CN101088555B - Medicine preparation for inhibiting tumor angiogenesis and cancer cell and enhancing immunity - Google Patents
Medicine preparation for inhibiting tumor angiogenesis and cancer cell and enhancing immunity Download PDFInfo
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- CN101088555B CN101088555B CN2007100659292A CN200710065929A CN101088555B CN 101088555 B CN101088555 B CN 101088555B CN 2007100659292 A CN2007100659292 A CN 2007100659292A CN 200710065929 A CN200710065929 A CN 200710065929A CN 101088555 B CN101088555 B CN 101088555B
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Abstract
The Chinese medicine preparation is prepared with 16 kinds of Chinese medicinal materials, including malaytea scurfpea fruit, epimedium, angelica, astragalus root, bupleurum root, etc in certain weight proportion. It can raise the immunological function of human body cell, inhibit tumor angiogenesis, inhibiting tumor cell, clearing away heat and toxic material, etc, so as to prevent and treat cancers.
Description
Technical field
The present invention relates to a kind of preparation that suppresses tumor-blood-vessel growth and cancerous cell, raise immunity.
Background technology
Before the present invention puts forward, domestic existing like product effect is single, lifting or change only for a certain function, clinical trial only limits to examine basic laboratory or the fundamental test that authorities require, and in darker wider field product is not similar to the pharmacologic agent research of research and development medicine process.
Summary of the invention
Deficiency at above-mentioned existence, the present invention proposes a kind of preparation that suppresses tumor-blood-vessel growth and cancerous cell, raise immunity, it adopts scientific compatibility, determined curative effect, used medicine is natural Chinese medicinal herb, can improve the human body cell immunologic function, suppress the tumor neogenetic blood vessels growth, suppress tumor cell or growth of cancer cells.Heat-clearing and toxic substances removing, QI and blood regulating, supporting vital QI and dispersing blood stasis, elimination lump; By improving the human body cell immunologic function immune surveillance, the immune defence of tumor are engulfed and immune clearance, all kinds of cancers are carried out active treatment and prevention multi-facetedly.
Component of the present invention is: Fructus Psoraleae 25～60 grams, Herba Epimedii 22～56 grams, Radix Angelicae Sinensis 26～70 grams, the Radix Astragali 30～70 grams, Radix Bupleuri 15～35 grams, Cordyceps 36～54 grams, Radix Cirsii Japonici 20～55 grams, Rhizoma Curcumae 26～50 grams, Radix Curcumae 28～99 grams, Rhizoma Imperatae 21～50 grams, Flos Carthami 18～80 grams, Cortex Phellodendri 30～50 grams, the Rhizoma Atractylodis Macrocephalae 30～85 grams, Radix Scutellariae 30～82 grams, Herba Violae 30～69 grams, Radix Glycyrrhizae 17～45 grams.
Above component amounts to 16 materials, as calculating with the meticulous powder of crude drug in whole, adds up to net weight 404～1010 grams, the drug rate by 99.90%, and every capsules or tablet net weight are 0.4 gram, can produce 1000～2500 capsules or tablet.
Best component of the present invention is: Fructus Psoraleae 25 grams, Herba Epimedii 22 grams, Radix Angelicae Sinensis 26 grams, the Radix Astragali 30 grams, Radix Bupleuri 15 grams, Cordyceps 36 grams, Radix Cirsii Japonici 20 grams, Rhizoma Curcumae 26 grams, Radix Curcumae 28 grams, Rhizoma Imperatae 21 grams, Flos Carthami 18 grams, Cortex Phellodendri 30 grams, the Rhizoma Atractylodis Macrocephalae 30 grams, Radix Scutellariae 30 grams, Herba Violae 30 grams, Radix Glycyrrhizae 17 grams.More than amount to 16 materials, make 1000 capsules.
In the component of the present invention, each crude drug all is documented in the Chinese crude drug Quality Identification standard that relevant departments such as the Pharmacopoeia of the People's Republic of China (2000 edition) or domestic each province, city, district's health, drug and food supervision and management formulate; Used adjuvant is the conventional medicine additive that meets sanitary condition.
