CN101229267A - Medicine compounds for pulmonary and rheumatic heart disease and preparing method thereof - Google Patents
Medicine compounds for pulmonary and rheumatic heart disease and preparing method thereof Download PDFInfo
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- CN101229267A CN101229267A CNA200810056134XA CN200810056134A CN101229267A CN 101229267 A CN101229267 A CN 101229267A CN A200810056134X A CNA200810056134X A CN A200810056134XA CN 200810056134 A CN200810056134 A CN 200810056134A CN 101229267 A CN101229267 A CN 101229267A
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Abstract
The invention discloses a medical combination for treating pulmonary heart disease and rheumatic heart disease and the preparation method thereof; the invention is prepared by peach kernel, safflower, angelica, charles abraham, Szechwan Lovage Rhizome, red peony root, achyranthes root, balloonflower root, bupleurum, citrus aurantium, and licorice. The medical combination of the invention has the efficacy of activating blood, promoting qi and ending pains, mainly for the treatment of pulmonary heart disease, rheumatic heart disease, the chest pain and headache caused by the clotted blood and the unsmooth blood flow in the chest, and also for coronary angina pectoris, chest contusion, rib chondritis chest pain, neurosis, deprementia of the concussion of brain sequela, dizziness headache, and other diseases. The invention has the advantages of simple formula, easy production, convenient taking by the patients, obvious efficacy, and wide application value.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, belong to the technical field of pharmaceuticals of activating blood circulation to dissipate blood stasis and promoting the circulation of QI to relieve pain.Cure mainly pulmonary heart disease, rheumatic heart disease and the chest pain headache due to blood stasis and the hematogenous blockage in the heart, card see the vertigo, sputum stay long-pending do not loose, chest and diaphragm painful abdominal mass plug, side of body rib distension, headache are disliked contrary, the cough of panting, tears saliva is sticky, uneasy in either sitting or lying, diet are not thought, white and greasy fur and deep and stringy pulse, or liver-wind holds expectorant, vomiting and unable to take food etc. under the arm, can be used for also treating that angina pectoris, chest are dampened, diseases such as the spirit depressing of the chest pain of costal chondritis, neurosis, cerebral concussion sequela and dizziness headache.
Background technology
Pulmonary heart disease and rheumatic heart disease are one of at present more common diseases, and the patient is in the majority with middle-aged and elderly people, and serious harm is healthy, and its sickness rate presents ascendant trend year by year in recent years.The cause of disease of pulmonary heart disease and rheumatic heart disease is because chronic bronchitis and bronchial asthma cause that painstaking effort are retarded by silt, blockage of the cardiac vessels, causes and blood stasis and hematogenous blockage in the heart, thereby the chest pain headache, cause cardiorespiratory pathogenesis to form.The traditional Chinese medical science thinks that pathogenesis belongs to pulmonary distension, cardiopalmus and asthma category, mostly be imbalance of YIN and YANG, the contrary unrest of mechanism of qi causes, therefore treat pulmonary heart disease, rheumatic heart disease and in the heart the chest pain headache due to blood stasis and the hematogenous blockage should defer to the pain relieving of traditional Chinese medical science blood circulation and channel invigorating, be aided with the method that invigorates vital energy and reinforce the heart, activating blood circulation to dissipate blood stasis and promoting the circulation of QI to relieve pain are to reach therapeutic effect.
At present the method for therapy of combining Chinese and Western medicine pulmonary heart disease and rheumatic heart disease mainly be adopt that infection, spasmolytic are relievingd asthma, preventing phlegm from forming and stopping coughing, expansion blood vessel, inducing diuresis to remove edema and oxygen uptake etc., but also do not succeed in developing reliable, the stable Chinese medicine preparation of a kind of curative effect, therefore need exploitation good effect, the low Chinese patent medicine preparation of side effect.
The purpose of this invention is to provide a kind of pulmonary heart disease, rheumatic heart disease and Chinese medicine preparation of the diseases such as chest pain headache due to blood stasis and the hematogenous blockage in the heart for the treatment of, select for use have heart tonifying, the Chinese medicine of the effect of activating blood circulation to dissipate blood stasis and promoting the circulation of QI to relieve pain makes effective preparation, can be used for also treating that angina pectoris, chest are dampened, diseases such as the spirit depressing of the chest pain of costal chondritis, neurosis, cerebral concussion sequela and dizziness headache.Through clinical treatment observation, find this pharmaceutical composition for pulmonary heart disease, rheumatic heart disease, angina pectoris, chest dampen, diseases such as the spirit depressing of the chest pain of costal chondritis, neurosis, cerebral concussion sequela and dizziness headache have splendid therapeutic effect, alleviate the symptom of various discomforts, do not found untoward reaction simultaneously.
