CN100399987C - Method of dynamic detecting organism parameter and its medical detecting analyzer - Google Patents

Abstract

The present invention relates to a dynamic organism parameter detecting method and a medical detecting analyzer thereof. A microwave heating element, a microwave guide pipe, a temperature measuring element and a display screen control unit are mainly arranged in an outer shell, wherein the microwave heating element is used for providing a heat source for heating detected skins and deep tissues, a semiconductor preheating-precooling pipe is sheathed on the outer wall of the microwave guide pipe, the inner wall of the microwave guide pipe is covered with an insulation film and is provided with a stop block, a formed detecting hole is used for guiding microwaves so that the microwaves directly act on skins and deep tissues, the temperature measuring element is used for monitoring temperature and transmitting the characteristic values of temperature changes to a central chip, an externally connected infrared thermal image temperature probe is arranged at the inner end of the microwave guide pipe and is slightly projected out of the inner wall of the pipe, and a cooling fan, the central chip and a display screen are connected with the display screen control unit. The present invention has the advantages that organism parameters are detected in the dynamic, safe, reliable and correspondingly simple manner at a high speed without the generation of wounds, the detecting expenses are low, human bodies bear radiation at a low level, and the shapes of pathologic change regions and the sites of organism abnormity can be determined at a high speed.

Description

The medical detecting analyzer of detection of dynamic body parameter

(1), technical field

The present invention relates to a kind of medical inspection device that detects organism parameter.

(2), background technology

Medical development has many medical detection methods and equipment and is invented and develop so far.Single is example with imaging class technology, present widely used just have X ray transmission and CT, ultra sonic imaging, nuclear magnetic resonance (MRI), radioisotope tomography (ECT), single photon emission tomographic imaging (SPECT) and positron emission tomography multiple means such as (PET).Though these technology are improved day by day and be ripe, some inherent shortcomings are still fettering further developing of they.Such as the injury problem of X ray to human body, the resolution problem of ultrasonoscopy, MRI, the cost of PET and testing cost problem, most of technology can only provide static anatomical structure or stripped Biochemical Information, and problem of dynamic function information or the like can not be provided.This just impels people constantly to propose new detection method, develops new equipment to address these problems.

Adopt other harm electromagnetic wave few to carry out the selection that medical detection is many inventors than X ray.United States Patent (USP) 08/250762,60/047604,60/021284 proposes a kind of microwave chromatographic imaging system, and it adopts the microwave of certain wavelength that organism is scanned, and the microwave of transmission is carried out analyzing and processing, finally obtains three-dimensional tissue image.Because the depth of microwave penetration of wavelength weak point is limited, the long microwave resolution of ripple is not high, so microwave tomography method has its limitation.The Chinese patent (application number 1009840) in addition that other adopts microwave to detect, proposition obtain the method for moisture content of lung with the variation of analyzing microwave penetration lung front and back.Chinese patent (application number 89102298) proposes a kind of passive microwave diagnostic apparatus of being made up of thermal information extraction part and information processing system, adopt the spiral of Archimedes probe good with the tissue impedance matching, receive circular polarisation or elliptically polarised wave in the 2.25-2.65GHz frequency range, in order to survey the effective information of human body deep tissue tumor.

Japan Patent 37276/2002 proposes to use the transmission of near infra red light organism, and the mode by the analyzing and processing transillumination obtains tissue metabolism's information such as hemoglobin.This is a kind of local detection means.Adopt the patent of fluorescent technique to have much.Propose a kind of fluorescence spectrum cancerous diagnose device and method as Chinese patent (application number 01142855), the diagnostic method of this device is that cancer patients serum or soft tissue position are made fluorescence spectrum figure and carry out fluorescence analysis.Whether Canadian Patent 2126915 proposes a kind ofly to utilize infrared spectrum analysis to survey unusual method in antiseptic, nature or fresh biological tissue artificial culture, that comprise exfoliative cyte or cell sample, absorbed to change by infrared spectrum unusually and decide.Chinese patent (application number 200310107677) discloses a kind of diode laser laser spectrum cancer diagnosis instrument.It uses diode laser as excitation source, when laser by fiber-optic illuminated on tissue the time, the fluorescence that is sent returns along former road by optical fiber again, utilize ccd detector to receive the fluorescence of corresponding light spectral limit, the fluorescence spectrum that shows the wave band of wanting by computer, be analyzed then, obtain the information of wanting.

Except the infrared image and liquid crystal method of body surface cancer tissue surveyed in common being used for, the patent that a class utilizes infrared imaging to detect the body deep anomalies also was suggested.Chinese patent (application number 02133987) proposes a kind of so-called infrared perspective method.It is the infrared ray that the heat energy information via body surface heat energy rank with a certain tomography of human body thermal field are given off, and passes through frame scan successively.Behind line scanning and optical system, the frequency-division filter, focal imaging is in detector and convert analog electrical signal to, this analog electrical signal is transported in the computer become digital electric signal after processing and amplifying, analog-digital converter conversion after, and computer shows this signal does not change temperature to change colour principle with special-purpose software through pseudo-colours.Obvious this method is not really to see through human body with infrared ray to come imaging, the method that its novelty obviously proposes not as class United States Patent (USP) 6023637.The method that the latter proposes is by scanning human body position to be detected, obtains the infrared intensity data, the color that different intensity level is corresponding different.These intensity levels should be in one to have within minimum and the peaked input window.Define an output window in this window again, the maximum of output window should be less than or equal to the maximum of input window, and its minima should be more than or equal to the minima of input window.By these two windows data are handled, the heat radiation that human body depths tissue is produced also can be showed, finally obtains the hot faultage image of tissue.This technology is called as TTM (thermal texture maps) now, and its major advantage is not launch any ray (being passive detection), only needs just can obtain the dynamic function information of tissue by handling infrared image.Its weak point is the accurate form that is difficult to obtain abnormal structure's (as cancer), and structure and position in this respect not as CT or ultrasonic, although can be used as their means of supplementing out economy, in some aspects, in the breast carcinoma generaI investigation, are applied.Tracing it to its cause, is because of the temperature difference between abnormal structure or position and normal structure or the position is little generally speaking, if abnormal structure or position are positioned at body surface, shows by Infrared Thermogram or liquid crystal figure easily.If but be positioned at the body depths, because heat conducting effect, this small temperature difference just becomes littler when passing to body surface, and the boundary of high-temperature region and low-temperature space is just fuzzyyer, the form at abnormal structure or position is just very inaccurate on the thermography, and its center also is difficult to determine.

Physiological or pathologic temperature difference that Chinese patent (application number 02159137) proposes to use a kind of temperature contrast medium to make the target site of detection be adjacent the position enlarge, thereby improve the heat picture contrast that target site is adjacent the position.This temperature contrast medium should be the reagent that does not pharmaceutically have toxic side effect.United States Patent (USP) 200100-46471 also proposes to adopt a kind of chemical compound, but it is thermographic contrast before and after using by chemical compound, obtains the usefulness that chemical compound changes the blood thermodynamic property.Obviously, the temperature difference that adopts biochemical means (as special medicament) to improve between certain specified abnormal structure or position and adjacent tissue or the position is the quite work of difficulty.

At present, produce acting on the electromagnetic wave technology that human body, its intensity and frequency all be controlled in the harmless scope increasingly maturely, many equipment are the marketization.But these technology and equipments all are to be used for the organism disease treatment.Such as various microwave therapy apparatuses is exactly to adopt contact or discontiguous different irradiator the human body disease sites to be applied the microwave of lasting or impulse form, utilize its effect hot and non-heat to reach and make the tissue blood vessel expansion, permeability of cell membrane improves, improve Nutrition and Metabolism, promote tissue regeneration and spasmolytic, relieve the pain and purpose such as antiinflammatory.Conventional frequency is from 10MHz to 2,450MHz, and power bracket mostly is 10 to 30 minutes action time from tens of to hundreds of watt.But for the situation of killing cancerous cell with high temperature, the power requirement of microwave is bigger, generally needs action time to continue more than 40 minutes, and the temperature that can make the canceration position just was elevated to more than 42.5 ℃ rapidly in begin to heat 10 to 15 minutes.

At present, both at home and abroad the detection method about blood glucose has wound property mostly, adopts determination of glucose oxidase again after promptly need extracting blood samples of patients.Vein whole blood, blood plasma or serum glucose detect and carry out in hospital, and the capillary tube full blood glucose detects available small-sized blood glucose meter and tested oneself by patient.For reaching ideal glycemic control target, must carry out repeated detection in one day, comprise three at least before the meal, the back and sleep before.Be suspected to have hypoglycemia at night, also need add survey.Though this class methods accuracy rate height also has inevitable shortcoming.At first be repeatedly to draw blood repeatedly every day to bring very big misery,, all need expensive glucoseoxidase reagent or reagent paper, so testing cost can cause the bigger financial burden of patient no matter secondly be in the hospital or the self check of being in to patient.In addition, be in that self check may produce also that blood sampling is polluted and problems such as bacterial infection.It is perspiration and the tissue fluid of extracting the finger surface earlier that at present unique in the world commercial non-invasive detects, and the reuse glucose oxidase method detects blood sugar concentration wherein.Japan Patent (2004-003826, Chinese application number 200410081808) proposes a kind of extractor of subcutaneous tissue liquid, and behind the extraction hole extraction secretions that only passes keratodermatitis, the reuse enzyme process detects.The shortcoming one of these class methods is that precision is difficult to guarantee, the 2nd, and complex structure, the problem of also unresolved dependence glucoseoxidase simultaneously.

