CN101123944A - Oral care composition containing extract of unoxidized camellia - Google Patents

Abstract

An oral composition for at least one or treating and inhibiting an oral inflammatory condition comprising: a Camellia extract including at least about 30% epigallocatechin gallate, at least about 50% total catechins, and at least about 60% total polyphenols; and a substantially water insoluble non-cationic anti-bacterial agent.

Description

The oral care composition that contains extract of unoxidized camellia

The cross reference of related application

It is 60/639,079 and 60/639,080 that the application has required serial number, all is filed in the priority of 23 days U.S. Provisional Patent Application of December in 2004, and its content all is incorporated herein as a reference.

Background of invention

[0001] oral inflammation as gingivitis and periodontitis, is common oral condition.Gingivitis is the inflammation of gums, and it is the primary stage of gum disease.The immediate cause that causes gingivitis is a dental plaque, and it is the colorless film of softish, the viscosity that contains antibacterial that forms on tooth and gums.If dental plaque without treatment, will generation can make the toxin of gingival tissues inflammation or infection and cause gingivitis.Gingivitis will finally be diffused into the ligament and the bone of supports tooth without treatment from gums, thereby causes periodontitis.Though have the different treatment methods of multiple prevention and inhibition oral inflammation, these methods all also need to improve.

[0002] antioxidant is those chemical compounds that help to suppress the oxidation reaction that caused by active oxygen or oxygen-derived free radicals.Active oxygen produces in health naturally as the product of chemical reaction in the conventional cellular process.Active oxygen also can be owing to excess contamination, too much UV sunlight and be exposed in the smoke from cigarette and produce.Active oxygen species for stable can combining with intravital other molecules of body oxidation they, it causes, the destruction of cell membrane for example, the oxidation of the infringement of DNA and lipid (fat).Oxidation finally can cause cancer, heart disease, apoplexy, rheumatic arthritis, cataract and Alzheimer.

[0003] antioxidant can be with many different mode inhibited oxidation reactions.The oxygen-derived free radicals material that antioxidant can cleaning reaction and/or reduce partial oxygen concentration and reduce the oxidation potential of molecular oxygen for example.There is multiple antioxidant to exist and antioxidant can be from multiple different source.Typical antioxidant comprises vitamin E, vitamin C, and carotenoid, and polyphenol are as flavonoid.

Summary of the invention

[0004] in a specific embodiments of the present invention, provides at least a composition for oral cavity that is used for oral cavity inflammation treatment and inhibition.This composition for oral cavity comprises: contains at least about 30% epigallocatechin gallate (EGCG), and the total catechin at least about 50%, and at least about Flos Camelliae Japonicae (Camellia) extract of 60% total polyphenols; With basic water insoluble non-cationic anti-bacterial.

[0005] in another specific embodiments of the present invention, the treatment and at least a method of inhibition that are used for oral inflammation are provided.This method comprises that the oral cavity to the patient that these needs are arranged applies the composition for oral cavity of effective dose, said composition comprises and containing at least about 30% epigallocatechin gallate (EGCG), total catechin at least about 50%, and at least about the Camellia extract of 60% total polyphenols.

[0006] in another specific embodiments of the present invention, provides the treatment and the inhibition that are used for oral inflammation at least a, and the method for antioxidant activity is provided in the oral cavity.This method comprises has the oral cavity of the animal subject of these needs to apply the composition for oral cavity and the halogenated diphenyl ether antibacterial of effective dose to people or other, said composition comprises and containing at least about 3 0% epigallocatechin gallate (EGCG), total catechin at least about 50%, and at least about the Camellia extract of 60% total polyphenols.

[0007] in a plurality of embodiments, the compositions and methods of the invention further comprise antibacterial, as triclosan.In a plurality of embodiments, said composition and method further comprise Herba Rosmarini Officinalis extract.

[0008] we find that compositions and method among the present invention are better than those antiinflammatories known in the art and antioxidative compositions and method.These advantages comprise with the composition for oral cavity that contains the natural green tea extract provides the anti-inflammatory activity of reinforcement and the antioxidant activity of reinforcement.Further application of the present invention, beneficial effect and specific embodiments can be found out from the description of this paper.

