CN101112195A - Avermectin micro-emulsion and method for preparing the same - Google Patents
Avermectin micro-emulsion and method for preparing the same Download PDFInfo
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- CN101112195A CN101112195A CNA2007100530135A CN200710053013A CN101112195A CN 101112195 A CN101112195 A CN 101112195A CN A2007100530135 A CNA2007100530135 A CN A2007100530135A CN 200710053013 A CN200710053013 A CN 200710053013A CN 101112195 A CN101112195 A CN 101112195A
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Abstract
The invention provides a micro-emulsion of avermectins and preparation method thereof. The micro-emulsion comprises avermectins of 1-8 percent, solvent 1-20 percent, cosolvent of 1-10 percent, surfactant of 1-20 percent, stabilizer of 3-15 percent and the rest is water. The preparation of the micro-emulsion of avermectins is divided into the following steps: (1) the avermectins is dissolved in a homogenizer with the solvent and the cosolvent; (2) the surfactant, the stabilizer and the water are added to the homogenizer and then are mixed seriously and homogenized, then the transparent micro-emulsion of avermectins is obtained. The obtained micro-emulsion of avermectins has high disinsection capacity and is capable of reducing environment pollution effectively.
Description
Technical field:
The present invention relates to a kind of avermectin micro-emulsion and preparation method thereof, belong to the antibiotic insecticide field.
Background technology:
Avermectin is a kind of efficient antibiotic insecticide of U.S. Mo Shadong research institute research and development, Yi Wei desinsection element in 1981 uses as animal body entozoa drug manufacture, and Avermectin in 1986 puts into production use as the control agent of crop pests, evil mite.Avermectin has mite class and insect tags and stomach poison function, and has the cross conduction osmosis.Its mechanism of action is different with general insecticide, mainly is the neurophysiology activity of interference insect, stimulates to discharge γ-An Jidingsuan, suppresses the conduction of the nerve impulse of insect.It has certain osmosis on the plant tissue blade, easily by biological degradation, do not have accumulation in environment.
At present existing how tame plant produced Avermectin, its product mostly is cream preparation.Cream preparation all mainly adopts the aromatic organic solvent preparation at home and abroad.Owing to aromatic organic solvent such as benzene,toluene,xylene, mix toluene etc. the pollution problem of environment and the harm of operator be restricted, the trend that is under an embargo and uses is arranged at some national aromatic organic solvents, particularly on vegetables, fruit tree, use the missible oil of aromatic organic solvent preparation, resisted consumingly.After missible oil class preparation adds water and is prepared into spray liquor in addition, promptly become emulsion, pesticide active ingredient is dissolved in the organic solvent, and emulsified dispersion becomes very thin oil droplet, and its diameter is usually at the 0.1-1.0 micron.Emulsion causes this formulation drug effect low at plant leaf surface and insect surfaces wetting and spreading weak effect, and control efficiency is poor, and having is the microemulsion of matrix and the trend that aqueous emulsion progressively replaces with water.For this efficient pesticides of Avermectin, the fineness that adopts the preparation method of microemulsion can improve oil droplet improves the effective rate of utilization of Avermectin, gives full play to its power.
Summary of the invention:
The purpose of this invention is to provide a kind of avermectin micro-emulsion and preparation method thereof, the present invention is not using aromatic organic solvent and is reducing the drug effect that the Avermectin microemulsion for preparing on the basis of other consumption of organic solvent can be given full play to Avermectin, strengthen its desinsection and render a service, and can effectively reduce environmental pollution.
Realize that the technical scheme that the object of the invention adopted is: a kind of avermectin micro-emulsion, it is characterized in that: each component of microemulsion and percentage by weight thereof are Avermectin 1-8%, solvent 1-20%, cosolvent 1-10%, surfactant 1-20%, stabilizing agent 3-15%, all the other are water, wherein solvent is an ethanol, propyl alcohol, butanols, isobutanol, amylalcohol, hexanol, enanthol, octanol, isooctanol, cyclohexanone, N-Methyl pyrrolidone, the N-octylpyrrolidone, the alkyl chain carbon atomicity is a kind of in the alkyl methyl esters of 6-18 or some kinds, cosolvent is a pentane, hexane, cyclohexane, heptane, octane, isooctane, a kind of in the benzinum or some kinds, surfactant is a polyoxyethylene polyoxypropylene block copolymer, fatty alcohol-polyoxyethylene ether, rope uncle SOPA, phenethyl phenol polyethenoxy formaldehyde condensation products, the alkyl polyoxyethylene formaldehyde condensation products, neopelex, dodecyl sodium sulfate, lauryl sodium sulfate, lauryl alcohol polyethylene glycol oxide sodium sulphate, sorbitan fatty acid ester, sodium lignin sulfonate, soil temperature 60, soil temperature 80, sorbester p17, a kind of in suffering/polyoxyethylene nonylphenol ether or some kinds, stabilizing agent is an ethylene glycol, propane diols, glycerine, polyethylene glycol, urea, sodium salicylate, a kind of in the sodium taurocholate or some kinds.
