CN101095753A - Chinese medicine preparation for treating diabetic hyperlipaemia - Google Patents

Abstract

The invention relates to a Chinese medicinal composition for treating diabetic hyperlipoidemia, which is prepared from more than ten kinds of Chinese medicinal herbs including Loranthus mulberry mistletoe, wolferry fruit, chicken's gizzard-skin and earthworm. The medicament has the advantages of assured curative effect, safe and convenient application, no toxic and side effects, and low price.

Description

A kind of Chinese medicine preparation of treatment diabetes hyperlipaemia

Technical field

The present invention relates to treat a kind of Chinese medicine preparation of diabetes hyperlipaemia, is that a kind of diabetes hyperlipaemia for the treatment of is the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

The concentration of triacylglycerol in diabetics blood plasma or the serum (TG), cholesterol (TC), phospholipid (PL), cholesteryl ester (CE) and non-esterified fatty acid (NEFA) exceeds normal range, is called hyperlipemia.Hyperlipemia sickness rate in diabetic population is very high, 25% has hypercholesterolemia 30% cholesterol to reach critical high value among the U.S. adult according to statistics, shows that U.S. adult is hyperlipemia more than 50%.Diabetes are owing to carbohydrate metabolism disturbance causes disorders of lipid metabolism, and are no matter all very common in IDDM still is NIDDM patient.China's data points out that hyperlipemia accounts for 43% among the untreated NIDDM, and wherein the overweight people reaches 54%.A large amount of clinical and experimentatioies confirm that hyperlipemia is the primary factor that causes atherosclerosis (AS), and arteriosclerosis is the main cause of facilitating coronary heart disease, cerebrovascular.The non-diabetic hyperlipidemia incidence is 20%～40%, and diabetes merge hyperlipemia person up to 60%～70%.Diabetes are died from atherosclerosis person and are reached 80%.1989 ADA (ADA) think that three big risk factors of diabetes generation macroangiopathy are hypertension, hyperlipidemia and smoking.Therefore, the hyperlipidemia of actively preventing and treating diabetics is to reducing vascular complication, and it is significant to reduce mortality rate.Hyperlipemia by its clinical symptoms, is under the jurisdiction of the category of Chinese medicine " phlegm syndrome " " damp syndrome ".By its body constitution, be to be " body of phlegm-damp ", expectorant is the main paathogenic factor that causes the body of phlegm-damp with wetting.Sick position is at spleen, kidney.The generation of the body of phlegm-damp is relevant with multiple factors such as diet, internal injury, diseases caused by exogenous pathogenic factor, body constitution, causes and stops in the turbid damp, accumulates one-tenth expectorant of a specified duration.Expectorant is called together with gas phase with wet, draws altogether for suffering from.The traditional Chinese medical science divide clinically phlegm-fire fight knot, hoodwink clearly key, the resistance of cold-phlegm numbness, turbid yin cover on key, stagnation of dampness due to deficiency of the spleen, the wind-phlegm disturb, disease type Coryza Treated by Syndrome Differentiation such as heart deficiency of spleen-YANG, the turbid resistance network of expectorant, obtain very good effect.Invent a kind of not only safety but also effective Chinese medicine preparation, be significant.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of diabetes hyperlipaemia.Have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by the following weight proportion raw material:

1.5～6 parts of 1.5～6 portions of Rhizoma Alismatis of 1.5～6 parts of Herba Taxillis of Radix Polygoni Multiflori

1.0～4 parts of 1.0～4 parts of Radix Salviae Miltiorrhizaes of 1.0～4 parts of Cortex Eucommiae of Fructus Lycii

1.0～4 parts of 1.0～4 parts of Flos Chrysanthemis of 1.0～4 parts of Semen Cassiaes of Fructus Crataegi

0.1～2 part of 0.1～2 part of Pheretima of 0.1～2 part of Flos Sophorae of Endothelium Corneum Gigeriae Galli.

The weight proportion of each raw material of optimization formula of the present invention is:

2.5～3.5 parts of 2.5～3.5 portions of Rhizoma Alismatis of 2.5～3.5 parts of Herba Taxillis of Radix Polygoni Multiflori

1.5～2.5 parts of 1.5～2.5 parts of Radix Salviae Miltiorrhizaes of 1.5～2.5 parts of Cortex Eucommiae of Fructus Lycii

1.5～2.5 parts of 1.5～2.5 parts of Flos Chrysanthemis of 1.5～2.5 parts of Semen Cassiaes of Fructus Crataegi

0.5～1.5 part of 0.5～1.5 part of Pheretima of 0.5～1.5 part of Flos Sophorae of Endothelium Corneum Gigeriae Galli.

