CN101152164B - Anti-cicatrix externally used pad pasting containing anti-hypertrophy cell medicament and method for preparing the same - Google Patents
Anti-cicatrix externally used pad pasting containing anti-hypertrophy cell medicament and method for preparing the same Download PDFInfo
- Publication number
- CN101152164B CN101152164B CN2007100926950A CN200710092695A CN101152164B CN 101152164 B CN101152164 B CN 101152164B CN 2007100926950 A CN2007100926950 A CN 2007100926950A CN 200710092695 A CN200710092695 A CN 200710092695A CN 101152164 B CN101152164 B CN 101152164B
- Authority
- CN
- China
- Prior art keywords
- medicine
- silicon gel
- sensitive adhesive
- pad pasting
- cicatrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses an anti-cicatricial topical drug film containing anti-mast cell medicine and the preparation method. The anti-cicatricial topical drug film contains silica gel drug film, which is added with anti-mast cell medicine. The anti-cicatricial topical drug film of the invention is capable of effectively curing scar. After the drug combination in the drug film is screened and the drug combination is optimized, the anti-cicatricial topical drug film does not change the hormone levels of patients. Thereby, the invention is not only fit for curing scars of common population and children, but also capable of curing wounds except severe infection. Besides, the product improves the treating effect of gel scar drug film and widens the scope of treating population. The anti-cicatricial topical drug film of the invention is characterized by simple preparation process and low cost.
Description
Technical field
The present invention relates to external used medicine pad pasting and preparation method thereof, particularly a kind of anti-cicatrix externally used pad pasting that contains anti-mastocyte class medicine and preparation method thereof.
Background technology
The treatment of cicatrix of skin is a surgery difficult problem, and silicon gel cicatrix subsides at present are commonplace effective means that are used for the treatment of cicatrix of skin, but clinical therapeutic efficacy is limited.The therapeutic effect that how further to improve the subsides of silicon gel cicatrix is the problem that presses for solution at present, but does not still have the progress of this respect both at home and abroad, and the patient has intensive demand to such external curing, so very wide to this Products Development prospect.The prevention of patient's cicatrix after adversary's postoperative, wound, the treatment, only with regard to burn patient, by China's authoritative department statistics, annual morbidity is 5-10 ‰, and about 10% needs hospitalization.
In the prior art, it is the simple externally used pad pasting that does not add medicine that silicon gel cicatrix is pasted, and the silicon gel has been made adhering pressure sensitive adhesive, and the outside backing covers the polyethylene adventitia, and the centre adds the elastic force net.Occurring silicon gel cicatrix subsides adding medicine afterwards has the silicon gel medicine cicatrix that adds the hormone triamcinolone acetonide to paste, along with development of material technology, silicon gel cicatrix is pasted the outside backing and can be replaced with the silicone rubber of remodeling, intensity and breathability reach the pharmacopeia requirement fully, to paste physicochemical property identical with the silicon gel cicatrix of clinical usefulness, and reduce cost and reduce processing technology.But the silicon gel medicine cicatrix that adds the hormone triamcinolone acetonide is pasted because the side effects of pharmaceutical drugs of triamcinolone acetonide, can cause allergic reaction, as skin burn feeling, pruritus, prickling sensation etc. appear, and atrophoderma, telangiectasis, pigmentation and secondary infection can occur during life-time service, and cause the change of patient's hormonal readiness easily.Therefore there is limitation in the use, can not uses for the wound surface that infection is arranged, and can not be used for the treatment of child's cicatrix.But the cicatrix of the wound surface of Gan Raning is very common clinically, and child's cicatrix also is a very important treatment colony.
Therefore need a kind of anti-cicatrix externally used pad pasting, need screen, optimize drug regimen to medicine, can not cause side effect such as allergy during use, not only can be used for the treatment of general groups cicatrix, also be applicable to child and infective wound surface, improve therapeutic effect and expansion treatment colony scope that the gel cicatrix is pasted.
Summary of the invention
In view of this, the purpose of this invention is to provide a kind of anti-cicatrix externally used pad pasting that contains anti-mastocyte class medicine and preparation method thereof, pad pasting can not cause allergic reaction when using, the treatment phase is used the change that atrophoderma, telangiectasis, pigmentation and secondary infection can not occur and can not cause patient's hormonal readiness, not only can be used for the treatment of general groups cicatrix, also be applicable to the child and remove the wound surface of severe infections, improve the therapeutic effect that the gel cicatrix pastes and enlarge treatment colony scope.
