CN100424089C - Method for preparing macrolides half-synthesized antibiotics telithromycin - Google Patents
Method for preparing macrolides half-synthesized antibiotics telithromycin Download PDFInfo
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- CN100424089C CN100424089C CNB2006100378504A CN200610037850A CN100424089C CN 100424089 C CN100424089 C CN 100424089C CN B2006100378504 A CNB2006100378504 A CN B2006100378504A CN 200610037850 A CN200610037850 A CN 200610037850A CN 100424089 C CN100424089 C CN 100424089C
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Abstract
The present invention discloses a novel method for preparing macrolides semisynthesized antibiotics telithromycin, which comprises the following steps: a. mother nucleus preparation: methoxy-erythromycin as raw material reacts with carbonyldiimidazole to prepare an intermediatebody (VI) after dehydration, acylation, esterification, oxidization, and dehydration under the action of organic strong bases; b. branched chain preparation: 3-acetylpyridine as raw material reacts with N-(4-bromobutyl)-phthalimide under the condition of inorganic strong bases to prepare a branched chain (XIII) after bromination, reaction with urotropine, hydrolysis, cyclization with potassium thiocyanate, and reaction with dilute nitric acid; c. telithromycin synthesis: the intermediate body (VI) reacts with the branched chain (XIII) to synthesize the telithromycin. The method has the advantages of low cost and safe reaction, and is suitable for industrialized preparation.
Description
Technical field
The invention belongs to pharmacy field, relate to a kind of method for preparing macrolides half-synthesized antibiotics telithromycin.
Background technology
People such as Agouridas are at J.Med.Chem.1998, and 41:4080-4100 reports the following route of synthetic employing of Ketek:
Wherein side chain is synthetic as follows:
In this route, exist oxidizing reaction agents useful for same EDC-HCl (1-[3-(dimethylamino) propyl group]-3-ethyl-carbodiimide hydrochloride) to cost an arm and a leg, consumption is big, reaction yield is low, and the problem of purification difficult is in the building-up process of side chain, used potassium metal, dangerous big, not easy to operate, suitability for industrialized production has certain difficulty.
Summary of the invention
The objective of the invention is to prepare the problem that exists in compound (I) method, a kind of novel method for preparing macrolides half-synthesized antibiotics telithromycin is provided, satisfy industrial production requirement at bibliographical information.
The objective of the invention is to realize by following technical measures:
Preparation process to compound (I) of the present invention is as follows:
Side chain synthetic as follows:
Among the present invention, compound (II) can be carried out acetylize with aceticanhydride and be obtained by 6-methoxyl group erythromycin (clarithromycin) desugar in 5~15% hydrochloric acid again.
Among the present invention, [esterifying reagent is diethyl carbonate, phosgene (phosgene), trichloromethylchloroformate (superpalite) or triphosgene (two trichloromethyl carbonate) to compound (II) under a condition, preferred diethyl carbonate] reaction, preparation compound (III).The consumption of esterifying reagent is 10~25 times of equivalents of compound (II).During by compound (II) preparation compound (III), solvent for use is chloroform, methylene dichloride, benzene or toluene, preferred toluene.
Among the present invention, [chemical oxidization method adopts the oxygenant contain chromium to compound (III), as potassium bichromate (sodium), chromic acid, chromium trioxide, chromium trioxide+pyridine, chromium trioxide+trimethyl carbinol, Jones reagent (chromium trioxide+sulfuric acid) etc. under the b condition; Manganiferous oxygenant, as: potassium permanganate etc.; The oxygenant that contains methyl-sulphoxide, as, methyl-sulphoxide+oxalyl chloride, methyl-sulphoxide+DCC (dicyclohexylcarbodiimide) or EDC (1-[3-(dimethylamino) propyl group]-3-ethyl-carbodiimide hydrochloride), methyl-sulphoxide+aceticanhydride, methyl-sulphoxide+phosgene (or trichloromethylchloroformate, triphosgene) etc.; Perhaps adopt the method for catalyzed oxidation, the oxidation that the method for catalyzed oxidation adopts the catalyzer that contains precious metal (as: platinum, palladium etc.) and oxygen or air to carry out] carry out oxidizing reaction, make compound (IV).The consumption of chemical oxidation reagent is a 4-20 times of equivalent of compound (III);
Among the present invention, [organic alkali is as DBU (1,5-diazabicylo [5,4,0] hendecene-5) under the c condition for compound (IV); DBN (1,5-diazabicyclo [4,3,0] nonene-5) etc.] through dehydration preparation (V).The consumption of organic alkali is 2~10 times of equivalents of compound (IV).
