CN101131386B - Sample analyzer - Google Patents

Sample analyzer Download PDF

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Publication number
CN101131386B
CN101131386B CN 200710142060 CN200710142060A CN101131386B CN 101131386 B CN101131386 B CN 101131386B CN 200710142060 CN200710142060 CN 200710142060 CN 200710142060 A CN200710142060 A CN 200710142060A CN 101131386 B CN101131386 B CN 101131386B
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maintenance
display
during
history
sample
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CN101131386A (en
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藤田教藏
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Sysmex Corp
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Sysmex Corp
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Priority claimed from JP2006225499A external-priority patent/JP4925768B2/en
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Abstract

A analyzer includes a analysis device which can be used for analysis operation and maintenance operation of analysis samples, a memory for storing a maintenance record of the analyzer, an input part for indicating the maintenance implementation of the analyzer, a display, a maintenance history display device which not only displays visually days and weeks but also displays the relative maintenance implementation situation of the day or week, a maintenance operation implementation device which ensures the analysis device to have maintenance operation when receives a indicator from the input part, a maintenance record renewal device for the memory storing maintenance record of the maintenance operation implementation device, a display renewal device for updating maintenance history display after completion of each step of the mantenence operation.

Description

Sample analyzer
Technical field:
The present invention relates to a kind of sample analyzer (the following analyser that also abbreviates as), in particular to a kind of analytical equipment that can show maintenance history or plan.In addition, so-called in this manual " analyser " is a kind ofly not only to comprise the device of samples such as analyzing urine and blood, also comprise such as smearing treating apparatus etc. and analyze the notion of treating apparatus in earlier stage.
Background technology:
The analytical equipment of analyzing samples such as urine and blood will carry out instrument maintenance according to rules (planning chart that comprises maintenance content and date) mainly in order to keep the certain analysis precision.With the blood coagulation analyzer is example, has as Maintenance Significant Items: " cleaning volumetric pipette ", abandon be contained in the discarded case use reaction cup (sample bottle) empty " the discarded sample bottle " of discarded case, with " liquid waste processing " of clean-out system etc., remove attached to " reagent removes and reveals " of the dewfall on the reagent container etc.Maintenance has regular enforcement project and changes consumables, inhales and move sample and reagent, adjustment packing with irregular enforcement projects such as pneumatic supply pressure.
This maintenance existing such as " discarded sample bottle ", " reagent removes and reveals " wait will be under the state of stop device operation user and the maintenance personal project of manually carrying out, the project that need let device move such as " cleaning volumetric pipette " etc. is also arranged.The latter also comprise like " replacing volumetric pipette " though etc. change the manual operation of operation need itself, also have and need start the situation that instrument is changed.Particularly, when " replacing volumetric pipette ", after volumetric pipette being moved to the replacing position, manually completion more changes jobs, need let this volumetric pipette get back to original position.Such as; Patent is openly put down into and is disclosed a kind of automatic analysing apparatus on the 2-150770 communique, its statistics mechanical part running number of times and duration of runs, and the running mechanical part that will add up stored by the time; Judge whether to service time, band did not wait the time band that is suitable for attended operation such as analytical equipment according to memory contents; Be suitable for attended operation time band if be judged as, then send and safeguard commencing signal, carry out attended operation.
In the past, the record of this maintenance was that pure project of manually carrying out or the running instrument project of carrying out all lean on the user on paper (often use on the instrument service manual or subsidiary maintenance record table, or use its copy), to fill in.Patent is openly equalled into 9-No. 211003 communiques and patent and is disclosed to disclose on 2002-No. 181744 communiques and a kind ofly can remember and on display, show the analytical instrument of implementing the maintaining date.
Above-mentioned maintenance record all is attached to instrument operation instructions back mostly with paper, but takes recording method in the past, along with the more and more custom to instrumentation, sees the also fewer and feweri of instructions, may forget record thoroughly.In addition, the operation of analytical instrument and analyze operation and all lean on computing machine such as computer to carry out, the maintenance work of carrying out along with aforesaid operations also is to carry out according to the indication of importing from computing machine.At this moment, the user need safeguard indication to the computing machine input, and after confirming to accomplish this maintaining, fills in above-mentioned paper used for recording, and the record maintenance condition is very loaded down with trivial details.And when the user want when the analysis operation is carried out, to confirm maintaining situation in the past, often paper used for recording brought inconvenience for affirmation work not on hand.
Patent is openly equalled into 9-No. 211003 communiques and patent and is disclosed on 2002-No. 181744 communiques disclosed automatic analytical instrument and when showing maintenance record, can only show and implement the maintaining newest date on the same day; Therefore; The maintenance work that frequent even (such as every day or weekly) implements; The user once can confirm on picture also is up-to-date date of execution, can't confirm the information that several are safeguarded day quickly.Angle from maintenance management; Preferably record implementor-name on the maintenance history; Disclosed automatic analytical instrument will write down the implementer on 9-No. 211003 communiques but patent is openly put down into; Must the user manually import, increased the user and implemented the burden that maintenance work all will be imported the implementer at every turn, and forgotten input easily.
Summary of the invention:
Scope of the present invention is not limit by the statement of this joint summary of the invention on any degree, only by appended claim book defined.
First of sample analyzer of the present invention is characterised in that it comprises:
Store the storer of the maintenance history of this sample analyzer;
Display; And
Display control section, according to the maintenance history of above-mentioned memory stores at the maintenance management interface that shows the maintenance history during being used to be illustrated in several on the display.
Have in the wherein above-mentioned maintenance management interface and distinguish during corresponding respectively to above-mentioned during each several, the district shows maintenance history during this period during each.
The also storage system maintenance plan of said storer, the district shows corresponding maintenance plan during each.
Said display control section is controlled said display, and at said first mark that district's relevant position data representing has been implemented to safeguard during each, when not implementing upkeep operation, data representing is not implemented second mark of upkeep operation when during this period having implemented upkeep operation.
Said display control section said display said during several in zone corresponding during in the zone, show the history of the Maintenance Significant Items of regularly implementing.
Said display control section, also shows to be different from the zone that the said form of expression of distinguishing during several shows maintenance history except that said during several district at said display.
