CN101274006B - Pharmaceutical combination of prepotency for preventing birth-defect and improving memory - Google Patents
Pharmaceutical combination of prepotency for preventing birth-defect and improving memory Download PDFInfo
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- CN101274006B CN101274006B CN2008101123018A CN200810112301A CN101274006B CN 101274006 B CN101274006 B CN 101274006B CN 2008101123018 A CN2008101123018 A CN 2008101123018A CN 200810112301 A CN200810112301 A CN 200810112301A CN 101274006 B CN101274006 B CN 101274006B
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- vitamin
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- rhizoma atractylodis
- atractylodis macrocephalae
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Abstract
The invention relates to a pharmaceutical composition for healthy birth and scientific nurture, preventing birth defects and improving memory, which comprises large-headed atractylodes rhizome, vitamin A, Beta-carotene, compound vitamin B, vitamin C, vitamin D and vitamin E and is mainly applicable to pre-pregnant women, pregnant women and lactating mothers. The pharmaceutical composition is extremely effective in healthy birth and scientific nurture, preventing birth defects and improving memory and has efficacies of health care and invigoration, without any side effect for long-term use.
Description
Technical field:
The present invention relates to the Medicines and Health Product technical field.In particular for prenatal and postnatal care prevention birth defect and the pharmaceutical composition that improves memory.
Background technology:
Birth defect is meant fetus in parent and in the organ formative process of birth back, and is disorderly by embryo due to the various factors effect and paedomorphosis, comprises that morphosis is unusual, 4 types of physiological metabolism obstacle, congenital mental retardation and intrauterine growth retardations etc.Various countries' birth defect incidence rate is up to about 5% of the birth sum, and is great to the population quality influence, causes white elephant for family, society, become the common great public health problem of paying close attention in the present whole world.
The pathogenic factors of birth defect is very complicated, and inherited genetic factors is arranged, and environmental factors also has other multiple uncertain factor.Environmental factors comprises biological factor, physical factor, chemical factor; The embryo receives the injury of environment harmful factor and other multiple uncertain factor, the birth defect sickness rate is increased, and eliminate these harmful factors, and the birth defect sickness rate is lowered.
Pharmaceutical composition of the present invention is a policy of following prenatal and postnatal care; Through eliminating the birth defect factor that causes to the embryo, the generation of prevention birth defect reaches the purpose that lowers the birth defect sickness rate; Simultaneously user there is the memory impairments of improvement, favourable mothers and sons two generations's health; Said composition comprises the Rhizoma Atractylodis Macrocephalae and vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E.
The Rhizoma Atractylodis Macrocephalae is a kind of QI invigorating class natural Chinese medicine, and invigorating the spleen and benefiting QI is arranged, the dampness diuretic, the hidroschesis consolidating superficial resistance and in antiabortive effect; Ancient Chinese medicine is classified the Rhizoma Atractylodis Macrocephalae as on Chinese medicine article, antiabortive monarch drug, the panacea of fetus nourishing; The modern clinical cirrhotic ascites that are used for more, diarrhoea, Mo Niai syndrome, edema spontaneous perspiration, frequent fetal movement etc.; Modern pharmacological research confirms: 1, Rhizoma Atractylodis Macrocephalae Wheat Protein, can alleviate lipid peroxidation, and reduce the content of peroxide, avoid the destruction of harmful substance pair cell 26S Proteasome Structure and Function; And SOD activity improving trend is arranged, and enhancing body is to the ability of free radical scavenging, thus the damage of minimizing radical pair body.2, the Rhizoma Atractylodis Macrocephalae has delaying senility function, and Rhizoma Atractylodis Macrocephalae decoct can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppresses the brain activity of monoamine oxidase simultaneously, can also suppress erythrocytic autoxidation haemolysis, directly removes free radical, shows anti-aging effects.3, the Rhizoma Atractylodis Macrocephalae has the enhance immunity effect, and oral lymhocyte transformation rate and the serum IgG content of making of Rhizoma Atractylodis Macrocephalae decoct significantly rises, and shows that the Rhizoma Atractylodis Macrocephalae has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system.4, anticancer tumor effect, Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to the ehrlich ascites tumor cell; And external the Eca109 esophageal cancer cell is presented inhibition, can make cell detachment, karyopycnosis; Chromatin concentrates, and cell does not divide or seldom division.5, the Rhizoma Atractylodis Macrocephalae also has the blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function promotes the brood weight increase, physical potentiation raises to can be made leukocyte count by the leukopenia that causes after chemotherapy or the radiotherapy tumor.Traditional Chinese medical science custom in prescription the compatibility Rhizoma Atractylodis Macrocephalae to promote the absorption of medicine active ingredient.