Processing technology of the present invention: at first Fructus Psoraleae, Herba Epimedii, Radix Angelicae Sinensis, the Radix Astragali, Radix Bupleuri, Cordyceps, Radix Cirsii Japonici, Rhizoma Curcumae, Radix Curcumae, Rhizoma Imperatae, Flos Carthami, Cortex Phellodendri, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae, Herba Violae, Radix Glycyrrhizae ten Six-element medical materials are roughly selected respectively, dry, mix the back coarse pulverization, essence is crushed to can be by the meticulous powder of No. six sieves, go up the traditional thread binding capsule shaping of capsule manufacture then, bottled packing, sterilization, warehouse-in.Or, promptly make capsule or tablet with the extract mixing of part spice in the meticulous powder of crude drug in whole and this component with two ginseng methods, finish sterilization at last.Manufactured goods keep moisture 4%～8%.
Above-mentioned preparation can be:
A, the meticulous powder of crude drug in whole are made capsule.
B, the meticulous powder of crude drug in whole and part medicament extract mixing capsule or be pressed into tablet, the component amount is constant.
The chemical compound of C, crude drug in whole extract, purification, the capsule that monomer component is made or tablet or oral liquid or injection.
Ten Six-element materials according to the present invention are made dosage forms such as soft capsule, capsule, tablet, syrup, oral liquid, granule, injection respectively with traditional handicraft or modern crafts.
Above-mentioned pharmaceutical formulation comprises all monomers, chemical compound, bioactive ingredients and all kinds of molecular cluster and the derivant of therefrom extracting through behind traditional handicraft and the application of new technology etc.
Theory of Chinese medical science is thought: " healthy energy internal memory and heresy can not do ".QI and blood, taste and kidney are formed three bursts of vigour that earn a bare living of vital functions in people's life system, the kidney being the origin of congenital constitution, and The spleen and stomach provide the material basis of the acquired, and QI and blood is for carrying the network of human nutrition.Component of the present invention is exactly by being in harmonious proportion three bursts of vigour of tonification people, controlling cancer anti-cancer purpose thereby reach to get rid of evils.
Function of the present invention cures mainly and is heat-clearing and toxic substances removing, QI and blood regulating, supporting vital QI and dispersing blood stasis, can suppress tumor neogenetic blood vessels generates, anticancer growth, reduction and elimination cancerous protuberance pain, and immune surveillance, the immunity of tumor are engulfed and immune clearance by improving the human body cell immunologic function, realize all kinds of cancers being carried out active treatment and prevention multi-facetedly, all kinds of early, middle and late phase tumors are all had therapeutical effect; Under low dosage, take for a long time, can play the effect of prophylaxis of tumours.The invention still further relates to said medicine or health product dosage form and preparation method, and the method for the scientific matching with practicality is provided, formulated the stable relevant discrimination method of this medicine or health product quality.
The specific embodiment
Prescription of the present invention has carried out preliminary treatment functional test and acute toxicity test, and preclinical basic research result shows that it can improve the animal subject immunologic function; Growth has stronger inhibitory action to mouse transplanted sarcoma (S180), and growth has the obvious suppression effect to rat liver cancer (HAC); The pure Chinese medicine extract of prescription of the present invention has the effect that suppresses tumor growth, and carries out acute, chronic toxicity test through ICS mice and SD rat, shows no obvious toxic and side effects; The extract of pure Chinese medicine has all shown comparatively obvious suppression effect to the growth of human leukaemia cell's strain K562, human lung carcinoma cell line SPR-A4, human stomach cancer cell line SGC-7901 and human hepatoma cell strain CA.Pharmacodynamic study is found: shown the drug effect that comparatively considerable inhibition tumor neogenetic blood vessels generates in the tumor neogenetic blood vessels model.
Preliminary research and development thing of the present invention is a capsule, after through preclinical study work such as acute and chronic toxicity test, pharmacology pharmacodynamics, tries out in the volunteer human body, has shown many positive therapeutic effects.
