CN101129514A - Fat-benefiting health care composition capsule and its preparing method - Google Patents
Fat-benefiting health care composition capsule and its preparing method Download PDFInfo
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Abstract
The invention relates to a health composition capsule for tonifying kidney, nourishing vital spirit, enriching blood, resisting ageing, oxidation, lowering blood fat, as well as the process for preparation, wherein the composition comprises haw extract, radix polygoni multiflori extract, American ginseng extract and gynostemma pentaphylla extract by the weight ratio of 50-80 : 10-14 : 10-14 : 10-12.
Description
Technical field
The present invention relates to a kind of fat-benefiting health care composition capsule and preparation method thereof, the present invention includes Fructus Crataegi extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract, Herb Gynostemmae Pentaphylli extract, have the effect that spleen, vigorate qi and replenish the blood, promoting flow of QI and blood, defying age antioxidation, blood fat reducing are built in the kidney invigorating.
Technical background
Scientific research proves that the aging of human body is relevant with free radical with the disease more than 90%.Human cell tissue is aging with advancing age, adding external factor causes oxygen-derived free radicals to generate too much, make the disorderly and whole body multi-section position cell tissue damage of immunity of organism regulatory mechanism, the generation that causes human body diseases with increase the weight of, and accelerated the aging of body, in addition, with the quickening pace of modern life, dietary habit is also to hyperpyrexia, high fat development.Hyperlipidemia is the key factor that the cardiovascular and cerebrovascular vessel prevalence takes place, and blood circulation diseases such as coronary heart disease, hypertension, angina pectoris, hyperlipidemia and sickness rate and mortality rate present and continue the trend that rises.For this reason, Chinese patent 200610047106.2 discloses a kind of Halth-care composition of blood lipid regulation.It is by Ganoderma extract, Fructus Crataegi extract, and consumption such as perilla oil, phospholipid etc. are to scale made.Have serum cholesterol (TC), the triglyceride (TG) that can reduce the user significantly, and remarkable characteristics of high density lipoprotein increasing cholesterol (HDL), have the health-care effect of fine blood lipid regulation.But this patent does not have the kidney invigorating key spleen, vigorate qi and replenish the blood, antidotal effect, therefore, needs to propose a kind of fat-benefiting health care composition capsule and preparation method thereof.
Summary of the invention
The object of the present invention is to provide a kind of fat-benefiting health care composition capsule and preparation method thereof, the present invention is a raw material by Fructus Crataegi, Radix Polygoni Multiflori, Radix Panacis Quinquefolii, Herb Gynostemmae Pentaphylli, Fructus Crataegi extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract, Herb Gynostemmae Pentaphylli extract effective ingredient and positive role separately organically combined, produce the effect of the kidney invigorating key spleen, vigorate qi and replenish the blood, defying age, blood fat reducing, and can remove to remove free radical, alleviating physical fatigue strengthens body immunity.
An object of the present invention is to realize by following technical proposals: a kind of fat-benefiting health care composition capsule, comprise Fructus Crataegi extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract, Herb Gynostemmae Pentaphylli extract, the weight portion proportioning of described each extract is:
Fructus Crataegi extract 50-80 part
Radix Polygoni Multiflori extract 10-14 part
Radix Panacis Quinquefolii extract 10-14 part
Herb Gynostemmae Pentaphylli extract 10-12 part
The mode that described each extract can adopt alcohol extraction, water to carry obtains.
Another object of the present invention is realized by following technical proposals: a kind of preparation method of fat-benefiting health care composition capsule is a raw material by Fructus Crataegi, Radix Polygoni Multiflori, Radix Panacis Quinquefolii, Herb Gynostemmae Pentaphylli, and preparation process is as follows:
The preparation of I, Fructus Crataegi extract:
A, extraction are Fructus Crataegi slice with Fructus Crataegi, drop into after Fructus Crataegi slice are weighed in the dipping extraction pot;
B, inject ethanol in the extraction pot, under 40-60 ℃ of condition impregnation process 1-2 hour to dipping; Isolate single-steeping liquid then, inject ethanol to dipping in the extraction pot again, under 40-60 ℃ of condition impregnation process 1-2 hour; Isolate double-steeping liquid then; In this dipping leaching process, described alcohol concentration is 40-50%; The injection rate that described ethanol is each and the weight ratio of Fructus Crataegi slice are 4-6: 1;
C, twice impregnation liquid mixed, carry out concentrating under reduced pressure less than-0.05MPa, temperature under less than 70 ℃ of conditions in vacuum and handle, obtain concentrated solution;
D, described concentrated solution is carried out filtration treatment, obtain filtrate;
E, described filtrate is squeezed in the extraction tower, used n-butyl alcohol to extract processing, obtain butanol extraction liquid;
F, butanol extraction liquid is carried out concentrating under reduced pressure less than-0.05MPa, temperature under less than 70 ℃ of conditions in vacuum handle, obtain the extraction concentrated solution;
G, described extraction concentrated solution is carried out spray drying treatment obtain Powdered Fructus Crataegi extract;
The preparation of II, Radix Polygoni Multiflori extract:
A, extraction are medicinal sections with Radix Polygoni Multiflori, drop into after Radix Polygoni Multiflori is weighed in the dipping extraction pot;
