CN101249243B - Chinese medicine for curing acute leukemia - Google Patents
Chinese medicine for curing acute leukemia Download PDFInfo
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- CN101249243B CN101249243B CN2008100913635A CN200810091363A CN101249243B CN 101249243 B CN101249243 B CN 101249243B CN 2008100913635 A CN2008100913635 A CN 2008100913635A CN 200810091363 A CN200810091363 A CN 200810091363A CN 101249243 B CN101249243 B CN 101249243B
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Abstract
The invention discloses a Chinese drug which has specific effect on the treatment of the acute leukemia. The invention composes the compositions according to the proportion by weight as follows: gypsum 5 to 40 g, anemarrhena 4 to 20 g, buffalo horn 10 to 30 g, dried rehmannia root 5 to 30 g, moutan bark 5 to 20 g, Chinese goldthread 4 to 15 g, baikal skullcap root 5 to 30 g, rhubarb 3 to10 g, honey suckle 5 to 30 g, capsule of weeping forsythia 5 to 20 g, epimeddium 5 to 30 g, fruit of barbary wolf berry 5 to 30 g, oldenlandia 5 to 20 g, astragalus root 10 to 50 g, red sage root 10 to 40 g, umbellate ore fungus 5 to 15 g, atractylodes macrocephala 5 to 20 g, indian bread 5 to 20 g, licorice root 4 to 20 g, rhizome of Sichuan lovage 5 to 15 g, cordate houttuynia 5 to 30 g, commonreed rhizome 5 to 30 g, polygala root 5 to 15 g, seed of spine date 5 to 15 g, amomum fruit 5 to 15 g, curculigo rhizome 5 to 20 g, Chinese angelica root 5 to 20 g and barbed stullcap 4 to 20 g, wherein the epimeddium, the astragalus root, the fruit of barbary wolf berry and the dried rehmannia root are the monarch drugs; the honey suckle, the baikal skullcap root, the red sage root, the oldenlandia, the cypsum fibrosum and the cordate houttuynia are ministerial drugs; and the polygala root, the seed of spine date and the licorice root are subsidiary drugs. The drug has specific effect for preventing and curing the leukemia with infection, arresting bone marrow, correcting the low immunity and quick recovering the blood item, the red corpuscle, the white corpuscle, the blood platelet and the haemoglobin, and has the advantages that the treatment cost is low, the course of treatment is short and the drug has no side effects.
Description
Technical field:
The present invention relates to a kind of Chinese medicine for the treatment of acute leukemia, make, belong to the field of Chinese medicines by pure Chinese medicine.
Background technology:
Leukemia is the malignant disease of hemopoietic system, is commonly called as " leukemia ", is one of domestic ten big malignant tumor occurred frequently.The acute leukemia morbidity is anxious, mainly be germinal cell in bone marrow and the peripheral blood, during morbidity in the bone marrow leukaemia breed in a large number, and extensively soak into liver, various internal organs such as spleen, lymph node, suppress normal hematopoiesis, mainly show as signs such as anemia, infection, hemorrhage and infiltration.Combined chemotherapy is a kind of main Therapeutic Method of present acute leukemia, the length of bone marrow depression phase directly affects the treatment after the chemotherapy, and in this stage because the generation of hemocyte attenuating, infection, heating, clinical picture such as hemorrhage directly jeopardizes patient's life.Therefore shorten the bone marrow depression phase, avoid taking place during this period severe infections and hemorrhage phenomenon is current treatment acute leukemia problem demanding prompt solution.
Summary of the invention:
The object of the invention provides bone marrow depression after a kind of effective treatment chemotherapy of acute leukemia, infection and hemorrhage Chinese medicine composition.
