CN101264130B

CN101264130B - Film coating agent for treating skin ulcer

Info

Publication number: CN101264130B
Application number: CN2008100941616A
Authority: CN
Inventors: 乔晋琳
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-05-06
Filing date: 2008-05-06
Publication date: 2011-03-16
Anticipated expiration: 2028-05-06
Also published as: CN101264130A

Abstract

The invention discloses a coating agent treating skin ulcer aiming at solving the problems such as poor antalgic effect and air permeability for prior art. The coating agent treating skin ulcer is produced by following drugs with weight through matching gel-type vehicle with formula dosage according to conventional process: notoginseng 120g, clinopodium herb 120g, asiatic centella 160g, borneo l16g and artificial musk 0.8. The coating agent treating skin ulcer has the advantages of inhibiting platelet aggregation, dilating micro-vessel of partial ulcer, preventing micro thrombus from being formed and antagonizing forming inflammatory mediators, greatly improving partial blood supply of the ulcer, lowering pH value of ulcer surface, promoting acidic environment and facilitating repairing the ulcer and obviously shortening ulcer healing time.

Description

The liniment of treatment skin ulcer

Technical field

The present invention relates to a kind of liniment for the treatment of skin ulcer.

Background technology

(chronic skin ulcer CSU) claims intractable ulcer again, cause of disease complexity to chronic skin ulcer.Commonly encountered diseases is because of comprising: wound, infection, angiopathy, chronic compressing (decubital ulcer), scald etc.And the partial hypoxic-ischemic of the ulcer common Pathophysiology feature that is it.Because of its delay difficult more, easily recurrence and be subjected to clinicist's attention again.Under present condition, adopt more and smear the anti-inflammatory analgetic ointment after the debridement or antiseptic gauze covers the processing of keeping a public place clean.Preceding a kind of method, though can reach the effect of anti-inflammatory analgetic, because the substrate of anti-inflammatory ointment mainly is vaseline, wound surface is airtight behind the smearing ointment, can not absorb wound fluid, therefore is unfavorable for the reparation to wound surface.A kind of method in back, wound surface is ventilated, but easy contaminated wound and do not have the analgesic effect.

Summary of the invention

For overcoming above-mentioned defective, the object of the present invention is to provide the liniment of the preferable treatment skin ulcer of a kind of good analgesic effect, permeability.

For achieving the above object, the liniment of treatment skin ulcer of the present invention, be medicine by following weight be equipped with the recipe quantity gel-type vehicle routinely technology make: Radix Notoginseng 90-130 gram Herba Clinopodii 100-150 gram Herba Centellae 100-200 gram Borneolum Syntheticum 5-20 gram artificial Moschus 0.5-1.2 gram.

Further, above-mentioned medicine is specially: Radix Notoginseng 120 gram Herba Clinopodii 120 gram Herba Centellaes 160 gram Borneolum Syntheticums 16 gram artificial Moschuss 0.8 gram.

Further, above-mentioned gel-type vehicle is to make with polyvinyl alcohol and Sodium Tvlose

Radix Notoginseng sweet and slightly bitter taste in the side, property of medicine tepor is monarch drug, the little bitterness cold of Herba Clinopodii, Herba Centellae bitter in the mouth suffering is cold in nature, is ministerial drug altogether; The Borneolum Syntheticum removing toxic substances and promoting subsidence of swelling, the pain relieving eliminating stagnation, the Moschus understand things pain-stopping, removing toxic substances and promoting subsidence of swelling, with the Borneolum Syntheticum compatibility be adjuvant altogether.Because above-mentioned prescription contains artificial Moschus, Radix Notoginseng, Herba Clinopodii, Herba Centellae and Borneolum Syntheticum, Traditional Chinese medical theory think have heat-clearing and toxic substances removing, the effect of blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.Modern medicine study proves that it mainly has following pharmacological action: the hemostatic compositions arasaponin in (1) Radix Notoginseng has the effect of anticoagulant; (2) artificial Moschus's polypeptide among the artificial Moschus and arasaponin have very strong antiinflammatory action; (3) asiaticoside has the growth and the repair of good promotion skin; (4) Borneolum Syntheticum and artificial Moschus have good analgesic effect; (5) chromocor compound in the Herba Clinopodii has certain removing oxygen-derived free radicals, the effect of anti peroxidation of lipid.Therefore adopt liniment that above-mentioned prescription makes after topical application, have anticoagulant, make the partial Marjoram Extract of ulcer, prevent the formation of microthrombus, the effects such as formation of antagonism inflammatory mediator have been improved the partial blood fortune of ulcer widely.And this product can also reduce the effect of the pH value of ulcer surface, helps the reparation of ulcer to facilitate sour environment; The ulcer healing time is obviously shortened.

