CN101152310A - Traditional Chinese medicine liquid capsule and its preparing method - Google Patents
Traditional Chinese medicine liquid capsule and its preparing method Download PDFInfo
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Abstract
The invention discloses a liquid capsule of traditional Chinese medicine for remedying the inappetence, the nausea and vomitus, the abdominal flatulence and diarrhea and the dyspepsia and the preparation method of the liquid capsule. Catechu uncaria, corktree bark, liquorice, tangerine peel and cassia bark are decocted by water, and filtrate is condensed as thick ointment; run oil is added into the thick ointment to be mixed uniformly for obtaining a traditional Chinese medicine combination; the liquid capsule is prepared by adding the officinal auxiliary materials with the pharmic acceptable quantity into the traditional Chinese medicine combination. The liquid capsule of traditional Chinese medicine which is prepared by the invention has the advantages of simple technology, good curative effect and being convenient for taking and can be used for remedying the symptoms of inappetence, the nausea and vomitus, the abdominal flatulence and diarrhea, the dyspepsia etc.
Description
Technical field
The present invention relates to a kind of inappetence, nausea and vomiting, abdominal distention diarrhoea, dyspeptic herb liquid body capsule of being used for the treatment of, be specifically related to a kind of adult that unhygienic diet or being not acclimatized cause and herb liquid body capsule of infantile diarrhea of being used for the treatment of, the present invention also relates to the preparation method of this herb liquid body capsule.
Background technology
The diarrhoea that unhygienic diet or being not acclimatized cause, stomachache are because people's body reacts a kind of imbalance of conditions such as new weather, physical features, water quality, food.Infantile diarrhea is one group to be increased by many cause of diseases, the multifactor times of defecation that causes and the character of defecating is changed into the usual diseases of childhood of characteristics.Can be divided into infectious and non-infectious two kinds.Onset can be delayed can be anxious, and light disease only has gastrointestinal symptom, inappetence, and idol has vomiting, times of defecation to increase and character changes; Heavy person's times of defecation will reach surplus one day ten time, even tens times, stool can be water sample, pasty state, mucus shape, and significantly dehydration and electrolyte disturbance and whole body poisoning symptom such as hyperpyrexia, agitation, lethargy etc. can appear simultaneously in the bloody purulent stool separated that has.The most onset of infantile diarrhea is very anxious, and frequent diarrhoea can make intravital moisture and nutrient lose rapidly, causes acute dehydration.Generally be to take that symptom does not take a turn for the better after the oral rehydration, lethargy, fever, frequent vomiting, water sample stool occur, even have pus and blood just, should remove hospital admission immediately, but continuous supplementary oral liquor body on the way.
The normal clinical commonly used drug of adult that unhygienic diet or being not acclimatized cause and infantile diarrhea is HUOXIANG ZHENGQI WAN/water and infection and digestant such as berberine, but HUOXIANG ZHENGQI WAN/water and berberine have the strong impulse abnormal smells from the patient, are difficult for the particularly child patient acceptance for the patient.
Summary of the invention
The herb liquid body capsule that the purpose of this invention is to provide a kind of effective treatment inappetence that can be easy to accept by the patient, nausea and vomiting, abdominal distention diarrhoea, indigestion symptom.
Another object of the present invention provides a kind of method for preparing above-mentioned herb liquid body capsule.
For achieving the above object, the inventor designs through a large amount of experiment and performing creative labour on the basis of existing technology and is used for the treatment of inappetence, nausea and vomiting, abdominal distention diarrhoea, dyspeptic herb liquid body capsule, comprise softgel shell and capsule liquid, described capsule liquid comprises following components by part by weight:
Chinese medicine composition 6-15 dispersant 12-16 suspending agent 0.4～0.7;
Described Chinese medicine composition is formed by the following components in part by weight processing and preparing:
Heat up in a steamer oily 20-60 Uncaria gambier Roxb. 30-200 Cortex Phellodendri 10-60
Radix Glycyrrhizae 8-35 Pericarpium Citri Reticulatae 15-50 Cortex cinnamomi japonici (Ramulus Cinnamomi) 30-70.
Preferably, described Chinese medicine composition is formed through processing and preparing by following parts by weight of Chinese traditional medicine raw material:
Heat up in a steamer oily 30-50 Uncaria gambier Roxb. 50-150 Cortex Phellodendri 15-30
Radix Glycyrrhizae 10-30 Pericarpium Citri Reticulatae 20-40 Cortex cinnamomi japonici (Ramulus Cinnamomi) 40-60.
Most preferably, described Chinese medicine composition is formed through processing and preparing by following parts by weight of Chinese traditional medicine raw material:
Heat up in a steamer oily 35-45 Uncaria gambier Roxb. 75-120 Cortex Phellodendri 30-40
Radix Glycyrrhizae 15-20 Pericarpium Citri Reticulatae 30-40 Cortex cinnamomi japonici (Ramulus Cinnamomi) 40-60.
The described oil that heats up in a steamer is creosote, pine tar or bamboo tar.
Described dispersant is polyethylene glycols or vegetable oil; Described suspending agent is one or more the mixture in Cera Flava, lecithin, aluminum monostearate, ethyl cellulose, the propylene glycol.
Described vegetable oil is a kind of or wherein several mixture of Oleum Arachidis hypogaeae semen, soybean oil, Oleum sesami, Oleum Brassicae campestris or other consumption vegetable oil.
The antiseptic and/or the surfactant that contain convention amount in the described capsule liquid.
Described antiseptic is parabens or glycerol monostearate; Described surface activity reaches and is tween or span.
A kind of method for preparing above-mentioned herb liquid body capsule comprises the steps:
Uncaria gambier Roxb., Cortex Phellodendri, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Cortex cinnamomi japonici (Ramulus Cinnamomi) are decocted with water 2-3 time, and each 1-3 hour, collecting decoction filtered, and surveying relative density when filtrate is condensed into 60 ℃ is the thick paste of 1.10-1.30; Wherein amount of water be Uncaria gambier Roxb., Cortex Phellodendri, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Cortex cinnamomi japonici (Ramulus Cinnamomi) gross weight 6-10 doubly; To heat up in a steamer oil and join in the thick paste, and stir, and get Chinese medicine composition, and add dispersant and suspending agent, colloid mill is ground to mix homogeneously, gets capsule liquid, and filling is prepared into liquid capsule in the capsule softgel shell.
The method of the above-mentioned herb liquid body capsule of another kind of preparation comprises the steps:
1. getting Cortex Phellodendri is 60～90% alcohol heating reflux 2～3 times in percent by volume, each 1～3 hour, filter, and merging filtrate, filtrate recycling ethanol extremely do not have the alcohol flavor, filter, and get filtrate A; Or,
Cortex Phellodendri is processed into coarse powder, and doubly measuring saturated limewater with 8-12 is solvent, supersound extraction 2-3 time, 15-30min/ time, extracting solution is mixed with the solution of counting 30-35mg/ml with crude drug, filters, add the NaCl placement and spend the night, filter, oven dry is dissolved in water in precipitation, filters, and it is 1～2 that filtrate adds hydrochloric acid accent pH, treat that post precipitation filters, and gets filtrate A;
2. Uncaria gambier Roxb., Radix Glycyrrhizae, Pericarpium Citri Reticulatae and Cortex cinnamomi japonici (Ramulus Cinnamomi) are decocted with water 2～3 times, each 1～3 hour, collecting decoction filtered, and the survey relative density was 1.10～1.30 extractum B when filtrate was concentrated into 60 ℃; Wherein amount of water is Uncaria gambier Roxb., Radix Glycyrrhizae, Pericarpium Citri Reticulatae and Cortex cinnamomi japonici (Ramulus Cinnamomi) gross weight 6～10 times;
3. filtrate A is mixed with extractum B, relative density is 1.10～1.30 extractum when being concentrated into 60 ℃, and drying is made fine powder, add and heat up in a steamer oil, stir, get Chinese medicine composition, add dispersant and suspending agent, colloid mill is ground to mix homogeneously, get capsule liquid, filling is prepared into liquid capsule in the capsule softgel shell.