Among the present invention, compound (V) under the d condition [inorganic strong alkali (and as NaH, KH, NaNH
2Deng) the following and CDI (carbonyl dimidazoles) of catalysis] prepared in reaction (VI).The consumption of inorganic strong alkali is 2~10 times of equivalents of compound (V).
Among the present invention, the 3-acetylpyridine is [liquid bromine, N-bromo-succinimide (NBS) etc.] bromo preparation (VII) under the e condition.
Among the present invention, compound (VII) is in [urotropine] reaction under the f condition and hydrolysis preparation (VIII) under acidic conditions.
Among the present invention, compound (VIII) is [KSCN] cyclization preparation (IX) under the g condition.
Among the present invention, compound (IX) is [method for hydrogenation (hydrogenation of employing raney ni catalysis is taken off sulfydryl or adopted palladium carbon catalytic hydrogenation to take off sulfydryl, preferred raney ni catalysis hydro-desulfurization) under the h condition; Perhaps adopt non-method for hydrogenation (is that 5~15% dilute nitric acid reaction takes off sulfydryl with concentration)] prepared in reaction (X).
Among the present invention, compound (X) is [inorganic strong alkali (NaH, KH or NaNH under the i condition
2)] and N-(4-brombutyl)-phthalic imidine prepared in reaction (XII).The consumption of inorganic strong alkali is 2~10 times of equivalents of compound (X).
Among the present invention, [acidic conditions (concentration is 5~15% dilute hydrochloric acid, dilute sulphuric acid or rare nitric acid, preferred dilute hydrochloric acid) hydrolysis down makes compound (XII) under the j condition; Perhaps hydrazinolysis makes under alkaline condition (hydrazine hydrate)] prepared in reaction (XIII).
Beneficial effect of the present invention:
1, the present invention expensive reagent EDC.HCl of need not to use, production cost is low;
2, the present invention has adopted Delepine method (bromide reacts then hydrolysis under the acidic conditions with urotropine earlier) to side chain synthetic, has replaced very dangerous potassium metal, and security is good;
3, the present invention is fit to suitability for industrialized production.
Embodiment
The following examples can make those skilled in the art more fully understand the present invention, but do not limit the present invention in any way.
The strong aqua that uses in the embodiment of the invention, concentrated hydrochloric acid, concentrated nitric acid are the commercially available prod.
Embodiment 1:
3-takes off [(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-pyrans nuclear hexose-based) oxygen]-6-O-erythromycin
6-O-erythromycin (clarithromycin) 60.0g (80.4mmol) is scattered in the hydrochloric acid of 1000ml 1M, stir about 5h under the room temperature, transfer pH to 8~9 with strong aqua, adding solid sodium chloride reaches capacity solution, filter, wash white solid, get 40.2g with acetone and sherwood oil (60-90 ℃) recrystallization, yield 84.9%, mp 236-240 ℃.
IR(KBr)1690,1734cm
-1
1HNMR(CDCl
3)δ5.18(dd,1H,C-13H,J=13.5Hz),2.97(s,3H,C-6OCH
3),2.25(s,6H,N(CH
3)
2)ppm
MS(ESI)m/e:590(M+H)
+
Embodiment 2:
2 '-O-ethanoyl-3-takes off [(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-pyrans nuclear hexose-based) oxygen]-6-O-erythromycin (II):
3-takes off [(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-pyrans nuclear hexose-based) oxygen]-6-O-erythromycin (being obtained by embodiment 1) 40.0g (68mmol) is dissolved among methylene dichloride 400ml and the triethylamine 11.6ml (80.4mmol), ice bath drips acetic anhydride 13.44ml (141.12mmol) down, remove ice bath after finishing, react 3.5h under the room temperature.Add saturated NaHCO
3Aqueous solution 150ml uses chloroform extraction, and anhydrous sodium sulfate drying filters, removal of solvent under reduced pressure, and crude product obtains white soft solid 39g, yield 90.9%, mp 156-160 ℃ with ethyl acetate and sherwood oil (15: 1) recrystallization.