Said display control section shows the date of enforcement upkeep operation with literal for the Maintenance Significant Items of irregular enforcement at said display.
Also comprise the importation of accepting user's input; Wherein when the Maintenance Significant Items of date of implementing upkeep operation and enforcement has been imported in said importation; Said storer can store as said maintenance history being illustrated in the information that this date implemented said Maintenance Significant Items, this maintenance history that said display control unit branch shows according to the said display of the said information updating of said memory stores.
Also comprise according to the user's information of input and carry out authentication, and the decision entering device that whether allows the user to login in said importation;
Wherein, said storer is when said importation has been imported Maintenance Significant Items and implemented the date of upkeep operation, with the user profile of login and Maintenance Significant Items data and the date data corresponding stored of being imported thereof.
When said display control section shows said maintenance history on said display the guide look show date or the week in, also show and each date or week safeguard performance accordingly.
Second of sample analyzer of the present invention is characterised in that it comprises:
Store the storer of this sample analyzer maintenance plan;
Display; And
Display control section, according to the maintenance history of above-mentioned memory stores at the maintenance management interface that shows the maintenance history during being used to be illustrated in several on the display.
Have in the wherein above-mentioned maintenance management interface and distinguish during corresponding respectively to above-mentioned during each several, the district shows maintenance history during this period during each.
Said display control unit spare said display said during several in district corresponding during the district show the Maintenance Significant Items plan of regularly implementing.
Said display control section is said during several district except that showing on said display, also shows to be different from the zone that the said form of expression of distinguishing during several shows maintenance plan.
For the Maintenance Significant Items of irregular enforcement, said display control section shows the target date of implementing upkeep operation at said display with literal.
Also comprise and infer predetermined day predetermined day estimating unit of said maintenance.
Said storer also storage system maintenance is historical;
Estimating unit was inferred said maintenance predetermined day according to the maintenance history of said memory stores in said predetermined day.
The 3rd of sample analyzer of the present invention is characterised in that it comprises:
Implement the analysis operation of analytical specimen and the analytical equipment of attended operation;
Store the storer of the maintenance record of this sample analyzer;
Be used to indicate above-mentioned analytical equipment to implement the importation of attended operation;
Display;
The control aforementioned display device shows and to correspond respectively to district during during several several and the district shows the maintenance history during corresponding during each maintenance history display device;
Receive from above-mentioned importation and control the attended operation device for carrying out said that above-mentioned analytical equipment is implemented this attended operation when attended operation is implemented indication;
Control the record updating device of the maintenance record of the above-mentioned attended operation device for carrying out said enforcement of above-mentioned memory stores; And
The display update device of updating maintenance history display when above-mentioned attended operation is implemented.
Operation interface that said maintenance history display device lets said display show simultaneously to handle upkeep operation and the historical interface that shows maintenance history.
Said maintenance history display device shows that on said operation interface several indications of indicating several service action respectively use figure,
When the attended operation device for carrying out said has carried out selecting said indication with the input of figure the user in above-mentioned importation, let said analytical equipment implement to use the figure relevant maintaining operation with this indication.
The also storage system maintenance plan of said storer,
Said maintenance history display device shows maintenance plan at above-mentioned historical interface with maintenance history.
The input of maintenance record can be accepted in said importation;
The maintenance record of the artificial input of said memory stores.
For the attended operation that said analytical equipment is implemented according to the indication of said importation, forbid artificial input maintenance record.
When having imported predetermined login name, the ban of said artificial input is disengaged.
When said maintenance history display device showed maintenance history on said display, not only guide look showed date or week, also showed the corresponding performance of safeguarding in each date or week.
The 4th of sample analyzer of the present invention is characterised in that it comprises:
Can implement the analysis operation and the analytical equipment of following the operations of upkeep operation of analytical specimen;
Store the storer of the maintenance record of this analyser;
Be used to indicate above-mentioned analytical equipment to implement the importation of the operations of upkeep operation;
Display;
The control aforementioned display device shows and to correspond respectively to district during during several several and the district shows the maintenance history during corresponding during each maintenance history display device;
When the indication of implementing the operations the upkeep operation is received in above-mentioned importation, let above-mentioned analytical equipment implement the device for carrying out said of the operations of this upkeep operation;
When above-mentioned device for carrying out said is accomplished each step of upkeep operation, maintenance record is stored in the record updating device of above-mentioned storer; And
When accomplishing each step of upkeep operation, the display update device of updating maintenance history display.
The 5th of sample analyzer of the present invention is characterised in that it comprises:
Can implement the analysis operation of analytical specimen and the analytical equipment of attended operation;
Store the storer of the maintenance record of this analyser;
Accept the input media of user's input;
Carry out the entering device whether authentication, decision allow the user to login according to the user's information of above-mentioned input media input;
When above-mentioned input media is received the indication of implementing attended operation, let above-mentioned analytical equipment implement the device for carrying out said of safeguarding of attended operation; And
When above-mentioned attended operation is accomplished, the record updating device that the user profile and the maintenance record of login is stored in above-mentioned storer relatively.
The 6th of sample analyzer of the present invention is characterised in that it comprises:
Can implement the analysis operation of analytical specimen and the analytical equipment of attended operation;
Store the storer of the maintenance record of this analyser;
Accept the importation of user's input;
Display;
On aforementioned display device, show and be used for indicating respectively the display device of several indications of several attended operations with figure;
When the user has carried out selecting above-mentioned indication with the input of figure in above-mentioned importation, let above-mentioned analytical equipment carry out the attended operation device for carrying out said of attended operation with figure by this indication; And
The record updating device of the maintenance record of implementing at the above-mentioned attended operation device for carrying out said of above-mentioned memory stores.
Description of drawings:
Fig. 1 is the integrally-built stravismus key diagram of an embodiment of analyser of the present invention.
Fig. 2 is pick-up unit and the plane key diagram of conveyer in the analyser shown in Figure 1.
Fig. 3 is the pick-up unit structured flowchart in the analyser shown in Figure 1.
Fig. 4 is the control device block diagram in the analyser shown in Figure 1.
