CN100571752C - The compound Chinese medicinal preparation of treatment rhinitis - Google Patents

Abstract

The invention discloses a kind of compound Chinese medicinal preparation for the treatment of rhinitis, said preparation is made up of 14 flavor raw material of Chinese medicine such as Fructus Xanthii, Flos Magnoliae, the Radix Angelicae Dahuricae, Flos Chrysanthemi Indici, Fructus Schisandrae Chinensis, Herba Schizonepetae, Radix Platycodonis, Radix Saposhnikoviae, Radix Glycyrrhizae, Cortex Phellodendri, the Rhizoma Anemarrhenae, Fructus Forsythiae, Herba Ephedrae and Herba Asari.Show that through clinical efficacy and safety evaluatio it is safe and effective to the treatment acute and chronic rhinitis.The invention provides preparation method.

Description

The compound Chinese medicinal preparation of treatment rhinitis

Technical field:

The present invention relates to Chinese medicine preparation, be specifically related to a kind of compound preparation for the treatment of rhinitis and preparation method thereof.

Background technology:

Rhinitis is that a kind of commonly encountered diseases, frequently-occurring disease are again difficult disease, because the idea of common customs thinks that rhinitis does not include disease and delay treatment.Medical circle again because of its sick little nobody be ready further investigation so that influence people's health level.Yet nose is the important door of respiratory system, and the people can not cease breathing a moment, and closely bound up with nature.The normal phase suffers from rhinitis and also can cause or increase the weight of systemic disease, has brought worry to people, tends to disturb people's orthobiosis, and especially when rhinitis is shown effect, the symptom of generation can make the people feel uneasy even when eating and sleeping, thereby is the problem that people study for the treatment of rhinitis.

Treatment of rhinitis medicine commonly used at present is many based on chemicals, as: subtract towards blood agent, glucocorticoid hormones nasal drop, spray etc., but these medicines are controlled table often, can not solve its root problem, and can cause nose, throat's drying, stimulation, the nasal cavity capillary fragility causes that nasal cavity is often hemorrhage, even medicamentous rhinitis occurs.Therefore, seek to control double the effecting a permanent cure of table, the Chinese medicine that table is originally taken into account has become the research topic of paying close attention to, pure Chinese medicinal preparation or the bonded rhinitis medicines of Chinese medicine and western medicine of some treatment rhinitis also arise at the historic moment, but the application of these medicines or effect are undesirable or chemical drugs wherein causes the side effect of general.Therefore, seeking more, the rational and effective Chinese medicine preparation is the direction with research of Practical significance.

Summary of the invention:

The technical problem to be solved in the present invention is to overcome above-mentioned weak point, research design a kind of more effective, almost do not have a Chinese medicine preparation of the secondary treatment rhinitis of doing.

The invention provides a kind of compound Chinese medicinal preparation for the treatment of rhinitis.

Each raw material of Chinese medicine of compound Chinese medicinal preparation of the present invention is pressed column weight amount per distribution ratio:

Fructus Xanthii 3.9%～74.7%, Flos Magnoliae 0.4%～7.5%, the Radix Angelicae Dahuricae 0.6%～11.2%, Flos Chrysanthemi Indici 0.4%～7.5%, Fructus Schisandrae Chinensis 0.4%～7.5%, Herba Schizonepetae 0.4%～7.5%, Radix Platycodonis 0.6%～11.2%, Radix Saposhnikoviae 0.4%～7.5%, Radix Glycyrrhizae 0.8%～14.9%, Cortex Phellodendri 0.6%～11.2%, the Rhizoma Anemarrhenae 0.4%～7.5%, Fructus Forsythiae 0.8%～14.9%, Herba Ephedrae 0.2%～3.7%, Herba Asari 0.2%～3.7%.

This compound recipe is that the card that wind attacking the lung, wind heat are accumulate the lung criminal of causing nasal cavity is established.The card of nasal cavity, parameter is more, and acute and chronic rhinitis is cold nasal obstruction, stuffy nose.Diseased region is based on nasal cavity, Sui's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases " volume two " wind heat time " are said " as if space between skin and muscles void; then the gas of wind heat is hindered fur earlier; be into lung also; its shape is shivered with cold people's aversion to wind, and order is desired to take off, and tears saliva goes out ... seven or eight little has bluish yellow pus tears such as bullet big; go out in mouth and nose ... ", point out the pathological process of acute rhinitis; Gold Liu's interchannel " element asks that former sick formula six gas of arcane truth are the febrile disease class " points out that first " stuffy nose is stopped up, and plug also.The true Fen swelling of the owner of the house where a fire started is so true Fen then stops up also in the bright nose of hot exogenous YANG pathogen ... the lid yang-energy is contained in last, and upper orifices tonneau and occlusion of the lower orifices person lie on one's side then, call about the bright arteries and veins of sun and intersect, and left arteries and veins is annotated in right key, right arteries and veins is annotated in left key, so wind heat pent-up, the anti-plug of the sick relatively then right key in a left side also." described about the mechanism of nasal obstruction alternately; Deity joint vegetarian is said at its " collection of experiences of famous physicians in the Ming Dynasty " volume three: " the nasal obstruction anosmia, or but meet cold month many plugs, or the just plug that takes a little cold is not reported the person frequently ... this is that lung meridian have pathogenic fire, fire stagnation is very then gained heat happily and is disliked and see coldly, so meet cold just plug, chance is felt and just being sent out also." illustrated the cause of disease of chronic rhinitis.

Wind and cold is violated lung, strongly fragrant and heat-transformation, or wind heat attacks lung, on invade women's head-ornaments, stuffy nose is so see nasal obstruction, flow turbid tears, headache; The volt fire pents up in lung, and evil poison moves in the nose key, visible nose gas heat, nasal mucosa redness, the scorching hot dry sensation of intranasal; So QI and blood stasis nose key is concha nasalis inferior swelling; Impairment of purifying and descending function of the lung, lung Tianjinization is turbid to be harmonious with pathogenic heat, so see that tears are sticking yellow; Accumulate in the pathogenic heat, can accompany diseases such as red tongue, yellow fur, rolling pulse or number simultaneously.It is sensible that this controls the lung qi dispersing that should dispel the wind, the heat-clearing and toxic substances removing evacuation of pus.

