CN100423731C - Eye brightening eye washing liquid and its preparation method - Google Patents
Eye brightening eye washing liquid and its preparation method Download PDFInfo
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- CN100423731C CN100423731C CNB2004100126129A CN200410012612A CN100423731C CN 100423731 C CN100423731 C CN 100423731C CN B2004100126129 A CNB2004100126129 A CN B2004100126129A CN 200410012612 A CN200410012612 A CN 200410012612A CN 100423731 C CN100423731 C CN 100423731C
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Abstract
The present invention relates to an eye-brightening eye-washing solution for the daily health care of eyes and the treatment of eye diseases and a preparation method thereof. The eye-brightening eye-washing solution is prepared from physiological saline, pearl hydrolysis solution, taurine, bacteriostasis preservative and other nutritive substances having the health care action on superficial tissue cells of eyes, which can be used for daily eye washing and immersion for patients with chronic superficial eye diseases, people with corneal contact lenses and other subhealth crowds whose eyes are uncomfortable.
Description
Technical field
The present invention relates to a kind of eye washing eye liquid and preparation method thereof that makes eye bright that is used for eyes daily health caring and curing eye diseases.
Background technology
Eyes are the important window that obtain appearance information, and the information that people recognized has 95% from eyes, so strengthen the great attention that the self-protection of eyes has caused medical science.But in current society, the sickness rate of oculopathy rises day by day, main cause is that following several aspects that have are arranged: 1, the pollution of urban environment air, because the particulate floating eye damage when being easy to make people to go out of the increasing of float, particularly sulfur-bearing in the air; 2, the irradiation of irregular light, as the glass wall in the city, desert, glacier, snowfield, sea etc. dazzle the eyes the influence of dazzling environment also can cause the infringement of eyes; 3, the screen radiation comprises that display device, television set, game machine on the computer also are crucial factors to the injury of eyes, the adolescent myopia rate is increasing year by year through investigation China, it is exactly that the preceding misoperation of screen causes that one major incentive is wherein arranged, secular screen radiation makes the normal function of operator's eyes obstacle occur, cause that asthenopia, visual deterioration, regulatory function obstacle and corneal injury are the most common, severe patient can stimulate injury retina and optic nerve.In addition, eye symptom such as ophthalmalgia, eye acid, eye are done, blurred vision, shed tears etc., in addition because the change of living habit and working method causes the sub-health population of eyes discomfort and also increases gradually, easily cause inflammatory eye as Long term wearing of contact lens; See computer for a long time, see that the people Yi Fasheng eyes of TV are dry and astringent etc.Many for above-mentioned reasons oculopathy such as trachoma, acute and chronic keratitis, conjunctivitis patient increase in a large number, and the symptom that got oculopathy is that eye discharge increases, and growing of pathogenic microorganism causes inflammatory eye, pain.
