CN101104048B - Compound medicine for pulse generating and treating coronary heart disease - Google Patents
Compound medicine for pulse generating and treating coronary heart disease Download PDFInfo
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- CN101104048B CN101104048B CN200610045491A CN200610045491A CN101104048B CN 101104048 B CN101104048 B CN 101104048B CN 200610045491 A CN200610045491 A CN 200610045491A CN 200610045491 A CN200610045491 A CN 200610045491A CN 101104048 B CN101104048 B CN 101104048B
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Abstract
The invention belongs to the medication technical field, which discloses the medicine and the preparation method for treating the coronary heart disease and miocardial infarction. The medicine is mainly prepared from ginseng root, dwarf lilyturf tuber, Chinese magnoliavine fruit, radix astragali and Chinese angelica, or ginseng root, dwarf lilyturf tuber, Chinese magnoliavine fruit, radix astragali, Chinese angelica, cassia twig and liquorice, or ginseng root, dwarf lilyturf tuber, Chinese magnoliavine fruit, radix astragali, Chinese angelica, cassia twig, liquorice, danshen root, red peony root, radix notoginseng and safflower, according to certain ratios of weights. The invention can be made to any type of medicament that can be accepted by the clinic or pharmacology, which is the good quality oral preparation. The medicine has effects of Qi-replenishing, Yin-nourishing and pulse-invigorating and blood circulation activating to dissipate blood stasis and lipid lowing, which can be used to curing the chest distress, hard breathe, heart-throb, angina and arrhythmia caused by coronary heart disease and miocardial infarction, the recovery period of the cerebral thrombosis and the sequelae of the cerebral thrombosis, the effects are obvious.
Description
1, technical field
The present invention relates to a kind of medicine for the treatment of coronary heart disease, myocardial infarction and preparation method thereof, belong to medical technical field.
2, background technology
Coronary heart disease belongs to the traditional Chinese medical science " thoracic obstruction ", " pained " category, be a kind of commonly encountered diseases and frequently-occurring disease of the serious harm human health that causes owing to the human body coronary insufficiency, be to cause the first dead killer, and M ﹠ M is ascendant trend year by year.In China, evidence of coronary heart diseases and mortality rate also are the trend that rises year by year.At present, doctor trained in Western medicine stresses the alleviation of acute symptom to coronary heart disease class treatment of diseases more, the treatment of the cause of disease is lacked effective means, and toxic and side effects is bigger; Chinese traditional treatment coronary heart disease class disease has medicines such as FUFANG DANSHEN PIAN, DANQI PIAN, but has defectives such as medication is not comprehensive, onset is slow, curative effect is low, often needs and the Western medicine drug combination.Therefore it is evident in efficacy to press for research and development, the new Chinese medicine that toxic and side effects is little.
Radix Ginseng is the dry root and rhizome of Araliaceae Radix Ginseng Panax ginseng C.A.Mey..Sweet, little hardship, flat.Return spleen, lung, heart channel.Strongly invigorating primordial QI is arranged, and multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, the effect of calming the nerves.Be used for weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, and prolonged illness is empty wins, palpitation with fear insomnia, sexual impotence cold womb, heart failure, cardiogenic shock.
Be the dried root of liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (Thunb.) Ker-Gawl. Radix Ophiopogonis.Sweet, little hardship is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting is arranged, the effect that lung moistening clears away heart-fire.Be used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, the dryness of the intestine constipation; Pharyngeal diphtheria.
Fructus Schisandrae Chinensis is the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill..Acid, sweet, temperature.Return lung, the heart, kidney channel.There is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, the effect of kidney calming.Be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
The Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.Var.mongholicus (Bge.) Hsiso or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Sweet, warm.Return spleen, lung meridian.Invigorating QI to consolidate the body surface resistance is arranged, diuresis poison holding, evacuation of pus, the effect of expelling pus and promoting granulation.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.
When the dry root that is classified as umbelliferae angelica Angelica sinensis (Oliv.) Diels.Sweet, hot, temperature.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus; Menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Ramulus Cinnamomi is the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Hot, sweet, temperature.GUIXIN, lung, urinary bladder channel.The diaphoresis expelling pathogenic factors from muscles is arranged, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the effect of the flat gas that spins.Be used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Clycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Clycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Clycyrrhiza glabra L..Sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI is arranged, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge.. bitter, be slightly cold. and GUIXIN, Liver Channel. stasis-dispelling and pain-killing is arranged, promoting blood circulation to restore menstrual flow, the effect of relieving restlessness clears away heart-fire. be used for menoxenia, the amenorrhea dysmenorrhea, little abdominal mass is gathered, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Radix Paeoniae Rubra is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.Hardship is slightly cold.Return Liver Channel.Clearing away heat and cooling blood is arranged, the effect of eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, amenorrhea dysmenorrhea, note of the ancient Chinese abdominal mass stomachache, injury from falling down, carbuncle skin infection.
Radix Notoginseng is the dry root and rhizome of panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen.Sweet, little hardship, temperature.Attach to the lung and stomach meridians.The dissipating blood stasis hemostasis is arranged, the effect of subduing swelling and relieving pain.Be used for spitting of blood, spit blood, epistaxis is had blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.
Flos Carthami is the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Suffering, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow is arranged, eliminating stasis to stop pain.Be used for amenorrhea, dysmenorrhea, lochia is not all right, note of the ancient Chinese abdominal mass mass in the abdomen, injury from falling down, skin infection swells and ache.
At present, utilize Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali and Radix Angelicae Sinensis, or Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi and Radix Glycyrrhizae, or the interaction of Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Notoginseng and Flos Carthami, composition of prescription, be used to prepare the medicine of treatment coronary heart disease, myocardial infarction, do not appear in the newspapers as yet.
