CN101010568B - Apparatus and method for correction of abberations in laser system optics - Google Patents

Apparatus and method for correction of abberations in laser system optics Download PDF

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CN101010568B
CN101010568B CN2005800276434A CN200580027643A CN101010568B CN 101010568 B CN101010568 B CN 101010568B CN 2005800276434 A CN2005800276434 A CN 2005800276434A CN 200580027643 A CN200580027643 A CN 200580027643A CN 101010568 B CN101010568 B CN 101010568B
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laser beam
predetermined pattern
distributions
ability
focal plane
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CN101010568A (en
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R·扎多严
G·V·霍兰德
Z·博
M·布维尔
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AMO Development LLC
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F9/00825—Methods or devices for eye surgery using laser for photodisruption
    • A61F9/0084—Laser features or special beam parameters therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00681—Aspects not otherwise provided for
    • A61B2017/00725—Calibration or performance testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00844—Feedback systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00855—Calibration of the laser system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00872—Cornea

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Abstract

The present invention provides a method for minimizing fluence distribution of a laser over a predetermined pattern. In particular, the method is useful for minimizing fluence variance over a predetermined pattern for lasers used in ophthalmic surgery.

Description

Be used to correct the apparatus and method of the deviation of laser system optical device
Technical field
The present invention relates to a kind of laser beam energy correction method, it is used for proofreading and correct because the variation of the ability distributions on the focal plane that the deviation of focusing optics causes, and a kind of laser driving apparatus that adopts said laser beam energy correction method.Said method and apparatus of the present invention but is not used for the ophthalmology laser surgery process especially uniquely.
Background technology
An application-specific of the present invention is in ophthalmic surgical procedures, uses the excision plane of the laser-defined vitreous layer of photodisruption (photodisruptive), is used for the rectification of eyesight error to produce cornea flap.Vision impairment can be produced by many reasons, also is the result that many causes cause.A kind of defect condition that a VI common cause is eyes causes, this defect condition takes place when the ametropia characteristic of cornea does not make the infinite ray of light focus on the retina.When eyes were static, the ray focusing of light was in amphiblestroid front, and this situation is called myopia (being myopia).On the other hand, when the ray focusing of light during in amphiblestroid back, this situation is called long sight (being farsightedness).Myopia and two kinds of situations of long sight all can cause vision impairment in various degree.In most of the cases, these two kinds of situations all can be corrected.
Glasses or contact lenses are commonly used to myopia correction or long sight situation.Yet because a variety of causes, the many people that suffer from these situations are reluctant wear a pair of spectacles or contact lenses.The optional method of correcting these situations comprises the known surgical process of reinventing cornea with the whole bag of tricks, and these methods are effective to the ametropia characteristic that changes cornea.For example, in the United States Patent (USP) 4,665,913 and patent 4,669,466 of L ' Esperance, described a kind of laser system, it is from inside surface light excision cornea tissue of eyes.Another process is described in the United States Patent (USP) 4,988,348 of Bille, and wherein cornea tissue at first is removed to correct defects of vision, and the new then surface that produces is by smoothing.
Correct refractive defects except the each several part of the previous section that removes and reinvent eyes, use the photodisruption technology in the matrix of being called also to be developed with other process of matrix organization in being used to remove.An example of this process has description in people's such as Bille United States Patent (USP) 4,907,586.Another example that is used for removing the process of matrix organization is the process of describing in the United States Patent (USP) 6,110,166 of Juhasz.In this process, can limit the anterior angle rete through using laser to produce a series of overlapping photodisruption zones.Then, the surgeon comes angle of departure rete through starting it, the cornea tissue below arriving, and variation has taken place through the light excision in this tissue.Vitreous layer is reorientated on cornea then.
This photodisruption process comprises uses the pulse laser beam to remove the tissue in the matrix in the eye's cornea, and this pulse laser beam is sequentially focused on each spot of intramatrical a plurality of positions.Each focused spot has limited volume, rather than single point.Further, each spot has one roughly at the central point at this limited bulk center.When flowing greater than critical value or threshold value, and the volume of the matrix organization that divides on each spot is when approximating the volume of this spot greatly, and the photodisruption of matrix organization can occur on beam-focusing each spot.The amount of disorganization depends on can flow the size that surpasses threshold value.For the fixed gap of giving between the photodisruption spot, there is optimum ability flow valuve, to obtain best surgical effect.For example, be lower than said optimal value, then be difficult to start tissue if this can flow.If this can flow greater than said optimal value, then in the photodisruption process, can produce too much gas flow, made in the cornea next procedure of vision correction process opaque, therefore complicated, the light excision.Clinical research shows, when can rheologyization+/-10% the time, significant variation can appear in the result.Therefore, it is very important between each photodisruption point, having consistent ability distributions.