Be to adopt eye to clean and take orally the method for administration or drug administration by injection medically at present to the treatment of oculopathy, the composition of collyrium is based on normal saline, and add some antibiotic or antiseptic, major function is the eyes that flushing is polluted, and the hospital that has adopts chlorhexidine acetate, mercuric chloride normal saline, Borax collyrium, potassium permanganate liquid collyrium.Open source literature has also been reported the example of many Chinese medicine collyriums, as " preparation of Folium Salicis Babylonicae collyrium and clinical observation on the therapeutic effect ", and Liu Wei Liu Jing east etc., Bethune medical academy, [periodical name] Chinese Hospitals pharmaceutical journal .2003,23 (1) .[digests] purpose; Development Folium Salicis Babylonicae collyrium and observe the curative effect.Method; Get fresh Folium Salicis Babylonicae, adopt prepared such as water is put forward, precipitate with ethanol, ultrafiltration, sterilization, with acycloguanosine eye drip controlled observation.The result: Folium Salicis Babylonicae collyrium popularity hemorrhagic conjunctivitis has curative effect preferably, and effect is better than acycloguanosine.Conclusion: with Folium Salicis Babylonicae collyrium treatment epidemic hemorrhagic conjunctivitis good effect." lining light collyrium treatment acute catarrh conjunctivitis observation of curative effect ", Zhao builds light and thanks to Yun Ping etc., Yunnan Province institute of traditional Chinese medicine of Wenshan Prefecture ophthalmology, [periodical name] Chinese TCM Ophthalmology magazine .2001,11 (4) [digests] from January, 1998 to 2000 year December end, the own Drug Manufacturing Room of Yunnan Province institute of traditional Chinese medicine of Wenshan Prefecture ophthalmic produce, with Chinese herbal medicine Herba Senecionis Scandentis, Herba leucadis ciliatae, Flos Chrysanthemi Indici serve as main preparation in light wash limit liquid treatment acute catarrhal conjunctivitis, obtain significant curative effect." light is washed eye side's treatment acute catarrhal conjunctivitis 47 examples ", Yan Qin Xu Gui Hunan [periodical name] external treatment with Chinese medicine magazine .1996,5 (3) .[digests] acute catarrhal conjunctivitis, show as conjunctiva vasodilation, hyperemia, outward appearance are the red as fire color of a slice, belong to the traditional Chinese medical science " acute and chronic conjunctivitis " category.This paper has discussed with Rhizoma Coptidis, Folium Artemisiae Argyi, Semen Armeniacae Amarum, damp skin treatment acute catarrhal conjunctivitis, and is evident in efficacy, simple and easy to do.This side comes from " hospital examines ", for bright.Wu Kun creates.Fang Zhongtong is respectful clearly, can win heat and make eye bright; The Rhizoma Coptidis hardship is dry, the dampness of can purging heat, and the hot temperature of Folium Artemisiae Argyi can make and drive wind prevailing over dampness, and Semen Armeniacae Amarum Xin Run can promoting the circulation of QI pool skin.Four medicines are harmonious, and play the merit of expelling wind and clearing away heat, eliminating fire and detoxication altogether." therapy of combining Chinese and Western medicine acute hemorrhagic conjunctivitis 120 routine observation of curative effect ", Zhang Guiping history swallow swallow, the practical combination of Chinese and Western medicine magazine .1998 in Sanmenxia City the People's Hospital, Henan Province [periodical name], 11 (3) .[digests] 1996 years carried out the random packet observation to being diagnosed as acute hemorrhagic conjunctivitis 400 examples.The result shows: integrative therapy group curative effect obviously is better than normal saline dotting punch group and SHUANGHUANLIAN saline dotting punch group, and healing time also is significantly shorter than two matched groups." Chinese medicine fumigation and washing is controlled ophthalmic ", Zheng Qingqian [periodical name] the healthy .2002 of PLA, (5). get fresh Herba Taraxaci 120 gram fumigation and wash method and suffer from eye treatment acute conjunctivitis; Get Folium Artemisiae Argyi, Cortex Phellodendri, Rhizoma Coptidis, each 5 gram of Semen Plantaginis, Alumen 2 grams with the cloth parcel, are fried in shallow oil soup, and fumigation and wash method is suffered from eye treatment blepharitis while hot; Adopt Alumen, Chalcanthitum, each 3 gram of Rhizoma Coptidis, Herba Equiseti Hiemalis's 6 grams, decocting is got fumersion and is washed and suffer from the eye treatment and soak into and carry out phase trachoma; Adopt Folium Mori, Flos Chrysanthemi, each 15 gram of Flos Lonicerae, Rhizoma Coptidis, Radix Saposhnikoviae, Radix Angelicae Sinensis, each 9 gram of Radix Paeoniae Rubra, after adding decocting and enduring, filter and remove residue, fumigation and wash method is suffered from the g county.Each 15-20 minute, every day 2-3 time, 3 was 1 course of therapy hordeolum.In addition, Chinese technical journal has also been reported with two five soup and has been washed the eye treatment children's disease of shedding tears, cleaned oculopathy etc. with tea, Flos Chrysanthemi solution.
