dismounting suction nozzle the time, the angle that the tapering part of suction nozzle front end and Z-axis constitute is very little.If the spy is opened the technology of recording and narrating on the flat 11-248714 communique to be applied to use on the analytical equipment of this suction nozzle, then produce the problem of following three aspects: (1) because suction nozzle tapering part angle is very little, the thrust that be subjected to horizontal direction from head board along with the decline of suction nozzle just the front end of the suction nozzle front end of reduction and push pedal must be provided with very close to.For this reason, require push pedal that high-quality and high assembly precision is arranged, High Accuracy Control is arranged when also requiring to reduce the dosing mouth that suction nozzle is housed; (2) because suction nozzle tapering part angle is very little, the horizontal direction thrust decay that is subjected to from push pedal when suction nozzle descends, when answering back to stripper above the suction nozzle, residual liquid can produce and splash; (3) along with the high speed of liquid dispenser, the problem of (1) and (2) can be more outstanding.
Summary of the invention:
The invention provides a kind of liquid dispenser, comprising:
Liquid dispensing device has suction nozzle is used to inhale filling liquid in front end dosing mouth is installed;
The dismounting parts are used to make the suction nozzle that is contained on the dosing mouth to break away from from the dosing mouth; And
The mouth cleaning part is used to clean and has dismantled the dosing mouth front end behind the suction nozzle.
Described liquid dispensing device has the described dosing mouth that can move horizontally up and down; Described dismounting parts have touch panel, touch the suction nozzle upper end-face edge that is contained on the dosing mouth with the rising along with described dosing mouth, and suction nozzle is come off.
Described mouth cleaning part has polishing piece, brings in the described dosing mouth front end of cleaning before pushing described dosing mouth.Described polishing piece contains water-absorbing material.
Described liquid dispenser also comprises: the mobile controller of controlling described mobile device; Wherein, described mobile controller control described mobile device above described dosing mouth moves on to polishing piece after, reduce the dosing mouth, make dosing mouth front end by being pressed on the described polishing piece.
Described mobile controller is controlled described mobile device and is moved, and makes the dosing mouth push the position of described polishing piece and last time pressing position was different.
Described mobile controller is controlled moving of described mobile device, makes the dosing mouth push the position of described polishing piece as drawing circle at every turn.
Described mouth cleaning part has the resilient material that flexibly supports described polishing piece.
The following of described dosing mouth front end is plane.
Described dosing mouth comprises with the lower part: inhale the suction hole of moving liquid in described suction nozzle; And the splashproof device, be used to prevent to adhere to described suction hole from the liquid that the described suction nozzle that described dosing mouth disassembles splashes.
Be provided with near the described dosing mouth front end liquid is inhaled the suction hole that moves on in the described suction nozzle, this inhales the hole opening towards the side.Also have external diameter near the described dosing mouth front end than its all little up and down thin neck, described suction hole is opened in this thin neck place.
The present invention also provides a kind of sample analyzer, comprising: aforementioned liquid dispenser; The sample feeding mechanism of the specimen container that sample is housed is provided to the aspirating specimen position; And mensuration is contained in the determinator of the sample in the reaction vessel; Wherein, described liquid dispenser is inhaled sample in the suction nozzle that is contained on the described dosing mouth from described specimen container in described aspirating specimen position, in sample perfusion position sample is injected described reaction vessel again.
The present invention further provides a kind of dosing method, may further comprise the steps:
Suction nozzle is installed to the step of dosing mouth front end;
The liquid that is contained in the liquid container is inhaled the step that moves on in the suction nozzle that is contained on the dosing mouth;
The liquid that sucks is expelled to the step of target container;
Step from dosing mouth dismounting suction nozzle; And
The step of cleaning dosing mouth front end.
The present invention also provides a kind of front end dress suction nozzle to be used to inhale the pipette of moving liquid, is useful near the front end liquid is inhaled the suction hole that moves on in the suction nozzle, and this inhales the hole lateral openings.
Described pipette also comprises near its front end has external diameter than its all little up and down thin neck, and open at this thin neck place in wherein said suction hole.