3, summary of the invention
In order to meet clinical needs, enlarge medicine variety, the invention provides that a kind of prescription science, preparation are simple, determined curative effect be used for the treatment of medicine of cardiovascular and cerebrovascular disease and preparation method thereof.
The traditional Chinese medical science is thought, heart master blood, and the motive promotes blood and moves in heart arteries and veins.If deficiency of qi and blood, then the operation of the blood of the heart is not smooth, so that stasis of blood resistance heart arteries and veins, forms the thoracic obstruction.We's medicine is got it and is invigorated vital energy and reinforce the heart, the merit of YIN nourishing and the production of body fluid promoting based on SHENGMAI SAN; Be equipped with the treatise on Febrile Diseases Ramuli Cinnamomi and Glycyrrhizae Decoction, Ramulus Cinnamomi is gone into the heart, warming the meridian for promoting the flow of YANG QI, and blood vessel dilating, blood circulation promoting, angry blood is changed in the invigorating middle warmer of Radix Glycyrrhizae Preparata QI invigorating, and with multiple feeling pulse originally, Xin Gan share, with multiple heart-yang; Radix Angelicae Sinensis decoction for tonifying blood, Radix Astragali QI invigorating and blood producing, Chinese angelica blood supplementing is invigorated blood circulation, and share qi-supplementing, blood-engendering, gas-solid blood is filled; Also be equipped with the key medicine of invigorating blood circulation in the side, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Paeoniae Rubra and Flos Carthami, four energy blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia.All medicines share, and play the promote blood circulation effect of blood circulation promoting and blood stasis dispelling blood fat reducing of supplementing QI and nourishing YIN altogether.
Medicine of the present invention is made up of following bulk drugs:
5～15 parts of Radix Ginsengs, 5～15 parts of Radix Ophiopogonis, 1～10 part of Fructus Schisandrae Chinensis, 5～25 parts of the Radixs Astragali, 1～20 part of Radix Angelicae Sinensis.
The weight portion of each component of medicine of the present invention is preferably:
10 parts of Radix Ginsengs, 10 parts of Radix Ophiopogonis, 6 parts of Fructus Schisandrae Chinensis, 15 parts of the Radixs Astragali, 9 parts of Radix Angelicae Sinensis.
The preparation method of medicine of the present invention is as follows:
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, the Radix Angelicae Sinensis of described weight portion, standby;
2) people who weighs up is participated in alcohol reflux, merge extractive liquid, filters, and filtrate recycling ethanol does not stir evenly to having the alcohol flavor, adding water in right amount, and cold preservation is left standstill, and filters, and filtrate is concentrated into thick paste;
3) Radix Angelicae Sinensis and the Fructus Schisandrae Chinensis that weighs up extracted volatile oil with steam distillation, with the oven dry of beta-schardinger dextrin-inclusion, standby; Collect water liquid, medicinal residues decoct with water with the Radix Ophiopogonis and the Radix Astragali, and merge extractive liquid, filters, and filtrate is concentrated into finite concentration, precipitate with ethanol, and cold preservation is left standstill, and filters, and decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized and the beta-cyclo dextrin included compound of volatile oil mixes, and gets active constituents of medicine of the present invention.
In the above-mentioned preparation method, preferred steps is:
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, the Radix Angelicae Sinensis of described weight portion, standby;
2) people who weighs up is participated in 70% alcohol reflux three times, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add for the second time 6 times of amounts of alcohol, refluxed 1 hour, add 6 times of amounts of alcohol for the third time, refluxed 1 hour, merge extractive liquid, filters, filtrate recycling ethanol is to there not being the alcohol flavor, add water to an amount of (making every 1ml be equivalent to crude drug 1.5g), stir evenly, cold preservation was left standstill 24 hours, filter, filtrate is concentrated into thick paste;
3) water that the Radix Angelicae Sinensis that weighs up and Fructus Schisandrae Chinensis are added 10 times of amounts extracted 8 hours with steam distillation, collect volatile oil, (getting beta-schardinger dextrin-is dissolved in and makes into saturated solution in the suitable quantity of water with the beta-schardinger dextrin-inclusion, inject volatile oil, high-speed stirred 2 hours, cold preservation left standstill 24 hours, filtered), 60 ℃ of dry inclusion complexes, standby; Collect water liquid, medicinal residues and Radix Ophiopogonis and the Radix Astragali decoct with water secondary, all add 6 times of amounts of water at every turn, decocted 2 hours, collecting decoction filters, it is 1.10～1.12 that filtrate is concentrated into relative density, and adding ethanol is 65% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.12～1.15, adding ethanol is 75% precipitate with ethanol to containing the alcohol amount, cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized and the beta-cyclo dextrin included compound of volatile oil mixes, and gets active constituents of medicine of the present invention.
Each amounts of components of medicine of the present invention can also be:
5～15 parts of Radix Ginsengs, 5～15 parts of Radix Ophiopogonis, 1～10 part of Fructus Schisandrae Chinensis, 5～25 parts of the Radixs Astragali, 1～20 part of Radix Angelicae Sinensis, 5～20 parts of Ramulus Cinnamomi, 1～10 part in Radix Glycyrrhizae.
The weight portion of each component is preferably:
10 parts of Radix Ginsengs, 10 parts of Radix Ophiopogonis, 6 parts of Fructus Schisandrae Chinensis, 15 parts of the Radixs Astragali, 9 parts of Radix Angelicae Sinensis, 12 parts of Ramulus Cinnamomi, 6 parts in Radix Glycyrrhizae.