Above-mentioned collyrium has certain curative effect to the treatment of some ophthalmic, but the composition more complicated of Chinese medicine digestion liquid generally is not an isosmotic solution, the yet not necessarily suitable eye table environment of the acid-base value of solution, therefore usually the stimulation to the eye table is bigger in use, causes ophthalmic uncomfortable.
Summary of the invention
The inventor after research and testing, invented a kind of discomfort that can alleviate eyes, to eye table microenvironment have the improvement effect, can the unclean secretions of flush away and remove pathogenic microorganism, help the metabolic eye washing eye liquid that makes eye bright of a normal physiological of table organization's cell.
The raw material of the eye washing eye liquid that makes eye bright of the present invention and composition be based on normal saline and Margarita hydrolyzed solution, taurine, adds some antibacterial antiseptic and some have the nutrient substance of health-care effect to eye table organization cell.Its quality percentage composition is as follows:
Margarita hydrolyzed solution 5-50%
Taurine 1-5%
Antibacterial antiseptic 0.2-2.0%
Nutrient substance 0.1-5.0%
The normal saline surplus
The total protein content of above-described Margarita hydrolyzed solution is greater than 1mg/ml, and the finished product total protein content is at 0.001mg/ml-50mg/ml.
Above-described normal saline is selected from phosphate buffered saline or borate buffer saline solution, and concentration is 0.1-0.2M, pH6.8-7.0.
Above-described antibacterial antiseptic is selected from some chloromycetin, chlortetracycline, chlorobutanol, benzalkonium chloride, chlorhexidine acetate or other antibiotic.
It is above-described that eye table organization cell is had the nutrient substance of health-care effect is vitamin A, vitamin C and hyaluronate sodium, chitosan.
The preparation method that makes eye bright eye washing eye liquid of the present invention is to add antibacterial antiseptic and eye table organization cell is had nutrient substance, Margarita hydrolyzed solution, the taurine of health-care effect in normal saline, all after the dissolving, and sterilization or filtration sterilization, encapsulation obtains product.
The composition effect of the eye washing eye liquid that makes eye bright of the present invention is as follows:
Margarita hydrolyzed solution mainly is that Margarita or Margarita layer powder form through refining, Margarita has tranquilizing mind, yin nourishing is flame-out, heat clearing away tunnel expectorant, blood stasis removing makes eye bright, the function of removing toxic substances and promoting granulation, be exactly the valuable ingredients of traditional Chinese medicine since ancient times, through the science and technology analysis, 16 kinds of inorganic elementss are arranged, based on calcium carbonate, inferior is calcium, sodium, the chemical compound of magnesium contains 16 seed amino acids in its keratin, content with alanine and sweet hydracid is higher, inferior is aspartic acid, leucine and arginine, modern pharmacology studies show that Margarita has slow down aging, antioxidation, the effect of antitumor action and promotion wound surface granulation hyperplasia.Margarita powder suspension lumbar injection can make the lipofuscin content of mouse cardiac muscle and cerebral tissue obviously reduce.Total porphyrin composition that extracts from Margarita and PFC etc. can suppress radical reaction, also can remove oxygen-derived free radicals in the body.The present invention adds Margarita hydrolyzed solution, can the nutrition eyeball, and reducing swelling and alleviating pain. tranquilizing mind, yin nourishing relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and effects such as removing toxic substances and promoting granulation have antiinflammation to eye conjunctivitis.