The described oil that heats up in a steamer is with Fagaceae plant Fagus sinensis Oliv. Fagus sinensis Oliv., natural beech section natural plant Zelkova schneideriana Hand.-Mazz., maple, Xylosmae japonici, Quercus acutissima Carr., Pinaceae pinaceae Pinus pinus plant pinaster or Juniperus rigida Sieb.et Zucc., bamboo places distillating still to distill, getting dry distillation liquid distills under 180-360 ℃ of condition, the fraction that collection is heavier than water, handle as follows:
1. add the aqueous slkali that percentage by weight is 5-20%, stir crystallisation by cooling;
2. filter, discard filtrate, the washing of filtering residue clear water discards washings, adding weight percent concentration is the 20-35% sulfuric acid solution, stirs, and discards sulfate wastewater, clear water washing back is rectification under vacuum under the 0.08-0.09MPa condition in vacuum, collects 130-155 ℃ rectification branch, promptly;
Described fraction: aqueous slkali: the weight part ratio of sulfuric acid solution is 1-3: 2-4: 2-3.5.
Add calcium acetate or magnesium acetate solution that percentage by weight is 10-30% after 1. described step stirs again; Described fraction: the weight part ratio of calcium acetate or magnesium acetate is 1-3: 4-7.
Described step aqueous slkali 1. is sodium hydroxide or potassium hydroxide solution.
Described Fagaceae plant Fagus sinensis Oliv. Fagus sinensis Oliv., natural beech section natural plant Zelkova schneideriana Hand.-Mazz., maple, Xylosmae japonici, Quercus acutissima Carr., Pinaceae pinaceae Pinus pinus plant pinaster or Juniperus rigida Sieb.et Zucc., bamboo places distillating still to distill, getting dry distillation liquid distills under 180-360 ℃ of condition, the collection fraction heavier than water places rectifying still, in temperature is 130-155 ℃, withdrawing moisture and light fraction under the vacuum 0.08-0.09MPa condition, with the freezing 12-48 hour crystallization under subzero 20 to 0 ℃ of conditions of the fraction in the rectifying still, the crystal centrifugalize obtains heating up in a steamer oily crystal.
Also add antiseptic and/or surfactant in the described capsule liquid.
The Chinese medicine composition of herb liquid body capsule of the present invention is that the inventor preferably comes out from crude drug through a large amount of tests, and having stagnation is rushed down, and is used for adult and infantile diarrhea that eating and drinking without temperance or being not acclimatized cause, belongs to damp and hot, dyspepsia card person.Card is seen: inappetence, nausea and vomiting, abdominal distention diarrhoea, dyspepsia.Heating up in a steamer the oils main component is guaiacol (Guaiacol), kreosol (Crosol) and other phenols, act on similar to phenol, but its toxicity and zest are all less, be colourless or pale yellow oily liquid, scurrying property cigarette is smelly, flavor burns strong, has pharmacological actions such as anticorrosion, sterilization, local anaesthesia, the clinical treatment that is used for antidiarrheal, whole intestinal and toothache.The Chinese medicine composition of preparation of the present invention has intensive penetrance smoke, for covering the bad smell of medicine, make the patient be easy to accept, the inventor has carried out a large amount of research to the dosage form of preparation and the selection of used adjuvant, moulding process to preparation has carried out performing creative labour simultaneously, finally determines to select for use liquid capsule preparation.
The dry concentrate of the leaf of Maguireothamnus speciosus gambier gambirplant leaf and branchlet (Uncariagambir) and sprout decocting liquid is used as medicine, property hardship, puckery, be slightly cold, nontoxic, go into lung meridian.Its main component is catechin (Cateehin) and Quercetin (Quereetin) etc.Have that removing dampness purges heat, promoting tissue regeneration and ulcer healing, the analgesic therapy hemostasis is promoted the production of body fluid and is reduced phlegm, effects such as astringing to arrest diarrhea.The clinical treatment that is used for diseases such as aphtha, incised wound, skin ulceration, hemorrhoid are swollen, watery diarrhea, endo-enteritis.The Uncaria gambier Roxb. dry extract plays convergence in preparation of the present invention, adjust the effect of enteral moisture.
Cortex Phellodendri (Cortex phellodendri) is the dry bark of Rutaceae Cortex Phellodendri (Phelloden-dron amurense Rupr.), and bitter in the mouth is cold in nature, returns kidney, urinary bladder channel.The main component of Cortex Phellodendri is the bitter rope (Li-monin) of berberine (Berberine) and Fructus Citri Limoniae, and contain a small amount of fibrauretin (Palmatine) and obacunone (Obakunone), staphylococcus aureus, bloody dysentery bacterium, gonococcus etc. there are potent antibacterial action, suppress the cellular antibody generation.Have effects such as antiinflammatory, blood pressure lowering.Clinical warm dysentery, yellow cellulitis, leukorrhagia, pyretic stranguria, beriberi, flaccidity base, the hectic fever due to YIN-deficiency consumptive fever of being used for; Night sweat, seminal emission, sore swollen toxin, the treatment of diseases such as eczema pruritus.Cortex Phellodendri plays antibiotic, spasmolytic effect in preparation of the present invention.
Pericarpium Citri Reticulatae has the be good for the stomach effect of sharp intestinal of fragrance, the inventor studies the plant amedica composition in the preparation of the present invention and the interaction of guaiacol, it is unexpected that the discovery Pericarpium Citri Reticulatae have significant effects to the pharmacokinetic parameter of guaiacol, and the mean dissolution time of guaiacol measured, experimental details is as follows:
Materials and methods: the 1. preparation of pill: with the powder mixes of Uncaria gambier Roxb. dry extract 4g, Cortex Phellodendri 6g, Radix Glycyrrhizae 3g, Pericarpium Citri Reticulatae 6g, add glycerol, water and creosote, in the porcelain alms bowl, knead 5min, make creosote ball (P4R) that is about 4.8mg and the pill (P4R-CUP2) that does not contain Pericarpium Citri Reticulatae, contain the pill (P4R-1/2CUP2) of half amount Pericarpium Citri Reticulatae.2. the mensuration of guaiacol stripping from pill: in (37 ± 0.5) ℃, 6 pills are put into dissolution medium, stir with 100r/min.Respectively at 5,10,20,40, behind the 60min, behind the sampling 1mL, supply volume with fresh medium again.Sample liquid is crossed microporous filter membrane, gets 500 μ L subsequent filtrates, adds mark liquid and 500 μ L ethyl acetate in the 20 μ L.Mixed liquor is stirred 3min, with the centrifugal 3min of 5000r/min, get ethyl acetate layer injection GC-MS system and analyze behind the mixing, observe the stripping of guaiacol from pill.3. pharmacokinetic: the Wistar ST in 10 ages in week is a rat feeding after 2 months, and the rat of choosing body weight 400～450g carries out pharmacokinetic.Fasting 18h is with pentobarbital sodium (30mg/kg) intraperitoneal injection of anesthesia, then in left side jugular vein intubate.P4R is bonded at the stomach probe tip, inserts administration in the stomach, distilled water 0.3mL reinjects.After the administration 0.5,10,20,30,60,90,120,180,240,300min, blood sampling 0.5mL is centrifugal from intubate, one 20 ℃ of preservations of blood plasma.Oral castor oil causes the diarrheal rat model and also tests as stated above.4. the guaiacol concentration in the blood plasma: add buffer in the 150 μ L blood plasma, 37 ℃ of incubation 2h add 1N hydrochloric acid (60 μ L), fluorophenol (20 μ L) and ethyl acetate (1mL) again, stir 3min, with the centrifugal 3min of 5000r/min.The ethyl acetate soluble fraction is analyzed with GC-MS, and the standard curve that gets guaiacol concentration in the blood plasma is Y=0.0005X+0.0086 (r=0.999).