Fig. 5 is the process flow diagram of analyser analyzing specimen treatment step shown in Figure 1.
Display frame one example that Fig. 6 shows for display.
Fig. 7 shows example for other pages or leaves of operation panel area B in the display frame.
Fig. 8 is the process flow diagram of explanation maintenance history renewal process.
Embodiment:
Specify the embodiment of analyser of the present invention with reference to the accompanying drawings.Fig. 1 is the integrally-built stravismus key diagram of analyser one embodiment of the present invention, and Fig. 2 is the pick-up unit of analyser shown in Figure 1 and the plane key diagram of conveyer, and Fig. 3 is the structured flowchart of the pick-up unit of analyser shown in Figure 1.Fig. 4 is the block diagram of analyser control device shown in Figure 1.
[one-piece construction of analyser]
At first the one-piece construction with regard to the relevant analyser 1 of this embodiment describes.The analyser 1 that an embodiment of the present invention is relevant is to dissolving the quantity of the relevant predetermined substance of function and the device that level of activity is carried out optical detection and analysis, the blood plasma that sample uses with solidifying with line of blood.Analyser 1 adopts setting time method, synthetic substrate method and immunoturbidimetry that sample is carried out optical detection (formal mensuration).The setting time method of in this embodiment, using is a kind of with the assay method of sample process of setting as the change-detection of transmitted light.The mensuration project has PT (prothrombin time), APTT (activated partial thromboplastin time) and Fbg (fibrin commercial weight) etc.Mensuration project as the synthetic substrate method has ATIII etc., and the mensuration project of immunoturbidimetry has D dipolymer and FDP etc.
Above-mentioned analyser 1 is as shown in Figure 1, mainly is connected control device 4 formations as data processing unit by pick-up unit 2, the determination unit that constitutes at the conveyer 3 of these pick-up unit 2 fronts, by the controller 120 (with reference to Fig. 3) of control detection device 2 and conveyer 3 each parts running and with above-mentioned detection device 2 circuit.In this embodiment, above-mentioned conveyer 3 is an one with pick-up unit 2, constituted the part of analyser 1, but this conveyer 3 can be opened also with analyser in 1 minute.Such as, in containing the large scale system of several analysers, can adopt each analyser not assemble conveyer, several analysers are connected the form on the large-scale pipeline.
Control device 4 is made up of PC 401 (PC) etc., and is as shown in Figure 1, and controller 4a, display 4b and keyboard 4c are arranged.Controller 4a can the control detection device 2 with the operation of conveyer 3, and bear the task that the optical information of the sample that pick-up unit 2 is obtained is analyzed.This controller 4a is made up of CPU, ROM, RAM etc.Display 4b is used for the analysis result that display control section 4a obtains, and states the maintenance history of analyser 1 after showing.
Control device 4 can supply the user to use as operation part, makes order according to the user with the operation indication of keyboard 4c input, gives the controller of said determination unit with this command transfer, operation such as let that this determination unit is analyzed.The determination unit controller is the same with above-mentioned controller 4a, is made up of CPU, ROM, RAM etc., and each parts of aforementioned pick-up unit 2 and conveyer 3 are controlled in the order of sending according to control device 4.
Structure with regard to control device 4 describes below.Controller 4a is as shown in Figure 4, mainly is made up of CPU401a, ROM401b, RAM401c, hard disk 401d, reading device 401e, input and output interfaces 401f, communication interface 401g and image output interface 401h.CPU401a, ROM401b, RAM401c, hard disk 401d, reading device 401e, input and output interfaces 401f, communication interface 401g and image output interface 401h are connected through bus 401i.
CPU401a can carry out the computer program that is stored in ROM401b and read the computer program among the RAM401c.After carrying out through CPU401a, computer 401 states the effect of application program 404a performance control device 4.ROM401b is made up of ROM (read-only memory), PROM, EPROM, EEPROM etc., computer program that storage is carried out by CPU401a and used data thereof etc.
RAM401c is made up of SRAM or DRAM etc., is used to read the computer program that is stored in ROM401b and hard disk 401d.Work space in the time of can also carrying out these computer programs as CPU401a.Hard disk 401d is equipped with various computer programs and the required data of computer program that operating system and application program etc. supply CPU401a to carry out.The application program 404a that being used in this embodiment calculated presence of interference material and concentration thereof also is contained in this hard disk 401d.
Reading device 401e is made up of floppy drive, CD-ROM drive or DVD-ROM driver etc., can read the computer program or the data that are stored in pocket storage medium 404.Pocket storage medium 404 stores the application program 404a in this embodiment, and computer 401 can read application program 404a from this pocket storage medium 404, with its hard disk 401d that packs into.
Above-mentioned application program 404a not only can be provided by pocket storage medium 404, also can connect from this electronic communication circuit (no matter wired, wireless) through the electronic communication circuit, can download with the external mechanical that computer 401 is communicated by letter.Such as, above-mentioned application program 404a is stored in the hard disk of the webserver, and computer 401 addressable these servers are downloaded this application program 404a, and hard disk 401d packs into.
Hard disk 401d provides the operating system of graphic user interface such as Windows (registered trademark) that MS produces etc. is housed.In following explanation, the application program 404a in this embodiment all carries out in the aforesaid operations system.Input and output interfaces 401f is by constituting such as parallel interfaces such as serial line interfaces such as USB, IEEE1394, RS-232C, SCSI, IDE, IEEE1284 and the analog signal interface be made up of D/A converter and A/D converter etc.Input and output interfaces 401f meets keyboard 4c, and the user can use keyboard 4c directly to computer 401 input data.
Communication interface 401g is such as being Ethernet (Ethernet, registered trademark).Computer 401 can use between certain communication protocol and the pick-up unit 2 through this communication interface 401g and transmit data.Image output interface 401h is connected with the display 4b that is made up of LCD or CRT etc., will output to display 4b with the corresponding image signal of view data that receives from CPU401a.Display 4b is according to the image signal display image (picture) of input.