Detailed Description Of The Invention

[0009] composition for oral cavity according to the present invention comprises the extract that obtains from the member's of Camellia tissue.Compositions of the present invention can show anti-inflammatory and/or antioxidative effect when it is introduced into the oral cavity.This anti-inflammatory and/or antioxidant activity also can strengthen during as triclosan and/or Herba Rosmarini Officinalis extract also comprise other antibacterial in composition for oral cavity of the present invention.

[0010] in a plurality of embodiments, the present invention can be provided for treating and/or suppress oral inflammation and introduce the composition for oral cavity of antioxidant activity to the oral cavity.This composition for oral cavity can adopt any dosage form that is applicable to oral administration.Its illustrative examples comprises: dentifrice, and as toothpaste, gutta-percha, tooth frost, or dentifrice; Collutory, gargarism, mouth spraying agent; The oral cavity is with serosity or liquid teeth cleaning agent; Chewing gum or other confections; Cough drop; Dental floss or dental tape; Prevention grinding paster (prophylaxis paste) or powder; The oral film of single or multiple lift or gel strips, for example tooth bar or breathe bar preferably adopts the film or the gel of biodegradable or orally consumable; Functional membrane or gel film or functional millimeter, micron or nano level granule; The film-forming composition that comprises pregel (one or more) or prepolymer (one or more) as film forming dentifrice, is coated with the tooth agent; Tooth hardener; Or the oral cavity coating, use utensil or implant as orthodontics.

[0011] the invention provides the composition for oral cavity that comprises Camellia extract.This Camellia extract is from obtaining the unoxidized Camellia plant tissue basically.Although the extract of unoxidized Camellia sinensis is preferred, any kind, the Camellia of form or subspecies can use.Preferably subspecies or mutation are: C.sinensisvar.assamica, C.assamica and var.kucha; C.sinensisvar.cambodiensis, subsp.lasiocalyx and var.Shan; C.sinensisvar.dehungensis; C.sinensis var. pubilimba; And C.sinensisvar.sinensis, bohea, macrophylla, parvifolia, and waldenae.

[0012] in a preferred embodiment, this Camellia extract can be from C.sinensis var.assamica, obtains in the unoxidized substantially tissue (one or more) of C.sinensis var.cambodiensis or C.sinensis var.sinensis; In a preferred embodiment, this extract can be made by the unoxidized substantially tissue (one or more) of C.sinensis var.assamica or C.sinensis var.sinensis; In a preferred embodiment, this extract can be by obtaining in the unoxidized substantially tissue (one or more) of C.sinensisvar.sinensis.No matter what the source is, leaf tissue can be preferred, although any leaf bud, flower, alabastrum; Multiple stem, multiple twig; A kind of stem, a kind of twig, and trunk bark; Root; Root bark; With other gas first portions and regenerating section with and combination can adopt.

[0013] Camellia extract can be a form arbitrarily, comprises powder, suspension, emulsion and/or oil.

[0014] Camellia tissue (one or more) that is used for producing any extract that uses in the present invention can be passed through any known method preparation in this area.For example, if use blade, blade should remain in its color and pluck in green, and heating rapidly after plucking, and before about 30 minutes after adopting, more generally is before about 10 minutes.Heating can be implemented by any mechanism: with pot heating, steam, baking, microwave, as long as make temperature rapidly (in about 5-15 minute or shorter time) rise to the temperature of the basic degeneration of catabolic enzymes that can make in the tissue.After this heating steps, can blade is air-dry, or otherwise dehydration.

[0015] in the above described manner or the plant tissue processed of any other mode can use any suitable known extractive technique to extract and make useful in the present invention extract.For example operable extractive technique comprises any suitable aqueous extraction or organic solvent extraction.Preferred extractive technique adopts water, methanol, water/methanol, dichloromethane and methanol: THF.Can use any other suitable extractive technique, as steam distillation and supercritical fluid extraction.

[0016] Camellia extract can be present in the composition for oral cavity with multiple content.Preferably, Camellia extract is with greater than about 0.001%, and preferred about 0.001% to about 20%; Preferred about 0.01% to about 15%; Preferred about 0.05% to about 10%; Preferred about 0.05% to 5%; Preferred about 0.05% to about 1%; Exist with preferred about 0.1% to about 0.2% amount.