The anti-cicatrix externally used pad pasting that contains anti-mastocyte class medicine of the present invention comprises silicon gel medicine rete, and silicon gel medicine rete is added with anti-mastocyte class medicine.
Further, silicon gel medicine rete also is added with hormone medicine;
Further, the content of hormone medicine is 0.01-1mg in every square centimeter of described silicon gel medicine rete, and anti-mastocyte class content of medicines is 0.1-10mg;
Further, also add the chlorobutanol of 0.1-10mg in every square centimeter of silicon gel medicine rete;
Further, also add the Ca of 0.01-1mg in every square centimeter of described silicon gel medicine rete
2+Antagonism class medicine;
Further, the content of hormone medicine is 0.1mg in every square centimeter of described silicon gel medicine rete, and anti-mastocyte class content of medicines is 0.5mg, Ca
2+Antagonism class content of medicines is 0.1mg, and the content of chlorobutanol is 0.5mg;
Further, described hormone medicine is vinegar third methyl meticortelone or betamethasone, and anti-mastocyte class medicine is a tranilast;
Further, described hormone medicine is vinegar third methyl meticortelone or betamethasone, and anti-mastocyte class medicine is a tranilast, Ca
2+Antagonism class medicine is nimodipine or nitrendipine;
Further, described silicon gel medicine rete is a silicon gel pressure-sensitive adhesive layer, and pressure-sensitive adhesive layer is outside equipped with the silica gel backing layer.
Another object of the present invention is to provide a kind of above-mentioned preparation method that contains the anti-cicatrix externally used pad pasting of anti-mastocyte class medicine of making, may further comprise the steps:
(1) in groove shape mould with the silica gel backing 50-100 ℃ of following film forming;
(2) get anti-mastocyte class medicine and other required medicine of requirement;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the mixture vacuum or the ultrasonic vibrations aerofluxus of step (3);
(5) spare 50-100 ℃ of following film forming adding above the silica gel backing in the adding of the silicon gel pressure sensitive adhesive after the aerofluxus groove shape mould;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain finished product.
The invention has the beneficial effects as follows: the anti-cicatrix externally used pad pasting that contains anti-mastocyte class medicine of the present invention adds hormones and anti-mastocyte class medicine in the pad pasting of prior art, during treating, can not cause the change of patient's hormonal readiness, and add and use chlorobutanol, the cicatrix of non-severe infections wound surface also can be used, reduce the ADR of hormone triamcinolone acetonide, can not cause allergic reaction during use, the interior use of the phase course of treatment atrophoderma, telangiectasis, pigmentation and secondary infection can not occur and can not cause the change of patient's hormonal readiness; Not only can be used for the treatment of general groups cicatrix, also be applicable to the child and remove the wound surface of severe infections, improve the therapeutic effect that the gel cicatrix pastes and enlarge treatment colony scope.Present clinical and experimental studies results shows that effect of the present invention obviously is better than simple silicon gel cicatrix and pastes, and pasting invalid patient for simple silicon gel cicatrix has therapeutic effect too.The preparation technology of anti-cicatrix externally used pad pasting of the present invention is simple, and cost is low.
Description of drawings
Below in conjunction with drawings and Examples the present invention is further described.
Accompanying drawing is a structural representation of the present invention.
The specific embodiment
Accompanying drawing is a structural representation of the present invention, as shown in the figure, silicon gel pressure sensitive adhesive medicine rete 2 outer surfaces are provided with silica gel backing layer 1, and another surface is stained with antiseized ply of paper 3, during use antiseized ply of paper 3 is peeled off, do not had the surface of silica gel backing layer 1 to be affixed on the affected part silicon gel pressure sensitive adhesive medicine rete 2.
Following examples medicament contg all is one square centimeter of medicament contg on the pad pasting.
