CN101146558B - 医学治疗装置及其制造方法 - Google Patents
医学治疗装置及其制造方法 Download PDFInfo
- Publication number
- CN101146558B CN101146558B CN2005800492838A CN200580049283A CN101146558B CN 101146558 B CN101146558 B CN 101146558B CN 2005800492838 A CN2005800492838 A CN 2005800492838A CN 200580049283 A CN200580049283 A CN 200580049283A CN 101146558 B CN101146558 B CN 101146558B
- Authority
- CN
- China
- Prior art keywords
- coating
- inhibitor
- fixative
- activating enzymes
- treatment device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 21
- 238000000576 coating method Methods 0.000 claims abstract description 91
- 239000011248 coating agent Substances 0.000 claims abstract description 90
- 239000000758 substrate Substances 0.000 claims abstract description 32
- 230000002785 anti-thrombosis Effects 0.000 claims abstract description 28
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims abstract description 24
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims abstract description 24
- 229960005356 urokinase Drugs 0.000 claims abstract description 24
- 229920000669 heparin Polymers 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 20
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229960002897 heparin Drugs 0.000 claims abstract description 18
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 14
- 239000000057 synthetic resin Substances 0.000 claims abstract description 14
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 13
- 229920002614 Polyether block amide Polymers 0.000 claims abstract description 12
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims abstract description 11
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000004677 Nylon Substances 0.000 claims abstract description 9
- 229920001577 copolymer Polymers 0.000 claims abstract description 9
- 229920001778 nylon Polymers 0.000 claims abstract description 9
- 229920002635 polyurethane Polymers 0.000 claims abstract description 9
- 239000004814 polyurethane Substances 0.000 claims abstract description 9
- 238000004519 manufacturing process Methods 0.000 claims abstract description 8
- 239000003960 organic solvent Substances 0.000 claims abstract description 8
- 102000004190 Enzymes Human genes 0.000 claims description 41
- 108090000790 Enzymes Proteins 0.000 claims description 41
- 230000003213 activating effect Effects 0.000 claims description 41
- 229940088598 enzyme Drugs 0.000 claims description 41
- 239000003112 inhibitor Substances 0.000 claims description 41
- 239000003146 anticoagulant agent Substances 0.000 claims description 33
- 239000000834 fixative Substances 0.000 claims description 33
- 230000020764 fibrinolysis Effects 0.000 claims description 32
- 239000003513 alkali Substances 0.000 claims description 15
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 12
- 238000004090 dissolution Methods 0.000 claims description 10
- 239000012744 reinforcing agent Substances 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 7
- 238000007598 dipping method Methods 0.000 claims description 6
- 101710145505 Fiber protein Proteins 0.000 claims description 5
- 108010088842 Fibrinolysin Proteins 0.000 claims description 5
- 102000007625 Hirudins Human genes 0.000 claims description 5
- 108010007267 Hirudins Proteins 0.000 claims description 5
- 108010023197 Streptokinase Proteins 0.000 claims description 5
- 102000012607 Thrombomodulin Human genes 0.000 claims description 5
- 108010079274 Thrombomodulin Proteins 0.000 claims description 5
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 claims description 5
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 claims description 5
