CN100364594C

CN100364594C - Medicine for treating chronic superficial gastritis and peptic ulcer diseases

Info

Publication number: CN100364594C
Application number: CNB2006100424485A
Authority: CN
Inventors: 孟宪安; 邴艳霞; 金红; 孙绍军; 高恒强
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-02-28
Filing date: 2006-02-28
Publication date: 2008-01-30
Anticipated expiration: 2026-02-28
Also published as: CN1850237A

Abstract

The present invention relates to a drug for treating chronic superficial gastritis and peptic ulcer diseases, and belongs to oral administration Chinese drug preparations. The Chinese drug preparation is prepared by the traditional Chinese drug as raw materials by weight of raw rhubarb 3, coptis root 5, notoginseng radix 3, dandelion 15, red sage root 15, frankincense 1, scutellaria root 9, rhizome of lagehead atractylodes 6, magnolia bark 3, polygonatum 6, evodia fruit 4.5, corydalis tuber 9, astragalus root 30, phellodendron bark 12, fructus gardeniae 9, tuckahoe 10, vladimiria root 9 and prepared liquorice root 3. The compatibility of the drugs are carried out according to a synergetic drug combined method, and the present invention is prepared by traditional methods. The present invention has effective effects on killing helicobacter pylori; furthermore, lots of patients treated by administration feel good without untoward reaction, and the symptoms of acid return, etc. disappear; the fundamental cure rate of gastropathy is 87%, and effective rate is 93%. In addition, the present invention has the advantages of no stimulation to intestine and stomach, no damage to liver and no generation of drug tolerance, and is mainly used for treating the chronic superficial gastritis and the peptic ulcer diseases.

Description

A kind of medicine for the treatment of chronic superficial gastritis and peptic ulcer disease

Technical field

The present invention relates to a kind of innerwear Chinese medicine preparation, particularly treat the chronic superficial gastritis that causes by helicobacter pylori (Hp), the medicine of peptic ulcer disease.

Background technology

Existing increasing result of study confirms that helicobacter pylori (Hp) has substantial connection with the morbidity and the degree of chronic gastritis, peptic ulcer, roughly has 60% to exist Hp to infect in the chronic gastritis of China and patients with peptic ulcer.

Doctor trained in Western medicine is to the treatment of gastropathy, owing in its prescription antibiotics and tinidazole are arranged, though effect is good, but antibiotics easily develops immunity to drugs, and the tinidazole medicine is big to gastrointestinal irritation, and also there is toxicity in liver, and patient is difficult to accept.

Existing tcm methods, effect is more slow, and toxicity is little, and patient easily accepts.But there are some problems in design of compound recipe composition and dosage design.Lack of standardization as dosage, specific aim is indeterminate, thereby effect is relatively poor.

Summary of the invention

In order to overcome the problem that above-mentioned prior art exists, the purpose of this invention is to provide a kind of being not easy and develop immunity to drugs, helicobacter pylori is had the Chinese medicine medicine of effective killing effect, the chronic superficial gastritis that has no side effect again and peptic ulcer disease.

Technical scheme of the present invention is: the medicine of this kind treatment chronic superficial gastritis and peptic ulcer disease, it is characterized in that, by the Chinese medicine preparation that the raw material of Chinese medicine of following weight parts is made, Radix Et Rhizoma Rhei 3, Rhizoma Coptidis 5, Radix Notoginseng 3, Herba Taraxaci 15, Radix Salviae Miltiorrhizae 15, Olibanum 1, Radix Scutellariae 9, the Rhizoma Atractylodis Macrocephalae 6, Cortex Magnoliae Officinalis 3, Rhizoma Polygonati Odorati 6, Fructus Evodiae 4.5, Rhizoma Corydalis 9, the Radix Astragali 30, Cortex Phellodendri 12, Fructus Gardeniae 9, Poria 10, Radix Vladimiriae 9, Radix Glycyrrhizae Preparata 3.

Dosage form: can be said any dosage form on the pharmacy of Chinese materia medica.

Contraindication: gastric perforation the person do not use.

