CN101032537A - Gynura procumbens (Lour.) Merr. Flavonoid substances preparing method and the application - Google Patents
Gynura procumbens (Lour.) Merr. Flavonoid substances preparing method and the application Download PDFInfo
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- CN101032537A CN101032537A CN 200710051822 CN200710051822A CN101032537A CN 101032537 A CN101032537 A CN 101032537A CN 200710051822 CN200710051822 CN 200710051822 CN 200710051822 A CN200710051822 A CN 200710051822A CN 101032537 A CN101032537 A CN 101032537A
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- gynura procumbens
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Abstract
The present invention discloses one kind of gynura flavone and its preparation process and application. The gynura flavone is the total gynura flavone obtained with gynura herb and through water extracting to obtain water extracted liquid, adsorption in polyamide column, water washing and 95 % concentration alcohol solution eluting and recovering alcohol. The gynura flavone is used in treating cardiac and cerebral vascular diseases, hyperlipemia, hypertension and diabetes.
Description
Technical field
The present invention relates to a kind of Gynura procumbens (Lour.) Merr. Flavonoid substances preparation method and application thereof.
Background technology
At present, the nearly hyperlipidemia more than 300,000,000 in the whole world diabetics of answering the source hypertension or causing by pancreatic beta cell damage.Therefore, the research and development to the medicine of cardiovascular and cerebrovascular disease, hyperlipidemia, hypertension, diabetes are very necessary.
Gynura procumbens (Lour.) Merr. is Compositae, Radix Notoginseng platymiscium, Herba Gynurae procumbentis, Gynura procumbcns (Lour) morr, be the perennial herb medicine food dual purpose plant, diseases such as this plant treatment traumatic injury of usefulness among the people, rheumatic arthritis, bronchitis, pneumonia, nephritis; " China's book on Chinese herbal medicine " record Gynura procumbens (Lour.) Merr. has dredge the meridian passage, diffusing silt detumescence, bronchitis, pneumonia, pulmonary tuberculosis, toxic swelling pain skin ulcer that better curative effect is arranged.In recent years, find that abroad this plant has curative effect preferably to acute coryza, erythra, nephropathy, hypertension, diabetes.
Summary of the invention
Purpose of the present invention just provides a kind of preparation method of Chinese herbal medicine Gynura procumbens (Lour.) Merr. Flavonoid substances, and the application of Gynura procumbens (Lour.) Merr. Flavonoid substances in treatment cardiovascular and cerebrovascular disease, hyperlipidemia, hypertension, diabetes.
The preparation method of Gynura procumbens (Lour.) Merr. Flavonoid substances of the present invention: the water that Gynura procumbens (Lour.) Merr. herb coarse powder is added 8～10 times of amounts, heating decocts extracted 2-4 hour, solid-liquid separation, and the water extract adsorbs by polyamide column, alcoholic acid total yellow cave class material is reclaimed with 95% ethanol elution in washing back.
The preparation method of Gynura procumbens (Lour.) Merr. Flavonoid substances of the present invention: the water that Gynura procumbens (Lour.) Merr. herb coarse powder is added 8～10 times of amounts, heating decocts extracted 2-4 hour, solid-liquid separation, water extract evaporation and concentration is to a small amount of, with n-butyl alcohol or ethyl acetate extraction, extract reclaims organic solvent and obtains total flavonoids substance then.
The Gynura procumbens (Lour.) Merr. Flavonoid substances of above-mentioned preparation method preparation can be used for preparing in the medicine of treatment cardiovascular and cerebrovascular disease, hyperlipidemia, hypertension, diabetes.
The Gynura procumbens (Lour.) Merr. extract is carried out The Chemical Constituents to be shown: Gynura procumbens (Lour.) Merr. contains number of chemical compositions such as various volatile oil, yellow cave glycosides, alkaloid, organic acid (chlorogenic acid and derivant 3～5-dioxygen-caffeoylquinic acids thereof and 4～5-dioxygen-caffeoylquinic acids) and hydroxyl lactic acid.
Pharmacological evaluation shows: Gynura procumbens organic acid has therapeutical effect preferably to the bleb disease that caused by virus, erythra etc.And yellow cave constituents: kaempferol-3-O-glucoside, cage for wild beasts skin element ,-3-O-rhamnose (1-6) glucoside, Pi Su ,-3-O-rhamnose (1-6) galactoside, kaempferol-3-O-rhamnose (1-6) glucoside etc. have the remarkable effect of repairing pancreatic beta cell and blood sugar lowering concentration preferably, and its alkaloids composition has stronger antibiotic analgesic effect.
The preparation method of Gynura procumbens (Lour.) Merr. Flavonoid substances of the present invention is simple, easy to operate, and prepared Flavonoid substances can be used for treating cardiovascular and cerebrovascular disease, hyperlipidemia, hypertension, diabetes.
The specific embodiment
Embodiment 1:
A kind of preparation method of Gynura procumbens (Lour.) Merr. Flavonoid substances: the water that Gynura procumbens (Lour.) Merr. herb coarse powder is added 8～10 times of amounts, heating decocts extracted 2-4 hour, solid-liquid separation, and the water extract adsorbs by polyamide column, alcoholic acid total yellow cave class material is reclaimed with 95% ethanol elution in washing back.