Conveyer 3 is used for to pick-up unit 2 blood preparation being provided, and the test tube rack 151 that is about to be loaded with several (this embodiment is 10) test tubes 150 of adorning blood preparation is delivered to the suction pan position 2a (with reference to Fig. 2) of pick-up unit 2.Conveyer 3 has test tube rack rest area 3a and test tube rack harvesting district 3b; Wherein test tube rack rest area 3a is used for placing the be untreated test tube rack 151 of test tube 150 of blood preparation of dress, and test tube rack harvesting district 3b is used to deposit and adorns the test tube rack 151 of the test tube 150 of processing blood sample.
Pick-up unit 2 carries out optical detecting through the blood preparation that conveyer 3 is provided, and can obtain the optical information of relevant this sample.In this embodiment, blood preparation was installed in the reaction cup 152 (with reference to Fig. 2) of pick-up unit 2 from the test tube that is placed on conveyer 3 test tube racks 151 in 150 minutes, this blood preparation is carried out optical detecting.Pick-up unit 2 glass feeding mechanism 10 that responds, transports rotating disk 20, sample packing arm 30, HIL detecting device 40, lighting unit 50, two reagent packing arms 60, reaction cup forwarder 70, detecting unit 80, urgent injector 90, reaction cup discarded unit 100, liquid portion 110 and controller 120 shown in Fig. 1~3.
Reaction cup feeding mechanism 10 can offer several reaction cup 152 that the user arbitrarily puts into successively and transport rotating disk 20.Reaction cup feeding mechanism 10 is as shown in Figure 2, comprising: be assemblied in feeding warehouse 12 on the instrument host, be positioned at two guide plates 13 of feeding warehouse 12 belows, the feed that disposes at a certain distance at the positioning table 14 of two guide plate 13 lower ends with apart from positioning table 14 with grasping hand (Catcher) 15 through carriage 11 (with reference to Fig. 1).Two guide plates 13 are with less than reaction cup 152 edge diameter, greater than the configuration that is parallel to each other of the interval of reaction cup 152 cup diameters.Pack into reaction cup 152 edges in the feeding warehouse 12 hang on two guide plates 13 landing to positioning table 14.Positioning table 14 can forward the reaction cup 152 of getting off from guide plate 13 landings to feed with grasping the position that hand 15 can grab.The reaction cup 152 that feed is used for that with extracting hand 15 positioning table 14 is turned over offers transports rotating disk 20.
The purpose that rotating disk 20 is transported in configuration be rotation transport reaction cup 152 that reaction cup feeding mechanism 10 provides be equipped with will the reagent that sample adds to reaction cup 152 in reagent container (do not have and illustrate).It is as shown in Figure 2 that this transports rotating disk 20, is made up of the annular secondary packaging platform 23 in circular reagent platform 21, the annular reagent platform 22 in circular reagent platform 21 outsides, annular reagent platform 22 outsides and panel sub-assembling platform 24 of annular of being disposed at annular secondary packaging platform 23 outsides.These panel sub-assembling platform 24, secondary packaging platform 23, circular reagent platform 21 and annular reagent platform 22 all can be respectively clockwise and be rotated counterclockwise, and each can rotate separately independently of each other.
Circular reagent platform 21 and annular reagent platform 22 are as shown in Figure 2, and several holes 21a and hole 22a are arranged respectively, and these holes 21a and hole 22a are at certain intervals along circumferential arrangement.Several reagent containers of all ingredients that the hole 21a of circular reagent platform 21 and annular reagent platform 22 and hole 22a add when being used to place dress from the sample preparations sample to be tested (not having diagram).One time panel sub-assembling platform 24 has at certain intervals along several columnar glass stand 24a and glass stand 23a of circumferential arrangement with secondary packaging platform 23, and glass stand 24a and glass stand 23a are used for fixing the reaction cup 152 that reaction cup feeding mechanism 10 provides.Be fixed in the reaction cup 152 among the panel sub-assembling platform 24 glass stand 24a and be used for the sample that the test tube 150 of device 3 is sent in packing processing time-division shipment.The sample of the reaction cup 152 when being fixed in reaction cup 152 among the secondary packaging platform 23 glass stand 23a and being used for secondary packaging and handling on panel sub-assembling platform 24 of packing.There is a pair of aperture relative position, glass stand 24a side, states the light of beam split optical fiber 58 ejaculations of lighting unit 50 after this is used to see through to aperture.
Sample packing arm 30 can be inhaled to move and be transported device 3 and transport to the sample in the test tube 150 of inhaling pan position 2a, and the sample branch that suction moves is filled to transports in the reaction cup 152 that rotating disk 20 transmits.
HIL detecting device 40 obtains optical information for presence of interference material (chyle, haemoglobin and cholerythrin) and concentration thereof in the preceding sample of mensuration interpolation reagent from sample.Particularly, 4 kinds of light (405n m, 575n m, 660n m and 800n m) of stating after the use in 5 kinds of light (340n m, 405n m, 575nm, 660n m and 800n m) that lighting unit 50 sends are measured presence of interference material and concentration thereof.Its medium wavelength 405n m's only can be by any light that absorbs of chyle, haemoglobin and cholerythrin.That is chyle, haemoglobin and bilirubinic influence have been reflected in the optical information that, records with the light beam of wavelength 405n m.In fact the light of wavelength 575n m can not be absorbed by cholerythrin, and can be absorbed by chyle and haemoglobin.Reflected the influence of chyle and haemoglobin in the optical information that promptly records with the light beam of wavelength 575n m.There is the light of 660n m and 800n m wavelength in fact can not be absorbed, and can only be absorbed by chyle by cholerythrin and haemoglobin.That is reflected the influence of chyle in the optical information that, gets with the flash ranging of wavelength 660n m and 800n m.Chyle can absorb the light from low wavelength domain 405n m to high wavelength domain 800n m wavelength, and the light of the light ratio wavelength 800n m of wavelength 660n m absorbs more easily.That is the optical information that, gets with the flash ranging of wavelength 800n m is littler than the influence of the optical information chyle that the flash ranging with wavelength 660n m gets.
The optical information that this HIL detecting device 40 obtains sample is carried out optical detecting (formal mensuration) at 80 pairs of samples of detecting unit and is carried out before.HIL detecting device 40 is as shown in Figure 2, obtains optical information from being fixed in the sample in the reaction cup 152 the panel sub-assembling platform 24 glass stand 24a.