Instructions of taking: twice on the one, service once night at noon, every pair (gram), Radix Et Rhizoma Rhei 3, Rhizoma Coptidis 5, Radix Notoginseng 3, Herba Taraxaci 15, Radix Salviae Miltiorrhizae 15, Olibanum 1, Radix Scutellariae 9, the Rhizoma Atractylodis Macrocephalae 6, Cortex Magnoliae Officinalis 3, Rhizoma Polygonati Odorati 6, Fructus Evodiae 4.5, Rhizoma Corydalis 9, the Radix Astragali 30, Cortex Phellodendri 12, Fructus Gardeniae 9, Poria 10, Radix Vladimiriae 9, Radix Glycyrrhizae Preparata 3, be decocted in water for oral dose or obey form of Chinese drug such as the oral liquid consistent, capsule with this dosage, other is taking medicine before meal one ball ranitidine sooner or later, and one month is a course of treatment.Need to prove that Radix Notoginseng also can take after mixing it with water separately.

Pharmacological effect: originally whether the original-party for this compound recipe of checking is effective to Hp, the original-party decoct is used for the Bacteriology Room experiment, method is to take from the gastric tissue that contains Hp that the patients with gastric disease of getting is clamped in hospital gastroscope chamber, the city, extract Hp and cultivate, experimentize with the original-party medicament then, experimental group does not have any strain growth as a result, and matched group has a large amount of bacterial reproductions, after medicament diluted half, a few strain bacterial isolateses then appearred in experiment again.Original-party is: Radix Et Rhizoma Rhei 3g, Rhizoma Coptidis 3g, Radix Notoginseng 3g, Herba Taraxaci 12g Radix Salviae Miltiorrhizae 15g, Olibanum 1g, Radix Astragali 3g, Rhizoma Atractylodis Macrocephalae 3g, Radix Paeoniae Alba 3g, Cortex Magnoliae Officinalis 3g, Radix Ophiopogonis, 10g, Rhizoma Polygonati Odorati 10g, Fructus Evodiae 6g, Herba Hedyotidis Diffusae 10g, Rhizoma Corydalis 10g, Radix Glycyrrhizae Preparata 3g, Song Xiren etc. were with refining alcohol extraction rhubarb tablets (every 0.25 gram, be equivalent to crude drug 1g) 3～4, three times on the one treatments, the Hp negative conversion rate is 36.9%, and this original-party to kill the medicine of Hp all be low dose of, and Hp and other antibacterial all can be killed, illustrate that this original compound recipe has collaborative summation action to the killing action of Hp.

Through considering that Herba Hedyotidis Diffusae is owing to the medicine that is the treatment tumor, and the medicine of treatment tumor has the tendency that easily causes tumor, so remove, Radix Ophiopogonis is owing to there is the people to have irritated situation to take place, so also deleted, some drug dose does not meet the pharmacopeia standard, and being adjusted (most anti-Hp drug doses are strengthened) increases Radix Scutellariae, Cortex Phellodendri, Fructus Gardeniae, Poria, the anti-Hp medicine of the Radix Vladimiriae five tastes again, thereby makes the anti-Hp of compound recipe of new adjustment render a service more powerful.Under the state of gastric content dilution, Hp is still had killing action.