This compound recipe looses with sufferings such as Fructus Xanthii, Radix Saposhnikoviaes and dispels the wind, the product of awakening consciousness, and clearing the nasal passage, dispelling wind evil, the sharp head uses Fructus Forsythiae, Flos Chrysanthemi Indici heat-clearing and toxic substances removing again, removes intrinsic heat in the heart, monarch drug in the side of being all; Help Fructus Xanthii, Radix Saposhnikoviae lung qi dispersing to dispel the wind with Flos Magnoliae, Herba Ephedrae, Herba Schizonepetae, the open hole powder heresy, again with Herba Asari, the Radix Angelicae Dahuricae, Radix Platycodonis lung qi dispersing promoting the circulation of QI, detumescence and apocenosis, clear sharp women's head-ornaments, evacuation of pus tears, only headache, auxiliary jointly monarch drug is as ministerial drug; With Cortex Phellodendri, the Rhizoma Anemarrhenae, clearing heat and moistening dryness, anti-kidney yin is thanks to exhausted, hyperactivity of deficient fire, and with the property of Fructus Schisandrae Chinensis convergence, Xuan Zhongyou holds back, and in loosing receipts is arranged, and a surnames such as anti-Herba Ephedrae are logical too, can be eliminating evil and just do not hinder, be adjuvant drug altogether; The Radix Glycyrrhizae heat-clearing and toxic substances removing, it is messenger drug for a coordinating the actions of various ingredients in a prescription.Full side's compatibility rule of treatment is clear and definite, and medication attack and defense is had both, the effect of play altogether that lung qi dispersing dispels the wind, understand things pain-stopping, heat-clearing and toxic substances removing, evacuation of pus ending tears.

Another object of the present invention has provided a kind of preparation method for the treatment of the rhinitis compound Chinese medicinal preparation.

The inventive method comprises the following steps:

(1) extracts

(1) gets Herba Ephedrae, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, be ground into coarse powder, cross 10 mesh sieves with pulverizer, mix homogeneously, by weight/volume ratio, be mixed with 60% ethanol that adds 1 times of amount earlier, in jar moistening 4 hours, 60% alcohol dipping of 4 times of amounts of reuse 24 hours was carried out percolation, collect percolate, medicinal residues add the washing of 2 times of amount warm water once, filter, washing liquid and percolate merge, ethanol is reclaimed in the sedimentation filtering, and the ratio that is concentrated into medical material and medicine liquid volume is that 1.7g: 1ml gets A liquid;

(2) get Flos Chrysanthemi Indici, Herba Asari, Herba Schizonepetae employing vapor distillation extraction method extraction volatile oil, collect miscella; Distillate device is in addition deposited, and medicinal residues decoct with water twice: by weight/volume ratio, the decocting that adds 5 times of amounts for the first time boiled 1.5 hours; The decocting that adds for the second time 5 times of amounts boiled 1 hour, and centrifugal filtration merges distillate and decoction liquor, concentrates, and gets B liquid;

(3) Fructus Xanthii, Radix Saposhnikoviae, Fructus Forsythiae, Radix Glycyrrhizae and Cortex Phellodendri (total amount 18%), by weight/volume ratio, add for the first time 8 times of amounts water, add the water of 6 times of amounts for the second time, decoct with water twice respectively, each two hours, centrifugal filtration concentrated, C liquid;

(4) get above-mentioned A, B, C liquid and merge, the ratio that continues to be concentrated into medical material and medicine liquid volume is 7g: 1ml, and relative density 1.20～1.26 (double dilution method survey) promptly gets extractum;

(5) get Flos Magnoliae and adopt the vapor distillation extraction method to extract volatile oil, collect Flos Magnoliae oil; Distillate device is in addition deposited, and medicinal residues decoct with water twice: by weight/volume ratio, add 6 times of water gagings for the first time and decocted 1.5 hours; The decocting that adds for the second time 5 times of amounts boiled 2 hours, and centrifugal filtration merges distillate and decoction liquor, and being concentrated into relative density is 1.20～1.24 (double dilution method surveys), and spray drying gets the Flos Magnoliae powder;

(6) get Cortex Phellodendri (total amount 82%), Radix Platycodonis, the Radix Angelicae Dahuricae, Flos Magnoliae powder and pulverize and mix,, add the fine powder that the calcium carbonate of 21% sucrose and 21% is pulverized, cross 100 mesh sieves, put that mix homogeneously gets fine powder in the mixer again by the crushed mixture total amount;

(3) sterilization

Step (6) fine powder is packed in the clean cloth bag, use ethylene oxide sterilizing;

(4) preparation granule

Get step (three) sterilization back fine powder and put in the granulator, other get step (4) extractum in 10: 1 ratio dilute with waters as binding agent, do timing by the granule total amount, add 1% magnesium stearate, spray into the miscella of 0.15% Flos Magnoliae oil and 0.05%, prepare granule;

(5) make preparation

The granule and the pharmaceutic adjuvant of step (four) are made preparation.

Compound Chinese medicinal preparation of the present invention can be made oral tablet, capsule, oral liquid, granule or powder etc. according to a conventional method with pharmaceutic adjuvant.

The compound Chinese medicinal preparation that the present invention treats rhinitis has the effect of the lung qi dispersing of dispeling the wind, sensible and heat-clearing and toxic substances removing, and is as follows through clinical efficacy and safety evaluatio result:

One, case source: all case derives from HuaZhong Science University, TongJi medical school, TongJi Hospital, Wuhan No.4 Hospital and the hospital of traditional Chinese hospital, Wuhan City etc.Hospital's department of Chinese medicine, department of otorhinolaryngology outpatient service and inpatient are according to Chinese medical discrimination diagnostic criteria and the Western medicine diagnose standard in " new Chinese medicine is treated the clinical research guideline of acute and chronic nasal sinusitis ".Selected observation case all meets above-mentioned diagnostic criteria, the age: 18-65 is between year.