- 230000000702 anti-platelet effect Effects 0.000 claims description 5
- 239000003130 blood coagulation factor inhibitor Substances 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000000835 fiber Substances 0.000 claims description 5
- 229940001501 fibrinolysin Drugs 0.000 claims description 5
- 229940006607 hirudin Drugs 0.000 claims description 5
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 229960005202 streptokinase Drugs 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 229960000187 tissue plasminogen activator Drugs 0.000 claims description 5
- 238000004873 anchoring Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 229920001971 elastomer Polymers 0.000 abstract description 3
- 239000000806 elastomer Substances 0.000 abstract description 3
- 229920000915 polyvinyl chloride Polymers 0.000 abstract 1
- 239000004800 polyvinyl chloride Substances 0.000 abstract 1
- SBHRWOBHKASWGU-UHFFFAOYSA-M tridodecyl(methyl)azanium;chloride Chemical group [Cl-].CCCCCCCCCCCC[N+](C)(CCCCCCCCCCCC)CCCCCCCCCCCC SBHRWOBHKASWGU-UHFFFAOYSA-M 0.000 abstract 1
- 235000019602 lubricity Nutrition 0.000 description 23
- 238000012360 testing method Methods 0.000 description 21
- 239000000243 solution Substances 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- 239000008280 blood Substances 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 11
- 238000011010 flushing procedure Methods 0.000 description 11
- 208000007536 Thrombosis Diseases 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 238000005470 impregnation Methods 0.000 description 4
- 238000005461 lubrication Methods 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 239000012670 alkaline solution Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 2
- 229960001008 heparin sodium Drugs 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- DSUFPYCILZXJFF-UHFFFAOYSA-N 4-[[4-[[4-(pentoxycarbonylamino)cyclohexyl]methyl]cyclohexyl]carbamoyloxy]butyl n-[4-[[4-(butoxycarbonylamino)cyclohexyl]methyl]cyclohexyl]carbamate Chemical compound C1CC(NC(=O)OCCCCC)CCC1CC1CCC(NC(=O)OCCCCOC(=O)NC2CCC(CC3CCC(CC3)NC(=O)OCCCC)CC2)CC1 DSUFPYCILZXJFF-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 150000008064 anhydrides Chemical group 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000012783 reinforcing fiber Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/049—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0017—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a surface active agent
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
初始润滑性 | 50次摩擦后的润滑性 | 在温水中浸泡后的润滑性 | |
实施例2 | 00 | 00 | 00 |
对比实施例1到4 | x | x | x |
Claims (19)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2005/002258 WO2006094521A1 (en) | 2005-03-03 | 2005-03-03 | Medical treatment device and method for manufacturing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101146558A CN101146558A (zh) | 2008-03-19 |
CN101146558B true CN101146558B (zh) | 2012-11-07 |
Family
ID=35545619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005800492838A Expired - Fee Related CN101146558B (zh) | 2005-03-03 | 2005-03-03 | 医学治疗装置及其制造方法 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20090306605A1 (zh) |
EP (1) | EP1858563B1 (zh) |
CN (1) | CN101146558B (zh) |
CA (1) | CA2599609C (zh) |
WO (1) | WO2006094521A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5117702B2 (ja) | 2006-10-12 | 2013-01-16 | 日本コヴィディエン株式会社 | 医療用具および医療用具の製造方法 |
CN101885909B (zh) * | 2010-07-08 | 2012-01-25 | 东南大学 | 一种聚氨酯材料的制备工艺 |
JP5690631B2 (ja) * | 2011-03-30 | 2015-03-25 | 日本コヴィディエン株式会社 | 潤滑性を有する医療用具およびその製造方法 |