Relevant evidence can effectively suppress or cut off tumor vessel, thereby suppresses growth of tumor.After all kinds of cancer patients took 4～6 every day, quality of life made moderate progress, and spiritual appetite takes a turn for the better, and life quality obviously improves, and prolong life cycle, and part patient's cancerous protuberance all disappears; Cooperate the cancer patient operation or put, chemotherapy, take 2～4 every day, effectively improved put, the effect of chemotherapy; Patient is basically under the prerequisite by the doctor trained in Western medicine auxiliary treatment, can withstand that postoperative is put, the treatment of chemotherapy, and improves the routine blood test index, put, untoward reaction after the chemotherapy drops to minimum.
Take under 2 these dosage in every day and to take for a long time, can play the effect of prophylaxis of tumours.The pharmaceutical packing specification is: 60/bottle, 80/bottle, 120/bottle, and every net weight 0.4 gram.Instructions about how to take medicine: respectively obey 2～4 on an empty stomach every day sooner or later.
Claims (4)
1. a preparation that suppresses tumor-blood-vessel growth and cancerous cell, raise immunity is characterized in that forming by the component of following weight: Fructus Psoraleae 25～60 grams, Herba Epimedii 22～56 grams, Radix Angelicae Sinensis 26～70 grams, the Radix Astragali 30～70 grams, Radix Bupleuri 15～35 grams, Cordyceps 36～54 grams, Radix Cirsii Japonici 20～55 grams, Rhizoma Curcumae 26～50 grams, Radix Curcumae 28～99 grams, Rhizoma Imperatae 21～50 grams, Flos Carthami 18～80 grams, Cortex Phellodendri 30～50 grams, the Rhizoma Atractylodis Macrocephalae 30～85 grams, Radix Scutellariae 30～82 grams, Herba Violae 30～69 grams, Radix Glycyrrhizae 17～45 grams.
2. want 1 described preparation according to right, it is characterized in that component is by weight: Fructus Psoraleae 25 grams, Herba Epimedii 22 grams, Radix Angelicae Sinensis 26 grams, the Radix Astragali 30 grams, Radix Bupleuri 15 grams, Cordyceps 36 grams, Radix Cirsii Japonici 20 grams, Rhizoma Curcumae 26 grams, Radix Curcumae 28 grams, Rhizoma Imperatae 21 grams, Flos Carthami 18 grams, Cortex Phellodendri 30 grams, the Rhizoma Atractylodis Macrocephalae 30 grams, Radix Scutellariae 30 grams, Herba Violae 30 grams, Radix Glycyrrhizae 17 grams.
3. want 1 described preparation according to right, it is characterized in that: make capsule, tablet, syrup, oral liquid, granule or injection dosage form respectively with traditional handicraft or modern crafts.
4. want 1 described preparation according to right, it is characterized in that: make soft capsule respectively with traditional handicraft or modern crafts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100659292A CN101088555B (en) | 2007-06-04 | 2007-06-04 | Medicine preparation for inhibiting tumor angiogenesis and cancer cell and enhancing immunity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100659292A CN101088555B (en) | 2007-06-04 | 2007-06-04 | Medicine preparation for inhibiting tumor angiogenesis and cancer cell and enhancing immunity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101088555A CN101088555A (en) | 2007-12-19 |
| CN101088555B true CN101088555B (en) | 2011-05-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2007100659292A Expired - Fee Related CN101088555B (en) | 2007-06-04 | 2007-06-04 | Medicine preparation for inhibiting tumor angiogenesis and cancer cell and enhancing immunity |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101590105B (en) * | 2008-05-30 | 2012-10-31 | 财团法人工业技术研究院 | Chinese medicinal herb extract for inducing immune cells to generate interferon and activated TOLL-like receptors and preparation method thereof |
| CN113197969A (en) * | 2021-05-31 | 2021-08-03 | 北京洪山医药科技有限公司 | Tumor inhibition preparation and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1340346A (en) * | 2000-08-30 | 2002-03-20 | 周建禧 | Medical wine for replenishing vital essence and invigorating vital function and its preparing process |
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- 2007-06-04 CN CN2007100659292A patent/CN101088555B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1340346A (en) * | 2000-08-30 | 2002-03-20 | 周建禧 | Medical wine for replenishing vital essence and invigorating vital function and its preparing process |
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| CN101088555A (en) | 2007-12-19 |
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Granted publication date: 20110504 Termination date: 20200604 |