CN100364576C - Vagina applied Chinese medicinal preparation for treating profuse leukorrhea and cervical erosion and preparation method thereof - Google Patents
Vagina applied Chinese medicinal preparation for treating profuse leukorrhea and cervical erosion and preparation method thereof Download PDFInfo
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- CN100364576C CN100364576C CNB200510036624XA CN200510036624A CN100364576C CN 100364576 C CN100364576 C CN 100364576C CN B200510036624X A CNB200510036624X A CN B200510036624XA CN 200510036624 A CN200510036624 A CN 200510036624A CN 100364576 C CN100364576 C CN 100364576C
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Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a traditional Chinese medicine preparation for treating vaginas of women in large leukorrhea and cervical erosion. Main components of the present invention comprises alums (calcining), bitter apricot kernels and bee honey; the main components are made into suppositories, gels, effervescent suppositories or effervescing agents, etc. The preparation has the functions of dehumidifying, detoxicating, destroying parasites and elieving itching, and can treating large leukorrhea and cervical erosion. The prescription and the composition of the preparation of the present invention have the advantages of novel conception, simple production method, easy use, obvious curative effects.
Description
Technical field
The vagina that the present invention relates to a kind of women's of treatment profuse leukorrhea, cervical erosion is with prescriptions of Chinese medicine and preparation and production method thereof.
Background technology
Profuse leukorrhea, cervical erosion are one of modal a kind of gynaecopathias of the women of child-bearing age, and according to theory of Chinese medical science, this disease belongs to the category of leukorrheal diseases, and its paathogenic factor mainly contains three aspects.1, insufficiency of the spleen mistake fortune, downward flow of dampness forms leukorrhagia; 2, the leukorrhagia that suffer from a deficiency of the kidney admittedly, the deficiency of YIN intimately causes; 3, Yu Huare makes a bet in the damp, or the heresy of, noxious dampness damp and hot through the row puerperal infection and cause leukorrhagia.Cervical erosion, disease is seen: profuse leukorrhea, color or white or sallow or yellowish, matter is sticky, shape that has such as foam, shape that has such as bean dregs or curdled milk, abnormal smells from the patient is smelly dirty, and pudendal pruritus is arranged more.
The medicine and the method for this disease of treatment are more at present, and Western medicine is based on antibiotic, and its side effect is bigger; Chinese medicine preparation is with its determined curative effect, and is easy to use, and toxic and side effects is little occupies crucial status on clinical treatment.Open source literature had once been reported the content of some Chinese medicine preparation treatment women profuse leukorrheas, cervical erosion, as:
1.[autograph] the journal .2000 of Ningxia Medicine College of the beautiful prunus mume (sieb.) sieb.et zucc. [mechanism] of observation of curative effect [author] Fu Lan Fangan Zhongning County, Ningxia hospital [periodical name] of treatment by Chinese herbs cervical erosion, 22 (3) .-221-222[digests] the rotten to the corn patient in palace is through the treatment by Chinese herbs curative effect in various degree to observe 216 examples, and Chinese drug-treated group becomes Alumen, Realgar, Semen Armeniacae Amarum, Olibanum, Myrrha, Borneolum Syntheticum.As a result, 210 examples are cured cure rate 97.6% in 216 examples.Think and are easy to easy, the easy row of this method, good effect carry out using at basic hospital.