Be the bone marrow depression phase behind the shortening chemotherapy of patients, avoid taking place severe infections and hemorrhage problem, improve immunity, suppressing leukemia shifts, impel apoptosis of leukemia, kill virus, antibacterial, mycete, effectively remove the endotoxin of pathogenic bacterium, the inventor according to theory of Chinese medical science, in conjunction with the modern medicine technology with in 40 years, the leukemic clinical verification of western medical treatment, a kind of Chinese medicine for the treatment of acute leukemia is disclosed.
The present invention be with Gypsum Fibrosum, the Rhizoma Anemarrhenae, Cornu Bubali, the Radix Rehmanniae, Cortex Moutan, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Flos Lonicerae, Fructus Forsythiae, Herba Epimedii, Fructus Lycii, Herba Hedyotidis Diffusae, the Radix Astragali, Radix Salviae Miltiorrhizae, Polyporus, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Rhizoma Chuanxiong, Herba Houttuyniae, Rhizoma Phragmitis, Radix Polygalae, Semen Ziziphi Spinosae, Fructus Amomi, Rhizoma Curculiginis, Radix Angelicae Sinensis, Herba Scutellariae Barbatae according to state of an illness flexible combination, to shorten the bone marrow depression phase, the control acute leukemia is infected, hemorrhage and improve immunity, make hemogram, erythrocyte, leukocyte, platelet, hemoglobin is able to fast quick-recovery that specially good effect is normally arranged.
Wherein Herba Epimedii acrid-sweet flavor temperature is returned the Liver and kidney warp.The effect that kidney invigorating and YANG supporting, expelling wind and removing dampness, strengthening the tendons and bones are arranged particularly has specially good effect to hematoblastic gathering.The Radix Astragali is sweet in flavor and warm in property, returns the lung spleen channel.The effect of invigorating QI to consolidate the body surface resistance, hidroschesis detoxification, granulation promoting, diuresis, detumescent is arranged, and include multiple antibiotic effective ingredient, therefore the energy enhancing body's immunological function can also be used to prevent the generation of some infectious disease.The Fructus Lycii nature and flavor are sweet flat, return liver stomach lung meridian, the kidney invigorating and essence nourishing, and nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough is used for the treatment of hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tears of blurred vision, cough due to consumptive disease, the seminal emission of quenching one's thirst, and obvious antineoplastic is arranged.Radix Rehmanniae nature and flavor sweetness and bitterness is cold, GUIXIN liver lung meridian.Clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting is used for the warm febrile disease blood of joining the army, and the heat in blood poison is contained, hematemesis and epistaxis, Tianjin wound is thirsty, and interior-heat is quenched one's thirst.This four Chinese medicine is a monarch drug, focuses on kidney invigorating and YANG supporting, invigorating QI to consolidate the body surface resistance, the kidney invigorating and essence nourishing, blood-enriching tranquillizing, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.
Flos Lonicerae is sweet in flavor and cold in property, returns lung stomach warp.Heat-clearing and toxic substances removing is used for epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle treatment skin ulcer, sore throat and multiple infectious disease.Radix Scutellariae nature and flavor bitter cold, GUIXIN lung stomach gallbladder large intestine channel.Effect with heat clearing and damp drying, eliminating fire and detoxication, arresting bleeding and miscarriage prevention is used for damp and hot, pyretic toxicity disease, heat in blood is hemorrhage.Radix Salviae Miltiorrhizae nature and flavor hardship is slightly cold, GUIXIN, pericardium, Liver Channel.Blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, nourishing blood to tranquillize the mind, the removing heat from blood eliminating carbuncle also has antibiotic, antitumor, gathering platelet and coagulation function.Herba Hedyotidis Diffusae is sweet in flavor and warm in property, and is nontoxic.GUIXIN liver spleen channel.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain has antitumor, antibiotic anti-antiinflammation.Be used for dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat and cancerous protuberance etc.The Gypsum Fibrosum acrid-sweet flavor is cold, returns lung stomach warp.Expelling pathogenic factors from muscles for clearing heat, relieving restlessness is quenched the thirst, and is used for the calentura high fever and does not move back, vexed coma, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, hyperactivity of toxic heat.The Herba Houttuyniae property and flavor of peppery and cold is returned the liver lung meridian.Effect with heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome is used for the lung abscess vomiting pus, and the expectorant dyspnea of heat type is coughed, carbuncle sore tumefacting virus.This Six-element medicine is a ministerial drug, focuses on heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, nourishing blood to tranquillize the mind, removing heat from blood eliminating carbuncle.