Pharmaceutical preparation of the present invention is as follows:
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi and the Radix Glycyrrhizae of described weight portion, standby;
2) people who weighs up is participated in alcohol reflux, merge extractive liquid, filters, and filtrate recycling ethanol does not stir evenly to having the alcohol flavor, adding water in right amount, and cold preservation is left standstill, and filters, and filtrate is concentrated into thick paste;
3) Radix Angelicae Sinensis and the Fructus Schisandrae Chinensis that weighs up extracted volatile oil with steam distillation, with the oven dry of beta-schardinger dextrin-inclusion, standby; Collect water liquid, medicinal residues decoct with water with Radix Ophiopogonis, the Radix Astragali, Ramulus Cinnamomi and Radix Glycyrrhizae, and merge extractive liquid, filters, and filtrate is concentrated into finite concentration, precipitate with ethanol, and cold preservation is left standstill, and filters, and decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized and the beta-cyclo dextrin included compound of volatile oil mixes, and gets active constituents of medicine of the present invention.
In the above-mentioned preparation method, preferred steps is:
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi and the Radix Glycyrrhizae of described weight portion, standby;
2) people who weighs up is participated in 70% alcohol reflux three times, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add for the second time 6 times of amounts of alcohol, refluxed 1 hour, add 6 times of amounts of alcohol for the third time, refluxed 1 hour, merge extractive liquid, filters, filtrate recycling ethanol is to there not being the alcohol flavor, add water to an amount of (making every 1ml be equivalent to crude drug 1.5g), stir evenly, cold preservation was left standstill 24 hours, filter, filtrate is concentrated into thick paste;
3) water that the Radix Angelicae Sinensis that weighs up and Fructus Schisandrae Chinensis are added 10 times of amounts extracted 8 hours with steam distillation, collect volatile oil, (getting beta-schardinger dextrin-is dissolved in and makes into saturated solution in the suitable quantity of water with the beta-schardinger dextrin-inclusion, inject volatile oil, high-speed stirred 2 hours, cold preservation left standstill 24 hours, filtered), 60 ℃ of dry inclusion complexes, standby; Collect water liquid, medicinal residues and Radix Ophiopogonis, the Radix Astragali, Ramulus Cinnamomi and Radix Glycyrrhizae decoct with water secondary, all add 6 times of amounts of water at every turn, decocted 2 hours, collecting decoction filters, it is 1.10～1.12 that filtrate is concentrated into relative density, and adding ethanol is 65% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.12～1.15, adding ethanol is 75% precipitate with ethanol to containing the alcohol amount, cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized and the beta-cyclo dextrin included compound of volatile oil mixes, and gets active constituents of medicine of the present invention.
The further consumption of each component of medicine of the present invention is:
5～15 parts of Radix Ginsengs, 5～15 parts of Radix Ophiopogonis, 1～10 part of Fructus Schisandrae Chinensis, 5～25 parts of the Radixs Astragali, 1～20 part of Radix Angelicae Sinensis, 5～20 parts of Ramulus Cinnamomi, 1～10 part in Radix Glycyrrhizae, 5～25 parts of Radix Salviae Miltiorrhizaes, 1～20 part of Radix Paeoniae Rubra, 1～20 part of Radix Notoginseng, 1～10 part on Flos Carthami.
The parts by weight of each component are preferably:
10 parts of Radix Ginsengs, 10 parts of Radix Ophiopogonis, 6 parts of Fructus Schisandrae Chinensis, 15 parts of the Radixs Astragali, 9 parts of Radix Angelicae Sinensis, 12 parts of Ramulus Cinnamomi, 6 parts in Radix Glycyrrhizae, 15 parts of Radix Salviae Miltiorrhizaes, 9 parts of Radix Paeoniae Rubra, 9 parts of Radix Notoginseng, 6 parts on Flos Carthami.
Pharmaceutical preparation of the present invention is as follows:
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, the Radix Notoginseng and Flos Carthami of described weight portion, standby;
2) Radix Ginseng and the Radix Notoginseng that weighs up added alcohol reflux, merge extractive liquid, filters, and filtrate recycling ethanol does not stir evenly to having the alcohol flavor, adding water in right amount, and cold preservation is left standstill, and filters, and filtrate is concentrated into thick paste;
3) Radix Angelicae Sinensis and the Fructus Schisandrae Chinensis that weighs up extracted volatile oil with steam distillation, with the oven dry of beta-schardinger dextrin-inclusion, standby; Collect water liquid, medicinal residues decoct with water with Radix Ophiopogonis, the Radix Astragali, Ramulus Cinnamomi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Flos Carthami and Radix Paeoniae Rubra, and merge extractive liquid, filters, and filtrate is concentrated into finite concentration, precipitate with ethanol, and cold preservation is left standstill, and filters, and decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized and the beta-cyclo dextrin included compound of volatile oil mixes, and gets active constituents of medicine of the present invention.
In the above-mentioned preparation method, preferred steps is:
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, the Radix Notoginseng and Flos Carthami of described weight portion, standby;
2) Radix Ginseng and the Radix Notoginseng that weighs up added 70% alcohol reflux three times, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add for the second time 6 times of amounts of alcohol, refluxed 1 hour, add 6 times of amounts of alcohol for the third time, refluxed 1 hour, merge extractive liquid, filters, filtrate recycling ethanol is to there not being the alcohol flavor, add water to an amount of (making every 1ml be equivalent to crude drug 1.5g), stir evenly, cold preservation was left standstill 24 hours, filter, filtrate is concentrated into thick paste;
3) water that the Radix Angelicae Sinensis that weighs up and Fructus Schisandrae Chinensis are added 10 times of amounts extracted 8 hours with steam distillation, collect volatile oil, (getting beta-schardinger dextrin-is dissolved in and makes into saturated solution in the suitable quantity of water with the beta-schardinger dextrin-inclusion, inject volatile oil, high-speed stirred 2 hours, cold preservation left standstill 24 hours, filtered), 60 ℃ of dry inclusion complexes, standby; Collect water liquid, medicinal residues and Radix Ophiopogonis, the Radix Astragali, Ramulus Cinnamomi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Flos Carthami and Radix Paeoniae Rubra decoct with water secondary, all add 6 times of amounts of water at every turn, decocted 2 hours, collecting decoction, filter, it is 1.10～1.12 that filtrate is concentrated into relative density, and adding ethanol is 65% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.12～1.15, adding ethanol is 75% precipitate with ethanol to containing the alcohol amount, cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized and the beta-cyclo dextrin included compound of volatile oil mixes, and gets active constituents of medicine of the present invention.