[0017] the present invention can also comprise vitamin (tocopherol) and/or its derivant, or its analog.For example, tocopherol of the present invention comprises that those have the material of vitamin E biological activity and physiologically active, comprise α-, β-, γ-, δ-, ε-, ζ-and the natural d-form and the synthetic dl-form of η-tocopherol; The tocol that replaces, one on 5,7 and 8 of tocol benzodihydropyran nuclear wherein, two or three methyl groups are by one or more groups, as alkyl, alkylhalide group, hydroxyalkyl, aminoalkyl, acyl group and allyl group replace, and wherein at the methyl group of 2 of the benzodihydropyran of tocol nuclears by low-grade alkyl group, as ethyl, propyl group and butyl replace; With tocopherol anologs matter such as positive tocopherol (nor-tocopherol), wherein the quantity at the isoprene unit of 2 of benzodihydropyran nuclears is two, same tocopherol, the quantity of isoprene unit wherein is four, with different tocopherol, wherein the side chain of being made up of three isoprene units in the tocol is linear.

[0018] though, composition for oral cavity of the present invention can comprise any suitable natural or synthetic vitamin E tocopherol, vitamin E (dl-alpha tocopherol) (C ₂₉H ₅₀O ₂, be preferred mw430.72).Vitamin E can be from multiple different source, as the Royal DSM N.V. of Holland.Vitamin E can be present in the composition for oral cavity with multiple different level.For example, vitamin E can exist with the amount that anti-oxidation efficacy can be provided.For example, vitamin E can be with about 10 to about 10, and the amount of 000ppm exists, with about 15 to about 40ppm, and with about 20 to 30ppm, or the existence of the amount of about 25ppm.And vitamin E also can be with greater than about 0.001%, and with about 0.001% to about 5%, with about 0.01% to about 5%, with about 0.2% to about 4%, and about 0.3% to about 3% amount is present in the composition for oral cavity.

[0019] composition for oral cavity of the present invention can comprise the therapeutic agent of one or more interpolations, as antibacterial or antiinflammatory.Typical antibacterial can comprise halogenated diphenyl ether, benzoate, halogenated diphenyl urea, oxine and salt thereof; Zinc and stannous ion source, as zinc citrate, zinc sulfate, zinc glycinate, Zinc sodium citrate. and ditin diphosphate; The chloride of copper (II) chemical compound such as copper (II), fluoride, sulfate and hydroxide; Phthalic acid and salt thereof such as phthalic acid list potassium magnesium; Sanguinarine; Quaternary ammonium compound is as alkyl pyridinium chloride  (as hexadecylpyridinium chloride  (CPC), the combination of CPC and zinc and/or enzyme, myristyl pyridinium chloride  and N-myristyl-4-ethyl pyridinium chloride ); Biguanide, as the chlohexidine digluconate, hexetidine, octenidine, and Win-21904; The halogenated bisphenol chemical compound, as 2,2 '-di-2-ethylhexylphosphine oxide-(4-chloro-6-bromophenol); Benzalkonium chloride; N-phenylsalicylamide; The halo N-phenylsalicylamide; Domiphen bromide; Iodine; Sulfanilamide; Two biguanide (bisbiguanides); Phenolic compounds such as phenol and homologue thereof, single and many alkyl and aralkyl halophenol, and bisphenol compound; Sub-base derivatives of piperidine such as delmopinol and octapinol; Extract of magnolia; Semen Vitis viniferae extract; Thymol; Eugenol; Menthol; Geraniol; Carvacrol; Citral; Cineole; Catechol; 4-acrylic catechol; Resorcinol and derivant thereof are as hexyl resorcin; Methyl salicylate; Antibiotic such as Augmentin, amoxicillin, tetracycline, doxycycline, minocycline, metronidazole, neomycin, kanamycin and clindamycin; And their mixture.Further enumerating explanation and can be this reagent: 5,776,435 referring to U.S. Patent number; 5,681,548; 5,912,271 and 5,723,500 document, its content all is incorporated herein as a reference.

[0020] composition for oral cavity can, preferably also comprise one or more solubilizing agents and make Camellia extract dissolving.Solubilizing agent can be the effectively solubilizing agent of solubilize Camellia extract arbitrarily.For example, in a plurality of embodiments, solubilizing agent can be the oral cavity acceptable surfactant, flavored oils, at least a in the pure and mild solubilising wetting agent (as propylene glycol).