Taurine, chemical name is a 2-aminoethyl sulfonic acid, is the sulfonic acid analog of Beta-alanine, and is soluble in water, biotic factor is down many to be existed with zwitterionic form, gains the name because of separating from Fel Bovis seu Bubali first in 1827.Found taurine in 1954 in brain and spinal cord, Hayes in 1975 etc. report young cat because of shortage taurine visual deterioration in the food, even blind.In the world taurine has been carried out broad research later on, found that it is the important substance of regulating normal physiological function.Many studies show that, taurine has tangible lipoid peroxidization resistant as a kind of essential amino acid of human body.Biofilm system contains abundant unsaturated fatty acid, generates malonaldehyde under free radical and other oxygen initiator effects, and malonaldehyde can make memebrane protein, enzyme generation cross-linking reaction, make its structure, function impaired, enzymatic activity changes, and receptor inactivation on the film causes metabolism, function, structural change.Taurine comprises glutathion (GSH) content, antioxidase superoxide dismutase (SOD) and glutathion peroxidase (GSH-Px) activity to the influence of anti peroxidation of lipid, and aspect such as malonaldehyde (MDA) level variation.After Li Liangming found that rat power exhausts motion, the MDA of cerebral tissue significantly increased, and SOD and GSH significantly descend, and supplementation of taurine can make HOA significantly reduce, and stoped SOD to descend, and keep the GSH level, and the time that the power of moving to is exhausted had prolongation slightly.There are some researches show that taurine can stop Ovum Gallus domesticus Flavus lecithin to be oxidized to lipid peroxide, its mechanism may be relevant with the aldehyde radical reaction with taurine.Eye washing eye liquid of the present invention can increase aminoacid after adding taurine, and the nutrition eyeball can play antiinflammatory action.
Vitamin A, C and hyaluronate sodium, chitosan be a kind of have etc. ooze isobaric electrolyte solution or colloidal substance, for the regeneration of eye table organization cells physiological and pathologic reparation provide good microenvironment, its objective is to the normal physiological function of safeguarding eyes provides a kind of nutrition health-care functions.
The specific embodiment
Embodiment 1
In the phosphate buffered saline (pH6.8-7.0) of 100 milliliters of 0.1M, add chlorobutanol 0.25 gram; 5 milliliters (total protein content of Margarita hydrolyzed solution is greater than 1mg/ml for Margarita hydrolyzed solution; the finished product total protein content is at 0.001mg/ml-50mg/ml); taurine 200mg; all after the dissolving; sterilization, encapsulation obtains product.
Embodiment 2
In the phosphate buffered saline (pH6.8-7.0) of 100 milliliters of 0.2M, add benzalkonium chloride 0.2 gram; 10 milliliters (total protein content of Margarita hydrolyzed solution is greater than 1mg/ml for Margarita hydrolyzed solution; the finished product total protein content is at 0.001mg/ml-50mg/ml); taurine 500mg; all after the dissolving; sterilization, encapsulation obtains product.
Embodiment 3
In the phosphate buffered saline (pH6.8-7.0) of 100 milliliters of 0.1M, add hyaluronate sodium 0.2 gram; 15 milliliters (total protein content of Margarita hydrolyzed solution is greater than 1mg/ml for Margarita hydrolyzed solution; the finished product total protein content is at 0.001mg/ml-50mg/ml); taurine 200mg; all after the dissolving; sterilization, encapsulation obtains product.
Embodiment 4
In the phosphate buffered saline (pH6.8-7.0) of 100 milliliters of 0.15M, add chloromycetin 0.25 gram, 30 milliliters of Margarita hydrolyzed solutions, taurine 300mg, vitamin A 0.3 gram, after all dissolving, sterilization, encapsulation obtains product.
Embodiment 5
In the phosphate buffered saline (pH6.8-7.0) of 100 milliliters of 0.15M, add chlorhexidine acetate 0.3 gram; 45 milliliters (total protein content of Margarita hydrolyzed solution is greater than 1mg/ml for Margarita hydrolyzed solution; the finished product total protein content is at 0.001mg/ml-50mg/ml); taurine 250mg; vitamin A 0.3 gram all after the dissolving, is sterilized; encapsulation obtains product.
Embodiment 6
In the phosphate buffered saline (pH6.8-7.0) of 100 milliliters of 0.1M, add chlortetracycline 0.5 gram; 50 milliliters (total protein content of Margarita hydrolyzed solution is greater than 1mg/ml for Margarita hydrolyzed solution; the finished product total protein content is at 0.001mg/ml-50mg/ml); taurine 500mg; vitamin C 0.3 gram all after the dissolving, is sterilized; encapsulation obtains product.