Malignant tumor (generalized cancer) is the most serious a kind of disease of harm humans health.Its mortality rate is only second to cardiovascular disease.Cancer patient's number is fast rise just year by year.The most important measure that reduces cancer mortality is exactly to find as early as possible, in time treatment.But detecting of early stage cancerous issue is very difficult, not only depends on the sensitivity and the reliability of detecting instrument, also depends on testing staff's experience and knowledge, and it is all multifactor also to design testing cost etc.With breast carcinoma is example, early stage and non-evident sympton, and patient oneself is difficult to discover.Tumor markers lacks specificity and sensitivity at the beginning of forming.Cytolgical examination is only used under the situation that occurs nipple discharge.Biopsy also is just to consider to carry out in the time of need having manifest symptom to occur.Imaging examination is main means with the film making of aluminum target X ray still at present, but can it improve early-stage breast cancer investigation rate, has been subjected to extensive query at present.American Cancer Society has advised stopping using the generaI investigation means of the method as women's breast carcinoma.B ultrasonic has certain distinguishing ability for the lump in the fine and close body of gland.But generally be suitable for being not less than the focus of 2cm.The cold light transillumination is powerless for the cancerous tissue of depths slightly.The infrared thermal imagery diagram technology is to the experiment of breast carcinoma sensitivity, and existing report is not really consistent, and this is main because the information that thermography shows is fainter, and the height of recall rate depends on medical worker's experience to a great extent.

(3), summary of the invention

The medical detecting analyzer that the purpose of this invention is to provide a kind of detection of dynamic body parameter, by changing the mode of the temperature or the increase temperature difference, solve dynamically, noinvasive, fast, safety, detect the problem of organism parameter relatively simply reliably, again, and lower, less to the radiation of the human body detecting instrument of a kind of testing cost is made in solution, by detecting parameters such as organism temperature parameter and normal value, determine the shape of lesion region and the problem at the unusual position of body fast.

Technical scheme of the present invention:

The method of this detection of dynamic body parameter is characterized in that:

Make the corresponding rule-of-thumb relation of normal body position to be checked temperature change value and organism parameter in advance; Temperature element and microwave heating element are put on body detection position respectively, detection of dynamic or monitor the variations in temperature of this body area then, obtain the temperature information of position to be checked microwave band or infrared band, the temperature at position and the temperature difference between the adjacent normal region are surveyed in the machines health check-up, detected value is compared with corresponding rule-of-thumb relation, draw tested organism parameter value.

The wavelength of above-mentioned microwave heating element launching electromagnetic wave from 100m to 0.76 μ m, the especially scope from 1m to 1mm; Frequency of ultrasonic from 20kHz to 20MHz, the scope from 100kHz to 10MHz especially.

Above-mentioned electromagnetic wave or hyperacoustic power are shorter than 60 minutes action time less than 300W.

Above-mentioned microwave heating element acts on position to be detected, tissue or organ earlier, when reaching between ideal temperature or tissue during the temperature difference, begins temperature detection or monitoring with temperature element immediately.

The medical detecting analyzer of this detection of dynamic body parameter is characterized in that: outlet, on and off switch, detection hole, display screen, display lamp and computer interface are arranged on the shell, comprise following major part in the shell:

Microwave heating element:, be used to provide the thermal source of detected skin of heating and deep tissues by the microwave generator that comprises that magnetron, high voltage package and large bulk capacitance are formed;

Microwave plumbing: perpendicular to shell, microwave plumbing is inner to be connected with the microwave heating element, it is outside that the outer end mouth of pipe sees through shell, the microwave plumbing outer wall is with quasiconductor preheating-pre-cooling pipe, the microwave waveguide inside pipe wall is covered with dielectric film, and be provided with block, and form and detect the hole, be used to guide microwave to directly act on skin and deep tissues;

Temperature element 3: be used for monitoring temperature and transmit the variations in temperature eigenvalue to central die, external infrared thermal imagery temperature probe is located at the microwave plumbing inner end, protrudes in inside pipe wall slightly;

Cooling fan: be used for cooling, in order to avoid influence testing result next time;

Central die: be used for storage and can compile control sequence, send fill order and detect data contrast, calculating and processing automatically, comprising the control sequence that connects quasiconductor preheating-pre-cooling pipe and send fill order unit, date processing and memory element, A-D conversion and amplifying circuit, dc source circuit, data show control circuit, cooling fan control circuit, the preset temperature regulating circuit is connected with the preset temperature unit, is used for being provided with and increase and decrease adjusting preset temperature; Time adjustment circuit is connected with the time regulon, is used to adjust the length of microwave heating time; Power conditioning circuitry is connected with the microwave power regulon, is used to regulate the microwave intensity of input;

The display screen control unit that is connected with display screen: be connected with the output port of data show control circuit in the central die, be used to show detected value and detection time.

Above-mentioned detector is desk-top, portable or hand-held, its central die is connected with the data storage elements of clock and/or mobile phone, after detection is finished, be stored in the central die in the past the testing result in one period, can send to hospital or give the household for reference by mobile phone.

Above-mentioned microwave heating element is by the microwave generator that comprises that magnetron, high voltage package and large bulk capacitance are formed, or by the microwave generator that comprises that antenna, microwave receiving and control circuit are formed.

Above-mentioned microwave heating element is temperature sensor, infrared radiation thermometer, thermal infrared imager or microwave thermal imaging system.

Above-mentioned infrared radiation thermometer is the irradiator of a launched microwave, or gets final product launched microwave, can accept the difunctional irradiator of microwave again.

Above-mentioned microwave plumbing is rectangular tube, round tube or shape of a saddle pipe.

Instrument of the present invention changes the temperature of appointed part or the temperature difference between raising specified tissue (or zone) and the adjacent normal structure (or zone) with specific electromagnetic wave and ultrasound wave; adopt some thermometric degree; Infrared Thermogram or these variation of temperature of microwave thermal image pattern mode detection of dynamic; chromatographic technique that reuse is special and computer craze image pattern quantification treatment technology; obtain the dynamic temperature feature at the body different depth place that causes after the means of applying; find out representative parameter; and with the related data comparative analysis of calculator memory normal body or tissue, obtain unusual accurate information occurring by the body or the tissue of these parameter characterizations.Continue to carry out repeatedly as applying of means, also can obtain the dynamic function information of unusual or normal structure with obtaining of information.

The principle that electromagnetic wave and ultrasonic wave energy change the temperature difference between tissue temperature and the raising tissue is known.The heat effect of microwave is the most obvious in the electromagnetic wave.Microwave is the essence of organism thermal effect, the microwave radiation organism also is penetrated among the tissue, when this tissue because when absorbing heat that the microwave the subject of knowledge and the object of knowledge transforms and surpassing the heat that blood circulation and conduction of heat take away, the accumulation that will produce heat causes that partial thermal ataxia and temperature rise.The skin of organism, muscle, fat and each internal organs all are by the polarity protein molecular, and polar water molecules and inorganic ion are formed, and they all are made up of the atomic nucleus and the electronegative electronics of positively charged.Do not have when adding electromagnetic field, all arrange, be in poised state by specific forms and rule.When adding electromagnetic field, Biomedia promptly interacts with electromagnetic field, and following state occurs: mutation appears in (1) polar molecule, and electron displacement polarization promptly takes place.This polarization obtains energy from electromagnetic field at any time, correspondingly changes polarised direction by the alternating electromagnetic field rule, thereby the loss microwave energy is converted into heat energy.(2) polar molecule all has certain dipole moment.Add outside under the electromagnetic field effect, will rearrange, and vibrate back and forth, collide mutually with adjacent molecule simultaneously, aggravated the confusion motion of these molecules, increased heat with electromagnetic field.(3) add under the electromagnetic field effect, ion is quickened and is produced mobilely, produces heat with adjacent molecule collision.But because the component and the structure of each organ or tissue of organism have certain difference, especially the moisture content difference is bigger, thereby calorifics is different with electric property, causes the thermal effect of microwave very big difference may occur.Experiment shows that microwave has following electrical characteristics at Fu Shui tissue (in skin and muscle):

Wavelength cm penetration depth cm in frequency MHz DIELECTRIC CONSTANT H electric conductance σ H (S/M) tissue

10 160 0.602 118 21.6

27.12 113 0.625 68.1 14.3

40.68 97.3 0.680 51.3 11.2

433 53 1.18 8.76 3.57

915 51 1.28 4.46 3.04

2450 47 2.17 1.76 1.70

By contrast, the electrical characteristics of microwave in weary water tissue (as fat and skeleton) have a great difference:

Wavelength cm penetration depth cm in frequency MHz DIELECTRIC CONSTANT H electric conductance σ H (S/M) tissue

27.12 20 10.9-43.2 241 159

40.68 14.6 12.6-52.8 187 118

433 5.6 37.9-118 28.8 26.2

915 5.6 55.6-147 13.7 17.7

2450 5.5 96.4-213 5.21 11.2

From above-mentioned data as can be seen, because moisture difference, under the microwave action of same frequency, dielectric constant between the tissue or electrical conductivity can differ nearly ten times.So in the rich water tissue, the loss of microwave will be much higher than the loss in weary water tissue.In other words, under the same microwave action, the temperature of Fu Shui tissue raises and organizes much obvious than weary water.Here it is, and microwave causes occurring between different tissues the reason of the temperature difference.The far infrared wave that other electromagnetic wave, especially wavelength are a bit larger tham microwave near the ultrashort wave and the wavelength of microwave, they cause the living organism temperature to raise and tissue between the mechanism that increases of temperature difference basic identical.

Because the electromagnetic wave radiated element that the present invention adopts only is used to make the temperature at a certain position of body suitably to raise or makes the temperature difference between tissue reach certain level, so, have following characteristics than existing microwave or other electromagnetic wave equipment that is used for the treatment of function:

One. power demand is little, is generally less than 300W.

Two. action time is not long, generally is shorter than 10Min, adopts the continuous schedule emission usually, does not adopt the pulsed radiation pattern.

Three. used frequency or wavelength depend on the degree of depth of position to be detected or tissue.The degree of depth is dark more, frequency should be low more or wavelength should be longer.Such as detection, should use the decimetric wave of frequency 460MHz for depths breast carcinoma.Otherwise, for the position or the tissue of shallow table, the electromagnetic wave that usable frequency is higher or wavelength is short slightly.