[0021] example of operable surfactant comprise anionic, non-ionic, amphoteric, zwitterionic, and cationic synthectic detergents.Anion surfactant comprises the soluble-salt (as alkyl sodium sulfate) of the alkyl sulfate that has 8-20 carbon atom in the alkyl, mono phosphoric acid ester alkyl salt with 6-18 carbon atom, the water soluble salt (as sodium lauryl sulfate (purity＞82%) and cocos nucifera oil monoglyceride sulfonates) of sulfonated monoglyceride with fatty acid of 8-20 carbon atom is single [alkyl (C ₁₂-C ₂₂₎]-[be 1-20 (Glyc)] alkyl polyglucoside; sarcosinate (as sodium N-lauroyl sarcosinate salt or potassium salt, myristoyl Sodium sarcosinate or potassium salt, palmitoyl sarcosine sodium salt or potassium salt, stearyl sarcosine sodium salt or potassium salt and oleoylsarcosine sodium salt or potassium salt); taurate; senior alkyl sulfoethanoic acid. salt (as lauryl sulfoethanoic acid. sodium); different thiosulfate (as the different sodium thiosulfate of lauroyl); laureth carboxylic acid sodium, dodecylbenzene sodium sulfonate and aforesaid mixture.Sarcosinate preferably is because their can be because breakdown of carbohydrates suppress formation sour in the oral cavity.Ionic surfactant pack is drawn together, poloxamer; Polyoxyethylene sorbitan ester; Alcohol ethoxylate; The polyethylene oxide condensation compound of alkyl phenol; Derive from oxirane and fatty acid, aliphatic alcohol, fatty acid amide, or the product of polyol condensating; The poly(propylene oxide) of aliphatic alcohol or ethylene oxide condensate; The long chain tertiary amine oxide; The long chain tertiary phosphine oxide; The long-chain dialkyl sulphoxide; And the mixture of above-mentioned substance.Amphoteric surfactant comprises betanin (as cocamidopropyl betaine), the derivant of secondary aliphatic amine and tertiary amine, aliphatic group wherein can be a straight or branched, and wherein one of aliphatic substituent group contains 8-18 the carbon atom of having an appointment, one contain the anionic water-soluble group (as carboxylate radical, sulfonate radical, sulfate radical, phosphate radical or phosphonate group), and the mixture of above-mentioned substance.Zwitterionic surfactant comprises aliphatic quaternary ammonium,  and sulfonium compound derivant, aliphatic group wherein can be a straight or branched, and wherein one of aliphatic substituent group contains 8-18 the carbon atom of having an appointment, one contains the anionic water-soluble group (as carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate group).Cationic surfactant comprises aliphatic quaternary ammonium compounds, it has a long alkyl chain that contains 8-18 the carbon atom of having an appointment (as lauryl trimethyl ammonium chloride, hexadecylpyridinium chloride , cetyl trimethyl ammonium bromide, diisobutyl phenoxy group ethyl dimethyl benzene ammonio methacrylate (diisobuytylphenoxyethyldimethylbenzylammonium chloride), cocos nucifera oil alkyl trimethyl ammonium nilrite (coconut alkyltrimethy lammoniumnitrite), cetyl is fluoridized pyridine ).Some cationic surfactant also can be used as antibacterial.

[0022] solubilizing agent (one or more) preferably exists with the amount of composition weight about 0.02% to about 50%.

[0023] this composition for oral cavity can also randomly comprise hardening agent (EA), and it is anionic polymer water soluble or expandable or copolymer, and it comprises strengthens group of sending and the group of strengthening retentivity.Strengthen the group of sending and strengthened Camellia extract sending to tooth and oral cavity tissue.The group of strengthening retentivity has strengthened the maintenance to Camellia extract of tooth and oral cavity tissue.Hardening agent among the present invention can comprise that those are can be used as the material that denture adhesive or fixative or dental cements are characteristics.This hardening agent is polymer or copolymer, and this term is general fully, therefore for example comprises oligomer, homopolymer, two or more monomeric copolymers, ionomer, block copolymer, graft copolymer, cross linked polymer and copolymer etc.EA can be natural or synthetic, and water (saliva) solvable or expandable (hydratable, as to form hydrogel) polymer or copolymer.EA can select multiple size, as (weight) mean molecule quantity (MW) is: about 100 to about 1,000,000; About 1,000 to about 1,000,000; Or about 2,000 to about 2,500, or about 250,000 to about 500,000.The group that the reinforcement of EA is sent can also be that U.S. Patent number is 5,538,715 and 5,776, any one in listing in 435, and the content of above-mentioned every piece of document all is incorporated herein as a reference.