Summary of the invention
The object of the present invention is to provide a kind of evident in efficacy, taking convenience, side effect little, the treatment pulmonary heart disease that can be fit to take for a long time, rheumatic heart disease and the Chinese medicinal capsule of the chest pain headache due to blood stasis and the hematogenous blockage in the heart.
The present invention also provides the preparation method of this Chinese medicinal capsule.
Pharmaceutical composition of the present invention can be used for treating pulmonary heart disease, rheumatic heart disease and the chest pain headache due to blood stasis and the hematogenous blockage in the heart, card see the vertigo, sputum stay long-pending do not loose, chest and diaphragm painful abdominal mass plug, side of body rib distension, headache are disliked contrary, the cough of panting, tears saliva is sticky, uneasy in either sitting or lying, diet are not thought, white and greasy fur and deep and stringy pulse, or liver-wind holds expectorant, vomiting and unable to take food etc. under the arm, can be used for also treating that angina pectoris, chest are dampened, diseases such as the spirit depressing of the chest pain of costal chondritis, neurosis, cerebral concussion sequela and dizziness headache.
Pharmaceutical composition of the present invention is prepared from by the following weight parts proportion raw material:
10～200 parts in 100～800 parts in Semen Persicae, 100～800 parts on Flos Carthami, 100～700 parts of Radix Angelicae Sinensis, 100～600 parts in the Radix Rehmanniae, 100～600 parts of Rhizoma Chuanxiongs, 50～500 parts of Radix Paeoniae Rubra, 50～500 parts of Radix Achyranthis Bidentataes, 50～400 parts of Radix Platycodoniss, 50～400 parts of Radix Bupleuri, 10～300 parts of Fructus Aurantii Immaturuss and Radix Glycyrrhizae.
Pharmaceutical composition of the present invention is prepared from by following preferred weight part proportion raw material:
20～100 parts in 200～500 parts in Semen Persicae, 200～500 parts on Flos Carthami, 200～400 parts of Radix Angelicae Sinensis, 200～400 parts in the Radix Rehmanniae, 200～400 parts of Rhizoma Chuanxiongs, 100～300 parts of Radix Paeoniae Rubra, 100～300 parts of Radix Achyranthis Bidentataes, 100～250 parts of Radix Platycodoniss, 100～250 parts of Radix Bupleuri, 50～200 parts of Fructus Aurantii Immaturuss and Radix Glycyrrhizae.
Pharmaceutical composition of the present invention is prepared from by following optimum weight part proportion raw material:
50 parts in 300 parts in Semen Persicae, 300 parts on Flos Carthami, 300 parts of Radix Angelicae Sinensis, 250 parts in the Radix Rehmanniae, 250 parts of Rhizoma Chuanxiongs, 200 parts of Radix Paeoniae Rubra, 200 parts of Radix Achyranthis Bidentataes, 180 parts of Radix Platycodoniss, 180 parts of Radix Bupleuri, 100 parts of Fructus Aurantii Immaturuss and Radix Glycyrrhizae.
Chinese medicinal capsule of the present invention can be prepared from by following method:
1, Semen Persicae, Radix Angelicae Sinensis, the Radix Rehmanniae and the Rhizoma Chuanxiong power with described weight portion is broken into coarser powder, and 70% alcohol dipping percolation after 48 hours leaves standstill after-filtration, gets supernatant concentration and becomes extractum 1;
2, Radix Achyranthis Bidentatae, Radix Platycodonis, Fructus Aurantii Immaturus and the Radix Glycyrrhizae powder with described weight portion is broken into coarser powder, with 80% alcohol heating reflux twice, and each each 2 hours, filter, be condensed into extractum 2;
3, after being worn into fine powder, Flos Carthami, Radix Paeoniae Rubra and the Radix Bupleuri of described weight portion decocts with water three times, and each each 2 hours, to filter, filtrate concentrates the back and merges with extractum 1 and extractum 2, divides the capsule of packing into to get final product after the spray drying.