The Radix Polygalae nature and flavor tepor of working hard, GUIXIN liver spleen kidney channel.Mind tranquilizing and the heart calming eliminates the phlegm and has one's ideas straightened out, and removing toxic substances and promoting subsidence of swelling is used for the palpitation with fear insomnia, cough with copious phlegm, and the carbuncle carbuncle on the back, antibacterial anticancer.The Radix Glycyrrhizae nature and flavor are flat sweet, return taste cardiopulmonary warp.Detoxifcation arranged, eliminate the phlegm, pain relieving, spasmolytic, coordinating the actions of various ingredients in a prescription be so that anticancer effect is used for the leanness yellowish complexion, shortness of breath and palpitation, the stomachache loose stool, cough and asthma, laryngopharynx swelling and pain, the carbuncle skin ulcer swells and ache and medicine, alimentary toxicosis.The sweet acid of Semen Ziziphi Spinosae nature and flavor is flat, GUIXIN spleen liver and gall warp.Mind tranquilizing and the heart calming, nourishing the liver, arresting sweating.Be used for restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, the empty spontaneous perspiration of body, night sweat.This three flavors medicine is an accessory drugs, and common assistant helps the monarch and his subjects' product removing toxic substances and promoting subsidence of swelling, mind tranquilizing and the heart calming.
The traditional Chinese medical science is thought: acute leukemia is arrived by void.By positive QI-insufficiency, virus attack, going from the exterior into the interior, it is cloudy to injure battalion, undermines bone marrow, interior-heat fumigation then, heat damaging blood and vessels, the absurd row of forcing blood, or the temperature poison holder impairment of QI-blood, QI failing to control blood then, hemorrhage all diseases take place in failure of the spleen to keep the blood flowing within the vessels.Nutrient blood heat is vehement, and visible hyperpyrexia causes the state of an illness to further develop, and worsens more, exhausts and dead to negative and positive two, and its cause of the death is many to be caused by infection, hyperpyrexia or intracranial hemorrhage etc.In a word, leukemia is a vital QI being weakened and pathogen being violent, the disease of simulataneous insufficiency and excessive.Vital essence void is endogenous cause of ill, and warm viral disease heresy is an exopathogenic factor.The pathogenic process of acute leukemia is that healthy energy resists, has void that the assorted mutually complex process of reality, deficiency and excess is arranged with the evil of temperature poison mutually.
By monarch drug (Herba Epimedii, the Radix Astragali, Fructus Lycii, the Radix Rehmanniae), ministerial drug (Flos Lonicerae, Radix Scutellariae, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, Gypsum Fibrosum, Herba Houttuyniae), accessory drugs (Radix Polygalae, Radix Glycyrrhizae, Semen Ziziphi Spinosae) in addition the Chinese medicine made of the Rhizoma Anemarrhenae, Cornu Bubali, Cortex Moutan, Rhizoma Coptidis, Radix Et Rhizoma Rhei, Fructus Forsythiae, Polyporus, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Chuanxiong, Rhizoma Phragmitis, Fructus Amomi, Rhizoma Curculiginis, Radix Angelicae Sinensis, Herba Scutellariae Barbatae shortened bone marrow depression phase of acute leukemia, suppress leukaemia's transfer and made the leukaemia dead fast, thereby improved leukemic remission rate and cure rate.
The consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, and each amounts of components is for all having curative effect in the following weight parts scope.