[0024] strengthen the group send and be meant and adhere to or in large quantities, adhesively, bonding ground or otherwise be combined on the EA, and the Camellia extract composition is transported to the group on surface, oral cavity (as tooth and gingiva), thus, " sending " this composition is to this surface.The group of organic reinforcement retentivity is normally hydrophobic, and it makes Camellia extract adhere to or otherwise be combined on the EA, promotes that thus Camellia extract directly remains on the EA, and remains on oral surfaces indirectly.In some cases, adhering to of Camellia extract can be held back generation by EA to its physics alternatively or additionally, and especially when EA is cross linked polymer, its structure is inherently this and holds back more site is provided.The molecular weight that exists is high more, and cross linked polymer hydrophobicity crosslink part is just more, also just further promotes in crosslinked EA polymer or on crosslinked EA polymer the physics of Camellia extract to be held back.

[0025] this composition for oral cavity comprises the acceptable vehicle in oral cavity.The acceptable vehicle in any suitable oral cavity can adopt, and is 4,894,220 as those at U.S. Patent number, and name is called described in " the antibiotic composition for oral cavity that removes dental plaque ", and it is introduced into this paper as the reference file.For example this vehicle can comprise water and wetting agent.In the present invention, water and humectant liquid phase can account for the weight of composition for oral cavity at least about 10%.And preferred wetting agent comprises propylene glycol, and it can help solubilize Camellia extract.Other wetting agent is glycerol and/or sorbitol and/or xylitol preferably.Usually, the amount of water is at least about 3% by weight; And glycerol and/or sorbitol and/or xylitol account for about 6.5% to about 75% of oral preparations weight usually altogether, more generally be about 10% to about 75%, and add the solubilising wetting agent, the amount of necessary wetting agent composition normally oral preparations weight about 7% to about 80%.Sorbitol described here is meant commercially available about 70% water soluble materials usually.If compositions contains basic water insoluble non-cationic anti-bacterial, said composition will preferably not contain the Polyethylene Glycol of significant quantity at least, especially mean molecule quantity is about 600 or above, this is because Polyethylene Glycol can suppress the antibacterial activity of non-cationic antimicrobial agent, even exist other components this moment, influence its dissolubility as propylene glycol.

[0026] this vehicle can also be water-alcohol mixture.Usually, the weight ratio of water and alcohol about 1: 1 to about 20: 1 scope, preferred about 3: 1 to about 10: 1 and more preferably from about 4: 1 to about 6: 1.The total amount of water-alcohol mixture in mouthwash for example is usually in about scope of 70 to 99.9% by weight.Alcohol is nontoxic alcohol, as ethanol or isopropyl alcohol.Wetting agent, as glycerol, sorbitol, or the amount of xylitol can be by weight about 10 to about 30%.Composition for oral cavity can contain about by weight 5% to about 30% water.Liquid teeth cleaning agent contains 50% to about 85% the water of having an appointment usually, and about by weight 0.5% to about 20% non-toxic alcohol can be contained, and about by weight 10% to about 40% wetting agent can be contained, as glycerol, sorbitol, and/or xylitol.Sorbitol is meant commercially available about 70% water soluble materials usually.Ethanol is preferred non-toxic alcohol.Alcohol promotes the dissolving of Camellia extract and the insoluble non-cationic antimicrobial agent of water.

[0027] comprising one or more in dentifrice composition can prevent, treat and/or the therapeutic agent of the symptom that minimizing and various oral cavities or general disease or situation are relevant is desirable.Available therapeutic agent comprises the therapeutic agent that all are known in the art or develop, and it comprises steroid, NSAIDs, fluoride ion source, polycarboxylate polymer, polyvinyl methyl ether/maleic anhydride (PVME/MA) copolymer, arginine ester, zinc ion source, stannous ion source, delmopinol, tartar controlling agent, antibacterial, triclosan and salt thereof, chlohexidine, Win-21904, hexetidine, Sanguinarine, benzalkonium chloride, salicylanilide, domiphen bromide, hexadecylpyridinium chloride  (CPC), myristyl pyridinium chloride  (TPC), N-myristyl-4-ethyl group pyridinium chloride  (TDEPC), octenidine, octapinol, nisin, zinc ion source, copper ion source, essential oil, furanone (furanone), antiinflammatory, antiplaque agent, antioxidant, with bacteriocin and salt thereof, honokiol, vitamin, Antiadhesive, protein agent, peptide.United States Patent (USP) 5,776 provides the further specifying property tabulation to available antibacterial in 435, and its content is introduced into this paper as the reference file.