Four. for the chromatographic technique of realizing that the back will be narrated, the frequency of electromagnetic wave emission or power or action time should be accurately, adjust in a big way at one easily, change and control.

Five. used microwave generator is relevant with the shape of position to be detected or organ.For microwave, because of dispersivity is big, need be with special system during transmission, it generally is made up of microwave plumbing (or coaxial cable) and the different irradiator of shape and structure that is attached thereto.The size and dimension of irradiator can with the frequency resonance of microwave generator, the emission port of irradiator can be complementary with the shape of position to be detected or organ.Such as being used to make the finger end region temperature to raise detecting the situation of blood glucose, emission port can be designed to finger size match cylindric.For the situation that detects breast carcinoma, emission port can be designed to than the hemispherical big slightly with breast size.For the detection waist, the situation of breast abdominal part, can be designed to the bigger opening of area is saddle-shaped irradiator.

Six. during use, irradiator and position to be detected, tissue or organ can directly contact, and also can keep certain distance, and generally from 1 to 20 centimetre, middle available air is made medium, also can be every the underwear to approach.As with absorbing very little material (as quartz sand) filling body of microwave energy and the gap between the irradiator, can reduce microwave and in air, reflect and scattering, improve the microwave utilization rate.

Seven. consider the interference of electromagnetic wave to back temperature detection device (temperature sensor or thermal imaging system etc.), common two processes are separately carried out.Promptly earlier act on position to be detected with electromagnetic wave, tissue or organ when reaching between ideal temperature or tissue the temperature difference, stop the electromagnetic wave effect, begin temperature detection or monitoring immediately.Obtain the multidate information of body tissue if desired, above-mentioned two step processes can be carried out repeatedly, promptly press: apply electromagnetic wave, and----temperature detection----carry out by the pattern that applies electromagnetic wave----temperature detection.Under the particular case, be not subjected to Electromagnetic Interference as temperature sensor, the then above-mentioned process that was divided into for two steps can be carried out simultaneously, Yi Bian promptly apply electromagnetic wave, Yi Bian detect or monitor the temperature variation effects that electromagnetic wave causes.

Eight. in order to save the device space and to simplify the operation, irradiator can be designed to get final product launched microwave, can accept the double-function device of microwave again.Promptly, treat that the temperature or the temperature difference reach after the requirement, switch to the microwave accepter immediately, and can carry out this switching repeatedly earlier as microwave emitter.

The principle that ultrasound wave changes the temperature difference between tissue temperature and the raising tissue is as follows.Ultrasonic when propagating in Biomedia, its energy can be absorbed and be converted into heat energy.Main transforming machine is shaped on the energy absorption that (1) takes place owing to the relaxation phenomenon of medium molecule power conversion, and is relevant with the characteristic and the supersonic frequency of medium itself.The former influences relaxation time and allocation proportion that kinetic energy and other form of energy transform mutually because of the microstructure of medium 2 and the difference of physico-chemical property.Phase place and amplitude when the latter influences energy reduction microwave kinetic energy.In biological living, macromole (mainly being protein) accounts for consequence to ultransonic absorption, and its absorption characteristic is relevant with the relaxation process of conversion with intermolecular energy transmission with intramolecularly.So the ultrasonic absorption coefficient of biological tissue and the relation between the supersonic frequency are complicated.The ultrasonic energy overwhelming majority that biological tissue absorbs will be converted to heat energy, cause the rising of tissue temperature.When supersonic frequency was the moderate strength of number megahertz, heat effect in the highest flight.In soft tissue, the gross energy of absorption has 80% to be because the relaxation process of protein molecule power conversion causes.(2) alternative pressure changes when ultrasound wave passes through medium, makes the histiocyte periodic compression, causes that temperature raises.(3) reflection of ultrasonic energy on the different tissues interface causes particle because of standing wave forms, the friction of particle and give birth to heat.Same because the component and the micro structure of each organ or tissue of organism have certain difference, just variant to the absorptance of acoustic energy.Heat effect under same ultrasonication has suitable difference, the ultrasonic reason that causes occurring between different tissues the temperature difference that Here it is.

Similarly, the ultrasonic therapeutic technology and equipment also reaches its maturity, and frequency commonly used has 8MHz, 1MHz and 3.2MHz.The sound head diameter has 1cm, specifications such as 2cm and 5cm.An important feature of ultrasonic utilization is: as adopt the direct way of contact to load, between sound head and body surface, just need to adopt couplant, to reduce acoustical energy losses.As adopt water as sound bearing medium, and then therapentic part should immerse under water fully, and sound head is also answered water-tight.Ultrasound detection and diagnosis are medically used in industrial using ultrasound flaw detection, all have been mature technique.But what the present invention proposed is to utilize the temperature of ultrasonic change appointed part or the temperature difference between the raising tissue, and the technology that is beneficial to detect still is brand-new trial.So compare the characteristics that oneself is arranged with existing ultrasonic device.

One. power demand is little, is generally less than 300W.

Two. action time is not long, generally is shorter than 10Min, adopts the continuous schedule emission usually, does not adopt the pulsed radiation pattern.

Three. when sound head maintained static, ultrasound intensity generally was not more than 1.5W/cm ²

Four. can adopt couplant to reduce acoustical energy losses.

Five. also can between sound head and body surface, adopt the water bag mode to reduce acoustical energy losses, the fully degasification of institute's water.Unsuitable water is as sound bearing medium.

Six. used sound head size and shape can design according to position to be detected or organ.

Seven. in order to save the device space and to simplify the operation, utilize the ultrasonic raising tissue temperature or the temperature difference, also using under the situation of ultrasound detection variations in temperature simultaneously, sound head can be designed to can launch ultrasound wave, can accept hyperacoustic double-function device again.Promptly, treat that the temperature or the temperature difference reach after the requirement, switch to the ultrasound wave accepter immediately, and can carry out this switching repeatedly earlier as ultrasonic transmitter.

Second core technology disclosed by the invention is to adopt various Non-Invasive temperature detection technology, and the difference variation state between variations in temperature behind the aforementioned physical means or specified tissue (or zone) and the adjacent tissue (or regional) is adopted at a certain position of detection of dynamic.So-called Non-Invasive temperature detection technology comprises:

One. adopt the temperature sensor detection of dynamic body surface measuring point variations in temperature that contacts with body surface.Contact temperature-measuring is conventional shell temperature detection technique.When using in the present invention, generally require at least one, best a plurality of temperature probes are rectilinear contacting with body surface simultaneously, by lead the temperature dynamic delta data input computer post analysis that obtains are handled.Require temperature probe that high sensitivity and precision are arranged, resolution is not less than 0.1 ℃.Pick off commonly used has critesistor, thermocouple, quasiconductor P-N knot and pierce oscillator.Temperature probe answers inspection to survey the size at position and undulations and design in the arrangement mode of body surface and density.If can carry out simultaneously for electromagnetic applying with the detection of temperature, should adopt the critesistor and the resistive conductor of high value or adopt the thermocouple of diameter less than 50 μ, other method is to use nonmetallic thermocouple, is equipped with superfine lead.But best bet is to adopt the liquid crystal optic fiber pick off, can not be subjected to electromagnetic interference fully.The mode of this some thermometric degree is applicable to position or the less situation of organ of detecting, such as situation about detecting in microwave irradiation defensive position finger ends variations in temperature, with regard to an available 3-5 thermoelectricity occasionally thermistor probe be arranged in finger tip and carry out detection of dynamic on every side.

Two. adopt non-contacting infrared radiation thermometer detection of dynamic or monitor the variations in temperature at position to be checked.The infrared radiation temperature instrument is the instrument that the far infrared section heat radiation that utilizes body surface to send carries out non-contact measurement, and generally by infrared fileter, lens and temperature-sensitive element (as thermoelectric pile or pyroelectric sensor) are formed.Compare with contact type temperature sensor, the response time of this radiation sensor is faster, and precision is also high, but is subject to the thermal-radiating interference of environment.When using in the present invention, generally also a plurality of infrared probes need be installed, should prevent the overlap problem of mutual surveyed area this moment.This kind mode also is only applicable to detect position or the less occasion of organ.As detecting when the microwave irradiation dynamic temperature situation of change of health one fritter skin.

Three. adopt non-contacting infrared thermal imagery diagram technology to obtain the temperature information of position to be checked infrared band.The infrared thermal imagery diagram technology is very ripe.Than infrared radiation thermometer, it makes the information of detection expand to face from point, thereby is more suitable for detecting the situation of larger area position or organ.Main imaging technique comprises optical scanning imaging and thermoelectric light guide imaging.The former precision height (scanning system resolution can reach 0.05-0.1 ℃).But the complex structure of equipment needs cooled with liquid nitrogen to reduce the thermal noise of detector itself.Latter's precision low slightly (ultimate resolution is 0.1 ℃).But at room temperature can operate, not need expensive cooling system, this external signal and video camera operating such, so the thermography of human body and video figure can overlappingly manifest, and locatees for diagnosis and bring convenience.Above-mentioned two quasi-instruments all can be directly used among the present invention the means as temperature detection on the large tracts of land position.But when surveying body deep anomalies zone, need additional special mechanical switching device, make the photographic head of thermal imaging system and irradiation of electromagnetic waves device above detecting the position, to be used alternatingly apace with chromatographic technique.In addition, with the supporting computer of thermal imaging system should be by the larger data memory space so that thermography carried out processing such as image recognition.

