CN101085159A - Traditional Chinese medicine composition for treating nephrotic syndrome - Google Patents
Traditional Chinese medicine composition for treating nephrotic syndrome Download PDFInfo
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- CN101085159A CN101085159A CN 200710117921 CN200710117921A CN101085159A CN 101085159 A CN101085159 A CN 101085159A CN 200710117921 CN200710117921 CN 200710117921 CN 200710117921 A CN200710117921 A CN 200710117921A CN 101085159 A CN101085159 A CN 101085159A
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Abstract
The invention relates to a Chinese medicinal combination for treating nephrotic syndrome which is prepared from more than ten kinds of Chinese medicinal herbs including white atractylodes rhizome, eucommia bark, morinda root and bone fat.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of nephrotic syndrome, is that a kind of nephrotic syndrome for the treatment of is the Chinese medicine composition of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.
Background technology
(Nephrotic Syndrome NS) is proposed in 1932 by foreign scholar Hriction nephrotic syndrome.In order to summarize one group of card Hou Qun in the renal glomerular disease, it accounts for 70%～90% in child's renal glomerular disease, also account for 20%～30% in the adult.All have clinically a large amount of albuminuria (every day＞3.5g), hypoproteinemia (albumin＜30g/L), obviously edema, hyperlipemia (characteristic person such as serum cholesterol＞6.5mmol/L) can examine and is nephrotic syndrome.Nephrotic syndrome is at the clinical branch that constitutional and Secondary cases are arranged.Primary nephrotic syndrome (PNS) refers to by the sick causer of primary glomerular, adult's the most nephrotic syndrome of 2/3 and child is constitutional, pathological change is mainly the minute lesion type, and part is changes such as film, proliferative, film proliferative and focal nephrosclerosis.The patient of morbidity more than 45 years old, may be except must noting with malignant tumor, with Hodgkin, membranous nephropathy accompanies by solid tumors such as lung, breast, gastrointestinal etc. as minimal change nephropathy.The Secondary cases nephrotic syndrome is meant and is secondary to the whole body other diseases or by specificity cause of disease causer, as medicine mediation property nephrotic syndrome, the nephrotic syndrome that causes by allergy, poisoning, immunoreation, the nephrotic syndrome that causes by infection such as antibacterial, virus, parasites, nephrotic syndrome due to tumor and the heredity, nephrotic syndrome that metabolic disease caused such as systemic disease such as connective tissue, anaphylactoid purpura and diabetes, amyloidosis etc.Nephrotic syndrome 1/3 and the child 10% who is grown up can be by above-mentioned cause of disease secondary.Disease categories such as " edema " of nephrotic syndrome ownership Chinese medicine, " asthenia ".The clinical manifestation of primary disease is: a large amount of albuminuria (＞3.5g/24h), hypoproteinemia (albumin＜30g/L), obviously edema, hyperlipemia.The nephrotic syndrome course of disease is long, the relapse rate height, and simple western medicine treatment often can not obtain ideal effect, some intractable nephrotic syndromes especially, clinical treatment is often more thorny.And adopt the comprehensive method treatment nephrotic syndrome of Chinese and western medicine, and not only enlarged the treatment approach, and clinical confirmation obtained gratifying curative effect, be considered to comparatively ideal therapeutic scheme.
The traditional Chinese medical science is divided disease type Coryza Treated by Syndrome Differentiation such as retention of damp-heat in the interior, the wet dipping of water, edema due to YANG-insufficiency, stagnation of dampness due to deficiency of the spleen, edema due to wind pathogen Xiang Bo clinically, obtains very good effect.Therefore invent a kind of not only safety but also effective Chinese medicine preparation, be significant.
Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of nephrotic syndrome.Have determined curative effect, safe ready, have no side effect, cheap characteristics.
The present invention is made by the following weight proportion raw material:
1.5～6 parts of 1.5～6 parts of Radix Morindae Officinaliss of 1.5～6 parts of Cortexs Eucommiae of the Rhizoma Atractylodis Macrocephalae
1.0～4 parts of 1.0～4 parts of Radix Rehmanniae Preparata of 1.0～4 parts of Radix Astragali of Radix Codonopsis
1.0～4 parts of 1.0～4 parts of Herba Leonuris of 1.0～4 parts of Fructus Psoraleaes of Rhizoma Alismatis
0.1～2 part of 0.1～2 portion of Fructus Rubi of 0.1～2 part of Radix Angelicae Sinensis of Rhizoma Dioscoreae.
