CN101254296B

CN101254296B - Pharmaceutical combination with relieving cough, curing asthma and throat-moistening resolve phlegm effect and method of preparing the same

Info

Publication number: CN101254296B
Application number: CN2008100658716A
Authority: CN
Inventors: 不公告发明人
Original assignee: SHENZHEN LIRUI MEDICAL TECHNOLOGY Co Ltd
Current assignee: SHENZHEN LIRUI MEDICAL TECHNOLOGY Co Ltd
Priority date: 2008-03-25
Filing date: 2008-03-25
Publication date: 2011-06-22
Anticipated expiration: 2028-03-25
Also published as: CN101254296A; WO2009117952A1

Abstract

The invention discloses a pharmaceutical composition with the effects of relieving cough, calming asthma, moistening throat and resolving phlegm, which belongs to the traditional Chinese medicine field. The pharmaceutical raw materials of the pharmaceutical composition are 3 to 15 parts of Chinese magnoliavine fruit or 3 to 15 parts of dark plum fruit, 1 to 6 parts of ginger and 1 to 10 parts of manchurian wildginger, and the pharmaceutical composition can be prepared into any common preparation form for internal use. The different ministerial drugs or adjuvant drugs can be added according to the different symptoms and traditional Chinese medicine mechanisms. With the effects of warming lung, benefiting qi, astringing lung, purging lung, lowing lung-qi, eliminating pathogen and resolving phlegm and so on and the significant functions of stopping cough, calming asthma, moistening throat and resolving phlegm, the pharmaceutical composition of the invention can be used for the treatment of four-season cough, throat itching, throat pain, phlegm or no phlegm.

Description

A kind ofly have cough-relieving, relieving asthma, the pharmaceutical composition of throat-moistening resolve phlegm effect and preparation method thereof

[technical field]

The present invention relates to a kind ofly have cough-relieving, relieving asthma, the pharmaceutical composition of throat-moistening resolve phlegm effect and preparation method thereof, belong to the field of Chinese medicines.

[technical background]

Cough, asthma is a class common disease, has the chemicals of antitussive action to contain the anesthesia composition mostly at present, and life-time service tolerates easily, and curative effect reduces, even causes serious problems such as drug dependence; Present widely used anti-asthmatic mostly can only the respite symptom, and curative effect can not be lasting, and causes cardiopalmus, untoward reaction such as uncomfortable in chest easily; The effective percentage of the numerous Chinese patent medicine of Xiao Shouing is all not high in the market, mostly only can the respite throat itch pain, cough symptom, or reach and reduce phlegm or the purpose of eliminating the phlegm, seldom can thoroughly cure.To some for a long time or repeatedly cough, the asthma patient of outbreak, lack the medicine of determined curative effect at present especially.Medicine of the present invention be a kind ofly have remarkable cough-relieving, relieving asthma, the medicine of throat-moistening resolve phlegm effect, can rapidly, efficiently alleviate or control fully throat itch pain, four seasons cough, asthma, expectorant is arranged or does not have symptom such as expectorant; Simultaneously, with the variation of compatibility of drugs, can be to cough, the asthma performance better therapeutic of different traditional Chinese medical science accompanied symptoms.

[summary of the invention]

The object of the present invention is to provide a kind ofly have cough-relieving, relieving asthma, the pharmaceutical composition of throat-moistening resolve phlegm effect.

The crude drug of this pharmaceutical composition is: Fructus Schisandrae Chinensis 3-15 weight portion, Rhizoma Zingiberis Recens 1-6 weight portion, Herba Asari 1-10 weight portion, wherein available Fructus Mume 3-15 weight portion replace Fructus Schisandrae Chinensis 3-15 weight portion (hereinafter this 3 compositions of distinguishing the flavor of crude drug to be called " A "; The consumption of all crude drug all refers to weight portion).

Be preferably: 6 parts of 6 parts of Fructus Schisandrae Chinensis or Fructus Mumes, 3 parts of Rhizoma Zingiberis Recens, 6 parts of Herba Asaris.

The present invention also provides this kind preparation of drug combination method, wherein:

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, when Herba Asari is crude drug, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, standby.

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, and the Rhizoma Zingiberis Recens of residue and described weight proportion adds 8～15 times of water gagings and decocts 1～3 time, each 1～3 hour, filters, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 2.

3) Fructus Schisandrae Chinensis of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3.

4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention.

Perhaps

When Fructus Mume, Rhizoma Zingiberis Recens, when Herba Asari is crude drug, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, standby.

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, and the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filters, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 2.

3) pulverize component 2, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention.

The present invention provides also that aforementioned pharmaceutical compositions has cough-relieving in preparation, relievings asthma, the purposes in the medicine of throat-moistening resolve phlegm effect.

On the other hand, the invention provides a kind ofly have cough-relieving, relieving asthma, the pharmaceutical composition of throat-moistening resolve phlegm effect, it is a monarch drug with the three flavor crude drug of A, also adds Cortex Mori 6-40 part or Cortex Lycii 6-40 part (hereinafter the pharmaceutical composition with this 4 flavor crude drug is called " B ") as adjuvant drug.

Be preferably: 25 parts of 6 parts of 6 parts of Fructus Schisandrae Chinensis or Fructus Mumes, 3 parts of Rhizoma Zingiberis Recens, 6 parts of Herba Asaris, 25 parts of Cortex Mori or Cortex Lycii.

The present invention also provides the preparation of drug combination method of B, wherein:

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, when Herba Asari is monarch drug, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, standby.

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, the Rhizoma Zingiberis Recens of residue and described weight proportion, Cortex Mori or Cortex Lycii add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 2.

When Fructus Mume, Rhizoma Zingiberis Recens, when Herba Asari is monarch drug, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, standby.

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 2.

3) component 2 is pulverized, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention.

The present invention also provides another kind of and has had cough-relieving, relievingd asthma, the pharmaceutical composition of throat-moistening resolve phlegm effect, and it also adds Herba Menthae 3-9 part or Periostracum Cicadae 3-9 part (hereinafter this 5 pharmaceutical compositions of distinguishing the flavor of crude drug being called " C ") as adjuvant drug based on B.

Be preferably: 6 parts of 6 parts of 6 parts of Fructus Schisandrae Chinensis or Fructus Mumes, 3 parts of Rhizoma Zingiberis Recens, 6 parts of Herba Asaris, 25 parts of Cortex Mori or 25 parts of Cortex Lycii, 6 parts of Herba Menthaes or Periostracum Cicadaes.

The present invention also provides the preparation of drug combination method of C, wherein:

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Herba Menthae, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Menthae, standby.

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2.Medicinal liquid after distillation device is in addition collected, the Rhizoma Zingiberis Recens of residue and described weight proportion, Cortex Mori or Cortex Lycii add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 3.

3) Fructus Schisandrae Chinensis of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 4.

4) merge component 3 and component 4, pulverize, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention.

Perhaps

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; In Rhizoma Euonymus or the Cortex Lycii one when being adjuvant drug with Periostracum Cicadae, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Periostracum Cicadae, standby.

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, the Rhizoma Zingiberis Recens of residue and described weight proportion, Cortex Mori or Cortex Lycii, Periostracum Cicadae add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 2.

Perhaps

When Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Herba Menthae, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Menthae, standby.

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2.Medicinal liquid after distillation device is in addition collected, the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 3.

3) component 3 is pulverized, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention.

