CN101068500A

CN101068500A - Graphical user interface for tissue biopsy system

Info

Publication number: CN101068500A
Application number: CN 200580040941
Authority: CN
Inventors: 德里克·道; 弗兰克·洛; 保罗·卢博克; 理查德·L·奎克; 马丁·沙巴兹
Original assignee: SenoRx Inc
Current assignee: SenoRx Inc
Priority date: 2004-11-29
Filing date: 2005-11-28
Publication date: 2007-11-07

Abstract

A graphical user interface is disclosed for a tissue biopsy system having a tissue cutting member adapted for cutting one or more tissue specimens from tissue at a target site within a patient. The graphical user interface includes a first GUI area representing a first region of the target site from which the tissue cutting member has separated one or more tissue specimens. The graphical user interface further includes a second GUI area, visually distinguishable from the first GUI area, representing a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site.

Description

The graphic user interface that is used for tissue biopsy system

Technical field

The present invention relates generally to and organize removal device (such as tissue biopsy device).More specifically, the present invention relates to the graphic user interface (GUI) that is used in combination with this tissue removal device.

Background technology

When diagnosing and handling some medical conditions (such as the latent carcinoma tumor), biopsy is carried out in expectation usually, and in this biopsy, the specimen of taking off suspect tissue is to carry out the pathology examination and to analyze.In many cases, suspect tissue is arranged in subcutaneous position, in human breast.Minimize for the surgical operation that enters in the patient body is invaded, expectation can be inserted into less instrument in patient's body also to extract the tissue examination specimen therefrom near target site.

Electrosurgical techniques has been used in the multiple biopsy procedures.In electrosurgery, typically, high-frequency electrical energy puts on patient tissue by active electrode, and by making circuit complete with the contacted refurn electrode of patient tissue.Excise near the active electrode tissue effectively from electric energy this active electrode and that flow through tissue, in tissue, form opening, thereby make instrument be inserted in patient's body.Refurn electrode can be arranged on the outside of patient body or can be included in the device itself.Typically, refurn electrode invests some place of on one's body certain of patient, and this o'clock is away from first or active electrode and organize contacted position.

Traditionally, when electrosurgery tissue examination instrument is inserted in patient's body, be difficult for seeing its cut end from the outside.This makes the surgeon be difficult to find the residing position of electrosurgery tissue examination instrument in the tissue examination operation.Therefore, expectation has a kind of display device, visually is illustrated in the tissue examination operation electrosurgery tissue examination instrument with respect to the position of patient body.

Summary of the invention

The present invention relates to be used for the graphic user interface of tissue biopsy system, this tissue biopsy system has the cutting member of organizing that is suitable for cutting one or more tissue specimens from the tissue of patient's body target site.

In one embodiment, graphic user interface comprises GUI zone and the 2nd GUI zone at least.The first area of the one GUI region representation target site by this first area, organizes cutting member to separate one or more tissue specimens.Visually the 2nd GUI region representation second area that separates with a GUI area region by this second area, organizes cutting member can separate one or more additional tissue specimens from the tissue of target site.

Description of drawings

Fig. 1 is the exploded view that embodies the elongated tissue biopsy system of feature of the present invention.

Fig. 2 is the perspective view embodiment illustrated in fig. 1 that is in the confined state, wherein is not used in the casing cover of probe member.

Fig. 3 is the side view of tissue biopsy device shown in Figure 2.

Fig. 4 A is the longitdinal cross-section diagram of the probe shown in Figure 3 of 4-4 intercepting along the line, wherein, organizes cutting member to be in the retracted position.

Fig. 4 B is the longitdinal cross-section diagram of the probe shown in Figure 3 of 4-4 along the line intercepting, wherein, organizes cutting member to be in forward or in the closed position.

Fig. 5 is the view in transverse section of probe shown in Fig. 4 B of 5-5 along the line intercepting.

Fig. 6 is the perspective view of the downside of probe shown in Figure 1.

Fig. 7 is the enlarged perspective of driver element far-end shown in Figure 1.

Fig. 8 is the enlarged perspective of the far-end of probe case, and this shell shows the sign element, and this sign element illustrates the orientation in the hole in the tubular portion of tissue biopsy device.

Fig. 9 is assembling and the perspective view that is installed in the tissue biopsy system shown in Figure 1 on orientation (stereotactic) framework.

Figure 10 is the perspective view of the downside of driver shown in Figure 1.

Figure 11 is the front view that has the token-passing device of horn-like guider on the far-end of axle, and this guider helps the distal tip of leader label transporter to enter in the near-end inside of tissue cutter.

Figure 12 is provided in a side of the far-end of the token-passing device in tissue collecting's parts shown in Figure 1 and the longitdinal cross-section diagram of horn-like guider.

Figure 13 is the longitdinal cross-section diagram of the near-end of token-passing device, and wherein, horn-like guider is positioned at the proximal end of axle, and axle is arranged in the inner chamber of tissue cutter.

Figure 14 shows the screen that provides about the information of tissue biopsy system operation.

Figure 15 A to 15E shows a plurality of replaceable circular graphical user interfaces, each all has GUI zone and the 2nd GUI zone, such various piece of their expression patient body target site maybe can be isolated one or more tissue specimens from tissue from tissue from described part.

Figure 16 A to 16E shows a plurality of replaceable polygonal shape user interfaces, each all has GUI zone and the 2nd GUI zone, such various piece of their expression patient body target site maybe can be isolated one or more tissue specimens from tissue from tissue from described part.

Figure 17 A to 17E shows a plurality of replaceable circular graphical user interfaces, each all has first, second or the 3rd GUI zone, such various piece of their expression patient body target site has been separated from described part or is separablely gone out one or more tissue specimens or organize cutting member disposed therein.

Figure 18 A to 18E shows a plurality of replaceable polygonal shape user interfaces, each all has first, second or the 3rd GUI zone, such various piece of their expression patient body target site has been separated from described part or is separablely gone out one or more tissue specimens or organize cutting member disposed therein.