Description of drawings:
The planimetric map of the immunoassay device that Fig. 1 relates to for an embodiment of the present invention;
Fig. 2 contains controller at interior block diagram for the determinator of the immunoassay device that an embodiment of the present invention relates to;
Fig. 3 is the structured flowchart of determinator controller shown in Figure 2;
The control device block diagram of the immunoassay device that Fig. 4 relates to for an embodiment of the present invention;
Fig. 5 is the front view (FV) of the suction nozzle installed of the sample packing arm of an embodiment of the present invention;
Fig. 6 is the structure sketch map of syringe and mouth thereof in the sample packing arm of an embodiment of the present invention;
Fig. 7 carries out the process flow diagram that the sample packing is handled for the determinator controller of the sample packing arm of use an embodiment of the present invention;
The front view (FV) of the mouth that Fig. 8 is had for the sample packing arm of an embodiment of the present invention;
Fig. 9 is the sectional view of mouth shown in Figure 8;
Figure 10 is the oblique view of the mouth swabbing pig of an embodiment of the present invention;
Figure 11 is the sectional view of mouth swabbing pig shown in Figure 10;
Figure 12 is the outboard profile that is used to illustrate the suction nozzle dismounting action on the sample packing arm that is installed to immunoassay device shown in Figure 1;
Figure 13 is the outboard profile that is used to illustrate the suction nozzle dismounting action on the sample packing arm that is installed to immunoassay device shown in Figure 1;
Figure 14 is the outboard profile that is used to illustrate the suction nozzle dismounting action on the sample packing arm that is installed to immunoassay device shown in Figure 1;
Figure 15 is pulled to the key diagram of the position on the mouth swabbing pig filter paper shown in Figure 10 for the sample packing arm mouth that shows immunoassay device shown in Figure 1;
Figure 16 is the mouth sectional view of other embodiments of the present invention; And
Figure 17 is the planimetric map of the releasing sheet of suction nozzle stripping attachment shown in Figure 1.
Embodiment:
Describe with regard to preferred implementation of the present invention with reference to the accompanying drawings below.
At first see figures.1.and.2, the one-piece construction of the immunity analysis instrument 1 that relates to regard to an embodiment of the present invention describes.
The immunity analysis instrument 1 that an embodiment of the present invention relates to is to carry out the instrument that various projects such as hepatitis B, hepatitis C, tumor marker and thyroid hormone detect with samples such as blood.This immunity analysis instrument 1 in the capture antibodies (R1 reagent) that magnetic particle (R2 reagent) is attached to combine with contained antigen in the samples such as blood to be measured afterwards, by being attracted to magnetic patch (not having a diagram) side of BF (Bound Free) separation vessel 14 (seeing figures.1.and.2), remove the R1 reagent of the capture antibodies that contains unreacted (Free) in conjunction with (Bound) antigen, capture antibodies and magnetic particle together.The antigen that makes the magnetic particle combination is with after labelled antibody (R3 reagent) combines, by being drawn onto the magnetic patch place of BF separation vessel 14, remove the R3 reagent of the labelled antibody that contains unreacted (Free) again in conjunction with (Bound) magnetic particle, antigen and labelled antibody together.Behind can be when the reacting luminous luminous host (R5 reagent) of interpolation, measure the luminous quantity that the reaction of labelled antibody and luminous host produces with labelled antibody.In this process, contained antigen or antibody in quantitative measurement and the sample that labelled antibody combines.
This immunity analysis instrument 1 comprises as depicted in figs. 1 and 2: determinator 2, be disposed at the sample conveyer (injector) 3 of determinator 2 fronts, the control device 4 that is made of PC (PC) that is connected with determinator 2 circuit.Determinator 2 is made of suction nozzle supply 30, emergency treatment sample suction nozzle forwarder 20, sample packing arm 5, mouth swabbing pig 16, reagent dispenser 6 and 7, reagent packing arm 8,9 and 10, primary first-order equation unit 11 and secondary reaction unit 12, reaction cup feeding mechanism 13, BF separation vessel 14 and detecting device 15.As shown in Figure 2, each mechanical hook-up (various sample packing arms and reagent dispenser 7 etc.) is controlled by the controller 2a that is arranged on determinator 2 in the determinator 2.The also controlled device 2a control of sample conveyer 3.The immunity analysis instrument 1 that present embodiment relates to mixes with other samples in order to prevent the samples such as blood that sample packing arm 5 sucks and pours into, and each the suction when irritating sample all changed disposable tip 200 (with reference to Fig. 5).Each several part structure about determinator 2 illustrates in the back.
CPU2b can carry out computer program that is stored in ROM2c and the computer program of reading among the RAM2d.Needed data etc. when ROM2c is storing the computer program carried out by CPU2b and computer program.RAM2d is used to read the computer program that is stored in ROM2c.Work space in the time of can also carrying out these computer programs as CPU2b.
Sample conveyer 3 can be transported to the test tube rack 101 of placing several test tubes 100 of dress sample with sample packing arm 5 and inhale the corresponding position of suction displacement 1a of moving sample as shown in Figure 1.This sample conveyer 3 has test tube rack rest area 3a and test tube rack harvesting district 3b, wherein test tube rack rest area 3a is used for placing the test tube rack 101 of the test tube 100 of adorning the sample that is untreated, and test tube rack harvesting district 3b is used to deposit the test tube rack 101 that dress has been handled the test tube 100 of sample.The be untreated test tube 100 of sample of dress is transported to sample packing arm 5 and inhales displacement 1a relevant positions, sample packing arm 5 can be inhaled move the samples such as blood in the test tube 100, and the test tube rack 101 of placing this test tube 100 then is stored in test tube rack storage area 3b.Each test tube 100 posts the bar code that is writing down the identifying information that is used to discern the sample of adorning.Being placed on test tube 100 on the test tube rack 101 of test tube rack rest area 3a is read to be transported to behind each identifying information by no illustrated bar code reader and inhales the 1a that is shifted.