The specific embodiment

Below in conjunction with embodiment the present invention is further described.

The liniment of treatment skin ulcer of the present invention, be medicine by following weight be equipped with the recipe quantity gel-type vehicle routinely technology make: Radix Notoginseng 90-130 gram Herba Clinopodii 100-150 gram Herba Centellae 100-200 gram Borneolum Syntheticum 5-20 gram artificial Moschus 0.5-1.2 gram.

Above-mentioned medicine can be in above-mentioned scope proportioning as follows:

Embodiment 1

Radix Notoginseng 100 gram Herba Clinopodii 100 gram Herba Centellaes 100 gram Borneolum Syntheticums 8 gram artificial Moschuss 0.5 gram.

Embodiment 2

Radix Notoginseng 130 gram Herba Clinopodii 140 gram Herba Centellaes 180 gram Borneolum Syntheticums 18 gram artificial Moschuss 1 gram.

Proportioning is best: Radix Notoginseng 120 gram Herba Clinopodii 120 gram Herba Centellaes 160 gram Borneolum Syntheticums 16 gram artificial Moschuss 0.8 gram.

Wherein, above-mentioned gel-type vehicle is with being mainly polyvinyl alcohol, being equipped with Sodium Tvlose again and making.Above-mentioned polyvinyl alcohol can adopt medical polyvinyl alcohol, as polyvinyl alcohol-124.

Method for making: the above-mentioned five tastes, get Radix Notoginseng 120 gram, Herba Clinopodii 120 and Herba Centellae 160 grams and add 6 times of water loggings bubbles after 1 hour, decoct secondary, each 1 hour, be concentrated into every milliliter under the collecting decoction, normal pressure and contain crude drug 1 gram, cold preservation was left standstill 24 hours, filter, clear and bright liquid; It is standby that other gets 30 milliliters of grindings of artificial Moschus's 0.8 gram glycerol adding, and it is standby that Borneolum Syntheticum adds 50 milliliters of dissolvings of ethanol; And above-mentioned three kinds of solution mixings, standby as Chinese medicine extraction liquid.

Take by weighing recipe quantity polyvinyl alcohol-124 and Sodium Tvlose, add suitable quantity of water, put heating in water bath dissolving, swelling is spent the night, and it is fully expanded, and it is standby to be mixed into gel-type vehicle.Above-mentioned Chinese medicine extraction liquid is slowly added in the gel-type vehicle solution, and the limit edged stirs, add potassium sorbate 3 grams and 10 milliliters of dissolvings of the tall and erect ketone of nitrogen after, add second alcohol and water to 1000 milliliter, stir evenly the back packing, cobalt-60 is sterilized, promptly; Finished product is a thick liquid; Gas fragrance is little hot cool.

Certainly, as a kind of distortion of the present invention, also said medicine can be added in the hydrogel matrix, to make hydrogel adhesive.