This new compound efficacy of a drug is that the medicine except the Rhizoma Atractylodis Macrocephalae, Cortex Magnoliae Officinalis, Rhizoma Polygonati Odorati, Poria all has in various degree killing action to Hp.Rhizoma Coptidis has antiulcer and suppresses the gastric secretion effect.Radix Notoginseng hemostasis dissipating blood stasis for subsidence of swelling.The Herba Taraxaci antiulcer action is obvious.Radix Salviae Miltiorrhizae strengthens the gastric mucosal barrier effect and suppresses stomach motion effect, alleviates gastric mucosa injury, and the Radix Astragali also has inducing interferon and regulates the effect of antibody mediated immunity function.Radix Scutellariae has the effect of extremely strong antiinflammatory and antiallergic action.But Olibanum blood circulation promoting and blood stasis dispelling.The Rhizoma Atractylodis Macrocephalae is effective to stress gastric ulcer, and antiinflammatory action is arranged.The Radix Paeoniae Alba has loose and inhibitory action to the tension force and the motion of pipe smooth muscle, and various bacteria is had inhibitory action, promotes enzyme system and immune resistance against diseases.Cortex Magnoliae Officinalis can produce antiulcer action by the inhibitory action of central (secretion).Also has anti-allergic effects.Rhizoma Polygonati Odorati is longer than yin nourishing.Fructus Evodiae be beneficial to the five internal organs help digestion long-pending, dispersing cold for relieving pain, the preventing or arresting vomiting warming middle-JIAO to stop diarrhea of regulating the flow of vital energy, acid regurgitation, antibiotic expeling gastric qi, suppress enteral abnormal fermentation, also have sedation preferably.Rhizoma Corydalis reduces gastric secretion, reduces gastric acid and pepsic amount, and gastric ulcer and duodenal ulcer are had excellent curative.Cortex Phellodendri has antiinflammatory action, and Fructus Gardeniae also can suppress gastric secretion, and the stomach total acidity is reduced, and function of gallbladder promoting, platelet aggregation effect due to the ADP of inhibition, collagen, the epinephrine is arranged.The removing dampness of Poria replenishing QI to invigorate the spleen, Radix Aucklandiae regulating qi-flowing for harmonizing stomach.Radix Glycyrrhizae Preparata is used for all cards of deficiency of spleen-QI and stomach-QI, is in harmonious proportion hundred medicines, alleviates the pipe smooth muscle spasm, and the gastric juice of inhibition and pepsinia are arranged, and promotes tissue regeneration, and gastric ulcer and duodenal ulcer face are had protective effect.

The present invention is directed to Hp and adopt the cocktail type combination.So-called cocktail type combination is new drug development pattern--" cooperative drug combination type " new therapeutic agent that was proposed by doctor of medicine Mr. He Dayi of Chinese origin from 2000.It is just various old medicines with science mode compatibility, can develop the novel cooperating type drug regimen new drug of the difficult smelting disease of multiple treatment (comprising non-fatal diseases such as tumor, acquired immune deficiency syndrome (AIDS), Alzheimer, tuberculosis, leprosy and psoriasiss).Effect of the present invention also has benefited from " cooperative drug combination type " this theory.

The invention has the beneficial effects as follows: helicobacter pylori is had effective killing effect, and patient takes treatment to many cases, feels good, and has no adverse reaction, and returns transference cures such as acid after controlling, and the gastropathy eradication rate is 87%, effective percentage 93%.This prescription is made up of pure Chinese crude drug, and the intestines and stomach is not had any stimulation, to not damage of liver, does not produce drug resistance, and patient is easy to receive treatment.For this effect is described, now the clinical experiment situation is described as follows:

Only in year May in October, 2003 to 2005, the author adopts we's treatment chronic superficial face and each 30 example of gastroduodenal ulcer patient.Classical symptom and medical history that superficial gastritis or gastroduodenal ulcer are all arranged are divided into two groups at random, and 30 examples are organized in treatment, matched group 30 examples, and matched group adopts omeprazole, clarithromycin, tinidazole, and dosage and method are taken routinely.Experimental group adopts respectively obeys a ranitidine sooner or later half an hour ante cibum, service once compound recipe decoction of the present invention before the lunch and before sleeping evening: Radix Et Rhizoma Rhei 3g, Rhizoma Coptidis 5g, Radix Notoginseng 3g, Herba Taraxaci 15g, Olibanum 1g, Radix Scutellariae 9g, Rhizoma Atractylodis Macrocephalae 6g, Radix Paeoniae Alba 6g, Cortex Magnoliae Officinalis 3g, Rhizoma Polygonati Odorati 6g, Fructus Evodiae 4.5g, Rhizoma Corydalis 9g, Radix Astragali 30g, Cortex Phellodendri 12g, Fructus Gardeniae 9g, Poria 10g, Radix Vladimiriae 9g, Radix Glycyrrhizae Preparata 3g, therapeutic outcome shows, ulcer healing and gastric mucosa healing there are no significant difference under the Hp eradication rate of treatment group and matched group and the gastroscope, but an example only appears in side reaction treatment group, far below 16 examples of matched group.The side reaction of treatment group does not influence and continue treatment, and serious adverse effects appears in matched group 6 examples, has to end treatment only for times of defecation increases.Treatment group Hp eradication rate is 87%, effective percentage 93%.