The crude drug of medicine of the present invention is by weight as proportioning, when producing, can or reduce according to the corresponding proportion increase, as large-scale production can kilogram be unit, or be unit with the ton, small-scale production also can restrain and be unit, and weight can increase or reduce. and screening obtains the weight proportion of medicine material medicine of the present invention through science, for especial patient, can be corresponding the ratio formed of adjustment, increase or reduce being no more than 100%.
Medicine of the present invention has the promote blood circulation effect of blood circulation promoting and blood stasis dispelling blood fat reducing of supplementing QI and nourishing YIN, be used for that coronary heart disease, myocardial infarction etc. cause uncomfortable in chest, breathe hard, cardiopalmus, angina pectoris, arrhythmia and cerebral thrombosis recovery phase and cerebral infarction sequela.
Medicine of the present invention can be mixed and made into clinically any or pharmaceutically acceptable dosage form, preferred oral preparation with one or more pharmaceutically acceptable carriers.When being applied to the patient who needs this treatment in the mode of oral administration, can be made into conventional solid preparation, as tablet, capsule, soft capsule, dispersible tablet, chewable tablet, oral cavity disintegration tablet, oral liquid, granule, drop pill, slow releasing tablet, slow releasing capsule, controlled release tablet, controlled release capsule etc.
When medicine of the present invention is made preparation, the conventional method production in the existing pharmaceutical field can be adopted, various pharmaceutically acceptable carriers can be added when needing.Described carrier comprises diluent, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant of pharmaceutical field routine etc.
Medicine of the present invention is when making oral formulations, and selectable filler has: starch, Icing Sugar, calcium phosphate, calcium sulfate two water things, dextrin, microcrystalline Cellulose, lactose, pregelatinized Starch, mannitol etc.; Selectable binding agent has: sodium carboxymethyl cellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose, hypromellose, gelling starch etc.; Selectable disintegrating agent has: dried starch, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose etc.; Selectable lubricant has: magnesium stearate, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
The advantage of medicine of the present invention is:
(1) provides a kind of medicine that is used to prepare treatment myocardial infarction, coronary heart disease, increased the clinical application kind, satisfied clinical needs.
(2) medicine of the present invention shows by pharmacological evaluation, rat experiment myocardial inyaretion area is reduced, anticoagulant, reduce and tried dog heart rate (HR), mean arterial pressure (MBP), left indoor pressure (LVP) and ventricular muscles contractility (dp/dtmax), myocardial oxygen consumption all have the reduction effect, and curative effect that our medicine reaches is that the inventor did not expect.
(3) pharmaceutical preparation of the present invention is simple, and mass discrepancy is little between the different batches medicine, and drug quality is uniform and stable.
Below example is further set forth by Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis (returning to call living arteries and veins in the following text) by experiment, or Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Glycyrrhizae (to call living arteries and veins osmanthus in the following text), or the beneficial effect of the medicine made of Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Notoginseng and Flos Carthami (to call living arteries and veins pellet in the following text).
Experimental example 1: medicine of the present invention is to the influence of rat experiment myocardial inyaretion scope
Animal subject: the Wistar rat, male, body weight 200～220g, is divided into 4 groups, 10 every group at random by 40.
Test sample: give birth to arteries and veins and return basic, normal, high dosage group, self-control
Experimental technique: rat is divided into 4 groups at random: model group, give birth to arteries and veins and return basic, normal, high three dosage groups.Each medicine group gastric infusion.
Rat experiment myocardial inyaretion model: it is fixing that animal pentobarbital intraperitoneal injection of anesthesia (45mg/kg) is faced upward the position.Tracheal intubation is made the longitudinal incision of 2cm in breastbone left side, nearly breastbone side is cut off the 3rd, the 4th costicartilage, open the thoracic cavity after, connect artificial respirator (ventilation 2ml/100g, 50 times/min).Cut off pericardium, expose heart, left anterior descending coronary artery root threading is in order to ligation, and record standard II lead electrocardiogram was stablized 10 minutes, and the ligation left anterior descending coronary artery is closed the thoracic cavity.With syringe sucking-off animal throat secretions, make animal recover autonomous respiration.Behind the ligation coronary artery 15min, intravenously administrable.Behind the ligation coronary artery 4 hours, win heart, 5 of the following crosscuts of ligature, carry out chlorination nitro blue tetrazolium (N-BT) dyeing, calculating myocardium infraction plug district area accounts for the percentage ratio of ventricle and heart area, and carries out statistical procedures (t check).The results are shown in Table 1.
Table 1 medicine of the present invention is to the influence of rat experiment myocardial inyaretion scope (x ± sD)
Annotate:
*P＜0.01 is compared with model group.
Experimental result and conclusion: the results are shown in Table 1.
By the result as seen, compare, give birth to arteries and veins and return each dosage group myocardial infarction area all significantly to reduce (p＜0.01) with model group.Show that the medicine that Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis compatibility are made can significantly reduce myocardial infarction area, and above each component medicine compatibility effect is remarkable.
Experimental example 2: medicine of the present invention is to the hemodynamic influence of anesthetized open-chest dog
Experimental animal: hybrid dog, 20, body weight 11.2～13.5kg.
Test sample: blank group: sodium chloride injection (Shangdong Changfu Jiejing Pharmaceutical Industry Co., Ltd.)