Gypsum Fibrosum 5-40g, Rhizoma Anemarrhenae 4-20g, Cornu Bubali 10-30g, Radix Rehmanniae 5-30g, Cortex Moutan 5-20g, Rhizoma Coptidis 4-15g, Radix Scutellariae 5-30g, Radix Et Rhizoma Rhei 3-10g, Flos Lonicerae 5-30g, Fructus Forsythiae 5-20g, Herba Epimedii 5-30g, Fructus Lycii 5-30g, Herba Hedyotidis Diffusae 5-20g, Radix Astragali 10-50g, Radix Salviae Miltiorrhizae 10-40g, Polyporus 5-15g, Rhizoma Atractylodis Macrocephalae 5-20g, Poria 5-20g, Radix Glycyrrhizae 4-20g, Rhizoma Chuanxiong 5-15g, Herba Houttuyniae 5-30g, Rhizoma Phragmitis 5-30g, Radix Polygalae 5-15g, Semen Ziziphi Spinosae 5-15g, Fructus Amomi 5-15g, Rhizoma Curculiginis 5-20g, Radix Angelicae Sinensis 5-20g, Herba Scutellariae Barbatae 4-20g.
Optimization formula is: Gypsum Fibrosum 30g, Rhizoma Anemarrhenae 10g, Cornu Bubali 30g, Radix Rehmanniae 20g, Cortex Moutan 12g, Rhizoma Coptidis 6g, Radix Scutellariae 10g, Radix Et Rhizoma Rhei 4g, Flos Lonicerae 15g, Fructus Forsythiae 15g, Herba Epimedii 15g, Fructus Lycii 20g, Herba Hedyotidis Diffusae 12g, Radix Astragali 30g, Radix Salviae Miltiorrhizae 20g, Polyporus 10g, Rhizoma Atractylodis Macrocephalae 10g, Poria 12g, Radix Glycyrrhizae 6g, Rhizoma Chuanxiong 12g, Herba Houttuyniae 15g, Rhizoma Phragmitis 15g, Radix Polygalae 10g, sand Semen Ziziphi Spinosae 10g, Fructus Amomi 5g, Rhizoma Curculiginis 12g, Radix Angelicae Sinensis 12g, Herba Scutellariae Barbatae 10g.
Gypsum Fibrosum described in the present invention is a Gypsum Fibrosum.
The specific implementation method of medicine of the present invention is as follows:
At first Gypsum Fibrosum 30g is added water 100ml and boil again slow fire and boiled 20 minutes, pour in the marmite standby.Again Rhizoma Anemarrhenae 10g, Cornu Bubali 30g, Radix Rehmanniae 20g, Cortex Moutan 12g, Rhizoma Coptidis 6g, Radix Scutellariae 10g, Radix Et Rhizoma Rhei 4g, Flos Lonicerae 15g, Fructus Forsythiae 15g, Herba Epimedii 15g, Fructus Lycii 20g, Herba Hedyotidis Diffusae 12g, Radix Astragali 30g, Radix Salviae Miltiorrhizae 20g, Polyporus 10g, Rhizoma Atractylodis Macrocephalae 10g, Poria 12g, Radix Glycyrrhizae 6g, Rhizoma Chuanxiong 12g, Herba Houttuyniae 15g, Rhizoma Phragmitis 15g, Radix Polygalae 10g, sand Semen Ziziphi Spinosae 10g, Fructus Amomi 5g, Rhizoma Curculiginis 12g, Radix Angelicae Sinensis 12g, Herba Scutellariae Barbatae 10g add in the lump and add clear water 500ml immersion 30 minutes in the marmite.
First juice: changed slow fire after intense fire is boiled 10 minutes, it is standby to pour out juice 250ml, adds clear water 300ml again;
Second juice: changed slow fire after intense fire is boiled 20 minutes, and medicine juice was poured out all mix the back with first juice standby.
Divide twice medicine juice meter 500ml one day secondary to take, seven days is a course of treatment.