Embodiment 2:
A kind of preparation method of Gynura procumbens (Lour.) Merr. Flavonoid substances: the water that Gynura procumbens (Lour.) Merr. herb coarse powder is added 8～10 times of amounts, heating decocts extracted 2-4 hour, solid-liquid separation, water extract evaporation and concentration is to a small amount of, with n-butyl alcohol or ethyl acetate extraction, extract reclaims organic solvent and obtains total flavonoids substance then.
Claims (3)
1, a kind of preparation method of Gynura procumbens (Lour.) Merr. Flavonoid substances, it is characterized in that: the water that the steps include: Gynura procumbens (Lour.) Merr. herb coarse powder is added 8～10 times of amounts, heating decocts extracted 2-4 hour, solid-liquid separation, the water extract adsorbs by polyamide column, alcoholic acid total yellow cave class material is reclaimed with 95% ethanol elution in washing back.
2, a kind of preparation method of Gynura procumbens (Lour.) Merr. Flavonoid substances, it is characterized in that: the water that the steps include: Gynura procumbens (Lour.) Merr. herb coarse powder is added 8～10 times of amounts, heating decocts extracted 2-4 hour, solid-liquid separation, water extract evaporation and concentration is to a small amount of, with n-butyl alcohol or ethyl acetate extraction, extract reclaims organic solvent and obtains total flavonoids substance then.
3, the Gynura procumbens (Lour.) Merr. Flavonoid substances as claim 1 or 2 preparations is preparing the application for the treatment of in cardiovascular and cerebrovascular disease, hyperlipidemia, hypertension, the diabetes medicament.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710051822 CN101032537A (en) | 2007-04-08 | 2007-04-08 | Gynura procumbens (Lour.) Merr. Flavonoid substances preparing method and the application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710051822 CN101032537A (en) | 2007-04-08 | 2007-04-08 | Gynura procumbens (Lour.) Merr. Flavonoid substances preparing method and the application |
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| CN101032537A true CN101032537A (en) | 2007-09-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200710051822 Pending CN101032537A (en) | 2007-04-08 | 2007-04-08 | Gynura procumbens (Lour.) Merr. Flavonoid substances preparing method and the application |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582083A (en) * | 2015-09-08 | 2016-05-18 | 石友爱 | Traditional Chinese medicine for treating bowenoid papulosis |
| CN105749258A (en) * | 2016-03-02 | 2016-07-13 | 卢连伟 | Sugar-reducing composition containing glipizide and preparation method thereof |
| CN106924314A (en) * | 2015-12-30 | 2017-07-07 | 北京万源普达医疗科技有限公司 | A kind of Gynura procumbens (Lour.) Merr sugar-free buccal tablet |
| CN110818668A (en) * | 2019-11-06 | 2020-02-21 | 江西省科学院应用化学研究所 | Method for separating and purifying high-purity flavonoid glycoside compounds from gynura procumbens stems |
| CN112057486A (en) * | 2019-06-11 | 2020-12-11 | 百岳特生物技术（上海）有限公司 | Application of gynura procumbens extract in preparing composition for improving sleep quality and preparing composition for protecting health and promoting blood circulation |
| CN113730533A (en) * | 2021-09-28 | 2021-12-03 | 完美（广东）日用品有限公司 | Composition for relieving osteoarthritis pain and application thereof |
| CN114306539A (en) * | 2022-02-18 | 2022-04-12 | 信丰金华园农业发展有限公司 | Application of gynura procumbens in preparation of anti-nephritis composition |
-
2007
- 2007-04-08 CN CN 200710051822 patent/CN101032537A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582083A (en) * | 2015-09-08 | 2016-05-18 | 石友爱 | Traditional Chinese medicine for treating bowenoid papulosis |
| CN106924314A (en) * | 2015-12-30 | 2017-07-07 | 北京万源普达医疗科技有限公司 | A kind of Gynura procumbens (Lour.) Merr sugar-free buccal tablet |
| CN105749258A (en) * | 2016-03-02 | 2016-07-13 | 卢连伟 | Sugar-reducing composition containing glipizide and preparation method thereof |
| CN112057486A (en) * | 2019-06-11 | 2020-12-11 | 百岳特生物技术（上海）有限公司 | Application of gynura procumbens extract in preparing composition for improving sleep quality and preparing composition for protecting health and promoting blood circulation |
| CN110818668A (en) * | 2019-11-06 | 2020-02-21 | 江西省科学院应用化学研究所 | Method for separating and purifying high-purity flavonoid glycoside compounds from gynura procumbens stems |
| CN110818668B (en) * | 2019-11-06 | 2021-04-27 | 江西省科学院应用化学研究所 | Method for separating and purifying high-purity flavonoid glycoside compounds from gynura procumbens stems |
| CN113730533A (en) * | 2021-09-28 | 2021-12-03 | 完美（广东）日用品有限公司 | Composition for relieving osteoarthritis pain and application thereof |
| CN114306539A (en) * | 2022-02-18 | 2022-04-12 | 信丰金华园农业发展有限公司 | Application of gynura procumbens in preparation of anti-nephritis composition |
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