The weight proportion of each raw material of optimum formula of the present invention is:

3 parts of 3 portions of Rhizoma Alismatis of 3 parts of Herba Taxillis of Radix Polygoni Multiflori

2 parts of 2 parts of Radix Salviae Miltiorrhizaes of 2 parts of Cortex Eucommiae of Fructus Lycii

2 parts of 2 parts of Flos Chrysanthemis of 2 parts of Semen Cassiaes of Fructus Crataegi

1 part of 1 part of Pheretima of 1 part of Flos Sophorae of Endothelium Corneum Gigeriae Galli.

Drug action mechanism among the present invention is as follows:

Radix Polygoni Multiflori property of medicine hardship, sweet, puckery, tepor.Return liver, the heart, kidney channel.Have nourishing the blood and yin, loosening bowel to relieve constipation dispels the wind, the antidotal effect.Can treat Light-headedness, cardiopalmus, insomnia, soreness of the waist and knees, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, chronic malaria body void, rubella pruritus, carbuncle sore, scrofula, hemorrhoid etc.(the 1588th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Herba Taxilli property of medicine hardship, sweet, flat.Return liver, kidney channel.Has invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive effect.Can treat soreness of waist and knee joint, a little less than the muscles and bones flaccidity, limbs are hemiplegia, rheumatic arthralgia, and Light-headedness is had blood in stool, frequent fetal movement, metrostaxis, lack of lactation after delivery etc.(the 2789th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Rhizoma Alismatis property of medicine is sweet, light, and is cold.Return kidney, urinary bladder channel.Have promoting diuresis to eliminate damp pathogen, treating stranguria effect expels the heat-evil.Can treat dysuria, the puckery pain of pyretic stranguria, the edema distension is had loose bowels, dizziness due to fluid-retention, seminal emission etc.(the 2067th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Fructus Lycii property of medicine is sweet, flat.Return liver, kidney, lung meridian.Has nourishing the liver, nourishing kidney, the effect of lung moistening.Can treat caused by liver and kidney deficiency, have a dizzy spell, visual unclear, soreness of the waist and knees, impotence and seminal emission, cough due to consumptive disease, the taking fluids profusely etc. of quenching one's thirst.(the 2248th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Sweet, the little suffering of the Cortex Eucommiae property of medicine, temperature.Return liver, kidney channel.Has invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect.Can treat soreness of waist and knee joint, sexual impotence, frequent micturition, dribbling urination, rheumatic arthralgia, frequent fetal movement, habitual abortion etc.(the 1514th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Salviae Miltiorrhizae property of medicine hardship is slightly cold.GUIXIN, pericardium, Liver Channel.Have blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, relieving restlessness is calmed the nerves, the effect of removing heat from blood eliminating carbuncle.Can treat menoxenia, dysmenorrhea, amenorrhea, the stasis of blood stagnated and suffered from abdominal pain puerperal, trusted subordinate's pain, lumps in the chest and abdomen, pyretic arthralgia swells and ache, traumatic injury, heat is gone into nutrient blood, dysphoria, vexed insomnia, carbuncle pyogenic infections from tumour or sore etc.(the 647th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The acid of the Fructus Crataegi property of medicine, sweet tepor.Return spleen, stomach, Liver Channel.Has promoting digestion and invigorating the stomach, the effect of circulation of qi promoting dissipating blood stasis.Can treat eating accumulation, abdominal distention, dysentery, dysmenorrhea due to blood stasis, amenorrhea, puerperal abdonimal pain, lochiorrhea, hernia or painful and swollen testis, hyperlipemia etc.(the 226th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Semen Cassiae property of medicine hardship, sweet, salty is slightly cold.Return liver, kidney, large intestine channel.Has liver heat removing and eyesight improving, the effect of diuretic treatment constipation.Can treat conjunctival congestion and swelling pain, photophobia tear is many, optic atrohic blindness, nyctalopia, headache and dizzy, poor vision, tympanites, habitual constipation, toxic swelling, tinea disease etc.(the 1310th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Flos Chrysanthemi property of medicine is sweet, bitter, is slightly cold.Return lung, Liver Channel.Have wind and heat dispersing, suppressing the hyperactive liver makes eye bright, the effect of removing toxic substances and promoting subsidence of swelling.Can treat affection due to external wind and heat or pathogenic wind-warm from the beginning of, fever and headache, dizzy, conjunctival congestion and swelling pain, furuncle swelling toxin etc.(the 2900th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Endothelium Corneum Gigeriae Galli property of medicine is sweet, puckery, and is flat.Return spleen, stomach, urinary bladder channel.Have strengthening the spleen and stomach, it is long-pending to help digestion, the calculi dissolving effect.Can treat food stagnation, have loose bowels, infantile malnutrition, cholelithiasis, stranguria caused by urinary stone, sand Stranguria ， mass in the abdomen amenorrhea, sore throat tonsillitis, ulcerative gingivitis aphtha etc.(the 1684th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Flos Sophorae property of medicine hardship is slightly cold.Return liver, large intestine channel.Has cooling blood for hemostasis, the effect of liver heat removing and eyesight improving.Can treat discharging fresh blood stool, hemorrhoid hematochezia, dysentery with red and white feces, stranguria with blood, metrorrhagia, haematemesis, epistaxis, sore swollen toxin etc.(the 3440th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Pheretima nature and flavor are salty, cold.Go into liver, spleen, lung, urinary bladder channel.Have heat clearing away, suppressing the hyperactive liver, Zhichuan, collateral dredging diuretic effect.Cure mainly high fanatical dry, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pant, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection, hyperpyrexia, bronchial asthma, hypertension, psychosis, ulcer of the lower limb, eczema, erysipelas, burn and scald, fracture etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 522nd page).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Radix Polygoni Multiflori, Herba Taxilli and Rhizoma Alismatis; With Fructus Lycii, Cortex Eucommiae, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Cassiae and Flos Chrysanthemi is ministerial drug; With Endothelium Corneum Gigeriae Galli, Flos Sophorae and Pheretima is adjuvant.All medicines are harmonious, and are total to the tool liver and kidney tonifying, the effect of blood stasis dispelling blood fat reducing.The treatment diabetes hyperlipaemia has determined curative effect, has no side effect taking convenience, cheap characteristics.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of Pharmacopoeia of People's Republic of China, utilizes the comprehensive function treatment diabetes hyperlipaemia of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.