2.[autograph] Chinese medicine Chinese medicine leukorrheal diseases 180 worker's hospitals of the example observation strong Tian Fengqin of [author] old treasured [mechanism] Yumen Petrol Administration, [periodical name] practical Chinese medicine magazine .2004,20 (11) .-611-611[digests] purpose: the clinical efficacy of observing oral medicinal herb washout treatment leukorrheal diseases.Method: with subtracting the external fumigation and washing side's treatment of cooperation Chinese medicine from intending ending stagnant Tonga, 7 is a course of treatment, treats 1～3 course of treatment to 180 routine patients.Basis side for oral administration: Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, each 15g of Semen Plantaginis (bag), Rhizoma dioscoreae (parched) 30g, Herba Schizonepetae (parched) fringe, each 10g of the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, each 12g of Rhizoma Polygoni Cuspidati, Radix Bupleuri, each 6g of Radix Glycyrrhizae.Heating person adds Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, and the weakness of the spleen and stomach person adds Radix Codonopsis, the Radix Astragali, Poria.Lumbago due to renal deficiency person adds Radix Dipsaci, parasitism, Cortex Eucommiae (parched).The obvious person of deficiency of the kidney yin symptom adds Fructus Ligustri Lucidi, Fructus Lycii, Herba Ecliptae, the obvious person of insufficiency of kidney-YANG symptom adds Cornu Cervi Degelatinatum, Herba Cistanches, Semen Cuscutae, damp and hot obvious person Jia Rhizoma Dioscoreae Septemlobae, Herba Patriniae, Radix Gentianae, pyretic toxicity weight person adds Herba Taraxaci, Herba Hedyotidis Diffusae, Chinese toon root white skin, cold coagulation stomachache person adds Fructus Foeniculi, Folium Artemisiae Argyi, SHIXIAO SAN, the person adds Radix Angelicae Sinensis, Rhizoma Chuanxiong, Herba Leonuri congestion, and leukorrhagia with the passing of time, the more than person of slippage adds Fructus Rosae Laevigatae, Semen Euryales, Os Sepiae etc., and drug dose slightly adjusts with the patient age state of an illness.Decocting 2 times, extracting juice divides decoction being taken warmly sooner or later 2 times, and 1 dose of every day, 7 days is a course of treatment, and withdraw menstrual period.External fumigation and washing side: Radix Sophorae Flavescentis 30g, Cortex Dictamni, Fructus Cnidii, Radix Stemonae, each 15g of Cortex Phellodendri, dried Alumen end 10g.Grinding coarser powder is 1 staggering amount, adds water 1500ml and fries in shallow oil to about 1000ml, removes slag to pour the external genital of fumigation and wash method demibain while hot in the basin into, each 20～30min, every day 1～2 time, 7 is a course of treatment, all withdraw other any medicines during the treatment, 1～3 course of treatment of continuous use, statistics curative effect.The result: cure 110 examples, 56 examples that take a turn for the better, 14 examples that do not heal, total effective rate is 92.2%.Conclusion: Chinese medicine Chinese medicine leukorrheal diseases are evident in efficacy.
3.[autograph] the LIUSHEN WAN external Alumen Cacumen Platycladi treatment herpes zoster 63 Li Cha town 266324[of commune hospital of routine observation of curative effect [author] An Yue [mechanism] Jiaozhou City, Shandong Province periodical name for oral administration] the Chinese doctor of community: general news column .2004,6 (2) .-49-49[digests] this group has 63 examples, divide treatment to organize 37 examples, matched group 26 examples now are described below its concrete Therapeutic Method.
4.[autograph] the Shaanxi traditional Chinese medical science .2000 of the People's Hospital, treatment by Chinese herbs leukorrheal diseases 348 examples [author] Sun Xiaodong [mechanism] Gaochun County, Jiangsu Province [periodical name], 21 (12) .-539-539[digests] adopt from intending 348 examples under prescription (Cornu Cervi Degelatinatum, Fructus Corni, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, the Herba Leonuri etc.) treatment belt, total effective rate 95.9%, the prompting we have the kidney invigorating, the astringent or styptic treatment for spontaneous sweating effect of dehumidifying, the just logical fortune of holding back is one, is the effective ways of removing leukorrhagia.
5.[autograph] homemade traditional Chinese drug suppository treatment cervical erosion 360 routine efficacy analysis [author] Wang Qin [mechanism] Zaozhuang City institutes of traditional Chinese medicine, [periodical name] Chinese natural medical journal .2003,5 (1) .-52-52[digests] prescription source and form the prescription source: the old docter of TCM on the basis of proved recipe " loosing in the moon palace ", after the toxicology test proof has no side effect, make suppository by the Drug Manufacturing Room of the court.Side's medicine is formed: Borax 20g, dried Alumen 10g, catechu 10g, Sanguis Draxonis 5g, Olibanum 10g, Myrrha 10g, Borneolum Syntheticum 3g, Radix Sophorae Flavescentis 15g, Indigo Naturalis 10g, Fructus Cnidii 15g, Os Draconis (calcined) 20g.Make suppository by this dosage, every content is about 2g.