The specific embodiment

Fig. 1-3 shows the tissue biopsy system 10 that embodies feature of the present invention, and this tissue biopsy system comprises disposable probe parts 11, drive unit 12 and specimen trap 13.

Probe member 11 generally includes the elongated distal shaft 14 with tubular portion or sleeve pipe 15, has the tissue that is positioned on its far-end and thrusts most advanced and sophisticated 16 and the open receiver hole 17 of organizing.Probe member 11 also comprises the probe case 18 with casing cover 19, and this casing cover is configured to and drive unit 12 cooperatively interact (interfit).Tissue cutter 20 slidably is located in the probe and has distal cut surface 21, and this distal cut surface cuts off passes the tissue of organizing receiver hole 17.

In Fig. 4 A and 4B, further show the details of probe member 11.Probe case 18 has mechanical system, and tubular portion 15 rotations that this mechanical system is used to make shell and is fixed thereon are organized the position, angle of receiver hole 17 with control, and are used for making that the tissue cutter 20 that slidably are located in the probe member 11 move.

The mechanical system of drive unit 12 has first driven wheel 22, and this first driven wheel is configured to engages probe gear 23 and rotates probe case 18, thereby is adjusted in the orientation in the hole 17 in the utmost point far-end of tubular portion 15.Probe gear 23 is anchored on the connector body 24 of rotation by binding agent 25.The utmost point near-end of tubular portion 15 is anchored on the connector body 24 of rotation by binding agent 26.End cap 27 remains on connector body 24 in the probe case 18.The rotation of probe gear 23 makes connector body 24 and appended tubular portion 15 rotate.Preferably, this rotation is controlled, thereby tubular portion 15 rotates around longitudinal axis 28 with discontinuous step, with the angle direction of adjustment hole 17 about longitudinal axis.Preferably, these discontinuous directions can be provided in the mode of 30 ° of increments, and this is by the arrow 29 clear indications of probe case shown in Figure 8 18 far-ends.

Second driven wheel 30 is configured to vertically drive tissue cutter 20.Driven wheel 30 engages probe gear 31, the cutter screw 33 that this probe gear drives cutter traverse nut 32 and is threadedly connected to this cutter traverse nut.The far-end of cutter screw 33 is equipped with recess 34, and this recess holds the flank 35 of cutter shuttle 36.Cutter shuttle 36 is fixed in tissue cutter 20 by binding agent 37.Probe gear 31 is fixed in cutter traverse nut 32 by binding agent 38.The position to axial with respect to cutter traverse nut 32 of cutter screw 33 is regulated in the rotation of probe gear 31, and wherein cutter traverse nut 32 is fixed in cutter shuttle 36.Because cutter screw 33 moves, moving of cutter shuttle 36 followed in vertically moving of tissue cutter 20.By before cutting, regulating the initial lengthwise position of far-end in the hole of tissue cutter 20, organize the length of receiver hole 17 and the specimen length that therefore causes can be controlled.

The 3rd driven wheel 40 is configured to, and makes this cutter rotate or vibrations in tissue cutter 20 when longitudinally axle 28 moves, to help the cutting action on the cutting surface 21 on the cutter far-end.The 3rd driven wheel 40 engages probe gear 41, this probe gear is fixed in cutter oscillation shaft 42 by binding agent 43.According to the rotation of required tissue cutter, probe gear 41 can be rotated continuously about longitudinal axis 28 pitchings or along single direction around longitudinal axis, or both have both.

Bias valve assembly 44 is located in the far-end of probe case 18, so that guarantee sealing when producing vacuum in the inside 45 in tissue cutter 20, provides atmosphere blow vent 46 simultaneously between the outer surface 48 of the inner surface 47 of tubular portion 15 and tissue cutter 20.Valve module 44 comprises spring 49, valve body 50 and valve collar 51, and this valve collar 51 is fixed in the near-end of tubular portion 15 by binding agent 52.The near-end of valve spring 49 is put and is leaned against in the shoulder portion 53, and this shoulder portion is located at the outside of valve body 50.Biased cutter shaft seal 54 is sliding engaged to the outside 48 of tissue cutter 20.

Tissue specimen catcher 13 is fixed in the near-end of probe member 11 shells, and have inner 55, this inside is communicated with inner chamber 56 fluids of extension in the tissue cutter 20, and having a removable diapire (proximal wall) 57 of specimen receiving barrel 58, this removable diapire permits coming in and going out inner 55 and near any tissue specimen that has been received in wherein.In inner 55, produce vacuum with by inner chamber 45 with draw tissue specimens in inner 55.Tube-like piece 59 has the far-end that is communicated with inside 55 fluids of tissue specimen catcher 13, and has the near-end (not shown) that is configured to be connected to vacuum source.In tube-like piece 59, use vacuum and help tissue is pulled in the inside 17 of tubular portion 15, and the tissue specimen that downcuts is transported to specimen receiving barrel 58 by the inner chamber 45 of tissue cutter 20.

Driver 12 has the shell 60 that has recessed surface 61, top, and recessed surface, this top is configured for the lower surface 62 that receives probe case 18.The driven

wheel

22,30 and 40 that expose three parts is located on the near-end of driver 12, and they are configured to engages

probe gear

23,31 and 41 respectively.Driver 12 is equipped with the drive motors (not shown) of three independent operations, and these drive motors drive driven

wheel

22,30 and 40.Independently the operation that is connected to control module and drive motors of drive motors (not shown) is by this control module control (such as described in the common pending application series number of submitting on May 17th, 2,004 10/847,699).Control module control motor, this motor moves each driven

wheel

22,30 and 40.Gear 23 in gear 22 engages probe 11 is with the rotation of control probe case 18 and position and the orientation of organizing receiver hole 17.Driven wheel 30 engages probe gear 31 are with the control lengthwise position of tissue cutter 20 and this tissue cutter moving of axle 28 longitudinally.Driven wheel 40 engages probe gear 41 are with vibrations or the rotation of control tissue cutter 20 about longitudinal axis 28.