Embodiment 7
In the borate buffer saline (pH6.8-7.0) of 100 milliliters of 0.15M, add chloromycetin 0.25 gram, 30 milliliters of Margarita hydrolyzed solutions, taurine 300mg, low-molecular-weight chitosan 0.3 gram, after all dissolving, sterilization, encapsulation obtains product.
Embodiment 8
In the borate buffer saline (pH6.8-7.0) of 100 milliliters of 0.15M, add chlorhexidine acetate 0.3 gram; 45 milliliters (total protein content of Margarita hydrolyzed solution is greater than 1mg/ml for Margarita hydrolyzed solution; the finished product total protein content is at 0.001mg/ml-50mg/ml); taurine 250mg; hyaluronate sodium 0.3 gram all after the dissolving, is sterilized; encapsulation obtains product.
Clinical experiment report
From January to 2002 calendar year 2001 year December end, the inventor is dried with the own eye washing eye liquid treatment sand holes that make eye bright, acute catarrhal conjunctivitis, ophthalmalgia, eye acid, the eye of producing, blurred vision, symptom such as shed tears, and has obtained significant curative effect and has been reported as follows: 1 data and method
Observe case and be the out-patient, by 50 examples, matched group 30 examples see Table 1
Table 1, two groups of case data relatively
The group case load mean age (year) the average state of an illness (my god)
Observation group 50 32 2
Matched group 30 29 2
The mean age of two groups of cases, average course of disease and sex ratio, difference does not have significance.
Diagnostic criteria: according to Ministry of Public Health " new drug (Chinese medicine) clinical research guideline " and " ophthalmology of Chinese medicine 〉. " tcm clinical research guide " formulates diagnostic criteria; 1. morbidity is anxious, and it is ill mostly to be eyes, and contact history is arranged; 2. subjective symptoms: foreign body sensation, photophobia is shed tears, and the margo palpebrae up and down that has has secretions withered, blurred vision; 3. examination of eyes: eyelid is red, the conjunctival congestion that has, and edema, or with point, lamellar subconjunctival hemorrhage;
Include standard in: 1. meet above-mentioned diagnostic criteria; 9. in age 10-60 year, 3. do not have cardiovascular and cerebrovascular vessel, liver, kidney and disease of hematopoietic system, disease is a cup too low.
Exclusion standard: 1. gestation or women breast-feeding their children; 7. the relevant medicine of life-time service drug withdrawal person immediately; 3. not medication in accordance with regulations can't be judged the uneven person of curative effect or data.
Observational technique: offer thematic outpatient service.J regularly checks by special messenger's observed and recorded, strict control medication.Eye is washed with eye washing eye liquid of the present invention by observation group, at first with this liquid secretions is rinsed well reuse eyebath dress.
2 results
Criterion of therapeutical effect: cure; Subjective symptoms and local inflammation disappear.The hyperemia of eyelid bulbar conjunctiva is disappeared, and subconjunctival hemorrhage absorbs the c produce effects: subjective symptoms and local inflammation are clearly better, and the near miss conjunctival congestion is most of to be absorbed.Effectively; Subjective symptoms and local inflammation take a turn for the better, congested most of absorption of conjunctive bulbi.Invalid: subjective symptoms and local inflammation no change.
Total effects sees Table 2, X
2=2.93, P＜0.01, difference has significantly
Treatment group curative effect obviously is better than matched group.
Table 2 liang group curative effect relatively
Group recovery from illness produce effects enabledisable is always effective
Eye number % eye is counted the % eye and is counted the % eye and count % and lead (%)
Two groups 38 34.14 50 58.04 15 11.82 00 100 of examining
Matched group 10 12.99 28 36.36 32 41.56 7 9.09 91
Discuss
Originally the eye washing eye liquid that makes eye bright can be treated ophthalmic, this medicinal liquid clearing away heat to improve acuity of vision, itching-relieving action, tomorrow nebula removing, removing toxic substances and promoting subsidence of swelling, calmness is especially to staphylococcus aureus. and Staphylococcus albus, bacillus pyocyaneus etc. has stronger antibacterial action, and the viewing duration end finds that the patient has untoward reaction.