3, the present invention not only can effectively treat diabetes hyperlipaemia, and the prevention of diabetes hyperlipaemia is also had good effect, and the treatment diabetes hyperlipaemia has determined curative effect, has no side effect taking convenience, cheap characteristics.

For showing the therapeutic effect of medicine of the present invention, as follows through clinical test results to the treatment diabetes hyperlipaemia; Treatment diabetes hyperlipaemia patient 18 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Two months is a course of treatment, take continuously three the course of treatment observe the curative effect.9 examples of fully recovering account for 50%, and 6 examples that take a turn for the better account for 33.33%, and invalid 3 examples account for 16.67%, and total effective rate reaches 83.33%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

The embodiment decoction takes by weighing raw material by following weight:

3 parts of 3 portions of Rhizoma Alismatis of 3 parts of Herba Taxillis of Radix Polygoni Multiflori

2 parts of 2 parts of Radix Salviae Miltiorrhizaes of 2 parts of Cortex Eucommiae of Fructus Lycii

2 parts of 2 parts of Flos Chrysanthemis of 2 parts of Semen Cassiaes of Fructus Crataegi

1 part of 1 part of Pheretima of 1 part of Flos Sophorae of Endothelium Corneum Gigeriae Galli.

Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment diabetes hyperlipaemia that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.Two months is a course of treatment.

Claims (3)

1, a kind of Chinese medicine preparation of treatment diabetes hyperlipaemia is characterized in that it is made by the following weight proportion raw material:

1.5～6 parts of 1.5～6 portions of Rhizoma Alismatis of 1.5～6 parts of Herba Taxillis of Radix Polygoni Multiflori

1.0～4 parts of 1.0～4 parts of Radix Salviae Miltiorrhizaes of 1.0～4 parts of Cortex Eucommiae of Fructus Lycii

1.0～4 parts of 1.0～4 parts of Flos Chrysanthemis of 1.0～4 parts of Semen Cassiaes of Fructus Crataegi

0.1～2 part of 0.1～2 part of Pheretima of 0.1～2 part of Flos Sophorae of Endothelium Corneum Gigeriae Galli.

2, a kind of Chinese medicine preparation of treatment diabetes hyperlipaemia according to claim 1, wherein the weight proportion of each raw material is:

2.5～3.5 parts of 2.5～3.5 portions of Rhizoma Alismatis of 2.5～3.5 parts of Herba Taxillis of Radix Polygoni Multiflori

1.5～2.5 parts of 1.5～2.5 parts of Radix Salviae Miltiorrhizaes of 1.5～2.5 parts of Cortex Eucommiae of Fructus Lycii

1.5～2.5 parts of 1.5～2.5 parts of Flos Chrysanthemis of 1.5～2.5 parts of Semen Cassiaes of Fructus Crataegi

0.5～1.5 part of 0.5～1.5 part of Pheretima of 0.5～1.5 part of Flos Sophorae of Endothelium Corneum Gigeriae Galli.

3, a kind of Chinese medicine preparation of treatment diabetes hyperlipaemia according to claim 1, wherein the weight proportion of each raw material is:

3 parts of 3 portions of Rhizoma Alismatis of 3 parts of Herba Taxillis of Radix Polygoni Multiflori

2 parts of 2 parts of Radix Salviae Miltiorrhizaes of 2 parts of Cortex Eucommiae of Fructus Lycii

2 parts of 2 parts of Flos Chrysanthemis of 2 parts of Semen Cassiaes of Fructus Crataegi

1 part of 1 part of Pheretima of 1 part of Flos Sophorae of Endothelium Corneum Gigeriae Galli.