As shown in Figure 7, the switch 68 that the front surface of drive unit 12 is equipped with

light source

66,67 and can manually boots, this switch 68 are used to start light source and make doctor and other operator more clearly observe patient's operative site.Also can use other hand switch, for example the foot starting switch.Replacedly, be installed on the driver 12 or under other situation such as when energized the time, light source can be opened automatically when probe member 11.Drive unit 12 can have the set of cells that is used for

light source

66,67.

Thrust distal tip 16 and can have multiple tip shapes.In the common unsettled provisional application series number 60/532,277 of December in 2003 submission on the 23rd, particularly suitable distal tip shape has been described.Replacedly, distal tip can be equipped with arcuate RF electrode, and such as United States Patent (USP) the 6th, 261, disclosed in No. 241 and the United States Patent (USP) the 6th, 471,700, two mentioned patents all transfer this assignee.

Independent driver parts 12 make that the whole probe unit is disposable.The motion of the motion of organizing cutting member 20 that the driven wheel control of drive unit 12 is used to cut and the tubular portion 15 that is used for directional hole 17.Other device (not shown) can be probe unit mechanical energy and electric energy, vacuum and control is provided.Disclose the example of removable snap-type probe unit in people's such as Burbank the U.S. Patent application 10/179,933 that is entitled as " Apparatus and Methods for Accessing a Body Site ", its full content is incorporated herein by reference.Those skilled in the art can be easily to such as the WO 02/069808 that transfers this assignee (the common unsettled U. S. application series number 09/707 that itself and on November 6th, 2000 submit to, 022 and the U. S. application series number 09/864 submitted to May 23 calendar year 2001,021 is corresponding) the middle driver element of describing is made amendment, so that it adapts to moving of cutting member 20.

Tissue cutter 20 be in forward or closed position (Fig. 4 B) in situation under, the far-end of probe member 11 advances in patient's body, is positioned at up to the hole 17 of tubular portion 15 to take out place, tissue specimen desired position.Then tissue cutter 20 nearside ground (proximally) are retracted into aperture position to open hole 17.This length that can be used for control hole of recalling of tissue cutter has this hole to control the length of the specimen of being downcut.In the inside 45 of tissue cutter 20, apply vacuum so that be drawn in the inner chamber of tubular portion 15 by the tissue of hole 17 with the position.Then, this tissue cutter 20 is driven in the rotation of far-end by probe gear 30, and rotate or shake, thereby from the supporting tissue of target site, downcut the tissue that sucks (aspirate) by tissue cutting surface 21 by the driven wheel 40 that engages with probe gear 41.The inner chamber 45 that vacuum in tissue cutter 20 inside makes tissue specimen to be inhaled into to pass tissue cutter 20 and enter into the tube 58 of the specimen trap 13 shown in Fig. 2.Normal pressure or the uniform environment far away apart from tissue specimen can help to organize the inside 45 of passing tissue cutter 20.Another tissue specimen can make tubular portion 15 rotate by the driven wheel 22 that engages with probe gear 23 in one or more steps, thereby repeat in the same manner to obtain another tissue specimen, and need not traveling probe parts 11 if desired.Typically,, obtain second tissue specimen, obtain the 3rd tissue specimen in 9 o-clock position, and obtain the 4th tissue specimen in 6 o-clock position in 3 o-clock position at hole 17 acquisitions first tissue specimen of 12 o-clock position by probe 11.The position of the second and the 3rd specimen can be put upside down.The position in hole 17 can be by marker arrow 29 indications at end cap 27 places, so that doctor or other operator can judge easily that hole 17 is in the intravital orientation of patient.

Tissue biopsy system 10 is hand-holdable to be used for some biopsy procedures, and perhaps this system can be installed on the directed erecting bed 80, as shown in Figure 9.Slide block (shoe) 81 is slidably mounted on the track 82 of Fei Xier (Fisher) platform.Installed part 83 is anchored on slide block 81 by the threaded post (not shown) that is fixed in thumb wheel 84.As shown in Figure 10, the basal surface 85 of drive unit 12 is configured to consistent with the upper surface of installed part 83 at least in part.The sampling switch 86 and the vacuum switch 87 that lay respectively on the drive unit 12 are started by optional sampling starting element 88 on the installed part 83 and vacuum starting element 89.Replacedly, can start sampling and vacuum by foot switch.As shown in Figure 10, drive unit has operation board 90, when rotating this operation board, this operation board is opened screwed hole 91 and dowel hole 92,93, screwed hole 91 is used to receive the threaded post (not shown) that is fixed in thumb wheel 84, the complementary post (not shown) that dowel hole 92,93 receives in the installed part 83.

Aforesaid, the inner chamber 45 that the tissue specimen that normal pressure or uniform environment will help to downcut passes tissue cutter 20 enters the tube 58 of specimen trap 13.As shown in Figure 4A and 4B, venting valve can provide ambient pressure in the tissue specimen back of cutter inside 45 from the inside of tubular portion 15.Finish under the situation of downcutting specimen from tissue site, when tissue cutter 20 was in forward the position, valve body 50 was opened so that ventilate.Yet, when tissue cutter 20 nearsides when being pulled, valve spring 49 back into the closed position with valve body 50.Though showing tissue cutter 20 has perpendicular to the tissue of longitudinal axis 28 cutting surface 21, but this tissue cutting surface also can be with longitudinal axis angled or even be parallel to longitudinal axis, described in the common pending application series number of submitting on August 15th, 2,003 10/642,406.

The far-end blade 21 of tissue cutter 20 can be positioned at first and be close to hole 17, so that tissue receiving, perhaps this far-end blade 21 can be arranged in the hole 17 at first so that the length of control specimen so that full hole to be provided.Before 21 complete cross-section holes 17, bevelled cutting surface, the cutting action of tissue cutter 20 is preferably successive, is downcut fully from the supporting tissue at biopsy position by the tissue that the hole sucks guaranteeing.Vacuum can be applied so that the tissue specimen that downcuts sucked the tube that passes the inner chamber of tissue cutter 20 and enter into the specimen trap of tissue biopsy device proximal end.Far-end at tubular portion can provide normal pressure or make it can obtain environmental condition, with auxiliary specimen transfer.

