CN101138593A - Preparation method of Chinese medicine unction and emplastrum for treating external hemorrhoid (ancient ink ointment for curing piles ) - Google Patents
Preparation method of Chinese medicine unction and emplastrum for treating external hemorrhoid (ancient ink ointment for curing piles ) Download PDFInfo
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- CN101138593A CN101138593A CNA2006101287926A CN200610128792A CN101138593A CN 101138593 A CN101138593 A CN 101138593A CN A2006101287926 A CNA2006101287926 A CN A2006101287926A CN 200610128792 A CN200610128792 A CN 200610128792A CN 101138593 A CN101138593 A CN 101138593A
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- cortex phellodendri
- rhizoma coptidis
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Abstract
The present invention discloses a Chinese ointment and plaster for treating external hemorrhoids with functions of removing heat and drying damp, alleviating pain and itching, arresting bleeding and diminishing swelling. The recipe includes main medicine, auxiliary medicine and matrix, which are made into ointment and then plaster for convenient use. The share by weight of the main medicine includes 1.33-4g muskiness, 2-6g calculus bovis factitious, 6-18g bear gall, 33.3-100g Gumo (duan) and 10-30g borneol; the share by weight after mixing and ultramicro grinding is 52.7-158g. The coarse powder extract of 15-45g gromwell, 13.3-40g gentian and 15-45g corktree is 17.33-52g. The matrix includes 246.7-740g Vaseline and 16.7-50g Lanolin, which are made into 333.43-1000g. The invented Chinese ointment and plaster in the art of hemorrhoids is more standardized and more stable, which overcomes the arbitrariness concoction of general honey or Vaseline, thus affecting the curative effect.
Description
Technical field:
The present invention relates to a kind of effective ingredient that from Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri, extracts with Moschus, artificial Calculus Bovis, Fel Ursi, forge medicated powder that Gu Mo, Borneolum Syntheticum become through airtight micronizing and adopt substrate vaseline, lanoline to be hybridly prepared into to be used for because of the prescription of diseases such as all kinds of hemorrhoid, anal fissure, anal eczema, anus condyloma latum, stool due to the dampness and heat stasis are hemorrhage and make this ointment formulation and the method for plaster dosage form.
Background technology:
The present invention applies to a clinical proved recipe for many years, several times revise for a long time, though the treatment external hemorrhoid is evident in efficacy, but its prescription composition of its formulation method and used substrate all unstable (substrate such as siritch commonly used, Oleum Ricini, vaseline etc.) also has very big randomness, preparation process is lack of standardization, interdependence is poor, thereby has influenced the defective of the performance of Drug therapy effect.So the present invention is according to the requirement of standard preparation technique under the Chinese Pharmacopoeia ointment item, its prescription meets the principles of formulating prescriptions of traditional Chinese medical science monarch, select the substrate (medicinal vaseline, lanoline etc.) that meets the Chinese Pharmacopoeia regulation for use, adopt tradition or modern science and technology to carry out the extraction of active ingredient and micronizing etc. and produce the formulated ancient black ointment for treating hemorrhoid of preparation process technology, it is fast not only to have the mucocutaneous absorption of external application, and therapeutic effect is reliable rapidly.And characteristics such as the ointment steady quality carries with easy to use, and interdependence is good.
Summary of the invention:
Defective at above-mentioned existing preparation technique existence, first purpose of the present invention is to provide a kind of proved recipe, make have heat clearing and damp drying, the prescription that is used for effects such as stool that all kinds of hemorrhoid, anal fissure, anal eczema, anus condyloma latum, internal hemorrhoid due to the dampness and heat stasis cause is hemorrhage of antalgesic-antipruritic, hemostasia and detumescence function.
Second purpose of the present invention is to provide a kind of method of utilizing this pharmaceutical formulation ointment and plaster dosage form.
The technical solution used in the present invention is: a kind ofly have that the heat clearing away bath is wet, the traditional Chinese herb medicine preparation and a plaster dosage form of antalgesic-antipruritic, hemostasia and detumescence effect.Its prescription composition is Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri coarse powder extract.Moschus, artificial Calculus Bovis, Fel Ursi, Gu Mo (forging), Borneolum Syntheticum are through airtight micronizing and adopt substrate vaseline, lanoline mix preparation to form.