6.[autograph] Chinese medicine suppository treats chronic cervical erosion 40 routine clinical observation [author] Fan Xiaoling [mechanism] Shuande, Guangdong Province city Gui Zhou hospital, [periodical name] Jiangxi Chinese medicine .2003,34 (1) .-23-23[digests] compound hippophae rhamnoides seed oil bolt main component has Semen Fructus Hippophae oil, Fructus Cnidii, Radix Sophorae Flavescentis, Calamina, Myrrha, Olibanum etc.Wherein Semen Fructus Hippophae oil, Fructus Cnidii, Radix Sophorae Flavescentis heat clearing and damp drying have the effect of eliminating cervical erosion face inflammation, reducing inflammatory exudation; Calamina convergence granulation promoting; Olibanum, Myrrha promoting blood circulation and detumescence granulation promoting, the human body immunity improving function.Promote regeneration, the healing of rotten to the corn covering weave.By controlled observation, the Chinese medicine suppository good effect, safety, convenient, side effect is little, be worth clinical and be extensive use of
7.[autograph] the Chinese medicine vagina effervescence builds [mechanism] Tianjin College of Traditional Chinese Medicine such as the tinkling of pieces of jade to effect [author] the Hu Xiaohui king of cervical erosion rat IL-6TNF-α, [periodical name] Liaoning Journal of Traditional Chinese Medicine .2002,29 (8) .-507-508[digests] purpose: inquire into Chinese medicine medicine for external use vagina effervescence to cervical erosion experimental rat IL-6, the effect of TNF-α.Method: experimental rat is divided into the modeling group, the treatment group, matched group, all laboratory animal is carried out pathological examination and IL-6, the determination of activity of TNF-α.The result: the visible down a large amount of cell infiltration of pathological examination, modeling group cervical mucosa, mucosal ulcer appears in little vasodilation, the treatment group, the above-mentioned pathological change of matched group is not obvious, IL-6, TNF-α measurement result; Modeling group IL-6, TNF-alpha levels be apparently higher than matched group, treatment by Chinese herbs group IL-6, and the TNF-alpha levels is starkly lower than the modeling group, IL-6 between treatment group and matched group, TNF-alpha levels no significant difference.Discuss; The Chinese medicine vagina effervescence is to the too high IL-6 of cervical erosion experimental rat, and the TNF-alpha levels has obvious regulating action.Thereby corresponding pathological change is improved.
8.[autograph] clinical research-attached 625 case reports [author] of Chinese medicine vagina effervescence treatment cervical erosion breathe out the Tianjin traditional Chinese medical science .2001 of [mechanism] Tianjin College of Traditional Chinese Medicine Academies of Traditional Chinese Medicine such as the virtuous Wang Ling of filial piety [periodical name], 18 (3) .-5-7[digests] use the Chinese medicine vagina effervescence and treat 625 routine patients of cervical ruin, and treat 210 examples with Western medicine rice rather effervescent vaginal tablet and carry out curative effect relatively, the result shows, treatment group cure rate is 79.20%, total effective rate 97.60%, curative effect obviously is better than matched group, the curative effect of treatment group and granular pattern erosion rotten to the corn to moderate is also apparently higher than matched group, in addition, the cure rate of treatment group, cardinal symptom is improved and late result is excellent than matched group also, the Chinese medicine vagina effervescence has heat clearing and damp drying, removing toxic substances and promoting subsidence of swelling, the effect of putrefaction-removing granulation-promoting, can eliminate the cause of disease, improve local blood circulation, remove slough, promote the healing of rotten to the corn face.
9.[autograph] Chinese medicine controls Mi Lingshuan treatment cervical erosion 150 examples and analyzes [author] Zhou Minxia [mechanism] Wujin, Jiangsu Province city institutes of traditional Chinese medicine, [periodical name] occupation and healthy .2001,17 (9) .-120-120[digests] to control rotten clever bolt Main Ingredients and Appearance be catechu, Radix Sophorae Flavescentis, Borneolum Syntheticum, dried Alumen, Cortex Phellodendri etc., it can improve vaginal environment, pH value is 3.5～4.5, proper normal acid-base value with vagina. make vagina keep normal sour environment, thereby suppress breeding and the growth of pathogenic bacteria.Control Mi Ling slowly dissolving under the human body normal body temperature; form protectiveness medicine film on rotten to the corn surface; prevent the pathogenic bacteria intrusion; this suppository has bacteriostasis in addition; improve the ability of cytophagy pathogenic bacteria, to the gram positive bacteria, the escherichia coli that cause cervical erosion and cause colpitic mycete, infusorian that extremely strong inhibitory action is arranged.Control rotten clever suppository and also have the putrefaction-removing granulation-promoting effect, rotten to the corn layer inflammatory body of gland is thoroughly destroyed, coagulated protein is arranged, suppress glandular secretion, reduce the rheuminess thing, make the effect of cervix uteri dry tack free.Simultaneously can also increase rotten to the corn position blood circulation, promote the regeneration of cervix uteri squamous epithelial cancer, accelerating wound healing has the special effect of putrefaction removing life.
