CN101195559B - Process for producing resveratrol nano-crystallization and uses thereof - Google Patents
Process for producing resveratrol nano-crystallization and uses thereof Download PDFInfo
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- CN101195559B CN101195559B CN2007101885939A CN200710188593A CN101195559B CN 101195559 B CN101195559 B CN 101195559B CN 2007101885939 A CN2007101885939 A CN 2007101885939A CN 200710188593 A CN200710188593 A CN 200710188593A CN 101195559 B CN101195559 B CN 101195559B
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- 238000000034 method Methods 0.000 title claims abstract description 11
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 title claims description 70
- 230000008569 process Effects 0.000 title claims description 8
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 title description 5
- 235000021283 resveratrol Nutrition 0.000 title description 5
- 229940016667 resveratrol Drugs 0.000 title description 5
- 238000007709 nanocrystallization Methods 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000018991 trans-resveratrol Nutrition 0.000 claims description 65
- 239000002159 nanocrystal Substances 0.000 claims description 30
- 238000002360 preparation method Methods 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000000243 solution Substances 0.000 claims description 15
- 235000021355 Stearic acid Nutrition 0.000 claims description 12
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 12
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 12
- 239000008117 stearic acid Substances 0.000 claims description 12
- 238000002425 crystallisation Methods 0.000 claims description 11
- 230000008025 crystallization Effects 0.000 claims description 10
- 239000012065 filter cake Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- 238000000967 suction filtration Methods 0.000 claims description 10
- 239000006071 cream Substances 0.000 claims description 7
- 238000002386 leaching Methods 0.000 claims description 5
- 230000010355 oscillation Effects 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 239000012047 saturated solution Substances 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 2
- 239000005639 Lauric acid Substances 0.000 claims description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 2
- 239000005642 Oleic acid Substances 0.000 claims description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 2
- 229960004232 linoleic acid Drugs 0.000 claims description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 20
- 239000002537 cosmetic Substances 0.000 abstract description 12
- 239000002994 raw material Substances 0.000 abstract description 8
- 239000013078 crystal Substances 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 4
- 230000009471 action Effects 0.000 abstract description 2
- 230000003796 beauty Effects 0.000 abstract description 2
- 240000006122 Chenopodium album Species 0.000 abstract 4
- 235000009344 Chenopodium album Nutrition 0.000 abstract 4
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000000516 sunscreening agent Substances 0.000 description 11
- 230000005855 radiation Effects 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 238000000586 desensitisation Methods 0.000 description 4
- 230000002519 immonomodulatory effect Effects 0.000 description 4
- 239000002502 liposome Substances 0.000 description 4
- 230000000475 sunscreen effect Effects 0.000 description 4
- 206010002198 Anaphylactic reaction Diseases 0.000 description 3
- 208000003455 anaphylaxis Diseases 0.000 description 3
- 230000003260 anti-sepsis Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 238000003908 quality control method Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 239000011787 zinc oxide Substances 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000002605 anti-dotal effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000004223 radioprotective effect Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
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Abstract
The invention relates to the beauty skin-care cosmetic technical field, specifically relates to a method for preparing white chenopodium album alcohol nanometer crystal and application, wherein the water-solubility of white chenopodium album alcohol is bad, biological utility is low and seriously influences wide application in each field. Therefore, the invention provides a method for preparing white chenopodium album alcohol nanometer crystal which is provided with better stability, higher utility and water-solubility, which not only results in effective component of extract dissolve completely, saves raw material greatly, but also is provided with little extract usage, fast adsorption, high utility, good action effect, little side effect and convenient to use. The invention provides white chenopodium album alcohol nanometer crystal that completely overcomes the insufficiency of the prior nanometer cosmetics, which has a plurality of advantages in the cosmetics when using.
Description
Technical field
The present invention relates to beauty and skin care makeup technical field, be specifically related to a kind of preparation method and application thereof of trans-resveratrol nanocrystal.