Be removed and after wherein specimen is removed, wish usually to carry one or more labellings at the removable wall 57 of specimen receiving barrel 58 to the target site that specimen therefrom removes.In common pending application series number of submitting on January 7th, 2,004 10/753,694 and the common pending application series number of submitting on May 23rd, 2,003 10/444,770 such marker delivery device has been shown.Yet, the far-end of these marker delivery device very little and they may be difficult to be inserted in the near-end of tissue cutter 20, the near-end of tissue cutter 20 is more bigger to hold the labelling conveying axis.

Figure 11 shows marker delivery device 100, and particularly, this marker delivery device is suitable for promoting the far-end of axle 101 to enter into the inner chamber 45 of tissue cutter 20 and advances at this inner chamber.As indicated, before tissue biopsy system 10 is removed from the patient, one or more labellings are sprayed (eiect) in the inner chamber 45 of tissue cutter 20 on one's body by the hole in the tubular portion 15 17.As shown in Figure 12, be inserted into for the minor diameter distal tip 101 that helps marker delivery device 100 in the bigger inner chamber 45 of tissue cutter 20 (at its near-end), preferably, distal tip is equipped with and outwards is trumpet-shaped guider 102, and this guider is slidably mounted on the axle 103 of marker delivery device 100.The near-end of Tubular tool 20, trumpet-shaped guider 102 and/or distal tip 101 can be equipped with the director element that matches, it is used to make the marker delivery device orientation, thereby when the pusher element that is located at slidably in the conveyer device is pushed so that when the outlet of at least one marked body from marker delivery device slender axles distal portions extruded at its far-end, one or more labellings are discharged from by hole 17.When the far-end of tissue biopsy device still was in the biopsy position, the labelling that takes place after specimen removes had guaranteed that to the conveying of target site labelling suitably is positioned at the biopsy position.Though it is to be arranged on the axle 103 of marker delivery device 100 that the trumpet-shaped proximal guide 102 that is slidingly installed is described to, but, trumpet-shaped guider 102 all has extensive use in multiple tissue biopsy device and other device, in these devices, in the tube-like piece of a minor diameter will be inserted into more bigger (but still being minor diameter) second tube-like piece.

The seeker parts 11 of tissue biopsy system 10 have the extremely approximately length of 20cm of about 3cm, and preferably, about 5cm is to about 13cm, and more specifically, for breast biopsy use, about 8cm is to about 9cm.In order to assist it suitably to be positioned in patient's body during probe 11 advances, the utmost point far-end of tubular portion can be equipped with labelling in desired location, and this labelling provides enhanced visual effect by vision, ultrasound wave, X ray or other imaging or visual device.Also can use manual palpation.Echo (echogenic) polymer coating of increase contrast resolution in ultrasonic imaging apparatus (such as Henrietta, the ECHOCOAT of the STS Biopolymers of NY ^TM) be applicable to that ultrasound wave shows.Radio opaque markers can be made by for example oxide of rustless steel, platinum, gold, iridium, tantalum, tungsten, silver, rhodium, nickel, bismuth, other radiopaque metal, alloy and these metals.In addition, can have suitable lubricant coating with other parts of organizing contacted apparatus surface or device, such as water wetted material or fluoropolymer.

Preferably, tubular portion and tissue cutter are made by the rustless steel of surgical grade.Yet other high-strength material such as MP35N, other cobalt-chromium alloy, NiTi alloy, pottery, glass and high strength polymeric or its combination also are fit to.

In order to be able near will obtaining the body part of tissue specimen therein, usually must be in patient's skin upper shed.Can use scalpel or other operating theater instruments in skin, to form initial otch.After obtaining specimen, can in patient's body, remove tissue biopsy device.Removable whole device; Yet, in certain embodiments, can from system 10, remove tube 58 and delivery cannula and can be inserted in the inner chamber of cutter 20, labelling is transported to the biopsy position by hole 17.In addition, understand easily, except that the apparatus of the above or replace above-described apparatus, the apparatus of other type also can be inserted in the tissue site by tissue cutter.In addition, can pass through tissue cutter 20 or tubular portion 15 delivering therapeutics or diagnostic agent.

Figure 14 shows screen 104 according to an embodiment of the invention, and this screen provides some useful information with respect to the tissue biopsy system operation.Screen 104 can be provided by the display of any kind, such as liquid crystal display (LCD), cathode ray tube (CRT) monitor and plasma scope.Display can be used in combination with the control module that is used for controlling electrosurgical instrument (such as the tissue biopsy system of Fig. 1).For example, can provide screen 104 by the CM3000 display that is used in combination with CM3000 control module (SenoRx, Inc make).

Screen 104 provides first Word message 106 of the various modes of operation that tissue biopsy system is shown.For example, mode of operation can comprise: initialization, calibrate, close, open, sampling, indexing, the error of division, device malfunction, vacuum failure and instrument exit status.These state representation are prepared tissue biopsy system, are obtained each stage of tissue specimen with tissue biopsy system in patient's body, and are preparing and taking out the error that occurs in the program process.The situation that second Word message 108 on the screen 104 has been explained in detail the concrete state shown in first Word message 106.For example, on screen 104, second Word message 108 informs that user waits finishing of opening, and in opening, tissue biopsy system is carried out opening process.Be used to indicate the indicator 110 of particular case or state to be positioned at the place, bottom of screen 104.For example, when the indicator 110 that is marked with VAC is connected, be to inform that vacuum system is current just to move.

Screen 104 further provides graphic user interface 112, and this graphic user interface illustrates the various piece of therefrom taking out or can therefrom take out one or more tissue specimens of patient's body target site.Graphic user interface 112 can further illustrate the position, angle of organizing cutting member 20 shown in Figure 2.Owing to organize cutting member 20 that its cutting tip is positioned in the target site of patient body to rotate mobile mode, therefore based on round-shaped design configuration user interface 112.Yet, it should be noted that and also can use other shape that the position, angle of organizing cutting member 20 can be shown basic configuration as graphic user interface 112.For example, can be based on polygonal shape design configuration user interface 112.The various designs of graphic user interface 112 will be described in following paragraph.