Give birth to the basic, normal, high dosage group in arteries and veins osmanthus, self-control
Test method: dog is divided into 4 groups at random, 5 every group, is respectively the blank group, gives birth to the basic, normal, high dosage group in arteries and veins osmanthus.Dog is taked under the right arm reclining malleation artificial respiration after anaesthetizing with pentobarbital sodium (30mg/kg) intravenous injection, opens breast between 4～5 sides of body of a left side, opens pericardium in distance vagus nerve 2cm place, and parietal layer is made outstanding bed it is sutured in thoracic wall, and heart is fully exposed.Separate aorta, aortic root be inserted in the electromagnetic flowmeter probe (10～12mm), measure cardiac output (CO); At the left anterior descending coronary artery root, separate visceral pericardium, isolate about 1cm coronary artery, be inserted in the electromagnetic flowmeter probe (2～3mm), measurement coronary flow (CBF); This two probe is connected on the LMTC-621 type electromagnetic flowmeter, separates a bilateral common carotid artery, intubate connects pressure transducer, record arteriotony (AP) and mean arterial pressure (MAP); With internal diameter is that the cardiac catheter of 1.5mm is inserted left ventricle from the apex of the heart, amplify left indoor pressure (LVP) by YZ-1 type pressure transducer through carrier wave, the LVP electric signal amplifies 10 times through direct current amplifier, write down left chamber EDP (LVEDP), with the LVP electric signal again through BMI type differentiator derivative recording left indoor pressure rate of change (dp/dt
Max), it is subcutaneous to insert the animal subject extremity with pin type electrode, and record mark II lead electrocardiogram (EGG-II) is to measure heart rate (HR).These parameters changes equal synchronous recording and leads instrument in RM-6300 physiology more.
Separate femoral artery and take out arterial blood, through External Carotid Artery for Intubation to the coronary sinus vein venous blood samples, according to CY-2 oxygen analyser operation instructions, add the anhydrous sodium sulfite crystallization with freshly prepared anaerobic solution (0.01M) borax soln and be mixed with 2% sodium sulfite solution zeroing, use with the distilled water of air balance temperature constant and make sensitivity adjusting.Treat to measure oxygen content with oxygen analyser behind the instrument stabilizer.Calculating myocardium oxygen consumption after the off-test.
After operation finishes, observe above-mentioned every index, after stable with the index of record value before as administration, behind the intravenously administrable in 1,3,5,10,20,30min, gather above-mentioned every index, and with every index rate of change (%) of each time point after the administration, the t-test that does significance pairing data between group with every index rate of change (%) of each corresponding time point of matched group handles.
Result of the test and conclusion: give birth to each dosage group of arteries and veins osmanthus to being tried dog heart rate (HR), mean arterial pressure (MBP), left indoor pressure (LVP) and ventricular muscles contractility (dp/dtmax), myocardial oxygen consumption all have the reduction effect, with matched group the curative effect (p＜0.01) of highly significant is arranged relatively, show, give birth to the hematodinamics that anesthetized open-chest dog can be well improved in arteries and veins osmanthus.
Experimental example 3: medicine antiplatelet aggregative activity of the present invention
Animal subject: the Wistar rat, male, body weight 200～220g, is divided into 4 groups, 10 every group at random by 40.
Test sample: blank group: sodium chloride injection (Shangdong Changfu Jiejing Pharmaceutical Industry Co., Ltd.)
Give birth to red high, medium and low three the dosage groups of arteries and veins
Experimental technique: rat is divided into 4 groups at random, 10 every group, be respectively the blank group, give birth to the red high, medium and low dosage group of arteries and veins.Each treated animal intraperitoneal injection, once a day, successive administration 7 days, after the last administration 1 hour, from abdominal aortic blood, anticoagulant adopted 3.28% sodium citrate after the Animal Anesthesia, with blood with 1: 9 mixed.With anticoagulated whole blood 1500rmin under 20 ℃ of conditions
-1Centrifugal 5min obtains platelet rich plasma (PRP).After leaving and taking quantitative PRP, will remain PRP once more with 3000rmin
-1Centrifugal 10min obtains own control platelet poor plasma (PPP).Regulate PRP concentration with PPP, make each PRP concentration identical.In 37 ℃ constant temperature hole after the preheating, (final concentration is 3 μ molL to add ADP with PRP
-1) cause and write down maximum agglutination rate by platelet aggregation.The results are shown in Table 3.
Table 3 antiplatelet aggregative activity (X ± SD)
Annotate:
*P＜0.05,
*P＜0.01 is compared with the blank group
Experimental result and conclusion: experimental result sees Table 3.
By the result as seen, compare with the blank group, give birth to all obvious anticoagulant (p＜0.05 of energy of red three the dosage groups of arteries and veins, p＜0.01), show, the medicine of being made by Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Notoginseng and Flos Carthami compatibility is platelet aggregation significantly, and blood stasis dispelling is promoted blood circulation, and then the generation of anti-cardiovascular disease.
4, the specific embodiment
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following embodiment.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1: the preparation of medicinal tablet of the present invention
Radix Ginseng 600g 600g Radix Ophiopogonis Fructus Schisandrae Chinensis 360g Radix Astragali 900g Radix Angelicae Sinensis 540g
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, the Radix Angelicae Sinensis of described weight portion, standby;
2) people who weighs up is participated in 70% alcohol reflux three times, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add for the second time 6 times of amounts of alcohol, refluxed 1 hour, add 6 times of amounts of alcohol for the third time, refluxed 1 hour, merge extractive liquid, filters, filtrate recycling ethanol is to there not being the alcohol flavor, add water to an amount of (making every 1ml be equivalent to crude drug 1.5g), stir evenly, cold preservation was left standstill 24 hours, filter, filtrate is concentrated into thick paste;
3) water that the Radix Angelicae Sinensis that weighs up and Fructus Schisandrae Chinensis are added 10 times of amounts extracted 8 hours with steam distillation, collect volatile oil, (getting beta-schardinger dextrin-is dissolved in and makes into saturated solution in the suitable quantity of water with the beta-schardinger dextrin-inclusion, inject volatile oil, high-speed stirred 2 hours, cold preservation left standstill 24 hours, filtered), 60 ℃ of dry inclusion complexes, standby; Collect water liquid, medicinal residues and Radix Ophiopogonis and the Radix Astragali decoct with water secondary, all add 6 times of amounts of water at every turn, decocted 2 hours, collecting decoction filters, it is 1.10～1.12 that filtrate is concentrated into relative density, and adding ethanol is 65% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.12～1.15, adding ethanol is 75% precipitate with ethanol to containing the alcohol amount, cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized and the beta-cyclo dextrin included compound of volatile oil mixes, and adds binding agent, disintegrating agent and lubricant and makes granule, and drying is pressed into 1000.
