CN100397072C - Mini type electrophoresis detection system of microflow control chip, and method for controlling automatic testing - Google Patents
Mini type electrophoresis detection system of microflow control chip, and method for controlling automatic testing Download PDFInfo
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- CN100397072C CN100397072C CNB2005100279044A CN200510027904A CN100397072C CN 100397072 C CN100397072 C CN 100397072C CN B2005100279044 A CNB2005100279044 A CN B2005100279044A CN 200510027904 A CN200510027904 A CN 200510027904A CN 100397072 C CN100397072 C CN 100397072C
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Abstract
The present invention relates to a miniature electrophoresis detection system of a micro-flow control chip and an automatic control method for detection. The miniature electrophoresis system selects an AMC7820 chip of a TI company as a collection control microprocessor of the system, and the miniature electrophoresis detection system of a micro-flow control chip is designed; the control to a high-voltage power supply and the collection of signals during the chip sampling and separation are realized by the A/D function and the D/A function of the AMC7820 chip; a superior PC realizes the communication with an SPI serial port of the AMC7820C by a 25 needle parallel port, and thus, a complete control system of information collection is formed; the electrophoresis detection system of a micro-flow control chip is utilized to firstly carry out sensitivity regulation to a photomultiplier, setting of sampling separation parameters and automatic detection of the system; thus, the automatic control of the electrophoresis process of a micro-flow control chip and the intellectualized operation of the whole detection system are realized, and a result is analyzed and printed.
Description
Technical field
The present invention relates to a kind of combining with software and micro-fluidic chip check and analysis system is realized the method for automated intelligent control, belong to the micro-system automation control area based on MCU.
Background technology
Micro-full analytical system (miniaturized total analysis system, μ TAS) is that collection sample introduction, sample preparation, biochemical reaction, separation, detection are the miniature detection of global function and the analytic system of one
[1]Micro-fluidic chip (Micro-fluidic chip) is its main building block, it adopts micro-processing technology (MEMS) to produce sample introduction and split tunnel and other functional unit of micron order pipeline as biological sample on substrates such as glass, silicon, polymkeric substance, driving sample in the electric field mode flows in microchannel, by photomultiplier (PMT) or other detecting elements the amplification of the feeble signal that sample produced on the separating pipe is converted into electric signal at last, and carries out collection analysis by PC or single-chip microcomputer and handle.It combines capillary electrophoresis technique (CE) and micro-processing technology (MEMS) the micro-fluidic electrophoresis chip technology, has fast, advantage such as efficient, low consumption, has a wide range of applications in environmental monitoring, medicine screening and clinical diagnosis.
In the micro-fluid control chip electrophoretic signal detection system, can adopt multi-functional industry control integrated circuit board (as middle safe PC-6315) or stand-alone development MCU (microprogram control unit) detection system.The industry control integrated circuit board generally contains mould goes into/mould outgoing interface and multi-path digital I/O, connects with PC by standard I SA slot and communicates by letter, and good compatibility and antijamming capability are arranged.But the developing trend of analytical instrument is in miniaturization, intellectuality, family expensesization, and this type of general industry control integrated circuit board, structure is huge, is provided with and the programming complexity, is unfavorable for the miniaturization of detection system, is not suitable for the application in the portable detector.
Summary of the invention
Based on system's miniaturization and the consideration that reduces cost, the invention provides a kind of electrophoresis detection system of microflow control chip and autocontrol method.
Specifically, the present invention's AMC7820 chip of choosing TI company as the acquisition controlling microprocessor Design of system one mini type electrophoresis detection system of microflow control chip; Described system is made up of automatically switch module and signal acquisition process module of PC, AMC7820 chip, high-voltage power supply control module, pattern, system be A/D and the D/A function by the AMC7820 chip when realizing the chip sample introduction separated high-voltage power supply control and the collection of signal.Upper PC is realized communicating by letter of the two by 25 pin parallel ports with the SPI serial ports of AMC7820C, thereby constitute a complete information acquisition control system, realized the automatic control of micro-fluid control chip electrophoretic process and intellectualized operation and the interpretation of result and the printing of whole detection system.Have and control advantages such as convenient, intelligent, automatic.
1. the hardware setting of system and control principle
Principle such as Fig. 1, it is chip AMC7820 with the TI company MCU core that is as the criterion, by being unified into a complete detection control system with PC.
Its main modular is as follows:
A.PC machine and AMC7820 communication interface modules
PC is realized communicating by letter by 25 pin parallel port lines with AMC7820 between the two.Set up the buffered communication system between the two, it realizes high quality communication between the two with two SN74AHC244PWR buffer chips.