[0028] can in the dentifrice prescription, add grinding agent if desired.Any suitable oral care abrasive or polishing agent can use.Silica abrasive preferably, as precipitated silica, Polymeric sodium metaphosphate., potassium metaphosphate, tricalcium phosphate, Tri-Compress, aluminium silicate, calcined alumina, bentonite or other silicon raw material, microgranule thermosetting resin, as tripolycyanamide, phenol, and ureaformaldehyde and crosslinked polyepoxide and polyester.

[0029] any other additive can optionally be comprised in the dentifrice composition, owing to for example make, stability, aesthstic, curative effect, reasons such as the needs of consumer, typical additive comprises the dentifrice additive of every other routine, viscosity modifier, diluent, foam modifier, saliva stimulant, desensitizer, brightening agent, enzyme, the pH regulator agent, taste agent, sweeting agent, pigment, opacifier, and breath freshener.

[0030] the present invention also provides the composition for oral cavity that adopts among the present invention to treat and has suppressed the oral cavity symptom, as oral inflammation, is deposited on the dental plaque on tooth and the oral cavity tissue and the method and the technology of dental calculus.In addition, this composition for oral cavity also can be used as antioxidant.The present invention provides commercial packing to distribute for composition for oral cavity and has stored composition for oral cavity.

[0031] composition for oral cavity can act on the patient with any suitable way known in the art.For example, this composition for oral cavity can be with suitable applicator or delivery apparatus, as brush, and the tooth band, film, syringe, band, glue, pill or any other applicator known in the art or delivery apparatus are applied to patient's oral cavity.Said composition can should be used for promoting in prophylactic methods and technology and the maintenance oral health, outward appearance, and breath freshening.Composition for oral cavity can act on the patient repeatedly according to particular treatment and treat over many day and/or suppress dental plaque, dental calculus deposits, and oral inflammation, and antioxidant activity is provided.The description that therapeutic scheme is described can together provide with commercial packing.

[0032] the present invention is further described by following non-limiting example.

Embodiment 1

[0033] powder and/or oil extract obtain from Camellia sinensis.This extract is can be from as Sabinsa, and the Corp. place is purchased, and it can be Sabinsa gauge MS-0726-01.Camellia extract can comprise the epigallocatechin gallate (EGCG) at least about 30%, the total catechin at least about 50% and at least about 60% total polyphenols.Extract is introduced into human embryos jaw mesenchyme (messenchyme) the cells in vitro cell culture checking system that stimulates with 1L1 β.When extract is introduced check, the generation of PGE2 (PGE2) is obviously suppressed.PGE2 has notified and has caused inflammation.Therefore, the generation that suppresses PGE2 with extract reduces and inflammation-inhibiting easily.

Embodiment 2

[0034] preparation contains the solution of antiinflammatory triclosan and Camellia extract.Camellia extract exists as the desired concentration of antiinflammatory separately to be lower than Camellia extract.This solution is compared with independent triclosan solution and is shown higher anti-inflammatory activity.Therefore, Camellia extract can be worked in coordination with the antiphlogistic effects that strengthens triclosan with triclosan easily.

Embodiment 3

[0035] Camellia extract is included in the oral care product with various concentration, and is about 10% as being with about 0.01% in dentifrice, or any concentration between about 0.01% and about 10%, exists with one or more suitable surfactants.Oral care product can also comprise the triclosan and/or the Herba Rosmarini Officinalis extract of multiple concentration.

Embodiment 4

[0036] Camellia extract is included in the oral care product with various concentration, as in portable oral care strip with 0.1%, 0.2%, or any concentration between 0.1% and 0.2% exists with one or more suitable surfactants.Oral care strip is introduced a vitro system that contains the lipid peroxide of carrying out oxidation.This oral care strip has reduced lipid peroxide easily provides antioxidant activity in external oxidation.

[0037] embodiment described herein and other embodiment all only are that demonstration example and not being taken in the four corner of compositions among the present invention and method provides constraints.To particular, material, the equivalence of compositions and method changes, and revises and changes all to fall into scope of the present invention, and have basic similarly result.