Case one: patient man 35 years old, December in 2003 first visit on the 2nd.Gastral cavilty distending pain first quarter moon, noisy, acid regurgitation, the vexed discomfort of painful abdominal mass, loss of appetite, the little Huang of light red tongue greasy fur, rolling pulse.Gastroscopy, gastric antrum portion erosive gastritis is given medicine of the present invention, and take ranitidine one ball half an hour before the supper early, serve on 7 doses, and pain relief is advanced 15 doses again, and all diseases disappear.

Case two: patient, man, 47 years old, first visit on February 5 in 2004, gastral cavilty portion distending pain is 10 years repeatedly, successively takes ranitidine, Western medicine such as bismuth aluminate compound, but still outbreak repeatedly, gastral cavilty portion dull pain and distension discomfort again, anorexia and loose stool, refreshing tired weak, lusterless complexion, the light red tongue white and thin fur, thready pulse, gastroscopy: (1) chronic superficial gastritis (2) duodenal bulbar ulcer; Serve on 15 doses by this decoction, join ranitidine simultaneously, behind the first quarter moon, symptom subtracts greatly, and diet increases.The continuous transference cure in January of controlling.

Case three: patient, woman 50 years old.Examine on May 30th, 2003.Patient's gastralgia 3 years increased the weight of in nearly 1 month, and disease is seen the indistinct causalgia of gastral cavilty portion, drank and loss of appetite, swallow in dry mouth, give birth to skin ulcer in mouthful, constipation, 2 to 3 are once, once examined do gastroscopy and be " chronic superficial gastritis ", part body of gland atrophy red tongue tongue is few and dried, thready and rapid pulse, serve on 5 doses with this prescription, two examine stomachache alleviates, and aphtha heals, defecate down, tongue fur gradually moistens, and obeys 15 doses again, all diseases are known flatly behind the medicine, and 15 doses of defences are to consolidate curative effect.

Case four: patient man, 57 years old.Examine on July 28th, 2003, gastralgia is shown effect surplus in the of 20 year repeatedly, increases the weight of January, and disease is seen vague epigastralgia, night slightly very, general vomiting watery fluid, anorexia, The stool is completely mashed, weak lazy speech, pale tongue with white fur, deep-thready pulse, gastroscopy is examined and is chronic superficial gastritis.Give 10 doses of we, pain disappears, and mouthful little dried hardship is obeyed 15 doses again, and symptom is stable.

The specific embodiment

A kind of medicine for the treatment of chronic superficial gastritis and peptic ulcer disease, by the Chinese medicine preparation that the raw material of Chinese medicine of following weight parts is made, Radix Et Rhizoma Rhei 3, Rhizoma Coptidis 5, Radix Notoginseng 3, Herba Taraxaci 15, Radix Salviae Miltiorrhizae 15, Olibanum 1, Radix Scutellariae 9, the Rhizoma Atractylodis Macrocephalae 6, Cortex Magnoliae Officinalis 3, Rhizoma Polygonati Odorati 6, Fructus Evodiae 4.5, Rhizoma Corydalis 9, the Radix Astragali 30, Cortex Phellodendri 12, Fructus Gardeniae 9, Poria 10, Radix Vladimiriae 9, Radix Glycyrrhizae Preparata 3.

Compatibility of drugs is by " cooperative drug combination type "; By the traditional method preparation.Dosage form: can be said any dosage form on the pharmacy of Chinese materia medica.

Claims

1. medicine for the treatment of chronic superficial gastritis and peptic ulcer disease, it is characterized in that, by the Chinese medicine preparation that the raw material of Chinese medicine of following weight parts is made, Radix Et Rhizoma Rhei 3, Rhizoma Coptidis 5, Radix Notoginseng 3, Herba Taraxaci 15, Radix Salviae Miltiorrhizae 15, Olibanum 1, Radix Scutellariae 9, the Rhizoma Atractylodis Macrocephalae 6, Cortex Magnoliae Officinalis 3, Rhizoma Polygonati Odorati 6, Fructus Evodiae 4.5, Rhizoma Corydalis 9, the Radix Astragali 30, Cortex Phellodendri 12, Fructus Gardeniae 9, Poria 10, Radix Vladimiriae 9, Radix Glycyrrhizae Preparata 3.

2. a kind of medicine for the treatment of chronic superficial gastritis and peptic ulcer disease according to claim 1 is characterized in that described dosage form is said any dosage form on the pharmacy of Chinese materia medica.