Simultaneously, what carried out the PC parallel port is parallel work-flow, and the communication interface that AMC7820 had is SPI four line serial ports.This has caused certain conflict, and in order to realize normal communication function under the situation that does not increase other chips, system has realized string-and transition of communications with software, obtains good effect.
B. pattern automatic switchover module
In order to realize the accurate automated intelligent control to Instrument working state, system has adopted relay as control its switch.Because AMC7820 only is an analog digital device, does not contain digital I/O mouth, can't be realized the control of relay by it, so system adopts the parallel port of PC to realize the output of digital signal after the SN74AHC244PWR buffering.
Relay adopts the 5V Control of Voltage, belongs to current control device, and the PC parallel port belongs to Transistor-Transistor Logic level, and driving force is poor, can't drive relay work.Based on realizing that this function reaches the protection to circuit and PC, system has adopted opto-coupler chip and Darlington transistor to form the driver module of relay simultaneously, and principle such as Fig. 2, optocoupler are TLP504A, and Darlington transistor is ULN2003A.
By TLP504A, cut off circuit and outside broken height is pressed high flow relation, simultaneously again constant the passing of Transistor-Transistor Logic level, realized protection mechanism.But the level of this moment still be a Transistor-Transistor Logic level, can't drive relay work, so carry out the electric current amplification during employing ULN2003A Darlington transistor, thereby produce the ability that drives relay, and be connected to external interface, and drive I/O thereby produce relay, realize the automatic switchover work of system model by it.
C. high-voltage power supply control module
Native system has adopted the chip capillary cataphoresis type of drive.Because the lewis' acid of each component materials of sample there are differences in electromigration or distribution behavior, system adopts high-voltage DC power supply as driving force, has realized high-speed separation, the detection to the biological specimen component fast and has analyzed drive principle such as Fig. 3.It can finish sample fast in 2～3 minutes compartment analysis detects.
During sample introduction, 1. sample cell 5 and waste liquid pool join at 6 two ends in high-voltage power supply control module mesohigh power supply and the micro-fluidic chip, and voltage is 0～+ 1000V, be initialized as 500V, the time is 30 seconds; During separation, 2. high-voltage power supply and buffer pool 7 and waste liquid pool 8 be connected, and voltage is 0～+ 5000V, be initialized as 2000V, the time is 10 minutes.
In order to realize that sample introduction separates the adjustable control of driving voltage, high-voltage power supply adopts 0～+ the continuous adjustable line traffic control of 5V, system adopts the DAC0 and DAC1 output aanalogvoltage of AMC7820, thereby cooperates the work of relay realization high-pressure modular automatic and adjustable again.
D. information acquisition processing module
Because high-voltage power supply and micro flow control chip capillary complex internal structure, easily make detection signal have the noise of high frequency and thermonoise etc., simultaneously, hardware circuit itself also contains thermonoise and random noise, therefore adopt be the fertile low-pass filtering now of 8 rank Barts after, the A/D by AMC7820 carries out information acquisition again.Filtering circuit such as Fig. 4.
2. system software module design
System has realized the intelligent automatic control of system based on the above-mentioned hardware foundation in conjunction with software.Software adopts VC to write, and operation interface (as Fig. 5) is intuitively arranged, and it has intelligent mistake proofing, advantage such as easy and simple to handle.
Simultaneously, system bottom adopts the DLL chain program to write, and upgrading is convenient.It contains 4 main modular: measurement sensitivity is regulated dialog box, the dialog box module of separating the sample introduction parameter, test process demonstration dialog box module, sample message curvilinear figure display module.
It has following characteristics:
A. the intelligent automatic regulated dialog box of sensitivity
The signal that micro-fluidic detection detected is faint electric signal, in order to reach desirable detection effect, carry out certain control to the sensitivity of photomultiplier (PMT), and it realizes the adjustable control of PMT by AMC7820 output 0～1V DC voltage.
At the sensitivity control characteristic of system's photomultiplier (PMT), program adopts autonomous cycle criterion, has realized that the oneself's control and the oneself that regulate judge, have reached higher robotization and intellectuality.Adjustment process can full-automatic or semi-automatic finishing, and interferes or carry out can finishing the PMT sensitivity adjusting fast under a spot of the setting no operating personnel.Regulate dialog box such as Fig. 6.
Control voltage: PMT sensitivity adjustable voltage, can be adjustable between 0～1000mV, be initialized as 500mV;
Sensitivity is provided with: sensitivity pre-sets, can be adjustable between 0～10, be initialized as 6;
Background signal: the sample background voltage signal shows when sampling in real time.