Claims (29)

1. treatment, the composition for oral cavity of inhibition or minimizing oral inflammation comprises:

Comprise epigallocatechin gallate (EGCG), the total catechin at least about 50% and at least about the Camellia extract of 60% total polyphenols at least about 30%; With

Basic water insoluble non-cationic anti-bacterial.

2. composition for oral cavity according to claim 1, it further comprises the vitamin E more than about 0.001% weight.

3. compositions according to claim 1, wherein vitamin E is the dl-alpha tocopherol.

4. compositions according to claim 1, wherein the amount of vitamin E about by weight 0.001% to about 5% is present in the compositions.

5. compositions according to claim 1, wherein the amount of vitamin E about by weight 0.1% to about 4% is present in the compositions.

6. compositions according to claim 1, wherein the amount of vitamin E about by weight 0.2% to about 2.5% is present in the composition for oral cavity.

7. compositions according to claim 1, wherein Camellia extract is the extract of Camellia sinensis tissue.

8. compositions according to claim 1, wherein Camellia extract derives from Camellia sinensis var.assamica, Camellia sinensis var.cambodiensis, Camellia sinensis var.dehungensis, at least a tissue among Camelliasinensis var.pubilimba and the Camellia sinensis var.sinensis.

9. compositions according to claim 1, wherein Camellia extract is present in the composition for oral cavity to about 20% weight with about 0.001%.

10. compositions according to claim 1, wherein Camellia extract is present in the composition for oral cavity to about 10% weight with about 0.01%.

11. a compositions according to claim 1, wherein Camellia extract is present in the composition for oral cavity to about 5% weight with about 0.01%.

12. a compositions according to claim 1, wherein Camellia extract is present in the composition for oral cavity to about 0.2% weight with about 0.1%.

13. a compositions according to claim 1, wherein the amount of Camellia extract in composition for oral cavity shows the minimum of anti-inflammatory activity less than Camellia extract when Camellia extract exists as the independent component that wherein has anti-inflammatory activity.

14. a compositions according to claim 1, wherein antibacterial is a halogenated diphenyl ether.

15. a compositions according to claim 14, wherein antibacterial is 2 ', 4,4 '-three chloro-2-hydroxyl-diphenyl ether.

16. a compositions according to claim 1, wherein composition for oral cavity comprises and being selected from by extract of magnolia, at least a plant extract in the group that Herba Rosmarini Officinalis extract and composition thereof is formed.

17. a compositions according to claim 16, plant extract wherein is a Herba Rosmarini Officinalis extract.

18. to the treatment of oral inflammation and at least a method in the inhibition, comprise that the oral cavity to patient that these needs are arranged applies the composition for oral cavity of effective dose, it comprises the epigallocatechin gallate (EGCG) that contains at least about 30%, total catechin at least about 50% and at least about the Camellia extract of 60% total polyphenols.

19. a method according to claim 18, wherein Camellia extract is present in the composition for oral cavity to about 0.2% weight with about 0.1%.

20. a method according to claim 18, wherein composition for oral cavity further comprises antibacterial.

21. a method according to claim 18, wherein antibacterial is 2 ', 4,4 '-three chloro-2-hydroxyl-diphenyl ether.

22. a method according to claim 18 further comprises being selected from by extract of magnolia, at least a plant extract in the group that Herba Rosmarini Officinalis extract and composition thereof is formed.

23. a method according to claim 22, plant extract wherein is a Herba Rosmarini Officinalis extract.

24. an oral care composition comprises:

Camellia extract; With

Vitamin E at least about 0.001% weight.

25. at least a to the treatment of oral inflammation and in suppressing, and the method for antioxidant activity is provided in the oral cavity by applying the composition for oral cavity of effective dose to the oral cavity that this people who needs or other animal patient are arranged, said composition comprises:

Contain epigallocatechin gallate (EGCG), the total catechin at least about 50% and at least about the Camellia extract of 60% total polyphenols at least about 30%; With

The halogenated diphenyl ether antibacterial.

26. a method according to claim 25, wherein Camellia extract is present in the composition for oral cavity to about 0.2% weight with about 0.1%.

27. a method according to claim 25, wherein antibacterial is 2 ', 4,4 '-three chloro-2-hydroxyl-diphenyl ether.

28. a method according to claim 25 further comprises being selected from by extract of magnolia, at least a plant extract in the group that Herba Rosmarini Officinalis extract and composition thereof is formed.

29. a method according to claim 28, plant extract wherein is a Herba Rosmarini Officinalis extract.