Describedly have that the heat clearing away bath is wet, the weight quota of its prescription of external traditional Chinese herb medicine preparation of antalgesic-antipruritic, hemostasia and detumescence effect is: Moschus 1.33～4g, artificial Calculus Bovis 2～6g, Fel Ursi 6～18g, Gu Mo (forging) 33.3～100g, Borneolum Syntheticum 10～30g, Radix Arnebiae (Radix Lithospermi) 15～45g, Rhizoma Coptidis 13.3～40g, Cortex Phellodendri 15～45g, vaseline 246.7～740g, lanoline 16.7～50g.
The weight quota of described this Chinese medicine preparation extract and micronizing fine powder is respectively: the weight quota of Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri extract is 17.33～52g, and the weight quota that Moschus, artificial Calculus Bovis, Fel Ursi, Gu Mo (forging) Borneolum Syntheticum mix micronizing medicated powder is that 52.7～158g, substrate vaseline 246.7～740g, lanoline 16.7～50g make ointment 333.43～1000g.
The mechanism of action:
Ancient black ZHICHUANG GAO shows through clinical application and clinical trial for many years, external application can make the corium blood capillary shrink rapidly around anus, suppress epidermal cell proliferation or regeneration, can suppress fibrocellular new life in the connective tissue, lysosome membrane in the stabilized cell prevents that lysosomal enzyme from discharging caused tissue injury.So this product has stronger antiinflammatory and reducing swelling and alleviating pain itching-relieving action.
Proved recipe China ink in the middle ancient times, Moschus, Calculus Bovis, Fel Ursi have the effect of putrefaction removing and tissue regeneration promoting, and Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri have more heat clearing and damp drying, the effect of the evacuation of pus of drawing out pus by applying a plaster to the affected part.Adding has refrigerant pleasant Borneolum Syntheticum in the side, and inflammation has distinctive feature around treatment external piles skin ulcer and the anus thereof.
Preparation process:
Make the technology of this external traditional Chinese herb medicine preparation and plaster dosage form, can comprise the steps:
Extraction process 1., get Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri respectively coarse pulverization decoct with water three times, 2 hours for the first time, for the second time, the 3rd each 1 hour, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.10 (80 ℃), and adding ethanol, to make its content be 75%, left standstill 24 hours, filter, reclaim ethanol, being concentrated into relative density is thick paste, the drying of 1.36 (80 ℃), is ground into fine powder and is the extract semi-finished product.
Extraction process 2., get Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri respectively coarse pulverization to add an amount of solvent evenly moistening, airtight placement 5 hours, drop into again in the percolator and make solvent with 90% ethanol, surpass the powder dipping after 24 hours, with the speed of per minute 2～3ml percolation slowly, collect the liquid 850ml device preservation in addition of just filtering, continue percolation to the liquid of filtering near till colourless, (during must constantly stir squeezing make active ingredient is able to abundant extraction in the medical material) collects the continuous liquid of filtering, recovered alcohol is 1.30 paste semi-finished product for standby being condensed into relative density below 60 ℃.
Extraction process 3., ultrasonic extraction: get the coarse pulverization respectively of Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri, put in the supersound extraction equipment.Add 90% ethanol 1000ml, flooded 24 hours, supersound process 30～60 minutes, recovered alcohol is that 1.30 paste is standby being condensed into relative density below 60 ℃.
Fire forge technology 4., get that Gu Mo is packaged to go in the pottery altar, again the pottery altar is put into the stove fire moderate heat and was forged 30 minutes, make it the aglow degree that is.Cool taking-up, its glossiness is disappeared and apparent loose getting final product.It is standby to be broken into fine powder through the ancient black piece superfine powder that fire is forged into loose shape.
Micronizing technology 5., get Moschus, artificial Calculus Bovis, the accurate weighing of Fel Ursi, mixing airtight superfine powder, to be broken into fine powder standby.Get the accurate weighing of Borneolum Syntheticum, porphyrize device is in addition preserved, and drops at last during preparation ointment, and stirring gets final product.