Vitamin A is also claimed retinol, and the effect that improves vision, prevents nyctalopia is arranged, and the anemia of pregnant woman of enhancing Abwehrkraft des Koepers function is arranged, and can promote mucopolysaccharide synthetic, influences renewal, the growth of osseous tissue, and long bone is grown to both-end; If VAD is prone to premature labor or fetal congenital deformity.Beta-carotene can change vitamin A under the effect of enzyme in vivo, the effect of performance vitamin A.
Vitamin B group is participated in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid etc., collaborative in vivo performance physiological action.Vitamin B
1Have the effect of keeping the nervous system normal function, phenomenon such as it is incomplete to occur carbohydrate metabolism during shortage, and heat energy is under-supply, thus cause hypomnesis, influence the normal function of brain, if vitamin B
1Abundance can effectively form the necessary energy of brain cell activity, but improving memory, concentration power and learning capacity, vitamin B in addition
1Suppress cholinesterase in addition, improve the function of cholinergic nerve; Vitamin B
2Having another name called riboflavin, is the ingredient of many important coenzyme in the body, and it participates in intravital substance metabolism, promotes fetus and baby's growth promoter to play an important role vitamin B to the activity that earns a bare living
2Be to keep skin and the requisite vitamin of eye health, anemia of pregnant woman's vitamin B
2Lack or can not cause or inspire pregnant early pregnancy completely and vomit, second trimester angular cheilitis, glossitis, cheilitis and premature infant's incidence rate increase; Nicotiamide is claimed niacin amide or vitamin PP again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can take place during shortage in synthesizing of assurance gonadal hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes in all kinds of biochemical reaction of catalysis body, all to need pantothenic acid to participate in, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B
6Most important to the maincenter neurodevelopment, if shortage can make the nervus centralis hypoevolutism, intelligence descends, and it has the assistance vitamin B
1Effect, be the vitamin that can improve concentration power and stimulate desire learn; Vitamin B
12Participate in nucleic acid in vivo, choline, amino acid whose metabolism that is synthetic and fatty and sugar; To hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect; It is the necessary vitamin of intelligence of bringing into normal play; Not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid is participated in the synthetic of aminoacid and nucleic acid, and and vitamin B
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at vitamin B in addition
12Under the effect of folic acid as cofactors, by serine of taking in and the synthetic choline of methionine, choline is the key component of acetylcholine, and acetylcholine is a neurotransmitter important in the human body; Folic acid, vitamin B are arranged again
6And vitamin B
12Can work in coordination with and remove the intravital homotype cysteine of people, the homotype cysteine is a kind of neurotoxin, can cause the self murder of brain; There are some researches show that homocysteine is a kind of potential teratogen of independently growing, and is related closely with congenital heart disease and NTD; Homocysteine also can cause miscarriage, premature labor in addition, clinical disastrous effect such as preeclampsia.
Vitamin C is claimed ascorbic acid again.Vitamin C and collagen in close relations; The vessel softening effect is not only arranged, and the effect that purifies the blood in addition prevents arteriosclerosis; Can also promote the absorption of human body to ferrum in the food; For hemopoietic provides essential raw material, simultaneously, vitamin C regain one's strength, aspect effect such as allaying tiredness, keeping tensions down emotion is obvious; Pregnancy duration, subcutaneous hemorrhage can appear in anemia of pregnant woman's hypovitaminosis C or deficiency, swelling and aching of gum, symptom such as bleed, fester, the long-term lacking vitamin C is prone to have virus flu, and increases the danger of fetus teratogenesis, and famine can cause miscarriage.