Figure 15 A to 15E shows a plurality of alternatives of graphic user interface 112 among Figure 14 according to an embodiment of the invention.In this embodiment, graphic user interface 112 comprises a GUI zone, the first area of a GUI region representation target site, and the using-system cutting member is isolated at least one tissue specimen from the tissue of target site from this first area.Graphic user interface 112 further comprises from visually distinguishing over the 2nd GUI zone in a GUI zone, the 2nd GUI region representation second area organizes cutting member can separate one or more additional tissue specimens from this second area from the tissue of target site.The first and second GUI zones are marked with the color or the pattern that can be distinguished from each other out.Their make tissue target site the part of having cut and can be as seen by the remainder of tissue biopsy system cutting.This helps the surgeon to understand the progress of biopsy operation better.

Figure 15 A shows the graphic user interface 114 according to first alternative of this embodiment.The 116 and the 2nd GUI zone 118, the one GUI zone is arranged in the circle.The one GUI zone 116 is segmental, and the part that is not occupied by a GUI zone 116 of circle is represented the 2nd GUI zone 118.In the figure, cut the less angle part of the target site of tissue, and the big angle part of tissue can be cut in operating process subsequently.

Figure 15 B shows the graphic user interface 120 according to second alternative of this embodiment.Dash area is represented a GUI zone 122, and non-shaded portion is represented the 2nd GUI zone 124.The one GUI zone 122 comprises the first 126 of fan shape at circular graphical user interfaces 120 circle centre positions.The limit of first 126 (arm) is less than the radius of graphic user interface 120.The one GUI zone 122 also comprises second portion 128, and the shape of this second portion is configured to the curved bel (band) that aligns with the arc of first 126.The angle of first 126 is represented the angle part of having cut of organizing.

Figure 15 C shows the graphic user interface 130 according to the 3rd alternative of this embodiment.Dash area is represented a GUI zone 132, and non-shaded portion is represented the 2nd GUI zone 134.The one GUI zone 132 comprises round-shaped first 136, and second portion 138, and the shape of this second portion is configured to be adjacent to the curved bel of the contour of first 136.Two side lines of second portion 138 limit an angle, and this angle is represented the angle part of having cut of organizing.

Figure 15 D shows the graphic user interface 140 according to the 4th alternative of this embodiment.Dash area is represented a GUI zone 142, and non-shaded portion is represented the 2nd GUI zone 144.The one GUI zone 142 comprises: round-shaped first 145; Second portion 146, the shape of this second portion are configured to be adjacent to the curved bel of the contour of first; And third part 147, the shape of this third part is provided as the curved bel that aligns with the outer peripheral lines of second portion 146.The side line of second portion 146 or third part 147 limits an angle, and this angle is represented the angle part of having cut of organizing.

Figure 15 E shows the graphic user interface 150 according to the 5th alternative of this embodiment.Dash area is represented a GUI zone 152, and non-shaded portion is represented the 2nd GUI zone 154.The one GUI zone comprises: round-shaped first 155; Center on the second portion 156 of the annular shape of first 155; And third part 157, the shape of this third part is provided as the curved bel of the contour that is adjacent to second portion 156.The side line of third part 157 limits an angle, and this angle is represented the angle part of having cut of organizing.

Figure 16 A to 16E shows another group alternative according to graphic user interface 112 among Figure 14 of the embodiment of the invention.Figure 16 A shows first alternative 160 of graphic user interface.The 162 and the 2nd GUI zone 164, the one GUI zone is arranged in the regular polygon.The one GUI zone 162 is partitioning portions of regular polygon, and it defines angle at its geometric center place.The remainder that is not occupied by a GUI zone 162 of regular polygon is represented the 2nd GUI zone 164.Aforesaid, the angle part of the target site tissue that 162 expressions of GUI zone have been cut, and the part of the tissue that 164 expressions of the 2nd GUI zone can be cut in operating process subsequently.

Figure 16 B shows the graphic user interface 170 according to second alternative of this embodiment.Dash area is represented a GUI zone 172, and non-shaded portion is represented the 2nd GUI zone 174.The one GUI zone 172 comprises the first 176 of polygonal shape, has the angle of the geometric center place qualification of regular polygon 179.The one GUI zone 174 also comprises second portion 178, and the shape of this second portion is provided as the polygon band along the contour of regular polygon 179, and aligns with first 176.The angle of first 176 is represented the angle part of having cut of organizing.

Figure 16 C shows the graphic user interface 180 according to the 3rd alternative of this embodiment.Dash area is represented a GUI zone 182, and non-shaded portion is represented the 2nd GUI zone 184.The one GUI zone 182 comprises the first 186 of polygonal shape, and it has the geometric center identical with regular polygon 189.The one GUI zone 182 also comprises second portion 188, and the shape of this second portion is provided as the polygon band along the contour of regular polygon 189, and it is adjacent to the outer peripheral lines of first 186.Two side lines of second portion 188 limit an angle, and this angle is represented the angle part of having cut of organizing.

Figure 16 D shows the graphic user interface 190 according to the 4th alternative of this embodiment.Dash area is represented a GUI zone 192, and non-shaded portion is represented the 2nd GUI zone 194.The one GUI zone 192 comprises first 195, second portion 196 and third part 197.First 195 is polygonal shapes, and has the geometric center identical with regular polygon 198.The shape of second portion 196 is configured to the polygon band, and it is adjacent to the outer peripheral lines of first 195.The shape of third part 197 is configured to the polygon band along the contour of regular polygon 198, and its outer peripheral lines with second portion 196 is alignd.Two side lines of second portion 196 or third part 197 limit an angle, and this angle is represented the angle part of having cut of organizing.