Two, physical data: this group case has diseases such as nasal membrane hyperemia, concha nasalis swelling (plumpness) and sticking purulent secretion through the department of otorhinolaryngology inspection, meets acute and chronic rhinitis or acute and chronic nasal sinusitis diagnosis person.Meet simultaneously Chinese medical discrimination belong to acute nasal sinusitis 1. exopathogen violate the lung card (the sticking white amount of nasal mucus be many, makes hyposmia during nasal obstruction, the turbinate mucosa redness, forehead or cheekbone portion pain, fever with chills, the cough dry pharynx, red tongue, white and thin fur, floating pulse) 2. the red-hot card of lung meridian (the thick Huang of nasal mucus is difficult for blowing out, and turbinate mucosa is red red, the neck distending pain, it is obstructed to have a stuffy nose, and thirsty, cough expectorant Huang generates heat, red tongue is red, yellow fur, full and large pulse and count); The dialectical standard of chronic sinusitis 1. the hot and suffocating card of gallbladder internal organs (rhinorrhea with yellow turbid discharge, thickness such as pus continue not heal, the nasal obstruction, olfactory disorder, headache and dizzy, the turbinate mucosa redness, bitter taste in the mouth and dry throat, dizzy vexed, Hiccough and deaf, red tongue, yellow fur, wiry and frequent pulse.) 2. asthenia of pulmonosplenic qi card (sticking Bai Erliang is many for nasal mucus, and it is light or heavy have a stuffy nose, air-cooled whenever increasing the weight of, olfactory disorder, turbinate mucosa is light red, swelling, nose heave giddy, the cough thin sputum, the lazyness of breathing hard is sayed, lack of appetite abdominal distention, light red tongue is a little less than the white and thin fur, moderate pulse).

Observed patient is divided into two groups at random: treatment group (rhinitis tablet group) 304 examples, matched group (HUODAN WAN group) 100 examples.Two groups of cases are learned by statistics and are handled equal no significant difference at sex, age, the course of disease, the sick aspects such as distribution and Chinese medical discrimination typing of planting, and comparability (seeing Table 1-3) is arranged

Table 1 liang group sex, mean age, average course of disease situation are relatively

Annotate: compare P between group _All＞0.05

The table 2 liang sick distribution situation of planting of group case doctor trained in Western medicine compares

Annotate: compare P between group _AllThe sick no significance difference that distributes of planting between＞0.05, two groups.

Table 3 liang group case Chinese medical discrimination typing distribution situation is (X relatively ²)

Annotate: compare P between group _AllTraditional Chinese medical science typing distribution-free difference between＞0.05, two groups.

Three, case choice criteria

(1) diagnostic criteria

1, Western medicine diagnose standard

(1) diagnostic criteria of acute sinusitis

1. acute rhinitis, influenza or acute infectious diseases history are arranged;

2. symptoms such as general malaise, joint aches, lassitude, fever with chills are arranged;

3. nasal obstruction, hyposmia, intranasal has a large amount of sticking purulences or purulent secretions, and headache can appear at forehead, glabella or occipitalia, hole chamber local pain;

4. nasal cavity inspection: nasal mucosa hyperemia, the concha nasalis enlargement, middle nasal meatus and olfactory cleft have purulent secretion to overflow, and there is tenderness in the nasal sinuses district;

5. X ray examination: be inflammatory and change sign;

6. lab testing: total white blood cells and neutrophilic granulocyte number increase.

(2) diagnostic criteria of chronic sinusitis

The scorching history of repeated attack of acute nose (hole) is 1. arranged;

2. have a stuffy nose for a long time, sticking pus of stream or pus tears, headache and dizziness, absent minded, hyposmia or disappearance;

3. nasal cavity inspection: nasal mucosa swelling or plumpness, middle nasal concha enlargement or polypoid become, and sticking pus tears are arranged in the corresponding nasal meatus of sick hole;

4. X ray examination: the hole chamber is fuzzy, muddiness, increase in density, pachymucosa or liquid level is arranged;

5. puncture or catheters irrigation have the pus overflow.

2, Chinese medical discrimination standard

(1) anxious nasal sinusitis is dialectical

1. exopathogen is violated the lung card

The sticking white amount of nasal mucus is many, makes hyposmia, turbinate mucosa redness, forehead or cheekbone portion pain, fever with chills, cough dry pharynx, red tongue, white and thin fur, floating pulse during nasal obstruction.

2. the red-hot card of lung meridian

The thick Huang of nasal mucus is difficult for blowing out, and turbinate mucosa is red red, the neck distending pain, and it is obstructed to have a stuffy nose, thirsty, the cough expectorant Huang that generates heat, red tongue is red, yellow fur, full and large pulse and counting.

(2) the slow dialectical standard of nasal sinusitis

1. the hot and suffocating card of gallbladder internal organs

Rhinorrhea with yellow turbid discharge, thickness such as pus continue not heal, nasal obstruction, olfactory disorder, headache and dizzy, the turbinate mucosa redness, bitter taste in the mouth and dry throat, dizzy vexed, Hiccough and deaf, red tongue, yellow fur, wiry and frequent pulse.

2. asthenia of pulmonosplenic qi is demonstrate,proved

Sticking Bai Erliang is many for nasal mucus, and it is light or heavy to have a stuffy nose, air-cooled whenever increasing the weight of, and olfactory disorder, turbinate mucosa is light red, swelling, nose heave giddy, the cough thin sputum, the lazy speech of breathing hard, lack of appetite abdominal distention, light red tongue, white and thin fur is a little less than the moderate pulse.

3, include the case standard in

Allly meet primary disease diagnostic criteria and Chinese medical discrimination person, can include the test case in.

4, get rid of case standard (comprising inadaptation or rejecting standard)

1. the age is at under-18s or over-65s, gestation or women breast-feeding their children, allergic constitution or to this medicine allergy sufferers;

2. be associated with cardiovascular, cerebrovascular, liver, serious primary disease such as kidney or hemopoietic system, psychotic;

3. nasal polyp, nose malignant tumor patient;

4. do not meet the standard of including in, not medication in accordance with regulations can't be judged curative effect, or data is not congruent affects the treatment or safety judgement person.

Therapeutic Method

One, observation index

(1) safety indexes: routine blood test (RBC, HB, WBC, N), routine urinalysis, stool routine examination, electrocardiogram, liver function (ALT) renal function (BUN, Cr).

(2) health giving quality index: main clinic symptoms and sign: nasal obstruction, flow turbid tears, olfactory disorder, headache (expanding), heating, nasal mucosa swelling, picture of the tongue, pulse condition etc.

(3) X ray examination (according to state of an illness needs to the chronic sinusitis case control).

(4) take medicine the back untoward reaction (gastrointestinal reaction or dermoreaction).

Two, efficacy assessment standard

Be divided into produce effects, standard such as effective and invalid according to " new Chinese medicine is treated the clinical research guideline of acute and chronic nasal sinusitis ".