Described avermectin micro-emulsion is produced by following steps:
(1) Avermectin is dissolved in the homogenizer that solvent and cosolvent are housed;
(2) mix strongly and homogenize after joining surfactant and stabilizing agent, water in the homogenizer that above-mentioned solution is housed, obtain the as clear as crystal avermectin micro-emulsion of outward appearance at last.
Described Avermectin is the former medicine of Avermectin.
Described solvent is that ethanol, propyl alcohol, butanols, isobutanol, amylalcohol, hexanol, enanthol, octanol, isooctanol, cyclohexanone, N-Methyl pyrrolidone, N-octylpyrrolidone, alkyl chain carbon atomicity are the mixture of a kind of in the alkyl methyl esters of 6-18 or some kinds.
Described cosolvent is the mixture of a kind of in pentane, hexane, cyclohexane, heptane, octane, isooctane, the benzinum or some kinds.
Described surfactant is a polyoxyethylene polyoxypropylene block copolymer, fatty alcohol-polyoxyethylene ether, rope uncle SOPA, phenethyl phenol polyethenoxy formaldehyde condensation products, the alkyl polyoxyethylene formaldehyde condensation products, neopelex, dodecyl sodium sulfate, lauryl sodium sulfate, lauryl alcohol polyethylene glycol oxide sodium sulphate, sorbitan fatty acid ester, sodium lignin sulfonate, soil temperature 60, soil temperature 80, sorbester p17, OPEO, the mixture of a kind of in the polyoxyethylene nonylphenol ether or some kinds.
Described stabilizing agent is the mixture of a kind of in ethylene glycol, propane diols, glycerine, polyethylene glycol, urea, sodium salicylate, the sodium taurocholate or some kinds.
Compared with prior art, the present invention has the following advantages:
(1) contain 45～60% aromatic organic solvent in the conventional cream preparation, the avermectin micro-emulsion of the present invention's preparation does not contain aromatic organic solvent, has reduced environmental pollution significantly.
When (2) being mixed with sprinkling emulsion with conventional cream preparation, its oil droplet fineness is 0.1～1.0 micron, and its oil droplet fineness of sprinkling emulsion of microemulsion preparation is 0.005～0.01 micron, is lower than 0.005 micron and has approached true solution.Therefore improved pesticide active ingredient Avermectin and the dispersity of composite adjuvant in emulsion thereof, made emulsion approach true solution, thereby strengthened the penetrating ability of Avermectin, improved control efficiency, improved availability simultaneously insect and plant.
Embodiment:
Embodiment 1
Get the former medicine 1.5kg of Avermectin, place the mixed solvent of 6.5kg isooctanol and 5kg N-Methyl pyrrolidone and 1kg benzinum, the dissolving back adds 8.5kg alkyl polyoxyethylene formaldehyde condensation products, 2.3kg sldium lauryl sulfate and 1kg soil temperature 80 and 3.5kg ethylene glycol, 2.2kg urea and 68.5kg dispersion medium water mix in the homogenizer that above-mentioned solution is housed strongly and homogenize, obtains 1.5% as clear as crystal avermectin micro-emulsion of outward appearance at last.
Embodiment 2
Get the former medicine 3kg of Avermectin, place the mixed solvent of 15kg isobutanol and 4kg isooctane, the dissolving back adds 13.3kg OPEO and 1.7kg neopelex and 10kg sodium salicylate and 53kg dispersion medium water mixes in the homogenizer that above-mentioned solution is housed strongly and homogenize, obtains 3% as clear as crystal avermectin micro-emulsion of outward appearance at last.
Embodiment 3
Get the former medicine 5kg of Avermectin, place the mixed solvent of 13kg n-octyl alcohol and 1.7kg N-octylpyrrolidone and 3.3kg cyclohexane, the dissolving back adds 10kg polyoxyethylene nonylphenol ether, 3.5kg alkyl polyoxyethylene formaldehyde condensation products, 1.5kg dodecyl sodium sulfate and 1kg ethylene glycol, 5kg sodium salicylate and 56kg dispersion medium water and mixes strongly in the homogenizer that above-mentioned solution is housed and homogenize, obtains 5% as clear as crystal avermectin micro-emulsion of outward appearance at last.