The weight proportion of each raw material of optimization formula of the present invention is:
2.5～3.5 parts of 2.5～3.5 parts of Radix Morindae Officinaliss of 2.5～3.5 parts of Cortexs Eucommiae of the Rhizoma Atractylodis Macrocephalae
1.5～2.5 parts of 1.5～2.5 parts of Radix Rehmanniae Preparata of 1.5～2.5 parts of Radix Astragali of Radix Codonopsis
1.5～2.5 parts of 1.5～2.5 parts of Herba Leonuris of 1.5～2.5 parts of Fructus Psoraleaes of Rhizoma Alismatis
0.5～1.5 part of 0.5～1.5 portion of Fructus Rubi of 0.5～1.5 part of Radix Angelicae Sinensis of Rhizoma Dioscoreae.
The weight proportion of each raw material of optimum formula of the present invention is:
3 parts of 3 parts of Radix Morindae Officinaliss of 3 parts of Cortexs Eucommiae of the Rhizoma Atractylodis Macrocephalae
2 parts of 2 parts of Radix Rehmanniae Preparata of 2 parts of Radix Astragali of Radix Codonopsis
2 parts of 2 parts of Herba Leonuris of 2 parts of Fructus Psoraleaes of Rhizoma Alismatis
1 part of 1 portion of Fructus Rubi of 1 part of Radix Angelicae Sinensis of Rhizoma Dioscoreae.
Drug action mechanism among the present invention is as follows:
Rhizoma Atractylodis Macrocephalae hardship, sweet, temperature.Return spleen, stomach warp.Has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.Can treat the weak of deficiency-weakness of spleen-QI, lack of appetite abdominal distention is had loose bowels, constipation, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement etc.(the 945th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Sweet, the little suffering of the Cortex Eucommiae property of medicine, temperature.Return liver, kidney channel.Has invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect.Can treat soreness of waist and knee joint, sexual impotence, frequent micturition, dribbling urination, rheumatic arthralgia, frequent fetal movement, habitual abortion etc.(the 1514th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Radix Morindae Officinalis property of medicine suffering, sweet, tepor.Return liver, kidney channel.Has reinforcing the kidney and supporting YANG, bone and muscle strengthening, the effect of expelling wind and removing dampness.Can treat impotence due to deficiency of the kidney, the seminal emission premature ejaculation, few abdomen cold type of pain, incontinence of urine, cold womb is infertile, anemofrigid-damp arthralgia, soreness of the waist and knees, rheumatism beriberi etc.(the 709th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Radix Codonopsis property of medicine is sweet, and is flat.Return spleen, lung meridian.Has strengthening the spleen and tonifying the lung, the effect of supplementing QI for promoting the production of body fluid.Can treat weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung is breathed with cough, the spontaneous perspiration of breathing hard, deficiency of both QI and blood etc.(the 2579th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Radix Astragali property of medicine is sweet, warm.Return lung, spleen channel.Has benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, the effect of promoting pus discharge and tissue regeneration strengthening.Can treat the card of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, the cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle is difficult bursts or bursts for a long time and do not hold back etc.(the 2813rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Radix Rehmanniae Preparata sweet in the mouth, slightly warm in nature.Have nourishing YIN and supplementing blood, beneficial essence is filled out the effect of marrow.Can treat soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair, anemia etc.(the 197th page of chief editor such as the firm Xiao Ying of party " Chinese medicine and health food development and exploitation " People's Health Publisher).