Control device 4 (with reference to Fig. 1) comprises controller 4a, the display 4b and the keyboard 4c that are made up of CPU, ROM and RAM etc. by PC formations such as (PC).Display 4b is mainly used in the digital signal data income analysis result of display analysis detecting device 15 transmission etc.
Structure with regard to control device 4 describes below.Control device 4 as shown in Figure 4, the computing machine of mainly being made up of controller 4a, display 4b and keyboard 4c 401 constitutes.Controller 4a mainly is made of CPU401a, ROM401b, RAM401c, hard disk 401d, reading device 401e, input and output interfaces 401f, communication interface 401g and image output interface 401h.CPU401a, ROM401b, RAM401c, hard disk 401d, reading device 401e, input and output interfaces 401f, communication interface 401g and image output interface 401h are connected by bus 401i.
CPU401a can carry out the computer program that the computer program that is stored in ROM401b and RAM401c read.Computing machine 401 is carried out the effect of aftermentioned application program 404a performance control device 4 by CPU401a.
ROM401b is made of ROM (read-only memory), PROM, EPROM, EEPROM etc., computer program that storage is carried out by CPU401a and used data thereof etc.
RAM401c is made of SRAM or DRAM etc., is used to read the computer program that is stored in ROM401b and hard disk 401d.Work space in the time of can also carrying out these computer programs as CPU401a.
Above-mentioned application program 404a not only can be provided by pocket storage medium 404, also can connect by this electronic communication circuit of electronic communication line route (no matter wired, wireless), can with external mechanical that computing machine 401 is communicated by letter on provide.Such as, when above-mentioned application program 404a was stored in the hard disk of the webserver, computing machine 401 addressable these servers were downloaded this application program 404a, and hard disk 401d packs into.
Input and output interfaces 401f is by constituting such as parallel interfaces such as serial line interfaces such as USB, IEEE1394, RS-232C, SCSI, IDE, IEEE1284 and the analog signal interface be made up of D/A converter and A/D converter etc.Input and output interfaces 401f meets keyboard 4c, and the user can be with keyboard 4c directly to computing machine 401 input data.
Below, describe with regard to determinator 2 each several part structures.The effect of suction nozzle supply 30 (with reference to Fig. 1) is that a large amount of suction nozzles 200 that will be placed on suction nozzle container (not having diagram) pursue-are transported to emergency treatment sample suction nozzle forwarder 20.Emergency treatment sample suction nozzle forwarder 20 can be transported to the test tube 102 that the emergency treatment sample that detects in the sample that needs insertion sample conveyer 3 to transport is housed the suction nozzle 200 installation position 1b (with reference to Fig. 1) of sample packing arm 5.The suction nozzle 200 that emergency treatment sample suction nozzle forwarder 20 also is used for receiving from suction nozzle supply 30 is transported to the installation position 1b of sample packing arm 5.
The effect of sample packing arm 5 is, packing sample conveyer 3 is transported to the sample in the test tube 102 that sample in the test tube 100 of inhaling displacement 1a (with reference to Fig. 1) or emergency treatment sample suction nozzle forwarder 20 transport to installation position 1b (with reference to Fig. 1) in the reaction cup 150 of the turntable 11a fixed bit 11b that is fixed on aftermentioned primary first-order equation unit 11.This sample packing arm 5 has motor 51, connects the drive transmission systems 52 of motor 51 and is installed in the arm 54 on the drive transmission systems 52, the arm support 55 of sway brace 54 and the horizontal drive apparatus 56 of horizontal direction transfer arm support 55 by axle 53 as shown in Figure 1.It is the center rotation with axle 53 that drive transmission systems 52 leans on the driving of motor 51 can make arm 54, and (Z direction) moves up and down.Shown in Fig. 6, Figure 12 etc., arm 54 has syringe 54a and mouth 54b.Syringe 54a has the pump 54c that inhale to irritate sample, as the motor 54d and the pressure acquisition sensor 54e of pump 54c drive source.Pump 54c can be that piston motion obtains to inhale the filling function by the rotational transform with motor 54d.Pressure acquisition sensor 54e is used to survey pump 54c and inhales the pressure of irritating when operating.