10. Chinese patent [title] compound seabuckthorn fruit oil suppository [application (patent) number] 02114512.1[applies for (patent right) people] eastern section, Qindu District century main road, Haitian Pharmacy Co., Ltd., Shaanxi [address] Xianyang, Shanxi province city [summary] the invention provides a kind of cervical erosion, colpitic medicaments compound seabuckthorn fruit oil suppository that is used for the treatment of due to the damp invasion of lower energizer.It is with prescriptions such as Fructrs Hippophae seed oil, Fructus Cnidii, Radix Sophorae Flavescentis, Myrrhas, and all medicines cooperate, QI and blood regulating, and the combination of inner and outside, giving birth to dispels lays equal stress on treating both the principal and secondary aspects of a disease.Have heat clearing and damp drying, killing parasites for relieving itching, reducing swelling and alleviating pain, blood activating and promoting tissue regeneration.Is 49.3% through the clinical observation proof to treatment cervical erosion cure rate, total effective rate 94.9%; Colpitis mycotica cure rate 88.6%; Trichomonal vaginitis cure rate 89.5%.Senile vaginitis cure rate 60%, effective percentage 97.5%.And the healing at sexually transmitted disease (STD) postoperative, cervical erosion postoperative (behind laser and the electric cautery), artificial abortion's postoperative damage position there is obvious facilitation.
The Chinese medicine preparation of above-mentioned open source literature report is many to treatment women leucorrhea respectively, and cervical erosion all has certain therapeutical effect, and some therapeutic effect is also fairly good.But because to the criterion difference of drug effect, we can not be simply come different prescriptions, medicine are estimated and compared with cure rate.Understand at present according to us and yet to exist like this or what kind of weak point in these products, as: the efficient functional that has is single, can only take stopgap measures to effect a permanent cure; The prescription complexity, the dosage that have are big, cause easily that the dry and astringent and medicine of bright road is excessive and produce side effect such as skin allergy.
Summary of the invention
The technical problem that purpose of the present invention will solve provides that a kind of prescription is simple, drug dose is little, safe in utilization, cost is low, and the vagina Chinese medicine preparation that treatment women leucorrhea is many, cervical erosion has good efficacy remedies the deficiency of similar medicine.
Chinese medicine preparation of the present invention is to make with the raw material of Chinese medicine of following weight fraction:
Alumen (forging) 0.15～0.30 Semen Armeniacae Amarum 0.10～0.20 Mel 0.10～0.20
Can make pharmaceutically common gynaecologic vaginal preparations such as suppository, gel, type of effervescent suppository, effervescent tablet with above-mentioned raw material of Chinese medicine.These formulation products have the function of removing dampness and detoxicating, killing parasites for relieving itching, be applicable in the damp that Yu Huare makes a bet or due to the damp and hot noxious dampness of row puerperal infection profuse leukorrhea, and the healing that can impel the cervical erosion face.
Below be described in detail the preparation method of suppository, gel, type of effervescent suppository, effervescent tablet respectively:
1, the preparation of suppository:
Alumen (forging) is dry, pulverize, sieve (calcining is to carry out according to the method for Chinese medicine books record); Semen Armeniacae Amarum is removed the peel, pulverizes, sieved; Suppository base fusing back adding Semen Armeniacae Amarum powder and Alumen (forging) powder are stirred, other adds Mel after getting part suppository base heat fused, and add other adjuvant as required, then above two kinds of medicinal liquids are mixed, grind repeatedly to seal behind perfusion after the uniform and smooth, the cooling forming with colloid mill and promptly get suppository;
Described substrate is fat-soluble substrate such as mixed fatty glycerides, cocoa ester; Other adjuvant can be regulators such as lanoline, propylene glycol, also can add antioxidant.
2, the preparation of gel:
Alumen (forging) is dry, pulverize, sieve; Semen Armeniacae Amarum is removed the peel, pulverizes, sieved; The gel substrate heating is made dissolving and makes about 1～5% aqueous solution; Successively Alumen (forging) powder, Semen Armeniacae Amarum powder, Mel are added in the above-mentioned solution, and can add other adjuvant as required, grind repeatedly with colloid mill, regulate pH value to 6～7 with alkali after the uniform and smooth, packing promptly gets gel after sealing.
Described substrate is carbomer class or cellulose derivative compounds, and other adjuvant can be regulator and antiseptic such as ethanol, glycerol, Polysorbate, ethyl hydroxybenzoate; Alkali can be sodium hydroxide, sodium bicarbonate, triethanolamine etc.