The result: 1. 5,10, during 20min, the dissolution rate of guaiacol from P4R-CUP2 is significantly higher than the dissolution rate of guaiacol from P4R, P4R-1/2CUP2.The MRT of P4R group guaiacol obviously prolongs than P4R-CUP2.Because AUC in two groups the blood
0～5hThere is not significant difference, so think that the effect of Pericarpium Citri Reticulatae prolongation MRT is the influence that is subjected to MDT.2. the diarrhoea of bringing out for Oleum Ricini, Pericarpium Citri Reticulatae also have the effect that prolongs MRT.After diarrhoea group rat was taken medicine, guaiacol concentration was similar to normal rat in the blood plasma, but the T of guaiacol
Max, AUC
0～5h, mean residence time (MRT) is lower than normal group, but C
MaxBe higher than normal group.3. normal rat is taken behind the P4R 5min that contains (286 ± 8) μ g guaiacol and can be detected guaiacol in the blood plasma, and behind 45～115min, guaiacol concentration peaking is lower than detectable limit in the blood plasma behind the 5h.Because prolonging MRT and MDT is the index that medicine has continuous action, therefore think that the lasting anti-diarrhea effect of pill is relevant with Pericarpium Citri Reticulatae.
Radix Glycyrrhizae in the preparation of the present invention has analgesia, detoxifcation, protection gastric mucosa, the effect of coordinating the actions of various ingredients in a prescription.
The inventor selects through a large amount of testing sieves has increased the Cortex cinnamomi japonici (Ramulus Cinnamomi) composition on the basis of original prescription, and determined its consumption, because the Cortex cinnamomi japonici powder Cortex cinnamomi japonici (Ramulus Cinnamomi) has the effect of warming the interior cold expelling, have synergism with other composition, make curative effect improve greatly, disease makes lasting medicine.
The technological difficulties of liquid capsule mainly are the preparation of capsule liquid, and for guaranteeing the uniform and stable of capsule liquid, general capsule liquid is made up of medicine, dispersant and suspending agent.How to select suitable dispersant and suspending agent, need do creationary research.
One, the selection of dispersant: the selection of medicine dispersant is one of key of development liquid capsule, and it should be able to guarantee the accuracy and the stability of formulation of content, thereby guarantees the safety and effectiveness of medicine.At present common dispersants has consumption vegetable oil and Polyethylene Glycol-400 (PEG-400), and the inventor screens above the two consumption by experiment.
Get three parts of Chinese medicine compositions, add soybean oil, Oleum Arachidis hypogaeae semen and the Polyethylene Glycol-400 of capacity respectively, fully mix after colloid mill ground 30 minutes, put in 2000 rev/mins the centrifuge centrifugal 20 minutes, the precipitation situation of observing two mixed liquors the results are shown in Table 1.
The different dispersant sedimentation of table 1 situation result of the test
| Dispersant | The sedimentation situation |
| Soybean oil Oleum Arachidis hypogaeae semen Polyethylene Glycol-400 | Do not find precipitation, vegetable oil and medicated powder not layering are not found precipitation, and precipitation does not appear in vegetable oil and medicated powder not layering, Polyethylene Glycol-400 and not layering of medicated powder |
As seen from the experiment, two kinds of consumption vegetable oil and Polyethylene Glycol-400 all can be used as the dispersant of this prescription.But discover that Polyethylene Glycol-400 pair softgel shell has induration, need to add propylene glycol and regulated; In addition, dry run must appropriately be grasped drying time than very fast when being dispersant with Polyethylene Glycol-400, and overlong time can make softgel shell break, and the time is too short, since liquid aqueous in the liquid capsule, liquid capsule seepage in storage period then caused; Then there is not above-mentioned shortcoming with vegetable oil as dispersant.So vegetable oil is an optimal choice, have good stable for guaranteeing liquid capsule preparation, this prescription preparation selects for use the consumption vegetable oil as dispersant.Through experiment confirm, used vegetable oil can also be Oleum sesami, Oleum Brassicae campestris and other edible vegetable oil, all can obtain essentially identical effect.
Two, the selection of dispersive agent ratio: the consumption of dispersant directly has influence on the yield rate and the loading amount of liquid capsule.Dispersive agent ratio is low excessively, good stability, but mobile poor, be difficult for pelleting, yield rate is low; Dispersive agent ratio is excessive, and the thixotroping value is low, good fluidity, but loading amount is big and be easy to seepage.Therefore screen the dispersant of different proportion, thereby determine optimal proportion.Get the medicated powder of three parts of equivalent, add not commensurability vegetable oil respectively, fully mix, observe its state, the results are shown in Table 2 after colloid mill ground 30 minutes.
The selection result of the test of table 2 dispersive agent ratio
| Dispersant: medicated powder | The medicinal liquid situation |
| 1∶1 1.5∶1 2∶1 | The medicinal liquid thickness, mobile bad medicinal liquid is even, and mobile better medicinal liquid is rarer, good fluidity |
By result in the table as can be known, when the ratio of dispersant and medicated powder was 1.5: 1, the flowability of medicinal liquid can satisfy the requirement of liquid capsule pressing.In that further the test back is definite, be 1.2: 1～1.6: 1 o'clock in ratio, better effects is all arranged, best with 1.4: 1 o'clock.
Three, the selection of suspending agent: in the process of preparation sample, find, when simple medication powder and vegetable oil suspendible, effect is not desirable especially, so it is very necessary needing to select suitable suspending agent, adding its Chinese medicine of liquid capsule of making behind the suspending agent is to be scattered in the oil with molecularity, oil phase enters blood through lymph in vivo, is not subjected to the influence of first pass effect, thereby produces high bioavailability.The kind of suspending agent is a lot of as Cera Flava, lecithin, aluminum monostearate, ethyl cellulose, and suspending agent can be the mixture of above-mentioned one or more.Because the Cera Flava cost is minimum and be easy to get, so the inventor preferentially selects Cera Flava to test as suspending agent, as suspending agent, carries out the screening of suspending agent consumption with different Cera Flava ratios, the results are shown in Table 3.
The selection result of the test of table 3 suspending agent ratio
| Suspending agent accounts for medicated powder | The medicinal liquid situation |
| 2％ 5％ 10％ | Medicinal liquid is inhomogeneous, and it is even the lamination medicinal liquid to occur, no lamination, and easily moulding capsule medicinal liquid is even, no lamination, when treating the moulding capsule, medicinal liquid solidifies |
As can be seen from the above table, the consumption of suspending agent is 5% o'clock of medicated powder, is fit to for this prescription, and medicinal liquid is even, and is easy to the neutralizing liquid capsule.After further testing, find that the Cera Flava consumption is the effect that all can play stably in 4%～7% scope of medicated powder amount, optimised quantity is 6% again.Back inventor still studies other several suspending agents respectively, finds that the suspending agent consumption is at 4%～7% o'clock that medicated powder is, can play the effect of stablizing suspending.It is best suspending agent that final inventor still selects Cera Flava.
In order to guarantee the steady quality of final products, also can in capsule liquid, also to add a certain amount of antiseptic, as parabens, glyceryl monostearate etc., according to circumstances different, addition is also different, and is general in about 0.3% of amount of liquid medicine, as long as reach fungistatic effect.Can also add an amount of surfactant, as the Tweens span, the suitable situation of addition and deciding generally is no more than 1%, with can make capsule liquid mix homogeneously, stabilize to good.
The liquid capsule of the present invention preparation can be covered the smelly and strong taste that burns of scurrying property cigarette of drug substance contents, the problem that change is made us or made groups of people be difficult to take etc., and make that it is clean and tidy, attractive in appearance, swallow easily; Dosage is accurate relatively, and degree of accuracy is higher, can reach the metering of milligram/grain; The bioavailability of medicament height, comparatively speaking, capsule and tablet, pill are different, do not need to add binding agent and pressure during preparation, belong to dissolving or trickle powder again substantially and be scattered in the content, in case disintegrate just together discharges, imitate rapidly so be, it is good obviously also to absorb soon than pill, tablet; The reason that bioavailability of medicament is high, reach the needed haemoconcentration of identical drug effect, the unit administration amount of liquid capsule reaches the curative effect of tablet with identical purpose etc. with regard to reducing relatively, test shows, liquid capsule of the present invention and tablet be once oral 100mtg respectively, 6 example clothes liquid capsule persons are on average peaked at the 1.5h blood level, are 6g/ml; 6 example clothes tablet persons are on average just peaked at the 2.5h blood level, and are had only 3.5 μ g/ml in addition.Improve medicine stability.As photosensitive medicine, meet damp and hot unsettled medicine, the medicine of easy oxidation etc., because its relative closure encystation, so can be prepared into the liquid capsule that adds opacifier, protection medicine is subjected to the effect of oxygen, light in wet and the air, thereby improves its stability; Contain a large amount of creosotes in the Chinese medicine composition of the present invention, be difficult for making ball, tablet, and the liquid capsule preparation of making has digestive tract good absorbing effect, curative effect height, good stability, dosage advantage accurately, carry light and handy, easy to use.
