Summary of the invention
The objective of the invention is to: provide a kind of medical protein fiber, to overcome the existing big defective of medicinal fabric smell.
A further object of the present invention provides a kind of method for preparing medical protein fiber, and makes full use of existing equipment as much as possible.
Another purpose of the present invention provides a kind of using method of medical protein fiber.
The object of the invention can be achieved through the following technical solutions: a kind of medical protein fiber of preventing and treating the proliferation of mammary gland, contain protein, high molecular polymer, prevent and treat the medicine and the drug transdermal sorbefacient of the proliferation of mammary gland, wherein, described protein is a kind of or its composition in phytoprotein, the animal protein; Described high molecular polymer is one or more in polyvinyl alcohol, polyacrylonitrile, third rare nitrile, cellulose, the vinyl acetate; Described medicine is included as a kind of or its composition in tamoxifen (TAM), isoflavones (isoflavones), Bromocriptine (bromocriPtine) and the danazol (danazol); Described drug transdermal sorbefacient is a kind of or its composition in azone, oleic acid, N-N-methyl-2-2-pyrrolidone N-, propylene glycol, the borneol; Protein accounts for A part of total weight of fiber, and high molecular polymer accounts for B part of total weight of fiber, and medicine accounts for C part of total weight of fiber, and the drug transdermal sorbefacient accounts for D part of total weight of fiber, then: 1≤A≤80,1≤B≤80,0<C≤20,0<D≤10.
On the such scheme basis, described protein is animal protein, and animal protein accounts for A part of total weight of fiber, 1≤A≤80.
Perhaps, described protein is phytoprotein, and phytoprotein accounts for A part of total weight of fiber, 1≤A≤80.
Also can be, described protein be the mixture of phytoprotein and animal protein, and the total amount of phytoprotein and animal protein accounts for A part of total weight of fiber, 1≤A≤80, and wherein phytoprotein accounts for E part of protein gross weight, 1≤E≤99.
Protein fibre of the present invention can be natural protein fibre.
The invention provides a kind of preparation method who prevents and treats the medical protein fiber of the proliferation of mammary gland, comprising: the first step, make spinning solution by protein, high molecular polymer, the medicine of preventing and treating the proliferation of mammary gland and drug transdermal sorbefacient; In second step, make a kind of medical protein fiber of preventing and treating the proliferation of mammary gland by this spinning solution.
In the inventive method, described medicine and the drug transdermal sorbefacient of preventing and treating the proliferation of mammary gland adds proteinaceous spinning solution, and stir, wherein, the solid amount of doing of proliferation of mammary gland medicine of preventing and treating that adds is C part, 0<C≤20, the solid amount of doing of the drug transdermal sorbefacient of adding is D part, 0<D≤10.
On the said method basis, a kind of preparation method who prevents and treats the medical protein fiber of the proliferation of mammary gland is: in second step, the method that adopts when making fiber by spinning solution is wet spinning technology, dry-spinning process or dry-jet wet spinning process.
The medical protein fiber of preventing and treating the proliferation of mammary gland of the present invention can be used for making the cloth of the pharmacologic action with the proliferation of mammary gland of preventing and treating, and this cloth can be attached to the internal layer or the endosexine of brassiere as the internal layer lining of brassiere.
Concrete using method is: according to the requirement of fabric index parameters such as the fabric structure of common brassiere internal layer lining, Density, the medical protein fiber of preventing and treating the proliferation of mammary gland is made into cloth, then, as brassiere internal layer lining, make medicinal bra with this cloth according to the manufacturing process and the method for common brassiere.
The present invention has following advantage: 1, manufacture craft is simple, is easy to realize; 2, raw material sources are abundant, and are with low cost; 3, the brassiere made from the medical protein fiber cloth of preventing and treating the proliferation of mammary gland is prevented and treated the proliferation of mammary gland, and medication is convenient, side effect is little, and does not influence patient's external beauty, meets very much the hommization demand that modern female is cured the disease and pursued beauty.