Four. adopt non-contacting microwave thermographic technique to obtain the temperature information of position to be checked microwave band.Microwave radiometer is to be used for detecting the thermal radiation signal of body in microwave range.Human body at the radiant energy of microwave section (wavelength is mainly from 30cm to 1mm) much smaller than radiant energy at infrared band (wavelength mainly from 8 μ m to 14 μ m).But because microwave wavelength is longer relatively, loss when propagating in medium is little than infrared ray, so the heat radiation that the body depths has the abnormal area of higher temperature to send is many in microwave band when arriving body surface, only fraction appears at infrared band, adopts microwave radiometer just can capture the more undesired information of multimachine body depths.Certainly, outside the heat extraction forms of radiation, the heat of body depths also can reach body surface by modes such as conduction and convection current, so also can obtain the temperature information of part depths with the infrared thermal imagery diagram technology, the so-called TTM method that aforesaid U.S. Patent that Here it is 6023637 proposes also can obtain the reason of body depths information.It at first is to adopt the active physical means to improve body to detect the temperature at position (or organ) or the temperature difference between amplification abnormal structure (or zone) and normal structure (or regional) that the maximum of the present invention and TTM method is distinguished.Next is to have adopted following chromatographic technique accurately to determine the position and the size in body deep anomalies tissue (or zone).This is that TTM is difficult to accomplish.The 3rd is to be not limited to only use the infrared thermal imagery diagram technology, and (especially when seeking body deep anomalies information) will use the microwave thermographic technique under the more situation.In the present invention, can adopt input that the microwave radiometer of the stable tunnel diode of the temperature characterisitic of 1-6GHz is housed, its resolution can reach 0.1 ℃.The antenna of accepting microwave can be contact or contactless, and the former grows (5-14cm) by wavelength, and latter's wavelength is lacked (0.4-3cm).As previously mentioned,, can be designed to accept microwave with accepting electric wire in order to save the device space and simplifying the operation, but the double-function device of launched microwave again.The machinery that so just can save additional converting antenna and irradiator.

The 3rd core technology disclosed by the invention is so-called chromatographic technique.In order to obtain the abnormal area information at body degree of depth position, need to adopt special analytical technology layer by layer (abbreviation chromatographic technique) from the body surface to the depths, its principle and step are as follows:

1. selected good body area (or organ) to be checked is taken thermography and is stored in this position and (is called Fig. 1) in the computer;

2. adopt electromagnetic wave to the heating of the layer tissue (being called first depth layer) in the certain depth (as 0-3mm) under this position body surface certain hour, this layer tissue temperature is elevated to a certain degree, if in the tissue abnormal area is arranged, because the difference of dielectric property, electromagnetic wave will make the temperature difference between abnormal area and normal structure amplify;

3. thermography (being called Fig. 2) is taken at this position, Fig. 2 and the Fig. 1 that is stored in the computer are compared, also the thermography of the normal structure that Fig. 2 and under similarity condition (identical electromagnetic wave parameter and take the degree of depth) can be taken is in advance compared, according to the temperature difference of amplifying, find out the temperature anomaly zone, and on camera plane, obtaining the two-dimensional coordinate of its size and central point, its degree of depth just should be in first depth layer.As do not find to continue the following step in the temperature anomaly zone;

4. this test section megadyne temperature degree recovers normally (not necessarily requiring to recover fully) substantially by the time, adopt electromagnetic wave to the heating of the layer tissue (being called second depth layer) in the more deep degree (as 0-6mm) under this position body surface certain hour once more, this layer tissue temperature is raise, and the temperature difference between abnormal area and normal structure is amplified;

5. thermography (being called Fig. 3) is taken at this position once more, Fig. 3 and Fig. 1 and Fig. 2 of being stored in the computer are compared, also the thermography of the normal structure that can take in advance with under similarity condition (identical electromagnetic wave parameter and take the degree of depth) is compared, according to the temperature difference of amplifying, find out the temperature anomaly zone, and on camera plane, obtain the two-dimensional coordinate of its size and central point, because no abnormal zone in first depth layer (0-3mm), so abnormal area at this moment just should be positioned at the scope that the depth capacity (6mm) of second depth layer deducts the depth capacity (3mm) of first depth layer, just under the body surface in the degree of depth of 3-6mm.As finding the temperature anomaly zone not yet, continue above-mentioned electromagnetic wave and heat-take thermographic step, up to the accurate position of finding out abnormal area or till determining this detection no abnormal zone, position (or organ).

In the process of implementing chromatographic technique, have several problems need the explanation: (1) as previously mentioned, when the body deep layer exists abnormal structure or when zone of the projecting normal structure of temperature, the heat in this zone can be by radiation, modes such as conduction and convection current reach body surface, so also can obtain the temperature information of a small amount of depths with common infrared thermal imagery diagram technology (as the TTM method).But abnormal structure or zone and the temperature difference on every side itself are with regard to little (generally the about 1-2 of the temperature difference ℃ of cancer cell tissue and normal structure), in the process of body surface conduction, because the heat diffusion in zone towards periphery and the flowing heat transfer of blood, when arriving body surface, this temperature difference is very small, and the relatively-high temperature district in former abnormal structure that shows or zone greatly enlarges, the shape of high-temperature region has produced great changes, so promptly enable to obtain the abnormal information of some deep layers, also very faint, the mistaken diagnosis probability is bigger, more is difficult to obtain the accurate position in abnormal structure or zone, size and dimension.Adopt method of the present invention, can be with deep layer abnormal structure or zone and the temperature difference of surrounding tissue amplification several times, so can in the thermography of body surface, know and show.When adopting chromatographic technique, because the top layer heated temperatures is higher, after passing to body surface, the heat in former deep layer abnormal structure or zone can not manifest, so can not influence the top layer thermography, can not cause the top layer that the false judgment of abnormal structure is arranged.(2) because the electromagnetic wave external inside emission of slave always, so along with the increase of electromagnetic wave depth of interaction, the temperature of textura epidermoidea also will improve, and be more near the tissue of body surface, the temperature rising is many more.This just makes the shown bulk temperature level of thermography of each depth layer of obtaining in the chromatography process increase gradually.The bulk temperature level that is earlier figures 2 is higher than Fig. 1, and the bulk temperature level of Fig. 3 is higher than figure two, and the like.So abnormal area is dark more, because corresponding thermographic bulk temperature level improves, the abnormal area that reflects on the thermography and the difference of surrounding tissue are just more little.(3) in the design of microwave oven, evenly same for food top layer and deep are heated, made full use of the characteristics that microwave is dispersed, the food rotation is heated.But in the present invention,, need avoid this scattering, must adopt the irradiator that is similar to microwave therapy apparatus, microbeam is hit in detecting position or organ, prevent energy spread in order to reach the purpose of accurate controlled microwave depth of interaction.(4) as previously mentioned, the microwave thermal image pattern more can reflect the information of body deep layer than Infrared Thermogram, so when using chromatographic technique to seek the deep unusual condition, adopt the microwave thermal image pattern more reasonable.(5) when adopting the microwave thermographic technique, can will accept Antenna Design for can accept microwave, but the double-function device of launched microwave again.

The degree of accuracy of the accuracy of above-mentioned chromatographic technique and abnormal area three-dimensional localization depends primarily on the accuracy and the precision of electromagnetic wave heat penetration control.For realizing this control, the present invention proposes following three kinds of measures:

1. keep power and action time constant, change the electromagnetic wave tranmitting frequency.As previously mentioned, electromagnetic wave (as microwave) frequency is high more, same power, and under action time and the body tissue condition, the degree of depth that electromagnetic wave penetrates is shallow more.Effective depth such as decimetric wave (460MHz) can reach 7-9cm, and far infrared just can only work to the degree of depth of top layer 1-2mm.But make electromagnetic wave launcher change tranmitting frequency easily and be not easy.Especially require conversion frequency very subtly, technical acquiring a certain degree of difficulty.

Holding frequency and action time constant, change the electromagnetic wave transmitting power.Under the constant situation of other condition.Electromagnetic wave power is low more, and the degree of depth that acts in tissue is shallow more.Because the mode by the changing input AC electricity frequency accurately technology of control and conversion microwave output power is very perfect, uses among the present invention and should be out of question, so be one of feasible measure.But need experiment to obtain the accurate relation between the microwave action degree of depth and power in the various tissues.

3. holding frequency and power are constant, change electromagnetic wave action time.A large amount of experiments of inventor show that action time is short more, and the degree of depth that electromagnetic wave reaches is just shallow more.But the degree of depth and time are not linear relationship, need strict experiment just can obtain electromagnetic wave depth of interaction and the accurate relation between the time in the various tissues.List the part correlation result of the test below.

Experiment parameter---experiment material: the fresh animal rich water tissue (muscle) that exsomatizes, microwave frequency: 2,450MHz, maximum microwave power: 300W, room temperature: 16.4 ℃.Temperature test point (being distance in the bracket): A point (0mm), B point (7mm), C point (14mm), D point (21mm), E point (28mm) and F point (35mm) with the top layer.Wherein A point and F point are the surface points of material

During the experimental result---different microwave action times (10,20,30 and 40s), the temperature of each measuring point (℃) as follows

Test point A B C D E F

Initial temperature 16.6 17.1 17.2 17.2 17.1 16.5

The effect 10s after 17.5 17.2 17.2 17.2 17.1 16.5

The effect 20s after 20.8 18.5 17.3 17.2 17.1 16.4

The effect 30s after 26.3 21.6 18.7 17.5 17.3 16.6

The effect 40s after 35.7 22.8 19.6 18.2 17.5 16.6

In above-mentioned experiment, behind each microwave action, all need cool off 1-2 minute, make tissue temperature get back to former initial temperature value substantially.From experimental result, the microwave action time is short more, and the degree of depth that heat effect reaches is just shallow more.Such as under above-mentioned experiment condition, have only to reach action time more than the 30s, just begin to have tangible temperature to raise from the depths of top layer 14mm.The aspect even heat 40s, does not have tangible temperature change from the depths of top layer 28mm yet in addition.So proper as long as parameter and electromagnetic wave model of action are selected, just can realize the accurate control of deep tissues variations in temperature by only changing action time.