Pharmacodynamics test research
Having of the medicine of the present invention antidiarrheal function that stagnates is used for the treatment of adult that unhygienic diet or being not acclimatized cause and children's's inappetence, nausea and vomiting, abdominal distention, diarrhoea, dyspepsia etc.
This research is adopted Oleum Ricini induced mice diarrhoea and Folium Sennae induced mice diarrheal anti-diarrhea effect, small intestine movement of mice is advanced and to the influence of the hyperfunction model mice intestinal propulsion motion of intestinal due to the neostigmine, to the influence of mice gastric emptying motion and to the test method that influences of rat gastric acid, pepsinia, to verify the drug effect of medicine of the present invention.
1 experiment material
Animal: white mice, the Kunming kind, one-level is qualified, male and female half and half, body weight 18-21g; The SD rat, male and female half and half, body weight 180～200g, more than provide by The Fourth Military Medical University's Experimental Animal Center.
Medicine and reagent: the used preparation of test group is the liquid capsule preparation (creosote 35kg, Uncaria gambier Roxb. 30kg, Cortex Phellodendri 60kg, Radix Glycyrrhizae 8kg, Pericarpium Citri Reticulatae 31kg, Cortex cinnamomi japonici (Ramulus Cinnamomi) 30kg) according to the embodiment of the invention eight preparations, it is the lab scale medicine, lot number 060319 is provided by Jiangxi Yaodu Renhe Pharmaceutical Co., Ltd.Control drug: belly pain is good for the stomach and puts in order intestinal ball, lot number 20051102, pharmaceutical factory, Thailand Lee Wanshan Mountain; Oleum Ricini, commercial, lot number 20060202, Nanchang white clouds medication chemistry factory; Folium Sennae, commercial, face the time spent to be mixed with 15% suspension; The methyl-sulfuric acid neostigmine, lot number: 2006201, letter friendship Pharmaceutical is produced; Metoclopramide, lot number: 20060301, Beijing doube bridge drugmaker; Motilium, lot number: 200601140, Xian-Janssen Pharmaceutical Ltd. produces; Phenol reagent: (Folin-Ciocalteu) compound method is seen " herbal pharmacology experimental methodology ", Li Yikui, Science and Technology of Shanghai publishing house, P242; Bovine hemoglobin, Shanghai uncle bio tech ltd difficult to understand, lot number: G200601; L-Tyrosine, Shanghai uncle bio tech ltd difficult to understand, lot number: 20018402; 0.1% thimerosal, 5% trichloroacetic acid, 0.5mol/l sodium carbonate, 0.3mol/l hydrochloric acid, 0.04mol/l hydrochloric acid.
Instrument: the multi-functional analyzer of BECKMAN series type; PHS-3C type acidometer, Shanghai thunder magnetic instrument plant; Sartrius electronic balance (precision 1/1000).
2 experimental techniques and result
2.1 to Oleum Ricini induced mice diarrheal anti-diarrhea effect
Choose 50 of white mice, be divided into 5 groups at random by body weight, positive drug matched group filling stomach is good for the stomach to belly pain and puts in order the obtain solution 0.4mL/20g of intestinal ball institute, be 1mg/kg, the high, medium and low dosage group of liquid capsule is irritated the dosing 0.4mL/20g of lab scale medicine institute that stomach is given variable concentrations, i.e. 1.8g/kg, 0.9g/kg, 0.45g/kg respectively; Blank group group is irritated the normal saline 0.4mL/20g of stomach equal volume.Successive administration 3 days is irritated stomach and is given Semen Ricini fluid 0.4mL/20g behind the last administration 1h; Then with the mice sub-cage rearing, 1 in every cage, cage heelpiece adularescent filter paper is surveyed the incubation period of its appearance, and every h changes paper 1 time, observes 6h continuously, the loose stool number on the recorder chart.Experimental result sees Table 4.
Table 4 pair Oleum Ricini induced mice diarrheal anti-diarrhea effect
Annotate: compare with the blank group
*P＜0.01,
*P＜0.05 (down together).
Table 4 is the result show, the low and high dose group of liquid capsule can make the loose stool of mice obviously reduce, parallel with positive control (P＜0.01).
2.2 to Folium Sennae induced mice diarrheal anti-diarrhea effect
Choose 50 of white mice, be divided into 5 groups at random by body weight, positive drug matched group filling stomach is good for the stomach to belly pain and puts in order the obtain solution 0.4mL/20g of intestinal ball institute, be 1mg/kg, the high, medium and low dosage group of liquid capsule is irritated the dosing 0.4mL/20g of lab scale medicine institute that stomach is given variable concentrations, i.e. 1.8g/kg, 0.9g/kg, 0.45g/kg respectively; Blank group group is irritated the normal saline 0.4mL/20g of stomach equal volume.Successive administration 3 days is irritated stomach and is given Folium Sennae suspension 0.4mL/20g behind the last administration 1h; With the mice sub-cage rearing, 1 in every cage, cage heelpiece adularescent filter paper are surveyed it, are surveyed the incubation period of its appearance, per hour change paper 1 time, observe 6h continuously, the loose stool number on the recorder chart then.Experimental result sees Table 5.
Table 5 pair Folium Sennae induced mice diarrheal anti-diarrhea effect
Table 5 result as seen, after blank group was given Folium Sennae, the loose stool of mice increased, and has showed symptom of diarrhea, the low dose group of liquid capsule can make the loose stool of mice reduce, and middle and high dosage group can make the loose stool of mice obviously reduce (P＜0.01).
2.3 influence to normal mouse intestinal ahead running
Choose 50 of white mice, be divided into 5 groups at random by body weight, positive drug matched group filling stomach is good for the stomach to belly pain and puts in order the obtain solution 0.4mL/20g of intestinal ball institute, be 1mg/kg, the high, medium and low dosage group of liquid capsule is irritated the dosing 0.4mL/20g of lab scale medicine institute that stomach is given variable concentrations, i.e. 1.8g/kg, 0.9g/kg, 0.45g/kg respectively; Blank group group is irritated the normal saline 0.4mL/20g of stomach equal volume.Successive administration 3 days is irritated stomach and is given active carbon 0.4mL/ only behind the last administration 1h; Putting to death animal after 20 minutes, is starting point with the pylorus, measures the distance that active carbon is pushed into and the total length of small intestinal.Calculate the propelling rate of active carbon then:
Result such as table 6.
The influence of table 6 pair normal mouse intestinal ahead running
Table 6 is the result show, the dosage group can suppress the propelling moving (P≤0.05) of the small intestinal of normal mouse in the liquid capsule, and the visible trend that suppresses intestinal motility of other each group, but not statistically significant.
2.4 neostigmine is caused the influence of the hyperfunction model intestinal propulsion motion of mice intestinal
Choose 50 of white mice, be divided into 5 groups at random by body weight, positive drug matched group filling stomach is good for the stomach to belly pain and puts in order the obtain solution 0.4mL/20g of intestinal ball institute, be 1mg/kg, the high, medium and low dosage group of liquid capsule is irritated the dosing 0.4mL/20g of lab scale medicine institute that stomach is given variable concentrations, i.e. 1.8g/kg, 0.9g/kg, 0.45g/kg respectively; Blank group group is irritated the normal saline 0.4mL/20g of stomach equal volume.Successive administration 5d, last administration 40min lumbar injection neostigmine 0.1mg/kg causes the hyperfunction model of small intestinal, irritating stomach behind the 15min gives active carbon 0.4mL/ only, putting to death animal behind the 20min, is starting point with the pylorus, measures the distance that active carbon is pushed into and the total length of small intestinal.Calculate the propelling rate of active carbon then:
Result such as table 7.
Table 7 pair neostigmine causes the inhibitory action of the hyperfunction model intestinal propulsion motion of mice intestinal
Table 7 is the result show, the ahead running (P＜0.01) of the small intestinal of the hyperfunction model that low and high dose group can obviously suppress.Middle dosage group has the trend that suppresses motion, but not statistically significant.