IR(KBr)1690,1734,1741cm
-1
1HNMR(CDCl
3)δ4.85(dd,1H,C-2’CHOAC,J=18Hz),3.04(s,3H,C-6OCH
3),2.36(s,6H,N(CH
3)
2),2.16(s,3H,OCOCH
3)ppm
MS(ESI)m/e:632(M+H)
+
Embodiment 3:
2 '-O-ethanoyl-3-takes off [(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-pyrans nuclear hexose-based) oxygen]-6-O-methyl isophthalic acid 1,12-carbonic ether erythromycin (III)
Compound (II) (being obtained by embodiment 2) 20 grams (31.7mmol) are dissolved in the 200ml toluene, add diethyl carbonate 40g (450.5mmol), Anhydrous potassium carbonate 40g (290mmol), and room temperature reaction 9 hours is washed anhydrous MgSO three times
4Drying, removal of solvent under reduced pressure get the off-white color solid, get pure product 15.6g with the acetone soln recrystallization, yield 75%, m.p.92~93 ℃.
IR(KBr)3540,1814,1741,1715cm
-1
1HNMR(CDCl
3)δ5.0(dd,1H,H
13,J=2.4,10.2Hz),2.64(s,3H,6-O-CH
3),2.24(s,6H,N(CH
3)
2),2.04(s,3H,2’OCOCH
3)ppm
MS(ESI)m/e:658(M+H)
+
Embodiment 4:
2 '-O-ethanoyl-3-takes off [(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-pyrans nuclear hexose-based) oxygen]-6-O-methyl-3-oxo-11,12-carbonic ether erythromycin (IV)
Method one:
Compound (III) 14.2g (21.6mmol) stirring and dissolving is in anhydrous methylene chloride 200ml, add 30 ℃ of reacting by heating 16h of P.C.C (pyridinium chloro-chromate) 28.7g. oil bath, filter, reaction flask swings with methylene dichloride 2 * 25ml to be washed, the combined dichloromethane layer, use the saturated sodium bicarbonate aqueous solution washed twice, wash once anhydrous MgSO
4Drying, removal of solvent under reduced pressure obtain brown solid 5 (13.3g, yield 94%), can be directly used in the next step without separation.Analytic sample 13.3g is with sherwood oil: acetone: triethylamine (10: 4: 1) is an eluent, and column chromatography gets rice white solid (IV) 11.7 grams, pure product yield 82.7%, m.p.105~106 ℃.
Method two:
In the 250ml two neck bottles that thermometer and drying tube are housed, add 9.49g (0.12mols) anhydrous pyridine and the anhydrous CH of 150ml
2Cl
2, after temperature was 5 ℃ in ice bath was chilled to, disposable adding 6.0g (0.06mol) CrO
3, solution becomes dark grape wine redness.After this temperature continues stirring reaction 5min, approximately slowly be warming up to 20 ℃ through the 60min time.Add 10ml fast and be dissolved with compound (III) (3.28g, anhydrous CHCl 0.005mol)
2Solution, reaction system have the black insolubles to produce at once.Continue stirring reaction 20min, filter, reaction flask is with the anhydrous CH of 3 * 30ml
2Cl
2Swing and wash, organic layer is with the saturated NaHCO of 3 * 50ml
3Solution washing, anhydrous Na
2SO
4Dry 5 hours, filter, precipitation gets the brown crude product.With sherwood oil: acetone: triethylamine=10: 4: 1 is the eluent column chromatography, white products 1.31g, yield is 40%.
Method three:
Guard against in the 150ml three-necked bottle that stirs in the machine that is equipped with, add the anhydrous CH of 100ml
2Cl
2, 3.3g PDC opens and stirs, makes it to suspend, adding compound (III) (3.0g, 4.57mmol).Room temperature reaction 24h, TLC show that raw material reacts completely.Filter, with the CH of 15ml * 3
2Cl
2Swing and wash reaction flask three times.Merge organic layer, anhydrous magnesium sulfate drying, precipitation, resistates are with sherwood oil: acetone: triethylamine=10: 4: 1 be the eluent column chromatography, must white products 2.1g, yield 70.1%.