As Fig. 8 and shown in Figure 9, mouth 54b comprises mouth body 54k and front end 54f, forms on the central shaft of the inherent mouth 54b of mouth 54b and inhales advection road 54i.Mouth body 54k and front end 54f shape of cross section are circular.The suction nozzle 200 that the conveyer frames 23 (with reference to Fig. 1) of front end 54f installation emergency treatment sample suction nozzle forwarder 20 sends.The front end 54f of mouth 54b have an external diameter than its all little up and down slightly cylindrical circular thin neck 54g with one from following and thin neck 54g is connected, external diameter is bigger than the external diameter of thin neck 54g slightly cylindrical circular terminal 54j.The side of thin neck 54g is provided with two and is used for sample is sucked suction hole 54h in the suction nozzle 200 that is contained in mouth 54b front end 54f towards lateral openings.Inhale hole 54h and be communicated to pump 54c by the suction advection road 54i in the mouth 54b.Inhale hole 54h for two and omit linearly shape by inhaling advection road 54i at thin neck 54g.Promptly as shown in Figure 9, inhale that hole 54h inhales advection road 54i on the section of front end 54f and two suction hole 54h slightly are inverted T-shape.Below the terminal 54j is the plane.
The effect of mouth swabbing pig 16 (with reference to Fig. 1, Figure 10 and Figure 11) is the sample that adheres to when erasing the sample packaging operation below the terminal 54j of sample packing arm 5 mouth 54b front end 54f.This mouth swabbing pig 16 as shown in Figure 10 and Figure 11, filter paper 16a is arranged, put filter paper 16a filter paper lay down location 16b, opening 16i, with filter paper 16a be fixed to filter paper lay down location 16b fixture 16c, support support 16d, spring 16e, outer wall 16f and the base 16j of filter paper lay down location 16b.Filter paper lay down location 16b, support 16d and spring 16e are all in the space that is formed by outer wall 16f and base 16j.Base 16j is fixed on the outer wall 16f by screw (not having diagram).Fixture 16c medial surface and filter paper lay down location 16b lateral surface have spiral groove (do not have diagram) respectively, fixture 16c by rotational fixation at filter paper lay down location 16b.Because fixture 16c is fixed on filter paper lay down location 16b, the filter paper 16a fixture 16c that is placed on the filter paper lay down location 16b fixes.Support 16d has recess 16g, and recess 16h is also arranged above the base 16j.Spring 16e one end embeds the recess 16g of support 16d, and the other end embeds the recess 16h of base 16j, is positioned at the space that is formed by outer wall 16f and base 16j.Thus, filter paper lay down location 16b and support 16d are subjected to the acting force reverse with base 16j from spring 16e.Filter paper lay down location 16b and support 16d are restricted by the protuberance 16k that props up on the outer wall 16f owing to the protuberance on the filter paper lay down location 16b (not having diagram) that moves that acting force produced of spring 16e.
Suction nozzle stripping attachment 140 (with reference to Fig. 1, Figure 12) is used to dismantle the suction nozzle 200 that is contained on the sample packing arm 5.Suction nozzle stripping attachment 140 has vertical direction (Z direction) to extend and the sheet metal 141 established, the resin system on the sheet metal 141 of being contained in are removed sheet 142 and reclaim the suction nozzle recover (not having diagram) of the suction nozzle 200 that disassembles as shown in figure 12.Remove sheet 142 as shown in figure 17, have a diameter littler than suction nozzle 200 installation portion 200c (with reference to Fig. 5), than the big hole 142a of the arm 54 front end 54f (with reference to Figure 14) of sample packing arm 5 with is connected with hole 142a, for the hole 142b of the mouth 54b that suction nozzle 200 is housed from the top insertion.
Reagent dispenser 6 (with reference to Fig. 1) is used to place the reagent bottle that holds the R1 reagent that contains capture antibodies and contains the reagent bottle of the R3 reagent of labelled antibody.
Reagent dispenser 7 (with reference to Fig. 1) is used to place the reagent bottle that holds the R2 reagent that contains magnetic particle.
Reaction cup feeding mechanism 13 (with reference to Fig. 1) can be supplied several reaction cup 150 to the turntable 11a of primary first-order equation unit 11 fixed bit 11b successively.
Primary first-order equation unit 11 (with reference to Fig. 1) is used to make the reaction cup 150 that is fixed on turntable 11a fixed bit 11b to turn an angle at regular intervals, simultaneously sample, R1 reagent and the R2 reagent in the stirring reaction cup 150.This primary first-order equation unit 11 has
The fortune cupule11c, the reaction cup 150 that is used for to R1 reagent and R2 reagent to be housed is transported to aftermentioned BF separation vessel 14.