Background technology
Trans-resveratrol is the main raw material of medicine, chemical industry, food, makeup aspect.It is found that it has multiple pharmacologically active, comprise anti-oxidant activity, platelet aggregation-against, atherosclerosis, anti-inflammatory, estrogenic activity, growth inhibitory activity, immunomodulatory and chemoprophylaxis effect etc.
The application resveratrol molecule structure of trans-resveratrol on makeup has catches free radical, anti-oxidant, the characteristic that absorbs UV-light, shows remarkable effect aspect makeup, is a kind of good natural antioxidants.Generally speaking, antioxidant is used in mainly plays the part of the anti-oxidant role of skin in the makeup, skin is delayed senility.In addition, trans-resveratrol can also promote vasodilation effectively, has anti-inflammatory, sterilization and moisture-keeping function, is fit to dispel acne, bag rash, wrinkle etc., can be used for preserving moisture, late frost, skin moisten class makeup.
But because the poorly water-soluble of trans-resveratrol, bioavailability is low, has had a strong impact on its widespread use in every field.Therefore, seek and research is gentle, toxic side effect is little formulation is improved the water-soluble of trans-resveratrol, and improve its bioavailability and have very important significance.
The big gordian technique of its manufacturing technology of the application of trans-resveratrol on makeup is: the speed of growth of one, artificially controlling resveratrol recrystallized nuclear is to nano level; Two, in the rotary evaporation process, under natural cooling condition, carry out ultrasonicly, it well is scattered among the water; Be meant liposome for above-mentioned common practice.
Yet because liposome belongs to unsettled emulsification system, it is a lot of to influence its stability factor, wherein the HLB value of other materials in ionic strength, the system, hybrid mode etc. all may influence liposome stablizing in system, therefore are not supported in the cream frost system to add nanometer liposome.Improve its stability and improve its water-soluble prerequisite that is preparation high quality cosmetic product with trans-resveratrol.
Summary of the invention
The object of the present invention is to provide a kind of better stability and than the preparation method of the water miscible trans-resveratrol nanocrystal of high utilization rate.
Another object of the present invention is to provide the application of trans-resveratrol nanocrystal in cosmetics.
In order to achieve the above object, technical scheme of the present invention is:
A kind of preparation method of trans-resveratrol nanocrystal, its special character is: preparation process is as follows:
(1) under reflux, makes the spirituous solution that contains stearic acid 1--8% with alcohol and stearic acid, be solution A;
(2) in A, add trans-resveratrol powder (content 98%), under the backflow situation, make the trans-resveratrol saturated solution, be solution B by amount;
(3) B is changed immediately over to (power 250W, frequency 33kHz) in the ultrasonic oscillation device, lower the temperature naturally, constantly have crystallization to separate out in the temperature-fall period in the ultransonic while; This process is performed until temperature 15-25 degree, and the later stage cools off with frozen water;
(4) after the ultrasonic end, carry out suction filtration, and the pure water washing leaching cake of doubly measuring with the 1-2 of A; When suction filtration begins, a large amount of leakage material are arranged, treat that filter cake forms and compacting after, just do not have crystallization and spill;
(5) the gained filter cake adds a small amount of pure water and makes into paste, is nano level trans-resveratrol cream.
Stearic acid in the above-mentioned steps (1) also can be lauric acid, palmitinic acid, linolic acid, oleic acid or synthetic fatty acid and substitutes.
The application of trans-resveratrol nanocrystal in cosmetics, this trans-resveratrol nanocrystal has crease-resistant, antidotal effect; This trans-resveratrol nanocrystal has immunomodulatory, antisepsis and anti-inflammation and anti-anaphylaxis desensitization; This trans-resveratrol nanocrystal has radioprotective, resists the effect of all-wave UV-light.
The invention has the beneficial effects as follows: a kind of new way of processing Chinese medical extract is provided, can makes the abundant stripping of extract effective constituent, a large amount of conservations; Can make the extract consumption little again, absorb soon, the availability height, action effect is good, and side effect is little, and is easy to use.