Embodiment 2: the preparation of medicine capsule of the present invention
Radix Ginseng 450g 450g Radix Ophiopogonis Fructus Schisandrae Chinensis 270g Radix Astragali 675g Radix Angelicae Sinensis 400g Ramulus Cinnamomi 550g Radix Glycyrrhizae 270g
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi and the Radix Glycyrrhizae of described weight portion, standby;
2) people who weighs up is participated in 70% alcohol reflux three times, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add for the second time 6 times of amounts of alcohol, refluxed 1 hour, add 6 times of amounts of alcohol for the third time, refluxed 1 hour, merge extractive liquid, filters, filtrate recycling ethanol is to there not being the alcohol flavor, add water to an amount of (making every 1ml be equivalent to crude drug 1.5g), stir evenly, cold preservation was left standstill 24 hours, filter, filtrate is concentrated into thick paste;
3) water that the Radix Angelicae Sinensis that weighs up and Fructus Schisandrae Chinensis are added 10 times of amounts extracted 8 hours with steam distillation, collect volatile oil, (getting beta-schardinger dextrin-is dissolved in and makes into saturated solution in the suitable quantity of water with the beta-schardinger dextrin-inclusion, inject volatile oil, high-speed stirred 2 hours, cold preservation left standstill 24 hours, filtered), 60 ℃ of dry inclusion complexes, standby; Collect water liquid, medicinal residues and Radix Ophiopogonis, the Radix Astragali, Ramulus Cinnamomi and Radix Glycyrrhizae decoct with water secondary, all add 6 times of amounts of water at every turn, decocted 2 hours, collecting decoction filters, it is 1.10～1.12 that filtrate is concentrated into relative density, and adding ethanol is 65% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.12～1.15, adding ethanol is 75% precipitate with ethanol to containing the alcohol amount, cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized and the beta-cyclo dextrin included compound of volatile oil mixes, and adds binding agent and makes granule, dresses up 1000 hard capsules.
Embodiment 3: the preparation of medicinal granule of the present invention
Radix Ginseng 300g 300g Radix Ophiopogonis Fructus Schisandrae Chinensis 180g Radix Astragali 450g Radix Angelicae Sinensis 270g
Ramulus Cinnamomi 360g Radix Glycyrrhizae 180g Radix Salviae Miltiorrhizae 450g Radix Paeoniae Rubra 270g Radix Notoginseng 270g
Flos Carthami 180g
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, the Radix Notoginseng and Flos Carthami of described weight portion, standby;
2) Radix Ginseng and the Radix Notoginseng that weighs up added 70% alcohol reflux three times, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add for the second time 6 times of amounts of alcohol, refluxed 1 hour, add 6 times of amounts of alcohol for the third time, refluxed 1 hour, merge extractive liquid, filters, filtrate recycling ethanol is to there not being the alcohol flavor, add water to an amount of (making every 1ml be equivalent to crude drug 1.5g), stir evenly, cold preservation was left standstill 24 hours, filter, filtrate is concentrated into thick paste;
3) water that the Radix Angelicae Sinensis that weighs up and Fructus Schisandrae Chinensis are added 10 times of amounts extracted 8 hours with steam distillation, collect volatile oil, (getting beta-schardinger dextrin-is dissolved in and makes into saturated solution in the suitable quantity of water with the beta-schardinger dextrin-inclusion, inject volatile oil, high-speed stirred 2 hours, cold preservation left standstill 24 hours, filtered), 60 ℃ of dry inclusion complexes, standby; Collect water liquid, medicinal residues and Radix Ophiopogonis, the Radix Astragali, Ramulus Cinnamomi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Flos Carthami and Radix Paeoniae Rubra decoct with water secondary, all add 6 times of amounts of water at every turn, decocted 2 hours, collecting decoction, filter, it is 1.10～1.12 that filtrate is concentrated into relative density, and adding ethanol is 65% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.12～1.15, adding ethanol is 75% precipitate with ethanol to containing the alcohol amount, cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized and the beta-cyclo dextrin included compound of volatile oil mixes, and adding Icing Sugar, binding agent are made 1000 bag granules.