Figure 16 E shows the graphic user interface 200 according to the 5th alternative of this embodiment.Dash area is represented a GUI zone 202, and non-shaded portion is represented the 2nd GUI zone 204.The one GUI zone 202 comprises first 205, second portion 206 and third part 207.First 205 is polygonal shapes, and has the geometric center identical with regular polygon 208.The shape of second portion 206 is configured to the polygon ring around first 205.The shape of third part 207 is configured to the polygon band along the contour of regular polygon 208, and is adjacent to the outer peripheral lines of second portion 206.Two side lines of third part 207 limit an angle, and this angle is represented the angle part of having cut of organizing.

In above embodiment, though in each graphic user interface neither one illustrate organize cutting member when the anterior angle position, can by the external indicator shown in Fig. 8 29 know organize cutting member work as the anterior angle position.

Figure 17 A to 17E shows a plurality of alternatives of graphic user interface 112 among Figure 14 in accordance with another embodiment of the present invention.In this embodiment, graphic user interface 112 comprises first, second and the 3rd GUI zone.The first area of the one GUI region representation target site, the using-system cutting member is isolated at least one tissue specimen from the tissue of target site from this first area.From visually distinguishing over the 2nd GUI region representation second area in a GUI zone, from this second area, organize cutting member can from the tissue of target site, separate one or more additional tissue specimens.From visually distinguishing over the 3rd GUI region representation the 3rd zone in the first and second GUI zones, in the 3rd zone, be provided with and organize cutting member so that from the tissue of target site the chorista specimen.First, second and the 3rd GUI zone are marked with the color or the pattern that can be distinguished from each other out.The part of having cut of the target site of their feasible tissues, the remainder that cuts of tissue and position, the residing angle of cutting member are as seen.This helps the surgeon to understand the progress of biopsy operation better.

Figure 17 A shows the graphic user interface 210 according to first alternative of this embodiment.The one GUI zone 202, the 2nd GUI zone 204 and the 3rd GUI zone 206 are arranged in the circle 208.The 202 and the 3rd GUI zone 206, the one GUI zone is segmental.The part that is not occupied by the 202 and the 3rd GUI zone 206, GUI zone of circle is represented the 2nd GUI zone 204.

Figure 17 B shows the graphic user interface 220 according to second alternative of this embodiment.Graphic user interface 220 is different from that part is that it has 222, the three GUI zones 222, the 3rd GUI zone and comprises first 223 and second portion 224 among Figure 15 B.The first 223 in the 3rd GUI zone 222 is fan shape, and its first 225 with a GUI zone 226 is concentric.The shape of the second portion 224 in the 3rd GUI zone 222 is configured to the curved bel that the arc with the first 223 in the 3rd GUI zone 222 aligns.

Figure 17 C shows the graphic user interface 230 according to the 3rd alternative of this embodiment.Graphic user interface 230 is different from part among Figure 15 C and is that its shape with 232, the three GUI zones 232, the 3rd GUI zone is configured to be adjacent to the curved bel of contour of the first 234 in a GUI zone 236.

Figure 17 D shows the graphic user interface 240 according to the 4th alternative of this embodiment.Graphic user interface 240 is different from that part is that it has 242, the three GUI zones 242, the 3rd GUI zone and comprises first 243 and second portion 244 among Figure 15 D.The shape of the first 243 in the 3rd GUI zone 242 is configured to be adjacent to the curved bel of contour of the first 245 in a GUI zone 246.The shape of the second portion 244 in the 3rd GUI zone 242 also is configured to the curved bel that the outer peripheral lines with second portion 242 aligns.

Figure 17 E shows the graphic user interface 250 according to the 5th alternative of this embodiment.Graphic user interface 250 is different from part among Figure 15 E and is that its shape with 252, the three GUI zones 252, the 3rd GUI zone is configured to be adjacent to the curved bel of contour of the ring 254 in a GUI zone 256.

Figure 18 A to 18E shows another group alternative according to graphic user interface 112 among Figure 14 of the embodiment of the invention.Figure 18 A shows the graphic user interface 260 of first alternative.Graphic user interface 260 is different from that part is that it has 262, the three GUI zones, the 3rd GUI zone is partitioning portions of regular polygon 264 among Figure 16 A, and it defines angle at regular polygon 265 geometric center places.

Figure 18 B shows the graphic user interface 270 of second alternative.Graphic user interface 270 is different from that part is that it has 272, the three GUI zones, the 3rd GUI zone and comprises first 273 and second portion 274 among Figure 16 B.The first 273 in the 3rd GUI zone 272 is polygonal shapes, and its geometric center place at regular polygon 275 defines angle.The shape of the second portion 274 in the 3rd GUI zone 272 is configured to along the polygon band of the contour of regular polygon 275, and its outer peripheral lines with first 273 is alignd.

Figure 18 C shows the graphic user interface 280 of the 3rd alternative.Graphic user interface 280 is different from that part is that its shape with 282, the three GUI zones, the 3rd GUI zone is configured to along the polygon band of the contour of regular polygon 284 among Figure 16 C.

Figure 18 D shows the graphic user interface 290 of the 4th alternative.Graphic user interface 290 is different from that part is that it has 292, the three GUI zones, the 3rd GUI zone and comprises first 293 and second portion 294 among Figure 16 D.The shape of the first 293 in the 3rd GUI zone 292 is configured to be adjacent to the polygon band of the outer peripheral lines of inner polygon 296.The shape of the second portion 294 in the 3rd GUI zone 292 is configured to along the polygon band of the contour of regular polygon 295, and it is adjacent to the outer peripheral lines of first 293.

Figure 18 E shows the graphic user interface 300 of the 5th alternative.Graphic user interface 300 is different from that part is that its shape with 302, the three GUI zones, the 3rd GUI zone is configured to along the polygon band of the contour of regular polygon 304 among Figure 16 E, and it is adjacent to polygon ring 306.

Aforesaid, first, second and the 3rd GUI zone make the remainder that cuts of the part of having cut, tissue of target site of tissue and cutting member residing when the anterior angle position as seen.This helps the surgeon to understand the progress of biopsy operation better.