(1) acute nasal sinusitis curative effect determinate standard

1. produce effects: alleviated 2/3 with interior cardinal symptom in 10 days, most of sign disappears;

2. effective: alleviated 1/3 with interior cardinal symptom in 10 days, the part sign disappears;

3. invalid: medication 10 days does not reach effective standard.

(2) chronic sinusitis curative effect determinate standard

1. produce effects: treat and alleviated 2/3 with interior cardinal symptom and sign in 30 days;

2. effective: as to treat and alleviated 1/3 with interior cardinal symptom and sign in 30 days;

3. invalid: as to treat 30 days, and do not reach effective standard.

(3) symptom and sign light and heavy degree classification

The obvious person of Sx is severe (+++); The obvious person of Sx is a moderate (++); The not obvious person of symptom and sign is slight (+).Treatment back by +++→+, ++ improvement such as → 0 is decided to be II level (produce effects); Treatment back by +++→ ++, ++ →+or+improvement such as → 0 is decided to be I level (effectively); Do not have before the original symptom and sign in treatment back is controlled and change into 0 grade (invalid).

Three, method of administration

Include standard in and reject the Standard Selection case according to case in " new Chinese medicine is treated acute and chronic nasal sinusitis clinical research guideline ", include in and observe inactive earlier other treatment rhinitis medicine of case, be divided into treatment group and matched group at random.

(1) treatment group: 1. be subjected to the reagent thing: rhinitis tablet

Source: join pharmaceutical factory in the Wuhan City

Specification: 0.5 gram/sheet

Lot number: 000601

Preservation condition: sealing, put shady and cool dry place.

2. dosage regimen

Dosage: one time 2,3 times on the one

The course of treatment: acute nasal sinusitis 10 days, chronic sinusitis 30 months

Usage: oral

(2) matched group: 1. be subjected to the reagent thing: HUODAN WAN

Source: Guangzhou Huacheng pharmaceutical plant

Specification: 36 gram/bottles

Lot number: 990205

Preservation condition: sealing, protection against the tide.

2. dosage regimen

Dosage: one time 6 gram, 2 times on the one

The course of treatment: acute nasal sinusitis 10 days, chronic sinusitis 30 months

Usage: oral

Every routine patient all observes safety observation project before and after the treatment, other curative of stopping using during the clinical observation.Patient's further consultation weekly once writes down main clinic symptoms and improves situation and relevant medication untoward reaction, finishes the back check course of treatment about checking index.

Therapeutic outcome

Statistical processing methods: the grade classified data is analyzed with Ridit, enumeration data X ²Check, measurement data is checked with t.

One, two groups of total clinical efficacies relatively

Rhinitis tablet group (treatment group) is improved acute and chronic rhinitis, its produce effects 154 examples of sinusitis, accounts for 50.66%, and effective 115 examples account for 37.78%, and invalid 35 examples occupy 11.51%, and total effective rate is 269 examples, accounts for 88.84%; HUODAN WAN (matched group) should be produce effects 44 examples (44.0%) mutually, effective 40 examples (40%), and invalid 16 examples (16.0%), total effective rate is 84.0%.Two groups are compared no significant difference (P＞0.05), see Table 4

The scorching clinical total effects of table 4 liang group treatment acute and chronic nose (nasal sinuses) is (X relatively ²)

Annotate: two groups are compared P＞0.05.

Two, two groups of main clinic symptoms and the comparative analysis of sign curative effect

After two groups of Drug therapys, have a stuffy nose, flow main clinic symptoms curative effects such as turbid tears, olfactory disorder, headache (expanding) heating nasal mucosa redness and relatively see Table 5

The curative effect that table 5 pair cardinal symptom sign is improved is (X relatively ²)

Annotate: two groups are compared P _All＞0.05, relatively there was no significant difference of two groups of group symptom curative effects is described.

Three, two groups of different TCM Syndrome Type efficacy analysis relatively

Two groups of acute nasal sinusitis exopathogen are violated lung card, the red-hot card of lung meridian and the hot and suffocating card of chronic sinusitis gallbladder internal organs, syndrome of qi deficiency of spleen and lung curative effect and are relatively seen Table 6

The table 6 liang different TCM Syndrome Type curative effects of group are (X relatively ²)

Annotate: two groups are compared P _All＞0.05, relatively there was no significant difference of two groups of medicine pattern of syndrome curative effects is described.

Four, two groups of Chinese medicines are planted curative effect relatively to different noses are sick:

Two groups of observed drug acute rhinitises, sinusitis 10 days.Rhinitis tablet treatment acute rhinitis, sinusitis 10 days were a course of treatment, total effective rate is respectively 100.0% and 92.21%, treatment chronic rhinitis, sinusitis treatment were a course of treatment in 30 days, and total effective rate is respectively 82.67% and 85.71%, does not more all have significant difference (P with matched group _All＞0.05), sees Table 7

The different sick relatively (X of curative effect that plant of table 7 liang group ²)

Annotate: two groups are compared P _All＞0.05, illustrate that two groups of medicines compare there was no significant difference at different nasal disease curative effects.

Five, two groups of treatment front and back X ray examination results relatively

According to state of an illness needs, chronic sinusitis (chronic sinusitis) is made nose X ray examination, the results are shown in Table 8

Nose X ray examination result compares (X before and after the table 8 liang group treatment treatment ²)

Annotate: compare * P before and after the treatment _All＜0.05; * P _All＜0.01

Six, change before and after the safety indexes treatment

All observe routine blood test, routine urinalysis, stool routine examination, hepatic and renal function and Electrocardioscopy before and after two groups of treatments.The results are shown in Table 9, table 10, table 11

Routine blood test result comparison before and after the table 9 liang group treatment (X ± S)

Annotate: two groups are compared * P before and after the treatment _All＜0.05, rhinitis tablet has the WBC of falling and classification effect.

Routine urinalysis, stool routine examination and electrocardiogram result compare (X before and after the table 10 liang group treatment ²)

Annotate: compare P before and after two groups of treatments _All＞0.05, safety indexes there is not influence.

Liver, renal function result (X ± S) relatively before and after the treatment of table 11 liang group

Annotate: compare P before and after two treatments _All＞0.05.

Seven, untoward reaction

Two groups of patients there is no digestive tract irritant reaction and skin allergy symptom in period in a medicine three tame hospitals.Illustrate that rhinitis tablet treatment acute and chronic nose (nasal sinuses) is scorching oral safe and effective.