In this embodiment, lighting unit 50 is as shown in Figure 2, the light source that uses when being used to provide HIL detecting device 40 and detecting unit 80 to carry out optical detecting.That is, a lighting unit 50 can supply HIL detecting device 40 and detecting unit 80 shared.Reagent packing arm 60 is shown in Fig. 1~2; The reagent branch that is used for transporting the reagent container (not having diagram) of rotating disk 20 deliveries installs in the reaction cup 152 of transporting on the rotating disk 20; Reagent is mixed with reaction cup 152 interior samples; Add reagent with this sample from optical detecting to HIL detecting device 40 that finish, the preparation sample to be tested.It is for establishing transporting between rotating disk 20 and the detecting unit 80 mobile response cup 152 that reaction cup is transferred device 70.Be equipped with the volumetric pipette of heating (not having diagram) near the front end of mentioned reagent packing arm 60, this volumetric pipette of heating is to have an ingredient that adds the heating apparatus of temperature function to reagent.
The mensuration that detecting unit 80 is used for preparing adding reagent at sample is heated with sample, and from this sample to be tested detection optical information.Detecting unit 80 is as shown in Figure 2, is made up of reaction cup carrying place 81 and the detecting device 82 that is disposed at reaction cup carrying place 81 belows.
Urgent injector 90 is established in order the emergency treatment sample to be carried out analyzing specimen handle shown in Fig. 1~2.The urgent emergency treatment sample that inserts when this urgent injector 90 can carry out analyzing and processing at the sample that conveyer 3 provides.The discarded unit 100 of reaction cup is used for discarded reaction cup 152 of transporting rotating disk 20.The discarded unit 100 of reaction cup is as shown in Figure 2, is used extracting hand 101, the discarded discarded hole 102 (with reference to Fig. 1) of establishing with extracting hand 101 separated certain intervals of distance and is placed the discarded case 103 of discarding 102 belows, hole to constitute by discarded.The discarded extracting hand 101 of using is used for the reaction cup 152 of transporting on the rotating disk 20 is passed through the discarded case 103 of discarded hole 102 (with reference to Fig. 1) shift-in.Nozzle when liquid portion 110 is used for sample analyzer 1 shutdown processing on each packing arm provides liquid such as clean-out system.
As shown in Figure 3, controller 120 can be with reaction cup feeding mechanism 10, transport rotating disk 20, sample packing arm 30, HIL detecting device 40, lighting unit 50, two reagent packing arms 60, reaction cup forwarder 70, detecting unit 80, urgent injector 90, the discarded unit 100 of reaction cup and liquid portions 110 carry out electronic signal transmission.Controller 120 is made up of CPU, ROM, RAM etc.; CPU is stored in the control program among the ROM in advance through carrying out; The action of above-mentioned each parts of control is stated analyzing specimen operation and maintenance operation (serving as to accomplish the operation that maintenance work is implemented) after letting pick-up unit 4 implement with this.
[analyzing specimen flow process]
Below carry out simple declaration with regard to carry out the process that analyzing specimen handles with above-mentioned analyser.Fig. 5 is the process flow diagram of the analyzing specimen operation steps of analyser shown in Figure 1.At first, the pick-up unit 2 of analyser 1 shown in Figure 1 and control device 4 difference energized carry out the initial setting up of sample analyzer 1.Make the device of mobile response cup 152 and each packing arm return initial position with this, the software of the controller 4a that is stored in control device 4 is carried out initialization.(step 1)
Transport the test tube rack 151 that is loaded with the test tube 150 of adorning sample (blood plasma) with conveyer 3 shown in Figure 2, so that test tube rack 151 is transported to the corresponding position (step 2) with detection system 2 suction pan position 2a from test tube rack configuring area 3a.In step 3, inhale from test tube 150 with sample packing arm 30 again and move a certain amount of sample.Sample packing arm 30 moved on to be fixed on reaction cup 152 tops of transporting on 20 panel sub-assembling platforms 24 of rotating disk.Then, the sample that spues in the reaction cup 152 of sample packing arm 30 on panel sub-assembling platform 24 is promptly accomplished the step that the sample branch installs to reaction cup 152.
Rotate one time panel sub-assembling platform 24, the reaction cup 152 of the sample of will packing into moves on to the position that HIL detecting device 40 can be measured.At step S4, carry out optical detecting through 40 pairs of samples of HIL detecting device, obtain optical information from sample.Then, at step S5, the controller 4a of control device 4 uses the digital signal data (first optical information) that receives to calculate the absorbance of sample, calculates presence of interference material in the sample (chyle, haemoglobin and cholerythrin) and concentration thereof simultaneously.
Then, at step S6, judge whether the absorbance be stored among the RAM401c has and be lower than threshold value.At step S6, if the absorbance that first optical information that records from HIL detecting device 40 is calculated exceeds threshold value, then explain and contain a large amount of interference materials in the sample, can't carry out correct analysis, so abort process.If the absorbance that first optical information that records from HIL detecting device 40 is calculated is lower than threshold value; Then inhale from the reaction cup 152 on the glass stand 24a that is fixed on a panel sub-assembling platform 24 by sample packing arm 30 and move a certain amount of sample at step S7; Respectively inject a certain amount of sample by sample packing arm 30 to several reaction cup 152 on secondary packaging platform 23 again, carry out secondary packaging.
At step S8, quantitative sample is cultivated certain hour.This section incubation time is different because of the mensuration project, is generally about 1~3 minute.At step S9, drive the reagent that adds the reagent container (not having diagram) that is placed on circular reagent platform 21 and the annular reagent platform 22 in the sample of reagent packing arm 60 in secondary packaging platform 23 reaction cup 152, modulate sample to be tested with this.Transfer the jack (not having diagram) that reaction cup 152 on the secondary packaging platform 23 that device 70 will be equipped with sample to be tested moves to reaction cup carrying place 81 of detecting unit 80 with reaction cup then.