3, the preparation of type of effervescent suppository:
Alumen (forging) is dry, pulverize, sieve; Semen Armeniacae Amarum is removed the peel, pulverizes, sieved; Suppository base fusing back is added Semen Armeniacae Amarum powder, Alumen (forging) powder and organic acid stir, grind after the uniform and smooth standby repeatedly with colloid mill; Other gets Mel, the sodium bicarbonate that adds after the part suppository base heat fused after processed, and adds other adjuvant as required, and the back that stirs merges with above-mentioned medicinal liquid, seals behind stir back perfusion, the cooling forming and promptly gets effervescent suppository;
Described substrate can be used water-soluble basees such as Polyethylene Glycol, polyoxyethylene stearate (40) fat; Other adjuvant can be regulators such as ethanol, propylene glycol, Polysorbate, also can add antioxidant; Organic acid is citric acid, tartaric acid etc.
4, the preparation of effervescent tablet:
Alumen (forging) is dry, pulverize, sieve; Semen Armeniacae Amarum is removed the peel, pulverizes, sieved; Add suitable adjuvant and mix from vitriol (forging) powder, Semen Armeniacae Amarum powder, Mel, moistening, granulate, oven dry, and then add that foaming agent and suitable adjuvant carry out that secondary is granulated, oven dry, add tabletting behind the suitable adjuvant again, promptly get effervescent tablet.
Described adjuvant is dehydrated alcohol, lactose, polyvinylpyrrolidone, starch, magnesium stearate etc.; Used foaming agent is organic acid and sodium bicarbonate such as citric acid, tartaric acid.
The suppository that the present invention makes with raw material of Chinese medicine is a kind of fat-soluble suppository, and this medicine can dissolve rapidly under the effect of body temperature after putting into vagina; Gel is the gel made from water-soluble base, and this medicine can be dissolved by vaginal secretion after putting into vagina.Type of effervescent suppository and effervescent tablet are owing to contain sodium bicarbonate and organic acid, acid behind the chance water, alkali produce chemical reaction and emit a large amount of carbon dioxides, it not only can promote the disintegrate of medicine, and this gas can form thick foam with medicinal liquid in vagina, helps the distribution and the absorption of medicine.Can be optionally after these medicaments dissolve form one deck medicine film and the playing a role of persistence at the cervical erosion face, this medicine has stronger removing dampness and detoxicating, killing parasites for relieving itching effect, the patient used the back just can control inflammation and reduce leucorrhea in 1～2 day, can impel the healing of cervical erosion face after 1～2 course of treatment.
Below be the effect of each raw material of Chinese medicine preparation of the present invention and the mechanism of curing the disease:
Alumen, head is stated from the Sheng Nong's herbal classic, and original name Alumen because of its water white transparency, is Alumen again.Alumen is the aluminum potassium sulfate that contains water of crystallization, and its different name is a lot, just like Alumen, alunite stone, plumage alunite, plumage pool, stone alunite, Gypsum Fibrosum, Bai Jun, snow vitriol, Muscovitum vitriol etc.Slough after Alumen is forged that water of crystallization claims dried Alumen, alumen ustum, processs Alumen, Ba Shi etc., the Alumen behind the calcine has removing dampness and holds back skin ulcer, rotten, the insecticidal function of hemostasisization, can treat leukorrhagia, skin infection, eczema.It all has inhibition and killing action to antibacterial (as: staphylococcus aureus, group B streptococcus, bacillus pyocyaneus, Bacillus proteus, gonorrhea diplococcus etc.), fungus (as: Candida albicans, trichophyton, achorion, epidermophyton rubrum) and trichomonas vaginitis, and it also has the effect of stronger solidifying protein outward, can restrain wound, impel ulcer surface incrustation healing.China's traditional medicine Alumen commonly used simply or with other Chinese herbal medicine compatibilities, can treat some diseases.