Vitamin D is the sterols derivant, and the subcutaneous dehydrocholesterol of human body produces vitamin D through ultraviolet radiation
3, ergosterol produces vitamin D behind ultraviolet radiation
2, the two originates different, and function is consistent, and the importance of vitamin D is to regulate the metabolism of calcium and phosphorus in human nutrition; Vitamin D promotes calcium in little intestinal absorption; The then a large amount of calcium of the D that is deficient in vitamin are discharged by feces, thereby cause the human body calcium deficiency, and rickets can take place the child; Become the calcium phosphorus of storing in the human body to exhaust and can cause osteomalacia, modal osteomalacia crowd is anemia of pregnant woman, wet nurse and old people.
Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, and wherein the activity of alpha-tocopherol is the highest.Have the effect of eliminating free radical, slow down aging, prevention maxicell property hemolytic anemia, medically often adopting vitamin E treatment male and female infertility and threatened abortion; Vitamin E deficiency or anemia of pregnant woman's reproductive system is suffered damage, irreversible variation takes place in germinal epithelium, in addition, phenomenons such as maxicell property hemolytic anemia and red blood cell life span shortening can take place also.
Application contains the Rhizoma Atractylodis Macrocephalae and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E has been known as the compositions of active component, but with the Rhizoma Atractylodis Macrocephalae and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, the vitamin E compatibility pharmaceutical composition that is used for prenatal and postnatal care prevention birth defect and improves memory report as yet.
Current medicine that is used to improve memory or health food kind have multiple, but aim at pregnant before the medicine or the health food that are used to improve memory of women, anemia of pregnant woman, wet nurse's development do not see as yet; Do not see the medicine label that is used to prevent birth defect as yet, rarely seen report that folic acid prevention NTD is arranged; But its target spot is few, and the link shortcoming needs perfect.And will prevent the effect of birth defect and improvement memory and be used for same medicine person not see as yet.
Summary of the invention: in order to overcome existing prevention birth defect and/or to improve the shortcoming and defect of remembering medicine; The purpose of this invention is to provide a kind of compositions; Said composition promotes the absorption and the utilization of vitamin through the Rhizoma Atractylodis Macrocephalae, and increases vitamin A, beta-carotene, vitamin B
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E improves the effect of memory and prevention birth defect, simultaneously through vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E, replenish and strengthen the antiabortive and antioxidative effect of Rhizoma Atractylodis Macrocephalae fetus nourishing; Even chronic administration also has no side effect.Because the result of broad research, the inventor have found the Rhizoma Atractylodis Macrocephalae and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E novel combination, this novel combination is for the prevention birth defect and improve memory synergy is arranged; And single with the Rhizoma Atractylodis Macrocephalae and vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E, its effect is all not as good as this compositions; And the effective ingredient of each component has the addition complementary action to the health care tonification of human body, as the Rhizoma Atractylodis Macrocephalae of the used dosage of this compositions have that fetus nourishing is antiabortive, the effect of defying age, enhance immunity, physical strength reinforcing; Vitamin A has the raising vision, prevents the effect of nyctalopia; Vitamin B
1Can prevent and treat vitamin B1 deficiency, keep the normal activity of nerve, digestion, muscle, blood circulation; Vitamin B
2Be to keep skin and the requisite vitamin of eye health; Pellagra can take place in nicotinamide deficiency; The pantothenic acid shortage can cause Metabolic disorder; Biotin can be prevented and treated poliosis, alopecia; Vitamin B
6Can eliminate intraepithelial neoplasia cells, raise immunity, the protection blood vessel; Vitamin B
12Be used for various megaloblastic anemias and neural disease; Folic acid is protected heart and antitumaous effect in addition; Vitamin C has vessel softening, purifies the blood, prevents arteriosclerotic effect; Vitamin E has the free radical of removing, function in delaying senility; The effect of vitamin D protection skeleton.There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides and be used for prenatal and postnatal care prevention birth defect and the compositions of improving memory, it comprises as the Rhizoma Atractylodis Macrocephalae of active component and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E.