IR(KBr)1812,1748,1713cm
-1
1HNMR(CDCl
3)δ5.01(dd,1H,H
13,J=1.6,6Hz),4.73(dd,1H,H
2’,J=4.6,6.3Hz),4.37(d,1H,H
1’,J=4.6Hz),4.16(s,1H,H
5),2.67(s,3H,6-OCH
3),2.23(s,6H,N(CH
3)
2)ppm
MS(ESI)m/e:656(M+H)
+
Embodiment 5:
2 '-O-ethanoyl-3-takes off [(2,6-dideoxy-3-methyl-3-O-methyl-a-L pyrans nuclear hexose-based) oxygen]-6-O-methyl-3-oxo-10,11 dehydration erythromycin (V)
Compound (IV) 11.4g (17.4mmol) stirring and dissolving drips DBU 6.6ml (43.5mmol) and is heated to little reaction 6 hours of boiling in acetone 300ml, filters removal of solvent under reduced pressure, the 200ml that adds methylene chloride dissolving, saturated NaH
2PO
4The aqueous solution 2 * 150ml washing, the saturated NaCl aqueous solution is washed once, anhydrous MgSO
4Drying, removal of solvent under reduced pressure get light yellow solid 9.7g, and with sherwood oil, re-crystallizing in ethyl acetate gets off-white color solid (V) 8g, and yield is 75.2%, m.p.218~219 ℃.
IR(KBr)1747,1713,1670cm
-1
1HNMR(CDCl
3)δ5.02(s,1H,12-OH),6.6(s,1H,H
11),5.01(dd,1H,H
5’,),4.75(dd,1H,H
2’,),2.86(s,3H,6-O-CH
3),2.27(s,6H,N(CH
3)
2),2.06(s,3H,2’-OCOCH
3)ppm
MS(ESI)m/e:612(M+H)
+
Embodiment 6:
2 '-O-ethanoyl-3-takes off [(2,6-dideoxy-3-methyl-3-O-methyl-a-L pyrans nuclear hexose-based) oxygen]-6-O-methyl-3-oxo-10,11 dehydration-12-imidazoles carbonyl acyl group erythromycin (VI)
Compound (V) 8g (13.1mmol) stirring and dissolving is in fresh distillatory anhydrous tetrahydro furan (THF) 200ml, cryosel is bathed and is cooled to-10 ℃, adds NaH 1.05g (43.8mmol), slowly drips the anhydrous THF 60ml solution that is dissolved with CDI 6.34g (39.3mmol), room temperature reaction 6-8 hour, the ice bath cooling drips water 125ml, ethyl acetate extraction, anhydrous magnesium sulfate drying, concentrating under reduced pressure gets off-white color solid (VI) (6.5g, yield 70.4%), m.p.165~167 ℃.
IR(KBr)3129,1749,1714,1673cm
-1
1HNMR (CDCl
3) δ 8.07-7.35-7.05 (dd, 3H, imidazoles hydrogen), 6.77 (s, 1H, H
11), 5.67 (dd, 1H, H
13, J=3.3,9.6Hz), 4.72 (dd, 1H, H
2 ', J=7.5,10.2Hz), 4.35 (d, 1H H
1 ', J=7.5Hz), 4.12 (d, 1H, H
5, J=8.4Hz), 2.76 (s, 3H, 6-OCH
3), 2.24 (s, 6H, N (CH
3)
2) ppm
MS(ESI)m/e:706(M+H)
+
Embodiment 7:
3-acetyl bromide-pyridine hydrobromide salt (VII)
3-acetylpyridine 50g (413mmol) stirs to be dissolved in down and contains among the 10% hydrobromic acetum 335ml, stirring reaction half an hour drips the liquid bromine 66.08g (413mmol) that is dissolved in the 200ml Glacial acetic acid, and temperature control 35-40 ℃ was reacted three hours.Add anhydrous diethyl ether 600ml, freezing crystallization filters, anhydrous diethyl ether washing, dry white solid (VII) (110g, yield 94.7%), m.p.197~199 ℃.
MS(ESI)m/e:201(M+H)
+
Embodiment 8:
3-(alpha-amino group-ethanoyl)-pyridine hydrochloride (VIII)
Compound (VII) 60g (213.5mmol) is added among the anhydrous chloroform 1000ml, ice-water bath is chilled to 15 ℃, add urotropine 48g (342.9mmol), stirred 20 minutes, add NaI 48g (320mmol), stirring at room reaction 8 hours, filter, the chloroform washing is added to filter cake among the concentrated hydrochloric acid 200ml that is chilled to 0 ℃ in batches, adding is chilled to 6 ℃ ethanol 200ml, and temperature control 35-40 ℃ was reacted 5 hours.Freezing, filter filter cake washing with acetone three times.Dry white solid (VIII) (33.45g, yield 75%), m.p.171~172 ℃.