2.5 influence to the motion of normal mouse gastric emptying
Choose 50 of white mice, be divided into 5 groups at random by body weight, positive drug matched group filling stomach is good for the stomach to belly pain and puts in order the obtain solution 0.4mL/20g of intestinal ball institute, be 1mg/kg, the high, medium and low dosage group of liquid capsule is irritated the dosing 0.4mL/20g of lab scale medicine institute that stomach is given variable concentrations, i.e. 1.8g/kg, 0.9g/kg, 0.45g/kg respectively; Blank group group is irritated the normal saline 0.4mL/20g of stomach equal volume.Successive administration 5d, last administration 1h irritate stomach and give gelatinized corn starch 0.8mL/ only, put to death animal behind the 20min, and ligation cardia and pylorus are got stomach then.The full weight of stomach with clean after the net weight difference for being residual quantity, and then calculate residual rate.Experimental result sees Table 8.
The facilitation of table 8 pair normal mouse gastric emptying motion
Table 8 as seen, the middle dosage of liquid capsule can promote the gastric emptying motion of mice, with matched group relatively (P＜0.05).
2.6 to the pepsic influence of rat gastric acid
Choose 50 of white mice, be divided into 5 groups at random by body weight, positive drug matched group filling stomach is good for the stomach to belly pain and puts in order the obtain solution 0.4mL/20g of intestinal ball institute, be 1mg/kg, the high, medium and low dosage group of liquid capsule is irritated the dosing 0.4mL/20g of lab scale medicine institute that stomach is given variable concentrations, i.e. 1.8g/kg, 0.9g/kg, 0.45g/kg respectively; Blank group group is irritated the normal saline 0.4mL/20g of stomach equal volume.
Successive administration 10d, fasting 48 hours is freely drunk water.The etherization animal is used in the back, cuts off the hair of abdominal part, and routine disinfection skin is opened the otch of about 2.5cm in xiphoid-process lower edge hunter's line, and the careful stomach of mentioning in pylorus and the suture ligation of duodenum joint portion, is avoided blood vessel.The syringe duodenal administration is used in the back, sends back to after the stitching in the cage, and water is prohibited in the postoperative fasting, and 5 hours femoral vein are got blood and put to death animal, take out stomach, collect gastric juice in graduated centrifuge tube, with the centrifugal 15min of 3000r/min, draws supernatant and surveys gastric acid, pepsin respectively.The gastric acid amount is calculated by the NaoH of the 0.01mmol/L that consumes; Pepsin is pressed " herbal pharmacology experimental methodology ", Li Yikui, Science and Technology of Shanghai publishing house, and P242 stipulates pepsic assay method.Experimental result sees Table 9.
The influence of table 9 pair rat gastric acid pepsin activity
Table 9 is the result show, the middle and high dosage group of liquid capsule can improve pepsic activity, has statistical significance, compares (P＜0.01) with matched group.
3 discuss
Experimentation by pharmacodynamics shows that medicine of the present invention can significantly reduce the loose stool number of mice, has anti-diarrhea effect; Can promote the gastric emptying motion of mice; The intestinal propulsion of the hyperfunction model mice of intestinal motion due to inhibition normal mouse and the neostigmine, thereby the absorption of promotion nutrient substance; Promote the secretion of gastric juice and suppress pepsic activity, improve digestive function.Thereby for treatment inappetence, nausea and vomiting, abdominal distention, diarrhoea, dyspepsia etc. provide the pharmacodynamics foundation.
The specific embodiment:
Embodiment one
Capsule liquid: Chinese medicine composition 10kg, soybean oil 12kg, Cera Flava 0.4kg
Forming of described Chinese medicine composition by creosote 50kg, Uncaria gambier Roxb. 120kg, Cortex Phellodendri 10kg, Radix Glycyrrhizae 35kg, Pericarpium Citri Reticulatae 30kg, Cortex cinnamomi japonici (Ramulus Cinnamomi) 45kg processing and preparing;
Preparation method:
The preparation of creosote:
Place distillating still to distill Fagaceae plant Fagus sinensis Oliv., get dry distillation liquid and under 180 ℃ of conditions, distill, collect the fraction heavier, handle as follows than water:
1. add percentage by weight and be 15% sodium hydroxide solution, stir crystallisation by cooling;
2. filter, discard filtrate, the washing of filtering residue clear water discards washings, adding weight percent concentration is 35% sulfuric acid solution, stirs, and discards sulfate wastewater, clear water washing back is rectification under vacuum under the 0.08-0.09MPa condition in vacuum, collects 130-155 ℃ rectification branch, promptly gets wooden pomegranate oil;
Described fraction: sodium hydroxide solution: the weight part ratio of sulfuric acid solution is 1: 2: 3;
The preparation of preparation:
Uncaria gambier Roxb., Cortex Phellodendri, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Cortex cinnamomi japonici (Ramulus Cinnamomi) are decocted with water 2 times, and 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, and the survey relative density was 1.15 thick paste when filtrate was condensed into 60 ℃; Wherein amount of water is respectively Uncaria gambier Roxb., Cortex Phellodendri, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Cortex cinnamomi japonici (Ramulus Cinnamomi) gross weight 10,8 times; The 50kg creosote is joined in the thick paste, stir, get Chinese medicine composition.
Get Chinese medicine composition 10kg and add dispersant soybean oil and suspending agent Cera Flava, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell
Embodiment two
Capsule liquid: Chinese medicine composition 12kg, Oleum Arachidis hypogaeae semen 16kg, lecithin 0.7kg, tween 80 0.1kg
Described Chinese medicine composition is to be prepared from by creosote 20kg, Uncaria gambier Roxb. 150kg, Cortex Phellodendri 35kg, Radix Glycyrrhizae 14kg, Pericarpium Citri Reticulatae 20kg, Cortex cinnamomi japonici (Ramulus Cinnamomi) 60kg;
Preparation method:
The preparation of creosote:
Place distillating still to distill natural Zelkova schneideriana Hand.-Mazz., get dry distillation liquid and under 200 ℃ of conditions, distill, collect the fraction heavier, handle as follows than water:
1. add percentage by weight and be 5% sodium hydroxide solution, stir, add percentage by weight and be 15% calcium acetate solution, crystallisation by cooling;
2. filter, discard filtrate, the washing of filtering residue clear water discards washings, adding weight percent concentration is 25% sulfuric acid solution, stirs, and discards sulfate wastewater, clear water washing back is rectification under vacuum under the 0.08-0.09MPa condition in vacuum, collects 130-155 ℃ rectification branch, promptly gets wooden pomegranate oil;
Described fraction: sodium hydroxide solution: calcium acetate solution: the weight part ratio of sulfuric acid solution is 2: 3: 5: 2.5;
The preparation of preparation:
Uncaria gambier Roxb., Cortex Phellodendri, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Cortex cinnamomi japonici (Ramulus Cinnamomi) are decocted with water 3 times, and 2 hours for the first time, 3 hours for the second time, 1 hour for the third time, collecting decoction filtered, and the survey relative density was 1.20 thick paste when filtrate was condensed into 60 ℃; Wherein amount of water is respectively Uncaria gambier Roxb., Cortex Phellodendri, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Cortex cinnamomi japonici (Ramulus Cinnamomi) gross weight 8,10,6 times; The 20kg creosote is joined in the thick paste, stir, get Chinese medicine composition;
Get Chinese medicine composition 12kg and add dispersant Oleum Arachidis hypogaeae semen, suspending agent lecithin and surfactant tween 80, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Embodiment three
Capsule liquid: Chinese medicine composition 14kg, Polyethylene Glycol-20013kg, aluminum monostearate 0.2kg, propylene glycol 0.4kg, ethyl hydroxybenzoate 0.1kg, tween 20 0.1kg;
Described Chinese medicine composition is to be prepared from by creosote 40kg, Uncaria gambier Roxb. 110kg, Cortex Phellodendri 30kg, Radix Glycyrrhizae 10kg, Pericarpium Citri Reticulatae 40kg, Cortex cinnamomi japonici (Ramulus Cinnamomi) 40kg;
Preparation method:
The preparation of creosote:
Place distillating still to distill maple, get dry distillation liquid and under 360 ℃ of conditions, distill, collect the fraction heavier, handle as follows than water:
1. add percentage by weight and be 20% sodium hydroxide solution, stir, add percentage by weight and be 30% magnesium acetate solution, crystallisation by cooling;
2. filter, discard filtrate, the washing of filtering residue clear water discards washings, adding weight percent concentration is 20% sulfuric acid solution, stirs, and discards sulfate wastewater, clear water washing back is rectification under vacuum under the 0.08-0.09MPa condition in vacuum, collects 130-155 ℃ rectification branch, promptly gets wooden pomegranate oil;
Described fraction: sodium hydroxide solution: magnesium acetate solution: the weight part ratio of sulfuric acid solution is 3: 4: 7: 3.5;
The preparation of preparation:
Uncaria gambier Roxb., Cortex Phellodendri, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Cortex cinnamomi japonici (Ramulus Cinnamomi) are decocted with water 2 times, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and the survey relative density was 1.30 thick paste when filtrate was condensed into 60 ℃; Wherein amount of water be respectively Uncaria gambier Roxb., Cortex Phellodendri, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Cortex cinnamomi japonici (Ramulus Cinnamomi) gross weight 6,8, doubly; The 40kg creosote is joined in the thick paste, stir, get Chinese medicine composition;
Get Chinese medicine composition 14kg and add dispersant Polyethylene Glycol-200, suspending agent aluminum monostearate and ethyl cellulose, antiseptic ethyl hydroxybenzoate, surfactant tween 20, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell
Embodiment four
Capsule liquid: Chinese medicine composition 6kg, Oleum Brassicae campestris 15kg, aluminum monostearate 0.5kg, glycerol monostearate 0.1kg, Tween-60 0.1kg;
Described Chinese medicine composition is to be prepared from by creosote 41kg, Uncaria gambier Roxb. 75kg, Cortex Phellodendri 25kg, Radix Glycyrrhizae 25kg, Pericarpium Citri Reticulatae 15kg, Cortex cinnamomi japonici (Ramulus Cinnamomi) 55kg;
Preparation method:
The preparation of creosote:
Place distillating still to distill Xylosmae japonici, get dry distillation liquid and under 300 ℃ of conditions, distill, collect the fraction heavier, handle as follows than water:
1. add percentage by weight and be 10% potassium hydroxide solution, stir, add percentage by weight and be 10% magnesium acetate solution, crystallisation by cooling;
2. filter, discard filtrate, the washing of filtering residue clear water discards washings, adding weight percent concentration is 30% sulfuric acid solution, stirs, and discards sulfate wastewater, clear water washing back is rectification under vacuum under the 0.08-0.09MPa condition in vacuum, collects 130-155 ℃ rectification branch, promptly gets wooden pomegranate oil;
Described fraction: potassium hydroxide solution: magnesium acetate solution: the weight part ratio of sulfuric acid solution is 2.5: 3: 4: 2;
The preparation of preparation:
Wherein the preparation method of Chinese medicine composition is with embodiment three, and the survey relative density is 1.10 thick paste when wherein filtrate being condensed into 60 ℃;
Get Chinese medicine composition 6kg and add dispersant Oleum Brassicae campestris, suspending agent aluminum monostearate, antiseptic glycerol monostearate, surfactant Tween-60, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Embodiment five
Capsule liquid: Chinese medicine composition 8kg, Polyethylene Glycol-40013kg, Cera Flava 0.3kg, lecithin 0.2kg, ethyl hydroxybenzoate 0.1kg, tween 20 0.1kg;
Described Chinese medicine composition is to be prepared from by pine tar 60kg, Uncaria gambier Roxb. 200kg, Cortex Phellodendri 50kg, Radix Glycyrrhizae 16kg, Pericarpium Citri Reticulatae 29kg, Cortex cinnamomi japonici (Ramulus Cinnamomi) 70kg;
Preparation method:
The preparation of pine tar:
Place distillating still to distill pinaster, get dry distillation liquid and under 280 ℃ of conditions, distill, collect the fraction heavier, handle as follows than water:
1. add percentage by weight and be 12% potassium hydroxide solution, stir, add percentage by weight and be 20% magnesium acetate solution, crystallisation by cooling;
2. filter, discard filtrate, the washing of filtering residue clear water discards washings, adding weight percent concentration is 28% sulfuric acid solution, stirs, and discards sulfate wastewater, clear water washing back is rectification under vacuum under the 0.08-0.09MPa condition in vacuum, collects 130-155 ℃ rectification branch, promptly gets unguentum picis pini;
Described fraction: potassium hydroxide solution: magnesium acetate solution: the weight part ratio of sulfuric acid solution is 1.5: 2.5: 6: 3;
The preparation of preparation:
1. getting Cortex Phellodendri is 90% alcohol heating reflux 2 times in percent by volume, 2 hours for the first time, and 1.5 hours for the second time, filter, merging filtrate, filtrate recycling ethanol extremely do not have the alcohol flavor, filter, and get filtrate A;
2. Uncaria gambier Roxb., Radix Glycyrrhizae, Pericarpium Citri Reticulatae and Cortex cinnamomi japonici (Ramulus Cinnamomi) are decocted with water 3 times, 2 hours for the first time, 3 hours for the second time, 1 hour for the third time, collecting decoction filtered, and the survey relative density was 1.10 extractum B when filtrate was concentrated into 60 ℃; Wherein amount of water is respectively Uncaria gambier Roxb., Radix Glycyrrhizae, Pericarpium Citri Reticulatae and Cortex cinnamomi japonici (Ramulus Cinnamomi) gross weight 10,8,6 times;
3. filtrate A is mixed with extractum B, relative density is 1.30 extractum when being concentrated into 60 ℃, and drying is made fine powder, adds the 60kg pine tar, stirs, and gets Chinese medicine composition;
Get Chinese medicine composition 8kg and add dispersant Polyethylene Glycol-400, suspending agent Cera Flava and lecithin, antiseptic ethyl hydroxybenzoate, surfactant tween 20, colloid mill is ground to mix homogeneously, adopts filling in No. 1 capsule softgel shell, is prepared into liquid capsule.