Specific embodiment
A kind of medical protein fiber of preventing and treating the proliferation of mammary gland, by the percentage composition that accounts for total weight of fiber is the protein of A part, the percentage composition that accounts for total weight of fiber is the high molecular polymer of B part, the percentage composition that accounts for total weight of fiber is the medicine of C part, the percentage composition that accounts for total weight of fiber is that the drug transdermal sorbefacient of D part is formed, then: 1≤A≤80,1≤B≤80,0<C≤20,0<D≤10, wherein, described high molecular polymer is one or more the composition in polyvinyl alcohol, polyacrylonitrile, cellulose, the polyvinyl acetate; Described medicine can be more than one composition of a kind of in tamoxifen, isoflavones, Bromocriptine and the danazol or its; Described drug transdermal sorbefacient can be more than one composition of a kind of in azone, oleic acid, N-N-methyl-2-2-pyrrolidone N-, propylene glycol, the borneol or its.
Medical protein fiber of specifically preventing and treating the proliferation of mammary gland and its production and use is exemplified below:
Embodiment 1:
The first step, the preparation spinning solution.The spinning solution that contains earlier protein and high molecular polymer by existing prepared, wherein, it is 50 weight portions that the doing of protein measured A admittedly, it is 49 weight portions that the doing of high molecular polymer measured B admittedly.To prevent and treat the medicine of the proliferation of mammary gland and drug transdermal sorbefacient then adds in this spinning solution and stirs, admittedly to measure C be 0.5 weight portion to the doing of proliferation of mammary gland medicine of preventing and treating that adds, and it is 0.5 weight portion that the doing of the drug transdermal sorbefacient of adding measured D admittedly;
Second step, to contain the spinning solution of preventing and treating proliferation of mammary gland medicine and drug transdermal sorbefacient and make medical protein fiber, adopt wet spinning technology, dry-spinning process or dry-jet wet spinning process all can, both contain protein in the medical protein fiber of making, contained medicine and the drug transdermal sorbefacient of preventing and treating the proliferation of mammary gland again;
Be made into cloth with the medical protein fiber of making, and make brassiere as the internal layer lining of brassiere, then both contained protein in the internal layer lining of brassiere, contain medicine and the drug transdermal sorbefacient of preventing and treating the proliferation of mammary gland again with this cloth.
In the present embodiment, preventing and treating the protein that contains in the medicinal fibre of the proliferation of mammary gland can be animal protein, also can be phytoprotein.
In the present embodiment, high molecular polymer can be one or more in polyvinyl alcohol, polyacrylonitrile, third rare nitrile, cellulose, the polyvinyl acetate.
In the present embodiment, the medicine of preventing and treating the proliferation of mammary gland can be a kind of in the clinical already used medicine of preventing and treating the proliferation of mammary gland of tamoxifen (TAM), isoflavones (isoflavones), Bromocriptine (bromocriPtine), danazol (danazol) or other.
In the present embodiment, the drug transdermal sorbefacient can be a kind of in azone, oleic acid, N-N-methyl-2-2-pyrrolidone N-, propylene glycol, borneol or the other medicines skin penetration enhancer.
In the present embodiment, the medical protein fiber of preventing and treating the proliferation of mammary gland is made into the operation of cloth, adopts the weaving process of existing brassiere internal layer lining.
In the present embodiment, adopt the production process of common brassiere to make brassiere, its internal layer cloth that the medical protein fiber of preventing and treating the proliferation of mammary gland is made into of serving as reasons.