Claims (2)
1. preparation method of eye washing eye liquid that makes eye bright; it is characterized in that: be the nutrient substance that in normal saline, adds Margarita hydrolyzed solution, taurine, antibacterial antiseptic and eye table organization cell is had health-care effect by the quality percentage composition; all after the dissolving; sterilization; encapsulation obtains, and each material composition and quality percentage composition are as follows:
Margarita hydrolyzed solution 5-50%;
Taurine 1-5%;
Antibacterial antiseptic 0.2-2.0%;
Nutrient substance 0.1-5.0%;
The normal saline surplus;
Described normal saline is selected from phosphate buffered saline or borate buffer saline, and concentration is 0.1-0.2M, pH6.8-7.0;
Described antibacterial antiseptic is selected from chloromycetin, chlortetracycline, chlorobutanol, benzalkonium chloride or chlorhexidine acetate;
Described nutrient substance is the nutrient substance that eye table organization cell is had health-care effect, selects wherein a kind of or mixture of vitamin A, vitamin C and hyaluronate sodium, chitosan for use;
Wherein make eye bright the total protein content of eye washing eye liquid finished product at 0.001mg/ml-50mg/ml.
2. the product that the preparation method that makes eye bright eye washing eye liquid as claimed in claim 1 obtains.
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| CNB2004100126129A CN100423731C (en) | 2004-01-01 | 2004-01-01 | Eye brightening eye washing liquid and its preparation method |
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| CNB2004100126129A CN100423731C (en) | 2004-01-01 | 2004-01-01 | Eye brightening eye washing liquid and its preparation method |
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| CN100423731C true CN100423731C (en) | 2008-10-08 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100453086C (en) * | 2006-06-22 | 2009-01-21 | 武汉远大制药集团有限公司 | Gel for removing ocular by ice pearl and its preparation |
| CN106265797A (en) * | 2016-09-18 | 2017-01-04 | 成都测迪森生物科技有限公司 | A kind of collyrium |
| CN107913202A (en) * | 2017-09-29 | 2018-04-17 | 上海雨淑缇化妆品有限公司 | A kind of eyeball bright eyes conditioning nutrient solution and preparation method thereof |
| CN111778117A (en) * | 2019-05-21 | 2020-10-16 | 何凡 | Preparation method of antiviral biological peptide care solution |
| CN116850245A (en) * | 2023-08-22 | 2023-10-10 | 陕西东健药业有限公司 | Deuterium-depleted water traditional Chinese medicine combined eye care solution and preparation method thereof |
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| CN1112435A (en) * | 1994-09-10 | 1995-11-29 | 国家环境保护局南京环境科学研究所 | Potent pearl eye drops |
| CN1126076A (en) * | 1995-03-11 | 1996-07-10 | 苏州市水产研究所 | Pearl liquid for improving eyesight |
| CN1215588A (en) * | 1997-10-23 | 1999-05-05 | 刘伟中 | Multifunctional health eye moistening atriphos liquid and preparing method thereof |
| CN1367004A (en) * | 2002-01-21 | 2002-09-04 | 王允奎 | Medicine for curing cancers |
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2004
- 2004-01-01 CN CNB2004100126129A patent/CN100423731C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1112435A (en) * | 1994-09-10 | 1995-11-29 | 国家环境保护局南京环境科学研究所 | Potent pearl eye drops |
| CN1126076A (en) * | 1995-03-11 | 1996-07-10 | 苏州市水产研究所 | Pearl liquid for improving eyesight |
| CN1215588A (en) * | 1997-10-23 | 1999-05-05 | 刘伟中 | Multifunctional health eye moistening atriphos liquid and preparing method thereof |
| CN1367004A (en) * | 2002-01-21 | 2002-09-04 | 王允奎 | Medicine for curing cancers |
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