System regulates PMT automatically and trends towards designed value according to the initial setting up parameter of dialog box, and operating personnel only need control one " adjusting " button can fast automaticly finish this work.
And before carrying out this step operation, other parameter setting and control operation all are forbidden, have so just prevented the possibility that faulty operation takes place.
B. setting of sample introduction separation parameter and control automatically
Before sensitivity did not regulate, the sample introduction separation parameter is prohibited established, and had guaranteed that so whole check and analysis process can carry out accurately, had prevented wrong generation.Fig. 7 is that the sample introduction separation parameter is provided with dialog box.
Sample introduction voltage: 0～+ 1000V; Sample injection time: 0～60 second
Separation voltage: 0～+ 5000V; Disengaging time: 0～10 minute
After the PMT sensitivity adjusting was finished, this dialog box was activated, and shown in Fig. 7 b, thereby can carry out the parameter setting that sample introduction separates.When software startup, these parameters have been initialized to standing parameter, generally need not change again, and directly start detection gets final product.Change parameter as need, also can change with keyboard or mouse easily, have good dirigibility.
After the start detection, whole testing process realizes automatic control and treatment by program.Automatic Program obtains the process parameter from dialog box, thereby realizes high-voltage power module is controlled in the D/A output of AMC7820 chip by the SPI serial ports then, reaches the purpose of automatic control.
The sequence of steps of whole testing process is realized automatically by the SetTimer function startup timer interrupt routine of PC, the interrupt routine self-clocking, and compare with dialog box sample introduction disengaging time parameter, thereby the automatic switchover of control sample introduction, detachment process, and finish The whole analytical process automatically after finally finishing the check and analysis process.
Trace demonstration in real time and trace are adjusted automatically when c. detecting
After AMC7820 collected signal, it in time was uploaded to PC, and carried out realizing being presented on the interface after digital filtering is handled with PC, and as shown in Figure 8, the testing staff can observe testing result in real time, thereby makes the concrete property of differentiating sample in time.
As shown in Figure 8, the concentration that collection of illustrative plates comes certain composition in the representative sample with peak area during detection, the big more representative concentration of area is high more.At the test sample of variable concentrations, the peak area of appearance is also inequality.System software is the difference of concentration per sample, can intelligence automatically adjust spectrum trace displaying ratio, makes it can not exceed to show outside the dialog box, realizes the function handled automatically, and adjustment that need not operating personnel.
D. software operation fool proof mistake proofing operation
This system operating software humanization designing and, intellectuality, realize the function of intelligent fool proof mistake proofing.Mainly be that system software adopts sequential operation design, sequence of operation such as Fig. 9.
It is that step is finished whole testing process in sequence, and before the back setting was not finished, its next step operation was forbidden.Therefore have the function of the faulty operation of preventing, instrument is played the better protect effect.
Based on top characteristics, system has realized the fool proof function simultaneously.According to empirical parameter in the past, program has been carried out initialization to these controlled variable when initialization, so operating personnel can not carry out parameter and arrange, and sample introduction separation detection when directly PMT regulates the back realizes the foolization operation.
The present invention has the following advantages and effect:
1. software interface is directly perceived: the native system control program adopts VC to write, and operation interface is intuitively arranged, and is visual strong; Bottom is adopted the DLL chain program, and upgrading is convenient.
2. simple to operateization: by combining of software and hardware, it is very simple that this control mode becomes, and only controls several buttons and can finish the check and analysis process, greatly made things convenient for operating personnel, meets the original intention of family expensesization.
3. operative intelligence robotization: in some parameter regulation processes of instrument, the system control method automated intelligent has been obtained good control effect, has reduced required professional degree and the proficiency of operating personnel.
4. adopt MCU control, for " individualizing ", " family oriented ", " portability " of μ TAS steps a gratifying step, the development later for μ TAS provides experience.
Description of drawings
Fig. 1 control system and electrical signal detection system
1. high-voltage power supply is controlled 2. patterns, the 3. information acquisition processing module 4.AMC7820 chips that automatically switch
Fig. 2 relay drives the I/O schematic diagram
Fig. 3 principle of electrophoresis figure, among the figure 5 be sample cell 6 for waste liquid pool 1. 7 for buffer pool 8 for waste liquid pool 2.
Fig. 4 I/V conversion, filtering circuit
Fig. 5 detects the software operation interface of automatic control
The sensitivity adjusting dialog box of Fig. 6 photomultiplier (PMT)
Fig. 7 sample introduction separation parameter is provided with dialog box
(a) un-activation dialog box
(b) activate dialog box
Fig. 8 trace shows dialog box
Fig. 9 operational flowchart
Embodiment
Describe the structure of concrete elaboration system and realize the specific implementation method of control automatically below by embodiment.