Though illustrated in the literary composition and described particular form of the present invention, should be understood that, can make various corrections and improvement to the present invention.For example, though described a plurality of embodiment according to tissue biopsy device in the literary composition, should be understood that, use the apparatus and method of this device to can be used for the removal tissue that carries out for other purpose beyond the biopsy, that is, be used for the treatment of or other diagnostic purpose.Other correction comprises, for example, a kind of tissue cutter, it is slidably mounted on around the tubular portion of probe member rather than is installed in the tubular portion.In addition, each feature of the embodiment of the invention may be shown in some figure, and do not illustrate in other figure, still, those skilled in the art it should be understood that in the one embodiment of the invention each feature can with the arbitrary of another embodiment or all characteristics combination.Therefore, the specific embodiment shown in invention is not to be considered as being limited to.Therefore should think that the present invention is limited by the scope of claims, and its wide ranges is to scope that prior art allowed.

When using in the text, should be not the clause that will quote 35U.S.C. § 112 (6) with waiting the Word Understanding of the term and the close meaning such as " element ", " part ", " device ", " partly (section) ", " portion " " parts ", " device means ", " step ", unless following claim is used term " device means " expressly, and its back is with concrete function rather than ad hoc structure are arranged, or use term " step " expressly, and its back is with concrete function rather than specific action are arranged.All patents mentioned in the literary composition and the full content of patent application are hereby expressly incorporated by reference.

Claims

1. graphic user interface (GUI) that is used to have the tissue biopsy system of organizing cutting member, described graphic user interface comprises:

A. a GUI zone, the first area of a described GUI region representation target site, the described cutting member of organizing has separated one or more tissue specimens from described first area;

B. the 2nd GUI zone visually can separate with a described GUI area region, the second area of the described target site of described the 2nd GUI region representation, the described cutting member separable one or more additional tissue specimens from described second area of organizing.

2. graphic user interface according to claim 1, wherein, a described GUI zone indicates color or pattern, so that described GUI zone is separated with described the 2nd GUI area region.

3. graphic user interface according to claim 1, wherein, the described first and second GUI area arrangements are in circle.

4. graphic user interface according to claim 3, wherein, a described GUI zone is a fan shape.

5. graphic user interface according to claim 3, wherein, a described GUI zone comprises the first and the second portion of fan shape, the shape of described second portion is provided as the curved bel that aligns with described first.

6. graphic user interface according to claim 3, wherein, a described GUI zone comprises round-shaped first and second portion, the shape of described second portion is provided as the curved bel of the contour that is adjacent to described first.

7. graphic user interface according to claim 3, wherein, a described GUI zone comprises round-shaped first and second portion and third part, the shape of described second portion is provided as the curved bel of the contour that is adjacent to described first, and the shape of described third part is provided as the curved bel that aligns with the outer peripheral lines of described second portion.

8. graphic user interface according to claim 3, wherein, a described GUI zone comprises round-shaped first and second portion and third part, described second portion is the annular shape around described first, and the shape of described third part is provided as the curved bel of the outer peripheral lines that is adjacent to described second portion.

9. graphic user interface according to claim 1, wherein, the described first and second GUI area arrangements are in regular polygon.

10. graphic user interface according to claim 9, wherein, a described GUI zone is the partitioning portion of described regular polygon, defines angle at the geometric center place of described regular polygon.

11. graphic user interface according to claim 9, wherein, a described GUI zone comprises first and second portion, described first be polygonal shape and define angle at the geometric center place of described regular polygon, the shape of described second portion is provided as the polygon band along the contour of described regular polygon, and aligns with described first.

12. graphic user interface according to claim 9, wherein, a described GUI zone comprises first and second portion, described first be polygonal shape and have a geometric center identical with the geometric center of described regular polygon, the shape of described second portion is provided as the polygon band along the contour of described regular polygon, and is adjacent to the contour of described first.

13. graphic user interface according to claim 9, wherein, a described GUI zone comprises first, second portion and third part, described first be polygonal shape and have a geometric center identical with the geometric center of described regular polygon, the shape of described second portion is provided as the polygon band of the contour that is adjacent to described first, and the shape of described third part is provided as along the polygon band of the contour of described regular polygon and with described second portion aligns.

14. graphic user interface according to claim 9, wherein, a described GUI zone comprises first, second portion and third part, described first be polygonal shape and have a geometric center identical with the geometric center of described regular polygon, the shape of described second portion is provided as the polygon ring around described first, and the shape of described third part is provided as along the polygon band of the contour of described regular polygon and contiguous with the outer peripheral lines of described second portion.

15. graphic user interface according to claim 1, wherein, described tissue biopsy system comprises external indicator, described external indicator illustrate described organize cutting member when the anterior angle position.

16. graphic user interface according to claim 1, also comprise from visually distinguishing over the 3rd GUI zone in the first and second GUI zones, described the 3rd GUI region representation the 3rd zone, in described the 3rd zone, be provided with the described cutting member of organizing, so as from the tissue of described target site the chorista specimen.

17. graphic user interface according to claim 16, wherein, described the 3rd GUI zone is marked with color or pattern, and described color or pattern can separate with those colors or the pattern area in the described first and second GUI zones of sign.

18. graphic user interface according to claim 16, wherein, described first, second and the 3rd GUI zone are disposed in the circle.

19. graphic user interface according to claim 18, wherein, described the 3rd GUI zone is a fan shape.

20. graphic user interface according to claim 18, wherein, described the 3rd GUI zone comprises first and second portion, and described first is a fan shape, and the shape of described second portion is provided as the curved bel that the first with described the 3rd GUI zone aligns.

21. graphic user interface according to claim 18, wherein, the shape in described the 3rd GUI zone is provided as along the curved bel of the contour of described circle.

22. graphic user interface according to claim 18, wherein, described the 3rd GUI zone comprises first and second portion, the shape of described first is provided as along the curved bel of the contour of described circle, and the shape of described second portion is provided as the curved bel that the interior contour with the first in described the 3rd GUI zone aligns.