Prescription of the present invention by Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Radix Platycodonis, Radix Bupleuri, Fructus Aurantii Immaturus and Radix Glycyrrhizae etc. ten simply Chinese medicine form.Modern pharmacological research shows: in the side is monarch drug with the Semen Persicae and Flos Carthami, and Semen Persicae can activating blood circulation to dissipate blood stasis, and relieving cough and asthma is used for multiple blood stasis and lung abscess etc.; Flos Carthami can promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing, Yong Yu lumps in the chest and abdomen, traumatic injury and the trusted subordinate diseases such as resistance pain of becoming silted up; With Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong and Radix Paeoniae Rubra is ministerial drug, and Radix Angelicae Sinensis can be enriched blood and be invigorated blood circulation, and is used for all diseases of blood deficiency; Radix Rehmanniae GUIXIN, liver, kidney channel, energy clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Rhizoma Chuanxiong energy blood-activating and qi-promoting, wind-expelling pain-stopping is used for stagnation of QI and blood; Radix Paeoniae Rubra can clearing away heat and cooling blood, and stasis-dispelling and pain-killing is used for amenorrhea stimulate the menstrual flow, lumps in the chest and abdomen and sore, carbuncle and painful swelling etc.; With Radix Achyranthis Bidentatae, Radix Platycodonis, Radix Bupleuri and Fructus Aurantii Immaturus is adjuvant drug, and Radix Achyranthis Bidentatae can promoting blood circulation to restore menstrual flow, invigorating the liver and kidney and bone and muscle strengthening, is used for deficiency of the liver and kindey, soreness of the waist and knees is unable; Radix Platycodonis can be opened lung qi dispersing gas, and the evacuation of pus of eliminating the phlegm is used for the cough with copious phlegm of inhibited pulmonary QI, the diseases such as lung abscess that freely do not reach pyretic toxicity heap soil or fertilizer over and around the roots lung uncomfortable in chest; Radix Bupleuri can evacuate bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, yang invigorating is lifted gas; The capable expectorant of Fructus Aurantii Immaturus energy dispelling the stagnated QI, dissolving lump and resolving mass can be controlled the turbid retardance of expectorant, feeling of oppression and fullness in the chest and epigastrium, the stagnation of phlegm thoracic obstruction etc.; Radix Glycyrrhizae with invigorating the spleen and benefiting QI, coordinating the actions of various ingredients in a prescription is a messenger drug, the invigorating middle warmer of Radix Glycyrrhizae energy QI invigorating, and heat-clearing and toxic substances removing, relieving spasm to stop pain, the mediation property of medicine has effects such as spleen reinforcing, lung moistening, detoxifcation, emergency and medicine.All medicine compatibilities are played the effect of activating blood circulation to dissipate blood stasis and promoting the circulation of QI to relieve pain altogether.
Pharmaceutical composition of the present invention shows through clinical experiment, we's taking convenience, side effect is little, can be fit to take for a long time, patient's taking convenience, splendid therapeutical effect is arranged, alleviated the symptom of various discomforts, can be used for treating pulmonary heart disease, rheumatic heart disease and the chest pain headache due to blood stasis and the hematogenous blockage in the heart, card is seen the vertigo, sputum stays long-pending diffusing, chest and diaphragm painful abdominal mass plug, side of body rib distension, headache is disliked contrary, the cough of panting, tears saliva is sticky, uneasy in either sitting or lying, diet is not thought, white and greasy fur and deep and stringy pulse, or liver-wind is held expectorant under the arm, vomiting and unable to take food etc. also can be used for treating angina pectoris, chest is dampened, the chest pain of costal chondritis, neurosis, diseases such as the spirit depressing of cerebral concussion sequela and dizziness headache.
Through clinical experiment, this Chinese medicinal capsule carries out observation of curative effect to 105 routine pulmonary heart disease cases, finds that total effective rate reaches 90.47%, and cure rate reaches 83.81%, therefore is with a wide range of applications.
Specific embodiment
1, Semen Persicae 100g, Flos Carthami 100g, Radix Angelicae Sinensis 100g, Radix Rehmanniae 100g, Rhizoma Chuanxiong 100g, Radix Paeoniae Rubra 100g, Radix Achyranthis Bidentatae 100g, Radix Platycodonis 100g, Radix Bupleuri 100g, Fructus Aurantii Immaturus 100g and Radix Glycyrrhizae 100g.Semen Persicae, Radix Angelicae Sinensis, the Radix Rehmanniae and the Rhizoma Chuanxiong power of described weight portion are broken into coarser powder, and 70% alcohol dipping percolation after 48 hours leaves standstill after-filtration, gets supernatant concentration and becomes extractum 1; Radix Achyranthis Bidentatae, Radix Platycodonis, Fructus Aurantii Immaturus and the Radix Glycyrrhizae powder of described weight portion are broken into coarser powder, with 80% alcohol heating reflux twice, each each 2 hours, filter, be condensed into extractum 2; The Flos Carthami of residue and described weight portion, Radix Paeoniae Rubra and Radix Bupleuri decoct with water three times after wearing into fine powder, and each each 2 hours, to filter, filtrate concentrates the back and merges with extractum 1 and extractum 2, divides the capsule of packing into to get final product after the spray drying.Every capsules contains 0.5g.Instructions of taking: every day 2 times, each 5.