B, inject ethanol in the extraction pot, under 70-85 ℃ of condition impregnation process 1-2 hour, isolate single-steeping liquid then to dipping; Inject hot water to dipping in the extraction pot again, under 70-85 ℃ of condition impregnation process 2-3 hour; Isolate double-steeping liquid then; In the soaking in alcohol leaching process, described alcohol concentration is 40-50%; The injection rate of described ethanol and the weight ratio of Radix Polygoni Multiflori are 4-6: 1, and in the Hot water immersion leaching process, the weight ratio of water and Radix Polygoni Multiflori is 4-5: 1;
C, with the impregnation liquid mix homogeneously that gradation obtains, regulating pH value is 8.0, leaves standstill 12 hours, isolates supernatant then;
D, place vacuum to handle less than carrying out concentrating under reduced pressure under 70 ℃ of conditions supernatant, obtain concentrated solution less than-0.05MPa, temperature;
E, described concentrated solution is carried out spray drying treatment obtain Powdered Radix Polygoni Multiflori extract;
The preparation of III, Radix Panacis Quinquefolii extract
A, extraction are medicinal sections with Radix Panacis Quinquefolii, drop into after Radix Panacis Quinquefolii is weighed in the dipping extraction pot;
B, inject ethanol in the extraction pot, under 70-85 ℃ of condition impregnation process 1-2 hour, isolate single-steeping liquid then to dipping; Inject hot water to dipping in the extraction pot again, under 70-85 ℃ of condition impregnation process 2-3 hour; Isolate double-steeping liquid then; In the soaking in alcohol leaching process, described alcohol concentration is 40-50%; The injection rate of described ethanol and the weight ratio of Radix Panacis Quinquefolii are 4-6: 1, and in the Hot water immersion leaching process, the weight ratio of water and Radix Panacis Quinquefolii is 4-5: 1;
C, with the impregnation liquid mix homogeneously that gradation obtains, regulating pH value is 8.0, leaves standstill 12 hours, isolates supernatant then;
D, place vacuum to handle less than carrying out concentrating under reduced pressure under 70 ℃ of conditions supernatant, obtain concentrated solution less than-0.05MPa, temperature;
E, described concentrated solution is squeezed in the extraction tower, used n-butyl alcohol to extract processing, obtain butanol extraction liquid;
F, butanol extraction liquid is carried out concentrating under reduced pressure less than-0.05MPa, temperature under less than 70 ℃ of conditions in vacuum handle, obtain the extraction concentrated solution;
G, described extraction concentrated solution is carried out spray drying treatment obtain Powdered Radix Panacis Quinquefolii extract;
IV, Herb Gynostemmae Pentaphylli extract preparation
A, extraction are medicinal sections with Herb Gynostemmae Pentaphylli, drop into after Herb Gynostemmae Pentaphylli is weighed in the dipping extraction pot;
B, inject ethanol in the extraction pot, under 70-85 ℃ of condition impregnation process 1-2 hour, isolate single-steeping liquid then to dipping; Inject hot water to dipping in the extraction pot again, under 70-85 ℃ of condition impregnation process 2-3 hour; Isolate double-steeping liquid then; In the described soaking in alcohol leaching process, described alcohol concentration is 40-50%; The injection rate of described ethanol and the weight ratio of Herb Gynostemmae Pentaphylli are 4-6: 1, and in the described Hot water immersion leaching process, the weight ratio of water and Herb Gynostemmae Pentaphylli is 4-5: 1;
C, with the impregnation liquid mix homogeneously that gradation obtains, regulating pH value is 8.0, leaves standstill 12 hours, isolates supernatant then;
D, place vacuum to handle less than carrying out concentrating under reduced pressure under 70 ℃ of conditions supernatant, obtain concentrated solution less than-0.05MPa, temperature;
E, described concentrated solution is squeezed in the extraction tower, used n-butyl alcohol to extract processing, obtain butanol extraction liquid;
F, butanol extraction liquid is carried out concentrating under reduced pressure less than-0.05MPa, temperature under less than 70 ℃ of conditions in vacuum handle, obtain the extraction concentrated solution;
G, described extraction concentrated solution is carried out spray drying treatment obtain Powdered Herb Gynostemmae Pentaphylli extract;
V, with described Fructus Crataegi extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract, Herb Gynostemmae Pentaphylli extract according to 50-80 part: 10-14 part: 10-14 part: the weight portion proportioning of 10-12 part is mixed, branch is encapsulated behind the mix homogeneously, every capsules packing 0.2-0.3 gram.
Compared with the prior art the present invention has following advantage:
1, the present invention combines Fructus Crataegi extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract, Herb Gynostemmae Pentaphylli extract effective ingredient and positive role separately, has produced the effect of the kidney invigorating key spleen, vigorate qi and replenish the blood, defying age, blood fat reducing.
2, the present invention can remove to remove free radical, alleviating physical fatigue, and blood lipid regulation strengthens body immunity.
3, extraction process of the present invention can be protected the effective ingredient in the extract to greatest extent.
The specific embodiment
Embodiment one:
A kind of fat-benefiting health care composition capsule comprises Fructus Crataegi extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract, Herb Gynostemmae Pentaphylli extract, and the weight portion proportioning of described each extract is:
Fructus Crataegi extract 50-80 part
Radix Polygoni Multiflori extract 10-14 part
Radix Panacis Quinquefolii extract 10-14 part
Herb Gynostemmae Pentaphylli extract 10-12 part
The mode that described each extract can adopt alcohol extraction, water to carry obtains.