The finished product preparation process 6., get Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri extract and the accurate weighing of the black fine powder of above-mentioned Gu, put in the mixer and stir, get vaseline 246.7～740g, lanoline 16.7～50g, heating, filtration are put and are chilled to about 50 ℃, add fine powders such as Moschus, fully stir, at last Borneolum Syntheticum is dissolved the back with an amount of ethanol and drop into, be stirred to ointment and partly solidify shape, make 333.43～1000g promptly.
The emplastrum preparation process 7., use this product easily and effectively for making hemorrhoid patients specially is made into the plaster dosage form with Manufactured ointment.
1., a kind of lamellar emplastrum of requiring this ointment and suitable macromolecular material to make preparation method is:.Mainly by backing layer, medicine storing layer, adhesive-layer and adherent layer are formed.2., the back lining materials that adopts of this product has cotton, non-woven fabrics etc., lid lining material commonly used has separate paper, plastic sheeting, aluminium foil, polyethylene composite film, or hard gauze etc.3., this product can adopt thermoplastic rubber, medical zinc oxide etc.4., the size specification of this product and the ratio of coating the ointment formulation amount of making on the back lining materials, all can press under the anus emplastrum item related standards and make.
Products characteristics: this ointment formulation is blackish green or black, gas perfume (or spice), band mint flavored.Around being coated on anus refrigerant comfort is arranged promptly, clinical for many years having no side effect and the untoward reaction performance liked by all kinds of hemorrhoid patients deeply.Its extract is promptly water-soluble, also is dissolved in ethanol, with substrate vaseline, lanoline interaction efficacy stability.
More than be preferred embodiment of the present invention, all changes of doing according to technical solution of the present invention when the function that is produced does not exceed the scope of technical solution of the present invention, all belong to protection scope of the present invention.
Claims (6)
1. Chinese medicine for outer use with heat clearing and damp drying, antalgesic-antipruritic, hemostasia and detumescence effect.Be used for the treatment of scorching, anus condyloma latum around inside and outside mixed hemorrhoid due to the dampness and heat stasis, anal eczema, the anus, and anal fissure disease sees that stool is hemorrhage, bearing down or pain etc. are arranged.
1., the Chinese medicine preparation dosage form of treatment external piles skin ulcer is (ointment) it is characterized in that:; with the plaster dosage form; make by principal agent and accessory drugs; described principal agent is Moschus, artificial Calculus Bovis, Fel Ursi; accessory drugs is extract, a Borneolum Syntheticum porphyrize powder of forging Gu Mo (powder), Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri; mix homogeneously adds substrate vaseline, lanoline stirs promptly.
2. the Chinese medicine for outer use with heat clearing and damp drying, antalgesic-antipruritic, hemostasia and detumescence effect according to claim 1, it is characterized in that: the weight quota of described prescription is respectively: Moschus 1.33～4g, artificial Calculus Bovis 2～6g, Fel Ursi 6～18g, Gu Mo (forging) 33.3～100g, Radix Arnebiae (Radix Lithospermi) 15～45g, Rhizoma Coptidis 13.3～40g, Cortex Phellodendri 15～45g, Borneolum Syntheticum 10～30g, vaseline 246.7～740g, lanoline 16.7～50g.
3. the Chinese medicine for outer use with heat clearing and damp drying, antalgesic-antipruritic, hemostasia and detumescence effect according to claim 2, it is characterized in that: before the preparation, earlier Gu Mohuo is forged the process of preparing Chinese medicine, method is: ancient China ink is packed in the pottery altar, again the pottery altar is placed in the cooking stove and burnt 30 minutes, make it the aglow degree that is.Cool taking-up, its gloss is disappeared and apparent loose getting final product, it is broken into fine powder through superfine powder.In addition with Moschus, artificial Calculus Bovis, Fel Ursi, that the airtight superfine powder of mixing is broken into fine powder is standby, Borneolum Syntheticum porphyrize device is in addition preserved standby.With Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri adopt 1., decocting method extracts active ingredient, 2., the dipping percolation extracts active ingredient, 3., ultrasonic method extracts active ingredient.