Patient treatment convalescence points for attention:
One, forbids to contact paint, benzene, gasoline etc.;
Two, note Personal hygiene, wear masks after the chemotherapy that anti-respiratory tract infection also will be noted digestive tract infection.
Below be that the present invention treats acute leukemia part case:
Case one:
Li Xianfeng, man, 27 years old.Be diagnosed as acute myeloblastic leukemia M because of febrile disease through the Henan examination in hospital in March, 1997
2, blood examination HB40g/L, WBC40 * 10
9/ L, BPC20 * 10
9/ L is not alleviated through treatment.After give this treatment by Chinese herbs seven days, blood examination HB138g/L, WBC 6.8 * 10
9/ L, WBC 289g * 10
9/ L share to reach fully with DAT scheme after the course of treatment and alleviates.Took Chinese medicine in every month afterwards seven days, Western medicine combined chemotherapy also seven days.Inactive Chinese medicine and Western medicine after ten courses of treatment.Now alleviated 11 years, healthy.
Case two:
Fourth is beautiful, woman, 7 years old, in October, 1997 morbidity.Through the diagnosis of being in hospital, bone marrow examination is ALL, blood examination HB46g/L, WBC1.7 * 10
9/ L, BPC/18 * 10
9/ L, heating is not moved back after the chemotherapy, and is invalid with the Western medicine antibiotic therapy.Give this treatment by Chinese herbs (all doses all reduce by half) after three days body temperature normal, consolidate drug withdrawal after four days, blood examination HB128g/L, WBC4.8 * 10
9/ L, BPC268 * 10
9/ L.Annual afterwards chemotherapy once cooperates this treatment by Chinese herbs, and existing this leukemia of children is alleviated 11 years fully.
Case three:
Chou Meiyan, the woman, 31 years old, 2005 because of recurrent dizziness, examined on inspection to be leukemia M
2, heating is not moved back after the chemotherapy, the antibiotic of stopping using, blood examination HB50g/L, WBC35 * 10
9/ L, BPC30 * 10
9/ L.After give this treatment by Chinese herbs, take medicine that body temperature is normal two days later, blood examination HB138g/L, WBC4.6 * 10
9/ L, BPC286 * 10
9/ L consolidates drug withdrawal in four days, and later on each Western medicine chemotherapy adds with this treatment by Chinese herbs 7 days, finishes treatment smoothly, and patient in inactive western medicines in treatment of in April, 2007, is now alleviated.
Case four:
Hou Chengbing, the man, 16 years old, be diagnosed as MDS-RAEB because of yellowish complexion is weak to examination in hospital in January, 2008, myeloblast 18% in the bone marrow, and blood HB is low, and platelet is low.Once red cells transfusion, platelet treatment, blood examination HB40g/L, WBC0.8 * 10
9/ L, BPC27 * 10
9/ L.This treatment by Chinese herbs is used in the back, and appetite is good after seven days, blood examination HB127g/L, WBC1.4 * 10
9/ L, BPC279 * 10
9/ L, leukemia is now alleviated.
Case five:
Jiang Liyun, the man, 37 years old, in October, 2000, go out acute lymphoblastic leukemia through examination in hospital, forwarding Tianjin to is in hospital after the chemotherapy, the heating of bone marrow depression phase is surplus January, every day, body temperature was more than 40 ℃, hemoculture is the golden yellow staphylococcus of drug resistance, once used the 3rd, the cephalosporins treatment of four generations is in addition with rising the erythrocyte erythropoietin, a leukocyte grain born of the same parents cell growth factor, the medicine of platelet thrombocytosis is all invalid, discharge diagnosis: the bone marrow depression phase after the ALL chemotherapy, hydrothorax, pericardial effusion, pneumonia (the golden yellow staphylococcus of drug resistance), liver function injury, renal insufficiency, oral cavity infection, perianal infection, electrolyte disturbance.Take the preceding blood examination HB45g/L of this Chinese medicine, WBC0.3 * 10
9/ L, BPC10 * 10
9/ L takes six days blood examination HB110g/L of this Chinese medicine, WBC6.3 * 10
9/ L, BPC128 * 10
9/ L.Did bone marrow examination on the 7th day, alleviate fully, continued to take this Chinese medicine combined with chemotherapy after leaving hospital continuous 3 years, leukemia is alleviated fully.