Conclusion

1, rhinitis tablet treatment acute and chronic rhinitis, sinusitis total effective rate are 88.48%, and obvious effective rate is 50.66%.Matched group (HUODAN WAN) is respectively 84.0% and 44.0%.Learn more by statistics for two groups and handle there was no significant difference P＞0.05.

2, rhinitis tablet is good to the curative effect of improving acute and chronic nose, nasosinusitis main clinic symptoms nasal obstruction, turbid nasal discharge, headache (expanding), hyposmia, heating and sign, nasal mucosa redness etc.Wherein better to the red and swollen curative effect of nasal obstruction, turbid nasal discharge, nasal mucosa, be respectively 93.42%, 90.33% and 91.86%, be excellent than HUODAN WAN.

3, rhinitis tablet to the acute rhinitis curative effect be 100%, the therapeutic effect of sinusitis is 92.21%, is 82.67% to chronic rhinitis, the curative effect of sinusitis is 85.71%, both learn by statistics and handle the no significance difference opposite sex.

4, as seen from Table 6, it is excellent that rhinitis tablet is violated lung card curative effect to the nasal sinusitis exopathogen, reaches 92.22%, relatively poor to slow nasal sinusitis asthenia of pulmonosplenic qi card curative effect, is 82.68% to different TCM Syndrome Type efficacy analysis, but no difference of science of statistics (P＞0.05).

5, to acute and chronic rhinitis, the sinusitis efficacy analysis of Western medicine diagnose, the acute rhinitis curative effect is better than chronic rhinitis, is respectively 100% and 82.67% from table 7 finding rhinitis tablet, but also no difference of science of statistics (P＞0.05).

6, to the influence of X line film making: see from table 8 after 1 month through the rhinitis tablet treatment, X line film making finding is fuzzy to chronic sinusitis, hole film, increase in density and have liquid level all to treat before take an evident turn for the better.

7, to the influence of safety indexes: during the rhinitis tablet treatment blood, urine, stool routine examination, hepatic and renal function and electrocardiogram are not all had influence.

8, period in a medicine does not find that rhinitis tablet has any digestive tract stimulation and skin allergy, illustrates that rhinitis tablet is treated acute and chronic rhinitis, sinusitis is safe and effective.

The specific embodiment:

Example 1: the preparation of rhinitis tablet

Prescription:

Fructus Xanthii 416.0kg Flos Magnoliae 41.6kg Radix Angelicae Dahuricae 62.4kg

Flos Chrysanthemi Indici 41.6kg Fructus Schisandrae Chinensis 41.6kg Herba Schizonepetae 41.6kg

Radix Platycodonis 62.4kg Radix Saposhnikoviae 41.6kg Radix Glycyrrhizae 83.2kg

Cortex Phellodendri 60.3kg Rhizoma Anemarrhenae 41.6kg Fructus Forsythiae 83.2kg

Herba Ephedrae 20.8kg Herba Asari 20.8kg

Preparation

One, extracts

1. get Herba Ephedrae, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, be ground into coarse powder with pulverizer, cross 10 mesh sieves, mix homogeneously is mixed with 60% ethanol that adds 93.6kg earlier, and in jar moistening 4 hours, 60% alcohol dipping of reuse 374.4kg 24 hours was carried out percolation, the collection percolate.Medicinal residues add the washing of 208.0kg warm water once, filter, and washing liquid and percolate merge, and ethanol is reclaimed in the sedimentation filtering, is concentrated into 60.0kg and gets A liquid.

2. get Flos Chrysanthemi Indici, Herba Asari, Herba Schizonepetae employing vapor distillation extraction method extraction volatile oil, collect miscella; Distillate device is in addition deposited, and medicinal residues decoct with water twice: the decocting that adds 5 times of amounts for the first time boiled 1.5 hours; The decocting that adds for the second time 5 times of amounts boiled 1 hour, and centrifugal filtration merges distillate and decoction liquor, is concentrated into 15.0kg, gets B liquid.

3. Fructus Xanthii, Radix Saposhnikoviae, Fructus Forsythiae, Radix Glycyrrhizae and 4.1kg Cortex Phellodendri decoct with water twice respectively, add 8 times of water gagings for the first time, add 6 times of water gagings for the second time, decoct two hours at every turn, centrifugal filtration is concentrated into 130.0kg, C liquid.

4. get above-mentioned A, B, the merging of C liquid, continue to be concentrated into 147.6kg (relative density 1.20～1.26, double dilution method is surveyed), promptly get extractum.

5. get Flos Magnoliae and adopt the vapor distillation extraction method to extract volatile oil, collect Flos Magnoliae oil; Distillate device is in addition deposited, and medicinal residues decoct with water twice: add 6 times of water gagings for the first time and decocted 1.5 hours; Add for the second time 5 times of water gagings and decocted 2 hours, centrifugal filtration merges distillate and decoction liquor, and being concentrated into relative density is 1.20～1.24 (double dilution method surveys), and spray drying gets the Flos Magnoliae powder.

Two, pulverize

Get 56.2kg Cortex Phellodendri, Radix Platycodonis, the Radix Angelicae Dahuricae, Flos Magnoliae powder, sucrose 40kg, calcium carbonate 39kg.Pulverize, cross 100 mesh sieves, put and be mixed into fine powder in the mixer.

Three, sterilization

Fine powder is packed in the clean cloth bag, use ethylene oxide sterilizing.

Four, granulate

Get fine powder and put in the one-step-granulating method, get extractum and granulate as binding agent in 10: 1 ratio dilute with waters, do timing and add the 3.6kg magnesium stearate, spray into Flos Magnoliae oil 540ml and miscella 180ml, tabletting, coating are made finished product.

Example 2: the preparation of rhinitis tablet

Prescription:

Fructus Xanthii 138.6kg Flos Magnoliae 13.9kg Radix Angelicae Dahuricae 20.8kg

Flos Chrysanthemi Indici 13.9kg Fructus Schisandrae Chinensis 13.9kg Herba Schizonepetae 13.9kg

Radix Platycodonis 20.8kg Radix Saposhnikoviae 13.9kg Radix Glycyrrhizae 27.7kg

Cortex Phellodendri 20.1kg Rhizoma Anemarrhenae 13.9kg Fructus Forsythiae 27.7kg

Herba Ephedrae 6.9kg Herba Asari 6.9kg

Preparation: with example 1.