Embodiment 2:
In the present embodiment, in the spinning solution protein do that to measure A admittedly be 80 weight portions, it is 15 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 4 weight portions, it is 1 weight portion that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 3:
In the present embodiment, in the spinning solution protein do that to measure A admittedly be 30 weight portions, it is 60 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 8 weight portions, it is 2 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 4:
In the present embodiment, in the spinning solution protein do that to measure A admittedly be 20 weight portions, it is 75 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 2.5 weight portions, it is 2.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 5:
In the present embodiment, in the spinning solution protein do that to measure A admittedly be 10 weight portions, it is 80 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 5.5 weight portions, it is 4.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 6:
In the present embodiment, in the spinning solution protein do that to measure A admittedly be 40 weight portions, it is 40 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 16 weight portions, it is 4 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 7:
In the present embodiment, in the spinning solution protein do that to measure A admittedly be 70 weight portions, it is 15 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 9.5 weight portions, it is 5.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 8:
In the present embodiment, protein does that to measure A admittedly be 42.5 weight portions in the spinning solution, it is 37.5 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 18.5 weight portions, it is 1.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 9:
In the present embodiment, protein does that to measure A admittedly be 39.5 weight portions in the spinning solution, it is 47.5 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 3.5 weight portions, it is 9.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 10:
In the present embodiment, in the spinning solution protein do that to measure A admittedly be 25 weight portions, it is 70 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 1.5 weight portions, it is 3.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 11:
In the present embodiment, in the spinning solution protein do that to measure A admittedly be 60 weight portions, it is 20 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 12.5 weight portions, it is 7.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 12:
In the present embodiment, the protein that contains in the spinning solution is the mixture of animal protein and phytoprotein, in the mixture of two kinds of protein, it is 1 weight portion that the doing of phytoprotein measured E admittedly, mixed protein total does and measure A admittedly is 50 weight portions, and it is 49 weight portions that the doing of high molecular polymer measured B admittedly, and preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 0.5 weight portion, it is 0.5 weight portion that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 13:
In the present embodiment, protein does that to measure A admittedly be 80 weight portions in the spinning solution, phytoprotein accounts for doing of protein to measure E admittedly is 99 weight portions in the protein, it is 15 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 4 weight portions, it is 1 weight portion that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 14:
In the present embodiment, protein does that to measure A admittedly be 30 weight portions in the spinning solution, wherein phytoprotein accounts for doing of protein to measure E admittedly is 50 weight portions, it is 60 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 8 weight portions, it is 2 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 15:
In the present embodiment, protein does that to measure A admittedly be 20 weight portions in the spinning solution, wherein phytoprotein accounts for doing of protein to measure E admittedly is 25 weight portions, it is 75 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 2.5 weight portions, it is 2.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 16:
In the present embodiment, protein does that to measure A admittedly be 10 weight portions in the spinning solution, wherein phytoprotein accounts for doing of protein to measure E admittedly is 75 weight portions, it is 80 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 5.5 weight portions, it is 4.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 17:
In the present embodiment, protein does that to measure A admittedly be 40 weight portions in the spinning solution, wherein phytoprotein accounts for doing of protein to measure E admittedly is 15 weight portions, it is 40 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 16 weight portions, it is 4 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 18:
In the present embodiment, protein does that to measure A admittedly be 70 weight portions in the spinning solution, phytoprotein does that to measure E admittedly be 85 weight portions in the protein, it is 15 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 9.5 weight portions, it is 5.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 19:
In the present embodiment, protein does that to measure A admittedly be 42.5 weight portions in the spinning solution, wherein phytoprotein accounts for doing of protein to measure E admittedly is 55 weight portions, it is 37.5 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 18.5 weight portions, it is 1.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 20:
In the present embodiment, protein does that to measure A admittedly be 39.5 weight portions in the spinning solution, wherein phytoprotein accounts for doing of protein to measure E admittedly is 45 weight portions, it is 47.5 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 3.5 weight portions, it is 9.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 21:
In the present embodiment, protein does that to measure A admittedly be 25 weight portions in the spinning solution, phytoprotein does that to measure E admittedly be 80 weight portions in the protein, it is 70 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 1.5 weight portions, it is 3.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.
Embodiment 22:
In the present embodiment, protein does that to measure A admittedly be 60 weight portions in the spinning solution, phytoprotein does that to measure E admittedly be 20 weight portions in the protein, it is 20 weight portions that the doing of high molecular polymer measured B admittedly, preventing and treating doing of proliferation of mammary gland medicine, to measure C admittedly be 12.5 weight portions, it is 7.5 weight portions that the doing of drug transdermal sorbefacient measured D admittedly, and other method is identical with embodiment 1.