Perhaps

When Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Periostracum Cicadae, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Periostracum Cicadae, standby.

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 2.

The present invention also provides another kind of and has had cough-relieving, relievingd asthma, the pharmaceutical composition of throat-moistening resolve phlegm effect, and it also adds Rhizoma Pinelliae 5-20 part or Poria 5-30 part (hereinafter this 6 pharmaceutical compositions of distinguishing the flavor of crude drug being called " D ") as ministerial drug based on C.

Be preferably: 6 parts of 6 parts of 6 parts of Fructus Schisandrae Chinensis or Fructus Mumes, 3 parts of Rhizoma Zingiberis Recens, 6 parts of Herba Asaris, 12 parts of the Rhizoma Pinelliaes or 20 parts in Poria, 25 parts of Cortex Mori or 25 parts of Cortex Lycii, 6 parts of Herba Menthaes or Periostracum Cicadaes.

The present invention also provides the preparation of drug combination method of D, wherein:

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; The Rhizoma Pinelliae is a ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Herba Menthae, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, the Rhizoma Pinelliae, Cortex Mori or Cortex Lycii, Herba Menthae, standby.

3) Fructus Schisandrae Chinensis, the Rhizoma Pinelliae of described weight proportion are measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 4.

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; The Rhizoma Pinelliae is a ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Periostracum Cicadae, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, the Rhizoma Pinelliae, Cortex Mori or Cortex Lycii, Periostracum Cicadae, standby.

3) Fructus Schisandrae Chinensis, the Rhizoma Pinelliae of described weight proportion are measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3.

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Poria is a ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Herba Menthae, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Poria, Herba Menthae, standby.

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2.Medicinal liquid after distillation device is in addition collected, the Rhizoma Zingiberis Recens of residue and described weight proportion, Cortex Mori or Cortex Lycii, Poria add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 3.

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Poria is a ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Periostracum Cicadae, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Poria, Periostracum Cicadae, standby.

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, the Rhizoma Zingiberis Recens of residue and described weight proportion, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Poria add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 2.

When Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; The Rhizoma Pinelliae is a ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Herba Menthae, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, the Rhizoma Pinelliae, Herba Menthae, standby.

3) Rhizoma Pinelliae of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 4.

When Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; The Rhizoma Pinelliae is a ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Periostracum Cicadae, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, the Rhizoma Pinelliae, Periostracum Cicadae, standby.

3) Rhizoma Pinelliae of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3.

When Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Poria is a ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Herba Menthae, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Poria, Herba Menthae, standby.

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2.Medicinal liquid after distillation device is in addition collected, the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Poria add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 3.

When Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Poria is a ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Periostracum Cicadae, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Poria, Periostracum Cicadae, standby.

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Poria add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 2.

The present invention also provides another kind of and has had cough-relieving, relievingd asthma, the pharmaceutical composition of throat-moistening resolve phlegm effect, and it also adds Herba Ephedrae 3-15 part, Semen Armeniacae Amarum 3-15 part (hereinafter this 7 pharmaceutical compositions of distinguishing the flavor of crude drug being called " E ") as ministerial drug based on C

Be preferably: 6 parts of 6 parts of 6 parts of Fructus Schisandrae Chinensis or Fructus Mumes, 3 parts of Rhizoma Zingiberis Recens, 6 parts of Herba Asaris, 25 parts of Cortex Mori or 25 parts of Cortex Lycii, 9 parts in Herba Ephedrae, 9 parts in Semen Armeniacae Amarum, 6 parts of Herba Menthaes or Periostracum Cicadaes.

The present invention also provides the preparation of drug combination method of E, wherein:

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Herba Ephedrae, Semen Armeniacae Amarum are ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Herba Menthae, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Herba Menthae, standby.

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2.Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Herba Ephedrae, the Semen Armeniacae Amarum of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 3.

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Herba Ephedrae, Semen Armeniacae Amarum are ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Periostracum Cicadae, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Periostracum Cicadae, standby.

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, the Semen Armeniacae Amarum of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 2.

When Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Herba Ephedrae, Semen Armeniacae Amarum are ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Herba Menthae, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Herba Menthae, standby.

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2.Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Fructus Mume, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Herba Ephedrae, the Semen Armeniacae Amarum of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 3.

When Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Herba Ephedrae, Semen Armeniacae Amarum are ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Periostracum Cicadae, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Periostracum Cicadae, standby.

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Fructus Mume, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, the Semen Armeniacae Amarum of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 2.

The present invention also provides another kind of and has had a cough-relieving, relievingd asthma, the pharmaceutical composition of throat-moistening resolve phlegm effect, it is based on C, also adds as Rhizoma Pinelliae 5-20 part of ministerial drug or Poria 5-30 part, Herba Ephedrae 3-15 part, Semen Armeniacae Amarum 3-15 part (hereinafter the pharmaceutical compositions with this 8 flavor crude drug are called " F ").

Be preferably: 6 parts of 6 parts of 6 parts of Fructus Schisandrae Chinensis or Fructus Mumes, 3 parts of Rhizoma Zingiberis Recens, 6 parts of Herba Asaris, 25 parts of Cortex Mori or 25 parts of Cortex Lycii, 12 parts of the Rhizoma Pinelliaes or 20 parts in Poria, 9 parts in Herba Ephedrae, 9 parts in Semen Armeniacae Amarum, 6 parts of Herba Menthaes or Periostracum Cicadaes.

The present invention also provides the preparation of drug combination method of F, wherein:

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae are ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Herba Menthae, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Herba Menthae, standby.

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae are ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Periostracum Cicadae, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Periostracum Cicadae, standby.

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Herba Ephedrae, Semen Armeniacae Amarum, Poria are ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Herba Menthae, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Poria, Herba Menthae, standby.

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2.Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, the Poria of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 3.

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Herba Ephedrae, Semen Armeniacae Amarum, Poria are ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Periostracum Cicadae, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Poria, Periostracum Cicadae, standby.

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum, the Poria of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 2.

When Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae are ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Herba Menthae, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Herba Menthae, standby.

When Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae are ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Periostracum Cicadae, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Periostracum Cicadae, standby.

When Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Herba Ephedrae, Semen Armeniacae Amarum, Poria are ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Herba Menthae, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Poria, Herba Menthae, standby.

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2.Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Fructus Mume, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, the Poria of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 3.

When Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari are monarch drug; Herba Ephedrae, Semen Armeniacae Amarum, Poria are ministerial drug; In Cortex Mori or the Cortex Lycii one when being adjuvant drug with Periostracum Cicadae, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Poria, Periostracum Cicadae, standby.

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Fructus Mume, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum, the Poria of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 2.

At last, the invention provides above-mentioned A, B, C, D, E and six kinds of pharmaceutical compositions of F and have cough-relieving, relieving asthma in preparation, the purposes in the medicine of throat-moistening resolve phlegm effect.

The medical material that the present invention uses is:

Fructus Schisandrae Chinensis of the present invention is the dry mature fruit of Schisandra chinensis (Turcz.) Baill..

Fructus Mume of the present invention is the dry almost ripe fruit of rose department plant plum Prunus mume (Sibe.) Sieb.et Zucc..

Rhizoma Zingiberis Recens of the present invention is fresh or dry rhizome and the processed product thereof of Zingiber officinale Rosc..

