CN100438879C - New process for making animal medicine madumycin ammonium, ivermection or dikezhuli premixed agent - Google Patents
New process for making animal medicine madumycin ammonium, ivermection or dikezhuli premixed agent Download PDFInfo
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- CN100438879C CN100438879C CNB031213995A CN03121399A CN100438879C CN 100438879 C CN100438879 C CN 100438879C CN B031213995 A CNB031213995 A CN B031213995A CN 03121399 A CN03121399 A CN 03121399A CN 100438879 C CN100438879 C CN 100438879C
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- ammonium
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- ivermectin
- diclazuril
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Abstract
The present invention provides a technique for preparing maduramicin ammonium as a veterinary medicine, ivermectin or a diclazuril premixing substance. The technique has the advantages that organic solvent is not used, products, production devices and the atmospherical environment are not polluted, the production cost is greatly reduced, raw materials are not decomposed, the production efficiency is high, the uniformity and the flowing property of the premixing substance are high, etc.
Description
Technical field
The present invention relates to a kind of technology of making the veterinary drug pre-mixing agent, more particularly, the present invention relates to the technology of a kind of manufacturing veterinary drug Maduramycin Ammonium (Maduramicin Ammonium), ivermectin (Ivermectin) or diclazuril (Diclazuril) pre-mixing agent
Background technology
As everyone knows, chicken coccidiosis can cause the stagnation of chicken growth promoter, and egg production reduces (thereby the price of deed is reduced), also can make chicken death when serious.When adopting intensive method to raise chickens, the easier generation of coccidiosis, therefore preventing and treating chicken coccidiosis is to need the conscientiously problem of solution now.
Have found that, the antibiotic veterinary drug Maduramycin Ammonium of polyethers is the active drug of prevention and treatment chicken coccidiosis, but chicken eats the quantity of Maduramycin Ammonium by feedstuff should be suitable, during the amount of eating too high (feedstuff that for example the chicken feeding of non-ball worm disease is contained the above Maduramycin Ammonium of 6ppm) chicken poisoned, its growth is subjected to obvious inhibition, weightening finish slows down, and feather reduces, even can appetite descend, legs and feet feel like jelly, and eye discharge increases; Otherwise, low excessively if chicken food is gone into amount, then do not reach preventive effect again.All these requirement is distributed to Maduramicin in the feedstuff equably, makes that the content of Maduramycin Ammonium is about 5ppm in the feedstuff.But Maduramycin Ammonium is the pulverulent solids similar to milk powder, be difficult for to mix, and this makes and more difficult it is distributed in the feedstuff equably.In addition, according to general provision, with Maduramycin Ammonium prevention and treatment chicken coccidiosis the time, its addition is 4.54-5.45 gram, the i.e. concentration of about 5ppm in feedstuff per ton.Want to make Maduramycin Ammonium can reach equably under so low concentration and distribute, difficulty more will become.
In order to solve this difficulty, prior art adopts the way of premix more, for example Chinese invention patent ublic specification of application CN1266684A for example is dissolved in water-fast Maduramycin Ammonium earlier in the organic solvent such as butyl acetate, benzyl alcohol, then gained solution evenly is sprayed onto on bean cake or the corn core carrier, after stirring, mixing, drying, form pre-mixing agent, at last pre-mixing agent is measured on demand with feedstuff and mixed, use for chicken food.But this technology has following shortcoming: 1, organic solvent evaporate in the air and pollutes the environment.In addition, it is not that not volatile organic solvent can stain product that organic solvent is held, and the product after staiing can produce certain harm to animal; Organic solvent also can stain mixing apparatus, the feasible cleaning that is unfavorable for equipment.These all make manufacturer be difficult for pharmaceutical production management regulation (GMP) authentication by formulating for national drug manufacturing enterprise; Also, cost is increased, for example produce 1 ton of product and need cost 1650 yuan with 25 kilograms of solvent benzol methanol because used organic solvent; 2, the bad raw material of heat stability is decomposed; 3, production stage is many, and production efficiency is not high.
The situation and the Maduramycin Ammonium of veterinary drug ivermectin and diclazuril are just the same.
Therefore expect to have a kind of method that can overcome manufacturing Maduramycin Ammonium, ivermectin and the diclazuril pre-mixing agent of above-mentioned shortcoming.
Purpose of the present invention just provide a kind of novelty manufacturing Maduramycin Ammonium, ivermectin and diclazuril pre-mixing agent method it should overcome the shortcoming of prior art, have excellent economic benefit and social benefit.