The effect of reagent packing arm 8 (with reference to Fig. 1) is to inhale the R1 reagent that moves in the reagent bottle that is placed on reagent dispenser 6, and the R1 reagent branch that suction moves is installed in the reaction cup 150 of the turntable 11a fixed bit 11b that divides the primary first-order equation unit 11 that sample is housed.
The effect of reagent packing arm 9 (with reference to Fig. 1) is that the R2 reagent branch that will be placed in the reagent bottle of reagent dispenser 7 installs in the reaction cup 150 of dividing the primary first-order equation unit 11 that sample and R1 reagent are housed.
Secondary reaction unit 12 (with reference to Fig. 1) has the structure same with primary first-order equation unit 11, be used to make the reaction cup 150 that is fixed on turntable 12a fixed bit 12b to turn an angle at regular intervals, simultaneously sample, R1 reagent, R2 reagent, R3 reagent and the R5 reagent in the stirring reaction cup 150.This secondary reaction unit 12 has
The fortune cupule12c is used for the reaction cup 150 that sample through stirring etc. is housed is delivered to BF separation vessel 14.
The fortune cupule12c can also transport the reaction cup of handling through BF separation vessel 14 150 back turntable 12a fixed bit 12b once more.
The effect of reagent packing arm 10 (with reference to Fig. 1) is to inhale the R3 reagent that moves in the reagent bottle that is placed on reagent dispenser 6, and the R3 reagent branch that suction moves is installed in the reaction cup 150 of dividing the primary first-order equation unit 11 that sample, R1 reagent and R2 reagent are housed.Reagent packing arm 10 also is used for installing in the reaction cup 150 that sample, R1 reagent, R2 reagent and R3 reagent are housed of secondary reaction unit 12 being arranged on the R5 reagent branch that no illustrated reagent bottle below the immunity analysis instrument 1 includes luminous host.
Detecting device 15 (with reference to Fig. 1) detects by photomultiplier (Photo Multiplier Tube) and is attached to through the labelled antibody of the sample antigen of certain processing and the light that luminous host sends in course of reaction, measures contained antigen amount in this sample.
When carrying out sample packing processing, controller 2a requires customized information according to the identifying information of the test tube 100 that bar code reader reads to the controller 4a of control device 4, and slave controller 4a receives customized information.Customized information stores control device 4 into by the principal computer that connects control device 4 (not having diagram) login or by the artificial input of user.Controller 2a judges whether sample to be packed (step S1) according to the customized information that slave controller 4a receives.If not carrying out the sample packing, no sample to be packed, controller 2a do not handle.
Operate the power supply (not having diagram) of connecting determinator 2 by the user, assign to measure and begin indication, then controller 2a carries out initialization to sample packing arm 5, makes the arm 54 mouth 54b of sample packing arm 5 move to suction nozzle stripping attachment 140 tops as initial position.Controller 2a is when judging that in the processing of step S1 sample to be packed is arranged, then control emergency treatment sample suction nozzle forwarder 20 suction nozzle 200 is moved to installation position 1b, the arm 54 mouth 54b of sample packing arm 5 are moved on to installation position 1b (step S2) from suction nozzle stripping attachment 140 tops as initial position.Controller 2a allows arm 54 descend, and mouth 54b front end 54f is pushed suction nozzle 200 installation portion 200c, suction nozzle 200 is installed to the mouth 54b of arm 54.(step S3).
Next, after controller 2a lifts the arm 54 mouth 54b of sample packing arm 5, arm 54 mouth 54b are moved to as the suction of aspirating specimen position displacement 1a (with reference to Fig. 1) (step S4).Controller 2a reduces arm 54 again, and control arm 54 will be transported to aspirating specimen in the test tube 100 of inhaling displacement 1a to the suction nozzle 200 interior (step S5) that is contained in mouth 54b front end 54f by sample conveyer 3 then.
Afterwards, controller 2a rising arm 54 moves on to arm 54 mouth 54b the turntable 11a fixed bit 11b top (step S6) of primary first-order equation unit 11.Controller 2a reduces arm 54 again, sample is injected the reaction cup 150 (step S7) of the turntable 11a fixed bit 11b that is fixed in primary first-order equation unit 11.
Next, after controller 2a lifts arm 54, mouth 54b is moved on to the hole 142b top of the releasing sheet 142 of suction nozzle stripping attachment 140.Controller 2a reduces arm 54 again, will be equipped with in the hole 142b that mouth 54b with suction nozzle 200 inserts suction nozzle stripping attachment 140 (step S8).Mouth 54b in the patchhole 142b moves to hole 142a below, dismounting position by controller 2a controlling level as shown in figure 12.Then, mouth 54b is risen by controller 2a control, along with the vertical motion of mouth 54b, as shown in figure 13, contacts below removing sheet 142 above the suction nozzle 200 installation portion 200c.And for example shown in Figure 14, suction nozzle 200 breaks away from mouth 54b front end 54f (step S9).