Extract in the present embodiment can also extract according to embodiment four disclosed preparation methoies, and described extract weight proportioning unit can adopt gram, ten grams, hectogram, kilogram, the proportioning of each extract can be in the scope of said ratio flexible combination.The compositions of present embodiment adopts capsule preparations, perhaps adopts the enteric-soluble controlled-release capsule preparation, and every capsules packing 0.2-0.3 gram is taken the 4-6 grain every day.In addition, also can adopt other conventional dosage form mode.
In the present invention, Fructus Crataegi sour in the mouth, sweet, slightly warm in nature is gone into spleen, stomach, Liver Channel; Contain flavones ingredient, lipase composition, vitamin C, vitamin B in the Fructus Crataegi extract
1, vitamin B
2Deng.Contained lipase material can increase in the stomach enzyme secretion, and facilitating digestion also can promote fat food digestion, the blood fat reducing blood vessel dilating is arranged and improve the effect of myocardial metabolism; Contained flavones ingredient has important function such as blood pressure lowering, coronary blood flow increasing, blood fat reducing, microcirculation improvement; Fructus Crataegi extract also has the effect of the free radical of removing.Radix Polygoni Multiflori bitter in the mouth, sweet, puckery, slightly warm in nature is gone into liver, kidney channel; Energy the liver and the kidney tonifying, enrich and benefit essence and blood, loosening bowel to relieve constipation, defying age.Radix Panacis Quinquefolii sweet in the mouth, little hardship, cool in nature, go into the heart, lung, kidney channel; Energy lung benefiting the moon, clear asthenic fire, promoting the production of body fluid to quench thirst; Contain 17 kinds of ginsenosides in the Radix Panacis Quinquefolii extract, the ginsenoside has facilitation to the lipid metabolism of normal animal, and blood middle-high density lipoprotein cholesterol is raise, and has to prevent the atherosclerosis effect preferably.The Herb Gynostemmae Pentaphylli bitter in the mouth, cold in nature, go into lung meridian; Energy eliminating inflammation and expelling toxin, eliminating phlegm and stopping cough, strengthening by means of tonics; Herb Gynostemmae Pentaphylli extract can be expanded the heart, cerebrovascular, improves blood circulation, reduces endovascular cholesterol, makes neutral fat acid be easy to excrete, thereby reaches the effect of triglyceride reducing (TG), low density lipoprotein, LDL (LDL); It can alleviate peroxidating by blood fat reducing content on the other hand, effectively improve SOD (superoxide dismutase) level in the cell, eliminate free radical, reduce the content of lipofuscin and lipid peroxide (LPO), and then improve the ability of body anti-peroxidation damage.In the present invention, based on Fructus Crataegi extract (monarch drug), long-pending strengthening the spleen and stomach helps digestion, taste are strong, and then QI and blood biochemistry is active, Radix Panacis Quinquefolii extract is auxilliary (ministerial drug), supplementing QI and nourishing YIN, Radix Polygoni Multiflori extract (adjuvant drug), the liver and the kidney tonifying, kidney qi is filled, liver blood is prosperous, QI and blood foot then, congenital be so incensed that to constantly the replenishing of gas of the day after tomorrow and kidney essense is abundant, send, kidney essense can be guaranteed the normal performance of spleen and stomach function plentifully again; Herb Gynostemmae Pentaphylli extract (messenger drug), the effect of performance strengthening by means of tonics makes QI and blood foot and blood vessels are smooth, and four kinds of extract reasonable compatibilities are played the effect of the kidney invigorating key spleen, vigorate qi and replenish the blood, defying age, blood fat reducing altogether.
Embodiment two:
Present embodiment is the preferred version on embodiment one basis, and its extracting mode, unit of weight also can be identical with embodiment one, and the weight portion proportioning of described each extract is:
Fructus Crataegi extract 60-70 part
Radix Polygoni Multiflori extract 11-13 part
Radix Panacis Quinquefolii extract 11-13 part
Herb Gynostemmae Pentaphylli extract 10-11 part.
Embodiment three:
Present embodiment is the preferred version on embodiment one basis, and its extracting mode, unit of weight also can be identical with embodiment one, and the weight portion proportioning of described each extract is:
65 parts of Fructus Crataegi extracts
12 parts of Radix Polygoni Multiflori extracts
12 parts of Radix Panacis Quinquefolii extracts
11 parts of Herb Gynostemmae Pentaphylli extracts.
Embodiment four:
A kind of preparation method of fat-benefiting health care composition capsule is a raw material by Fructus Crataegi, Radix Polygoni Multiflori, Radix Panacis Quinquefolii, Herb Gynostemmae Pentaphylli, and preparation process is as follows:
The preparation of I, Fructus Crataegi extract:
A, extraction are Fructus Crataegi slice with Fructus Crataegi, and these Fructus Crataegi slice are dried Fructus Crataegi slice, or medicinal Fructus Crataegi slice, drop into after Fructus Crataegi slice are weighed in the dipping extraction pot.