The 4th core technology disclosed by the invention is the quantification treatment technology of the dynamic changing process of thermography demonstration.Because the present invention has adopted special physical means that body is heated, so in heating process and in the certain hour of heating after finishing, thermography (or measuring point temperature) all demonstrates tangible dynamic change characterization, and these features are static substantially or only have the character of faint fluctuation to differ widely with common human body thermography (or measuring point temperature).Grasp these features and adopt suitable technological means to carry out analyzing and processing, will help to find faster and more accurately the abnormal structure or the position of body depths.With in the experiment of time controlled microwave depth of interaction, can detect the unusual feature of part that microwave action stops each measuring point variations in temperature of back above-mentioned.Experimental result shows below:

Experiment parameter---experiment material: the animal rich water tissue (muscle) that exsomatizes, microwave frequency: 2,450MHz, maximum microwave power: 300W, room temperature: 16.4 ℃.Temperature test point (being distance in the bracket) with the top layer

A point (0mm), B point (7mm), C point (14mm), D point (21mm), E point (28mm) and F point (35mm).Wherein A point and F point are the surface points of material.

Behind the experimental result---microwave action (20,30 and 40s), at room temperature the temperature of each measuring point (℃) change as follows

Test point A B C D E F

Initial temperature 16.6 17.1 17.2 17.2 17.1 16.5

1. microwave action 20s

The cooling 0s after 20.8 18.5 17.3 17.2 17.1 16.4

The cooling 10s after 18.5 18.4 17.4 17.2 17.0 16.5

The cooling 30s after 17.8 18.3 17.3 17.1 17.1 16.6

The cooling 60s after 16.9 17.7 17.2 17.2 17.1 16.4

The cooling 120s after 16.4 17.5 17.3 17.1 17.1 16.3

2。Microwave action 30s

The cooling 0s after 26.3 21.6 18.7 17.5 17.3 16.6

The cooling 10s after 22.1 20.2 18.8 17.4 17.2 16.5

The cooling 30s after 20.5 19.5 18.4 17.6 17.3 16.5

The cooling 60s after 18.0 18.8 17.9 17.5 17.1 16.6

The cooling 120s after 16.5 17.6 17.7 17.5 17.3 16.4

3. microwave action 40s

The cooling 0s after 35.7 22.8 19.6 18.2 17.5 16.6

The cooling 10s after 26.7 21.9 19.0 18.3 17.5 16.5

The cooling 20s after 23.1 21.5 18.6 18.1 17.4 16.6

The cooling 30s after 20.7 20.9 18.6 18.0 17.4 16.6

The cooling 120s after 17.0 19.8 18.5 17.7 17.1 16.5

From above-mentioned experimental result as can be seen, along with the prolongation of cool time, the temperature of deep tissues does not have any variation substantially.Because bigger with the difference of room temperature, textura epidermoidea can drop to the level near room temperature rapidly, and that the sublevel tissue temperature under the top layer descends is slower, thereby forms the feature that sublevel temperature within a certain period of time is higher than skin temperature on the contrary.Along with the continuation of cool time prolongs, the heat of inferior layer tissue will pass to the top layer gradually, make skin temperature be unlikely to reduce to very soon room temperature, but in a period of time a little higher than all the time room temperature.Be reflected on the Infrared Thermogram, will see a kind of special dynamically temperature-fall period: after microwave heating stops, on the whole active area, initial stage temperature can descend significantly, after blink, fall off rate lowers rapidly, and surface temperature can not reduced to room temperature in a long time fully.The microwave action time is long more, and the time that this temperature-fall period is slowly kept is just long more.If in the dynamic cooling thermography on the large area region of microwave action, find that a certain pocket compares with the peripheral region, temperature is high slightly and cooling is slower, and carry out in time, this region area enlarges gradually, reduces gradually with the temperature difference of peripheral region, and this just points out us, there is an abnormal structure (or zone) in a certain level place under this regional center.This is because it is amplified due to the of short duration deep layer thermal source of back formation one by microwave with the temperature difference of surrounding tissue (or zone).On thermography, the initial time area in this temperature anomaly zone is big more, and the volume of true abnormal structure (or zone) is just bigger.Under the same action condition, the temperature anomaly zone is big more in the temperature difference of initial time and peripheral region on the thermography, and the degree of depth of real abnormal structure (or zone) just may be shallow more.On the basis of a large amount of experiments,, just can find the abnormal structure or the zone of body depths faster and more accurately by dynamic thermographic quantification treatment.This quantification treatment should be passed through making software, allows computer carry out automatically, and its main contents have

1. employing image processing techniques in temperature-fall period, by to thermographic quick auspicious scanning of electromagnetic wave (or ultrasound wave) active region and line scanning, obtains the dynamic data of each point variations in temperature in the zone.

2. these data are analyzed, found out the temperature anomaly zone.

3. locking temperature abnormal area and pocket on every side carry out more accurate scanning, obtain dynamic data more accurately.

4. these data are analyzed, find out the variations in temperature feature (with the dynamic temperature gradient of peripheral region, rate temperature change, the maximum temperature difference at central point and edge etc.) and region shape variation characteristic (the dynamic area in temperature anomaly zone, rate of expansion, center position variation etc.).

5. according to the experimental data and the curve of calculator memory, judge the initial volume and the degree of depth of abnormal structure.

The present invention is suitable for high-risk group's early stage canceration generaI investigation and some other are difficult to the lesion detection of early discovery with X ray.It only needs the easy disease sites of human body is carried out once profound electromagnetic wave (as microwave) or hyperacoustic heating, with thermography observation cooling procedure subsequently, just can roughly determine whether to reach unusually the possible size of abnormal structure and the degree of depth then.In case obtain this information, promptly available same equipment adopts aforesaid chromatographic technique further to detect, and obtains the size and the degree of depth of cancerous issue more accurately.Can arrive hospital then by CT, means such as biopsy or biochemistry obtain the ultimatum.Thereby improve the generaI investigation recall rate with this, alleviate patient and bear the risk of unnecessary X-radiation and reduce diagnostic fees usefulness.

(4), description of drawings

Fig. 1 is the structural representation of the embodiment of the invention.

Fig. 2 is the circuit theory diagrams of microwave generator.

Among the figure: the 1-shell, the 2-central die, the 3-temperature element, the 4-microwave generator, 7-preset temperature unit, 8-microwave power regulon, 9-time regulon, the 10-display screen, 11-display screen control unit, the 12-display lamp, the 13-on and off switch, the 14-safety box, the 15-cooling fan, the 16-outlet, 17-detects the hole, 18-infrared thermal imagery temperature probe, the 19-microwave plumbing, the 20-dielectric film, the 21-block, 22-quasiconductor preheating-pre-cooling pipe, the 23-reticulated cell, the 24-computer interface, 25-cabinet feet, 26-control sequence and transmission fill order unit, 27-date processing and memory element, 28-A-D conversion and amplifying circuit, 29-dc source circuit, 30-data show control circuit, 31-cooling fan control circuit, 32-preset temperature regulating circuit, the 33-time adjustment circuit, the 34-power conditioning circuitry;

4-microwave generator, 41-magnetron, 42-large bulk capacitance, 43-high voltage package, 44-resistance, 45-electric capacity, 46-diode, 47-add alternating current power supply, 48-transformer iron core, 49-ground connection symbol, 50-on and off switch, 51-coil.

(5), the specific embodiment

Embodiments of the invention are referring to Fig. 1, and the medical detecting analyzer of this detection of dynamic body parameter has outlet 16, on and off switch 13, detects hole 17, display screen 10, display lamp 12 and computer interface 24 on the shell 1, comprise following major part in the shell:

Microwave heating element 4:, be used to provide the thermal source of detected skin of heating and deep tissues by the microwave generator that comprises that magnetron 41, high voltage package 43 and large bulk capacitance 42 are formed.The embodiment of microwave heating element 4 is referring to Fig. 2,41 is magnetrons among the figure, the 42nd, and high capacity capacitor, the 43rd, high voltage package (can produce highly compressed transformator), the 44th, resistance, the 45th, electric capacity, the 46th, diode, the 47th, add alternating current power supply, the 48th, the transformer iron core, the 49th, ground connection symbol, the 50th, on and off switch, the 51st, coil.Wherein critical component is a magnetron, the vacuum diode of being made up of cylindrical cathode and coaxial anode.Can require professional production producer by the parameter processing that oneself needs.As existing suitable magnetron is arranged on the market, also can directly buy.Product (model: 2M210-M1 series) as PANASONIC.High voltage package also is like this, can ask specialized factory special on request.Capacitor can directly be pressed parameter request and buy.Above-mentioned microwave heating element can be that the aerial electromagnetic wave that receives is converted by the microwave generator that comprises that antenna, microwave receiving and control circuit are formed also, is used to heat the microwave heating element of detected skin and deep tissues.Above-mentioned microwave heating element can be selected microwave generator, the temperature sensor that contacts with body surface, infrared radiation thermometer, non-contacting thermal infrared imager or non-contacting microwave thermal imaging system.Above-mentioned infrared radiation thermometer is the irradiator of a launched microwave, or gets final product launched microwave, can accept the difunctional irradiator of microwave again.

Microwave plumbing 19: perpendicular to shell, microwave plumbing is inner to be connected with the microwave heating element, it is outside that the outer end mouth of pipe sees through shell, the microwave plumbing outer wall is with quasiconductor preheating-pre-cooling pipe 22, the microwave waveguide inside pipe wall is covered with dielectric film 20, and be provided with the block 21 that the prompting finger stretches into the appropriate degree of depth in detection hole, and form the detection hole 17 that allows finger to insert, be used to guide microwave to directly act on skin and deep tissues; Above-mentioned microwave plumbing can be rectangular tube, round tube or shape of a saddle pipe, and thickness of pipe wall is the arbitrary value of 0.1-10 millimeter, and the contact surface of microwave plumbing and skin is in the pipe or the pipe end edge.