This pulse laser system (it comprises laser and focusing optics) provides uniform ability distributions ideally on the focal plane, therefore provide consistent photodisruption effect to distribute.Yet even the laser system of in these processes, using is set to constant energy, but because the variation of the focused spot in the focal plane can appear at the problem that the focal plane provides non-activation stream.Therefore, on some points of focal plane, variation meeting that can distributions is greater than optimal value, and on other aspect of laser focal plane, can be lower than optimal value.Subsequently, this can produce incomparable inconsistent photodisruption distribution on the focal plane.Although the eyeglass that a reason of ability rheologyization is a laser focusing passes substantially evenly, comprise by the defective of beam deviation generation and little variation.Deviation generally can change the size of spot in the focal plane.Through correcting energy, the present invention minimizes the ability rheologyization at every bit place on the focal plane, changes owing to the laser beam deviation causes spot size at the every bit place.
United States Patent (USP) 6; 287; 299 have described a kind of part guiding through can be with laser beam can flow monitoring equipment, so that the picture of the ability distributions on the curved surface in the overlapping pattern to be provided, monitors the method that can flow from a focused spot to another focused spot.Ability stream is through the quantity of the pulse of control irradiation a single point and controls through overlapping these spots.For this method, a plurality of pulses with the same point on the irradiation X/Y plane are very necessary.Yet 6,287, No. 299 patents are failed to solve and are proofreaied and correct because the problem of the ability rheologyization that the difference in the focusing optics causes.And the space between condenser lens and focal plane has in limited time very much, and monopulse photodisruption and high-NA focusing optics during this method is provided with real-time operation are otiose.
Among this paper, the inventor has showed a kind of method and apparatus that is used to overcome the prior art shortcoming.
Summary of the invention
One embodiment of the present of invention are a kind of laser beam energy correction methods; It is used to proofread and correct the ability distributions that arrives the said laser beam on the focal plane through eyeglass, and said bearing calibration may further comprise the steps: the ability distributions of confirming to spread all over the said laser beam energy on the focal plane; With based on said can distributions, calibration is used for the said laser beam energy of predetermined pattern.
In a certain embodiments, confirm that the said step of ability distributions may further comprise the steps: focus on through eyeglass and get into the laser beam that can flow sensitive material that is positioned at said focal plane; The said laser beam of pulse transmission makes it pass through said eyeglass and arrives on the said focal plane; Destroy optically and saidly can flow sensitive material; Produce and to flow responsive plasma light; Measurement spreads all over the plasma light intensity distributions on the said focal plane; And the ability distributions of said focal plane stored in the computer memory.In one embodiment of the invention, said pulse transmission comprises a constant energy.In one embodiment of the invention, said pulse transmission comprises the constant energy of per second at least about 5000 pulses.
In a certain embodiments, confirm can distributions said step further comprise and repeat said focusing, pulse transmission, measurement and storing step.
In one embodiment of the invention, measure and distributions to comprise with the light image of photo-detector seizure plasma.
In one embodiment of the invention, measure and can distributions to comprise flowing of a plurality of coordinate points place of measuring on the said focal plane.In a certain embodiments, said a plurality of coordinate points comprise at least 1000 points.
In one embodiment of the invention; The said laser beam energy that calibration is used for predetermined pattern comprises from said computer memory fetches ability the distributions on the said focal plane of spreading all over of storage, and is modified in the said laser beam energy on the interior a single point of predetermined pattern.
In one embodiment of the invention, calibration comprises ability distributions and reference value on each aspect in the predetermined pattern of said storage is compared.In a certain embodiments, the said laser beam energy that calibration is used for predetermined pattern comprise minimize spread all on the predetermined pattern can rheologyization.In a certain embodiments, the said laser beam energy that calibration is used for predetermined pattern comprises the energy output of controlling said laser beam through feedback control strategies.
In one embodiment of the invention, said focal plane comprises a roughly flat surface.In one embodiment of the invention, predetermined pattern comprises spiral.