The Rhizoma Atractylodis Macrocephalae is the Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala koidz) rhizome.Main product in Zhejiang, ground such as Hubei, Hunan.Gather winter, dries or dry, and life usefulness or parching with earth, parched with bran are used.The Rhizoma Atractylodis Macrocephalae is can be as the natural Chinese medicine of health food, and the used Rhizoma Atractylodis Macrocephalae of the present invention can use its extract as raw material.
Be used for vitamin B of the present invention
1(VitaminB
1), vitamin B
2(VitaminB
2), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B
6(VitaminB
6), vitamin B
12(VitaminB
12), folic acid (FolicAcid), vitamin C (VitaminC), all are water soluble vitamins, do not accumulate in vivo; Vitamin A (Vitamin A), vitamin D (VitaminD), vitamin E (Vitamin E) are fatsoluble vitamiies, and beta-carotene (Beta Carotene) is the precursor substance of vitamin A, and be useful and harmless by the used dosage of the present invention; Professional production factory and supplier are all arranged.
Compositions of the present invention mainly is applicable to women in pregnant early stage, anemia of pregnant woman and wet nurse; Receive the influence of factors such as geology, food chain, dietetic life custom and Time of Administration length, the effective dose that the crowd that benefits from benefits from this compositions each component has certain difference; By the present invention, implemented by weight ratio by following raw materials according: 1, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 500-15000mg/ days with whole crude drug, vitamin B
1Effective dose be 0-20mg/ days, vitamin B
2Effective dose be 0-20mg/ days, the effective dose of nicotiamide is 0-50mg/ days, the effective dose of pantothenic acid is 0-20mg/ days, the effective dose of biotin is 0-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 0-500mg/ days, the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 0-800 μ gRE/ days; The effective dose of vitamin D is 0-0.01mg/ days, and the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 0-150mg α-TE/ days.
2, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 500-15000mg/ days with whole crude drug, vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 0-20mg/ days, the effective dose of biotin is 0-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 0-500mg/ days, the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 0-800 μ gRE/ days; The effective dose of vitamin D is 0-0.01mg/ days, and the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 0-150mg α-TE/ days.
3, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 500-15000mg/ days with whole crude drug, vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 0-20mg/ days, the effective dose of biotin is 0-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 0-800 μ gRE/ days; The effective dose of vitamin D is 0-0.01mg/ days, and the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days.
4, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 500-15000mg/ days with whole crude drug, vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 0-20mg/ days, the effective dose of biotin is 0-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 250-800 μ gRE/ days; The effective dose of vitamin D is 0.0015-0.01mg/ days, and the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days.
5, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 500-15000mg/ days with whole crude drug, vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 250-800 μ gRE/ days; The effective dose of vitamin D is 0.0015-0.01mg/ days, and the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser; For example; Oral formulations (like granule, powder, capsule, ball, sheet, dry syrup, liquid formulation); Or food such as food (like cookies); Mix and prepare with other known additives; This type additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, coating agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. prepare or they are added food as functional component or additive by usual way.
By the present invention, the Rhizoma Atractylodis Macrocephalae, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E each component can distinguish preparation, can the preparation of each component be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this compositions is eliminated the multiple factor that causes birth defect and cause hypomnesis from too many levels, multisystem, many target spots, and the effect of collaborative performance effect is arranged between the each component, to preventing birth defect and improving memory significant effect is arranged; Sufficient raw; Cost is low, and each component has no side effect in the compositions, no incompatibility; Except that prevention birth defect and improvement are remembered, human body still there is the health care benefiting action.
Subordinate list 1 is that this compositions compares with Rhizoma Atractylodis Macrocephalae component and the young rat/mouse labyrinth test effect of vitamin added elements component.