Example 3: the preparation of rhinitis tablet

Prescription:

Fructus Xanthii 3.9kg, Flos Magnoliae 0.4kg, Radix Angelicae Dahuricae 0.6kg, Flos Chrysanthemi Indici 0.4kg, Fructus Schisandrae Chinensis 0.4kg, Herba Schizonepetae 0.4kg, Radix Platycodonis 0.6kg, Radix Saposhnikoviae 0.4kg, Radix Glycyrrhizae 0.8kg, Cortex Phellodendri 0.6kg, Rhizoma Anemarrhenae 0.4kg, Fructus Forsythiae 0.8kg, Herba Ephedrae 0.2kg, Herba Asari 0.2kg.

Preparation: with example 1.

Example 4: the preparation of rhinitis tablet

Prescription:

Fructus Xanthii 74.7kg, Flos Magnoliae 7.5kg, Radix Angelicae Dahuricae 11.2kg, Flos Chrysanthemi Indici 7.5kg, Fructus Schisandrae Chinensis 7.5kg, Herba Schizonepetae 7.5kg, Radix Platycodonis 11.2kg, Radix Saposhnikoviae 7.5kg, Radix Glycyrrhizae 14.9kg, Cortex Phellodendri 11.2kg, Rhizoma Anemarrhenae 7.5kg, Fructus Forsythiae 14.9kg, Herba Ephedrae 3.7kg, Herba Asari 3.7kg.

Preparation: with example 1.

Example 5: the preparation of capsule for treating rhinitis

Prescription:

Fructus Xanthii 416.0kg Flos Magnoliae 41.6kg Radix Angelicae Dahuricae 62.4kg

Flos Chrysanthemi Indici 41.6kg Fructus Schisandrae Chinensis 41.6kg Herba Schizonepetae 41.6kg

Radix Platycodonis 62.4kg Radix Saposhnikoviae 41.6kg Radix Glycyrrhizae 83.2kg

Cortex Phellodendri 60.3kg Rhizoma Anemarrhenae 41.6kg Fructus Forsythiae 83.2kg

Herba Ephedrae 20.8kg Herba Asari 20.8kg

Preparation

One, extracts

1. get Herba Ephedrae, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, be ground into coarse powder with pulverizer, cross 10 mesh sieves, mix homogeneously is mixed with 60% ethanol that adds 93.6kg earlier, and in jar moistening 4 hours, 60% alcohol dipping of reuse 374.4kg 24 hours was carried out percolation, the collection percolate.Medicinal residues add the washing of 208.0kg warm water once, filter, and washing liquid and percolate merge, and ethanol is reclaimed in the sedimentation filtering, is concentrated into 60.0kg.Get A liquid.

2. get Flos Chrysanthemi Indici, Herba Asari, Herba Schizonepetae employing vapor distillation extraction method extraction volatile oil, collect miscella; Distillate device is in addition deposited, and medicinal residues decoct with water twice: add 5 times of water gagings for the first time and decocted 1.5 hours; Add for the second time 5 times of water gagings and decocted 1 hour, centrifugal filtration merges distillate and decoction liquor, is concentrated into 15.0kg, gets B liquid.

3. Fructus Xanthii, Radix Saposhnikoviae, the Cortex Phellodendri of Fructus Forsythiae, Radix Glycyrrhizae, 4.1kg decocts with water twice respectively, adds 8 times of water gagings for the first time, adds 6 times of water gagings for the second time, each two hours, centrifugal filtration was concentrated into 130.0kg, C liquid.

4. get above-mentioned A, B, the merging of C liquid, continue to be concentrated into 147.6kg (relative density 1.20～1.26, double dilution method is surveyed), promptly get extractum.

5. get Flos Magnoliae and adopt the vapor distillation extraction method to extract volatile oil, collect Flos Magnoliae oil; Distillate device is in addition deposited, and medicinal residues decoct with water twice: add 6 times of water gagings for the first time and decocted 1.5 hours; Add for the second time 5 times of water gagings and decocted 2 hours, centrifugal filtration merges distillate and decoction liquor, and being concentrated into relative density is 1.20～1.24 (double dilution method surveys), and spray drying gets the Flos Magnoliae powder.

Two, pulverize

Get 56.2kg Cortex Phellodendri, Radix Platycodonis, the Radix Angelicae Dahuricae, Flos Magnoliae powder, starch 8kg.Pulverize, cross 100 mesh sieves, put and be mixed into fine powder in the mixer.

Three, sterilization

Fine powder is packed in the clean cloth bag, use ethylene oxide sterilizing.

Four, granulation, encapsulated

Get fine powder and put in the one-step-granulating method, get extractum and granulate as binding agent in 10: 1 ratio dilute with waters, drying sprays into Flos Magnoliae oil 540ml and miscella 180ml, incapsulates, and makes finished product.

Example 6: the preparation of capsule for treating rhinitis

Prescription:

Fructus Xanthii 138.6kg Flos Magnoliae 13.9kg Radix Angelicae Dahuricae 20.8kg

Flos Chrysanthemi Indici 13.9kg Fructus Schisandrae Chinensis 13.9kg Herba Schizonepetae 13.9kg

Radix Platycodonis 20.8kg Radix Saposhnikoviae 13.9kg Radix Glycyrrhizae 27.7kg

Cortex Phellodendri 20.1kg Rhizoma Anemarrhenae 13.9kg Fructus Forsythiae 27.7kg

Herba Ephedrae 6.9kg Herba Asari 6.9kg

Preparation: with example 5.

Example 7: the preparation of rhinitis oral liquid

Prescription:

Fructus Xanthii 138.6kg Flos Magnoliae 13.9kg Radix Angelicae Dahuricae 20.8kg

Flos Chrysanthemi Indici 13.9kg Fructus Schisandrae Chinensis 13.9kg Herba Schizonepetae 13.9kg

Radix Platycodonis 20.8kg Radix Saposhnikoviae 13.9kg Radix Glycyrrhizae 27.7kg

Cortex Phellodendri 20.1kg Rhizoma Anemarrhenae 13.9kg Fructus Forsythiae 27.7kg

Herba Ephedrae 6.9kg Herba Asari 6.9kg

Preparation

1. get Herba Ephedrae, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, be ground into coarse powder with pulverizer, cross 10 mesh sieves, mix homogeneously is mixed with 60% ethanol that adds 31.5kg earlier, and in jar moistening 4 hours, 60% alcohol dipping of reuse 125.1kg 24 hours was carried out percolation, the collection percolate.Medicinal residues add the washing of 70.0kg warm water once, filter, and washing liquid and percolate merge, and ethanol is reclaimed in the sedimentation filtering, is concentrated into 200.0kg.Get A liquid.