MS(ESI)m/e:137(M+H)
+
Embodiment 9:
5 (4)-3 '-pyridyl-4,5-glyoxalidine-2-sulfydryl (IX)
Compound (VIII) 22g (0.106mol) stirs and is dissolved in the 200ml water, adds potassium sulfocyanate 14g (0.144mol), is heated to 80-90 ℃ of reaction 1.5 hours.Cool off, separate out the hydrochloride 16g of compound, m.p.241-242 ℃.Use Na
2CO
3Solution neutralize compound (IX) (12.2g, yield 65%), m.p.291-292 ℃.
MS(ESI)m/e:178(M+H)
+
Embodiment 10:
5 (4)-3 '-pyridyl-imidazoles (X)
Method one:
The 90ml concentrated nitric acid is dissolved in the 600ml water, is heated to 90 ℃, add compound (IX) 6g (0.034mol) in batches, this thermotonus 1.5 hours.Light yellow solid is separated out in cooling, filters, and uses Na
2CO
3Solution neutralization, be evaporated to dried, ether extraction, concentrate compound (X) (4g, yield 81.1%), m.p.117-118 ℃.
MS(ESI)m/e:146(M+H)
+
Method two:
(5g 20mmol) is dissolved in the 250ml ethanol compound (IX) hydrochloride, adds ZYR-C type Raney's nickel (25g), and reflux 6 hours is filtered, and concentrates the crude product compound (X) (1.5g, yield 51.7%) of recrystallizing methanol, m.p.117-118 ℃.
MS(ESI)m/e:146(M+H)
+
Embodiment 11:
Potassium phthalimide
Phthalic imidine 20g (0.136mol) stirs and is dissolved in the 160ml ethanol, drips 8% KOH methanol solution (being dissolved in the 160ml methyl alcohol 8gKOH formulated), adds the back room temperature reaction 5 hours.Filter absolute ethanol washing, dry white solid 24g, yield 95%, m.p.>300 ℃.
Embodiment 12:
N-(4-brombutyl)-phthalic imidine (XI)
Potassium phthalimide 20g (0.108mol) stirring suspension adds 1 in the 300ml anhydrous propanone, 4-dibromobutane 14ml (0.108mol), and reflux was reacted 24 hours.Filter,, collect filtrate, to going in the 800ml mixture of ice and water, separate out a large amount of white solid (XI) 23g, yield 75.8% under stirring with the small amount of acetone washing leaching cake.
MS(ESI)m/e:282(M+H)
+
Embodiment 13:
2-(4-(3-pyridyl)-1H-imidazoles-1-yl)-butyl-1H-isoindole-1,3-(2H)-ketone (XII)
Sodium hydride 3.5g (0.145mol) stirring suspension is in the anhydrous N of 15ml, in the dinethylformamide (DMF), dropping is dissolved in compound (X) 8g (0.055mol) in the 45ml dry DMF, after dropwising, disposable adding is dissolved in compound (XI) 15.1g (0.054mol) in the 45ml dry DMF.Be heated to 70-75 ℃, reacted 2 hours.Stopped reaction, add water after, with ethyl acetate extraction three times, washing, anhydrous MgSO
4Drying, concentrate crude product, with the compound (XII) (9.5g, yield 50.8%) of re-crystallizing in ethyl acetate, m.p.150-152 ℃.
MS(ESI)m/e:347(M+H)
+
Embodiment 14:
4-(3-pyridyl)-1H-imidazoles-1-butylamine (XIII)
Compound (XII) 8.8g (0.0254mol) stirs and is dissolved in the 240ml ethanol, adds hydrazine hydrate 2.6ml, reflux 8 hours.Concentrate, add the NaOH solution 400ml of 2mol/L, divide three extractions with the 600ml ethyl acetate, after ethyl acetate layer merged, with the NaOH solution 200ml washed twice of 2mol/L, the saturated common salt water washing was extremely neutral, anhydrous MgSO
4Drying, concentrate compound (XIII) (5g, yield 91%).