2, Semen Persicae 200g, Flos Carthami 400g, Radix Angelicae Sinensis 200g, Radix Rehmanniae 300g, Rhizoma Chuanxiong 200g, Radix Paeoniae Rubra 200g, Radix Achyranthis Bidentatae 150g, Radix Platycodonis 150g, Radix Bupleuri 150g, Fructus Aurantii Immaturus 150g and Radix Glycyrrhizae 100g.Semen Persicae, Radix Angelicae Sinensis, the Radix Rehmanniae and the Rhizoma Chuanxiong power of described weight portion are broken into coarser powder, and 70% alcohol dipping percolation after 48 hours leaves standstill after-filtration, gets supernatant concentration and becomes extractum 1; Radix Achyranthis Bidentatae, Radix Platycodonis, Fructus Aurantii Immaturus and the Radix Glycyrrhizae powder of described weight portion are broken into coarser powder, with 80% alcohol heating reflux twice, each each 2 hours, filter, be condensed into extractum 2; The Flos Carthami of residue and described weight portion, Radix Paeoniae Rubra and Radix Bupleuri decoct with water three times after wearing into fine powder, and each each 2 hours, to filter, filtrate concentrates the back and merges with extractum 1 and extractum 2, divides the capsule of packing into to get final product after the spray drying.Every capsules contains 0.5g.Instructions of taking: every day 2 times, each 5.
3, Semen Persicae 300g, Flos Carthami 300g, Radix Angelicae Sinensis 300g, Radix Rehmanniae 250g, Rhizoma Chuanxiong 250g, Radix Paeoniae Rubra 200g, Radix Achyranthis Bidentatae 200g, Radix Platycodonis 180g, Radix Bupleuri 180g, Fructus Aurantii Immaturus 100g and Radix Glycyrrhizae 50g.Semen Persicae, Radix Angelicae Sinensis, the Radix Rehmanniae and the Rhizoma Chuanxiong power of described weight portion are broken into coarser powder, and 70% alcohol dipping percolation after 48 hours leaves standstill after-filtration, gets supernatant concentration and becomes extractum 1; Radix Achyranthis Bidentatae, Radix Platycodonis, Fructus Aurantii Immaturus and the Radix Glycyrrhizae powder of described weight portion are broken into coarser powder, with 80% alcohol heating reflux twice, each each 2 hours, filter, be condensed into extractum 2; The Flos Carthami of residue and described weight portion, Radix Paeoniae Rubra and Radix Bupleuri decoct with water three times after wearing into fine powder, and each each 2 hours, to filter, filtrate concentrates the back and merges with extractum 1 and extractum 2, divides the capsule of packing into to get final product after the spray drying.Every capsules contains 0.5g.Instructions of taking: every day 2 times, each 5.
Claims (4)
1. pharmaceutical composition for the treatment of pulmonary heart disease and rheumatic heart disease is characterized in that the medicine material that raw material contains following weight portion proportioning forms: 10～200 parts in 100～800 parts in Semen Persicae, 100～800 parts on Flos Carthami, 100～700 parts of Radix Angelicae Sinensis, 100～600 parts in the Radix Rehmanniae, 100～600 parts of Rhizoma Chuanxiongs, 50～500 parts of Radix Paeoniae Rubra, 50～500 parts of Radix Achyranthis Bidentataes, 50～400 parts of Radix Platycodoniss, 50～400 parts of Radix Bupleuri, 10～300 parts of Fructus Aurantii Immaturuss and Radix Glycyrrhizae.
2. require described pharmaceutical composition according to right 1, it is characterized in that the medicine material that raw material contains following preferred weight part proportioning forms: 20～100 parts in 200～500 parts in Semen Persicae, 200～500 parts on Flos Carthami, 200～400 parts of Radix Angelicae Sinensis, 200～400 parts in the Radix Rehmanniae, 200～400 parts of Rhizoma Chuanxiongs, 100～300 parts of Radix Paeoniae Rubra, 100～300 parts of Radix Achyranthis Bidentataes, 100～250 parts of Radix Platycodoniss, 100～250 parts of Radix Bupleuri, 50～200 parts of Fructus Aurantii Immaturuss and Radix Glycyrrhizae.