Nanocrystal trans-resveratrol provided by the invention makes trans-resveratrol in crystallisation process, controls the growth of trans-resveratrol crystalline with distinctive preparation method, and crystallographic dimension is just stopped growing with interior in 100 nanometers; So just obtained the trans-resveratrol crystal of diameter between 10～100 nanometers.The trans-resveratrol nanocrystal has overcome the deficiency of present nm cosmetic fully, uses it that a lot of advantages are arranged in makeup.
Description of drawings
Fig. 1 is the trans-resveratrol nano junction crystal under the electron microscope.
Embodiment
The present invention is described in detail below in conjunction with specific embodiment.
Embodiment 1:
A kind of preparation method of trans-resveratrol nanocrystal, preparation process is as follows:
(1) under reflux, makes the spirituous solution that contains stearic acid 2% with alcohol and stearic acid, be solution A;
(2) in A, pursue the trans-resveratrol powder of measuring adding content 98%, under the backflow situation, make the trans-resveratrol saturated solution, be solution B;
(3) change B over to power 250W immediately, in the ultrasonic oscillation device of frequency 33kHz, lower the temperature naturally, constantly have crystallization to separate out in the temperature-fall period in the ultransonic while; This process is performed until temperature 15 degree, and the later stage cools off with frozen water;
(4) after the ultrasonic end, carry out suction filtration, and with the pure water washing leaching cake of 1 times of amount of A; When suction filtration begins, a large amount of leakage material are arranged, treat that filter cake forms and compacting after, just do not have crystallization and spill;
(5) the gained filter cake adds a small amount of pure water and makes into paste, is nano level trans-resveratrol cream.
Embodiment 2:
A kind of preparation method of trans-resveratrol nanocrystal, preparation process is as follows:
(1) under reflux, makes the spirituous solution that contains stearic acid 7% with alcohol and stearic acid, be solution A;
(2) in A, pursue the trans-resveratrol powder of measuring adding content 98%, under the backflow situation, make the trans-resveratrol saturated solution, be solution B;
(3) change B over to power 250W immediately, in the ultrasonic oscillation device of frequency 33kHz, lower the temperature naturally, constantly have crystallization to separate out in the temperature-fall period in the ultransonic while; This process is performed until temperature 25 degree, and the later stage cools off with frozen water;
(4) after the ultrasonic end, carry out suction filtration, and with the pure water washing leaching cake of 2 times of amounts of A; When suction filtration begins, a large amount of leakage material are arranged, treat that filter cake forms and compacting after, just do not have crystallization and spill;
(5) the gained filter cake adds a small amount of pure water and makes into paste, is nano level trans-resveratrol cream.
Embodiment 3:
A kind of preparation method of trans-resveratrol nanocrystal, preparation process is as follows:
(1) under reflux, makes the spirituous solution that contains stearic acid 5% with alcohol and stearic acid, be solution A;
(2) in A, pursue the trans-resveratrol powder of measuring adding content 98%, under the backflow situation, make the trans-resveratrol saturated solution, be solution B;
(3) change B over to power 250W immediately, in the ultrasonic oscillation device of frequency 33kHz, lower the temperature naturally, constantly have crystallization to separate out in the temperature-fall period in the ultransonic while; This process is performed until temperature 20 degree, and the later stage cools off with frozen water;
(4) after the ultrasonic end, carry out suction filtration, and with the pure water washing leaching cake of 1.5 times of amounts of A; When suction filtration begins, a large amount of leakage material are arranged, treat that filter cake forms and compacting after, just do not have crystallization and spill;
(5) the gained filter cake adds a small amount of pure water and makes into paste, is nano level trans-resveratrol cream.The application of nanometer resveratrol recrystallized in cosmetics:
1, the application in crease-resistant:
Trans-resveratrol nanocrystal homogeneous is dispersed in the skin care product, can be absorbed sustainedly and stably, can make it reach the inaccessible effect of conventional makeup by skin; And the unstable of trans-resveratrol is thoroughly improved, can make the trans-resveratrol that is added in the makeup keep fresh and alive and stable.We adopt the trans-resveratrol nanocrystal of independent research, make crease-resistant, anti-ageing type makeup, through the experiment on probation of 183 examples, prove that this class cosmetic formulations is stable, and the effective active components shelf time is of a specified duration, and effect is fairly obvious; Efficient 89.8%.