MS(ESI)m/e:217(M+H)
+
Embodiment 15:
11; 12-dideoxy-3-takes off [(2; 6-dideoxy-3-methyl-3-O-methyl-a-L-pyrans nuclear hexose-based) oxygen]-6-O-methyl-3-oxo-12,11-(oxygen carbonic acyl radical-((4-(4-(3-pyridyl)-1H-imidazoles-1-yl)-butyl)-imido))-erythromycin (I)
Compound (VI) 5.35g (7.6mmol) stirs and is dissolved in the 25ml acetonitrile, adds compound (XIII) 5g (23.1mmol), heating, 70 ℃ of reactions of temperature control 20 hours.Be cooled to room temperature, reaction solution is poured in the 100ml water, used ethyl acetate extraction, washing, anhydrous MgSO4 drying, be concentrated into driedly, add 200ml methyl alcohol, room temperature reaction 3 hours, concentrate crude product, with sherwood oil: acetone: triethylamine (10: 4: 1) is an eluent, and column chromatography gets m.p.186-187 ℃ of white solid (I) (1.5g, yield are 24.3%).
MS(ESI)m/e:812(M+H)
+
1HNMR(CDCl
3)ppm
0.83 (t): CH
3-CH
21.01 (d)-1.07 (d)-1.25 (d)-1.31 (d)-1.38 (d): 2,4,8 and 10 CH
3(s)-1.47 1.34 (s): 6 and 12 CH
32.27 (s): N (CH
3)
22.45 (m): H '
32.62 (s): 6--OCH
32.60 (m): H
82.85-3.25:H
4, H
10And H '
23.52 (m): H
53.56 (s): H
113.60-3.85 (m):
4.23 (d): H
54.27 (d): H '
14.93 (dd): H
137.29 (ddd): pyridine H
58.08 (dt): pyridine H
48.45 (dd): pyridine H
68.97 (dd): pyridine H
27.35 (d) with 7.53 (d): imidazoles H
2And H
5
Claims (16)
1. a method for preparing macrolides half-synthesized antibiotics telithromycin is characterized in that comprising the following steps:
A. parent nucleus preparation: nucleus part is a raw material with 6-methoxyl group erythromycin, make (II) through desugar, 2 ' acetylize, be reacted into (III) with esterifying reagent, oxidation gets (IV), dehydration obtains (V) under the organic alkali effect, makes intermediate (VI) with the carbonyl dimidazoles reaction;
B. side chain preparation: a chain portion is a raw material with the 3-acetylpyridine, elder generation's bromination becomes (VII), get (VIII) with urotropine reaction posthydrolysis, with the thiocyanate-cyclization be (IX), through concentration is that rare nitric acid effect of 5~15% gets (X), (X) react under organic or inorganic highly basic condition and make (XII) with N-(4-brombutyl)-phthalic imidine, hydrazinolysis gets side chain (XIII);
C. synthesizing telithromycin: parent nucleus (VI) and side chain (XIII) react Ketek (I).
2. method according to claim 1, when it is characterized in that by compound (II) preparation compound (III), used esterifying reagent is diethyl carbonate, phosgene, superpalite or two trichloromethyl carbonate; The consumption of esterifying reagent is 10~25 times of equivalents of compound (II).
3. method according to claim 1, when it is characterized in that by compound (II) preparation compound (III), solvent for use is chloroform, methylene dichloride, benzene or toluene.
4. method according to claim 1 is characterized in that by compound (III) used method for oxidation is chemical oxidation method or catalysed oxidation processes when oxidizing reaction prepares compound (IV).
5. method according to claim 4 is characterized in that oxygenant used in the chemical oxidation method is oxygenant, manganiferous oxygenant that contains chromium or the oxygenant that contains methyl-sulphoxide; The consumption of oxidising agent is 4~20 times of equivalents of compound (III).
6. method according to claim 5, the oxygenant that it is characterized in that containing chromium is potassium bichromate, sodium dichromate 99, chromic acid, chromium trioxide, chromium trioxide+pyridine, chromium trioxide+trimethyl carbinol, chromium trioxide+sulfuric acid; Manganiferous oxygenant is a potassium permanganate; The oxygenant that contains methyl-sulphoxide is methyl-sulphoxide+oxalyl chloride, methyl-sulphoxide ten dicyclohexylcarbodiimide, methyl-sulphoxide+1-[3-(dimethylamino) propyl group]-3-ethyl-carbodiimide hydrochloride, methyl-sulphoxide+aceticanhydride, methyl-sulphoxide+phosgene, methyl-sulphoxide+trichloromethylchloroformate or methyl-sulphoxide+triphosgene.