The Rhizoma Alismatis property of medicine is sweet, light, and is cold.Return kidney, urinary bladder channel.Have promoting diuresis to eliminate damp pathogen, treating stranguria effect expels the heat-evil.Can treat dysuria, the puckery pain of pyretic stranguria, the edema distension is had loose bowels, dizziness due to fluid-retention, seminal emission etc.(the 2067th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Fructus Psoraleae property of medicine suffering, hardship, temperature.Return kidney, spleen channel.Has reinforcing the kidney and supporting YANG, controlling nocturnal emission with astringent drugs reducing urination, warm spleen antidiarrheal effect.Can treat the deficiency and coldness lumbago, sexual impotence spermatorrhea, the enuresis, frequent micturition, chronic diarrhea, dyspnea due to deficiency, vitiligo, alopecia areata, psoriasis etc.(the 1647th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Herba Leonuri property of medicine suffering, hardship are slightly cold.Return liver, kidney, pericardium channel.Has promoting blood flow to regulate menstruation, inducing diuresis to remove edema, the effect of heat-clearing and toxic substances removing.Can treat menoxenia, amenorrhea, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, traumatic injury, dysuria, edema, carbuncle skin infection etc.(the 2697th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Rhizoma Dioscoreae property of medicine is sweet, flat.Return spleen, lung, kidney channel.Have spleen reinforcing, support lung, reinforce the kidney, the effect that benefit is smart.Can treat diarrhea due to hypofunction of the spleen, the lack of appetite edema, cough and asthma due to lung deficiency is quenched one's thirst, seminal emission, leukorrhagia, the frequent micturition of suffering from a deficiency of the kidney.Carbuncle is controlled in external, scrofula etc.(the 218th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Radix Angelicae Sinensis property of medicine is sweet, hot, bitter, temperature.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of moisturizing laxation.Can treat all cards of blood deficiency, menoxenia, amenorrhea, dysmenorrhea ， mass in the abdomen knot is poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, the dryness of the intestine dyschezia, heavy after the bloody dysentery, ulcer sores, injury from falling down etc.(the 1210th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Fructus Rubi property of medicine is sweet, sour, tepor.Return liver, kidney channel.Has the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, the effect that makes eye bright.Can treat impotence and premature ejaculation, emission and spermatorrhea, cold womb is infertile, and leukorrhagia is rare clearly, and the frequent micturition incontinence of urine is visual dim, early whitening of beard and hair etc.(the 3813rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with the Rhizoma Atractylodis Macrocephalae, the Cortex Eucommiae and Radix Morindae Officinalis; With Radix Codonopsis, Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Alismatis, Fructus Psoraleae and Herba Leonuri is ministerial drug; With Rhizoma Dioscoreae, Radix Angelicae Sinensis and Fructus Rubi is adjuvant.All medicines are harmonious, and are total to the tool warming and recuperating the spleen and kidney, the effect of benefiting QI and nourishing blood.The treatment nephrotic syndrome has determined curative effect, has no side effect taking convenience, cheap characteristics.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of Pharmacopoeia of People's Republic of China, utilizes the comprehensive function treatment nephrotic syndrome of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.
3, the present invention not only can effectively treat nephrotic syndrome, and the prevention of nephrotic syndrome is also had good effect, and the treatment nephrotic syndrome has determined curative effect, has no side effect taking convenience, cheap characteristics.
For showing medicine of the present invention, as follows through clinical test results to treatment management of Idiopathic Nephrotic Syndrome in Children effect; Treatment nephrotic syndrome patient 14 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Three months is a course of treatment, take continuously three the course of treatment observe the curative effect.6 examples of fully recovering account for 42.86%, and 6 examples that take a turn for the better account for 42.86%, and invalid 2 examples account for 14.29%, and total effective rate reaches 85.72%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
The embodiment decoction takes by weighing raw material by following weight:
3 parts of 3 parts of Radix Morindae Officinaliss of 3 parts of Cortexs Eucommiae of the Rhizoma Atractylodis Macrocephalae
2 parts of 2 parts of Radix Rehmanniae Preparata of 2 parts of Radix Astragali of Radix Codonopsis
2 parts of 2 parts of Herba Leonuris of 2 parts of Fructus Psoraleaes of Rhizoma Alismatis
1 part of 1 portion of Fructus Rubi of 1 part of Radix Angelicae Sinensis of Rhizoma Dioscoreae.
Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment nephrotic syndrome that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.Three months is a course of treatment.
Claims (3)
1, a kind of Chinese medicine composition for the treatment of nephrotic syndrome is characterized in that it is made by the following weight proportion raw material:
1.5～6 parts of 1.5～6 parts of Radix Morindae Officinaliss of 1.5～6 parts of Cortexs Eucommiae of the Rhizoma Atractylodis Macrocephalae
1.0～4 parts of 1.0～4 parts of Radix Rehmanniae Preparata of 1.0～4 parts of Radix Astragali of Radix Codonopsis
1.0～4 parts of 1.0～4 parts of Herba Leonuris of 1.0～4 parts of Fructus Psoraleaes of Rhizoma Alismatis
0.1～2 part of 0.1～2 portion of Fructus Rubi of 0.1～2 part of Radix Angelicae Sinensis of Rhizoma Dioscoreae.