Semen Armeniacae Amarum, be the dry mature seed of plant Prunus armeniaca L.var.ansu Maxim., prunus mandshuricaKoehne, Siberia Fructus Pruni, Fructus Pruni, Semen Armeniacae Amarum bitter in the mouth, warm in nature is gone into lung, large intestine channel, bitter in the mouth warm in nature, can fall and to loose, its medicinal function " energy that dispersing wind-cold is arranged has the therapeutic method to keep the adverse QI flowing downwards to remove the power of breathing heavily again; the edge suffering is then loose evil; hardship is the therapeutic method to keep the adverse QI flowing downwards then, and profit is then logical secret, the Wen Zehang disease "; Ancient times, pharmacy man Li Shizhen (1518-1593 A.D.) was said: " Semen Armeniacae Amarum can loose and can fall, so but the diffusing wind of resolving depression, sending down the abnormal ascending QI is moisturized." the modern TCM medicine with Semen Armeniacae Amarum as medicine for the treatment of cough and asthma.Studies have shown that amygdalate effective ingredient is its contained amygdalin, its pharmacological action is: amygdalin through the effect of gastric acid, produces the hydrocyanic acid of trace gradually in digestive tract, respiratory center is sedation, makes respiratory movement be tending towards quiet.But, time spent can not produce toxic action to human body outside, as suppository and effervescent, it plays the growth of Aspergillus flavus and aspergillus versicolor and restrains growth, reduce inflammatory exudate, improve local blood circulation, promote the absorption of inflammation, the reaction of reducing inflammation property, suppress effects such as the granulomatous formation of inflammatory, the research worker that has finds that also Semen Armeniacae Amarum also has the transparent sample mucin tunicle that helps body endotrypsin digestion cancerous cell, make the more accessible cancerous cell of leukocyte in the body. and engulf cancerous cell, reach antineoplastic action.
Mel is that Apis is gathered the Mel that leads to behind the pollen, just brilliant edible as sugar widely since ancient times by people, China's ancient medicine treatise more uses Mel as important medical material, it is that invigorating middle warmer is moisturized that most Chinese medicine books are all introduced the Mel effect, the detoxifcation pain relieving, can treat deficiency of YIN of the spleen and stomach, dryness of the intestine constipation, epigastric pain, have moisturize, antipruritic, Detoxication, people with its as the refining pill and the modulation hundred medicines blender.Mel mineral, aminoacid, vitamin content enrich, and are beneficial to the intestines and stomach, are beneficial to health, in secular practical experience of life, people recognize, Mel be unique in the world can putrid food, natural ripe Mel seals at room temperature that to put the several years rotten to long-term storage also imputrescibility.This fact attracts much attention for a long time, and the Sri Lanka in ancient times, Greece and Roman once used food such as Mel pickle meat, not only can be anticorrosion, and can keep the delicious food of food.It is documented that the spy of foreign scholar nation once studied the Mel streptococcus of 131 kinds of different cultivars and the bacteriostasis of staphylococcus aureus, when containing 25% Mel in the agar culture medium, these two kinds of coccuses all are suppressed fully.(1995) such as the Wang Eryi of China, Wang Huajie are also verified, Mel without heating all has bactericidal action to suppurative staphylococcus aureus, beta hemolytic streptococcus, bacillus pyocyaneus, part escherichia coli, clinical sweet liquid is diluted to concentration respectively 80%, 60%, 40% with nutritious soup, 20% and 10% solution. observe the various antibacterials that variable concentrations honey liquid infected 102 routine patients (staphylococcus epidermidis 20 examples wherein, staphylococcus aureus 3 examples, escherichia coli 21 examples, bacillus pyocyaneus 15 examples, Bacillus proteus 8 examples.Klebsiella pneumonia 6 examples, dysentery bacterium 10 examples, typhoid fever, Salmonella paratyphi 8 examples, streptococcus 9 examples, mycete 2 examples) antibiotic inhibitory action.Honey density was at 40% o'clock as a result, and most of antibacterial is suppressed; Concentration was at 60% o'clock, and pyococcus and streptococcus subcultivation after cultivating in 24 hours is observed does not have 1 example existence, and the most of specimen strain of Bacterium entericum is suppressed, and only 6 examples still have the only a few bacteria live; In 80% concentration honey liquor, test organisms does not have 1 example existence, show that the antibacterial and sterilizing function of Mel changes with sweet liquid concentration. low concentration has bacteriostasis, Jilin Province bees Science Insitute Ge Ying (1997) with contain moisture 17%, 22%, 25%, 30%, 35%, 40%, the fresh Mel of variable concentrations carry out bacteriostatic experiment.The fresh Mel bacteriostasis rate of variable concentrations is respectively as a result: the Mel bacteriostasis rate that contains moisture 17% is 94.7%, moisture 2% Mel bacteriostasis rate is that the Mel bacteriostasis rate of 90.3%. moisture 25% is 87.5%, moisture 10% Mel bacteriostasis rate is 