CN101195559B - Process for producing resveratrol nano-crystallization and uses thereof - Google Patents
Process for producing resveratrol nano-crystallization and uses thereof Download PDFInfo
- Publication number
- CN101195559B CN101195559B CN2007101885939A CN200710188593A CN101195559B CN 101195559 B CN101195559 B CN 101195559B CN 2007101885939 A CN2007101885939 A CN 2007101885939A CN 200710188593 A CN200710188593 A CN 200710188593A CN 101195559 B CN101195559 B CN 101195559B
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- CN
- China
- Prior art keywords
- resveratrol
- trans
- nanocrystal
- acid
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 title claims abstract description 11
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 title claims description 70
- 230000008569 process Effects 0.000 title claims description 8
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 title description 5
- 235000021283 resveratrol Nutrition 0.000 title description 5
- 229940016667 resveratrol Drugs 0.000 title description 5
- 238000007709 nanocrystallization Methods 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000018991 trans-resveratrol Nutrition 0.000 claims description 65
- 239000002159 nanocrystal Substances 0.000 claims description 30
- 238000002360 preparation method Methods 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000000243 solution Substances 0.000 claims description 15
- 235000021355 Stearic acid Nutrition 0.000 claims description 12
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 12
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 12
- 239000008117 stearic acid Substances 0.000 claims description 12
- 238000002425 crystallisation Methods 0.000 claims description 11
- 230000008025 crystallization Effects 0.000 claims description 10
- 239000012065 filter cake Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- 238000000967 suction filtration Methods 0.000 claims description 10
- 239000006071 cream Substances 0.000 claims description 7
- 238000002386 leaching Methods 0.000 claims description 5
- 230000010355 oscillation Effects 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 239000012047 saturated solution Substances 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 2
- 239000005639 Lauric acid Substances 0.000 claims description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 2
- 239000005642 Oleic acid Substances 0.000 claims description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 2
- 229960004232 linoleic acid Drugs 0.000 claims description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 20
- 239000002537 cosmetic Substances 0.000 abstract description 12
- 239000002994 raw material Substances 0.000 abstract description 8
- 239000013078 crystal Substances 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 4
- 230000009471 action Effects 0.000 abstract description 2
- 230000003796 beauty Effects 0.000 abstract description 2
- 240000006122 Chenopodium album Species 0.000 abstract 4
- 235000009344 Chenopodium album Nutrition 0.000 abstract 4
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000000516 sunscreening agent Substances 0.000 description 11
- 230000005855 radiation Effects 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 238000000586 desensitisation Methods 0.000 description 4
- 230000002519 immonomodulatory effect Effects 0.000 description 4
- 239000002502 liposome Substances 0.000 description 4
- 230000000475 sunscreen effect Effects 0.000 description 4
- 206010002198 Anaphylactic reaction Diseases 0.000 description 3
- 208000003455 anaphylaxis Diseases 0.000 description 3
- 230000003260 anti-sepsis Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 238000003908 quality control method Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 239000011787 zinc oxide Substances 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000002605 anti-dotal effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000004223 radioprotective effect Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
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Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007101885939A CN101195559B (en) | 2007-12-12 | 2007-12-12 | Process for producing resveratrol nano-crystallization and uses thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007101885939A CN101195559B (en) | 2007-12-12 | 2007-12-12 | Process for producing resveratrol nano-crystallization and uses thereof |
Publications (2)
Publication Number | Publication Date |
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CN101195559A CN101195559A (en) | 2008-06-11 |
CN101195559B true CN101195559B (en) | 2011-04-06 |
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CN2007101885939A Active CN101195559B (en) | 2007-12-12 | 2007-12-12 | Process for producing resveratrol nano-crystallization and uses thereof |
Country Status (1)
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CN (1) | CN101195559B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102125537A (en) * | 2010-12-07 | 2011-07-20 | 沈阳药科大学 | Novel medical application of resveratrol and derivatives thereof |
CN108514539B (en) * | 2018-07-11 | 2021-07-27 | 广州市腾宇化妆品有限公司 | Antiseptic composition for cosmetics based on mild effect and preparation method of cosmetics |
CN113509421A (en) * | 2021-08-19 | 2021-10-19 | 河南科技大学 | Peony seed shell cosmetic sunscreen raw material and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1621401A (en) * | 2003-11-28 | 2005-06-01 | 张�浩 | Method for extracting high purity resveratrol from giant knotweed rhizome |
CN1760166A (en) * | 2005-11-11 | 2006-04-19 | 余淑娴 | New method for picking-up purified resveratrol from giant knotweed |
CN1896255A (en) * | 2006-06-17 | 2007-01-17 | 曹庸 | Extraction of high-purity resveratrol by converting microbion into polydatin material |
-
2007
- 2007-12-12 CN CN2007101885939A patent/CN101195559B/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1621401A (en) * | 2003-11-28 | 2005-06-01 | 张�浩 | Method for extracting high purity resveratrol from giant knotweed rhizome |
CN1760166A (en) * | 2005-11-11 | 2006-04-19 | 余淑娴 | New method for picking-up purified resveratrol from giant knotweed |
CN1896255A (en) * | 2006-06-17 | 2007-01-17 | 曹庸 | Extraction of high-purity resveratrol by converting microbion into polydatin material |
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Publication number | Publication date |
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CN101195559A (en) | 2008-06-11 |
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GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Xi'an Tianxing Jian natural biological products Co., Ltd. Assignor: Wang Yun Contract record no.: 2012610000100 Denomination of invention: Process for producing resveratrol nano-crystallization and uses thereof Granted publication date: 20110406 License type: Exclusive License Open date: 20080611 Record date: 20120608 |
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TR01 | Transfer of patent right |
Effective date of registration: 20171123 Address after: 710075 1 unit 1, unit 1030, room 5, Rong Xin Road, Xi'an high tech Zone, Shaanxi Patentee after: Xi'an Tianxing Jian natural biological products Co., Ltd. Address before: No. 5, Hsin Xin Road, Xi'an high tech Zone, Shaanxi Province Patentee before: Wang Yun |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Process for producing resveratrol nano-crystallization and uses thereof Effective date of registration: 20180211 Granted publication date: 20110406 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: Xi'an Tianxing Jian natural biological products Co., Ltd. Registration number: 2018990000141 |
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Date of cancellation: 20181207 Granted publication date: 20110406 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: Xi'an Tianxing Jian natural biological products Co., Ltd. Registration number: 2018990000141 |
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Denomination of invention: Process for producing resveratrol nano-crystallization and uses thereof Effective date of registration: 20191227 Granted publication date: 20110406 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: Xi'an Tianxing Jian natural biological products Co., Ltd. Registration number: Y2019990000811 |
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Date of cancellation: 20201208 Granted publication date: 20110406 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: Xi'an Tianxing Jian natural biological products Co.,Ltd. Registration number: Y2019990000811 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right |