Embodiment one
(1) in groove shape mould, silica gel is heated to 50 ℃, silica gel is made backing film;
(2) get the tranilast of 0.1mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 50 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment two
(1) in groove shape mould, silica gel is heated to 80 ℃, silica gel is made backing film;
(2) get the tranilast of 0.5mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 80 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment three
(1) in groove shape mould, silica gel is heated to 100 ℃, silica gel is made backing film;
(2) get the tranilast of 10mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 100 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment four
(1) in groove shape mould, silica gel is heated to 50 ℃, silica gel is made backing film;
(2) get vinegar third methyl meticortelone of 0.01mg, the tranilast of 0.1mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 50 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment five
(1) in groove shape mould, silica gel is heated to 80 ℃, silica gel is made backing film;
(2) get vinegar third methyl meticortelone of 0.1mg, the tranilast of 0.5mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 80 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment six
(1) in groove shape mould, silica gel is heated to 100 ℃, silica gel is made backing film;
(2) get the betamethasone of the 1mg of institute, the tranilast of 10mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 100 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment seven
(1) in groove shape mould, silica gel is heated to 80 ℃, silica gel is made backing film;
(2) get vinegar third methyl meticortelone of the 0.01mg of institute, the tranilast of 0.1mg, the chlorobutanol of 0.1mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 80 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment eight
(1) in groove shape mould, silica gel is heated to 80 ℃, silica gel is made backing film;
(2) get the betamethasone of the 0.1mg of institute, the tranilast of 0.5mg, the chlorobutanol of 0.5mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 80 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment nine
(1) in groove shape mould, silica gel is heated to 100 ℃, silica gel is made backing film;
(2) get vinegar third methyl meticortelone of the 1mg of institute, the tranilast of 10mg, the chlorobutanol of 10mg and the nimodipine of 0.01mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 100 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment ten
(1) in groove shape mould, silica gel is heated to 80 ℃, silica gel is made backing film;
(2) get the betamethasone of the 0.01mg of institute, the tranilast of 0.1mg, the chlorobutanol of 0.1mg, the nimodipine of 0.01mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 100 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment 11
(1) in groove shape mould, silica gel is heated to 100 ℃, silica gel is made backing film;
(2) get vinegar third methyl meticortelone of the 0.01mg of institute, the tranilast of 0.1mg, the chlorobutanol of 0.1mg, the nimodipine of 0.1mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 100 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment 12
(1) in groove shape mould, silica gel is heated to 100 ℃, silica gel is made backing film;
(2) get vinegar third methyl meticortelone of the 0.1mg of institute, the tranilast of 1mg, the chlorobutanol of 0.1mg, the nimodipine of 1mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 100 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment 13
(1) in groove shape mould, silica gel is heated to 100 ℃, silica gel is made backing film;
(2) get vinegar third methyl meticortelone of the 0.1mg of institute, the tranilast of 1mg, the chlorobutanol of 0.1mg, the nitrendipine of 1mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 100 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment 14
(1) in groove shape mould, silica gel is heated to 100 ℃, silica gel is made backing film;
(2) get the betamethasone of the 0.01mg of institute, the tranilast of 0.1mg, the chlorobutanol of 0.1mg, the nitrendipine of 0.1mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 100 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
Embodiment 15
(1) in groove shape mould, silica gel is heated to 80 ℃, silica gel is made backing film;
(2) get vinegar third methyl meticortelone of the 0.01mg of institute, the tranilast of 0.1mg, the chlorobutanol of 0.1mg, the nitrendipine of 0.01mg;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the ultrasonic vibrations aerofluxus of the mixture of step (3);
(5) the silicon gel pressure sensitive adhesive after the aerofluxus is added add above the silica gel backing in the groove shape mould of step (1) and spare 100 ℃ of following film forming;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain the finished product anti-cicatrix externally used pad pasting.
The anti-cicatrix externally used pad pasting that contains anti-mastocyte class medicine of the present invention, experimentize by 30 big ear rabbits of Japan, be equally divided into 3 groups, every group 10, contrast anti-cicatrix externally used pad pasting, simple silicon gel cicatrix are pasted and blank, and the result shows that the former SABC TGF-β, α-SMA expression is starkly lower than other two contrasts.
Clinical patients is tried out 3 examples, shows that pasting simple silicon gel cicatrix pastes invalid patient, and still effective with anti-cicatrix externally used pad pasting, cicatrix continues atrophy, hyperemia is gone down.
Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is had been described in detail with reference to preferred embodiment, those of ordinary skill in the art is to be understood that, can make amendment or be equal to replacement technical scheme of the present invention, and not breaking away from the aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (6)
1. anti-cicatrix externally used pad pasting that contains anti-mastocyte class medicine, comprise silicon gel medicine rete (2), it is characterized in that: silicon gel medicine rete (2) is added with anti-mastocyte class medicine, described anti-mastocyte class medicine is a tranilast, and the content of tranilast is 0.1-10mg in every square centimeter of described silicon gel medicine rete (2); Silicon gel medicine rete (2) also is added with hormone medicine, and described hormone medicine is vinegar third methyl meticortelone or betamethasone; Also add the chlorobutanol of 0.1-10mg in every square centimeter of silicon gel medicine rete (2).
2. the anti-cicatrix externally used pad pasting that contains anti-mastocyte class medicine according to claim 1 is characterized in that: the content of vinegar third methyl meticortelone or betamethasone is 0.01-1mg in every square centimeter of described silicon gel medicine rete (2).
3. the anti-cicatrix externally used pad pasting that contains anti-mastocyte class medicine according to claim 2 is characterized in that: the Ca that also adds 0.01-1mg in every square centimeter of described silicon gel medicine rete
2+Antagonism class medicine, Ca
2+Antagonism class medicine is nimodipine or nitrendipine.
4. the anti-cicatrix externally used pad pasting that contains anti-mastocyte class medicine according to claim 3, it is characterized in that: the content of vinegar third radiosone or betamethasone is 0.1mg in every square centimeter of described silicon gel medicine rete (2), the content of tranilast is 0.5mg, the content of nimodipine or nitrendipine is 0.1mg, and the content of chlorobutanol is 0.5mg.
5. the anti-cicatrix externally used pad pasting that contains anti-mastocyte class medicine according to claim 4 is characterized in that: described silicon gel medicine rete (2) is a silicon gel pressure-sensitive adhesive layer, and pressure-sensitive adhesive layer is outside equipped with silica gel backing layer (1).
6. preparation method that contains the anti-cicatrix externally used pad pasting of anti-mastocyte class medicine may further comprise the steps:
(1) in groove shape mould with the silica gel backing 50-100 ℃ of following film forming;
(2) get tranilast and vinegar third methyl meticortelone or the betamethasone of requirement;
(3) in silicon gel pressure sensitive adhesive, add step (2) medicine mechanical agitation mix homogeneously;
(4) with the mixture vacuum or the ultrasonic vibrations aerofluxus of step (3);
(5) spare 50-100 ℃ of following film forming adding above the silica gel backing in the adding of the silicon gel pressure sensitive adhesive after the aerofluxus groove shape mould;
(6) pressure sensitive adhesive laminating separate paper and pack the back radiosterilization obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100926950A CN101152164B (en) | 2007-09-14 | 2007-09-14 | Anti-cicatrix externally used pad pasting containing anti-hypertrophy cell medicament and method for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100926950A CN101152164B (en) | 2007-09-14 | 2007-09-14 | Anti-cicatrix externally used pad pasting containing anti-hypertrophy cell medicament and method for preparing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101152164A CN101152164A (en) | 2008-04-02 |
| CN101152164B true CN101152164B (en) | 2011-04-06 |
Family
ID=39254184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100926950A Expired - Fee Related CN101152164B (en) | 2007-09-14 | 2007-09-14 | Anti-cicatrix externally used pad pasting containing anti-hypertrophy cell medicament and method for preparing the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101152164B (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2273179Y (en) * | 1996-08-02 | 1998-01-28 | 重庆西南医院 | Anti-scar silicate gel film |