At step S10, carry out optical detecting (formal mensuration) by the sample to be tested in 82 pairs of reaction cup of detecting device 152 of detecting unit 80, obtain optical information (second optical information) from sample to be tested.After the analysis that the control device 4 controller 4a of step S11 carry out finished, at step S12, the analysis result that above-mentioned steps S11 is obtained was presented on the display 4b of control device 4, and the analyzing and processing of analyser 1 is promptly accused completion like this.
[record of maintenance history and demonstration]
Make analyser 1 operate as normal of said structure, bring into play due performance, just must carry out various maintainings.This maintaining as previously mentioned; Having need be in the project that stops manually to be carried out by user and maintenance personal under the state of apparatus working; Such as " discarded sample hose " and " reagent removes and reveals " etc., the project that need let instrument move such as " cleaning volumetric pipette " etc. is arranged also.In this embodiment; When carrying out the latter's maintaining because of operational analysis appearance 1, the record of this maintenance carries out automatically, has saved the trouble that the user carries out maintenance record in addition; Alleviated user's burden; Simultaneously, because maintenance condition is self registering, can prevent to forget record and misregistration etc.In this embodiment, maintenance history is stored among the RAM401c (storer) of above-mentioned control device 4, and the indicated number of the CPU401a that this historical basis of storage plays a role as display control section is on display 4b.When the time comes, maintenance history is different according to its kind, is presented on the aforementioned display device 4b with the calendar form or the form on date of date complete list.So-called " calendar form " refers to such as the demonstration that is in line of date of one month, has or not maintenance with mark and written record below the date, is convenient to show the maintenance history of every day and short span weekly.On the other hand, so-called " date form " then be with the maintaining of implementing with the date (on July 26th, 2006 or put down on July 26th, 18) be recorded in this Maintenance Significant Items position such as the next door, be convenient to show every month or the maintenance history of annual long span.
In this embodiment, the instrument itself that the user carries out routine analysis operation stores maintenance history, and this maintenance history of storage is presented on the display such as screen, and therefore, the operation of instrument can relevantly be carried out with the maintenance of instrument.Thereby make maintaining obtain conscientiously easily implementing, ensured the confidence level of instrument, can analyze accurately.Above-mentioned maintenance history can show such as clicking " maintenance " icon on the menu that can when starting the control device 4 of analyser 1, show on the display 4b or clicking " maintenance " icon at toolbar.
Fig. 6 is an example of this display frame.In Fig. 6, A is explicit user Maintenance and Repair plan and historical maintenance plan history display district, and B shows the relevant guidance panel district that safeguards the action button of picture.So,, therefore can confirm maintenance history in the limit owing to show the operation screen and the historical picture that shows maintenance history of control attended operation simultaneously, limit indication attended operation, thus can only implement necessary maintenance really.
Maintenance plan history display district A is different according to safeguarding kind, divides four viewing areas.Be that maintenance plan history display district A is divided into " operating repairs project ", " all Maintenance and Repair projects " of carrying out weekly that every day, start was all carried out, " month Maintenance and Repair project " of carrying out in every month and " the Maintenance and Repair project accessory when needing is changed " of carrying out as required.
" operating repairs project " and " all Maintenance and Repair projects " is with aforementioned calendar form record maintenance history.As " operating repairs project " following project is arranged: " cleaning volumetric pipette ", promptly clean to inhale and move and the volumetric pipette of packing sample and reagent (cleaning of carrying out when measuring each sample is different, is to strengthen cleaning); " discarded sample hose " outwells to be placed on and uses reaction cup (sample hose) in the discarded case, empties discarded case; " liquid waste processing " handled with clean-out system etc.; " reagent removes and reveals " removes attached to being cooled to the dewfall on the reagent container about 10 ℃ for the storage life that prolongs reagent; And " affirmation of anti-backflow chamber ", Visual Confirmation prevents that liquid from accumulating liquid to indoor the having or not that compressor flows backwards, if accumulate, then outwells this liquid.As " all Maintenance and Repair projects " " cleaning stream " arranged, promptly clean the liquid flow paths such as pipe that connect above-mentioned volumetric pipette.
" operating repairs project " shows the performance mark in the zone (lattice) corresponding to each date, in this embodiment, to additional white circle (zero) mark of projects of every day.When implementing to become black circle (●) mark when safeguarding." all Maintenance and Repair projects " then in the past a date of execution play per seven days zone one " zero " arranged, when implementing to safeguard,, be that benchmark upgrades the position of " zero " with this date of execution in the corresponding space additional " ● " of date of execution.So, through showing maintenance plan, can implement necessary maintenance conscientiously.That is, the also storage system maintenance plan of above-mentioned storer, above-mentioned display control section also shows maintenance plan in aforementioned display device.With this, when the user carries out the routine analysis operation, be easy to confirm maintenance plan.Therefore, can prevent to miss maintenance opportunity, carry out attended operation in good time, thereby be maintained the reliability of instrument, analyze accurately.Above-mentioned display control section is in the demonstration of the above-mentioned maintenance history of above-mentioned calendar form; When having implemented attended operation on the corresponding date; First mark of then having implemented " ● " at this date corresponding region data representing attended operation; If do not implement attended operation, then at unenforced second mark of above-mentioned zone data representing attended operation " zero ".With this, the user can see whether having implemented attended operation like a cork.
Above-mentioned " operating repairs project " and " all Maintenance and Repair projects " shows with the calendar form owing to maintenance history; So can hold maintenance condition very clearly; Such as, can know the project of not safeguarding intuitively, thereby can implement effectively to safeguard.Promptly; Maintenance history not only shows date on display or week, also safeguards performance corresponding to each date or week demonstration, after implementing attended operation; The displaying contents of maintenance history is updated, and can confirm the date of execution of the upkeep operation that frequent (such as every day or weekly) implements quickly.As " month Maintenance and Repair project " " cleaning stream " arranged, this with carry out " cleaning stream " same basically maintenance weekly.The position and the scavenging period that but clean are different, clean more thorough than cleaning weekly.