2, the application in desensitization
Nanoparticle is used also very extensive on antibiotic sterile material, and it can disturb the synthetic of bacterioprotein, thereby suppresses the breeding of bacterium effectively.This quality control for makeup provides new thinking.Can in cosmetic product, reduce or, significantly reduce the allergic untoward reaction of Denging without antiseptic-germicide, sanitas.Self has bacteriostatic action nanometer materials, in addition the antibacterial and anti-inflammation functions of trans-resveratrol itself.Added the makeup of trans-resveratrol nanocrystal, skin has been had good immunomodulatory, antisepsis and anti-inflammation and anti-anaphylaxis desensitization.
3, the application in sun-proof
In sun care preparations, titanium dioxide and zinc oxide all are good UV light absorber.But their side effect has limited their use.And the trans-resveratrol nanocrystal is used in the makeup sun-screening agent, and biggest advantage is that it belongs to the organic active raw material, and not resembling inorganic sunscreen has than strong and stimulating, and skin is produced toxic side effect.Use as safe as a house.In addition, in traditional prescription, behind the use sun-screening agent raw material, can produce white residue, and use the sunscreen noresidue of trans-resveratrol nanocrystal raw material.And it is also very strong to intercept ultraviolet function.Trans-resveratrol itself has very strong radiation resistance in addition, also is a kind of uvioresistant sun-screening agent of superior performance.Nanocrystal can resist long wave and ultraviolet B radiation, and trans-resveratrol can be resisted ultraviolet B radiation, and their synergies just can be resisted the all-wave UV-light ideally.Make sun-proof effect multiplication.
The effect of nanometer resveratrol recrystallized in makeup:
A, trans-resveratrol utilization ratio and effect are significantly improved
Trans-resveratrol nanocrystal homogeneous is dispersed in the skin care product, can be absorbed sustainedly and stably, can make it reach the inaccessible effect of conventional makeup by skin; And the unstable of trans-resveratrol is thoroughly improved, can make the trans-resveratrol that is added in the makeup keep fresh and alive and stable.We adopt the trans-resveratrol nanocrystal of independent research, make crease-resistant, anti-ageing type makeup, through the experiment on probation of 183 examples, prove that this class cosmetic formulations is stable, and the effective active components shelf time is of a specified duration, and effect is fairly obvious; Efficient 89.8%.
B, anti-microbial effect are distinguished
Nanoparticle is used also very extensive on antibiotic sterile material, and it can disturb the synthetic of bacterioprotein, thereby suppresses the breeding of bacterium effectively.This quality control for makeup provides new thinking.Can in cosmetic product, reduce or, significantly reduce the allergic untoward reaction of Denging without antiseptic-germicide, sanitas.Self has bacteriostatic action nanometer materials, in addition the antibacterial and anti-inflammation functions of trans-resveratrol itself.Added the makeup of trans-resveratrol nanocrystal, skin has been had good immunomodulatory, antisepsis and anti-inflammation and anti-anaphylaxis desensitization.
C, the multiplication of sun-screening agent function
In sun care preparations, titanium dioxide and zinc oxide all are good UV light absorber.But their side effect has limited their use.And the trans-resveratrol nanocrystal is used in the makeup sun-screening agent, and biggest advantage is that it belongs to the organic active raw material, and not resembling inorganic sunscreen has than strong and stimulating, and skin is produced toxic side effect.Use as safe as a house.In addition, in traditional prescription, behind the use sun-screening agent raw material, can produce white residue, and use the sunscreen noresidue of trans-resveratrol nanocrystal raw material.And it is also very strong to intercept ultraviolet function.Trans-resveratrol itself has very strong radiation resistance in addition, also is a kind of uvioresistant sun-screening agent of superior performance.Nanocrystal can resist long wave and ultraviolet B radiation, and trans-resveratrol can be resisted ultraviolet B radiation, and their synergies just can be resisted the all-wave UV-light ideally.Make sun-proof effect multiplication.