One embodiment of the present of invention are a kind of devices that are used to carry out said method described herein, comprise lasing light emitter, focusing, electrooptic modulator and are used for the computer-controlled driver of said electrooptic modulator.Imagine said computer-controlled driver and also can comprise suitable software program, it is used to analyze measured ability distributions data, and as the result of said analysis, calibrates said laser beam energy.Said device can also comprise can flow sensitive image and feedback mechanism.
One embodiment of the present of invention are a kind of laser beam energy correction methods; It is used to proofread and correct the ability distributions that said laser beam spreads all over a predetermined pattern on the object; Said bearing calibration may further comprise the steps: confirming to spread all over said on the focal plane can distributions, and said focal plane comprises that plasma is photodistributed and can flow sensitive image; Calibration spreads all over the said laser beam energy on the said predetermined pattern; Focus on said laser beam to said object; With the laser beam of pulse transmission, it is spreaded all on the said predetermined pattern on the said object through overregulating.
Accompanying drawing is described
This patent or application documents comprise the figure that at least one width of cloth colour is taken pictures.If require and the payment necessary fee, this patent or the disclosed duplicate of patented claim with (several) color graphics can be provided by official.In order more completely to understand the present invention, with reference now to description, wherein below in conjunction with accompanying drawing:
Fig. 1 is to use the patient's that method of the present invention treats skeleton view;
Fig. 2 is the block scheme that adopts the said laser system of method of the present invention;
Fig. 3 is an exemplary light excision response energy distributions that shows the inhomogeneous ability distributions of crossing over said focal plane;
Fig. 4 shows when said feedback mechanism is activated, the difference in the ability distributions;
Fig. 5 shows said plasma light intensity, and it depends on the pulsed laser energy in the quartz glass sample of the typical spot of 2.5 microns sizes; With
Fig. 6 shows the block scheme and the synoptic diagram of the high pressure linear amplifier of controlling said electrooptic modulator.
Embodiment
At first with reference to figure 1, the image that it has described prior art has shown the device 10 that is used to produce laser beam 12.Laser beam 12 is directed on patient 16 the eyes 14.For purposes of the present invention; Device 10 can produce pulse laser beam 12, and its physical characteristics that has is similar to United States Patent (USP) 4,764; No. 930 those open and require the laser system of protection to produce laser beam, this patent is given the transferor that receives of the present invention by permission exclusively.Various lasing light emitters can use with system and method for the present invention together, comprise infrared ray, visible light and ultraviolet laser.Further and the lasing light emitter that uses together of system of the present invention can be continuous wave, Q-switched pulse and locked mode ultrashort pulse laser.Although below be not exhaustive list, the laser instrument of front type can with the present invention in use together.
In one embodiment, the present invention considers to use pulse laser beam 12, and it has a duration and grows to several nanoseconds or be as short as the pulse that is merely several femtoseconds.
In one embodiment, laser cell is used for the photodisruption of said cornea by software control, and it adopts the laser beam of constant energy, is approximately 600 femtoseconds by the duration, and repetition rate is formed up to the light row of the pulse of hundreds of thousands hertz.
The optics transfer system confirms that laser on patient's cornea is focused a three-dimensional position at place.When laser during by pulse transmission, the energy that is sent on the point of focusing is enough to ionization tissue (photodisruption) on very little volume.Focus point is set repeatedly and pulse transmission laser causes producing the tissue plane of excision.
In one embodiment of the invention, said method is useful in using in real time, so that the information stores that can rheologyization needs of the ophthalmologic operation laser of describing in the fair copy invention is in computer memory, and can before operation, fetch immediately.Therefore in ophthalmic surgical procedures, the ability rheologyization of laser beam can be corrected imagination.Those skilled in the art can understand and can flow or energy intensity is that irradiance multiply by the time shutter, usually with joule/square centimeter tolerance.In another embodiment, before operation, laser by pulse transmission to the focal plane.The ability distributions that spreads all over predetermined pattern is determined, and the laser beam energy is calibrated, so that the laser that spreads all between each focused spot of said predetermined pattern can rheologyization be minimized.Then, at intra-operative, be focused through flat lens through the laser of calibrating.In another embodiment of the present invention, be based on the ability rheology data of storing in the computer memory, the laser that spreads all over predetermined pattern is calibrated, and therefore before each operation, laser does not need to be recalibrated.