B, inject ethanol in the extraction pot to dipping, under 40-60 ℃ of condition impregnation process 1-2 hour, isolate single-steeping liquid then, in the dipping extraction pot, inject ethanol again, under 40-60 ℃ of condition impregnation process 1-2 hour; Isolate double-steeping liquid then; In this dipping leaching process, described alcohol concentration is 40-50%; The injection rate that described ethanol is each and the weight ratio of Fructus Crataegi slice are 4-6: 1; In the present embodiment, preferred impregnation process temperature is 50 ℃, and the preferred impregnation process time is 1.5 hours, in order to guarantee uniformity, should stir material once in per 10 minutes, stirs one minute at every turn; Preferred alcohol concentration is 50%; The preferred weight ratio of ethanol and Fructus Crataegi slice is 5: 1.
C, twice impregnation liquid mixed, vacuum≤-carry out concentrating under reduced pressure under the 0.05MPa, temperature≤70 ℃ condition to handle, obtain concentrated solution; Concentrating the equipment that uses is conventional concentrating under reduced pressure pot, and the volume of concentrated solution is that twice ethanol injects 2/5ths of total amount.
D, described concentrated solution is carried out filtration treatment, obtain filtrate; Before the filtration treatment, concentrated solution should be cooled to below 30 ℃; The filtrate outward appearance is auburn limpid bright liquid.
E, described filtrate is squeezed in the extraction tower, used n-butyl alcohol to extract processing, obtain butanol extraction liquid; Extraction is handled and can be carried out three times; For the first time, the volume ratio of filtrate and n-butyl alcohol is 1: 3; For the second time, the volume ratio of filtrate and n-butyl alcohol is 1: 2; For the third time, the volume ratio of filtrate and n-butyl alcohol is 1: 1; Extraction tower belongs to conventional equipment.
F, with butanol extraction liquid vacuum≤-carry out concentrating under reduced pressure under the 0.05MPa, temperature≤70 ℃ condition to handle, obtain the extraction concentrated solution; Concentrating the equipment that uses is conventional concentrating under reduced pressure pot, and the volume of concentrated solution is that three n-butyl alcohol inject 1/5th of total amount.
G, described extraction concentrated solution is carried out spray drying treatment obtain Powdered Fructus Crataegi extract; Spray drying is used conventional equipment.In the present embodiment, the Fructus Crataegi slice raw material uses 9000 grams, can obtain Fructus Crataegi extract 650 grams.
The preparation of II, Radix Polygoni Multiflori extract:
A, extraction are medicinal sections or dry sheet with Radix Polygoni Multiflori, drop into after Radix Polygoni Multiflori is weighed in the dipping extraction pot;
B, inject ethanol in the extraction pot, under 70-85 ℃ of condition impregnation process 1-2 hour, isolate single-steeping liquid then to dipping; Inject hot water to dipping in the extraction pot again, under 70-85 ℃ of condition impregnation process 2-3 hour; Isolate double-steeping liquid then; In the soaking in alcohol leaching process, described alcohol concentration is 40-50%; The injection rate of described ethanol and the weight ratio of Radix Polygoni Multiflori are 4-6: 1, and in the Hot water immersion leaching process, the weight ratio of water and Radix Polygoni Multiflori is 4-5: 1; Can also to carry out impregnation process for the third time in order economizing in raw materials, to inject hot water to dipping in the extraction pot again, under 70-85 ℃ of condition impregnation process 2-3 hour; Isolate impregnation liquid then three times.In the soaking in alcohol leaching process, preferred dipping temperature is 85 ℃, and the preferred impregnation process time is 1.5 hours, in order to guarantee uniformity, should stir material once in per 10 minutes, stirs one minute at every turn; Preferred alcohol concentration is 40%; The preferred weight ratio of ethanol and Radix Polygoni Multiflori is 6: 1.In the Hot water immersion leaching process, preferred dipping temperature is 80 ℃, and the preferred impregnation process time is 3 hours, should stir material once in per 10 minutes, stirs one minute at every turn; The weight ratio of hot water and Radix Polygoni Multiflori is 4.5: 1.
C, with the impregnation liquid mix homogeneously that gradation obtains, regulating pH value is 8.0, leaves standstill 12 hours, isolates supernatant then;
D, with supernatant place vacuum≤-carry out concentrating under reduced pressure under the 0.05MPa, temperature≤70 ℃ condition to handle, obtain concentrated solution.
E, described concentrated solution is carried out spray drying treatment obtain Powdered Radix Polygoni Multiflori extract; In the present embodiment, the Radix Polygoni Multiflori raw material uses 1000 grams, can obtain Radix Polygoni Multiflori extract 120 grams.