| EP1177786A1 (en) * | 2000-03-07 | 2002-02-06 | Teijin Limited | Stretchable patch |
| CN1081030C (en) * | 1996-02-07 | 2002-03-20 | 立德化学株式会社 | External preparation containing tranilast and process for producing the same |
| CN1363276A (en) * | 2001-11-20 | 2002-08-14 | 舒国权 | Exterior-applied medicine 'Shufushan' for treating dermatopathy |
| CN1520792A (en) * | 2003-02-13 | 2004-08-18 | 上海东月医疗保健用品有限公司 | Filling type fortified scar plaster and method for making same |
| CN1194679C (en) * | 2001-04-28 | 2005-03-30 | 沈阳药科大学 | External Tranilast lipid gel prepn and its prepn process |
| CN1729986A (en) * | 2005-08-12 | 2006-02-08 | 中国人民解放军第三军医大学第二附属医院 | A kind of anti-scar drug film and preparation method thereof |
| CN1738599A (en) * | 2001-08-16 | 2006-02-22 | 艾克塞斯制药公司 | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
-
2007
- 2007-09-14 CN CN2007100926950A patent/CN101152164B/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081030C (en) * | 1996-02-07 | 2002-03-20 | 立德化学株式会社 | External preparation containing tranilast and process for producing the same |
| CN2273179Y (en) * | 1996-08-02 | 1998-01-28 | 重庆西南医院 | Anti-scar silicate gel film |
| EP1177786A1 (en) * | 2000-03-07 | 2002-02-06 | Teijin Limited | Stretchable patch |
| CN1194679C (en) * | 2001-04-28 | 2005-03-30 | 沈阳药科大学 | External Tranilast lipid gel prepn and its prepn process |
| CN1738599A (en) * | 2001-08-16 | 2006-02-22 | 艾克塞斯制药公司 | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
| CN1363276A (en) * | 2001-11-20 | 2002-08-14 | 舒国权 | Exterior-applied medicine 'Shufushan' for treating dermatopathy |
| CN1520792A (en) * | 2003-02-13 | 2004-08-18 | 上海东月医疗保健用品有限公司 | Filling type fortified scar plaster and method for making same |
| CN1729986A (en) * | 2005-08-12 | 2006-02-08 | 中国人民解放军第三军医大学第二附属医院 | A kind of anti-scar drug film and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 樊东力,等.硅凝胶膜对增生性瘢痕组织的影响机制.第四军医大学学报20 11.1999,20(11),999-1002. |
| 樊东力,等.硅凝胶膜对增生性瘢痕组织的影响机制.第四军医大学学报20 11.1999,20(11),999-1002. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101152164A (en) | 2008-04-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1976655A (en) | System and method for providing therapy to an individual | |
| US7063859B1 (en) | Barrier film lined backing layer composition and method for topical administration of active agents | |
| WO2012029127A1 (en) | Skin patch sheet, utilization of same, and method for applying skin patch sheet | |
| CA2894933C (en) | Topical co-enzyme q10 formulations and treatment of pain, fatigue and wounds | |
| SG184181A1 (en) | Transdermal delivery patch | |
| CN106456569A (en) | Device for delivery of skin care composition | |
| CN101152163B (en) | Anti-cicatrix externally used pad pasting containing hormone medicament and method for preparing the same | |
| WO2007077640A1 (en) | Skin patch and method of producing the same | |
| JP2010163367A (en) | Patch and patch preparation | |
| TWM329426U (en) | Pharmacy patch | |
| JPH06296702A (en) | Hydrogel applicator and its production | |
| CN101152164B (en) | Anti-cicatrix externally used pad pasting containing anti-hypertrophy cell medicament and method for preparing the same | |
| JPH09124468A (en) | Plaster for exodermis enclosing medicine | |
| JP2013255856A (en) | Plaster body sheet | |
| CN1839798A (en) | Thin plaster, plaster thinning making method and apparatus | |
| CN201213915Y (en) | Magnetic sheet implanted plaster | |
| Piquero-Casals et al. | Using oral tetracycline and topical betamethasone valerate to treat acrodermatitis continua of Hallopeau | |
| WO2005034854A2 (en) | Water dispersible film | |
| CN215194966U (en) | Acupuncture point application convenient to use | |
| JPH09301853A (en) | Plaster and plaster preparation | |
| JPS61267512A (en) | Laminated structure | |
| CN207412303U (en) | A kind of disposable drug nursing plaster for site of injury | |
| US20240050361A1 (en) | Topical product hands-free applicator drug delivery system and methods of making and using the same | |
| JP5384730B2 (en) | Patch sheet | |
| CN211705035U (en) | Injection type band-aid with medicament |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110406 Termination date: 20150914 |
|
| EXPY | Termination of patent right or utility model |