2. get Flos Chrysanthemi Indici, Herba Asari, Herba Schizonepetae employing vapor distillation extraction method extraction volatile oil, collect miscella; Distillate device is in addition deposited, and medicinal residues decoct with water twice: add 5 times of water gagings for the first time and decocted 1.5 hours; Add for the second time 5 times of water gagings and decocted 1 hour, centrifugal filtration merges distillate and decoction liquor, is concentrated into 50.0kg, gets B liquid.

3. Fructus Xanthii, Radix Saposhnikoviae, Fructus Forsythiae, Radix Glycyrrhizae, Radix Platycodonis, the Radix Angelicae Dahuricae, Cortex Phellodendri decoct with water twice respectively, add 8 times of water gagings for the first time, add 6 times of water gagings for the second time, each two hours, centrifugal filtration was concentrated into 400.0kg, C liquid.

4. get Flos Magnoliae and adopt the vapor distillation extraction method to extract volatile oil, collect Flos Magnoliae oil; Distillate device is in addition deposited, and medicinal residues decoct with water twice: add 6 times of water gagings for the first time and decocted 1.5 hours; Add for the second time 5 times of water gagings and decocted 2 hours, centrifugal filtration merges distillate and decoction liquor, and being concentrated into relative density is 1.20～1.24 (double dilution method surveys), and spray drying gets the Flos Magnoliae powder.

5. get above-mentioned A, B, the merging of C liquid, leave standstill, get supernatant, add Flos Magnoliae powder, 900kg sugarcane candy and 3.6kg sodium benzoate, stirring makes dissolving, boils 30 minutes, and cold back adds Flos Magnoliae oil 180ml and miscella 60ml, mix homogeneously is adjusted volume to 120 ten thousand ml, fill.Make finished product.

Example 8: the preparation of rhinitis oral liquid

Prescription:

Fructus Xanthii 416.0kg Flos Magnoliae 41.6kg Radix Angelicae Dahuricae 62.4kg

Flos Chrysanthemi Indici 41.6kg Fructus Schisandrae Chinensis 41.6kg Herba Schizonepetae 41.6kg

Radix Platycodonis 62.4kg Radix Saposhnikoviae 41.6kg Radix Glycyrrhizae 83.2kg

Cortex Phellodendri 60.3kg Rhizoma Anemarrhenae 41.6kg Fructus Forsythiae 83.2kg

Herba Ephedrae 20.8kg Herba Asari 20.8kg

Preparation: with example 7.

Example 9: the preparation of rhinitis particle agent

Prescription:

Fructus Xanthii 138.6kg Flos Magnoliae 13.9kg Radix Angelicae Dahuricae 20.8kg

Flos Chrysanthemi Indici 13.9kg Fructus Schisandrae Chinensis 13.9kg Herba Schizonepetae 13.9kg

Radix Platycodonis 20.8kg Radix Saposhnikoviae 13.9kg Radix Glycyrrhizae 27.7kg

Cortex Phellodendri 20.1kg Rhizoma Anemarrhenae 13.9kg Fructus Forsythiae 27.7kg

Herba Ephedrae 6.9kg Herba Asari 6.9kg

Preparation

1. get Herba Ephedrae, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, be ground into coarse powder with pulverizer, cross 10 mesh sieves, mix homogeneously is mixed with 60% ethanol that adds 31.5kg earlier, and in jar moistening 4 hours, 60% alcohol dipping of reuse 125.0kg 24 hours was carried out percolation, the collection percolate.Medicinal residues add the washing of 70.0kg warm water once, filter, and washing liquid and percolate merge, and ethanol is reclaimed in the sedimentation filtering, is concentrated into 30.0kg.Get A liquid.

2. get Flos Chrysanthemi Indici, Herba Asari, Herba Schizonepetae employing vapor distillation extraction method extraction volatile oil, collect miscella; Distillate device is in addition deposited, and medicinal residues decoct with water twice: add 5 times of water gagings for the first time and decocted 1.5 hours; Add for the second time 5 times of water gagings and decocted 1 hour, centrifugal filtration merges distillate and decoction liquor, is concentrated into 10.0kg, gets B liquid.

3. Fructus Xanthii, Radix Saposhnikoviae, Fructus Forsythiae, Radix Glycyrrhizae, Radix Platycodonis, the Radix Angelicae Dahuricae, Cortex Phellodendri decoct with water twice respectively, add 8 times of water gagings for the first time, add 6 times of water gagings for the second time, each two hours, centrifugal filtration was concentrated into 60.0kg, C liquid.

4. get Flos Magnoliae and adopt the vapor distillation extraction method to extract volatile oil, collect Flos Magnoliae oil; Distillate device is in addition deposited, and medicinal residues decoct with water twice: add 6 times of water gagings for the first time and decocted 1.5 hours; Add for the second time 5 times of water gagings and decocted 2 hours, centrifugal filtration merges distillate and decoction liquor, and being concentrated into relative density is 1.20～1.24 (double dilution method surveys), and spray drying gets the Flos Magnoliae powder.

4. get above-mentioned A, B, the merging of C liquid, continue to be concentrated into 85.2kg (relative density 1.30～1.32, double dilution method is surveyed), promptly get extractum.

Three, granulate

Flos Magnoliae powder, extractum, by the extractum amount, add the Icing Sugar that 5-6 doubly measures and granulate, drying sprays into Flos Magnoliae oil 180ml and miscella 60ml, makes finished product.

Example 10: the preparation of rhinitis particle agent

Prescription:

Fructus Xanthii 416.0kg Flos Magnoliae 41.6kg Radix Angelicae Dahuricae 62.4kg

Flos Chrysanthemi Indici 41.6kg Fructus Schisandrae Chinensis 41.6kg Herba Schizonepetae 41.6kg

Radix Platycodonis 62.4kg Radix Saposhnikoviae 41.6kg Radix Glycyrrhizae 83.2kg

Cortex Phellodendri 60.3kg Rhizoma Anemarrhenae 41.6kg Fructus Forsythiae 83.2kg

Herba Ephedrae 20.8kg Herba Asari 20.8kg

Preparation: with example 9.