81.6%, the antibacterial Fructus Jujubae of moisture 35% Mel is 77.1%, and moisture 40% Mel bacteriostasis rate is 67.7%.Document reports that also Mel is remarkable to treatment burn, wound and skin ulcer effect.1991, U.S. surgeon Subrhmmlyam delivered the paper of topical application Mel treatment burn on Britain's surgical magazine.He makes therapeutic effect relatively to the patient of 104 top layer burns with Mel and silver sulfadiazine. and the result shows: 52 patients treat with Mel, and 91% wound has been sterilized, and other 52 patients treat with silver sulfadiazine, and what wound was sterilized has only 70%; State-run traumatology of Transcaucasia republic of the former Soviet Union and orthopedy institute, with the tissue that is prepared for transplanting. as tissues such as skeleton, muscle, nerves, be placed on the long-time row of protecting in the Mel solution under the room temperature, prove through clinical operation: the healing rate height, effective, also have the characteristics of convenient transportation.Document points out that the antibacterial action of Mel is: 1. the high osmosis of Mel, the main component of Mel is a saccharide, accounts for 79.6% of gross weight.Therefore Mel comes down to a kind of saturated even oversaturated sugar juice, and moisture accounts for the heavy 17%-22% of Mel usually.2. the acidity of Mel, natural honey is tart, pH value is all between 3.2-4.5, and the pH value of most of pathogenic bacteria growth and breedings is many between 7.2-7.4, therefore this acidity of Mel is enough to suppress multiple growth of pathogenic bacteria and breeding, and the tart reason of Mel is to contain certain organic acid such as citric acid, malic acid, tartaric acid, lactic acid, oxalic acid, succinic acid, glutamic acid in the honeybee Mel. the gluconic acid that acetic acid, formic acid, hydroxyl succinic acid, benzoic acid and breakdown of glucose produce etc.Document reports that also Mel is that Apis forms the last saliva brew of nectar mixing, so contains its salivary gland, excretory some enzyme of nectary in the Mel, and what antibacterial action was arranged mainly is lysozyme and glucoseoxidase etc.Its reason comes from the antibiotic factor of nectariferous plant, and Mel is the excretory honeydew of plant flowers, therefore has the certain plants Fungicidal substance.Mainly contain: flavone compound, contain more than 10 kind of flavone compound in the Mel, be the bactericide that derives from nectariferous plant.A large amount of studies confirm that, multiple functions such as that flavone compound has is antibiotic, antiviral, antifungal, inhibition tumor, flavone compound of finding in Mel such as Quercetin, luteolin, apigenin, Fructus rhamni (Rhamnus davurica Pall.) element, pinobanksin, galangin etc. all have antibacterial action, are effective antimicrobial components.In addition, Mel has the volatile ingredient of some Robinia pseudoacacia L. honey, Mel, Semen Castaneae honey, solidago plant nectar and assorted nectar, and these volatile ingredients have the obvious suppression effect to gram negative bacteria such as pneumobacillus, escherichia coli and Candida albicans.
That Mel of the present invention is selected for use is fresh, without the ripe natural honey of heating processed.
So we can see that from product of the present invention prescription is shown an interesting new approach, medicinal ingredient has only Semen Armeniacae Amarum, Alumen (forging), Mel three flavors, and the prescription dosage is less, make suppository, gel or effervescent after, make the medicine focus of going directly from vagina administration.This medicine is not only easy to use, and toxic and side effects is little, and curative effect is very obvious.
The specific embodiment
Embodiment 1:
Prescription: Alumen (forging) 200g, Semen Armeniacae Amarum 130g, Mel 100g, mixed fatty glycerides 7208, lanoline 50g
Preparation method: get Semen Armeniacae Amarum with hot-water soak 10 minutes, remove the peel, drying is ground into coarse powder; Alumen (forging) is dry, be ground into fine powder; After other gets the mixed fatty glycerides heat fused, Semen Armeniacae Amarum powder, Alumen (forging) powder are added mix homogeneously in the mixed fatty glycerides; Other gets the lanoline heat fused, adds Mel, joins after stirring to contain in the amygdalate mixed fatty glycerides, pours into after grinding repeatedly, sieve with colloid mill, freezing shaping, makes 1000 of finished products after sealing.
The clinical total effective rate of suppository that makes with method of the present invention is 86.7%.
Embodiment 2:
Prescription: Alumen (forging) 300g, Semen Armeniacae Amarum 180g, Mel 200g, mixed fatty glycerides 570g, lanoline 50g
Preparation method: get Semen Armeniacae Amarum with hot-water soak 10 minutes, remove the peel, drying is ground into coarse powder; Alumen (forging) is dry, be ground into fine powder; After other gets the mixed fatty glycerides heat fused, Semen Armeniacae Amarum powder, Alumen (forging) powder are added mix homogeneously in the mixed fatty glycerides; Other gets the lanoline heat fused, adds Mel, joins after stirring to contain in the amygdalate mixed fatty glycerides, pours into after grinding repeatedly, sieve with colloid mill, freezing shaping, makes 1000 of finished products after sealing.