Summary of the invention
Through deeply, extensive studies, what the inventor had worked out a kind of novelty makes the method for Maduramycin Ammonium, ivermectin and diclazuril pre-mixing agent with dry pelletizing method.
A kind of wet type prilling process is arranged in the prior art, promptly in comminutor, will need the single or multiple powder material of pelletize in ebullated bed, to form fluidization, realize simultaneously mixing; Atomizing is sprayed onto the fluidization interface through spray gun with binding agent; Material cohesion granulating And is dried.Because it has the shortcoming of above-mentioned spraying premix method equally, the inventor does not adopt wet granulation.
Method for making of the present invention is to adopt dry pelletizing method to make the Maduramicin ammonium premix, and it comprises the following steps:
1, the former powder of Maduramycin Ammonium directly is pressed into granule with Drygranulatemachine, particulate granularity is the 30-80 order; Also can in Drygranulatemachine, directly be pressed into granule with the mixture of former powder of Maduramycin Ammonium and starch; the part by weight of former powder of Maduramycin Ammonium and starch is 1: 3 to 3: 1 in the mixture; but this ratio is not strict with, and the particulate granularity that is pressed into also is the 30-80 order.
2, be that 30-80 purpose carrier is put in the blender with prepared Maduramycin Ammonium granule and granularity, it is 0.1-2% weight that the addition of Maduramycin Ammonium should make its content in the Maduramicin ammonium premix, and the Maduramicin ammonium premix gets product after stirring.
Used Drygranulatemachine is general Drygranulatemachine, process such as carry out tabletting, cutting, discharging in comminutor, sieve.
With the former powder pelletize of Maduramycin Ammonium, with mixture pelletize in Drygranulatemachine of former powder of Maduramycin Ammonium and starch, because this equals to carry out premix one time, so the pre-mixing agent that is mixed and made into carrier again with this granule, its uniformity is better compared with single.
Used carrier can be a maize cob meal, can be grain and paddy corium farinosum such as soybean cake powder, bean cake powder, wheat bran, Testa oryzae, wheat-middlings, Semen Maydis powder also, and granularity is the 30-80 order.Because carrier granular is close aspect granularity and unit weight with the Maduramycin Ammonium granule that makes above, so the uniformity of product pre-mixing agent can reach requirement, and is better than prior art.
The Maduramicin ammonium premix that makes with the inventive method meets the regulation of " Chinese veterinary drug allusion quotation " and " veterinary drug quality standard " fully.
Not miscible veterinary drug such as ivermectin and diclazuril are used with quadrat method and are handled, and also can make corresponding pre-mixing agent.
Prepared pre-mixing agent more on demand amount with can be after feedstuff mixes for hello chicken usefulness.Because the made pre-mixing agent of the present invention is a spheroidal particle, its free-running property has improved, so the mixed performance of it and feedstuff improved, and can obtain uniform mixture after the mixing, the coefficient of variation≤5%.
Compared with prior art, the new method of manufacturing veterinary drug Maduramycin Ammonium of the present invention, ivermectin or diclazuril pre-mixing agent has following advantage: 1, not with an organic solvent, therefore not polluted product, production equipment and atmospheric environment also greatly reduce production cost; 2, do not need heat drying, thereby avoided the bad raw material of heat stability to produce the danger of decomposing; 3, the step of Sheng Chaning has reduced, thereby production efficiency has improved; 4, the uniformity of made pre-mixing agent has improved, and Diaspora Performance has also improved.
The following examples are used to explain the present invention, but this never means limitation of the scope of the invention.
Embodiment 1
10 kilograms of former powder of Maduramycin Ammonium directly are pressed into granule with Drygranulatemachine, and particulate granularity is the 30-80 order.
Is prepared Maduramycin Ammonium granule and granularity that 30-80 purpose corn cob granule is put in the blender of 2000 liters, after stirring, promptly obtains finished product Maduramicin ammonium premix.
Claims (6)
1. a method of making veterinary drug Maduramicin ammonium premix is characterized in that it comprises the following steps:
(1) mixture with former powder of Maduramycin Ammonium and starch directly is pressed into granule in Drygranulatemachine, and the part by weight of former powder of Maduramycin Ammonium and starch is 1: 3 to 3: 1 in the mixture, and the particulate granularity that is pressed into is the 30-80 order;
(2) be that 30-80 purpose carrier is put in the blender with prepared Maduramycin Ammonium granule and granularity, it is 0.1-2% weight that the addition of Maduramycin Ammonium should make its content in its pre-mixing agent, and the Maduramicin ammonium premix gets product after stirring.