The preparation of III, Radix Panacis Quinquefolii extract
A, extraction are medicinal sections with Radix Panacis Quinquefolii, drop into after Radix Panacis Quinquefolii is weighed in the dipping extraction pot;
B, inject ethanol in the extraction pot, under 70-85 ℃ of condition impregnation process 1-2 hour, isolate single-steeping liquid then to dipping; Inject hot water to dipping in the extraction pot again, under 70-85 ℃ of condition impregnation process 2-3 hour; Isolate double-steeping liquid then; In the soaking in alcohol leaching process, described alcohol concentration is 40-50%; The injection rate of described ethanol and the weight ratio of Radix Panacis Quinquefolii are 4-6: 1, and in the Hot water immersion leaching process, the weight ratio of water and Radix Panacis Quinquefolii is 4-5: 1; Can also carry out impregnation process for the third time, inject hot water to dipping in the extraction pot again, under 70-85 ℃ of condition impregnation process 2-3 hour; Isolate impregnation liquid then three times.In the soaking in alcohol leaching process, preferred dipping temperature is 85 ℃, and the preferred impregnation process time is 1.5 hours, stirs material once, stirs one minute at every turn in per 10 minutes; Preferred alcohol concentration is 40%; The preferred weight ratio of the injection rate of ethanol and Radix Panacis Quinquefolii is 6: 1.In the Hot water immersion leaching process, preferred dipping temperature is 80 ℃, and the preferred impregnation process time is 3 hours, and the weight ratio of hot water and Radix Panacis Quinquefolii is 4.5: 1.
C, with the impregnation liquid mix homogeneously that gradation obtains, regulating pH value is 8.0, leaves standstill 12 hours, isolates supernatant then;
D, with supernatant place vacuum≤-carry out concentrating under reduced pressure under the 0.05MPa, temperature≤70 ℃ condition to handle, obtain concentrated solution;
E, described concentrated solution is squeezed in the extraction tower, used n-butyl alcohol to extract processing, obtain butanol extraction liquid; Extraction is handled and can be carried out three times; For the first time, the volume ratio of concentrated solution and n-butyl alcohol is 1: 3; For the second time, the volume ratio of concentrated solution and n-butyl alcohol is 1: 2; For the third time, the volume ratio of concentrated solution and n-butyl alcohol is 1: 1.
F, with butanol extraction liquid vacuum≤-carry out concentrating under reduced pressure under the 0.05MPa, temperature≤70 ℃ condition to handle, obtain the extraction concentrated solution;
G, described extraction concentrated solution is carried out spray drying treatment obtain Powdered Radix Panacis Quinquefolii extract; In the present embodiment, the Radix Panacis Quinquefolii raw material uses 1000 grams, can obtain Radix Panacis Quinquefolii extract 120 grams.
IV, Herb Gynostemmae Pentaphylli extract preparation
A, extraction are medicinal sections with Herb Gynostemmae Pentaphylli, drop into after Herb Gynostemmae Pentaphylli is weighed in the dipping extraction pot;
B, inject ethanol in the extraction pot, under 70-85 ℃ of condition impregnation process 1-2 hour, isolate single-steeping liquid then to dipping; Inject hot water to dipping in the extraction pot again, under 70-85 ℃ of condition impregnation process 2-3 hour; Isolate double-steeping liquid then; In the described soaking in alcohol leaching process, described alcohol concentration is 40-50%; The injection rate of described ethanol and the weight ratio of Herb Gynostemmae Pentaphylli are 4-6: 1, and in the described Hot water immersion leaching process, the weight ratio of water and Herb Gynostemmae Pentaphylli is 4-5: 1; Can also carry out impregnation process for the third time, inject hot water to dipping in the extraction pot again, under 70-85 ℃ of condition impregnation process 2-3 hour; Isolate impregnation liquid then three times.In the soaking in alcohol leaching process, preferred dipping temperature is 85 ℃, and the preferred impregnation process time is 1.5 hours, stirs material once, stirs one minute at every turn in per 10 minutes; Preferred alcohol concentration is 40%; The preferred weight ratio of ethanol and Herb Gynostemmae Pentaphylli is 6: 1.In the Hot water immersion leaching process, preferred dipping temperature is 80 ℃, and the preferred impregnation process time is 3 hours, and the weight ratio of hot water and Herb Gynostemmae Pentaphylli is 4.5: 1.
C, with the impregnation liquid mix homogeneously that gradation obtains, regulating pH value is 8.0, leaves standstill 12 hours, isolates supernatant then;
D, with supernatant place vacuum≤-carry out concentrating under reduced pressure under the 0.05MPa, temperature≤70 ℃ condition to handle, obtain concentrated solution;
E, described concentrated solution is squeezed in the extraction tower, used n-butyl alcohol to extract processing, obtain butanol extraction liquid; Extraction is handled and can be carried out three times; For the first time, the volume ratio of concentrated solution and n-butyl alcohol is 1: 3; For the second time, the volume ratio of concentrated solution and n-butyl alcohol is 1: 2; For the third time, the volume ratio of concentrated solution and n-butyl alcohol is 1: 1.
F, with butanol extraction liquid vacuum≤-carry out concentrating under reduced pressure under the 0.05MPa, temperature≤70 ℃ condition to handle, obtain the extraction concentrated solution;
G, described extraction concentrated solution is carried out spray drying treatment obtain Powdered Herb Gynostemmae Pentaphylli extract; In the present embodiment, the Herb Gynostemmae Pentaphylli raw material uses 1000 grams, can obtain Herb Gynostemmae Pentaphylli extract 110 grams.
V, with described Fructus Crataegi extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract, Herb Gynostemmae Pentaphylli extract according to 50-80 part: 10-14 part: 10-14 part: the weight portion proportioning of 10-12 part is mixed, branch is encapsulated behind the mix homogeneously, every capsules packing 0.2-0.3 gram.
Can also mix according to embodiment two or embodiment three disclosed weight portion proportionings, divide encapsulated, every capsules packing 0.2-0.3 gram.