7. method according to claim 4 is characterized in that the oxidation that catalysed oxidation processes adopts the catalyzer contain precious metal and oxygen or air to carry out.
8. method according to claim 1 is characterized in that the organic alkali that (IV) dehydration is adopted when being prepared as (V) is 1,5-diazabicylo [5,4,0] hendecene-5 or 1,5-diazabicyclo [4,3,0] nonene-5; The consumption of organic alkali is 2~10 times of equivalents of compound (IV).
9. method according to claim 1, the inorganic strong alkali that adopts when it is characterized in that compound (V) with carbonyl dimidazoles prepared in reaction (VI) is NaH, KH or NaNH
2The consumption of inorganic strong alkali is 2~10 times of equivalents of compound (V).
10. method according to claim 1, when it is characterized in that preparing compound (VII) by 3-acetylpyridine bromination, used bromizating agent is liquid bromine or N-bromo-succinimide.
11. method according to claim 1, when it is characterized in that preparing compound (VII) by 3-acetylpyridine bromination, used solvent is methyl alcohol, ethanol, chloroform or acetic acid.
12. method according to claim 1 when it is characterized in that by compound (IX) preparation compound (X), has been adopted hydrogenation or non-method for hydrogenation.
13. method according to claim 12 is characterized in that adopting raney ni catalysis to take off sulfydryl or employing palladium carbon catalytic hydrogenation is taken off thin base; It is that 5~15% dilute nitric acid reaction takes off sulfydryl that non-method for hydrogenation adopts concentration.
14. method according to claim 1, the inorganic strong alkali that adopts when it is characterized in that compound (X) and N-(4-brombutyl)-phthalic imidine prepared in reaction (XII) is NaH, KH or NaNH
2The consumption of inorganic strong alkali is 2~10 times of equivalents of compound (X).
15. method according to claim 1 adopts when it is characterized in that by compound (XII) preparation compound (XIII) that hydrazinolysis makes under the alkaline condition.
16. method according to claim 15 is characterized in that alkaline condition adopts hydrazine hydrate.
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CN1090581A (en) * | 1992-11-05 | 1994-08-10 | 鲁索-艾克勒夫公司 | The preparation method of the novel derivative of erythromycin and they and as the application of medicine |
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CN1090581A (en) * | 1992-11-05 | 1994-08-10 | 鲁索-艾克勒夫公司 | The preparation method of the novel derivative of erythromycin and they and as the application of medicine |
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medicinal chemistry letters,Vol.9 . 1999 * |
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novel ketolide antibiotics with a fused five-membered lactonering-synthesis, physicochemical and antimicrobial properties. Daniel hunziker et al.bioorganic &medicinal chemistry,Vol.12 . 2004 |
novel ketolide antibiotics with a fused five-membered lactonering-synthesis, physicochemical and antimicrobial properties. Daniel hunziker et al.bioorganic & * |
novel ketolide antibiotics with a fused five-membered lactonering-synthesis, physicochemical and antimicrobial properties. Daniel hunziker et al.bioorganic &medicinal chemistry,Vol.12 . 2004 * |
synthesis and antibacterial activity of HMR 3647 anewketolide highyly potent against erythromycin-resistantandsusceptible pathogens. alexis denis et al.bioorganic &medicinal chemistry letters,Vol.9 . 1999 |
synthesis and antibacterial activity of HMR 3647 anewketolide highyly potent against erythromycin-resistantandsusceptible pathogens. alexis denis et al.bioorganic & * |
synthesis and antibacterial activity of HMR 3647 anewketolide highyly potent against erythromycin-resistantandsusceptible pathogens. alexis denis et al.bioorganic &medicinal chemistry letters,Vol.9 . 1999 * |
synthesis and antibacterial activity of ketolides(6-O-methyl-3-oxoerythromycin derivatives): a new class ofantibacterials highly potent against macrolide-resistant andsusceptible respiratory. constantin agouridas et al.J.Med.Chem.,Vol.41 . 1998 |
synthesis and antibacterial activity of ketolides(6-O-methyl-3-oxoerythromycin derivatives): a new class ofantibacterials highly potent against macrolide-resistant andsusceptible respiratory. constantin agouridas et al.J.Med.Chem.,Vol.41 . 1998 * |
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