Herba Asari of the present invention is the root and rhizome of aristolochiaceae plant Herba Asari Asarum heterotropoides Fr.Schmidt var.mandshuricum (Maxim.) Kitag. Seoul Herba Asari Asarum sieboldii Miq.var.seoulense Nakai or magnificent Herba Asari Asarum sieboldii Miq..

Cortex Mori of the present invention is the dry root bark of moraceae plants Mulberry Morus alba L..

Cortex Lycii of the present invention is the dry root bark of matrimony vine of solanaceae plant Lycium chinense Mill. or lycium barbarum Lycium barbarumL..

Herba Menthae of the present invention is the dry aerial parts of labiate Herba Menthae Mentha haplocalyx Briq..

Periostracum Cicadae of the present invention is the nymph of cicada Cryptotympana atrata Fabr. Cryptotympana pustulata Fabricius exuviae shell when sprouting wings.

The Rhizoma Pinelliae of the present invention is the dry tuber of aroid Rhizoma Pinelliae Pinellia ternate (Thunb.) Breit. and concocts processed goods.

Poria of the present invention is the dry sclerotia of Poria coco (Schw.) Wolf.

Herba Ephedrae of the present invention is the dry herb stem of Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf., epheday intermedia Ephedra intermediaSchrenk et C.A.Mey. or ephedra equisetina Ephedra equisetina Bge., and processed product, comprise Herba Ephedrae and Herba Ephedrae (processed).

Semen Armeniacae Amarum of the present invention is the dry mature seed of rosaceous plant Prunus armeniaca L.var.ansu Maxim. Prunus armeniaca L.var.ansu Maxim., Siberia Fructus Pruni Prunus sibirica L., prunus mandshuricaKoehne Prunus mandshurica (Maxim.) Koehne or Fructus Pruni Prunus armeniaca L..

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.For example these raw medicinal material pulverize mix homogeneously can be made powder takes after mixing it with water; Can also these raw medicinal materials can be utilized modern technologies to extract these raw medicinal materials decocting together or ethanol extraction, as passing through supercritical carbon dioxide (SFE-CO ₂) extraction or ultrasonic extraction etc., concentrate drying then.But for each crude drug that makes this medicine is brought into play drug effect better, preferably the Fructus Schisandrae Chinensis in all medical materials, the Rhizoma Pinelliae are carried out ethanol extraction, Fructus Mume in all medical materials, Rhizoma Zingiberis Recens, Cortex Mori, Cortex Lycii, Periostracum Cicadae, Poria, Herba Ephedrae, Semen Armeniacae Amarum are carried out decocting, the Herba Asari in all medical materials, Herba Menthae are carried out vapor distillation.

Needed various conventional adjuvants when active ingredient in pharmaceutical of the present invention can add the preparation different dosage form, method of Chinese medicinal as routines such as disintegrating agent, lubricant, binding agent, correctivess is prepared into any dosage form for oral administration commonly used, as granule, electuary, tablet, drop pill, pill, capsule, soft capsule, oral liquid, mixture etc.

Medicine of the present invention has cough-relieving, relievings asthma, the pharmaceutical composition of throat-moistening resolve phlegm effect, can be used for treating cough, the asthma of various acute and chronic or repeated relapsings, or with respiratory system diseases such as the acute and chronic pharyngolaryngitis of itching throat, cough, symptoms of asthma, asthma, bronchitis, emphysema, pulmonary heart diseases.

[novelty of invention]

The clinical manifestation of cough, asthma is very complicated, changeable, and clinician and patient usually are difficult to differentiate and hold, and Chinese patent medicine on the market is mostly owing to lack clear and definite indication or use pointer and can not obtain clinical efficacy reliably at present.The inventor the traditional Chinese medical science face be surprised to find that in the card process have warming the lung, the Fructus Schisandrae Chinensis (or Fructus Mume) of the evil function of loosing, Rhizoma Zingiberis Recens, Herba Asari 3 flavor raw medicinal materials combinations all have reliable curative effect to majority cough, asthma patient (comprise chronic cough, roar for a long time or breathe heavily for a long time), the combination of this 3 flavor crude drug has obtained unexpected synergism, and by a series of zooperies and clinical practice proof 3 flavor crude drug not only simply but also can bring into play good effect, be the core of pharmaceutical composition of the present invention; Wherein Fructus Mume and Fructus Schisandrae Chinensis are interchangeable, and they serve the same role in this compositions, and those skilled in the art should approve that this exchange does not influence the effect and the unicity of pharmaceutical composition of the present invention.Secondly, the inventor further studies on this basis, if find to add Cortex Mori with eliminating heat from the lung, relieving cough and asthma function or Cortex Lycii as using corrigent, clinical efficacy can be better.In addition, the inventor also recognizes, if add Herba Menthae with evil, the sore-throat relieving function of loosing or the Periostracum Cicadae supplementary drug as monarch drug, curative effect can further improve.Because cough, the pathogenesis of asthma patient and clinical manifestation are very complicated, so should add different ministerial drugs according to different accompanied symptoms, as a surname of lung obviously imbalance person of function falls, when the genus with Herba Ephedrae, Semen Armeniacae Amarum is a ministerial drug; The accumulation of phlegm-damp in the lung person should remove its phlegm-damp with product such as Poria, the Rhizoma Pinelliaes; These accompanied symptoms can one card solely see, also can two cards or demonstrate,prove concurrently more, so drug regimen and dosage also change thereupon.But these all can not break away from the compatibility of medicine monarch drug of the present invention and adjuvant drug (comprising corrigent, supplementary drug) with the card plus-minus.

With regard to certain fixed drug compositions, different doctors have different sides and separate, this be because of the doctor Thinking Difference, this pharmaceutical composition at the disease or the multiformity decision of conditions of patients, but these can not influence the beneficial effect of this pharmaceutical composition.So long as the compositions that is made of these crude drug all falls within the scope of the present invention, no matter and different doctors to the distribution of monarch.The monarch that the inventor describes is just represented the inventor's prescription thinking, and is not intended to protection domain is made qualification.For example, among the present invention, different doctors can think that also the pathogenesis of cough, asthma is: functional disorder falls in a surname of lung, so Herba Ephedrae, Semen Armeniacae Amarum are interpreted as monarch drug, Fructus Schisandrae Chinensis or Fructus Mume, Rhizoma Zingiberis, Herba Asari etc. are interpreted as ministerial drug, but, just can not influence the realization of its beneficial effect if do not change the composition of pharmaceutical composition crude drug of the present invention.

People have extracted from Herba Menthae and have mainly contained effective substance Oleum menthae or Mentholum, and are widely used in food such as antitussive or larynx moistening candy or the health food, so the Herba Menthae in the combination of above-mentioned raw materials medicine also can replace with Oleum menthae or Mentholum.The traditional Chinese medical science is recognized for a long time, Radix Glycyrrhizae (root and the root stock of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat., Glycyrrhiza glabra L. Glycyrrhiza glabra L.) has the effect of coordinating the actions of various ingredients in a prescription, so, arbitrary material medicine combination of the present invention all can add Radix Glycyrrhizae 3-30 weight portion (preferred 6 weight portions), but it can't obviously influence the beneficial effect of pharmaceutical composition of the present invention.

[specific embodiment]

Pharmacological evaluation:

Below further set forth the beneficial effect of pharmaceutical composition of the present invention by testing example.