2. a method of making veterinary drug ivermectin pre-mixing agent is characterized in that it comprises the following steps:
(1) mixture with former powder of ivermectin and starch directly is pressed into granule in Drygranulatemachine, and the part by weight of former powder of ivermectin and starch is 1: 3 to 3: 1 in the mixture, and the particulate granularity that is pressed into is the 30-80 order;
(2) be that 30-80 purpose carrier is put in the blender with prepared ivermectin granule and granularity, it is 0.1-2% weight that the addition of ivermectin should make its content in its pre-mixing agent, and the ivermectin pre-mixing agent gets product after stirring.
3. a method of making veterinary drug diclazuril pre-mixing agent is characterized in that it comprises the following steps:
(1) mixture with former powder of diclazuril and starch directly is pressed into granule in Drygranulatemachine, and the part by weight of former powder of diclazuril and starch is 1: 3 to 3: 1 in the mixture, and the particulate granularity that is pressed into is the 30-80 order;
(2) be that 30-80 purpose carrier is put in the blender with prepared diclazuril granule and granularity, it is 0.1-2% weight that the addition of diclazuril should make its content in its pre-mixing agent, and the diclazuril pre-mixing agent gets product after stirring.
4. the method for manufacturing veterinary drug Maduramicin ammonium premix according to claim 1 is characterized in that described carrier is maize cob meal, soybean cake powder, bean cake powder, wheat bran, Testa oryzae, wheat-middlings or Semen Maydis powder.
5. the method for manufacturing veterinary drug ivermectin pre-mixing agent according to claim 2 is characterized in that described carrier is maize cob meal, soybean cake powder, bean cake powder, wheat bran, Testa oryzae, wheat-middlings or Semen Maydis powder.
6. the method for manufacturing veterinary drug diclazuril pre-mixing agent according to claim 3 is characterized in that described carrier is maize cob meal, soybean cake powder, bean cake powder, wheat bran, Testa oryzae, wheat-middlings or Semen Maydis powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031213995A CN100438879C (en) | 2003-03-27 | 2003-03-27 | New process for making animal medicine madumycin ammonium, ivermection or dikezhuli premixed agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031213995A CN100438879C (en) | 2003-03-27 | 2003-03-27 | New process for making animal medicine madumycin ammonium, ivermection or dikezhuli premixed agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1460485A CN1460485A (en) | 2003-12-10 |
| CN100438879C true CN100438879C (en) | 2008-12-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB031213995A Expired - Fee Related CN100438879C (en) | 2003-03-27 | 2003-03-27 | New process for making animal medicine madumycin ammonium, ivermection or dikezhuli premixed agent |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101273968B (en) * | 2008-05-06 | 2010-06-09 | 浙江汇能动物药品有限公司 | Maduramicin ammonium solid dispersion and method for preparing the same |
| CN101879142B (en) * | 2010-06-11 | 2011-09-07 | 濮阳泓天威药业有限公司 | Preparation method of maduramicin ammonium premix |
| CN102511666A (en) * | 2011-12-29 | 2012-06-27 | 王广玉 | Oregano oil premix for livestock and poultry and preparation method |
| CN107647114A (en) * | 2017-11-06 | 2018-02-02 | 四川恒通动保生物科技有限公司 | A kind of method of pellet addition medicine |
| CN108013239A (en) * | 2018-01-19 | 2018-05-11 | 福建小薇金匙科技孵化有限公司 | A kind of nutrition fermented feed processing method for having sheep endoparasite prophylactic-therapeutic effect concurrently |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1266684A (en) * | 1999-03-16 | 2000-09-20 | 汪明 | Compound preparation for treating coccidiosis |
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2003
- 2003-03-27 CN CNB031213995A patent/CN100438879C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1266684A (en) * | 1999-03-16 | 2000-09-20 | 汪明 | Compound preparation for treating coccidiosis |
Non-Patent Citations (2)
| Title |
|---|
| 头孢氨胶囊剂的工艺改进. 天津药学，第12卷第3期. 2000 |
| 头孢氨胶囊剂的工艺改进. 天津药学，第12卷第3期. 2000 * |
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| CN1460485A (en) | 2003-12-10 |
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Granted publication date: 20081203 Termination date: 20140327 |