In one embodiment of the invention, be included in a plurality of coordinate points on the X/Y axle with reference to the focal plane.In certain embodiments of the present invention, the specific Z coordinate of laser in flat lens is focused on a plurality of spots on the X/Y axle, and flat lens are preferably processed by quartz glass.Laser with greater than the energy of the optical destructive threshold value in the quartz glass by pulse transmission to the focal plane.On each point, produce and can flow proportional plasma light, and measure its intensity.Ionic light intensity distributions on different X/Y coordinates has been represented the ability rheologyization in the focal plane.Can be stored in the computer memory by flow data then.Laser energy is conditioned so that spread all over can rheologyization be minimized through calibration of predefined paths.One skilled in the art will realize that on some coordinate points the laser beam energy is certain to be increased or reduce, and its objective is the said laser beam of calibration, can rheologyization be minimized so that spread all over the said of predetermined pattern.In a certain embodiments, when imagination surpasses predefined scope when the variation that can flow, then said laser beam energy will be corrected, so that said can rheologyization being minimized.In certain embodiments of the present invention, for said predefined scope being set rheologyization, it is set to the 5-10% greater than expectation ability rheologyization on specific coordinate points; 10-15% greater than expectation ability rheologyization; Greater than the 15-20% that expects the ability rheologyization, greater than the 20-25% of expectation ability rheologyization, greater than the 25-30% of expectation ability rheologyization; 30-35% greater than expectation ability rheologyization; Greater than the 35-40% that expects the ability rheologyization, greater than the 40-45% of expectation ability rheologyization, or greater than the 45-50% that expects the ability rheologyization.
Imagination is in a certain embodiments, and with being calibrated on the specific Z coordinate points of said laser beam in the X/Y axle, and said then laser can be conditioned to focus on the different Z coordinates, is used for operation.Yet the present invention is not limited to the calibration on single Z coordinate.
In one embodiment of the invention, confirm on the focal plane can distributions said step be through confirming that the flowing of a plurality of spots place on the said focal plane accomplish.In a certain embodiments, the diameter of said focal plane is about 10mm.In a certain embodiments, the spot gap is about 10 microns.
In another embodiment of the present invention, the reference library of ability flow measurement is stored in the computer memory corresponding to specific predefined paths.Imagine said reference library and can comprise the information that can be customized, this depends on the process that laser is used.
In one embodiment of the invention, saidly roughly put down with reference to the focal plane.In other embodiments of the invention, imagination is said is curved surface with reference to the focal plane.
Imagination to the useful said predetermined pattern of the present invention including, but not limited to, circle, ellipse, grating, spiral or their combination.
Further, the present invention admits if the suitable layering of the irradiance of beam, its focused spot size and photodisruption position is effectively controlled, and then interior tissue " photodisruption " can use pulsed laser energy to be realized effectively.Correspondingly, an object of the present invention is to provide a kind of improving one's methods of photodisruption in the matrix that be used on the eyes cornea carrying out, the method for this ability distributions through a kind of focal plane that is used for the calibration of laser beam is provided realizes.
The physical property of laser beam, and focus on the mode of this laser beam, it is very important that method of the present invention is reached suitable performance.Point out that as above these considerations are inter-related.In the scope of considering laser beam character, Several Factors is very important.Laser beam should have permission light can be by the wavelength of cornea tissue absorption through cornea.Usually, said wavelength should be in the scope of 0.4-1.9 micron, and optimal wavelength is about 1054 nanometers.The irradiance of beam of photodisruption that is used for realizing the matrix organization at focused spot place should be bigger than the threshold value of the optical destructive of tissue.Preferably, said irradiance should be not more than 10 times of said threshold value of optical destructive.
The spot size of laser focusing beam should be enough little, to obtain the optical destructive of matrix organization at said focused spot place.Usually, this to require said spot size be about 1.2 microns-10 microns diameter.In addition, said spot configuration is preferably as far as possible near circular.
Flat lens described herein can be glass, quartz glass or medical grade plastics.I measures can distributions
Threshold value described herein can flow be a kind of device that is used to measure the ability distributions.When the principle of operation is based on the optical destructive sample, produce plasma light, in certain embodiments, this sample is a quartz glass plate.Laser beam focuses in the said major part, to avoid the influence from the surface.In given duration of pulse, the optical destructive of material depends on and is defined as the per unit area energy---the threshold value that can flow.The aggressive plasma that in the optical destructive process, produces is sent visible light.Intensity depends on the ability flow valuve greater than threshold value.If the spot size of beam is constant, the amount of the light that then sends depends on energy.In the scope of little Jiao of 1-3 (the typical energy scope that is used to perform the operation), dependence is linear.Plasma light and energy maybe can flow proportional.Signal is collected by photo-detector.In reality, said signal is collected by following mode: scanner is being positioned at scanning beam on the focal plane of said sample.To each point, the position of the said beam of computer recording on the X/Y plane reaches the plasma light intensity of measuring with built-in camera.Said beam moves on said predetermined pattern, and the plasma light in said focal plane distributes by record.Because said energy is constant,, the variation of plasma light intensity causes so being changed by spot size.Image stores in the computing machine to be used for comparison.