Temperature element 3: be used for monitoring temperature and transmit the variations in temperature eigenvalue to central die, external infrared thermal imagery temperature probe 18 is located at the microwave plumbing inner end, protrudes in inside pipe wall slightly.

Reticulated cell 23 on cooling fan 15 and the shell: be used for cooling, in order to avoid influence testing result next time.

Central die 2: be used for storage and can compile control sequence, send fill order and detect data contrast, calculating and processing automatically, comprising the control sequence that connects quasiconductor preheating-pre-cooling pipe 22 and send fill order unit 26, date processing and memory element 27, A-D conversion and amplifying circuit 28, dc source circuit 29, data show control circuit 30, cooling fan control circuit 31, preset temperature regulating circuit 32 is connected with preset temperature unit 7, is used for being provided with and increase and decrease adjusting preset temperature; Time adjustment circuit 33 is connected with time regulon 9, is used to adjust the length of microwave heating time; Power conditioning circuitry 34 is connected with microwave power regulon 8, is used to regulate the microwave intensity of input.

The effect of quasiconductor preheating-pre-cooling pipe 22 be when tested body initial temperature and preset temperature not simultaneously, by suitable heating or cooling, make finger temperature reach preset temperature.Because the very thin dielectric film of alternating floor microwave plumbing and one deck mutually only between body and the quasiconductor preheating-pre-cooling pipe, so organism temperature is adjusted to desired value easy within a short period of time.

The display screen control unit 11 that is connected with display screen 10: be connected with the output port of data show control circuit 30 in the central die, be used to show detected value and detection time.

Detector of the present invention can be desk-top, portable or hand-held, its central die can be connected with the data storage elements of clock and/or mobile phone, after detection is finished, be stored in the central die in the past the testing result in one period, can send to hospital or give the household for reference by mobile phone.

The method of this detection of dynamic body parameter, the steps include: to set up in advance with the organism parameter value of conventional method detection and the corresponding relation formula of organism temperature changing value, temperature element and microwave heating element are put on body detection position respectively, detection of dynamic or monitor the variations in temperature of this body area then, obtain the temperature information of position to be checked microwave band or infrared band, the temperature at position and the temperature difference between the adjacent normal region are surveyed in the machines health check-up, detected value and corresponding relation formula are compared, draw the organism parameter value.

The wavelength of above-mentioned microwave heating element launching electromagnetic wave from 100m to 0.76 μ m, the especially scope from 1m to 1mm; Frequency of ultrasonic from 20kHz to 20MHz, the scope from 100kHz to 10MHz especially.

Above-mentioned electromagnetic wave or hyperacoustic power are shorter than 60 minutes action time less than 300W.

Above-mentioned microwave heating element acts on position to be detected, tissue or organ earlier, when reaching between ideal temperature or tissue during the temperature difference, begins temperature detection or monitoring with temperature element immediately.Obtain the multidate information of body tissue if desired, above-mentioned two step processes can be carried out repeatedly, under the particular case, are not subjected to Electromagnetic Interference as temperature sensor, and the then above-mentioned process that was divided into for two steps can be carried out simultaneously.

Fig. 1 shows is a kind of system that can noinvasive detects blood glucose that designs according to the proposed method, and its core component has three: i.e. microwave generator, infrared thermal imagery pick off and central die.1 is shell among the figure, the 2nd, and central die, the major function of central die are that storage can be compiled control sequence, the transmission fill order reaches and detects the data contrast automatically, calculates and handle, comprising control sequence and transmission fill order unit 26; Date processing and memory element 27; A-D conversion and amplifying circuit 28; Dc source circuit 29; Data show control circuit 30; Cooling fan control circuit 31; Its preset temperature regulating circuit 32 is connected with preset temperature unit 7, is used for being provided with and increase and decrease adjusting preset temperature; Its time regulating circuit 33 is connected with time regulon 9, is used to adjust the length of microwave heating time; Its power conditioning circuitry 34 is connected with microwave power regulon 8, is used to regulate the microwave intensity of input.3 is temperature elements of being responsible for monitoring temperature and transmission temperature data among the figure, and it links to each other with A-D conversion and amplifying circuit, and the latter links to each other with date processing and memory element.The data show control circuit links to each other with date processing and memory element, and the 11st, the display screen control unit, it links to each other with the data show control circuit.Dc source circuit 29 in the central die is mainly used in provides required running voltage in each unit and electric current.Microwave generator 4 is by magnetron 41, and high voltage package (high-tension transformer) 43 and large bulk capacitance 42 are formed, and are responsible for producing selected power and the microwave of time.The 10th, LCDs is used to show and detects the blood sugar concentration that obtains, detection time and in the past detected content such as data.The 12nd, display lamp, when microwave generator starts, this lamp will glimmer, and point out formal detection to begin. and after detection was finished, this lamp extinguished automatically.The 13rd, on and off switch, the 14th, safety box when impressed current transships, can melt disconnected with the protection entire equipment automatically.The 15th, with the cooling fan that cooling fan control circuit 31 links to each other, its effect is to the microwave generator cooling, in order to avoid higher device temperature influences testing result before detecting next time after one-time detection is finished.Wind inlet of fan is located at the cabinet sidewall, and fan airstream is over against microwave generator, and air stream outlet is located at the sidewall on air inlet opposite.The 16th, be fixed on the outlet of the connection external power on the cabinet.The 17th, detect the hole, its internal diameter size should make people's finger just insert, and is not too tightly also not too loose. can establish multiple model, to be suitable for from the child to adult's use that thick especially finger is arranged.Detecting hole depth can select in the 5-50 millimeter.18 are arranged on the infrared thermal imagery temperature probe that detects on the hole.Probe orientation needn't be perpendicular to internal surface of hole, and probe keeps certain distance with finger, and the temperature data that probe obtains is converted to directly to pass in the temperature element 3 behind the signal of telecommunication and handles.The 19th, metal pipe, tube section are preferably the garden type, and bore should be a bit larger tham the detection hole, and thickness of pipe wall can be selected in the 0.1-10 millimeter.The effect of pipe is similar to waveguide, can guide microwave emission (conduction) direction, and the microwave that magnetron 4 is sent mainly acts on material or the medium (promptly pointing the tissue of front end) that detects in the hole.The 20th, dielectric film, its effect is that finger and waveguide metal are isolated in insulation, to prevent under the microwave action discharge between the two, the sensation (though very slight) that causes the patient to have to be shocked by electricity, dielectric film must be made with the material that does not absorb microwave (as rubber, plastics), in order to avoid scald finger during microwave heating, influence the temperature detection accuracy simultaneously.The 21st, the finger plate washer, its effect is that prompting instrument user finger stretches into the appropriate degree of depth that detects the hole.The 22nd, quasiconductor preheating-pre-cooling pipe, its effect are when pointing initial temperature and preset temperature not simultaneously, by suitable heating or cooling, making finger temperature reach preset temperature.The waveguide and the very thin dielectric film of one deck of layer of metal owing to only be separated by between finger and the quasiconductor preheating pre-cooling pipe are so finger temperature is adjusted to desired value easy within a short period of time.The 23rd, as the reticulated cell of cooling fan air stream outlet, its Position Design makes microwave generator on the cabinet wall, quasiconductor preheating-pre-cooling pipe and detect temperature in the hole and can both descend as early as possible and reach room temperature.The 24th, computer interface can be realized data or communication for information between detector and the external computer by it.The 25th, the cabinet feet.

The operation principle and the process prescription of this detector are as follows: detect hole 17 when detected finger stretches into, after finger tip touches finger plate washer 21, start power on switch 13, central die 2 is sent instruction, allow temperature element 3 begin to detect the initial temperature of finger end skin each point by infrared thermal imagery temperature probe 18, after testing result passes to 2 by 3, calculate mean temperature and compare with the preset temperature that is stored in 2, if any difference, central die 2 will be sent instruction, start quasiconductor preheating-pre-cooling pipe 22, under the monitoring of infrared thermal imagery temperature probe 18, the time length of decision preheating or pre-cooling, and the temperature equalization problem of consideration subcutaneous depth tissue are till the temperature of confirming whole finger tip reaches preset temperature fully.Central die 2 will be sent the instruction of formal detection this moment, allow microwave generator 4 by predefined power, frequency and action time begin to send microwave, detect display lamp 12 simultaneously and begin flicker.Microwave is drawn towards finger by microwave plumbing 19, and temperature element 3 beginning (or waiting microwave action to stop the back) is pointed the each point variation of temperature by 18 monitorings of infrared thermal imagery temperature probe, and transfer of data is stored to central die 2.After microwave heating stops, detecting display lamp 12 and extinguish.But the still possible certain time of temperature monitoring is to obtain more data.Central die 2 will be carried out analyzing and processing to the data of all storages, make comparisons and will calculate by preset program and memory information, finally obtain pointing capillary tube whole blood blood glucose concentration value, and show by LCDs 10.After detection was finished, finger withdrawed from and detects hole 17, and central die 2 will provide instruction, start cooling fan 15, blow air cooling instrument, and the numerical value that infrared thermal imagery temperature probe 18 measures in detecting the hole is with till room temperature equates.After cooling fan stops, turning off on and off switch.Wait for next time and detecting.The detector user can pass through interface 24, accesses the plurality of detection result who is stored in the central die in the past in one period, and unloading is in computer or to deliver to hospital for reference.

Detecting instrument of the present invention can find a lot of application on medical science detects, be the part example below.

Application example one " mode that changes a certain position of body or organ temperature by microwave is carried out the detection of non-invasive blood glucose value "

The present invention proposes the method that a kind of noinvasive detects, can overcome the shortcoming that has wound to detect substantially.