Subordinate list 2 is that this compositions compares with Rhizoma Atractylodis Macrocephalae component and vitamin added elements component Aged Mice maze test effect.
Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.
Embodiment 1:
Rhizoma Atractylodis Macrocephalae 2000mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
With said components further with the additive such as the aluminosilicate magnesium of appropriate amount, gather solvate 60 and propylene glycol mixes equably, with the gained mixture insert capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Rhizoma Atractylodis Macrocephalae 2000mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
With said components further with the additive such as the aluminosilicate magnesium of appropriate amount, gather solvate 60 and propylene glycol mixes equably, with the gained mixture insert capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Rhizoma Atractylodis Macrocephalae 2000mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
With said components further with the additive such as the aluminosilicate magnesium of appropriate amount, gather solvate 60 and propylene glycol mixes equably, with the gained mixture insert capsule equably and 9 capsules, every day 3 times, each 3 capsules
Embodiment 4:
Rhizoma Atractylodis Macrocephalae 2000mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount equably, again the gained mixture is processed 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Embodiment 5:
Rhizoma Atractylodis Macrocephalae 2000mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Pantothenic acid 10mg,
Biotin 0.05mg,
Vitamin C 30mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount equably, again the gained mixture is processed 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.
Subordinate list 1: the young rat/mouse labyrinth test effect of this compositions and Rhizoma Atractylodis Macrocephalae component and vitamin added elements component compares:
Subordinate list 2: this compositions compares with Rhizoma Atractylodis Macrocephalae component and vitamin added elements component Aged Mice maze test effect:
Annotate: each group was tested by dosage feed in the table respectively in 60 days in subordinate list 1, the subordinate list 2; Consumption converts by per kilogram of body weight in the table.
Select 50 of newly-married healthy womens, 25 years old mean age, take this compositions continuously from beginning in pregnant preceding 3 months, followed up a case by regular visits to none routine birth defect in 6 months to the baby due.With the contrast of associated materials statistics, birth defect youngster accounts for the total 4-6% of newborn population, and there were significant differences.
Can obviously find out from table 1, table 2; This compositions is through Rhizoma Atractylodis Macrocephalae component in rat/mouse labyrinth test and the compositions and the contrast of vitamin added elements component; The statistical result of mistake percentage rate, the function of this composition for improved memory is superior to Rhizoma Atractylodis Macrocephalae component or vitamin added elements component; With the blank group significant difference is arranged relatively.
Claims (5)
1. one kind is used for prenatal and postnatal care prevention birth defect and the pharmaceutical composition that improves memory, it is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10-20mg,
Vitamin B
20-20mg,
Nicotiamide 0-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Vitamin A and/or beta-carotene, retinol equivalent 0-800 μ g RE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg α-TE.
2. prenatal and postnatal care prevention birth defect and the pharmaceutical composition that improves memory of being used for according to claim 1 is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Vitamin A and/or beta-carotene, retinol equivalent 0-800 μ g RE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg α-TE.
3. prenatal and postnatal care prevention birth defect and the pharmaceutical composition that improves memory of being used for according to claim 1 is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Vitamin A and/or beta-carotene, retinol equivalent 0-800 μ g RE,
Vitamin D 0-0.01mg,
Vitamin E 5-150mg α-TE.
4. prenatal and postnatal care prevention birth defect and the pharmaceutical composition that improves memory of being used for according to claim 1 is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Vitamin A and/or beta-carotene, retinol equivalent 250-800 μ g RE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg α-TE.
5. prenatal and postnatal care prevention birth defect and the pharmaceutical composition that improves memory of being used for according to claim 1 is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Vitamin A and/or beta-carotene, retinol equivalent 250-800 μ g RE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg α-TE.
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| CN1126078A (en) * | 1994-12-19 | 1996-07-10 | 梁智裕 | Method for prepn. of medical cream for preventing miscarriages, benefitting brain and mental power |
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| CN1126078A (en) * | 1994-12-19 | 1996-07-10 | 梁智裕 | Method for prepn. of medical cream for preventing miscarriages, benefitting brain and mental power |
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