CN101134104A - Particle medicinal granules for treating pharyngitis and method of producing the same - Google Patents
Particle medicinal granules for treating pharyngitis and method of producing the same Download PDFInfo
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- CN101134104A CN101134104A CNA200710112813XA CN200710112813A CN101134104A CN 101134104 A CN101134104 A CN 101134104A CN A200710112813X A CNA200710112813X A CN A200710112813XA CN 200710112813 A CN200710112813 A CN 200710112813A CN 101134104 A CN101134104 A CN 101134104A
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- pharyngitis
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- radix
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- 201000007100 Pharyngitis Diseases 0.000 title claims abstract description 20
- 239000008187 granular material Substances 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims description 6
- 239000002245 particle Substances 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 23
- 239000004375 Dextrin Substances 0.000 claims abstract description 4
- 229920001353 Dextrin Polymers 0.000 claims abstract description 4
- 235000019425 dextrin Nutrition 0.000 claims abstract description 4
- 102000016943 Muramidase Human genes 0.000 claims description 7
- 108010014251 Muramidase Proteins 0.000 claims description 7
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 7
- 239000004325 lysozyme Substances 0.000 claims description 7
- 229960000274 lysozyme Drugs 0.000 claims description 7
- 235000010335 lysozyme Nutrition 0.000 claims description 7
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims description 6
- 241000959626 Calvatia Species 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 13
- 230000008961 swelling Effects 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 5
- 230000006870 function Effects 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 241000596154 Belamcanda Species 0.000 abstract 1
- 241000133231 Marshallia caespitosa Species 0.000 abstract 1
- 240000005001 Paeonia suffruticosa Species 0.000 abstract 1
- 235000003889 Paeonia suffruticosa Nutrition 0.000 abstract 1
- 235000014676 Phragmites communis Nutrition 0.000 abstract 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 abstract 1
- 240000003582 Platycodon grandiflorus Species 0.000 abstract 1
- 238000007605 air drying Methods 0.000 abstract 1
- 238000012856 packing Methods 0.000 abstract 1
- 238000005453 pelletization Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 5
- 230000003467 diminishing effect Effects 0.000 description 5
- 230000001717 pathogenic effect Effects 0.000 description 4
- 210000003800 pharynx Anatomy 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 201000010927 Mucositis Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 101000924393 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Vacuolar aminopeptidase 1 Proteins 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 208000016150 acute pharyngitis Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000012568 clinical material Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000007499 fusion processing Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
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- 208000024891 symptom Diseases 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to one kind of granule for treating pharyngitis and its preparation process. The medicine is prepared with 13 kinds of Chinese medicinal materials, including belamcanda rhizome, puffball, reed rhizome, tree peony bark, balloonflower root, etc in certain weight proportion, and through sorting material, washing, air drying, mixing, crushing, adding proper amount of dextrin and sugar, pelletizing and packing. It has the functions of clearing away heat and toxic material, reducing pharyngeal swelling, and obvious curative effect, especially on chronic pharyngitis.
Description
Affiliated technical field
The present invention relates to a kind of dissolved granule and manufacture method thereof, more specifically be a kind of dissolved granule that is used for the treatment of pharyngitis and preparation method thereof.
Background technology
Pharyngitis is a kind of commonly encountered diseases, and chronic and acute branch is arranged, and mainly is the pharyngeal mucosa inflammation.Be mainly in the adult, cardinal symptom is pharyngeal discomfort, and foreign body sensation is arranged, and always feels the pharyngeal thing that has pharynx can not tell again down, the irritative cough, dry, swell, obstruction, pruritus etc., but pharyngalgia is arranged seldom.The thickness expectorant piece that often spues early morning easily causes nausea.Treatment adopts Western medicine antiphlogistic treatment curative effect obvious to acute pharyngitis at present, but the chronic pharyngitis western medicine therapy is not had the radical cure way.The many employing tcm therapies or the combination of Chinese and Western medicine, more satisfactory scheme is local symptomatic treatment, can select Chinese patent medicine for use, looses as LIYANLING, Herba Pileae Scriptae Tabellae, security personnel etc., can cooperate the drink of making tea simultaneously: Flos Lonicerae, Radix Ophiopogonis, Semen Sterculiae Lychnophorae, Radix Glycyrrhizae each etc. component, boiled water brews and is taken in small doses at short intervals.But above-mentioned therapeutic scheme therapeutic effect is also not ideal.
Summary of the invention
The present invention seeks to addressing the aforementioned drawbacks,, develop a kind of Chinese medicine granule of swallowing with heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling by the theory of Chinese medical science viewpoint.