US10155100B2 (en) | 2014-03-27 | 2018-12-18 | Covidien Lp | Catheter positioning |
CN113384758B (zh) * | 2021-06-18 | 2022-10-04 | 海思盖德(苏州)生物医学科技有限公司 | 抗凝血涂层组合物及其制备方法与应用 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5069899A (en) * | 1989-11-02 | 1991-12-03 | Sterilization Technical Services, Inc. | Anti-thrombogenic, anti-microbial compositions containing heparin |
US5135516A (en) * | 1989-12-15 | 1992-08-04 | Boston Scientific Corporation | Lubricious antithrombogenic catheters, guidewires and coatings |
EP0693293A1 (en) * | 1994-07-07 | 1996-01-24 | Terumo Kabushiki Kaisha | Medical instruments that exhibit surface lubricity when wetted |
CN1229363A (zh) * | 1997-06-18 | 1999-09-22 | 东丽株式会社 | 抗血栓性医疗材料 |
CN1448144A (zh) * | 2003-04-28 | 2003-10-15 | 浙江大学 | 改进生物医用装置表面抗凝血性能的涂层液及涂层法 |
CN1468923A (zh) * | 2002-07-18 | 2004-01-21 | 浙江大学 | 改善生物医用装置生物相容性的医用涂层材料组成 |
CN1545420A (zh) * | 2001-08-20 | 2004-11-10 | ˹��ά˹��ҽҩ����˾ | 外用组合物、外用组合物前体及其制造和使用方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4678660A (en) * | 1984-12-07 | 1987-07-07 | Deseret Medical, Inc. | Thermoplastic polyurethane anticoagulant alloy coating |
US4917686A (en) * | 1985-12-16 | 1990-04-17 | Colorado Biomedical, Inc. | Antimicrobial device and method |
JPH0716410B2 (ja) | 1986-10-13 | 1995-03-01 | ユニチカ株式会社 | 酵素の固定化方法 |
DE4226810C1 (de) * | 1992-08-13 | 1994-01-27 | Theodor Dipl Ing Krall | Schläuche und andere Gegenstände aus Kunststoffen für den medizinischen Bedarf, die von Keimen nicht besiedelbar sind und Verfahren zu ihrer Herstellung |
US5380299A (en) * | 1993-08-30 | 1995-01-10 | Med Institute, Inc. | Thrombolytic treated intravascular medical device |
US5624704A (en) * | 1995-04-24 | 1997-04-29 | Baylor College Of Medicine | Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent |
JP3776194B2 (ja) | 1997-03-14 | 2006-05-17 | ユニチカ株式会社 | 医療用具及びその製造方法 |
US6416546B1 (en) * | 1997-06-04 | 2002-07-09 | Unitika Ltd. | Medical device and production method thereof |
US6673053B2 (en) * | 1999-05-07 | 2004-01-06 | Scimed Life Systems, Inc. | Hydrophilic lubricity coating for medical devices comprising an antiblock agent |
-
2005
- 2005-03-03 US US11/885,307 patent/US20090306605A1/en not_active Abandoned
- 2005-03-03 CA CA2599609A patent/CA2599609C/en not_active Expired - Fee Related
- 2005-03-03 WO PCT/EP2005/002258 patent/WO2006094521A1/en active Application Filing
- 2005-03-03 EP EP05707699.4A patent/EP1858563B1/en not_active Not-in-force
- 2005-03-03 CN CN2005800492838A patent/CN101146558B/zh not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5069899A (en) * | 1989-11-02 | 1991-12-03 | Sterilization Technical Services, Inc. | Anti-thrombogenic, anti-microbial compositions containing heparin |
US5135516A (en) * | 1989-12-15 | 1992-08-04 | Boston Scientific Corporation | Lubricious antithrombogenic catheters, guidewires and coatings |
EP0693293A1 (en) * | 1994-07-07 | 1996-01-24 | Terumo Kabushiki Kaisha | Medical instruments that exhibit surface lubricity when wetted |
CN1229363A (zh) * | 1997-06-18 | 1999-09-22 | 东丽株式会社 | 抗血栓性医疗材料 |
CN1545420A (zh) * | 2001-08-20 | 2004-11-10 | ˹��ά˹��ҽҩ����˾ | 外用组合物、外用组合物前体及其制造和使用方法 |
CN1468923A (zh) * | 2002-07-18 | 2004-01-21 | 浙江大学 | 改善生物医用装置生物相容性的医用涂层材料组成 |
CN1448144A (zh) * | 2003-04-28 | 2003-10-15 | 浙江大学 | 改进生物医用装置表面抗凝血性能的涂层液及涂层法 |
Also Published As
Publication number | Publication date |
---|---|
WO2006094521A1 (en) | 2006-09-14 |
EP1858563B1 (en) | 2016-07-27 |
EP1858563A1 (en) | 2007-11-28 |
CA2599609C (en) | 2013-08-13 |
US20090306605A1 (en) | 2009-12-10 |
CA2599609A1 (en) | 2006-09-14 |
CN101146558A (zh) | 2008-03-19 |
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