2, a kind of Chinese medicine composition for the treatment of nephrotic syndrome according to claim 1, wherein the weight proportion of each raw material is:
2.5～3.5 parts of 2.5～3.5 parts of Radix Morindae Officinaliss of 2.5～3.5 parts of Cortexs Eucommiae of the Rhizoma Atractylodis Macrocephalae
1.5～2.5 parts of 1.5～2.5 parts of Radix Rehmanniae Preparata of 1.5～2.5 parts of Radix Astragali of Radix Codonopsis
1.5～2.5 parts of 1.5～2.5 parts of Herba Leonuris of 1.5～2.5 parts of Fructus Psoraleaes of Rhizoma Alismatis
0.5～1.5 part of 0.5～1.5 portion of Fructus Rubi of 0.5～1.5 part of Radix Angelicae Sinensis of Rhizoma Dioscoreae.
3, a kind of Chinese medicine composition for the treatment of nephrotic syndrome according to claim 1, wherein the weight proportion of each raw material is:
3 parts of 3 parts of Radix Morindae Officinaliss of 3 parts of Cortexs Eucommiae of the Rhizoma Atractylodis Macrocephalae
2 parts of 2 parts of Radix Rehmanniae Preparata of 2 parts of Radix Astragali of Radix Codonopsis
2 parts of 2 parts of Herba Leonuris of 2 parts of Fructus Psoraleaes of Rhizoma Alismatis
1 part of 1 portion of Fructus Rubi of 1 part of Radix Angelicae Sinensis of Rhizoma Dioscoreae.
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| CN 200710117921 CN101085159A (en) | 2007-06-26 | 2007-06-26 | Traditional Chinese medicine composition for treating nephrotic syndrome |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688414A (en) * | 2012-06-25 | 2012-09-26 | 许梅 | Traditional Chinese medicine composition for treating uremia by being matched with hematodialysis, preparation method and application thereof |
| CN103212031A (en) * | 2013-04-24 | 2013-07-24 | 刘冰甜 | Traditional Chinese medicine composition for treating primary nephrotic syndrome and preparation method thereof |
| CN104258204A (en) * | 2014-10-23 | 2015-01-07 | 石家庄肾病医院 | Traditional Chinese medicine composition and application thereof to preparation of nephrotic syndrome treating drug |
| CN105288041A (en) * | 2015-10-29 | 2016-02-03 | 李连庆 | Traditional Chinese medicine preparation for preventing and treating nephrotic syndrome and preparation method thereof |
| CN106822712A (en) * | 2017-03-01 | 2017-06-13 | 贵州都匀市剑江药业有限公司 | Chinese medicine composition and its preparation method and application for treating pyelonephritis |
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2007
- 2007-06-26 CN CN 200710117921 patent/CN101085159A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688414A (en) * | 2012-06-25 | 2012-09-26 | 许梅 | Traditional Chinese medicine composition for treating uremia by being matched with hematodialysis, preparation method and application thereof |
| CN102688414B (en) * | 2012-06-25 | 2013-10-30 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine composition for treating uremia by being matched with hematodialysis, preparation method and application thereof |
| CN103212031A (en) * | 2013-04-24 | 2013-07-24 | 刘冰甜 | Traditional Chinese medicine composition for treating primary nephrotic syndrome and preparation method thereof |
| CN103212031B (en) * | 2013-04-24 | 2014-12-17 | 王喜功 | Traditional Chinese medicine composition for treating primary nephrotic syndrome and preparation method thereof |
| CN104258204A (en) * | 2014-10-23 | 2015-01-07 | 石家庄肾病医院 | Traditional Chinese medicine composition and application thereof to preparation of nephrotic syndrome treating drug |
| CN104258204B (en) * | 2014-10-23 | 2017-08-25 | 石家庄肾病医院股份有限公司 | A kind of Chinese medicine composition and its application in treatment nephrotic syndrome medicine is prepared |
| CN105288041A (en) * | 2015-10-29 | 2016-02-03 | 李连庆 | Traditional Chinese medicine preparation for preventing and treating nephrotic syndrome and preparation method thereof |
| CN106822712A (en) * | 2017-03-01 | 2017-06-13 | 贵州都匀市剑江药业有限公司 | Chinese medicine composition and its preparation method and application for treating pyelonephritis |
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Open date: 20071212 |