Embodiment six
Capsule liquid: Chinese medicine composition 15kg, Oleum sesami 14kg, ethyl cellulose 0.6kg, glycerol monostearate 0.1kg, Arlacel-60 0.1kg;
Described Chinese medicine composition is to be prepared from by bamboo tar 30kg, Uncaria gambier Roxb. 140kg, Cortex Phellodendri 40kg, Radix Glycyrrhizae 30kg, Pericarpium Citri Reticulatae 25kg, Cortex cinnamomi japonici (Ramulus Cinnamomi) 35kg;
Preparation method:
The preparation of bamboo tar:
Place distillating still to distill in bamboo, getting dry distillation liquid distills under 180 ℃ of conditions, the collection fraction heavier than water places rectifying still, in temperature is 130-155 ℃, withdrawing moisture and light fraction under the vacuum 0.08-0.09MPa condition, with the crystallization in freezing 12 hours under subzero 20 conditions of the fraction in the rectifying still, the crystal centrifugalize obtains the bamboo tar crystal, place normal temperature condition, standby;
The preparation of preparation:
1. getting Cortex Phellodendri is 75% alcohol heating reflux 3 times in percent by volume, 3 hours for the first time, and 2 hours for the second time, 1 hour for the third time, filter, merging filtrate, filtrate recycling ethanol extremely do not have the alcohol flavor, filter, and get filtrate A;
2. Uncaria gambier Roxb., Radix Glycyrrhizae, Pericarpium Citri Reticulatae and Cortex cinnamomi japonici (Ramulus Cinnamomi) are decocted with water 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and the survey relative density was 1.20 extractum B when filtrate was concentrated into 60 ℃; Wherein amount of water is Uncaria gambier Roxb., Radix Glycyrrhizae, Pericarpium Citri Reticulatae and Cortex cinnamomi japonici (Ramulus Cinnamomi) gross weight 8,6 times;
3. filtrate A is mixed with extractum B, relative density is 1.10 extractum when being concentrated into 60 ℃, and drying is made fine powder, adds the 30kg bamboo tar, stirs, and gets Chinese medicine composition;
Get Chinese medicine composition 15kg and add dispersant Oleum sesami, suspending agent ethyl cellulose, antiseptic glycerol monostearate, surfactant Arlacel-60, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell
Embodiment seven
Capsule liquid: Chinese medicine composition 9kg, Oleum Brassicae campestris 14.5kg, aluminum monostearate 0.5kg, ethyl cellulose 0.1kg, glycerol monostearate 0.1kg, Tween-40 0.15kg;
Described Chinese medicine composition is prepared from by creosote 55kg, Uncaria gambier Roxb. 50kg, Cortex Phellodendri 65kg, Radix Glycyrrhizae 20kg, Pericarpium Citri Reticulatae 35kg, Cortex cinnamomi japonici (Ramulus Cinnamomi) 60kg;
Preparation method:
The preparation of creosote:
Place distillating still to distill Quercus acutissima Carr., getting dry distillation liquid distills under 360 ℃ of conditions, the collection fraction heavier than water places rectifying still, in temperature is 130-155 ℃, withdrawing moisture and light fraction under the vacuum 0.08-0.09MPa condition, with the crystallization in freezing 48 hours under 0 ℃ of condition of the fraction in the rectifying still, the crystal centrifugalize obtains the creosote crystal, place normal temperature condition, standby;
The preparation of preparation:
1. getting Cortex Phellodendri is 60% alcohol heating reflux 2 times in percent by volume, 1.5 hours for the first time, and 3 hours for the second time, filter, merging filtrate, filtrate recycling ethanol extremely do not have the alcohol flavor, filter, and get filtrate A;
2. Uncaria gambier Roxb., Radix Glycyrrhizae, Pericarpium Citri Reticulatae and Cortex cinnamomi japonici (Ramulus Cinnamomi) are decocted with water 2 times, 3 hours for the first time, 1 hour for the second time, collecting decoction filtered, and the survey relative density was 1.30 extractum B when filtrate was concentrated into 60 ℃; Wherein amount of water is Uncaria gambier Roxb., Radix Glycyrrhizae, Pericarpium Citri Reticulatae and Cortex cinnamomi japonici (Ramulus Cinnamomi) gross weight 9,8,6 times;
3. filtrate A is mixed with extractum B, relative density is 1.20 extractum when being concentrated into 60 ℃, and drying is made fine powder, adds the 55kg creosote, stirs, and gets Chinese medicine composition;
Get Chinese medicine composition 9kg and add dispersant Oleum Brassicae campestris, suspending agent aluminum monostearate and ethyl cellulose, antiseptic glycerol monostearate, surfactant Arlacel-40, colloid mill is ground to mix homogeneously, adopts filling in No. 1 capsule softgel shell, is prepared into liquid capsule.
Embodiment eight
Capsule liquid: Chinese medicine composition 12.5kg, Polyethylene Glycol-60013kg, propylene glycol 0.55kg, ethyl hydroxybenzoate 0.1kg, Tween-40 0.12kg
Described Chinese medicine composition is to be prepared from by creosote 35kg, Uncaria gambier Roxb. 30kg, Cortex Phellodendri 60kg, Radix Glycyrrhizae 8kg, Pericarpium Citri Reticulatae 31kg, Cortex cinnamomi japonici (Ramulus Cinnamomi) 30kg;
Preparation method:
The preparation of creosote:
Place distillating still to distill natural Zelkova schneideriana Hand.-Mazz., getting dry distillation liquid distills under 220 ℃ of conditions, the collection fraction heavier than water places rectifying still, in temperature is 130-155 ℃, withdrawing moisture and light fraction under the vacuum 0.08-0.09MPa condition, with the crystallization in freezing 20 hours under subzero 10 ℃ of conditions of the fraction in the rectifying still, the crystal centrifugalize obtains the creosote crystal, place normal temperature condition, standby;
The preparation of preparation:
The preparation method of Chinese medicine composition is with embodiment five;
Wherein 1. step is processed into coarse powder with Cortex Phellodendri, is solvent with 10 times of amount saturated limewaters, supersound extraction 2 times, 20min for the first time, 10min is mixed with extracting solution the solution of counting 33.33mg/ml with crude drug for the second time, filter, add the NaCl placement and spend the night, filter oven dry, in precipitation, be dissolved in water, filter, it is 1～2 that filtrate adds hydrochloric acid accent pH, treats that post precipitation filters, and gets filtrate A;
Get Chinese medicine composition 12.5kg and add dispersant Polyethylene Glycol-600, suspending agent propylene glycol, antiseptic list ethyl hydroxybenzoate, surfactant Tween-40, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Embodiment nine
Capsule liquid: Chinese medicine composition 7.5kg, soybean oil 15.5kg, Cera Flava 0.45kg, single ethyl hydroxybenzoate 0.1kg, Tween-40 0.12kg
Described Chinese medicine composition is to be prepared from by creosote 45kg, Uncaria gambier Roxb. 90kg, Cortex Phellodendri 29kg, Radix Glycyrrhizae 15kg, Pericarpium Citri Reticulatae 50kg, Cortex cinnamomi japonici (Ramulus Cinnamomi) 65kg;
Preparation method:
The preparation method of wood pomegranate oil is with embodiment three;
The preparation method of Chinese medicine composition is with embodiment six;
Step is solvent 1. for Cortex Phellodendri is processed into coarse powder with 8 times of amount saturated limewaters, supersound extraction 3 times, 30 minutes for the first time, 20 minutes for the second time, 15 minutes for the third time, extracting solution is mixed with the solution of counting 35mg/ml with crude drug, filters, add the NaCl placement and spend the night, filter, oven dry is dissolved in water in precipitation, filters, and it is 1～2 that filtrate adds hydrochloric acid accent pH, treat that post precipitation filters, and gets filtrate A;
Get Chinese medicine composition 7.5kg and add dispersant soybean oil, suspending agent Cera Flava, antiseptic list ethyl hydroxybenzoate, surfactant Tween-40, colloid mill is ground to mix homogeneously, adopt dropping preparation method to be packed into softgel shell, filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Embodiment ten
Capsule liquid: Chinese medicine composition 10.5kg, Oleum sesami 12.5kg, ethyl cellulose 0.65kg, single ethyl hydroxybenzoate 0.1kg, Tween-40 0.12kg
Described Chinese medicine composition is to be prepared from by creosote 39kg, Uncaria gambier Roxb. 180kg, Cortex Phellodendri 45kg, Radix Glycyrrhizae 12kg, Pericarpium Citri Reticulatae 45kg, Cortex cinnamomi japonici (Ramulus Cinnamomi) 70kg;
Preparation method:
The preparation method of wood pomegranate oil is with embodiment four;
The preparation method of Chinese medicine composition is with embodiment eight;
Wherein step is solvent 1. for Cortex Phellodendri is processed into coarse powder with 12 times of amount saturated limewaters, supersound extraction 3 times, 30 minutes for the first time, 20 minutes for the second time, 15 minutes for the third time, extracting solution is mixed with the solution of counting 30mg/ml with crude drug, filters, add the NaCl placement and spend the night, filter, oven dry is dissolved in water in precipitation, filters, and it is 1～2 that filtrate adds hydrochloric acid accent pH, treat that post precipitation filters, and gets filtrate A;
Get Chinese medicine composition 10.5kg and add dispersant Oleum sesami, suspending agent ethyl cellulose, antiseptic list ethyl hydroxybenzoate, surfactant Tween-40, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Embodiment 11
Capsule liquid: Chinese medicine composition 14.5kg, Oleum Arachidis hypogaeae semen 14.3kg, lecithin 0.48kg, single ethyl hydroxybenzoate 0.1kg, Tween-40 0.12kg
Described Chinese medicine composition is to be prepared from by creosote 25kg, Uncaria gambier Roxb. 130kg, Cortex Phellodendri 20kg, Radix Glycyrrhizae 32kg, Pericarpium Citri Reticulatae 43kg, Cortex cinnamomi japonici (Ramulus Cinnamomi) 50kg;
Preparation method:
Wherein the preparation method of pine tar is with embodiment five;
The preparation method of Chinese medicine composition is with embodiment seven;
Wherein step is a solvent with 10,9 times of amount saturated limewaters respectively 1. for Cortex Phellodendri is processed into coarse powder, supersound extraction 2 times, 25 minutes for the first time, 20 minutes for the second time, extracting solution is mixed with the solution of counting 34mg/ml with crude drug, add the NaCl placement and spend the night, filter, oven dry is dissolved in water in precipitation, filters, and it is 1～2 that filtrate adds hydrochloric acid accent pH, treat that post precipitation filters, and gets filtrate A;
Get Chinese medicine composition 14.5kg and add dispersant Oleum Arachidis hypogaeae semen, suspending agent lecithin, antiseptic list ethyl hydroxybenzoate, surfactant Tween-40, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Claims (15)
1. one kind is used for the treatment of inappetence, nausea and vomiting, abdominal distention diarrhoea, dyspeptic herb liquid body capsule, comprises softgel shell and capsule liquid, it is characterized in that described capsule liquid comprises following components by part by weight:
Chinese medicine composition 6-15 dispersant 12-16 suspending agent 0.4～0.7;
Described Chinese medicine composition is formed by the following components in part by weight processing and preparing:
Heat up in a steamer oily 20-60 Uncaria gambier Roxb. 30-200 Cortex Phellodendri 10-60
Radix Glycyrrhizae 8-35 Pericarpium Citri Reticulatae 15-50 Cortex cinnamomi japonici (Ramulus Cinnamomi) 30-70.