Function cures mainly: hemostasis by removing blood stasis, heat-clearing and toxic substances removing, subduing swelling and relieving pain.The shallow table open wound that is used for cutter, rifle, all wounds of traumatic injury, firearm injury merges seawater immersion wound, the acute or chronic soft tissue bruise, I degree I I degree and shallow II degree burn, skin ulcer and decubital ulcer, diabetic foot, wound infection, sinus tract, fistula fall cards such as cyanosis of the skin, the blood stasis pouncing on the injury of tendon and muscle and cause do not loose, congestion and swelling pain.

Using method: in wound surface evenly smear this product an amount of after, the aseptic dressing flap coverage is changed dressings 1 every day.

Above-mentioned the effect that prescription has antiinflammatory, regulates immunity, removes free radical, anti peroxidation of lipid can effectively suppress the partial inflammatory reaction of ulcer, reduces cell injury, the granulation wound that protection is newborn.Find topical application debridement breath pain liniment in the clinical observation after 2 weeks, the ulcer surface remarkable improvement, granulation is fresh, and granule is fine and closely woven evenly, the quality softness, blood fortune is good.The ulcer healing time obviously shortens, and tradition is single shifts to an earlier date 12 days with the vaseline group.

Case one:

Wang Yugang, man, 64 years old.No. 17, ZengGuang Road, Haidian District, BeiJing.Suffer from right leg traumatic ulcer April.

Look into: shank outside skin ulcer, be pale pink granulation depression, scope 3.4cm*3.0cm oozes out on a small quantity.Once it is surplus to be coated with February outward with erythromycin ointment, DeGrain.Diagnose through Navy General Hospital: the trauma infection contamination ulcer.The treatment of employing this product, affected part of exterior coating, every day 1 time.After 1 week, the wound surface granulation is scarlet, the uniform particles softness, and secretions obviously reduces, prompting ulcer surface granulation tissue healthy growth.Ulcer healing after 18 days.

Case two:

Shang Xufei, man, 39 years old.No. 273, the exquisite road of Haidian District Beijing.Left upper arm is scalded back skin ulcer March.Look into: left upper arm outside skin ulcer, granulation is pale pink, scope 4.5cm*3.5cm, irregularity boundary has transudate.Once be coated with 1 month with Scald Ointment etc. is outer, ulcer does not close up.Diagnose through Navy General Hospital: skin ulcer after scalding.The treatment of employing this product, affected part of exterior coating, every day 1 time.Ulcer healing after 22 days.

Case three:

Li Xiumei, woman, 74 years old.Fengtai District, Beijing Northeast Railway Bureau craftsman seeks No. 48.Left side sciatic bedsore March.Look into: inside skin ulcer on the left buttocks, scope 3.5cm*3.5cm has transudate.Once used the external application of vaseline emery cloth, ulcer does not close up.Diagnose through Navy General Hospital: decubital ulcer.The treatment of employing this product, affected part of exterior coating, every day 1 time.Ulcer healing after 27 days.

In summary, this product can hemostasis by removing blood stasis, heat-clearing and toxic substances removing; Again can subduing swelling and relieving pain, form protecting film in wound surface, and good permeability, the effect that topical application has antiinflammatory, regulates immunity, removes free radical, anti peroxidation of lipid, can effectively suppress the partial inflammatory reaction of ulcer, reduce cell injury, the granulation wound that protection is newborn; And, show that this dosage form is used for skin safe, effective to studying through the acute toxicity test of skin administration.Therefore adopt this product treatment chronic skin ulcer method simple, evident in efficacy.

Claims

1. liniment for the treatment of skin ulcer, it is characterized in that it be medicine by following weight be equipped with the recipe quantity gel-type vehicle routinely technology make: Radix Notoginseng 90-130 gram Herba Clinopodii 100-150 gram Herba Centellae 100-200 gram Borneolum Syntheticum 5-20 gram artificial Moschus 0.5-1.2 gram.

2. the liniment of treatment skin ulcer as claimed in claim 1 is characterized in that: described medicine is specially: Radix Notoginseng 120 gram Herba Clinopodii 120 gram Herba Centellaes 160 gram Borneolum Syntheticums 16 gram artificial Moschuss 0.8 gram.