Composition capsule of the present invention detects through Disease Prevention Control Center, Hubei Prov, assert that the present invention has the blood lipid regulation effect.Test sample title: hundred million dimension board benefit fat capsules, No. the 2002017th, (2002) searching.
Testing result:
Hundred million dimension board benefit fat capsule blood lipid regulation adopt the disorderly modelling of prevention type lipid metabolism in rats, recommend 10,20,30 times of human intaking amount (0.6g/60kg.bw) to be equivalent to manufacturer, as basic, normal, high dosage group (corresponding actual dose be 0.1,0.2,0.3g/kg.bw).Adopt SPF level Wistar rat oral to irritate stomach, the result shows: 1) compare with model control group, basic, normal, high dosage group rat body weight when the 5th week is starkly lower than model control group, and difference has significance (P<0.05), but does not have significance with normal control group comparing difference.2) compare with model group, each dosage group total cholesterol level descended obviously at experimental session when experiment finished, and credit is analysed by statistics, and difference has significance (P<0.05, P<0.05, P<0.05).The average fall of basic, normal, high dosage group total cholesterol level is respectively 45.8%, 34.3%, 19.6%.Low dose group triglyceride content descends obviously, and credit is analysed by statistics, and difference has significance (P<0.05).The average fall of basic, normal, high dosage group triglyceride content is respectively 32.4%, 28.6%, 7.0%.Each dosage group does not all have the rising effect to HDL-C, and according to health food function assessment assessment process regulation, this is tried thing the blood lipid regulation effect.
Hyperlipemia is one of key factor of incidence of atherosclerosis.The blood fat reducing level for the control cardiovascular and cerebrovascular disease, reduces case fatality rate and has crucial meaning.Through human feeding trial proof the present invention of fat-benefiting health care composition being had the effect of blood lipid regulation, its test is as follows:
1 clinical data
Whole cases all meet experimenter's mass selection and select standard.The patient adopts the table of random number method to be divided into 2 groups, selects patient 100 people of age in the non-simple hyperlipidemia voluntary participation test of being in hospital that meets experimenter group's regulation in 40-50 year.Keep on ordinary days life and dietary habit during being tried, get the every index of hematometry on an empty stomach, blood sampling is 2 times in half a year, and twice serum total cholesterol (TC) is 5.5-6.24mmol/L or serum triglycerides (TG) 1.7-2.2mmol/L can be used as the experimenter.Matched group 50 examples.
2 test methods
Test group is taken fat-benefiting health care composition capsule.Specification 150mg/ grain, each 4, every day 3 times.Looked into 1 time blood fat in per 1 month, 3 months is 1 course of treatment.Matched group is not done any processing.The duration of test experimenter does not change original life and dietary habit, normal diet.
3 indexs detect: adopt automatic clinical chemistry analyzer that the blood fat that 2 groups of patients test front and back is detected.Statistical method: adopt SPSS 8.0 for Windows statistical softwares, measurement data adopts paired t-test before and after two groups of tests; Relatively adopt the independent sample t check between group.
4 safety indexes observed results:
Heart rate, blood pressure, electrocardiogram, the fluoroscopy of chest of X line, Abdominal B type ultrasonography, routine urinalysis, stool routine examination, routine blood test and biochemical indicator testing result see Table 1 before and after the test.Every index is all in normal range before and after the test of test-meal group and matched group, and no significant difference before and after the test-meal.Show that this sample does not have tangible influence to routine blood test and biochemical indicator.
Blood testing index before and after table 1 test (x ± s)
Project | Matched group (N=50) | Test-meal group (N=50) | ||
Before the test-meal | After the test-meal | Before the test-meal | After the test-meal | |
Erythrocyte 10-12/L | 4.45±0.33 | 4.39±0.35 | 4.46±0.30 | 4.47±0.32 |
Hemoglobin (g/L) | 132.60±13.43 | 133.4±12.7 | 132.47±13.5 | 131.67±13.3 |
Total white blood cells (10-9/L) | 6.82±2.10 | 6.70±1.9 | 6.51±1.56 | 6.46±1.27 |
Platelet (10-9/L) | 141±37.23 | 143.12±36.70 | 144.01±50.12 | 146.78±54.3 |
Glutamate pyruvate transaminase (U/L) | 18.56±7.50 | 17.98±7.67 | 19.45±8.03 | 20.03±8.34 |
Glutamic oxaloacetic transaminase, GOT (U/L) | 22.13±6.13 | 22.45±5.78 | 22.35±6.23 | 23.02±6.12 |
Total bilirubin (umol/L) | 15.03±4.56 | 14.89±4.67 | 15.20±5.07 | 15.31±4.76 |
Total protein (g/L) | 72.67±3.46 | 73.04±3.57 | 74.35±3.54 | 75.27±3.47 |
Albumin (g/L) | 46.08±2.14 | 46.12±2.20 | 46.13±2.12 | 46.25±2.30 |
Blood urea nitrogen mol/L) | 5.52±1.18 | 5.79±1.58 | 5.76±1.32 | 5.97±1.38 |
Creatinine (umol/L) | 97.11±12.30 | 100.01±12.81 | 102.56±13.06 | 103.14±12.45 |
Routine urinalysis | Normally | Normally | Normally | Normally |
Just conventional | Normally | Normally | Normally | Normally |
5 effect index determining results