As everyone knows, the glucose normal contents in the body fluid is (on an empty stomach) 3.9-6.1mmol/L (or 70-110mg/dL).7.0-8.4mmol/L for slightly increasing, 8.4-10.1mmol/L is that moderate increases, as＞10.1mmol/L is that severe increases.As fasting blood glucose level 〉=7.0mmol/L and at random after level 〉=11.1mmol/L or the anti-sugar experiment after 2 hours 〉=11.1mmol/L is the diabetes positive.Blood sugar level is regulated by insulin and glucagon, and the former reduces blood glucose, and the latter makes its rising.So under the normal condition, the blood sugar for human body level can be controlled in certain limit.1-2 hour after meal, high-carbonhydrate diet or when excited blood glucose all temporary transient increase may appear, all belong to the normal physiological rising.

Because glucose molecule is little, has dipole moment, concentration is higher relatively, so externally add the reaction sensitivity of electromagnetic field.Contribute bigger to the calorigenic effect that is organized under the electromagnetic field effect.Thereby when other condition (adding the electromagnetic field field, site of action, conduction of heat condition, health etc.) was constant substantially, the variations in temperature feature that heating causes was just mainly relevant with heating blood sugar concentration constantly.A large amount of experiments of inventor have confirmed this conclusion.

Provide below and adopt instrument of the present invention and above-mentioned detector model machine to carry out the partial results that blood sugar test obtains.Test parameter is as follows: wave frequency 2,450MHz, peak power 150W, maximum power density: 850mW/cm ², the longest action time 5Min.Temperature measurement accuracy+/-0.1 ℃, 23 ℃ of preset temperatures.Waveguide overall diameter 15mm detects hole internal diameter 12mm.Total moisture content pops one's head in several 3.

Demarcate contrast and adopt the common invasive blood-sugar detecting instrument that has, its model is the full TM vigor of Luo Kang type (ACCU-CHECK) blood-sugar detecting instrument.Need blood volume 1-2 microlitre, detecting reagent paper is the glucose oxidase enzyme test peper.200 of memory data outputs.The blood glucose unit of display: mmol/L represents with G in the experimental data below

Detected object: A, (blood glucose normal male, 47 years old);

B, (type ii diabetes patient, man, 55 years old);

C, (the carbohydrate tolerance person of going down, man, 52 years old)

Detection mode one: ante cibum is a period of time on an empty stomach and after meal, detects experimenter's blood glucose simultaneously with two kinds of methods (be instrument of the present invention and as the correlated method of cracking of demarcation).

Detection mode two: undertaken by glucose tolerance test (OGTT) rule fully.Promptly, should avoid using glycometabolic ethanol of influence and medicine, fasting at least 10 hours (but can drink water) before the test therebetween not carrying out in dietary restriction and the early morning (morning) after normal physical exertion 2-3 days before.Carry out earlier the blood sugar test of following two kinds of methods (being that correlated method of cracking is demarcated in the inventive method and conduct) on an empty stomach simultaneously.Allow the experimenter drink to contain the aqueous solution 250-300 milliliter of 75 gram glucose powders (or 82.5 gram monosaccharide) again, in 5 minutes, drink.Clothes 1 hour and 2 hours after the sugar is detected experimenter's blood glucose simultaneously with two kinds of methods.

Temperature profile parameter (being the meansigma methods of 3 probes)

(1), microwave heating stops back 1 minute temperature T _60S(℃)

(2), microwave heating stops back 2 minutes temperature T _120S(℃)

(3), microwave heating stop in back 2 minutes maximum temperature Tmax (℃)

(4), microwave heating stop in back 2 minutes temperature increase speed K (℃/s)=(Tmax-T ₀)/(tmax-t ₀) wherein:

T ₀, tmax and t ₀Representative detects the temperature in the initial moment respectively, and maximum temperature goes out now and detects the initial moment.

Testing result is enumerated in following:

Detection mode one experimenter A

1 as a child 2 hours after meal 4 hours after meal after meal 0.5 hour ante cibum of 2 hour ante cibum

G(mmol/L) 5.6 5.2 7.0 6.5 5.7

T _60S(℃) 25.5 25.0 29.6 25.8 25.3

T _120S(℃) 24.8 24.7 29.2 24.7 24.6

Tmax(℃) 25.8 25.6 29.7 25.8 25.8

K(℃/s) 0.042 0.038 0.107 0.042 0.042

Experimenter B:

1 as a child 2 hours after meal 4 hours after meal after meal 0.5 hour ante cibum of 2 hour ante cibum

G(mmol/L) 8.3 8.1 12.5 11.9 11.8

T _60S(℃) 31.4 31.5 41.4 40.6 40.8

T _120S(℃) 29.2 28.8 33.3 33.0 32.7

Tmax(℃) 31.6 31.6 41.4 40.8 40.8

K(℃/s) 0.138 0.138 0.302 0.292 0.292

Detection mode two: experimenter A

Back 0.5 hour clothes sugar of the preceding clothes sugar of (medicine) being taken before meal sugar was obeyed sugar back 2 hours in back 1 hour

G(mmol/L) 5.1 7.3 8.2 7.4

T _60S(℃) 25.2 29.7 32.0 29.6

T _120S(℃) 24.5 29.2 30.1 29.0

Tmax(℃) 25.5 29.8 32.0 29.8

K(℃/s) 0.037 0.108 0.145 0.108

Experimenter C

Back 0.5 hour clothes sugar of the preceding clothes sugar of (medicine) being taken before meal sugar was obeyed sugar back 2 hours in back 1 hour

G(mmol/L) 7.5 8.3 10.2 11.0

T _60S(℃) 30.0 32.7 38.6 39.0

T _120S(℃) 29.2 32.0 34.5 34.9

Tmax(℃) 30.0 32.9 38.6 39.2

K(℃/s) 0.112 0.160 0.255 0.265

From above-mentioned testing result as can be seen, the blood glucose value that obtains with resulting temperature profile data of instrument of the present invention and conventional glucose oxidase method has on all four increase and decrease trend over time.Reaction is responsive, is enough to as new blood glucose characterization value.But not linear relationship between the two, unlikely go out with a simple mathematical analytic expression table.And should describe with a nonlinear empirical equation or curve.This need do more experiment, and by just drawing behind the statistical analysis.The detector that Fig. 1 shows is to adopt the infrared thermal imagery temperature probe to detect the temperature of the indivedual points of finger tip.Also can adopt small-sized thermal imaging system to monitor the temperature variations of whole finger end, improve the accuracy and the precision of detection with this.

The application example two of instrument of the present invention " by the mode of the microwave amplification different tissues or the interregional temperature difference, helps detecting the canceration information of body depths ".

Instrument of the present invention has been opened up a kind of brand-new organism parameter and has been surveyed thinking, and the rationale that the present invention can be applied in this regard is its grade malignancy of structure special-shaped property decision of (1), tumor tissues.Heteromorphism is high more, and the cancerous tissue differentiation degree is low more, and the matter blood vessel is abundant more and connective tissue is few more therebetween, and it is rapid more to grow, and prognosis is poor more.So the blood vessel hyperplasia of pernicious cancerous tissue is many more, moisture content is just high more, and as previously mentioned, under the effect of suitable electromagnetic wave (as microwave), its heat effect is just remarkable more.(2), the pathological change metabolism always of body changes formerly, morphosis change after.The metabolic activity Showed Very Brisk of malignant tumor tissue can need more glucose than normal structure, and therefore, its concentration of glucose also just is higher than its hetero-organization.Given this, tumorigenic early stage, when a lot of morphology image checks were not found the body abnormal change, the glucose metabolism video picture just can " have been reported to the police ".At present, an emerging glucose metabolism imaging technique promptly is that radionuclide is synthesized to glucose, become and have radioactive glucose, after injecting it in the human body, with detection instrument in external reception emission signal, and carry out Flame Image Process, just can obtain the radioactivity glucose at the intravital scattergram of people.It can reflect the situation of partes corporis humani's glucose metabolism.Can be used for diagnosing the tumor of a lot of types.But because inspection fee is higher, can not be as the primary dcreening operation inspection of diagnosing tumor.Generally suspect and conventional imaging examination does not find that under the situation such as focus, it is just comparatively suitable to use at clinical height.From aforementioned first example as can be seen, the relation of being proportionate of the heat effect under concentration of glucose and the microwave action.So needn't use radionuclide, the method that adopts the present invention to propose just can reach similar effects.(3), a large amount of medical experiments shows, when using the electromagnetic wave therapy cancerous issue, can make cancerous cell the high 5-10 of temperature ℃ than normal surrounding tissue, while is owing to structure is unusual, these heat can not spread out of again rapidly, cause the accumulation of heat in the cancerous issue, and temperature can reach more than 40 ℃.

In sum, cancerous issue can be amplified with the small temperature difference in surrounding tissue or zone, significantly at temporary transient thermal source of body depths formation in suitable electromagnetic wave (as frequency and the power density microwave in certain limit) effect down.Adopt aforementioned chromatographic technique and/or thermography quantification treatment technology that the regional temperature variation that this thermal source causes is detected, just may obtain the information that this depths, zone has early stage cancerous issue.Following experiment preliminary identification the feasibility of this method.

Experiment material----artificially forms one with syringe in 25mm depths, distance top layer and is rich in blood district (about 2 * 2 * 2mm of volume in the fresh rich water tissue of stripped animal (muscle) ³, with the simulation cancerous region.The a little higher than human body normal value of concentration of glucose (being 12mmol/L) in the blood.

Experiment parameter----microwave frequency: 2,450MHz, microwave power: 300W, room temperature: 16.5 ℃.Temperature test point (being distance in the bracket): A point (0mm), B point (7mm), C point (18mm), E point (32mm), F point (40mm) and simulation cancerous issue point M (25mm) with the top layer.Wherein A point and F point are the surface points of material.