Embodiment one:
Purchase the structure that each functional part carries out system according to designing requirement.Mainly form by parts such as burst of ultraviolel light source, collector lens, optical filter, micro-fluidic chip, light detection, microsystems.Software is installed, and can only connect to copy on any PC and move.But the PC machine must be equipped with VC6.0++ software, otherwise some DLL chained files must be installed.Simultaneously, running software button shortcut is put in desktop, is convenient to start software and tests.Initial parameter is set to after the installation:
Control voltage: PMT sensitivity adjustable voltage, can be adjustable between 0～1000mV, be initialized as 500mV;
Sensitivity is provided with: sensitivity pre-sets, can be adjustable between 0～10, be initialized as 6;
Background signal: the sample background voltage signal when sampling, shows in real time;
Sample introduction voltage: 0～+ 1000V, be initially set 500V;
Sample injection time: 0～60 second, be initially set 30 seconds;
Separation voltage: 0～+ 5000V, be initially set 2000V;
Disengaging time: 0～10 minute, be initially set 10 minutes.
Embodiment two:
When beginning to test, the micro-fluidic chip that will add analyzing samples is earlier put into the chip platform, shuts instrument window.At first regulate the sensitivity of photomultiplier, Sensitirity va1ue is set as 6 by operating personnel, push " adjusting " button and get final product fast automatic finishing, system regulates PMT automatically and trends towards designed value according to the initial setting up parameter of dialog box.
After the PMT sensitivity adjusting was finished, electrophoresis parameter dialog box was activated, and can carry out the parameter setting that sample introduction separates.According to requirement of experiment electrophoresis sample introduction voltage and time (as 500V, 30 seconds) are set respectively, separation voltage and time (as 2000V, 10 minutes).
Start detection, whole testing process realizes automatic control and treatment by program.
Claims (10)
1. mini type electrophoresis detection system of microflow control chip, comprise PC, chip, high-voltage power supply control module, pattern automatic switchover module and signal acquisition process module, it is characterized in that described chip is AMC7820, PC is realized communicating by letter of the two by 25 pin parallel ports with the single program initiator (SPI) serial ports of AMC7820 chip; The high-voltage power supply control when A/D by the AMC7820 chip and D/A function realize the micro-fluidic chip sample introduction separated and the collection of signal.
2. by the described mini type electrophoresis detection system of microflow control chip of claim 1, it is characterized in that realizing that communicating by letter of the two is to adopt two SN74AHC244PWR buffer chips between PC and AMC7820.
3. by the described mini type electrophoresis detection system of microflow control chip of claim 1, it is characterized in that system adopts the parallel port of PC to realize what digital signal was exported after the SN74AHC244PWR buffering.
4. by the described mini type electrophoresis detection system of microflow control chip of claim 1, it is characterized in that described pattern automatic switchover modular system adopts opto-coupler chip and Darlington transistor to form the driver module of relay.
5. by the described mini type electrophoresis detection system of microflow control chip of claim 4, it is characterized in that described employed opto-coupler chip is TLP504A, Darlington transistor is ULN2003A, the optically-coupled chip cuts off circuit and outside broken height is pressed high stream, and Transistor-Transistor Logic level is spread out of, carry out the power that electric current amplifies generation driving relay and reach the woods pipe, and be connected to external interface, produce relay and drive I/O.
6. by the described mini type electrophoresis detection system of microflow control chip of claim 1, it is characterized in that whole detection system adopts high-voltage DC power supply as driving force, high-voltage power supply adopts the continuous adjustable line traffic control of 0-+5V; System adopts the DAC0 and the DAC1 output aanalogvoltage of AMC7820 chip, cooperates relay to realize the high-pressure modular automatic and adjustable again.
7. by the described mini type electrophoresis detection system of microflow control chip of claim 1, it is characterized in that described information acquisition processing module is to adopt 8 rank Butterworth filtering, after filtering, carry out signals collecting by the A/D of AMC7820 chip again.