See Table 2 before and after the test-meal between serum total cholesterol TC, blood triglyceride TG, HDL-C HDL-C content, table 3, table 4
The variation of serum TC before and after table 2 test-meal (mmol/l, x ± s)
Group | The example number | Before the test-meal | After the test-meal | Average rate of decrease (%) |
The test-meal group | 50 | 6.1±0.11 | 5.3±0.12 | 12.5 |
Matched group | 50 | 5.6±0.10 | 5.5±0.13 | 1.2 |
The variation of serum TG before and after table 3 test-meal (mmol/l, x ± s)
Group | The example number | Before the test-meal | After the test-meal | Average rate of decrease (%) |
The treatment group | 50 | 2.01±0.02 | 5.3±0.03 | 7.5 |
Matched group | 50 | 1.82±0.03 | 1.81±0.05 | 0.6 |
The variation of Serum HDL-C before and after table 4 test-meal (mmol/l, x ± s)
Group | The example number | Before the test-meal | After the test-meal | Average climbing (%) |
The treatment group | 50 | 1.45±0.03 | 1.466±0.02 | 1.1 |
Matched group | 50 | 1.41±0.04 | 1.4275±0.03 | 1.2 |
Blood Lipid relatively before and after two groups of experimenters tested, take blood triglyceride before and after the fat-benefiting health care composition capsule group test, T-CHOL, all significantly reductions (P<0.05) before the test, wherein, take fat-benefiting health care composition capsule group test back T-CHOL and blood triglyceride, content and be starkly lower than matched group (P<0.05), matched group then changes not obvious.Take not have obviously before fat-benefiting health care composition capsule group test back HDL-C content is tested and raise.According to health food function assessment assessment process regulation, illustrate that fat-benefiting health care composition has the effect of blood lipid regulation.
Claims (4)
1. fat-benefiting health care composition capsule, it is characterized in that: comprise Fructus Crataegi extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract, Herb Gynostemmae Pentaphylli extract, the weight portion proportioning of described each extract is:
Fructus Crataegi extract 50-80 part
Radix Polygoni Multiflori extract 10-14 part
Radix Panacis Quinquefolii extract 10-14 part
Herb Gynostemmae Pentaphylli extract 10-12 part
The mode that described each extract can adopt alcohol extraction, water to carry obtains.
2. fat-benefiting health care composition capsule according to claim 1 is characterized in that: the weight portion proportioning of described each extract is:
Fructus Crataegi extract 60-70 part
Radix Polygoni Multiflori extract 11-13 part
Radix Panacis Quinquefolii extract 11-13 part
Herb Gynostemmae Pentaphylli extract 10-11 part.
3. fat-benefiting health care composition capsule according to claim 1 is characterized in that: the weight portion proportioning of described each extract is:
65 parts of Fructus Crataegi extracts
12 parts of Radix Polygoni Multiflori extracts
12 parts of Radix Panacis Quinquefolii extracts
11 parts of Herb Gynostemmae Pentaphylli extracts
4. the preparation method of a fat-benefiting health care composition capsule, it is characterized in that: by Fructus Crataegi, Radix Polygoni Multiflori, Radix Panacis Quinquefolii, Herb Gynostemmae Pentaphylli is raw material, and preparation process is as follows:
The preparation of I, Fructus Crataegi extract:
A, extraction are Fructus Crataegi slice with Fructus Crataegi, drop into after Fructus Crataegi slice are weighed in the dipping extraction pot;
B, inject ethanol in the extraction pot, under 40-60 ℃ of condition impregnation process 1-2 hour to dipping; Isolate single-steeping liquid then, inject ethanol to dipping in the extraction pot again, under 40-60 ℃ of condition impregnation process 1-2 hour; Isolate double-steeping liquid then; In this dipping leaching process, described alcohol concentration is 40-50%; The injection rate that described ethanol is each and the weight ratio of Fructus Crataegi slice are 4-6: 1;
C, twice impregnation liquid mixed, carry out concentrating under reduced pressure less than-0.05MPa, temperature under less than 70 ℃ of conditions in vacuum and handle, obtain concentrated solution;
D, described concentrated solution is carried out filtration treatment, obtain filtrate;
E, described filtrate is squeezed in the extraction tower, used n-butyl alcohol to extract processing, obtain butanol extraction liquid;
F, butanol extraction liquid is carried out concentrating under reduced pressure less than-0.05MPa, temperature under less than 70 ℃ of conditions in vacuum handle, obtain the extraction concentrated solution;
G, described extraction concentrated solution is carried out spray drying treatment obtain Powdered Fructus Crataegi extract;
The preparation of II, Radix Polygoni Multiflori extract:
A, extraction are medicinal sections with Radix Polygoni Multiflori, drop into after Radix Polygoni Multiflori is weighed in the dipping extraction pot;
B, inject ethanol in the extraction pot, under 70-85 ℃ of condition impregnation process 1-2 hour, isolate single-steeping liquid then to dipping; Inject hot water to dipping in the extraction pot again, under 70-85 ℃ of condition impregnation process 2-3 hour; Isolate double-steeping liquid then; In the soaking in alcohol leaching process, described alcohol concentration is 40-50%; The injection rate of described ethanol and the weight ratio of Radix Polygoni Multiflori are 4-6: 1, and in the Hot water immersion leaching process, the weight ratio of water and Radix Polygoni Multiflori is 4-5: 1;