1 material

1.1 animal

SPF level kunming mouse, male and female half and half, body constitution amount (20 ± 2) g; Healthy guinea pig, male and female half and half, the scale of construction 200～250g; Raise room temperature (22 ± 2) ℃, normally raise behind the 3d for examination.

1.2 instrument

722 type spectrophotometers, Shanghai the 3rd analytical tool factory produces.Ultrasound atomizer CSW-1 type, Shantou, Guangdong photoelectricity medical apparatus and instruments factory produces.

1.3 medicine and reagent

Pharmaceutical composition N1-N54 of the present invention (the crude drug kind of each pharmaceutical composition is seen note, and the consumption of each crude drug is referring to the preferable amount of each crude drug that provides in the summary of the invention) is made into desired concn with distilled water during use; Codeine phosphate, Qinghai Pharmaceutic Plant produces (commercial); Ammonium chloride, Zhuzhou City, Hunan chemical reagent three factory's products (commercial); Aminophylline, Hunan pharmaceutical factory produces (commercial).Phenol red, chemical reagent three factories in Shanghai produce (commercial); Histamine, the beautiful pearl east wind in Shanghai Bioisystech Co., Ltd's product (commercial); Acecoline, Shanghai chemistry examination thorn three factory's products (commercial).

2 methods and result

2.1 statistical method

Adopt the SPSS10.0 statistical software to carry out statistical procedures.Statistical method measurement data One-way-ANOVA compares between many groups in twos, with LSD (Least-Signficant-Difference) statistics, and enumeration data Pearson Chi-square statistics.

2.2 ammonia brings out the influence of mouse cough model

Kunming mouse, ♀ ♂ half and half is divided into 60 groups at random, 10 every group, is respectively blank group, Fructus Schisandrae Chinensis group, Rhizoma Zingiberis Recens group, Herba Asari group, Fructus Mume group and is subjected to reagent N1-N54 group, positive controls (codeine phosphate group).Each organizes administration 1.67g crude drug/Kg body weight (clinical equivalent dosage), gastric infusion 3d, after the last administration 1 hour, respectively mice is put into ultrasound atomizer, accept spraying (ammonia concn is 25%), behind the 30s, observe the cough number of times that cough is hidden and 3min is interior of mice, compare each administration group and normal control group difference situation respectively.The results are shown in Table 1.

Table 1 pharmaceutical composition brings out the influence (x ± s) of mouse cough model to ammonia

Annotate: with the contrast of blank group, * P＜0.05, * * P＜0.01, * * * P＜0.001

▲: curative effect is better than N1-N2;

△: curative effect is better than N3-N6;

★: curative effect is better than N7-N14.

2.3 influence to the phenol red excretion amount of mice trachea section

Kunming mouse, ♀ ♂ half and half is divided into 60 groups at random, 10 every group, be respectively the blank group,, Fructus Schisandrae Chinensis group, Rhizoma Zingiberis Recens group, Herba Asari group, Fructus Mume group and N1-N54 group, positive controls (ammonium chloride group).Each organizes administration 1.67g crude drug/Kg body weight (clinical equivalent dosage), gastric infusion 3d, 1 hour phenol red (0.1mL/ (5mg)/10g) of pneumoretroperitoneum injection of last administration, put to death mice behind the 30min, peel off the trachea surrounding tissue, cut one section trachea down to the trachea bifurcation from thyroid cartilage, put in the test tube that fills the 2mL normal saline, the NaOH 0.1mL that adds 1mol/L again, reuse 722 type spectrophotometers (wavelength is 546 μ m) are surveyed the OD value, compare the difference condition between each administration group and normal control group respectively, the results are shown in Table 2.

Table 2 pharmaceutical composition is to the influence of the phenol red excretion amount of mice trachea section (X ± S)

▲: curative effect is better than N1-N2;

△: curative effect is better than N3-N6;

★: curative effect is better than N7-N14.

2.4 influence to the effect of Cavia porcellus experimental asthma

Select body weight 200～250g healthy guinea pig for use, male and female half and half, place respectively in the volumetrical airtight clear glass bell jar of 4L, continue to spray into 0.1% histamine and 20 seconds of 2% acecoline equivalent mixed liquor with the ultrasound atomizer constant voltage, (beginning dyspnea to occur to asthma attack from spraying, until the time that tic is fallen) breathed heavily incubation period in drawing of observed and recorded Cavia porcellus, if surpass 150 seconds nonresponders, will not select for use.Get 560 of the qualified Cavia porcelluss of screening, be divided into 60 groups at random: blank group, aminophylline group, Fructus Schisandrae Chinensis group, Rhizoma Zingiberis Recens group, Herba Asari group, Fructus Mume group and organized by reagent N1-N54.Test every group of each gastric infusion 1 time in the preceding 2 day morning (except the aminophylline group), dosage is 1.366g crude drug/Kg body weight, behind the experiment that morning administration 1h, Cavia porcellus is put in people's glass bell jar, measures drawing of Cavia porcellus by preselected conditions and method and breathes heavily incubation period.If surpass the 6min person of still asthma reaction not thing take place, press 360s calculating its incubation period.The results are shown in Table 3.

Table 3 pharmaceutical composition is to the influence of Cavia porcellus experimental asthma effect (X ± S)

Group N dosage (g/kg) asthma incubation period (s)

Blank group 10 50.73 ± 12.31

Fructus Schisandrae Chinensis group 10 1.336 52.24 ± 10.3

Rhizoma Zingiberis Recens organizes 10 1.336 49.11 ± 11.42

Herba Asari group 10 1.336 51.57 ± 8.11

Fructus Mume group 10 1.336 52.11 ± 12.33

Aminophylline group 10 0.125 156.54 ± 16.75***

N1 10 1.336 62.48±9.21*

N2 10 1.336 64.36±6.14*

N3 10 1.336 72.69±10.44*▲

N4 10 1.336 74.71±14.08*▲

N5 10 1.336 73.41±6.50*▲

N6 10 1.336 74.15±5.11*▲

N7 10 1.336 80.25±11.07*△

N8 10 1.336 78.43±9.91*△

N9 10 1.336 80.31±6.14*△

N10 10 1.336 82.54±4.44*△

N11 10 1.336 82.42±6.19*△

N12 10 1.336 80.50±13.44*△

N13 10 1.336 81.36±8.14*△

N14 10 1.336 79.14±10.52*△

N15 10 1.336 95.51±12.17**★

N16 10 1.336 90.24±11.07**★

N17 10 1.336 95.62±10.67**★

N18 10 1.336 94.36±5.14**★

N19 10 1.336 96.66±14.71**★

N20 10 1.336 92.48±10.28**★

N21 10 1.336 96.68±7.15**★

N22 10 1.336 99.84±10.23**★

N23 10 1.336 91.22±17.21**★

N24 10 1.336 89.43±12.44**★

N25 10 1.336 92.45±7.24**★

N26 10 1.336 94.35±12.36**★

N27 10 1.336 92.48±16.99**★

N28 10 1.336 95.51±7.17**★

N29 10 1.336 95.36±7.25**★

N30 10 1.336 94.63±4.21**★

N31 10 1.336 99.47±6.47**★

N32 10 1.336 96.47±5.14**★

N33 10 1.336 95.33±8.61**★

N34 10 1.336 97.06±3.19**★

N35 10 1.336 98.31±4.02**★

N36 10 1.336 96.25±3.61**★

N37 10 1.336 97.65±8.14**★

N38 10 1.336 94.10±7.45**★

N39 10 1.336 95.37±17.21**★

N40 10 1.336 92.12±12.44**★

N41 10 1.336 98.40±8.34**★

N42 10 1.336 96.01±10.06**★

N43 10 1.336 92.48±11.01**★

N44 10 1.336 96.43±6.24**★

N45 10 1.336 95.18±5.45**★

N46 10 1.336 92.63±7.63**★

N47 10 1.336 94.55±3.85**★

N48 10 1.336 98.29±5.76**★

N49 10 1.336 95.61±3.62**★

N50 10 1.336 98.16±10.09**★

N51 10 1.336 93.69±4.88**★

N52 10 1.336 96.73±13.27**★

N53 10 1.336 97.06±8.28**★

N54 10 1.336 94.93±7.53**★

▲: curative effect is better than N1-N2;

△: curative effect is better than N3-N6;

★: curative effect is better than N7-N14.