4. the Chinese medicine for outer use with heat clearing and damp drying, antalgesic-antipruritic, hemostasia and detumescence effect according to claim 3; it is characterized in that: will concoct the ancient ink powder of forging of back micronizing by the processing of Chinese medicine tradition; and airtight superfine powder is broken into Moschus, artificial Calculus Bovis, Fel Ursi, Borneolum Syntheticum fine powder and Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, the Cortex Phellodendri extract mix homogeneously of fine powder, adds vaseline, lanoline stirs promptly.
5. the Chinese medicine for outer use with heat clearing and damp drying, antalgesic-antipruritic, hemostasia and detumescence effect according to claim 4, it is characterized in that: the weight quota of described active ingredient is that Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri extract are equivalent to 2: 5 ratio, and promptly crude drug 5g is equivalent to extract 2g.And Moschus, artificial Calculus Bovis, Fel Ursi, forge ancient ink powder, the weight quota of Borneolum Syntheticum (micronizing) mixed powder is 52.7～158g.The weight quota of Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri extract is 17.33～52g, substrate vaseline 246.7～740g, lanoline 16.7～50g, and mixing and stirring is made 333.43～1000g promptly.
6. the Chinese medicine for outer use with heat clearing and damp drying, antalgesic-antipruritic, hemostasia and detumescence effect according to claim 5.Make the method for this traditional Chinese herb medicine preparation and emplastrum, it is characterized in that following steps:
Extract 1., get Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri coarse pulverization respectively, decoct with water three times, 2 hours for the first time, for the second time, each 1 hour for the third time, collecting decoction, filtration, filtrate is concentrated into the clear paste of relative density 1.10 (80 ℃), adding ethanol, to make content be 75%, left standstill 24 hours, filters, recovered alcohol is concentrated into the thick paste that relative density is 1.36 (80 ℃), and is dry, to be ground into fine powder standby.
Extract 2., get Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri coarse pulverization respectively, it is evenly moistening to add an amount of solvent, and airtight placement 5 hours reinstalls in the percolator and makes solvent with 90% ethanol, surpass powder dipping 24 hours, with the speed of per minute 2～3ml percolation slowly, collect the liquid 850ml that just filters, device is preserved in addition, continue percolation to the liquid of filtering near till colourless, collecting the continuous liquid of filtering, reclaim ethanol, is that 1.30 paste is standby being condensed into relative density below 60 ℃.
Extract 3., ultrasonic extraction: get Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Cortex Phellodendri coarse pulverization respectively, put in the supersound extraction equipment, add 90% ethanol 1000ml, flooded 24 hours, supersound process 30～60 minutes, recovered alcohol is that 1.30 paste is standby being condensed into relative density below 60 ℃.
Micronizing 4., get Moschus, artificial Calculus Bovis, the accurate weighing of Fel Ursi, mix that to put in the micronizing equipment airtight pulverizing standby.With the device preservation in addition of the accurate weighing porphyrize of Borneolum Syntheticum, drop at last during preparation ointment, stirring gets final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101287926A CN101138593A (en) | 2006-09-08 | 2006-09-08 | Preparation method of Chinese medicine unction and emplastrum for treating external hemorrhoid (ancient ink ointment for curing piles ) |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2006101287926A CN101138593A (en) | 2006-09-08 | 2006-09-08 | Preparation method of Chinese medicine unction and emplastrum for treating external hemorrhoid (ancient ink ointment for curing piles ) |
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| CN101138593A true CN101138593A (en) | 2008-03-12 |
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| CNA2006101287926A Pending CN101138593A (en) | 2006-09-08 | 2006-09-08 | Preparation method of Chinese medicine unction and emplastrum for treating external hemorrhoid (ancient ink ointment for curing piles ) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829153A (en) * | 2010-05-25 | 2010-09-15 | 耿福能 | American cockroach medicament composition for treating piles and anal fissure and preparation method thereof |
| CN114931457A (en) * | 2022-05-13 | 2022-08-23 | 王德普 | Top anus device and top anus trousers |
-
2006
- 2006-09-08 CN CNA2006101287926A patent/CN101138593A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829153A (en) * | 2010-05-25 | 2010-09-15 | 耿福能 | American cockroach medicament composition for treating piles and anal fissure and preparation method thereof |
| CN114931457A (en) * | 2022-05-13 | 2022-08-23 | 王德普 | Top anus device and top anus trousers |
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Open date: 20080312 |