23. graphic user interface according to claim 16, wherein, described first, second and the 3rd GUI zone are disposed in the regular polygon.

24. graphic user interface according to claim 23, wherein, described the 3rd GUI zone is the partitioning portion of described regular polygon, defines angle at the geometric center place of described regular polygon.

25. graphic user interface according to claim 23, wherein, described the 3rd GUI zone comprises first and second portion, described first be polygonal shape and define angle at the geometric center place of described regular polygon, the shape of described second portion is provided as along the polygon band of the contour of described regular polygon and with the first in described the 3rd GUI zone and aligns.

26. graphic user interface according to claim 23, wherein, the shape in described the 3rd GUI zone is provided as the polygon band along the contour of described regular polygon.

27. graphic user interface according to claim 23, wherein, described the 3rd GUI zone comprises first and second portion, the shape of described first is provided as the polygon band along the contour of described regular polygon, and the shape of described second portion is provided as the polygon band that the interior contour with the first in described the 3rd GUI zone aligns.

28. a graphic user interface (GUI) that is used to have the tissue biopsy system of organizing cutting member, the described cutting member of organizing is suitable for the one or more tissue specimens of cutting from the tissue of patient's body target site, and described graphic user interface comprises:

A. a GUI zone, the first area of the described target site of a described GUI region representation, the described cutting member of organizing has separated at least one tissue specimen from the tissue of described target site from described first area;

B. the 2nd GUI zone, visually can separate with a described GUI area region, described the 2nd GUI region representation second area, the described cutting member of organizing can separate one or more additional tissue specimens from the tissue of described target site from described second area; And

C. the 3rd GUI zone visually can separate with the described first and second GUI area region, described the 3rd GUI region representation the 3rd zone, and the described cutting member of organizing is arranged in described the 3rd zone, with chorista specimen from the tissue of described target site.

29. graphic user interface according to claim 28, wherein, described first, second and the 3rd GUI zone indicate the color or the pattern that can be distinguished from each other out.

30. graphic user interface according to claim 28, wherein, described first, second and the 3rd GUI area arrangements are in circle.

31. graphic user interface according to claim 30, wherein, the described first and the 3rd GUI zone is a fan shape.

32. graphic user interface according to claim 30, wherein, a described GUI zone comprises first and second portion, described first is a fan shape, the shape of described second portion is provided as the curved bel that aligns with described first, and described the 3rd GUI zone comprises third part and the 4th part, described third part is fan shape and concentric with described first, and described tetrameric shape is provided as the curved bel that aligns with described third part.

33. graphic user interface according to claim 30, wherein, a described GUI zone comprises first and second portion, described first is round-shaped, the shape of described second portion is provided as the curved bel of the contour that is adjacent to described first, and the shape in described the 3rd GUI zone is provided as the curved bel of the contour that is adjacent to described first.

34. graphic user interface according to claim 30, wherein, a described GUI zone comprises first, second portion, and third part, described first is round-shaped, the shape of described second portion is provided as the curved bel of the contour that is adjacent to described first, the shape of described third part is provided as the curved bel that aligns with the outer peripheral lines of described second portion, and described the 3rd GUI zone comprises the 4th part and the 5th part, described tetrameric shape is provided as the curved bel of the contour that is adjacent to described first, and the shape of described the 5th part is provided as the curved bel that aligns with described tetrameric outer peripheral lines.

35. graphic user interface according to claim 30, wherein, a described GUI zone comprises first, second portion and third part, described first is round-shaped, described second portion is around the annular shape of described first, the shape of described third part is provided as the curved bel of the contour that is adjacent to described second portion, and the shape in described the 3rd GUI zone is provided as the curved bel of the contour that is adjacent to described second portion.

36. graphic user interface according to claim 28, wherein, described first, second and the 3rd GUI area arrangements are in regular polygon.

37. graphic user interface according to claim 36, wherein, the described first and the 3rd GUI zone is the partitioning portion of described regular polygon, defines angle at the geometric center place of described regular polygon.

38. graphic user interface according to claim 36, wherein, a described GUI zone comprises first and second portion, described first be polygonal shape and define angle at the geometric center place of described regular polygon, the shape of described second portion is provided as along the polygon band of the contour of described regular polygon and with described first and aligns, and described the 3rd GUI zone comprises third part and the 4th part, described third part be polygonal shape and define angle at the geometric center place of described regular polygon, described tetrameric shape is provided as along the polygon band of the contour of described regular polygon and with described third part and aligns.

39. graphic user interface according to claim 36, wherein, a described GUI zone comprises first and second portion, described first be polygonal shape and have a geometric center identical with the geometric center of described regular polygon, the shape of described second portion is provided as along the polygon band of the contour of described regular polygon and is adjacent to the contour of described first, and the shape in described the 3rd GUI zone is provided as along the polygon band of the contour of described regular polygon and is adjacent to the outer peripheral lines of described first.

40. graphic user interface according to claim 36, wherein, a described GUI zone comprises first, second portion, and third part, described first be polygonal shape and have a geometric center identical with the geometric center of described regular polygon, the shape of described second portion is provided as the polygon band of the outer peripheral lines that is adjacent to described first, the shape of described third part is provided as along the polygon band of the contour of described regular polygon and with described second portion and aligns, and described the 3rd GUI zone comprises the 4th part and the 5th part, described tetrameric shape is provided as the polygon band of the outer peripheral lines that is adjacent to described first, and the shape of described the 5th part is provided as along the polygon band of the contour of described regular polygon and with described third part and aligns.

41. graphic user interface according to claim 36, wherein, a described GUI zone comprises first, second portion, and third part, described first be polygonal shape and have a geometric center identical with the geometric center of described regular polygon, the shape of described second portion is provided as the polygon ring around described first, the shape of described third part is provided as along the polygon band of the contour of described regular polygon and contiguous with the outer peripheral lines of described second portion, and the shape in described the 3rd GUI zone is provided as along the polygon band of the contour of described regular polygon and is adjacent to the outer peripheral lines of described second portion.