3. require the pharmaceutical composition of described treatment pulmonary heart disease and rheumatic heart disease according to right 1,2, it is characterized in that the optimised quantity of each raw material is: 50 parts in 300 parts in Semen Persicae, 300 parts on Flos Carthami, 300 parts of Radix Angelicae Sinensis, 250 parts in the Radix Rehmanniae, 250 parts of Rhizoma Chuanxiongs, 200 parts of Radix Paeoniae Rubra, 200 parts of Radix Achyranthis Bidentataes, 180 parts of Radix Platycodoniss, 180 parts of Radix Bupleuri, 100 parts of Fructus Aurantii Immaturuss and Radix Glycyrrhizae.
4. require described medicine according to right 3, Semen Persicae, Radix Angelicae Sinensis, the Radix Rehmanniae and the Rhizoma Chuanxiong power of described weight portion is broken into coarser powder, 70% alcohol dipping percolation after 48 hours leaves standstill after-filtration, gets supernatant concentration and becomes extractum 1; Radix Achyranthis Bidentatae, Radix Platycodonis, Fructus Aurantii Immaturus and the Radix Glycyrrhizae powder of described weight portion are broken into coarser powder, with 80% alcohol heating reflux twice, each each 2 hours, filter, be condensed into extractum 2; The Flos Carthami of residue and described weight portion, Radix Paeoniae Rubra and Radix Bupleuri decoct with water three times after wearing into fine powder, and each each 2 hours, to filter, filtrate concentrates the back and merges with extractum 1 and extractum 2, divides the capsule of packing into to get final product after the spray drying.Every capsules 0.5g.
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| CNA200810056134XA CN101229267A (en) | 2008-01-14 | 2008-01-14 | Medicine compounds for pulmonary and rheumatic heart disease and preparing method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966284A (en) * | 2010-09-29 | 2011-02-09 | 崔捷 | Medicament for treating pulmonary heart disease and preparation method thereof |
| CN102670832A (en) * | 2012-05-29 | 2012-09-19 | 王新 | Chinese medicine for treating costal chondritis |
| CN103977273A (en) * | 2014-05-15 | 2014-08-13 | 夏凯 | Drug for treating cerebral concussion sequelae |
| CN104491194A (en) * | 2014-12-07 | 2015-04-08 | 肖玉翠 | Medicine for treating cardiopulmonary stasis blocking type rheumatic heart disease and preparation method of medicine |
| CN104623549A (en) * | 2015-02-07 | 2015-05-20 | 潍坊医学院附属医院 | Traditional Chinese medicine preparation for treating costal chondritis |
| CN104758439A (en) * | 2015-03-26 | 2015-07-08 | 王浩 | Traditional Chinese medicine composition for treating thoracic obstruction |
| CN104873809A (en) * | 2015-05-26 | 2015-09-02 | 慕常松 | Traditional Chinese medicine composition for treating pulmonary heart disease |
| US11058740B2 (en) * | 2017-04-18 | 2021-07-13 | Sung Kyun Biotech Co., Ltd. | Composition for preventing, alleviating or treating stress diseases, containing Platycodon grandiflorum extract as active ingredient |
-
2008
- 2008-01-14 CN CNA200810056134XA patent/CN101229267A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966284A (en) * | 2010-09-29 | 2011-02-09 | 崔捷 | Medicament for treating pulmonary heart disease and preparation method thereof |
| CN102670832A (en) * | 2012-05-29 | 2012-09-19 | 王新 | Chinese medicine for treating costal chondritis |
| CN103977273A (en) * | 2014-05-15 | 2014-08-13 | 夏凯 | Drug for treating cerebral concussion sequelae |
| CN104491194A (en) * | 2014-12-07 | 2015-04-08 | 肖玉翠 | Medicine for treating cardiopulmonary stasis blocking type rheumatic heart disease and preparation method of medicine |
| CN104623549A (en) * | 2015-02-07 | 2015-05-20 | 潍坊医学院附属医院 | Traditional Chinese medicine preparation for treating costal chondritis |
| CN104758439A (en) * | 2015-03-26 | 2015-07-08 | 王浩 | Traditional Chinese medicine composition for treating thoracic obstruction |
| CN104873809A (en) * | 2015-05-26 | 2015-09-02 | 慕常松 | Traditional Chinese medicine composition for treating pulmonary heart disease |
| US11058740B2 (en) * | 2017-04-18 | 2021-07-13 | Sung Kyun Biotech Co., Ltd. | Composition for preventing, alleviating or treating stress diseases, containing Platycodon grandiflorum extract as active ingredient |
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Open date: 20080730 |