8. use the detection autocontrol method of mini type electrophoresis detection system of microflow control chip as claimed in claim 1, it is characterized in that system, adopt VC to write the automatic control that software is realized system based on described detection system; System bottom adopts the DLL chain program to write, and contains measurement sensitivity and regulates dialog box, separates sample introduction parameter dialog box, test process demonstration dialog box and four modules of sample signal curvilinear figure display box; Whole detection sequence of steps is to realize automatically that by the Set Times function startup timer interrupt routine of PC the implementation step of autocontrol method is:
(a) at first export the sensitivity adjusting that the 0-1V DC voltage is carried out photomultiplier by the AMC7820 chip, photomultiplier sensitivity adjustable voltage scope is 0-1000mV, is initialized as 500mV; Sensitivity is preset between the 0-10 adjustable, is initialized as 6;
(b) after the photomultiplier sensitivity adjusting is finished, separate sample introduction parameter dialog box and be activated, thereby carry out determining of separation parameter; During sample introduction, the sample cell and the first waste liquid pool two ends join in high-voltage power supply control module mesohigh power supply and the micro-fluidic chip, and voltage is 0～+ 1000V, be initialized as 500V, the time is 30 seconds; During separation, high-voltage power supply is connected with second waste liquid pool with buffer pool, and voltage is 0～+ 5000V, be initialized as 2000V, the time is 10 minutes;
(c) follow the start detection program, Automatic Program obtains the process parameter from dialog box, thereby realizes the high tension voltage module is controlled in the D/A output of AMC7820 chip by the SPI serial ports; Reach automatic testing goal;
(d) after AMC7820 collects signal, upload PC, and carry out being presented on the sample message curvilinear figure display box Real Time Observation testing result after digital filtering is handled with PC.
9. press the detection autocontrol method of the described mini type electrophoresis detection system of microflow control chip of claim 8, it is characterized in that described interrupt routine self-clocking, be to compare with dialog box sample introduction disengaging time parameter, thereby the automatic switchover of control sample introduction, detachment process, and finish The whole analytical process automatically after finally finishing the check and analysis process.
10. by the detection autocontrol method of the described mini type electrophoresis detection system of microflow control chip of claim 8, it is characterized in that collection of illustrative plates on information curvilinear figure display box be with the peak area representative sample in the concentration of certain composition, the big more then concentration of area is high more; At the test sample of variable concentrations, the peak area difference of appearance, system software is the difference of concentration per sample, and intelligence is adjusted spectrum mark displaying ratio automatically, thereby realizes handling automatically.
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Families Citing this family (8)
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| CN101441194B (en) * | 2008-12-25 | 2012-12-26 | 重庆大学 | Low voltage chip electrophoresis multi-section circulation type voltage exerting control system and method |
| CN102955019A (en) * | 2011-08-17 | 2013-03-06 | 北京华凯瑞微流控芯片科技有限责任公司 | Water quality on-line monitoring system and its preparation method |
| CN103604936A (en) * | 2013-11-08 | 2014-02-26 | 苏州汶颢芯片科技有限公司 | Automatic control and analysis detector for micro-fluidic chip |
| CN103616910A (en) * | 2013-12-17 | 2014-03-05 | 苏州汶颢芯片科技有限公司 | Multi-channel fluid automatic control device |
| CN104316710B (en) * | 2014-10-29 | 2016-05-04 | 邓杏飞 | The meticulous subfraction microfluidic chip system of a kind of serum lipoprotein hypotype |
| CN106160851B (en) * | 2016-09-05 | 2018-08-03 | 申瓯通信设备有限公司 | A kind of fiber optical transceiver of band OAM |
| CN111239198B (en) * | 2020-02-26 | 2022-04-22 | 湖南理工学院 | Portable micro-fluidic chip analysis diagnostic apparatus and control method |
| CN112604616A (en) * | 2020-11-17 | 2021-04-06 | 华东师范大学 | Automatic control system and method for continuous synthesis of microchemical reaction and online monitoring |
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| CN2035531U (en) * | 1988-06-18 | 1989-04-05 | 杨杰 | Optical coupling relay |
| CN1556392A (en) * | 2003-12-30 | 2004-12-22 | 中国科学院上海微***与信息技术研究 | Microbiochemical detection and analysis method and instrument |
| US20050150766A1 (en) * | 2001-11-02 | 2005-07-14 | Andreas Manz | Capillary electrophoresis microchip system and method |
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| CN2035531U (en) * | 1988-06-18 | 1989-04-05 | 杨杰 | Optical coupling relay |
| US20050150766A1 (en) * | 2001-11-02 | 2005-07-14 | Andreas Manz | Capillary electrophoresis microchip system and method |
| CN1556392A (en) * | 2003-12-30 | 2004-12-22 | 中国科学院上海微***与信息技术研究 | Microbiochemical detection and analysis method and instrument |
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| 多通道模拟监视器件AMC7820的原理及应用. 潘建.国外电子元器件，第1期. 2004 * |
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