3 discuss

Pharmaceutical composition N1 to N54 of the present invention all can suppress strong aqua ammonia spraying the causing cough of mice, prolong cough latent period, reduce the cough number of times, prompting has tangible antitussive action, and can significantly improve the phenol red secretion of mice trachea, promote the respiratory mucosa glandular secretion, thereby make the sputum dilution reach the expectorant effect; Cavia porcellus asthma is respectively organized in medication in addition all has obvious prolongation incubation period, shows that respectively organizing medication all has significant antiasthmatic effect to whole Cavia porcellus experimental asthma.Experimental result has proved that also the combination of the three flavor medical materials of N1, N2 has produced extra synergism than the simple combination of single medical material, and, the synergism that is obtained between N1 and the N2 is basic identical, proved to be based between N1 and the N2 that identical prescription thinking obtains, and be better than the simple combination of three kinds of medical materials.In addition, on the basis of three flavor medical materials, the ministerial drug, adjuvant drug etc. that have increased other all can make drug effect further be brought into play.Experiment shows that also the effect of N3 to N6 is better than N1 and N2, and the effect of N7 to N14 is better than N3 to N6, and the effect of N15 to N54 is better than N1 to N14 again simultaneously.

Note: the crude drug combination of pharmaceutical composition N1-N54 of the present invention sees the following form:

The pharmaceutical composition numbering	The crude drug combination
		N1	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari
N2	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari
		N3	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Mori
N4	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Lycii
		N5	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Mori
N6	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Lycii
		N7	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Mori, Herba Menthae
N8	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Lycii, Herba Menthae

N9	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Mori, Herba Menthae
		N10	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Lycii, Herba Menthae

N11	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Mori, Periostracum Cicadae
		N12	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Lycii, Periostracum Cicadae
N13	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Mori, Periostracum Cicadae
		N14	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Lycii, Periostracum Cicadae
N15	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Mori, Herba Menthae, Herba Ephedrae, Semen Armeniacae Amarum
		N16	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Lycii, Herba Menthae, Herba Ephedrae, Semen Armeniacae Amarum
N17	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Mori, Herba Menthae, Herba Ephedrae, Semen Armeniacae Amarum
		N18	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Lycii, Herba Menthae, Herba Ephedrae, Semen Armeniacae Amarum
N19	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Mori, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum
		N20	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum
N21	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Mori, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum
		N22	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum
N23	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Mori, Herba Menthae, the Rhizoma Pinelliae
		N24	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Lycii, Herba Menthae, the Rhizoma Pinelliae
N25	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Mori, Herba Menthae, the Rhizoma Pinelliae
		N26	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Lycii, Herba Menthae, the Rhizoma Pinelliae
N27	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Mori, Periostracum Cicadae, the Rhizoma Pinelliae
		N28	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Lycii, Periostracum Cicadae, the Rhizoma Pinelliae
N29	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Mori, Periostracum Cicadae, the Rhizoma Pinelliae
		N30	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Lycii, Periostracum Cicadae, the Rhizoma Pinelliae
N31	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Mori, Herba Menthae, Poria
		N32	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Lycii, Herba Menthae, Poria
N33	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Mori, Herba Menthae, Poria

N34	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Lycii, Herba Menthae, Poria
		N35	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Mori, Periostracum Cicadae, Poria
N36	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Lycii, Periostracum Cicadae, Poria
		N37	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Mori, Periostracum Cicadae, Poria
N38	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Lycii, Periostracum Cicadae, Poria

N39	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Mori, Herba Menthae, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae
		N40	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Lycii, Herba Menthae, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae
N41	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Mori, Herba Menthae, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae
		N42	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Lycii, Herba Menthae, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae
N43	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Mori, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae
		N44	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae
N45	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Mori, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae
		N46	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae
N47	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Mori, Herba Menthae, Herba Ephedrae, Semen Armeniacae Amarum, Poria
		N48	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Lycii, Herba Menthae, Herba Ephedrae, Semen Armeniacae Amarum, Poria
N49	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Mori, Herba Menthae, Herba Ephedrae, Semen Armeniacae Amarum, Poria
		N50	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Lycii, Herba Menthae, Herba Ephedrae, Semen Armeniacae Amarum, Poria
N51	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Mori, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum, Poria
		N52	Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Asari, Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum, Poria
N53	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Mori, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum, Poria
		N54	Rhizoma Zingiberis Recens, Fructus Mume, Herba Asari, Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum, Poria

Preparation method:

Below enumerated the multiple method for preparing pharmaceutical composition of the present invention, but these methods only are illustrative, but not are intended to scope of the present invention is made restriction.

The oral liquid preparation of [embodiment 1] pharmaceutical composition of the present invention

1) take by weighing each crude drug Fructus Schisandrae Chinensis 6g, Rhizoma Zingiberis Recens 3g, Herba Asari 6g, standby.

2) Herba Asari is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, and residue and Rhizoma Zingiberis Recens add 10 times of water gagings and decoct each 1 hour 3 times, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), add 70% ethanol precipitate with ethanol, get the supernatant decompression recycling ethanol, it is an amount of to add water, stirs evenly, and leaves standstill, filter, get component 2.

3) Fructus Schisandrae Chinensis that is ground into coarse powder of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, it is an amount of to add water, stirs evenly, and leaves standstill, and filters, and gets component 3.4) merge component 1, component 2 and component 3, mixing, promptly.

The oral liquid preparation of [embodiment 2] pharmaceutical composition of the present invention

1) take by weighing each crude drug Fructus Mume 6g, Rhizoma Zingiberis Recens 3g, Herba Asari 6g, standby.

2) Herba Asari is collected distillate with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, and residue and Fructus Mume, Rhizoma Zingiberis Recens add 10 times of water gagings and decoct each 1 hour 3 times, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), add 70% ethanol precipitate with ethanol, get the supernatant decompression recycling ethanol, it is an amount of to add water, stirs evenly, and leaves standstill, filter, get component 2.

3) merge component 1 and component 2, mixing, promptly.

The preparation of the tablet of [embodiment 3] pharmaceutical composition of the present invention

1) take by weighing each crude drug Fructus Schisandrae Chinensis 6g, Rhizoma Zingiberis Recens 3g, Herba Asari 6g, Cortex Mori 25g, Herba Menthae 6g, Rhizoma Pinelliae 12g or Poria 20g, standby.