Embodiment 4
Get the former medicine 8kg of Avermectin, place the mixed solvent of 13kg n-octyl alcohol and 4.5kgN-methyl pyrrolidone and 4kg isooctane, the dissolving back adds 13kg alkyl polyoxyethylene formaldehyde condensation products, 3.5kg sorbester p17 and 2.5kg sodium lignin sulfonate and 1.5kg glycerine, 10kg urea and 40kg dispersion medium water mix in the homogenizer that above-mentioned solution is housed strongly and homogenize, obtains 8% as clear as crystal avermectin micro-emulsion of outward appearance at last.
Claims (8)
1. avermectin micro-emulsion, it is characterized in that: each component of microemulsion and percentage by weight thereof are Avermectin 1-8%, solvent 1-20%, cosolvent 1-10%, surfactant 1-20%, stabilizing agent 3-15%, all the other are water, wherein solvent is an ethanol, propyl alcohol, butanols, isobutanol, amylalcohol, hexanol, enanthol, octanol, isooctanol, cyclohexanone, N-Methyl pyrrolidone, the N-octylpyrrolidone, the alkyl chain carbon atomicity is the mixture of a kind of in the alkyl methyl esters of 6-18 or some kinds, cosolvent is a pentane, hexane, cyclohexane, heptane, octane, isooctane, the mixture of a kind of in the benzinum or some kinds, surfactant is a polyoxyethylene polyoxypropylene block copolymer, fatty alcohol-polyoxyethylene ether, rope uncle SOPA, phenethyl phenol polyethenoxy formaldehyde condensation products, the alkyl polyoxyethylene formaldehyde condensation products, neopelex, dodecyl sodium sulfate, lauryl sodium sulfate, lauryl alcohol polyethylene glycol oxide sodium sulphate, sorbitan fatty acid ester, sodium lignin sulfonate, soil temperature 60, soil temperature 80, sorbester p17, the mixture of a kind of in suffering/polyoxyethylene nonylphenol ether or some kinds, stabilizing agent is an ethylene glycol, propane diols, glycerine, polyethylene glycol, urea, sodium salicylate, the mixture of a kind of in the sodium taurocholate or some kinds.
2. avermectin micro-emulsion according to claim 1 is characterized in that: Avermectin is the former medicine of Avermectin.
3. the preparation method of the described avermectin micro-emulsion of claim 1 is characterized in that adopting following steps:
(1) Avermectin is dissolved in the homogenizer that solvent and cosolvent are housed;
(2) mix strongly and homogenize after joining surfactant and stabilizing agent, water in the homogenizer that above-mentioned solution is housed, obtain the as clear as crystal avermectin micro-emulsion of outward appearance at last.
4. the preparation method of avermectin micro-emulsion according to claim 3, it is characterized in that: Avermectin is the former medicine of Avermectin.
5. the preparation method of avermectin micro-emulsion according to claim 3 is characterized in that: solvent is that ethanol, propyl alcohol, butanols, isobutanol, amylalcohol, hexanol, enanthol, octanol, isooctanol, cyclohexanone, N-Methyl pyrrolidone, N-octylpyrrolidone, alkyl chain carbon atomicity are the mixture of a kind of in the alkyl methyl esters of 6-18 or some kinds.
6. the preparation method of avermectin micro-emulsion according to claim 3 is characterized in that: cosolvent is the mixture of a kind of in pentane, hexane, cyclohexane, heptane, octane, isooctane, the benzinum or some kinds.
7. the preparation method of avermectin micro-emulsion according to claim 3, it is characterized in that: surfactant is a polyoxyethylene polyoxypropylene block copolymer, fatty alcohol-polyoxyethylene ether, rope uncle SOPA, phenethyl phenol polyethenoxy formaldehyde condensation products, the alkyl polyoxyethylene formaldehyde condensation products, neopelex, dodecyl sodium sulfate, lauryl sodium sulfate, lauryl alcohol polyethylene glycol oxide sodium sulphate, sorbitan fatty acid ester, sodium lignin sulfonate, soil temperature 60, soil temperature 80, sorbester p17, OPEO, the mixture of a kind of in the polyoxyethylene nonylphenol ether or some kinds.