Claims (2)
1. a Chinese medicine for the treatment of acute leukemia is characterized in that it is to be made by following materials of weight proportions medicine: Gypsum Fibrosum 5-40g, Rhizoma Anemarrhenae 4-20g, Cornu Bubali 10-30g, Radix Rehmanniae 5-30g, Cortex Moutan 5-20g, Rhizoma Coptidis 4-15g, Radix Scutellariae 5-30g, Radix Et Rhizoma Rhei 3-10g, Flos Lonicerae 5-30g, Fructus Forsythiae 5-20g, Herba Epimedii 5-30g, Fructus Lycii 5-30g, Herba Hedyotidis Diffusae 5-20g, Radix Astragali 10-50g, Radix Salviae Miltiorrhizae 10-40g, Polyporus 5-15g, Rhizoma Atractylodis Macrocephalae 5-20g, Poria 5-20g, Radix Glycyrrhizae 4-20g, Rhizoma Chuanxiong 5-15g, Herba Houttuyniae 5-30g, Rhizoma Phragmitis 5-30g, Radix Polygalae 5-15g, Semen Ziziphi Spinosae 5-15g, Fructus Amomi 5-15g, Rhizoma Curculiginis 5-20g, Radix Angelicae Sinensis 5-20g, Herba Scutellariae Barbatae 4-20g.
2. according to the medicine of claim 1, wherein the consumption of each crude drug is: Gypsum Fibrosum 30g, Rhizoma Anemarrhenae 10g, Cornu Bubali 30g, Radix Rehmanniae 20g, Cortex Moutan 12g, Rhizoma Coptidis 6g, Radix Scutellariae 10g, Radix Et Rhizoma Rhei 4g, Flos Lonicerae 15g, Fructus Forsythiae 15g, Herba Epimedii 15g, Fructus Lycii 20g, Herba Hedyotidis Diffusae 12g, Radix Astragali 30g, Radix Salviae Miltiorrhizae 20g, Polyporus 10g, Rhizoma Atractylodis Macrocephalae 10g, Poria 12g, Radix Glycyrrhizae 6g, Rhizoma Chuanxiong 12g, Herba Houttuyniae 15g, Rhizoma Phragmitis 15g, Radix Polygalae 10g, Semen Ziziphi Spinosae 10g, Fructus Amomi 5g, Rhizoma Curculiginis 12g, Radix Angelicae Sinensis 12g, Herba Scutellariae Barbatae 10g.
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Cited By (1)
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| US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101569720B (en) * | 2009-06-16 | 2010-11-10 | 杨桦 | Miao Nationality drug for treating leukemia |
| US9066974B1 (en) | 2010-11-13 | 2015-06-30 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| CN102727707A (en) * | 2011-04-14 | 2012-10-17 | 张建民 | Pharmaceutical composition for treating leukemia and aplastic anemia |
| CN103272054B (en) * | 2013-06-14 | 2015-05-13 | 袁军清 | Traditional Chinese medicine for treating leukemia |
| CN104306667A (en) * | 2014-11-24 | 2015-01-28 | 毛艳玲 | Mixed traditional Chinese medicine for treating acute leukemia |
| CN112516235A (en) * | 2021-02-01 | 2021-03-19 | 马宇振 | Pharmaceutical composition for treating leukemia and application thereof |
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| CN1243721A (en) * | 1998-07-31 | 2000-02-09 | 张发誉 | Medicinal pill for treating leukemia |
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| CN1243721A (en) * | 1998-07-31 | 2000-02-09 | 张发誉 | Medicinal pill for treating leukemia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
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