Example 11: the preparation of rhinitis powder

Prescription:

Fructus Xanthii 416.0kg Flos Magnoliae 41.6kg Radix Angelicae Dahuricae 62.4kg

Flos Chrysanthemi Indici 41.6kg Fructus Schisandrae Chinensis 41.6kg Herba Schizonepetae 41.6kg

Radix Platycodonis 62.4kg Radix Saposhnikoviae 41.6kg Radix Glycyrrhizae 83.2kg

Cortex Phellodendri 60.3kg Rhizoma Anemarrhenae 41.6kg Fructus Forsythiae 83.2kg

Herba Ephedrae 20.8kg Herba Asari 20.8kg

Preparation

1, Fructus Xanthii, Radix Glycyrrhizae decoct with water twice, the water that once adds 8 times of amounts, add for the second time the water of 6 times of amounts, each two hours, centrifugal filtration, being concentrated into relative density is 1.20～1.24 (double dilution method surveys);

2, after surplus medicated powder is broken into coarse powder, with above thick paste mixing, drying,

3, be ground into fine powder, sieve, finished product is made in sterilization back packing.

Example 12: the preparation of rhinitis powder

Prescription:

Fructus Xanthii 138.6kg Flos Magnoliae 13.9kg Radix Angelicae Dahuricae 20.8kg

Flos Chrysanthemi Indici 13.9kg Fructus Schisandrae Chinensis 13.9kg Herba Schizonepetae 13.9kg

Radix Platycodonis 20.8kg Radix Saposhnikoviae 13.9kg Radix Glycyrrhizae 27.7kg

Cortex Phellodendri 20.1kg Rhizoma Anemarrhenae 13.9kg Fructus Forsythiae 27.7kg

Herba Ephedrae 6.9kg Herba Asari 6.9kg

Preparation: with example 11.

Claims (3)

1, a kind of compound Chinese medicinal preparation for the treatment of rhinitis is characterized in that pressing column weight amount per distribution ratio by each raw material of Chinese medicine makes:

Fructus Xanthii 3.9%～74.7%, Flos Magnoliae 0.4%～7.5%, the Radix Angelicae Dahuricae 0.6%～11.2%, Flos Chrysanthemi Indici 0.4%～7.5%, Fructus Schisandrae Chinensis 0.4%～7.5%, Herba Schizonepetae 0.4%～7.5%, Radix Platycodonis 0.6%～11.2%, Radix Saposhnikoviae 0.4%～7.5%, Radix Glycyrrhizae 0.8%～14.9%, Cortex Phellodendri 0.6%～11.2%, the Rhizoma Anemarrhenae 0.4%～7.5%, Fructus Forsythiae 0.8%～14.9%, Herba Ephedrae 0.2%～3.7%, Herba Asari 0.2%～3.7%.

2, a kind of preparation method of treatment rhinitis compound Chinese medicinal preparation as claimed in claim 1 is characterized in that this method comprises the following steps:

(1) extracts

(1) gets Herba Ephedrae, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, be ground into coarse powder, cross 10 mesh sieves with pulverizer, mix homogeneously, by weight/volume ratio, be mixed with 60% ethanol that adds 1 times of amount earlier, in jar moistening 4 hours, 60% alcohol dipping of 4 times of amounts of reuse 24 hours was carried out percolation, collect percolate, medicinal residues add the washing of 2 times of amount warm water once, filter, washing liquid and percolate merge, ethanol is reclaimed in the sedimentation filtering, and the ratio that is concentrated into medical material and medicine liquid volume is that 1.7g:1ml gets A liquid;

(2) get Flos Chrysanthemi Indici, Herba Asari, Herba Schizonepetae employing vapor distillation extraction method extraction volatile oil, collect miscella; Distillate device is in addition deposited, and medicinal residues decoct with water twice: by weight/volume ratio, the decocting that adds 5 times of amounts for the first time boiled 1.5 hours; The decocting that adds for the second time 5 times of amounts boiled 1 hour, and centrifugal filtration merges distillate and decoction liquor, concentrates, and gets B liquid;

(3) 18% raw material of Fructus Xanthii, Radix Saposhnikoviae, Fructus Forsythiae, Radix Glycyrrhizae and Cortex Phellodendri total amount, by weight/volume ratio, add for the first time 8 times of amounts water, add the water of 6 times of amounts for the second time, decoct with water twice respectively, each two hours, centrifugal filtration concentrated, C liquid;

(4) get above-mentioned A, B, C liquid and merge, the ratio that continues to be concentrated into medical material and medicine liquid volume is 7g: 1ml, and relative density 1.20～1.26 promptly gets extractum;

(5) get Flos Magnoliae and adopt the vapor distillation extraction method to extract volatile oil, collect Flos Magnoliae oil; Distillate device is in addition deposited, and medicinal residues decoct with water twice: by weight/volume ratio, add 6 times of water gagings for the first time and decocted 1.5 hours; The decocting that adds for the second time 5 times of amounts boiled 2 hours, and centrifugal filtration merges distillate and decoction liquor, and being concentrated into relative density is 1.20～1.24, and spray drying gets the Flos Magnoliae powder;

(6) get 82% raw material, Radix Platycodonis, the Radix Angelicae Dahuricae, the Flos Magnoliae powder of Cortex Phellodendri total amount, pulverize and mix,, add the fine powder that the calcium carbonate of 21% sucrose and 21% is pulverized, mix the back and cross 100 mesh sieves, put that mix homogeneously gets fine powder in the mixer again by the crushed mixture total amount;

(3) sterilization

Step (6) fine powder is packed in the clean cloth bag, use ethylene oxide sterilizing;

(4) preparation granule

Get step (three) sterilization back fine powder and put in the granulator, other get step (4) extractum in 10: 1 ratio dilute with waters as binding agent, do timing by the granule total amount, add 1% magnesium stearate, spray into the miscella of 0.15% Flos Magnoliae oil and 0.05%, prepare granule;

(5) make preparation

The granule and the pharmaceutic adjuvant of step (four) are made preparation.

3,, it is characterized in that described compound Chinese medicinal preparation is oral tablet, capsule, powder, granule or oral liquid according to the described a kind of compound Chinese medicinal preparation for the treatment of rhinitis of claim 1.