D, easy to use
Because trans-resveratrol is the water insoluble oil that also is insoluble to, this makes it use very big difficulty in makeup.And the trans-resveratrol nanocrystal can be easy to even matter and is dispersed in aqueous phase, thus on preparation easily.Nanocrystal can be suspended in the preparations such as frost, cream, breast or gel to stable and uniform.But it is not suitable for disguising water, because it can precipitate in water gradually.
Claims (2)
1. the preparation method of a trans-resveratrol nanocrystal, it is characterized in that: preparation process is as follows:
(1) under reflux, makes the spirituous solution that contains stearic acid 1--8% with alcohol and stearic acid, be solution A;
(2) adding content by amount in A is 98% trans-resveratrol powder, makes the trans-resveratrol saturated solution under the backflow situation, is solution B;
(3) B is changed over to immediately in the ultrasonic oscillation device of power 250W, frequency 33kHz, lower the temperature naturally, constantly have crystallization to separate out in the temperature-fall period in the ultransonic while; This process is performed until temperature 15-25 degree, and the later stage cools off with frozen water;
(4) after the ultrasonic end, carry out suction filtration, and the pure water washing leaching cake of doubly measuring with the 1-2 of A; When suction filtration begins, a large amount of leakage material are arranged, treat that filter cake forms and compacting after, just do not have crystallization and spill;
(5) the gained filter cake adds a small amount of pure water and makes into paste, is nano level trans-resveratrol cream.
2. the preparation method of trans-resveratrol nanocrystal according to claim 1 is characterized in that: the stearic acid in the described step (1) adopts lauric acid, palmitinic acid, linolic acid or oleic acid to replace.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007101885939A CN101195559B (en) | 2007-12-12 | 2007-12-12 | Process for producing resveratrol nano-crystallization and uses thereof |
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| CN2007101885939A CN101195559B (en) | 2007-12-12 | 2007-12-12 | Process for producing resveratrol nano-crystallization and uses thereof |
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| CN101195559B true CN101195559B (en) | 2011-04-06 |
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| CN102125537A (en) * | 2010-12-07 | 2011-07-20 | 沈阳药科大学 | Novel medical application of resveratrol and derivatives thereof |
| CN108514539B (en) * | 2018-07-11 | 2021-07-27 | 广州市腾宇化妆品有限公司 | Antiseptic composition for cosmetics based on mild effect and preparation method of cosmetics |
| CN113509421A (en) * | 2021-08-19 | 2021-10-19 | 河南科技大学 | Peony seed shell cosmetic sunscreen raw material and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1621401A (en) * | 2003-11-28 | 2005-06-01 | 张�浩 | Method for extracting high purity resveratrol from giant knotweed rhizome |
| CN1760166A (en) * | 2005-11-11 | 2006-04-19 | 余淑娴 | New method for picking-up purified resveratrol from giant knotweed |
| CN1896255A (en) * | 2006-06-17 | 2007-01-17 | 曹庸 | Extraction of high-purity resveratrol by converting microbion into polydatin material |
-
2007
- 2007-12-12 CN CN2007101885939A patent/CN101195559B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1621401A (en) * | 2003-11-28 | 2005-06-01 | 张�浩 | Method for extracting high purity resveratrol from giant knotweed rhizome |
| CN1760166A (en) * | 2005-11-11 | 2006-04-19 | 余淑娴 | New method for picking-up purified resveratrol from giant knotweed |
| CN1896255A (en) * | 2006-06-17 | 2007-01-17 | 曹庸 | Extraction of high-purity resveratrol by converting microbion into polydatin material |
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