C, with the impregnation liquid mix homogeneously that gradation obtains, regulating pH value is 8.0, leaves standstill 12 hours, isolates supernatant then;
D, place vacuum to handle less than carrying out concentrating under reduced pressure under 70 ℃ of conditions supernatant, obtain concentrated solution less than-0.05MPa, temperature;
E, described concentrated solution is carried out spray drying treatment obtain Powdered Radix Polygoni Multiflori extract;
The preparation of III, Radix Panacis Quinquefolii extract
A, extraction are medicinal sections with Radix Panacis Quinquefolii, drop into after Radix Panacis Quinquefolii is weighed in the dipping extraction pot;
B, inject ethanol in the extraction pot, under 70-85 ℃ of condition impregnation process 1-2 hour, isolate single-steeping liquid then to dipping; Inject hot water to dipping in the extraction pot again, under 70-85 ℃ of condition impregnation process 2-3 hour; Isolate double-steeping liquid then; In the soaking in alcohol leaching process, described alcohol concentration is 40-50%; The injection rate of described ethanol and the weight ratio of Radix Panacis Quinquefolii are 4-6: 1, and in the Hot water immersion leaching process, the weight ratio of water and Radix Panacis Quinquefolii is 4-5: 1;
C, with the impregnation liquid mix homogeneously that gradation obtains, regulating pH value is 8.0, leaves standstill 12 hours, isolates supernatant then;
D, place vacuum to handle less than carrying out concentrating under reduced pressure under 70 ℃ of conditions supernatant, obtain concentrated solution less than-0.05MPa, temperature;
E, described concentrated solution is squeezed in the extraction tower, used n-butyl alcohol to extract processing, obtain butanol extraction liquid;
F, butanol extraction liquid is carried out concentrating under reduced pressure less than-0.05MPa, temperature under less than 70 ℃ of conditions in vacuum handle, obtain the extraction concentrated solution;
G, described extraction concentrated solution is carried out spray drying treatment obtain Powdered Radix Panacis Quinquefolii extract;
IV, Herb Gynostemmae Pentaphylli extract preparation
A, extraction are medicinal sections with Herb Gynostemmae Pentaphylli, drop into after Herb Gynostemmae Pentaphylli is weighed in the dipping extraction pot;
B, inject ethanol in the extraction pot, under 70-85 ℃ of condition impregnation process 1-2 hour, isolate single-steeping liquid then to dipping; Inject hot water to dipping in the extraction pot again, under 70-85 ℃ of condition impregnation process 2-3 hour; Isolate double-steeping liquid then; In the described soaking in alcohol leaching process, described alcohol concentration is 40-50%; The injection rate of described ethanol and the weight ratio of Herb Gynostemmae Pentaphylli are 4-6: 1, and in the described Hot water immersion leaching process, the weight ratio of water and Herb Gynostemmae Pentaphylli is 4-5: 1;
C, with the impregnation liquid mix homogeneously that gradation obtains, regulating pH value is 8.0, leaves standstill 12 hours, isolates supernatant then;
D, place vacuum to handle less than carrying out concentrating under reduced pressure under 70 ℃ of conditions supernatant, obtain concentrated solution less than-0.05MPa, temperature;
E, described concentrated solution is squeezed in the extraction tower, used n-butyl alcohol to extract processing, obtain butanol extraction liquid;
F, butanol extraction liquid is carried out concentrating under reduced pressure less than-0.05MPa, temperature under less than 70 ℃ of conditions in vacuum handle, obtain the extraction concentrated solution;
G, described extraction concentrated solution is carried out spray drying treatment obtain Powdered Herb Gynostemmae Pentaphylli extract;
V, with described Fructus Crataegi extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract, Herb Gynostemmae Pentaphylli extract according to 50-80 part: 10-14 part: 10-14 part: the weight portion proportioning of 10-12 part is mixed, branch is encapsulated behind the mix homogeneously, every capsules packing 0.2-0.3 gram.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102861180A (en) * | 2012-09-27 | 2013-01-09 | 福州海王福药制药有限公司 | Amino-acid-containing composition capable of improving conditions of patients with cardiovascular and cerebrovascular diseases and application of amino-acid-containing composition |
CN102972594A (en) * | 2012-11-30 | 2013-03-20 | 浙江农林大学 | Antihypertensive tea capable of effectively preventing atherosclerosis, and preparation method thereof |
CN103416651A (en) * | 2013-07-11 | 2013-12-04 | 威海金颐阳药业有限公司 | American ginseng gynostemma pentaphylla electuary |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102861180A (en) * | 2012-09-27 | 2013-01-09 | 福州海王福药制药有限公司 | Amino-acid-containing composition capable of improving conditions of patients with cardiovascular and cerebrovascular diseases and application of amino-acid-containing composition |
CN102972594A (en) * | 2012-11-30 | 2013-03-20 | 浙江农林大学 | Antihypertensive tea capable of effectively preventing atherosclerosis, and preparation method thereof |
CN103416651A (en) * | 2013-07-11 | 2013-12-04 | 威海金颐阳药业有限公司 | American ginseng gynostemma pentaphylla electuary |
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