Then, controller 2a moves on to mouth swabbing pig 16 (with reference to Fig. 1) top (step S10) with arm 54 mouth 54b.Controller 2a reduces arm 54, and the terminal 54j of mouth 54b front end 54f is gone up (step S11) by the filter paper 16a that is pressed in mouth swabbing pig 16.
After controller 2a lifts arm 54, the mouth 54b of sample packing arm 5 is moved to the top (step S12) of initial position suction nozzle stripping attachment 140.After the processing of step S12, controller 2a carries out the processing of step S1 once more.
More than be illustrated for inhaling the example move the sample in the test tube 100 that sample conveyer 3 transports.When checking the emergency treatment sample, controller 2a forwards the mouth 54b of the arm 54 of sample packing arm 5 to installation position 1b (with reference to Fig. 1) in the processing of step S4.Controller 2a is in the processing of step S5, and control arm 54 is transported to emergency treatment sample suction nozzle forwarder 20 aspirating specimen in the test tube 102 of installation position 1b in the suction nozzle 200 that is installed on the mouth 54b front end 54f.
In the processing of step S9, the bump that produces when breaking away from mouth 54b front end 54f with suction nozzle 200 might make the sample that remains on the suction nozzle 200 be splashed to below the terminal 54j of mouth 54b front end 54f.In the present embodiment, since the processing of step S11 be terminal 54j with mouth 54b front end 54f by being pressed on the filter paper 16a, therefore, even sample adheres to below the terminal 54j, can prevent conscientiously that also the sample that last time used from sneaking in the next sample, thereby be improved the reliability of measuring precision.
In the present embodiment, inhale move sample suction hole 54h at mouth 54b front end 54f to lateral opening.Therefore, even the sample that dismounting remains on the suction nozzle 200 during suction nozzle splashes, sample also can splash from mouth 54b below, is avoided sample to be attached to and inhales 54h inside, hole.Therefore, can prevent to sneak into other samples that are used for next analysis, and prevent to detect the pressure acquisition sensor 54e misoperation of inhaling hole 54h internal pressure attached to the sample of inhaling in the 54h of hole.
In the present embodiment, inhale hole 54h and be opened in external diameter, can prevent more conscientiously that therefore sample from adhering in the suction hole 54h than its all little up and down thin neck 54g place.
In the present embodiment, having the thin neck 54g below of inhaling hole 54h has an external diameter slightly cylindrical circular terminal 54j bigger than thin neck 54g external diameter, can prevent more conscientiously that sample from adhering in the suction hole 54h.
In the present embodiment, be planar shaped below the terminal 54j of mouth 54b front end 54f.Therefore, in the processing of step S11, when the filter paper 16a that the terminal 54j of mouth 54b front end 54f is against mouth swabbing pig 16 goes up, below the terminal 54j whole with uniform power by being pressed on the filter paper 16a.Like this, be easy to wipe attached to the sample below the terminal 54j.Because smooth below the terminal 54j, clean below the terminal 54j during other cleaning devices beyond the mouth swabbing pig 16 also easy to use.
In the present embodiment, in the processing of step S10 and step S11, controller 2a control sample packing arm 5 moves, and it is different with pressing position last time to make mouth 54b front end 54f push the position of mouth swabbing pig 16 filter paper 16a.Particularly, as shown in figure 15, moving of controller 2a control sample packing arm 5 makes mouth 54b front end 54f push the position (P) of filter paper 16a as drawing circle.Can prevent that so not only the sample that mouth 54b is attached on filter paper 16a from polluting once more, also can prolong the term of life of filter paper 16a, reduce and change the paper frequency.
In the present embodiment, mouth swabbing pig 16 has spring 16e, and spring 16e is from following supporting bracket 16d and lay down location 16b.Therefore, in the processing of step S11, when mouth 54b front end 54f pushed filter paper 16a, the lay down location 16b and the support 16d of mouth swabbing pig 16 also can move down.The reacting force that mouth 54b front end 54f is subjected to from lay down location 16b and support 16d in the time of can reducing mouth 54b front end 54f thus and push filter paper 16a, thus can prevent that mouth 54b front end 54f is by 16 damages of mouth swabbing pig.
In the present embodiment, the thin neck 54g place of mouth 54b has inhales hole 54h, open near the mouth front end rather than thin neck place but inhale the hole, and lateral openings also can.Such as, mouth 55b is such as shown in figure 16, and offer mouth at the front end 55f place of whole same outer diameter as also passable towards the suction hole 55g of side.
In the present embodiment, mouth 54b is provided with mouth towards the suction hole 54h that side direction is opened, and inhaling the hole also can downwardly facing opening.
In the present embodiment, the thin neck 54g of mouth 54b is provided with two and inhales hole 54h, inhales the hole for one and also can.Inhaling the hole also can more than three.