2. according to the described herb liquid body capsule of claim 1, it is characterized in that described Chinese medicine composition is formed through processing and preparing by following parts by weight of Chinese traditional medicine raw material:
Heat up in a steamer oily 30-50 Uncaria gambier Roxb. 50-150 Cortex Phellodendri 15-30
Radix Glycyrrhizae 10-30 Pericarpium Citri Reticulatae 20-40 Cortex cinnamomi japonici (Ramulus Cinnamomi) 40-60.
3. according to the described herb liquid body capsule of claim 2, it is characterized in that described Chinese medicine composition is formed through processing and preparing by following parts by weight of Chinese traditional medicine raw material:
Heat up in a steamer oily 35-45 Uncaria gambier Roxb. 75-120 Cortex Phellodendri 30-40
Radix Glycyrrhizae 15-20 Pericarpium Citri Reticulatae 30-40 Cortex cinnamomi japonici (Ramulus Cinnamomi) 40-60.
4. according to claim 1,2 or 3 described Chinese medicine compositions, it is characterized in that the described oil that heats up in a steamer is creosote, pine tar or bamboo tar.
5. according to claim 1,2 or 3 described herb liquid body capsules, it is characterized in that described dispersant is polyethylene glycols or vegetable oil; Described suspending agent is one or more the mixture in Cera Flava, lecithin, aluminum monostearate, ethyl cellulose, the propylene glycol.
6. herb liquid body capsule as claimed in claim 5 is characterized in that described vegetable oil is a kind of or wherein several mixture of Oleum Arachidis hypogaeae semen, soybean oil, Oleum sesami, Oleum Brassicae campestris or other consumption vegetable oil.
7. as claim 1,2 or 3 described herb liquid body capsules, it is characterized in that containing in the described capsule liquid antiseptic and/or the surfactant of convention amount.
8. herb liquid body capsule as claimed in claim 7 is characterized in that described antiseptic is parabens or glycerol monostearate; Described surface activity reaches and is tween or span.
9. a method for preparing claim 1,2 or 3 described herb liquid body capsules comprises the steps:
Uncaria gambier Roxb., Cortex Phellodendri, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Cortex cinnamomi japonici (Ramulus Cinnamomi) are decocted with water 2-3 time, and each 1-3 hour, collecting decoction filtered, and surveying relative density when filtrate is condensed into 60 ℃ is the thick paste of 1.10-1.30; Wherein amount of water be Uncaria gambier Roxb., Cortex Phellodendri, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Cortex cinnamomi japonici (Ramulus Cinnamomi) gross weight 6-10 doubly; To heat up in a steamer oil and join in the thick paste, and stir, and get Chinese medicine composition, and add dispersant and suspending agent, colloid mill is ground to mix homogeneously, gets capsule liquid, and filling is prepared into liquid capsule in the capsule softgel shell.
10. a method for preparing claim 1,2 or 3 described herb liquid body capsules comprises the steps:
1. getting Cortex Phellodendri is 60～90% alcohol heating reflux 2～3 times in percent by volume, each 1～3 hour, filter, and merging filtrate, filtrate recycling ethanol extremely do not have the alcohol flavor, filter, and get filtrate A; Or,
Cortex Phellodendri is processed into coarse powder, and doubly measuring saturated limewater with 8-12 is solvent, supersound extraction 2-3 time, 15-30min/ time, extracting solution is mixed with the solution of counting 30-35mg/ml with crude drug, filters, add the NaCl placement and spend the night, filter, oven dry is dissolved in water in precipitation, filters, and it is 1～2 that filtrate adds hydrochloric acid accent pH, treat that post precipitation filters, and gets filtrate A;
2. Uncaria gambier Roxb., Radix Glycyrrhizae, Pericarpium Citri Reticulatae and Cortex cinnamomi japonici (Ramulus Cinnamomi) are decocted with water 2～3 times, each 1～3 hour, collecting decoction filtered, and the survey relative density was 1.10～1.30 extractum B when filtrate was concentrated into 60 ℃; Wherein amount of water is Uncaria gambier Roxb., Radix Glycyrrhizae, Pericarpium Citri Reticulatae and Cortex cinnamomi japonici (Ramulus Cinnamomi) gross weight 6～10 times;
3. filtrate A is mixed with extractum B, relative density is 1.10～1.30 extractum when being concentrated into 60 ℃, and drying is made fine powder, add and heat up in a steamer oil, stir, get Chinese medicine composition, add dispersant and suspending agent, colloid mill is ground to mix homogeneously, get capsule liquid, filling is prepared into liquid capsule in the capsule softgel shell.
11. according to claim 9 or 10 described methods, it is characterized in that described Fagaceae plant Fagus sinensis Oliv. Fagus sinensis Oliv., natural beech section natural plant Zelkova schneideriana Hand.-Mazz., maple, Xylosmae japonici, Quercus acutissima Carr., Pinaceae pinaceae Pinus pinus plant pinaster or Juniperus rigida Sieb.et Zucc., bamboo places distillating still to distill, get dry distillation liquid and under 180-360 ℃ of condition, distill, collect the fraction heavier, handle as follows than water:
1. add the aqueous slkali that percentage by weight is 5-20%, stir crystallisation by cooling;
2. filter, discard filtrate, the washing of filtering residue clear water discards washings, adding weight percent concentration is the 20-35% sulfuric acid solution, stirs, and discards sulfate wastewater, clear water washing back is rectification under vacuum under the 0.08-0.09MPa condition in vacuum, collects 130-155 ℃ rectification branch, promptly;
Described fraction: aqueous slkali: the weight part ratio of sulfuric acid solution is 1-3: 2-4: 2-3.5.
12. in accordance with the method for claim 11, it is characterized in that adding again after 1. described step stirs calcium acetate or the magnesium acetate solution that percentage by weight is 10-30%; Described fraction: the weight part ratio of calcium acetate or magnesium acetate is 1-3: 4-7.
13. in accordance with the method for claim 12, it is characterized in that described step aqueous slkali 1. is sodium hydroxide or potassium hydroxide solution.
14. according to claim 9 or 10 described methods, it is characterized in that described Fagaceae plant Fagus sinensis Oliv. Fagus sinensis Oliv., natural beech section natural plant Zelkova schneideriana Hand.-Mazz., maple, Xylosmae japonici, Quercus acutissima Carr., Pinaceae pinaceae Pinus pinus plant pinaster or Juniperus rigida Sieb.et Zucc., bamboo places distillating still to distill, getting dry distillation liquid distills under 180-360 ℃ of condition, the collection fraction heavier than water places rectifying still, in temperature is 130-155 ℃, withdrawing moisture and light fraction under the vacuum 0.08-0.09MPa condition, with the freezing 12-48 hour crystallization under subzero 20 to 0 ℃ of conditions of the fraction in the rectifying still, the crystal centrifugalize obtains heating up in a steamer oily crystal.
15., it is characterized in that also adding antiseptic and/or surfactant in the described capsule liquid according to claim 9 or 10 described methods.
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