" replacing of the accessory of Maintenance and Repair project in case of necessity " project has: " the replacing illuminating lamp " of changing the illuminating lamp that uses as light source in the determinator; Perverse " the replacing probe " of wearing the probe (piasa) of rubber bolt when replacing is moved sample from inhaling the container of rubber bolt sealing; Remove " the wiping probe " of the filth on the probe; " pressure regulation " of pneumatic supply (compressor) pressure move or to use during packing sample etc. inhaled in adjustment; Pump " drawing water " and " the adding water " of in the instrument stream, injecting of the water in the instrument stream during when not using instrument for a long time or change instrument place to place.In the projects of " replacing of the accessory of Maintenance and Repair project in case of necessity ", show three times the history of Maintenance and Repair in case of necessity in the past at most, show and implement predetermined day and working order next time.For can and starting the number of times parts of prediction replacing time, infer and safeguard predetermined day according to running time.This infers by the CPU401a that plays a role as predetermined day presumption units and carries out, such as, can calculate (prediction) according to the transport maximum number of times (time) of these parts and the present running number of times (time) and the elapsed time of the preceding full maintenance date of execution of distance.This embodiment is predetermined day of the enforcement of inferring and the display lighting lamp is changed and probe is changed.With this, can predict the replacing date of replacing as the illuminating lamp and the probe of consumables, buy in advance or these consumables of stock.Consequently can prevent owing to the parts deficiency stops instrumentation.
" month Maintenance and Repair project " is different with " all Maintenance and Repair projects " with " the operating repairs project " that show with the calendar form with " replacing of the accessory of Maintenance and Repair project in case of necessity ", shows with the date form.When carrying out when changing this unscheduled maintenance of consumables, because of the enforcement time interval of safeguarding (more changing jobs) longer, generally be unit or year be unit with the moon; To show its history with the form of calendar; Perhaps demonstration is very little, perhaps relates to several pictures, and is plain on the contrary.And show with the form on date, can obtain necessary information at an easy rate.As stated, in this embodiment, according to safeguarding that kind (regular or irregular, short-term span or long-term span) shows.
Guidance panel district B shows and safeguards relevant various action buttons, clicks action that each button can show the automatically maybe preparation or the auxiliary movement of this action.When so-called " preparation of operation or auxiliary movement " refers to such as " replacing volumetric pipette " volumetric pipette is moved to the replacing position here, completion is retracted original position This move (warming-up exercise) with this volumetric pipette after manually changing operation again; Carry out this illuminating lamp correct operation (auxiliary movement) after artificial replacing is accomplished when " replacing illuminating lamp ".Promptly mean to the user implements attended operation and do running work (action that occurs along with attended operation) at this said " preparation of operation or auxiliary movement ".In this embodiment, this preparation or auxiliary movement also are used as the relevant attended operation of this action and carry out maintenance record automatically.In this manual, so-called " attended operation " refers to not only resemble that analyser 1 carries out the operation of the overall process of upkeep operation automatically " cleaning stream ", also comprises above-mentioned " preparation of operation or auxiliary movement ".
In Fig. 6, C is the demonstration switching push button of guidance panel, clicks this switching push button and can show the guidance panel of one page down.The below that shows switching push button C shows " page or leaf/total page number now ".As shown in Figure 7 on the guidance panel of following one page, show that " pressure regulation ", " adding water " reach " drawing water " each action button.About the button of " cleaning ",, just show and confirm dialog box (not having diagram) in the illustrated operation button, confirm dialog box at this as long as click this button, click " implementations " button just by fixed order begin cleaning.When this " cleaning " finishes, at respective regions " ● " mark that end is implemented in expression appears automatically.As previously mentioned, in this embodiment, B has disposed the action button of implementing attended operation in the guidance panel district of operation interface, and the user can be through clicking these action button indication attended operations.But, also can take other structures as the device of accepting the attended operation indication that the user sends.Such as; As the device of accepting the attended operation indication; Also can take as with the icon of attended operation content imageization; In operation interface, show the figure (image) be different from button, select the operation of this figure, promptly click the mouse and the indication of the beginning attended operation that the user sends is accepted in keyboard operation through the user.Like this, the user if in the selection operation interface in the indicating graphic that shows with desirable Maintenance Significant Items graph of a correspondence, can assign the indication of this attended operation.
Below according to the automatic renewal of the process description maintenance history of Fig. 8 along with this attended operation.In the drawings, left-half has shown the control procedure of computer 401, and what right half part showed is the control procedure of determination unit controller.
At first, at step S21, whether computer (PC) 401 judges have imported log-on messages such as username and password, if imported the log-on message of defined, then carry out login authentication at step S22.Then, S23 judges whether success identity in step, like authentification failure, then finishes running, like authentication success, then shows interface of main menu at next step step S24.At this interface of main menu, the user assign the indication that shows the maintenance management interface (such as, click certain icon), then read the maintenance history plan (step S26) that is stored in the storer, maintenance history and plan are presented at maintenance management interface (step S27).At step S28, computer (PC) 401 judges whether to receive at guidance panel district B operating operation button and begins the indication of attended operation.If receive the indication of attended operation, then at step S29, computer 401 is to the order of determination unit controller transmission beginning attended operation.
At step S30, the determination unit controller judges whether to receive the order of above-mentioned beginning attended operation.If judge to receive orders, then the determination unit controller carries out attended operation at this instrument of step S31 control according to a definite sequence.
At step S32, the determination unit controller judges in the attended operation whether break down, if break down, then at step S33 failure message is sent to computer (PC) 401.On the other hand, if do not break down, then judge whether to accomplish the service action of regulation at step S34; If do not accomplish; Then return step S31 and continue the control attended operation,, then operate completion information to computer (PC) 401 delivery of maintenance at step S35 if accomplished attended operation.
On the other hand, computer (PC) 401 at step S36, judges whether to receive failure message from this determination unit controller after step S29 is transferred to the determination unit controller with the attended operation initiation command.If receive failure message, then show fault at step S37, if do not receive failure message, then judge whether to receive attended operation completion information at step S38.Do not accomplish information if receive attended operation, then return step S36, accomplish information if receive attended operation, then historical in step S39 updating maintenance.Particularly, with the user name of login accordingly with Maintenance Significant Items and date storage in the storer, " zero " of these lattice in the maintenance management interface is changed to " ● " mark that completion is safeguarded in expression.