8. the preparation method of avermectin micro-emulsion according to claim 3 is characterized in that: stabilizing agent is the mixture of a kind of in ethylene glycol, propane diols, glycerine, polyethylene glycol, urea, sodium salicylate, the sodium taurocholate or some kinds.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007100530135A CN101112195A (en) | 2007-08-22 | 2007-08-22 | Avermectin micro-emulsion and method for preparing the same |
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| CNA2007100530135A CN101112195A (en) | 2007-08-22 | 2007-08-22 | Avermectin micro-emulsion and method for preparing the same |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102132698A (en) * | 2010-01-21 | 2011-07-27 | 中化化工科学技术研究总院 | Green solvent for pesticide and application of green solvent |
| CN102318623A (en) * | 2011-10-14 | 2012-01-18 | 青岛金正农药有限公司 | Abamectin aqueous missible oil and preparation method thereof |
| CN102696641A (en) * | 2012-06-18 | 2012-10-03 | 吕昆明 | Molluscicide for Pomacea canaliculata and production method for molluscicide |
| CN102885060A (en) * | 2012-09-29 | 2013-01-23 | 华南农业大学 | Avermectin nanometer microemulsion and preparation method thereof |
| CN103651418A (en) * | 2013-12-30 | 2014-03-26 | 青岛崂乡茶制品有限公司 | Novel pesticide for tea trees |
| CN104705316A (en) * | 2013-12-16 | 2015-06-17 | 天津迈迪瑞康生物医药科技有限公司 | Abamectin microemulsion concentrate and preparation method and application thereof |
| WO2015114590A1 (en) * | 2014-02-03 | 2015-08-06 | Pacific Agrosciencies S.A.I.C. | Liquid non-aqueous pesticide composition, method for preparing the liquid non-aqueous pesticide composition and method for eliminating insects, acarids and nematodes in cultures |
| CN105145636A (en) * | 2015-06-08 | 2015-12-16 | 诺农(北京)国际生物技术有限公司 | Doramectin-biological source composite microemulsion and preparation method thereof |
| WO2015196925A1 (en) * | 2014-06-24 | 2015-12-30 | Rotam Agrochem International Company Limited | Agrochemical formulation, method making, and method of using |
| CN109452269A (en) * | 2018-12-21 | 2019-03-12 | 硅羿科技（上海）有限公司 | Avermectin emulsion formulations and preparation method and application |
| CN111011373A (en) * | 2019-12-26 | 2020-04-17 | 安徽云中生态农业开发有限公司 | Composite pesticide for controlling broccoli |
-
2007
- 2007-08-22 CN CNA2007100530135A patent/CN101112195A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102132698A (en) * | 2010-01-21 | 2011-07-27 | 中化化工科学技术研究总院 | Green solvent for pesticide and application of green solvent |
| CN102318623A (en) * | 2011-10-14 | 2012-01-18 | 青岛金正农药有限公司 | Abamectin aqueous missible oil and preparation method thereof |
| CN102696641A (en) * | 2012-06-18 | 2012-10-03 | 吕昆明 | Molluscicide for Pomacea canaliculata and production method for molluscicide |
| CN102885060A (en) * | 2012-09-29 | 2013-01-23 | 华南农业大学 | Avermectin nanometer microemulsion and preparation method thereof |
| CN104705316A (en) * | 2013-12-16 | 2015-06-17 | 天津迈迪瑞康生物医药科技有限公司 | Abamectin microemulsion concentrate and preparation method and application thereof |
| CN103651418A (en) * | 2013-12-30 | 2014-03-26 | 青岛崂乡茶制品有限公司 | Novel pesticide for tea trees |
| WO2015114590A1 (en) * | 2014-02-03 | 2015-08-06 | Pacific Agrosciencies S.A.I.C. | Liquid non-aqueous pesticide composition, method for preparing the liquid non-aqueous pesticide composition and method for eliminating insects, acarids and nematodes in cultures |
| WO2015196925A1 (en) * | 2014-06-24 | 2015-12-30 | Rotam Agrochem International Company Limited | Agrochemical formulation, method making, and method of using |
| CN105145636A (en) * | 2015-06-08 | 2015-12-16 | 诺农(北京)国际生物技术有限公司 | Doramectin-biological source composite microemulsion and preparation method thereof |
| CN105145636B (en) * | 2015-06-08 | 2018-02-23 | 诺农(北京)国际生物技术有限公司 | A kind of doractin and biogenic substances complex microemulsion and preparation method thereof |
| CN109452269A (en) * | 2018-12-21 | 2019-03-12 | 硅羿科技（上海）有限公司 | Avermectin emulsion formulations and preparation method and application |
| CN109452269B (en) * | 2018-12-21 | 2021-06-01 | 硅羿科技（上海）有限公司 | Abamectin emulsion preparation and preparation method and application thereof |
| CN111011373A (en) * | 2019-12-26 | 2020-04-17 | 安徽云中生态农业开发有限公司 | Composite pesticide for controlling broccoli |
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