2) Herba Asari, Herba Menthae are collected distillate with steam distillation respectively, get component 1 and component 2.Medicinal liquid after distillation device is in addition collected, and residue and Rhizoma Zingiberis Recens, Cortex Mori, Poria add 10 times of water gagings and decoct 3 times, each 1 hour, filters, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 3.

3) Fructus Schisandrae Chinensis that is ground into coarse powder, the Rhizoma Pinelliae of described weight proportion are measured 70% alcohol refluxs 3 times with 8 times, each 1 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 4.

4) merge component 3 and component 4, pulverize, spray adds component 1 and component 2, mixing, and tabletting, promptly.

The preparation of the tablet of [embodiment 4] pharmaceutical composition of the present invention

1) take by weighing each crude drug Fructus Mume 6g, Rhizoma Zingiberis Recens 3g, Herba Asari 6g, Cortex Mori 25g, Herba Menthae 6g, Rhizoma Pinelliae 12g or Poria 20g, standby.

2) with Herba Asari, Herba Menthae difference extracting in water volatile oil, get component 1 and component 2.Medicinal liquid after distillation device is in addition collected, and residue and Fructus Mume, Rhizoma Zingiberis Recens, Cortex Mori, Poria add 10 times of water gagings and decoct 3 times, each 1 hour, filters, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 3.

3) Rhizoma Pinelliae of described weight proportion is measured 70% alcohol refluxs 3 times with 8 times, each 1 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 4.

The preparation of the granule of [embodiment 5] pharmaceutical composition of the present invention

1) take by weighing each crude drug Fructus Schisandrae Chinensis 6g, Rhizoma Zingiberis Recens 3g, Herba Asari 6g, Cortex Lycii 25g, Periostracum Cicadae 6g, Herba Ephedrae 9g, Semen Armeniacae Amarum 9g, standby.

2) Herba Asari, Herba Menthae are collected volatile oil with steam distillation respectively, get component 1 and component 2.Medicinal liquid after distillation device is in addition collected, and residue adds 10 times of water gagings with Rhizoma Zingiberis Recens, Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum and decocts each 1 hour 3 times, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, get component 3.

3) Fructus Schisandrae Chinensis that is ground into coarse powder of described weight proportion is measured 70% alcohol refluxs 3 times with 8 times, each 1 hour, filter, merge extractive liquid,, decompression recycling ethanol gets component 4.

4) merge component 3 and become thick paste, add an amount of Icing Sugar, make soft material with component concentrating under reduced pressure below 4,60 ℃, extrusion granulator, dry below 60 ℃, spray adds component 1 and component 2, mixing, promptly.

The preparation of the granule of [embodiment 6] pharmaceutical composition of the present invention

1) take by weighing each crude drug Fructus Mume 6g, Rhizoma Zingiberis Recens 3g, Herba Asari 6g, Cortex Lycii 25g, Periostracum Cicadae 6g, Herba Ephedrae 9g, Semen Armeniacae Amarum 9g, standby.

2) Herba Asari, Herba Menthae are collected volatile oil with steam distillation respectively, get component 1 and component 2.Medicinal liquid after distillation device is in addition collected, and residue adds 10 times of water gagings with Fructus Mume, Rhizoma Zingiberis Recens, Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum and decocts each 1 hour 3 times, filter, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, get component 3.

3) component 3 becomes thick paste in concentrating under reduced pressure below 60 ℃, adds an amount of Icing Sugar, makes soft material, extrusion granulator, and dry below 60 ℃, spray adds component 1 and component 2, mixing, promptly.

The preparation of the capsule of [embodiment 7] pharmaceutical composition of the present invention

1) take by weighing each crude drug Fructus Schisandrae Chinensis 6g, Rhizoma Zingiberis Recens 3g, Herba Asari 6g, Cortex Mori 25g, standby.

2) Herba Asari is collected volatile oil with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, and residue and Rhizoma Zingiberis Recens, Cortex Mori add 10 times of water gagings decoctions 3 times, and each 1 hour, filtration merged all filtrates, is concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leaves standstill, and filters, and filtrate is concentrated, dry, gets component 2.

3) Fructus Schisandrae Chinensis that will be ground into coarse powder is measured 70% alcohol refluxs 3 times with 8 times, and each 1 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3.

4) merge component 2 and component 3, pulverize, spray adds component 1, mixing, and filled hard capsules, promptly.

The preparation of the capsule of [embodiment 8] pharmaceutical composition of the present invention

1) take by weighing each crude drug Fructus Mume 6g, Rhizoma Zingiberis Recens 3g, Herba Asari 6g, Cortex Mori 25g, standby.

2) Herba Asari is collected volatile oil with steam distillation, get component 1.Medicinal liquid after distillation device is in addition collected, and residue and Fructus Mume, Rhizoma Zingiberis Recens, Cortex Mori add 10 times of water gagings and decoct 3 times, each 1 hour, filters, merge all filtrates, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill, filter, filtrate is concentrated, dry, gets component 2.

3) component 2 sprays add component 1, mixing, and filled hard capsules, promptly.

Claims

One kind have cough-relieving, relieving asthma, the pharmaceutical composition of throat-moistening resolve phlegm effect, it is characterized in that the crude drug of this pharmaceutical composition is: Fructus Schisandrae Chinensis 3-15 weight portion, Rhizoma Zingiberis Recens 1-6 weight portion, Herba Asari 1-10 weight portion.
2. as the said pharmaceutical composition of claim 1, it is characterized in that the weight portion of each crude drug is: 3 parts of Rhizoma Zingiberis Recens, 6 parts of Fructus Schisandrae Chinensis, 6 parts of Herba Asaris.
3. pharmaceutical composition as claimed in claim 1 wherein replaces Fructus Schisandrae Chinensis 3-15 weight portion with Fructus Mume 3-15 weight portion.
4. pharmaceutical composition as claimed in claim 2 wherein replaces Fructus Schisandrae Chinensis 6 weight portions with Fructus Mume 6 weight portions.
5. each described preparation of drug combination method of claim 1-4, wherein:

When Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, when Herba Asari is crude drug, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, and the Rhizoma Zingiberis Recens of residue and described weight proportion adds 8～15 times of water gagings and decocts 1～3 time, each 1～3 hour, filters, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) Fructus Schisandrae Chinensis of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3;

4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Perhaps

When Fructus Mume, Rhizoma Zingiberis Recens, when Herba Asari is crude drug, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, and the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filters, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) pulverize component 2, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention.
One kind have cough-relieving, relieving asthma, the pharmaceutical composition of throat-moistening resolve phlegm effect, it is a crude drug with each described three flavor medical materials of claim 1-4, also adds Cortex Mori 6-40 weight portion or Cortex Lycii 6-40 weight portion.
7. pharmaceutical composition as claimed in claim 6 is characterized in that the weight portion of each crude drug is: 25 parts of 3 parts of Rhizoma Zingiberis Recens, 6 parts of Fructus Schisandrae Chinensis or 6 parts of Fructus Mumes, 6 parts of Herba Asaris, 25 parts of Cortex Mori or Cortex Lycii.
8. as preparation of drug combination method as described in claim 6 or 7, wherein:

When selecting Fructus Schisandrae Chinensis to be crude drug, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, and Cortex Mori or Cortex Lycii, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, the Rhizoma Zingiberis Recens of residue and described weight proportion, Cortex Mori or Cortex Lycii add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) Fructus Schisandrae Chinensis of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3;