The present invention is achieved in that a kind of dissolved granule for the treatment of pharyngitis, and it is as follows that its medicine is formed the weight ratio scope: golden lantern 8～10 grams, Rhizoma Belamcandae 8～10 grams, Lasiosphaera Seu Calvatia 8～10 grams, Rhizoma Phragmitis 11～13 grams, Cortex Moutan 11～13 grams, Radix Platycodonis 11～13 grams, Fructus Arctii (parched) 8～10 grams, Radix Scrophulariae 11～13 grams, restrain Radix Ophiopogonis 11～13, Rhizoma Alismatis 11～13 grams, Rhizoma Acori Graminei 11～13 grams, Herba Dendrobii 11～13 grams, lysozyme 45～55 grams
The medicine components weight ratio of the best proportioning of this dissolved granule is: golden lantern 9 grams, Rhizoma Belamcandae 9 grams, Lasiosphaera Seu Calvatia 9 grams, Rhizoma Phragmitis 12 grams, Cortex Moutan 12 grams, Radix Platycodonis 12 grams, Fructus Arctii (parched) 9 grams, Radix Scrophulariae 12 grams, restrain Radix Ophiopogonis 12, Rhizoma Alismatis 12 grams, Rhizoma Acori Graminei 12 grams, Herba Dendrobii 12 grams, lysozyme 50 grams.
The manufacture method of the dissolved granule of above-mentioned treatment pharyngitis is: earlier with selection of crude drugs, clean, dry, then with drug component by desired weight ratio compatibility, pulverize, add suitable dextrin and sugar again and carry out pelletize, be distributed into bag at last, every bag 15 gram.It is thin more good more to pulverize theoretically, and carrying out the broken purpose of fine powder is that the pars fibrosa in the Chinese medicine ingredients is fully destroyed, thereby increases particulate palatability, also can increase the stripping property of effective ingredient.
Theory of Chinese medical science thinks that throat is the door of lung stomach, and pyretic toxicity is stopped up and to be tied in pulmonary, the smoked throat that burns, and stagnation of QI-blood, the heat meat corruption of burning, red swelling and pain of throat then, even become dense; Be equivalent to acute (suppurative) pharyngitis in the modern medicine.Golden lantern in the prescription, Rhizoma Belamcandae, Lasiosphaera Seu Calvatia, Fructus Arctii (parched) have the effect of heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling; Cortex Moutan, Radix Scrophulariae have the effect of clearing away heat and cooling blood, blood stasis dispelling, mass dissipating and swelling eliminating; Rhizoma Phragmitis, Radix Platycodonis have the effect of a surname diffusing lung qi, relieving sore throat and diminishing swelling, the evacuation of pus of eliminating the phlegm, to reach the pathogenic heat of pent-up; Radix Ophiopogonis, Radix Scrophulariae, Herba Dendrobii have replenishing YIN and removing heat, to reach the effect of nourishing YIN to lower pathogenic fire; Rhizoma Acori Graminei has the effect that removing dampness by means of aromatics is had one's ideas straightened out, calmed the nerves; The effect that Rhizoma Alismatis has promoting diuresis to eliminate damp pathogen, expels the heat-evil makes pathogenic heat have outlet to separate from urine; Lysozyme is the polypeptidase that can decompose mucopolysaccharide that extracts from fresh egg white, be a kind of natural infection material with bactericidal action, and antibiotic, antiviral, hemostasia and detumescence are arranged, and promptly accelerates effects such as organized renewing function, is used for antibiotic, antiviral more.All medicines share has heat-clearing and toxic substances removing, the effect of relieving sore throat and diminishing swelling.
The using method of this medicine is: directly granule dissolved with warm boiled water or elder generation, and oral again, each 1-2 bag.Consider in the fusion process that the fine fibre part in the Chinese medicine ingredients is not dissolved, and has medicinal residues, recommends to use warm boiled water.
Major function of the present invention and beneficial effect are: adopt Chinese medicine material and western modern medicine (lysozyme) combination, manufacturing process is simple, proves through a large amount of clinical uses, has heat-clearing and toxic substances removing, antiinflammatory antiinflammatory, the effect of relieving sore throat and diminishing swelling, be particularly useful for treating chronic pharyngitis, evident in efficacy.
The specific embodiment
With specific embodiment technical characterictic of the present invention is described below.
Embodiment one: golden lantern 9 grams, and Rhizoma Belamcandae 9 grams, Lasiosphaera Seu Calvatia 9 grams, Rhizoma Phragmitis 12 restrains, Cortex Moutan 12 grams, Radix Platycodonis 12 grams, Fructus Arctii (parched) 9 grams, Radix Scrophulariae 12 grams, restrain Radix Ophiopogonis 12, Rhizoma Alismatis 12 grams, Rhizoma Acori Graminei 12 grams, Herba Dendrobii 12 grams, lysozyme 50 grams.
Processing method be earlier with selection of crude drugs, clean, dry, then with drug component by desired weight ratio compatibility, it is broken to carry out fine powder, adds suitable dextrin and sugar again and carries out pelletize, is distributed into bag at last, every bag 15 gram.
Use the dissolved granule of above-mentioned prescription to carry out clinical material observation of curative effect 100 examples, by every day three times each bag take after mixing it with water, statistical result is: invalid 19%, effective 20%, produce effects 61%.