Behind experimental result----the microwave action 50s, at room temperature the temperature of each measuring point (℃) change as follows

Test point A B C M E F

Initial temperature 16.6 17.1 17.2 17.2 17.1 16.5

The cooling 0s after 40.5 28.9 22.2 23.5 17.9 16.7

The cooling 10s after 30.7 26.9 21.7 23.0 17.8 16.4

The cooling 20s after 25.3 25.4 20.9 22.1 17.5 16.6

The cooling 30s after 21.6 24.8 20.7 21.5 17.4 16.5

The cooling 120s after 17.8 23.7 20.3 21.2 17.6 16.4

The cooling 180s after 17.1 20.9 20.0 20.1 17.3 16.5

From then on experimental result temperature anomaly occurred at simulation cancerous issue point M place as can be seen, behind the microwave action, this point tissue and more the temperature difference of shallow layer tissue (7mm apart) can reach 1.3 ℃, can reach 5.8 ℃ with the temperature difference of deep tissues (7mm apart) more.Until cool off after 3 minutes, this temperature difference is still fairly obvious, and this just is to adopt variations in temperature feature infrared or that microwave thermal image pattern quantification treatment technical Analysis body reflects, thereby may obtain the information of the early stage cancerous issue in depths.The inventor adopts U.S. hand-held FLIR1 infrared thermal imagery photographic apparatus, the material surface behind the microwave heating is observed continuously, really see in the cooling procedure, there is the high slightly zone of a temperature with respect to the top layer directly over the M point, diameter is enlarged gradually by the 10-15mm in when beginning, reduce gradually simultaneously, change just complete obiteration of zone after about 11 minutes with on every side the temperature difference.If adopt more accurate thermal imaging system, should obtain administrative division map more clearly, and can detect the accurate degree of depth that M is ordered by adopting chromatographic technique.

The information that application example three " helps detecting the diagnosing ischemia induced osteonecrosis by investigating the heat conducting mode of osseous tissue ".

Ischemic osteonecrosis claims ANB or aseptic osteonecrosis again, is to cause one of the hip arthralgia and handicapped common cause.In addition, the moon osteonecrosis of palm is also more common, is called the Kienbock disease again.Be common in the labourer who exerts oneself with wrist among the person between twenty and fifty, as the laundry man, weaving worker or pneumatic pick hands.Be because long-term chronic damage has caused the disturbance of blood circulation of lunar, produce ischemic necrosis at last.Its clinical onset is slow, and wrist pain and unable is only arranged in early days, has a rest slightly and can alleviate, and difficulty arouses attention.It is invalid that X ray detects in early days the stage, only in the morbidity several months, just shows some variations with profile of increasing of month bone density after the existing obvious necrosis.Other detection meanss (as CT and ultrasound wave), also powerless in early days in morbidity.Instrument of the present invention can detect early stage osteonecrosis, is example with palm lunar, the steps include:

1. select the ultrasound wave of suitable parameters (as frequency 1-3.2MHz, radiant intensity 0.1-0.2W/cm ²) and the sound head of diameter 0.5-1.0cm, aim at moon bony site of morbidity hands one side (as palm of the hand face) and launch ultrasound wave.Be no more than 5 minutes action time.Couplant is selected acoustic resistance and the approaching material (as water, the emulsion that Oleum Ricini becomes with emulsifier) of human body soft tissue.

2. a period of time ultrasonic emitting the time or after a while is in the opposite side (as the back of the hand face) of the palm variations in temperature with thermal imaging system monitoring lunar zone.

3. the behavioral characteristics (as rate temperature change, lunar central point variations in temperature and change in location etc.) that adopts aforementioned hot image pattern quantification treatment technical Analysis lunar regional temperature to change.

4. set up normal lunar zone heat conduction model, set up normal variations in temperature data base by experiment.

5. the dynamic change characterization of patient's lunar regional temperature and the normal data of calculator memory are compared, determine lunar hematologic effects degree, provide corresponding data for doctor's reference.

Theoretical foundation is as follows: (1), ultransonic heat effect mainly are the results that tissue absorbs acoustic energy.Different tissue differs bigger to the absorption characteristic of acoustic energy in the human body.Generally speaking, fine and close more tissue, ultransonic heat effect is strong more.Especially the most remarkable with osseous tissue, secondly be connective tissue, fat and blood are the most weak.(2), because the acoustic resistance of muscle and skeleton differs bigger, ultrasound wave reflect on periosteum-bone interface and decays seriously, is difficult to penetrate skeleton, but forms partial high-temperature region near interface.Experiment shows, uses 1MHz, 1W/cm ²Ultrasonic, can in the scope of interface 1cm, produce projecting 5-7 ℃ humidity province.(3), the unusual high temperature of this bone surface will cause the hot-fluid propagated in bone, finally can pass to the surface by lunar and muscle, make on the thermography of palm corresponding temperature anomaly zone to occur.(4), the blood circulation in the lunar helps the conduction of above-mentioned hot-fluid, but to downright bad, avascular sclerotin, heat conducting speed will be starkly lower than normal structure.So the ratio of slough just can obtain by the quantification to respective regions variations in temperature on the thermography in the bone.

As previously mentioned, people's asthenia water tissue (especially skeleton) is very weak to the absorption of microwave, and microwave can be easy to penetrate skeleton and less generation heat effect, though can be absorbed in muscle, the accumulation of heat is arranged in the interface of bone and muscle difficulty.So in the detection that relates to skeletal diseases, adopt ultrasound wave rather than microwave to heat more.Following experiment has confirmed the feasibility of this detection to a certain extent.

Experiment parameter---experiment material: fresh animal is exsomatized and contains the rich water tissue (muscle) of bone, supersonic frequency: 1MHz, peak power: 250W, radiant intensity 0.5W/cm ², room temperature: 16.8 ℃.Temperature test point (being distance in the bracket) A point (0mm) with the top layer, B point (10mm), C point (28mm), D point (55mm), the distance on bone and top layer is 30-43mm in the material.Wherein A point and D point are the surface points of material.

Experimental result--behind-ultrasound wave effect the 240s, at room temperature the temperature of each measuring point (℃) change as follows

Test point A B C D

Initial temperature 17.1 16.1 15.8 17.2

The cooling 0s after 17.3 16.5 20.3 17.4

The cooling 10s after 17.2 17.0 19.6 17.7

The cooling 30s after 17.4 17.3 19.0 17.3

The cooling 60s after 16.8 17.1 18.4 16.7

The cooling 120s after 16.4 17.2 18.0 16.6

From experimental result, C point temperature occurs unusual, and the accumulation of heat can appear in this main schedule where there is light in the zone of bone and muscle near interface.This temporary deep layer thermal source will send hot-fluid gradually towards periphery; cause the rising of peripheral region temperature; even reflect also that at material surface slight temperature raises, so adopt accurate thermographic technique just may obtain the information of skeleton under the soft tissue from these clues and traces.

Instrument of the present invention also can obtain other similar application, the moon that occurs in the X ray plain film such as lung cancer in medical science detects Shadow easily and pulmonary tuberculoma obscure, cause mistaken diagnosis. As adopt instrument of the present invention to detect, then do not have this situation and take place. This is Because when adopting electromagnetic wave (microwave) to do the time spent, cancerous lung tissue has obvious temperature to raise, the tuberculoma of calcification then can not. When adopting ul-trasonic irradiation, just in time conversely, the tuberculoma temperature can raise, and cancerous lung tissue is reaction not. In a word, the present invention Advantage be: testing process does not have wound and fast, equipment is simpler, and testing cost is lower, compare with X ray and CT etc., Radiation to human body is much smaller, compares with TTM, is conducive to determine shape and the position of lesion region.

Claims (5)

1. the medical detecting analyzer of a detection of dynamic body parameter is characterized in that: outlet, on and off switch, detection hole, display screen, display lamp and computer interface are arranged on the shell, comprise following major part in the shell:

Microwave heating element: the thermal source that is used to provide detected skin of heating and deep tissues;

Microwave plumbing: perpendicular to shell, microwave plumbing is inner to be connected with the microwave heating element, it is outside that the outer end mouth of pipe sees through shell, the microwave plumbing outer wall is with quasiconductor preheating-pre-cooling pipe, the microwave waveguide inside pipe wall is covered with dielectric film, and be provided with block, and form and detect the hole, be used to guide microwave to directly act on skin and deep tissues;

Temperature element 3: be used for monitoring temperature and transmit the variations in temperature eigenvalue to central die,

Cooling fan: be used for cooling, in order to avoid influence testing result next time;

Central die: be used for storage and can compile control sequence, send fill order and detect data contrast, calculating and processing automatically, comprising the control sequence that connects quasiconductor preheating-pre-cooling pipe and send fill order unit, date processing and memory element, A-D conversion and amplifying circuit, dc source circuit, data show control circuit, cooling fan control circuit, the preset temperature regulating circuit is connected with the preset temperature unit, is used for being provided with and increase and decrease adjusting preset temperature; Time adjustment circuit is connected with the time regulon, is used to adjust the length of microwave heating time; Power conditioning circuitry is connected with the microwave power regulon, is used to regulate the microwave intensity of input;

The display screen control unit that is connected with display screen: be connected with the output port of data show control circuit in the central die, be used to show detected value and detection time.

2. the medical detecting analyzer of detection of dynamic body parameter according to claim 1, it is characterized in that: above-mentioned medical detecting analyzer is desk-top, portable or hand-held, its central die is connected with the data storage elements of clock and/or mobile phone, after detection is finished, be stored in the central die in the past the testing result in one period, can send to hospital or give the household for reference by mobile phone.

3. the medical detecting analyzer of detection of dynamic body parameter according to claim 1 is characterized in that: above-mentioned heating element heater is by the microwave generator that comprises that antenna, microwave receiving and control circuit are formed.

4. the medical detecting analyzer of detection of dynamic body parameter according to claim 1 is characterized in that: above-mentioned temperature element is temperature sensor, infrared radiation thermometer, thermal infrared imager or microwave thermal imaging system.

5. the medical detecting analyzer of detection of dynamic body parameter according to claim 1 is characterized in that: above-mentioned microwave plumbing is rectangular tube, round tube or shape of a saddle pipe.

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