In this embodiment illustration, at step S28, computer (PC) 401 judges whether to receive the indication that begins to safeguard (maintenance) operation at guidance panel district B operating operation button.But be not limited thereto,, also can manually import the performance of this operation when user's manual implementation during not by the maintenance work of operation aforesaid operations button.At this moment, computer 401 judgements have or not input attended operation performance, if imported, then carry out the later processing of above-mentioned steps S39 and get final product.
In this embodiment, can write down automatically from login name and safeguard the responsible official, with this can be clear and definite analyser responsibility system or the management system safeguarded.Responsible official's name is stored among the RAM401c of the control device 4 that plays a role as storer.In order to simplify displaying contents, preferably be not presented at display interface, just only when printing maintenance history, export.Like this; After analyser is implemented to safeguard; User profile and this maintenance record of login has correlativity ground and stores above-mentioned storer automatically into, saved the trouble that the user writes down maintenance separately, simultaneously with reference to this maintenance record can the particular implementation attended operation the user.Owing to comprise the implementer of operation in the maintenance record, can carry out more appropriate management to the information of relevant maintenance.
In maintenance; Have such as " discarded sample hose " and " reagent removes dew " etc. and stopping under the apparatus working state by user and the manual project of maintenance personal; Can artificial import because of the maintenance history viewing area, carry out centralized management on the display so can all maintenance history unifications that comprise this Maintenance Significant Items hand-manipulated be presented at.In this case, for implementing the Maintenance Significant Items of attended operation by instrument, can forbid artificial input maintenance record according to the indication of computer (PC) 401.Like this, can prevent artificial mistake input to the Maintenance Significant Items that instrument is implemented and be recorded as the project of implementing.
This structure can also be removed forbidding above-mentioned manual input when login name is scheduled in input.Such as, when instrument breaks down, can imagine that the user can't carry out common attended operation, instrument keeps in repair but the personnel that can need repairing this moment are turned round by force.In this case, when the maintenance personal imports certain login name running instrument, can remove the ban of manual input, can artificial import, so just can write down the maintenance that the maintenance personal carries out.
This time disclosed embodiment can be thought and is illustration in all respects, exhausted unrestriction.Scope of the present invention is not limit by the explanation of above-mentioned embodiment, only by shown in the scope of claims, and comprises with the claim scope having all distortion in the same meaning and the claim scope.

Claims (13)

1. sample analyzer of analyzing urine or blood comprises:
Storer, the maintenance history of storing this sample analyzer;
Display; And
Display control section, according to the maintenance history of said memory stores at the maintenance management interface that shows the maintenance history during being used to be illustrated in several on the display;
Distinguish during in the wherein above-mentioned maintenance management interface several being arranged, during each is described, show in the district with each during the maintenance history of corresponding, every day or short span weekly, and with calendar form demonstration maintenance history;
Wherein, during showing several district, also show being different from that the said form of expression ground of distinguishing during several showed every month or the zone of the maintenance history of annual long span in the said maintenance management interface, and
Said maintenance management interface shows the maintenance history of said short span and the maintenance history of said long span simultaneously.
2. according to the said sample analyzer of claim 1, the corresponding maintenance plan of demonstration is distinguished in the also storage system maintenance plan of wherein said storer during each.
3. according to claim 1 or 2 said sample analyzers; Wherein said display control section is controlled said display; When during this period having implemented upkeep operation at said first mark that district's relevant position data representing has been implemented to safeguard during each; When not implementing upkeep operation, data representing is not implemented second mark of upkeep operation.
4. according to claim 1 or 2 said sample analyzers, wherein said display control section said display said during several in district corresponding during in the zone, show the history of the Maintenance Significant Items of regularly implementing.
5. according to the said sample analyzer of claim 1, wherein said display control section shows the date of enforcement upkeep operation with literal for the Maintenance Significant Items of irregular enforcement at said display.
6. according to the said sample analyzer of claim 1; Also comprise the importation of accepting user's input; Wherein when the Maintenance Significant Items of date of implementing upkeep operation and enforcement has been imported in said importation; Said storer can store as said maintenance history being illustrated in the information that this date implemented said Maintenance Significant Items, this maintenance history that said display control unit branch shows according to the said display of the said information updating of said memory stores.
7. according to the said sample analyzer of claim 6, also comprise according to carry out authentication, and the decision entering device that whether allows the user to login in the user's information of said importation input;
Wherein, said storer is when said importation has been imported Maintenance Significant Items and implemented the date of upkeep operation, with the user profile of login and Maintenance Significant Items data and the date data corresponding stored of being imported thereof.
8. according to claim 1,2,6 or 7 any said sample analyzers, wherein, guide look showed date or in week, also shows and each date or week safeguard performance accordingly when said display control section showed said maintenance history on said display.
9. sample analyzer of analyzing urine or blood comprises:
Storer is stored this sample analyzer maintenance plan and maintenance history;
Display; And
Display control section, according to the maintenance history of said memory stores at the maintenance management interface that shows the maintenance history during being used to be illustrated in several on the display;
Wherein, distinguish during in the above-mentioned maintenance management interface several being arranged, during each is described, show in the district with each during the maintenance history of corresponding, every day or short span weekly, and with calendar form demonstration maintenance history;
Wherein, during showing several district, also show being different from that the said form of expression ground of distinguishing during several showed every month or the zone of the maintenance history of annual long span in the said maintenance management interface, and
Said maintenance management interface shows the maintenance history of said short span and the maintenance history of said long span simultaneously.
10. according to the said sample analyzer of claim 9, wherein, said display control unit spare said display said during several in district corresponding during the district show the Maintenance Significant Items plan of regularly implementing.
11. according to the said sample analyzer of claim 9, wherein, for the Maintenance Significant Items of irregular enforcement, said display control section shows the target date of implementing upkeep operation at said display with literal.
12., also comprise and infer predetermined day predetermined day estimating unit of said maintenance according to claim 9 or 10 said sample analyzers.
13. according to the said sample analyzer of claim 12, wherein, said storer also storage system maintenance is historical;
Estimating unit was inferred said maintenance predetermined day according to the maintenance history of said memory stores in said predetermined day.
CN 200710142060 2006-08-22 2007-08-22 Sample analyzer Active CN101131386B (en)

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