Claims (3)
1. dissolved granule for the treatment of pharyngitis, it is as follows that its medicine is formed weight ratio scope: golden lantern 8～10 grams, Rhizoma Belamcandae 8～10 grams, Lasiosphaera Seu Calvatia 8～10 grams, Rhizoma Phragmitis 11～13 grams, Cortex Moutan 11～13 grams, Radix Platycodonis 11～13 grams, Fructus Arctii (parched) 8～10 grams, Radix Scrophulariae 11～13 grams, restrain Radix Ophiopogonis 11～13, Rhizoma Alismatis 11～13 grams, Rhizoma Acori Graminei 11～13 grams, Herba Dendrobii 11～13 grams, lysozyme 45～55 grams.
2. it is golden lantern 9 grams that a kind of dissolved granule for the treatment of pharyngitis as claimed in claim 1, its medicine are formed weight ratio, penetrates in 9 grams, Lasiosphaera Seu Calvatia 9 grams, Rhizoma Phragmitis 12 grams, Cortex Moutan 12 grams, Radix Platycodonis 12 grams, Fructus Arctii (parched) 9 grams, Radix Scrophulariae 12 grams, restrain Radix Ophiopogonis 12, Rhizoma Alismatis 12 grams, Rhizoma Acori Graminei 12 grams, Herba Dendrobii 12 grams, lysozyme 50 grams.
3. a kind of manufacture method for the treatment of the dissolved granule of pharyngitis as claimed in claim 1 or 2, earlier with selection of crude drugs, clean, dry, then with drug component by desired weight ratio compatibility, pulverize, add suitable dextrin and sugar again and carry out pelletize, be distributed into bag at last.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200710112813XA CN100566749C (en) | 2007-09-03 | 2007-09-03 | A kind of dissolved granule and manufacture method thereof for the treatment of pharyngitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200710112813XA CN100566749C (en) | 2007-09-03 | 2007-09-03 | A kind of dissolved granule and manufacture method thereof for the treatment of pharyngitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101134104A true CN101134104A (en) | 2008-03-05 |
| CN100566749C CN100566749C (en) | 2009-12-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200710112813XA Expired - Fee Related CN100566749C (en) | 2007-09-03 | 2007-09-03 | A kind of dissolved granule and manufacture method thereof for the treatment of pharyngitis |
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| Country | Link |
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| CN (1) | CN100566749C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830601A (en) * | 2014-02-17 | 2014-06-04 | 毛庆云 | Traditional Chinese medicine for treating chronic pharyngitis |
| CN104223076A (en) * | 2014-09-26 | 2014-12-24 | 安徽新津铁皮石斛开发有限公司 | Mango red-jujube-flavored dendrobium officinale granular electuary and preparation method thereof |
| CN106075415A (en) * | 2016-06-30 | 2016-11-09 | 史留喜 | A kind of spray treating pharyngolaryngitis and preparation method thereof |
-
2007
- 2007-09-03 CN CNB200710112813XA patent/CN100566749C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830601A (en) * | 2014-02-17 | 2014-06-04 | 毛庆云 | Traditional Chinese medicine for treating chronic pharyngitis |
| CN104223076A (en) * | 2014-09-26 | 2014-12-24 | 安徽新津铁皮石斛开发有限公司 | Mango red-jujube-flavored dendrobium officinale granular electuary and preparation method thereof |
| CN106075415A (en) * | 2016-06-30 | 2016-11-09 | 史留喜 | A kind of spray treating pharyngolaryngitis and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100566749C (en) | 2009-12-09 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Qingzhou Yao Wang Pharmaceutical Co., Ltd. Assignor: Liu Yuchun Contract fulfillment period: 2009.12.20 to 2014.12.19 contract change Contract record no.: 2010370000047 Denomination of invention: Particle medicinal granules for treating pharyngitis and method of producing the same Granted publication date: 20091209 License type: Exclusive license Record date: 2010.1.29 |
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| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.12.20 TO 2014.12.19; CHANGE OF CONTRACT Name of requester: QINGZHOU YAOWANG PHARMACEUTICAL CO., LTD. Effective date: 20100129 |
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| ASS | Succession or assignment of patent right |
Owner name: QINGZHOU YAOWANG MEDICINE CO., LTD. Free format text: FORMER OWNER: LIU YUCHUN Effective date: 20100628 |
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| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 273100 QUFU PEOPLE HOSPITAL, TIANGUANDI STREET, QUFU CITY, SHANDONG PROVINCE TO: 262500 NO.1, YAOWANGSHAN WEST ROAD, QINGZHOU CITY, SHANDONG PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20100628 Address after: 262500 No. 1 Shanxi Road, Yao Wang, Shandong, Qingzhou Patentee after: Qingzhou Yaowang Pharmaceutical Co., Ltd. Address before: 273100 Qufu Municipal People's Hospital, Tian Ren Jie street, Shandong, Qufu Patentee before: Liu Yuchun |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20091209 Termination date: 20150903 |
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