CN101068826B - 有效抑制hif-1a表达的lna寡核苷酸 - Google Patents
有效抑制hif-1a表达的lna寡核苷酸 Download PDFInfo
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- CN101068826B CN101068826B CN2005800412161A CN200580041216A CN101068826B CN 101068826 B CN101068826 B CN 101068826B CN 2005800412161 A CN2005800412161 A CN 2005800412161A CN 200580041216 A CN200580041216 A CN 200580041216A CN 101068826 B CN101068826 B CN 101068826B
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Abstract
Description
SEQ ID NO.1 | 5′-TsGsGscsasasgscsastscscsTsGsTsa-3′ |
SEQ ID NO.2 | 5′-GsTsTsascstsgscscststscsTsTsAsc-3′ |
SEQ ID NO.3 | 5′-(T x)GxGxcsasasgscsastscscsTxGx(T)-3′ |
SEQ ID NO.4 | 5′-(G x)TxTxascstsgscscststscsTxTx(A)-3′ |
SEQ ID NO.5 | 5′-TGGcsasasgscsastscscsTGTa-3′ |
SEQ ID NO.6 | 5′-TGGcaagcatccTGTa-3′ |
SEQ ID NO.7 | FAM-TsGsGscsasasgscsastscscsTsGsTsa-3′ |
SEQ ID NO.8 | 5′-CsGsTscsasgstsastsgscsgsAsAsTsc-3′ |
SEQ ID NO.9 | 5′-TsGsGscsasasascsastscscsTsGsTsa-3′ |
SEQ ID NO.10 | 5′-TsGsAscsasasgscsastscscsAsGsTsa-3′ |
SEQ ID NO.11 | 5′-TGGTgsasgsgscstsgstsCCGA-3′ |
SEQ ID NO.12 | 5′-TTGCgsgsascstscsgsgsATGG-3′ |
SEQ ID NO.13 | 5′-tsgsgscsasasgscsastscscstsgstsa-3′ |
SEQ ID NO.14 | 5′-TsTs mCscstsastsgscstsgstsAsTs mCsc-3′ |
SEQ ID NO.15 | 5′-TsGsGscsasasgscsastscscsTsGsT-3′ |
SEQ ID NO.16 | 5′-GsGscsasasgscsastscscsTsGst-3′ |
SEQ ID NO.17 | 5′-GsTsTsascstsgscscststscsTsTsAs-3′ |
SEQ ID NO.18 | 5′-TsTsascstsgscscststscsTsTsa-3′ |
SEQ ID NO.19 | 5′-TsGsGscsasasgscsastscscsTsGst-3′ |
SEQ ID NO.20 | FAM-CsGsTscsasgstsastsgscsgsAsAsTsc-3′ |
序列\Tm | DNA | RNA |
SEQ ID NO.1TsGsGscsasasgscsastscscsTsGsTsa | 64.2℃ | 68.4℃ |
Claims (13)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62656304P | 2004-11-09 | 2004-11-09 | |
US60/626,563 | 2004-11-09 | ||
US64718605P | 2005-01-25 | 2005-01-25 | |
US60/647,186 | 2005-01-25 | ||
US69972105P | 2005-07-15 | 2005-07-15 | |
US60/699,721 | 2005-07-15 | ||
US72462105P | 2005-10-07 | 2005-10-07 | |
US60/724,621 | 2005-10-07 | ||
PCT/DK2005/000721 WO2006050734A2 (en) | 2004-11-09 | 2005-11-09 | Potent lna oligonucleotides for the inhibition of hif-1a expression |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101068826A CN101068826A (zh) | 2007-11-07 |
CN101068826B true CN101068826B (zh) | 2011-11-16 |
Family
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Application Number | Title | Priority Date | Filing Date |
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CN2005800412161A Expired - Fee Related CN101068826B (zh) | 2004-11-09 | 2005-11-09 | 有效抑制hif-1a表达的lna寡核苷酸 |
Country Status (4)
Country | Link |
---|---|
CN (1) | CN101068826B (zh) |
ES (1) | ES2348247T3 (zh) |
UA (1) | UA93188C2 (zh) |
ZA (1) | ZA200704253B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104586794A (zh) * | 2014-12-25 | 2015-05-06 | 海南卫康制药(潜山)有限公司 | 一种氨鲁米特组合物冻干片及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003085110A2 (en) * | 2002-04-05 | 2003-10-16 | Santaris Pharma A/S | Oligomeric compounds for the modulation hif-1alpha expression |
-
2005
- 2005-11-09 UA UAA200706383A patent/UA93188C2/ru unknown
- 2005-11-09 CN CN2005800412161A patent/CN101068826B/zh not_active Expired - Fee Related
- 2005-11-09 ES ES05800760T patent/ES2348247T3/es active Active
- 2005-11-09 ZA ZA200704253A patent/ZA200704253B/xx unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003085110A2 (en) * | 2002-04-05 | 2003-10-16 | Santaris Pharma A/S | Oligomeric compounds for the modulation hif-1alpha expression |
Also Published As
Publication number | Publication date |
---|---|
ZA200704253B (en) | 2008-09-25 |
UA93188C2 (ru) | 2011-01-25 |
ES2348247T3 (es) | 2010-12-02 |
CN101068826A (zh) | 2007-11-07 |
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