In the present embodiment, in the processing of step S11, move down mouth 54b, mouth 54b front end 54f is pressed on the filter paper 16a, wipe sample with this, but the invention is not restricted to this attached to mouth 54b front end 54f.Such as also the hygroscopic strip material that has that is contained on the running roller being contacted mouth 54b front end 54f Face to face, rotate this running roller, roll up this strip material, wipe sample with this attached to the mouth front end.Also can clean mouth 54b front end 54f and remove sample with being contained in clean-out system in the container attached to mouth 54b front end 54f.In the case, can dry, also can wiping attached to the clean-out system of mouth 54b front end 54f.
In the illustration of present embodiment, the mouth 54b front end 55f of sample packing arm 5 has mouthful suction hole 55g towards side direction.Also can will inhale the aperture towards laterally opening near the mouth front end of reagent packing arm.
In the present embodiment, by the mouth 54b of mouth swabbing pig 16 cleaning sample packing arms 5, also can dispose the cleaning device of cleaning reagent packing arm mouth.
In the present embodiment, mouth swabbing pig 16 has spring, and spring other elastic elements in addition also can be arranged.
In the present embodiment, in order to prevent that more conscientiously sample to inhaling the adhesion of hole 54h, is provided with external diameter than the big terminal 54j of thin neck 54g external diameter below being provided with the thin neck 54g that inhales hole 54h, the invention is not restricted to this.Such as when the suction hole is not located at thin neck place, external diameter also can be set by the front end at mouth 54b prevents that than the big parts of mouth 54b front end 54f external diameter sample is to inhaling the adhesion in hole.
Claims (16)
1. liquid dispenser comprises:
Liquid dispensing device has suction nozzle is used to inhale filling liquid in front end dosing mouth is installed;
The dismounting parts are used to make the suction nozzle that is contained on the dosing mouth to break away from from the dosing mouth; And
The mouth cleaning part is used to clean and has dismantled the dosing mouth front end behind the suction nozzle.
2. liquid dispenser as claimed in claim 1 is characterized in that:
Described liquid dispensing device has the described dosing mouth that can move horizontally up and down;
Described dismounting parts have touch panel, touch the suction nozzle upper end-face edge that is contained on the dosing mouth with the rising along with described dosing mouth, and suction nozzle is come off.
3. liquid dispenser as claimed in claim 2 is characterized in that: described mouth cleaning part has polishing piece, brings in the described dosing mouth front end of cleaning before pushing described dosing mouth.
4. liquid dispenser as claimed in claim 3 is characterized in that: described polishing piece contains water-absorbing material.
5. liquid dispenser as claimed in claim 3 is characterized in that also comprising: the mobile controller of controlling described mobile device; Wherein, described mobile controller control described mobile device above described dosing mouth moves on to polishing piece after, reduce the dosing mouth, make dosing mouth front end by being pressed on the described polishing piece.
6. liquid dispenser as claimed in claim 5 is characterized in that: described mobile controller is controlled described mobile device and is moved, and makes the dosing mouth push the position of described polishing piece and last time pressing position was different.
7. liquid dispenser as claimed in claim 5 is characterized in that: described mobile controller is controlled moving of described mobile device, makes the dosing mouth push the position of described polishing piece as drawing circle at every turn.
8. as liquid dispenser as described in the claim 3, it is characterized in that: described mouth cleaning part has the resilient material that flexibly supports described polishing piece.
9. liquid dispenser as claimed in claim 3 is characterized in that: the following of described dosing mouth front end is plane.
10. liquid dispenser as claimed in claim 1 is characterized in that:
Described dosing mouth comprises with the lower part:
In described suction nozzle, inhale the suction hole of moving liquid; And
The splashproof device is used to prevent to adhere to described suction hole from the liquid that the described suction nozzle that described dosing mouth disassembles splashes.
11. as arbitrary described liquid dispenser among the claim 1-10, it is characterized in that: be provided with near the described dosing mouth front end liquid is inhaled the suction hole that moves on in the described suction nozzle, this inhales the hole opening towards the side.
12. liquid dispenser as claimed in claim 11 is characterized in that: also have external diameter near the described dosing mouth front end than its all little up and down thin neck, described suction hole is opened in this thin neck place.
13. a sample analyzer comprises:
The described liquid dispenser of claim 1;
The sample feeding mechanism of the specimen container that sample is housed is provided to the aspirating specimen position; And
Mensuration is contained in the determinator of the sample in the reaction vessel;
Wherein, described liquid dispenser is inhaled sample in the suction nozzle that is contained on the described dosing mouth from described specimen container in described aspirating specimen position, in sample perfusion position sample is injected described reaction vessel again.