4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

When selecting Fructus Mume to be crude drug, this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, and Cortex Mori or Cortex Lycii, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) component 2 is pulverized, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention.
9. pharmaceutical composition as claimed in claim 6, its crude drug also add Herba Menthae 3-9 weight portion or Periostracum Cicadae 3-9 weight portion.
10. pharmaceutical composition as claimed in claim 9 is characterized in that the weight portion of each crude drug is: 6 parts of 6 parts of 6 parts of Fructus Schisandrae Chinensis or Fructus Mumes, 3 parts of Rhizoma Zingiberis Recens, 6 parts of Herba Asaris, 25 parts of Cortex Mori or 25 parts of Cortex Lycii, 6 parts of Herba Menthaes or Periostracum Cicadaes.
11. as claim 9 or 10 described preparation of drug combination methods, wherein:

Work as Fructus Schisandrae Chinensis; Rhizoma Zingiberis Recens; Herba Asari; In Cortex Mori or the Cortex Lycii one; And Herba Menthae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Menthae, standby;

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2; Medicinal liquid after distillation device is in addition collected, the Rhizoma Zingiberis Recens of residue and described weight proportion, Cortex Mori or Cortex Lycii add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 3;

3) Fructus Schisandrae Chinensis of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 4;

4) merge component 3 and component 4, pulverize, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Perhaps

Work as Fructus Schisandrae Chinensis; Rhizoma Zingiberis Recens; Herba Asari; In Cortex Mori or the Cortex Lycii one; And Periostracum Cicadae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Periostracum Cicadae, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, the Rhizoma Zingiberis Recens of residue and described weight proportion, Cortex Mori or Cortex Lycii, Periostracum Cicadae add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) Fructus Schisandrae Chinensis of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3;

4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Perhaps

Work as Fructus Mume; Rhizoma Zingiberis Recens; Herba Asari; In Cortex Mori or the Cortex Lycii one; And Herba Menthae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Menthae, standby;

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2; Medicinal liquid after distillation device is in addition collected, the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 3;

3) component 3 is pulverized, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Perhaps

Work as Fructus Mume; Rhizoma Zingiberis Recens; Herba Asari; In Cortex Mori or the Cortex Lycii one; And Periostracum Cicadae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Periostracum Cicadae, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) component 2 is pulverized, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention.
12. pharmaceutical composition according to claim 6, its crude drug also add Rhizoma Pinelliae 5-20 weight portion or Poria 5-30 weight portion; With Herba Menthae 3-9 weight portion or Periostracum Cicadae 3-9 weight portion.
13. pharmaceutical composition as claimed in claim 12 is characterized in that the weight portion of each crude drug is: 6 parts of 6 parts of 6 parts of Fructus Schisandrae Chinensis or Fructus Mumes, 3 parts of Rhizoma Zingiberis Recens, 6 parts of Herba Asaris, 25 parts of Cortex Mori or 25 parts of Cortex Lycii, 12 parts of the Rhizoma Pinelliaes or 20 parts in Poria, 6 parts of Herba Menthaes or Periostracum Cicadaes.
14. as claim 12 or 13 described preparation of drug combination methods, wherein:

Work as Fructus Schisandrae Chinensis; Rhizoma Zingiberis Recens; Herba Asari; The Rhizoma Pinelliae; In Cortex Mori or the Cortex Lycii one; And Herba Menthae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, the Rhizoma Pinelliae, Cortex Mori or Cortex Lycii, Herba Menthae, standby;

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2; Medicinal liquid after distillation device is in addition collected, the Rhizoma Zingiberis Recens of residue and described weight proportion, Cortex Mori or Cortex Lycii add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 3;

3) Fructus Schisandrae Chinensis, the Rhizoma Pinelliae of described weight proportion are measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 4;

4) merge component 3 and component 4, pulverize, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Schisandrae Chinensis; Rhizoma Zingiberis Recens; Herba Asari; The Rhizoma Pinelliae; In Cortex Mori or the Cortex Lycii one; And Periostracum Cicadae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, the Rhizoma Pinelliae, Cortex Mori or Cortex Lycii, Periostracum Cicadae, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, the Rhizoma Zingiberis Recens of residue and described weight proportion, Cortex Mori or Cortex Lycii, Periostracum Cicadae add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) Fructus Schisandrae Chinensis, the Rhizoma Pinelliae of described weight proportion are measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3;

4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Schisandrae Chinensis; Rhizoma Zingiberis Recens; Herba Asari; Poria; In Cortex Mori or the Cortex Lycii one; And Herba Menthae is when being adjuvant drug, and this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Poria, Herba Menthae, standby;

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2; Medicinal liquid after distillation device is in addition collected, the Rhizoma Zingiberis Recens of residue and described weight proportion, Cortex Mori or Cortex Lycii, Poria add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 3;

3) Fructus Schisandrae Chinensis of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 4;

4) merge component 3 and component 4, pulverize, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Schisandrae Chinensis; Rhizoma Zingiberis Recens; Herba Asari; Poria; In Cortex Mori or the Cortex Lycii one; And Periostracum Cicadae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Poria, Periostracum Cicadae, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, the Rhizoma Zingiberis Recens of residue and described weight proportion, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Poria add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) Fructus Schisandrae Chinensis of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3;

4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Mume; Rhizoma Zingiberis Recens, Herba Asari; The Rhizoma Pinelliae; In Cortex Mori or the Cortex Lycii one; And Herba Menthae is when being adjuvant drug, and this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, the Rhizoma Pinelliae, Herba Menthae, standby;

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2; Medicinal liquid after distillation device is in addition collected, the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 3;

3) Rhizoma Pinelliae of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 4;

4) merge component 3 and component 4, pulverize, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Mume; Rhizoma Zingiberis Recens, Herba Asari; The Rhizoma Pinelliae; In Cortex Mori or the Cortex Lycii one; And Periostracum Cicadae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, the Rhizoma Pinelliae, Periostracum Cicadae, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) Rhizoma Pinelliae of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3;

4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Mume; Rhizoma Zingiberis Recens; Herba Asari; Poria; In Cortex Mori or the Cortex Lycii one; And Herba Menthae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Poria, Herba Menthae, standby;

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2; Medicinal liquid after distillation device is in addition collected, the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Poria add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 3;

3) component 3 is pulverized, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Mume; Rhizoma Zingiberis Recens; Herba Asari; Poria; In Cortex Mori or the Cortex Lycii one; And Periostracum Cicadae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Poria, Periostracum Cicadae, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, the Fructus Mume of residue and described weight proportion, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Poria add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) component 2 is pulverized, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention.
15. want 6 described medicines according to right, its crude drug also adds Herba Ephedrae 3-15 weight portion, Semen Armeniacae Amarum 3-15 weight portion and Herba Menthae 3-9 weight portion or Periostracum Cicadae 3-9 weight portion.
16. medicine as claimed in claim 15 is characterized in that the weight portion of each crude drug is: 6 parts of 6 parts of 6 parts of Fructus Schisandrae Chinensis or Fructus Mumes, 3 parts of Rhizoma Zingiberis Recens, 6 parts of Herba Asaris, 25 parts of Cortex Mori or 25 parts of Cortex Lycii, 9 parts in Herba Ephedrae, 9 parts in Semen Armeniacae Amarum, 6 parts of Herba Menthaes or Periostracum Cicadaes.
17. as claim 15 or 16 described preparation of drug combination methods, wherein:

Work as Fructus Schisandrae Chinensis; Rhizoma Zingiberis Recens; Herba Asari; Herba Ephedrae; Semen Armeniacae Amarum; In Cortex Mori or the Cortex Lycii one; And Herba Menthae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Herba Menthae, standby;

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2; Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Herba Ephedrae, the Semen Armeniacae Amarum of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 3;

3) Fructus Schisandrae Chinensis of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 4;

4) merge component 3 and component 4, pulverize, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Schisandrae Chinensis; Rhizoma Zingiberis Recens; Herba Asari; Herba Ephedrae; Semen Armeniacae Amarum; In Cortex Mori or the Cortex Lycii one; And Periostracum Cicadae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Periostracum Cicadae, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, the Semen Armeniacae Amarum of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) Fructus Schisandrae Chinensis of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3;

4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Mume; Rhizoma Zingiberis Recens; Herba Asari; Herba Ephedrae; Semen Armeniacae Amarum; In Cortex Mori or the Cortex Lycii one; And Herba Menthae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Herba Menthae, standby;

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2; Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Fructus Mume, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Herba Ephedrae, the Semen Armeniacae Amarum of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 3;

3) component 3 is pulverized, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Mume; Rhizoma Zingiberis Recens; Herba Asari; Herba Ephedrae; Semen Armeniacae Amarum; In Cortex Mori or the Cortex Lycii one; And Periostracum Cicadae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Periostracum Cicadae, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Fructus Mume, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, the Semen Armeniacae Amarum of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) component 2 is pulverized, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention.
18. medicine according to claim 6, its crude drug can also add Rhizoma Pinelliae 5-20 weight portion or Poria 5-30 weight portion, Herba Ephedrae 3-15 weight portion, Semen Armeniacae Amarum 3-15 weight portion, Herba Menthae 3-9 weight portion or Periostracum Cicadae 3-9 weight portion.
19. pharmaceutical composition as claimed in claim 18, wherein the weight portion of crude drug is 6 parts of 6 parts of Fructus Schisandrae Chinensis or 6 parts of Fructus Mumes, 3 parts of Rhizoma Zingiberis Recens, 6 parts of Herba Asaris, 25 parts of Cortex Mori or 25 parts of Cortex Lycii, 9 parts in Herba Ephedrae, 9 parts in Semen Armeniacae Amarum, 12 parts of the Rhizoma Pinelliaes or 20 parts in Poria, 6 parts of Herba Menthaes or Periostracum Cicadaes.
20. as claim 18 or 19 described preparation of drug combination methods, wherein:

Work as Fructus Schisandrae Chinensis; Rhizoma Zingiberis Recens; Herba Asari; Herba Ephedrae; Semen Armeniacae Amarum; The Rhizoma Pinelliae; In Cortex Mori or the Cortex Lycii one; And Herba Menthae is when being adjuvant drug, and this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Herba Menthae, standby;

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2; Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Herba Ephedrae, the Semen Armeniacae Amarum of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 3;

3) Fructus Schisandrae Chinensis, the Rhizoma Pinelliae of described weight proportion are measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 4;

4) merge component 3 and component 4, pulverize, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Schisandrae Chinensis; Rhizoma Zingiberis Recens; Herba Asari; Herba Ephedrae; Semen Armeniacae Amarum; The Rhizoma Pinelliae; In Cortex Mori or the Cortex Lycii one; When being crude drug with Periostracum Cicadae, this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Periostracum Cicadae, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, the Semen Armeniacae Amarum of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) Fructus Schisandrae Chinensis, the Rhizoma Pinelliae of described weight proportion are measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3;

4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Schisandrae Chinensis; Rhizoma Zingiberis Recens; Herba Asari; Herba Ephedrae; Semen Armeniacae Amarum; Poria; In Cortex Mori or the Cortex Lycii one; And Herba Menthae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Poria, Herba Menthae, standby;

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2; Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, the Poria of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 3;

3) Fructus Schisandrae Chinensis of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 4;

4) merge component 3 and component 4, pulverize, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Schisandrae Chinensis; Rhizoma Zingiberis Recens; Herba Asari; Herba Ephedrae; Semen Armeniacae Amarum; Poria; In Cortex Mori or the Cortex Lycii one; And Periostracum Cicadae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Poria, Periostracum Cicadae, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum, the Poria of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) Fructus Schisandrae Chinensis of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3;

4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Mume; Rhizoma Zingiberis Recens; Herba Asari; Herba Ephedrae; Semen Armeniacae Amarum; The Rhizoma Pinelliae; In Cortex Mori or the Cortex Lycii one; And Herba Menthae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Herba Menthae, standby;

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2; Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Fructus Mume, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Herba Ephedrae, the Semen Armeniacae Amarum of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 3;

3) Rhizoma Pinelliae of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 4;

4) merge component 3 and component 4, pulverize, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Mume; Rhizoma Zingiberis Recens; Herba Asari; Herba Ephedrae; Semen Armeniacae Amarum; The Rhizoma Pinelliae; In Cortex Mori or the Cortex Lycii one; And Periostracum Cicadae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Periostracum Cicadae, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Fructus Mume, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, the Semen Armeniacae Amarum of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) Rhizoma Pinelliae of described weight proportion is measured 60%～95% alcohol refluxs 1～4 time with 6～10 times, each 0.5～3 hour, filter, merge extractive liquid,, decompression recycling ethanol, drying under reduced pressure below 60 ℃ gets component 3;

4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Mume; Rhizoma Zingiberis Recens; Herba Asari; Herba Ephedrae; Semen Armeniacae Amarum; Poria; In Cortex Mori or the Cortex Lycii one; And Herba Menthae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Poria, Herba Menthae, standby;

2) Herba Asari, the Herba Menthae of described weight proportion are collected distillate with steam distillation respectively, get component 1 and component 2; Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Fructus Mume, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, the Poria of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 3;

3) component 3 is pulverized, spray adds component 1 and component 2, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention;

Work as Fructus Mume; Rhizoma Zingiberis Recens; Herba Asari; Herba Ephedrae; Semen Armeniacae Amarum, Poria; In Cortex Mori or the Cortex Lycii one; And Periostracum Cicadae is when being crude drug, and this preparation method is:

1) take by weighing each crude drug Fructus Mume, Rhizoma Zingiberis Recens, Herba Asari, Cortex Mori or Cortex Lycii, Herba Ephedrae, Semen Armeniacae Amarum, Poria, Periostracum Cicadae, standby;

2) Herba Asari of described weight proportion is collected distillate with steam distillation, get component 1; Medicinal liquid after distillation device is in addition collected, residue adds 8～15 times of water gagings decoctions 1～3 time with Fructus Mume, Rhizoma Zingiberis Recens, Cortex Mori or Cortex Lycii, Periostracum Cicadae, Herba Ephedrae, Semen Armeniacae Amarum, the Poria of described weight proportion, each 1～3 hour, filter, merge all filtrates, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill, filter, filtrate is concentrated, dry, gets component 2;

3) component 2 is pulverized, spray adds component 1, and mixing just has been prepared into active ingredient in pharmaceutical of the present invention.
21. as claim 1,2,3,4,6,7,9,10,12,13,15,16,18 or 19 arbitrary described pharmaceutical compositions have cough-relieving in preparation, relieving asthma, purposes in the medicine of throat-moistening resolve phlegm effect.