Embodiment 4: the preparation of medicinal soft capsule of the present invention
Radix Ginseng 600g 600g Radix Ophiopogonis Fructus Schisandrae Chinensis 350g Radix Astragali 900g Radix Angelicae Sinensis 550g
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, the Radix Angelicae Sinensis of described weight portion, standby;
2) people who weighs up is participated in 70% alcohol reflux three times, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add for the second time 6 times of amounts of alcohol, refluxed 1 hour, add 6 times of amounts of alcohol for the third time, refluxed 1 hour, merge extractive liquid, filters, filtrate recycling ethanol is to there not being the alcohol flavor, add water to an amount of (making every 1ml be equivalent to crude drug 1.5g), stir evenly, cold preservation was left standstill 24 hours, filter, filtrate is concentrated into thick paste;
3) water that the Radix Angelicae Sinensis that weighs up and Fructus Schisandrae Chinensis are added 10 times of amounts extracted 8 hours with steam distillation, collect volatile oil, (getting beta-schardinger dextrin-is dissolved in and makes into saturated solution in the suitable quantity of water with the beta-schardinger dextrin-inclusion, inject volatile oil, high-speed stirred 2 hours, cold preservation left standstill 24 hours, filtered), 60 ℃ of dry inclusion complexes, standby; Collect water liquid, medicinal residues and Radix Ophiopogonis and the Radix Astragali decoct with water secondary, all add 6 times of amounts of water at every turn, decocted 2 hours, collecting decoction filters, it is 1.10～1.12 that filtrate is concentrated into relative density, and adding ethanol is 65% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.12～1.15, adding ethanol is 75% precipitate with ethanol to containing the alcohol amount, cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized and the beta-cyclo dextrin included compound of volatile oil mixes, must the invention active constituents of medicine, and with soybean oil and soybean phospholipid, Cera Flava heating and melting, mixing is put coldly, adds the gained active component, is pressed into 1000 soft capsules.
Embodiment 5: the preparation of medicinal dropping ball of the present invention
Radix Ginseng 450g 450g Radix Ophiopogonis Fructus Schisandrae Chinensis 275g Radix Astragali 675g Radix Angelicae Sinensis 400g Ramulus Cinnamomi 550g Radix Glycyrrhizae 275g
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi and the Radix Glycyrrhizae of described weight portion, standby;
2) people who weighs up is participated in 70% alcohol reflux three times, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add for the second time 6 times of amounts of alcohol, refluxed 1 hour, add 6 times of amounts of alcohol for the third time, refluxed 1 hour, merge extractive liquid, filters, filtrate recycling ethanol is to there not being the alcohol flavor, add water to an amount of (making every 1ml be equivalent to crude drug 1.5g), stir evenly, cold preservation was left standstill 24 hours, filter, filtrate is concentrated into thick paste;
3) water that the Radix Angelicae Sinensis that weighs up and Fructus Schisandrae Chinensis are added 10 times of amounts extracted 8 hours with steam distillation, collect volatile oil, (getting beta-schardinger dextrin-is dissolved in and makes into saturated solution in the suitable quantity of water with the beta-schardinger dextrin-inclusion, inject volatile oil, high-speed stirred 2 hours, cold preservation left standstill 24 hours, filtered), 60 ℃ of dry inclusion complexes, standby; Collect water liquid, medicinal residues and Radix Ophiopogonis, the Radix Astragali, Ramulus Cinnamomi and Radix Glycyrrhizae decoct with water secondary, all add 6 times of amounts of water at every turn, decocted 2 hours, collecting decoction filters, it is 1.10～1.12 that filtrate is concentrated into relative density, and adding ethanol is 65% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.12～1.15, adding ethanol is 75% precipitate with ethanol to containing the alcohol amount, cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry, pulverize, mix with the beta-cyclo dextrin included compound of volatile oil, must the invention active constituents of medicine, with polyethylene glycol 6000 heating and melting in water-bath, treat to add the gained active component after whole fusions, stirring and dissolving, 60 mesh sieves are filtered, and keep 60 ℃ to splash in the liquid paraffin that is chilled to below 10 ℃ and make ball.
Claims (10)
1. a medicine for the treatment of coronary heart disease myocardial infarction is characterized in that, this medicine is made by following bulk drugs: 5～15 parts of Radix Ginsengs, 5～15 parts of Radix Ophiopogonis, 1～10 part of Fructus Schisandrae Chinensis, 5～25 parts of the Radixs Astragali, 1～20 part of Radix Angelicae Sinensis.
2. medicine according to claim 1 is characterized in that, the parts by weight of this each crude drug of medicine are: 10 parts of Radix Ginsengs, 10 parts of Radix Ophiopogonis, 6 parts of Fructus Schisandrae Chinensis, 15 parts of the Radixs Astragali, 9 parts of Radix Angelicae Sinensis.
3. the preparation method of arbitrary medicine according to claim 1 and 2, it comprises the following steps:
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, the Radix Angelicae Sinensis of described weight portion, standby;
2) people who weighs up is participated in alcohol reflux, merge extractive liquid, filters, and filtrate recycling ethanol does not stir evenly to having the alcohol flavor, adding water in right amount, and cold preservation is left standstill, and filters, and filtrate is concentrated into thick paste;
3) Radix Angelicae Sinensis and the Fructus Schisandrae Chinensis that weighs up extracted volatile oil with steam distillation, with the oven dry of beta-schardinger dextrin-inclusion, standby; Collect water liquid, medicinal residues decoct with water with the Radix Ophiopogonis and the Radix Astragali, and merge extractive liquid, filters, and filtrate is concentrated into finite concentration, precipitate with ethanol, and cold preservation is left standstill, and filters, and decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized and the beta-cyclo dextrin included compound of volatile oil mixes, and gets active constituents of medicine of the present invention.
4. medicine for the treatment of coronary heart disease myocardial infarction, it is characterized in that this medicine is made by following bulk drugs: 5～15 parts of Radix Ginsengs, 5～15 parts of Radix Ophiopogonis, 1～10 part of Fructus Schisandrae Chinensis, 5～25 parts of the Radixs Astragali, 1～20 part of Radix Angelicae Sinensis, 5～20 parts of Ramulus Cinnamomi, 1～10 part in Radix Glycyrrhizae.
5. medicine according to claim 4 is characterized in that, the parts by weight of this each crude drug of medicine are: 10 parts of Radix Ginsengs, 10 parts of Radix Ophiopogonis, 6 parts of Fructus Schisandrae Chinensis, 15 parts of the Radixs Astragali, 9 parts of Radix Angelicae Sinensis, 12 parts of Ramulus Cinnamomi, 6 parts in Radix Glycyrrhizae.