The II calibration is said can rheologyization
For example, in certain embodiments, the imagination user can select the signal level on the ability distributions image (reference), can distributions image ability distributions on every side to minimize.During this process on each coordinate points on the X/Y plane, computing machine compares reference value and real signal value.Depend on the symbol (that is, plus or minus) of difference and the amplitude of difference, this energy is increased or is reduced, to minimize said ability distributions.Real-time energy adjustment is accomplished by electric light (EO) modulator.Light transmission through said EO modulator is managed by computer-controlled feedback voltage.Those skilled in the art are familiar with being used for the feedback control strategies of EO modulator.Place under two situation between the cross polarization light at bubble Ke Ersi box (Pockels cell), the light intensity through electrooptic modulator transmission by E Out = E In Sin 2 ( v π 2 V λ / 2 ) Provide, V is the voltage that is applied here, V λ/2Be half-wave voltage, E InAnd E OutBe the intensity of input and output place of said modulator.Through applying V from computing machine Offset=V λ/2/ 2 dc offset voltage is chosen as 50% with the initial transmission rate of modulator.In from 30% to 70% transfer rate scope, the dependence of voltage is approached linearity.Use the linear amplifier of high voltage that feedback is provided, and control the transmission of said modulator.The block scheme of feedback loop and detailed illustrating in Fig. 6 A and 6B thereof.V InBe the voltage of the transmission of the said modulator of control that produces by computing machine.Depend on V In-V OutSymbol and amplitude, as far as each pulse, the aggregate transfer rate of said modulator can change between 30-70%, thus control in the said focal plane said can stream.
In a preferred embodiment, the present invention relates to be used in the laser instrument in laser visual acuity corrective surgery field.Yet scope of the present invention is not limited thereto.Expectation can be used for said method and apparatus of the present invention other field, on focal plane or laser beam spot, has uniform ability distributions in these field desired.
Noted earlier characteristic of the present invention and technical advantage having been done quite widely summarized, and purpose is that thereafter detailed description of the present invention can be understood well.Supplementary features of the present invention and advantage will be described hereinafter, and it has formed the theme of claim of the present invention.Should be understood that disclosed notion and certain embodiments can easily be revised or basis that design realizes other structure of identical purpose of the present invention with acting on.It should further be appreciated that this structure that is equal to does not deviate from the invention of in accessory claim, setting forth mutually.From following description, and combine accompanying drawing to consider to understand the novel feature that is considered to the present invention's difference better, and about its tissue and method of operating, together with further target and advantage.Yet in order more to be expressly understood, each figure only for explanation and purpose of description provide, does not think the qualification that the present invention is limited.
Although at length the present invention and its advantage are described, yet should be appreciated that and do not departing under the situation of the present invention that is defined by the following claims,, substitute and conversion can carry out various variations.And, the specific embodiment of the process that the application's scope is not limited to describe in this instructions, machine, manufacturing, material composition, device, method and step.Can easily understand from said disclosure; Can use present existence, or the roughly the same function of the later corresponding embodiment that can realize that literary composition therewith describes leaved for development or obtain roughly the same result's process, machine, manufacturing, material composition, device, method or step.Correspondingly, appended claim is intended to such process, machine, manufacturing, material composition, device, method or step are included within its scope.

Claims (32)

1. laser beam energy correction method, it is used for proofreading and correct the ability distributions that spreads all over a said laser beam on the predetermined pattern to target sample, and said bearing calibration may further comprise the steps:
Confirm to spread all over the said ability distributions of the said laser beam energy on the focal plane in the said target sample; With
Based on said ability distributions, calibrate the said laser beam energy that is used for said predetermined pattern through revising said laser beam energy.
2. method according to claim 1, wherein said definite said can distributions may further comprise the steps:
Focus on said laser beam and arrive said focal plane through eyeglass;
The said laser beam of pulse transmission makes it pass through said eyeglass and arrives on the said focal plane; With
Measurement spreads all over the said ability distributions on the said focal plane;
Said focal plane said can distributions be stored in the computer memory.