14. a dosing method may further comprise the steps:
Suction nozzle is installed to the step of dosing mouth front end;
The liquid that is contained in the liquid container is inhaled the step that moves on in the suction nozzle that is contained on the dosing mouth;
The liquid that sucks is expelled to the step of target container;
Step from dosing mouth dismounting suction nozzle; And
The step of cleaning dosing mouth front end.
15. a front end dress suction nozzle is used to inhale the pipette of moving liquid, it is characterized in that: be useful near the front end liquid is inhaled the suction hole that moves on in the suction nozzle, this inhales the hole lateral openings.
16. pipette as claimed in claim 15 is characterized in that also comprising: external diameter is arranged than its all little up and down thin neck near its front end, open at this thin neck place in wherein said suction hole.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410151071.1A CN103913585B (en) | 2007-03-30 | 2008-03-28 | Liquid dispenser, dosing method and pipette |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007-094429 | 2007-03-30 | ||
| JP2007-094563 | 2007-03-30 | ||
| JP2007094429A JP4949109B2 (en) | 2007-03-30 | 2007-03-30 | Liquid dispensing apparatus, sample measuring apparatus, and liquid dispensing method |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410151071.1A Division CN103913585B (en) | 2007-03-30 | 2008-03-28 | Liquid dispenser, dosing method and pipette |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101275968A true CN101275968A (en) | 2008-10-01 |
Family
ID=39974754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100848903A Pending CN101275968A (en) | 2007-03-30 | 2008-03-28 | Liquid aspirating tube, liquid dispensing apparatus and liquid dispensing method |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP4949109B2 (en) |
| CN (1) | CN101275968A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102356318A (en) * | 2009-03-18 | 2012-02-15 | 希森美康株式会社 | Specimen analyzer |
| CN106841645A (en) * | 2017-01-06 | 2017-06-13 | 刘丹 | One kind reaction incubating device, immunity analysis instrument and reaction incubation method |
| CN112298795A (en) * | 2019-07-30 | 2021-02-02 | 株式会社岛津制作所 | Separate injection head support |
| CN114054115A (en) * | 2020-07-31 | 2022-02-18 | 深圳市帝迈生物技术有限公司 | Sample adding method and device, computer storage medium and sample analysis device |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112236680A (en) * | 2018-06-21 | 2021-01-15 | 株式会社日立高新技术 | Automatic analyzer |
| JP6863437B2 (en) * | 2019-11-20 | 2021-04-21 | 株式会社島津製作所 | Liquid storage container and pretreatment equipment using the liquid storage container |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS62184359A (en) * | 1986-02-07 | 1987-08-12 | Seiko Instr & Electronics Ltd | Method for cutting liquid drop of pipette and method for wiping away liquid sticking to pipette |
| JPS62184361A (en) * | 1986-02-10 | 1987-08-12 | Nitsuteku:Kk | Pipette instrument |
| JPH0736241B2 (en) * | 1987-02-05 | 1995-04-19 | 松下電器産業株式会社 | Magnetic recording / reproducing device |
| JP2003315351A (en) * | 2002-04-19 | 2003-11-06 | Nittec Co Ltd | Infinitesimal blood automatic analytical device |
| JP4417021B2 (en) * | 2003-04-14 | 2010-02-17 | アロカ株式会社 | Liquid suction / discharge device |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102356318A (en) * | 2009-03-18 | 2012-02-15 | 希森美康株式会社 | Specimen analyzer |
| CN102356318B (en) * | 2009-03-18 | 2014-02-19 | 希森美康株式会社 | Specimen analyzer |
| US9250255B2 (en) | 2009-03-18 | 2016-02-02 | Sysmex Corporation | Sample analyzer |
| US10054605B2 (en) | 2009-03-18 | 2018-08-21 | Sysmex Corporation | Sample analyzer |
| CN106841645A (en) * | 2017-01-06 | 2017-06-13 | 刘丹 | One kind reaction incubating device, immunity analysis instrument and reaction incubation method |
| WO2018126772A1 (en) * | 2017-01-06 | 2018-07-12 | 深圳迎凯生物科技有限公司 | Reaction incubation device, immunity analyzer and reaction incubation method |
| US11619642B2 (en) | 2017-01-06 | 2023-04-04 | Shenzhen Increcare Biotech Co., Ltd. | Reaction incubation device, immunity analyzer and reaction incubation method |
| CN112298795A (en) * | 2019-07-30 | 2021-02-02 | 株式会社岛津制作所 | Separate injection head support |
| CN114054115A (en) * | 2020-07-31 | 2022-02-18 | 深圳市帝迈生物技术有限公司 | Sample adding method and device, computer storage medium and sample analysis device |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008249651A (en) | 2008-10-16 |
| JP4949109B2 (en) | 2012-06-06 |
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Application publication date: 20081001 |