6. according to the preparation method of claim 4 or 5 described arbitrary medicines, it comprises the following steps:
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi and the Radix Glycyrrhizae of described weight portion, standby;
2) people who weighs up is participated in alcohol reflux, merge extractive liquid, filters, and filtrate recycling ethanol does not stir evenly to having the alcohol flavor, adding water in right amount, and cold preservation is left standstill, and filters, and filtrate is concentrated into thick paste;
3) Radix Angelicae Sinensis and the Fructus Schisandrae Chinensis that weighs up extracted volatile oil with steam distillation, with the oven dry of beta-schardinger dextrin-inclusion, standby; Collect water liquid, medicinal residues decoct with water with Radix Ophiopogonis, the Radix Astragali, Ramulus Cinnamomi and Radix Glycyrrhizae, and merge extractive liquid, filters, and filtrate is concentrated into finite concentration, precipitate with ethanol, and cold preservation is left standstill, and filters, and decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized and the beta-cyclo dextrin included compound of volatile oil mixes, and gets active constituents of medicine of the present invention.
7. medicine for the treatment of coronary heart disease myocardial infarction is characterized in that this medicine made by following bulk drugs: 5～15 parts of Radix Ginsengs, 5～15 parts of Radix Ophiopogonis, 1～10 part of Fructus Schisandrae Chinensis, 5～25 parts of the Radixs Astragali, 1～20 part of Radix Angelicae Sinensis, 5～20 parts of Ramulus Cinnamomi, 1～10 part in Radix Glycyrrhizae, 1～20 part of Radix Paeoniae Rubra, 1～20 part of Radix Notoginseng, 1～10 part on Flos Carthami, 5～25 parts of Radix Salviae Miltiorrhizaes.
8. medicine according to claim 7, it is characterized in that the parts by weight of this each crude drug of medicine are: 10 parts of Radix Ginsengs, 10 parts of Radix Ophiopogonis, 6 parts of Fructus Schisandrae Chinensis, 15 parts of the Radixs Astragali, 9 parts of Radix Angelicae Sinensis, 12 parts of Ramulus Cinnamomi, 6 parts in Radix Glycyrrhizae, 15 parts of Radix Salviae Miltiorrhizaes, 9 parts of Radix Paeoniae Rubra, 9 parts of Radix Notoginseng, 6 parts on Flos Carthami.
9. according to the preparation method of claim 7 or 8 described arbitrary medicines, it comprises the following steps:
1) take by weighing Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, the Radix Notoginseng and Flos Carthami of described weight portion, standby;
2) Radix Ginseng and the Radix Notoginseng that weighs up added alcohol reflux, merge extractive liquid, filters, and filtrate recycling ethanol does not stir evenly to having the alcohol flavor, adding water in right amount, and cold preservation is left standstill, and filters, and filtrate is concentrated into thick paste;
3) Radix Angelicae Sinensis and the Fructus Schisandrae Chinensis that weighs up extracted volatile oil with steam distillation, with the oven dry of beta-schardinger dextrin-inclusion, standby; Collect water liquid, medicinal residues decoct with water with Radix Ophiopogonis, the Radix Astragali, Ramulus Cinnamomi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Flos Carthami and Radix Paeoniae Rubra, and merge extractive liquid, filters, and filtrate is concentrated into finite concentration, precipitate with ethanol, and cold preservation is left standstill, and filters, and decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized and the beta-cyclo dextrin included compound of volatile oil mixes, and gets active constituents of medicine of the present invention.
10. according to claim 1,2,4,5,7,8 described arbitrary medicines, it is characterized in that this medicine can be made oral formulations with mixing acceptable accessories.
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| CN103239688A (en) * | 2013-05-27 | 2013-08-14 | 陈瑶 | Traditional Chinese medicine for treating coronary heart disease and preparation method of traditional Chinese medicine |
| CN103768249A (en) * | 2013-12-31 | 2014-05-07 | 广东先强药业股份有限公司 | Capsules for treating myocarditis and preparation method thereof |
| CN104258049A (en) * | 2014-10-24 | 2015-01-07 | 樊冬梅 | Traditional Chinese medicine composition for treating myocardial infarction |
| CN104398809A (en) * | 2014-11-09 | 2015-03-11 | 朱海燕 | Traditional Chinese medicine composition for treating coronary heart disease, preparation method and applications thereof |
| CN104474503A (en) * | 2014-11-27 | 2015-04-01 | 桂林瑞丰环保微生物应用研究所 | Traditional Chinese medicine preparation for regulating qi-blood |
| CN104940597A (en) * | 2015-07-27 | 2015-09-30 | 青岛蓝盛洋医药生物科技有限责任公司 | Chinese herbal composition used for treating myocardial infarction, and preparation method of Chinese herbal composition |
| CN104940554A (en) * | 2015-07-27 | 2015-09-30 | 李万青 | Chinese herbal composition for treating heart diseases |
| CN106237066A (en) * | 2016-08-25 | 2016-12-21 | 西安必康制药集团有限公司 | A kind of medicine of supporing yang QI invigorating and yin nourishing and preparation method thereof |
| CN108079060A (en) * | 2018-01-30 | 2018-05-29 | 青岛市中心医院 | It is a kind of to blend together preparation and preparation method for Internal Medicine-Cardiovascular Dept. clinic |
| CN110183505B (en) * | 2019-04-19 | 2020-06-26 | 牡丹江医学院 | Medicine for improving cardiac ST segment change caused by myocardial infarction |
| CN114129659A (en) * | 2022-01-19 | 2022-03-04 | 郭正方 | Traditional Chinese medicine formula for treating palpitation and thoracic obstruction |
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| CN1356138A (en) * | 2001-09-27 | 2002-07-03 | 孔金立 | Medicine for treating cardiovascular and cerebrovascular diseases of old people |
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