3. method according to claim 2 further comprises and repeats said focusing, pulse transmission, measurement and storing step.
4. method according to claim 2 wherein can flow sensitive material and be positioned at said focal plane.
5. method according to claim 2, wherein measurement ability distributions comprises uses the photo-detector signal acquisition.
6. method according to claim 5, wherein said signal comprises plasma light.
7. method according to claim 2 is wherein measured and can distributions be comprised that the said of a plurality of coordinate points of measurement on said focal plane can stream.
8. method according to claim 7, wherein said a plurality of coordinate points comprise at least 1000 points.
9. method according to claim 2, wherein said pulse transmission comprises constant energy.
10. method according to claim 2, wherein said pulse transmission comprise at least 1000 pulses of per second.
11. method according to claim 2; Wherein the calibration said laser beam energy that is used for said predetermined pattern comprises from said computer memory and fetches ability the distributions on the said focal plane of spreading all over of said storage, and the said laser beam energy that is modified in the interior a single point of said predetermined pattern.
12. method according to claim 11, wherein calibration comprises that ability distributions and reference value with the each point in said focal plane of said storage compare.
13. method according to claim 1, wherein the calibration said laser beam energy that is used for said predetermined pattern comprise minimize spread all on the said predetermined pattern can rheologyization.
14. method according to claim 1 is wherein calibrated the said laser beam energy that is used for said predetermined pattern and is comprised the energy output of controlling said laser beam through feedback control strategies.
15. method according to claim 1, wherein said focal plane comprise a roughly flat surface.
16. method according to claim 1, wherein predetermined pattern comprises spiral.
17. one kind is used to carry out the device of method according to claim 1, and comprise lasing light emitter, focusing, electrooptic modulator, be used for the computer-controlled driver of said electrooptic modulator, and feedback mechanism.
18. a laser beam energy correction method, it is used to proofread and correct the ability distributions of the said laser beam that spreads all over the predetermined pattern in the target sample, and said bearing calibration may further comprise the steps:
Calibration spreads all over the said laser beam energy on the said predetermined pattern;
Focus on said laser beam in said target sample; With
The laser beam of pulse transmission through overregulating makes it spread all over the said predetermined pattern in the said target sample;
Wherein calibration spreads all over said laser beam energy on the said predetermined pattern and comprises from computer memory and fetch spreading all over ability the distributions on the said predetermined pattern and being modified in the said laser beam energy on the interior a single point of said predetermined pattern of being stored.
19. method according to claim 18, wherein said calibration may further comprise the steps:
Focus on said laser beam and arrive the said predetermined pattern in the said target sample through eyeglass;
The said laser beam of pulse transmission makes it pass through said eyeglass and arrives on the said predetermined pattern in the said target sample;
Measurement spreads all over the said ability distributions on the said predetermined pattern in the said target sample; With
Measured ability distributions is stored in the into said computer memory.
20. method according to claim 19 further comprises and repeats said focusing, pulse transmission, measurement and storing step.
21. method according to claim 19, wherein measurement ability distributions comprises uses the photo-detector signal acquisition.
22. method according to claim 21, wherein said signal comprises plasma light.
23. method according to claim 19 is wherein measured and can distributions be comprised that measuring the said of a plurality of along of spreading all over said predetermined pattern can flow.
24. method according to claim 23, wherein said a plurality of focuses comprise at least 1000 focuses.
25. method according to claim 19, wherein said pulse transmission comprises constant energy.
26. method according to claim 19, wherein said pulse transmission comprise at least 10,000 pulse of per second.
27. method according to claim 19, wherein calibration spread all over said laser beam energy on the said predetermined pattern comprise minimize spread all on the said predetermined pattern can rheologyization.
28. method according to claim 19 is wherein calibrated the said laser beam energy that spreads all on the said predetermined pattern and is comprised the energy output of controlling said laser beam through feedback control strategies.
29. method according to claim 19, wherein said eyeglass comprise glass lens or medical grade plastic lens.
30. method according to claim 19, wherein said target sample comprises the threshold energy flow.
31. one kind can be flowed modular station; Comprise lasing light emitter, focusing, electrooptic modulator, be used for the computer-controlled driver of said electrooptic modulator, wherein said computer-controlled driver comprises and is used for the device that method calibration according to claim 1 can distributions.
32. device according to claim 31 further comprises feedback mechanism.
CN2005800276434A 2004-08-17 2005-08-17 Apparatus and method for correction of abberations in laser system optics Expired - Fee Related CN101010568B (en)

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