The clinical total effective rate of suppository that makes with method of the present invention is 85%.
Embodiment 3
Prescription: Alumen (forging) 250g, Semen Armeniacae Amarum 150g, Mel 150g, mixed fatty glycerides 600g, lanoline 50g
Preparation method: get Semen Armeniacae Amarum with hot-water soak 10 minutes, remove the peel, drying is ground into coarse powder; Alumen (forging) is dry, be ground into fine powder; After other gets the mixed fatty glycerides heat fused, Semen Armeniacae Amarum powder, Alumen (forging) powder are added mix homogeneously in the mixed fatty glycerides; Other gets the lanoline heat fused, adds Mel, joins after stirring to contain in the amygdalate mixed fatty glycerides, pours into after grinding repeatedly, sieve with colloid mill, freezing shaping, makes 1000 of finished products after sealing.
The clinical total effective rate of suppository that makes with method of the present invention is 86.2%.
Embodiment 4:
Prescription: Alumen (forging) 200g, Semen Armeniacae Amarum 130g, Mel 100g, carbomer 90g, glycerol 100g, triethanolamine are an amount of
Preparation method: get Semen Armeniacae Amarum with hot-water soak 10 minutes, remove the peel, drying is ground into coarse powder; Alumen (forging) is dry, be ground into fine powder; Carbomer was steeped 12 hours with an amount of water logging, and heating makes dissolving and makes about 2% aqueous solution 4500ml; Successively Alumen (forging) powder, Semen Armeniacae Amarum powder, glycerol are added in the above-mentioned solution, grind repeatedly, regulate pH value to 6～7 with triethanolamine after the uniform and smooth, packing, make 1000 of finished products after sealing with colloid mill.
The clinical total effective rate of suppository that makes with method of the present invention is 88%.
Embodiment 5:
Prescription: Alumen (forging) 300g, Semen Armeniacae Amarum 180g, Mel 200g, carbomer 90g, glycerol 100g, triethanolamine are an amount of
Preparation method: get Semen Armeniacae Amarum with hot-water soak 10 minutes, remove the peel, drying is ground into coarse powder; Alumen (forging) is dry, be ground into fine powder; Carbomer was steeped 12 hours with an amount of water logging, and heating makes dissolving and makes about 2% aqueous solution 4250ml; Successively Alumen (forging) powder, Semen Armeniacae Amarum powder, glycerol are added in the above-mentioned solution, grind repeatedly, regulate pH value to 6～7 with triethanolamine after the uniform and smooth, packing, make 1000 of finished products after sealing with colloid mill.
The clinical total effective rate of suppository that makes with method of the present invention is 87%.
Embodiment 6:
Prescription: Alumen (forging) 250g, Semen Armeniacae Amarum 150g, Mel 150g, carbomer 90g, glycerol 100g, triethanolamine are an amount of
Preparation method: get Semen Armeniacae Amarum with hot-water soak 10 minutes, remove the peel, drying is ground into coarse powder; Alumen (forging) is dry, be ground into fine powder; Carbomer was steeped 12 hours with an amount of water logging, and heating makes dissolving and makes about 2% aqueous solution 4350ml; Successively Alumen (forging) powder, Semen Armeniacae Amarum powder, glycerol are added in the above-mentioned solution, grind repeatedly, regulate pH value to 6～7 with triethanolamine after the uniform and smooth, packing, make 1000 of finished products after sealing with colloid mill.
The clinical total effective rate of suppository that makes with method of the present invention is 87%.
Embodiment 7:
Prescription: Alumen (forging) 200g, Semen Armeniacae Amarum 130g, Mel 100g, Polyethylene Glycol-4000 500g, Polyethylene Glycol-600150g, citric acid 100g, sodium bicarbonate 120g
Preparation method: get Semen Armeniacae Amarum with hot-water soak 10 minutes, remove the peel, drying is ground into coarse powder; Alumen (forging) is dry, be ground into fine powder; After taking polyethylene glycol-4000 heat fused, Semen Armeniacae Amarum powder, Alumen (forging) powder, citric acid are added in the Polyethylene Glycol and mix in addition, grind repeatedly evenly with colloid mill; Other adds in the Polyethylene Glycol-600 at the learn from else's experience Mel, sodium bicarbonate of processed, merges to after stirring to contain in the amygdalate Polyethylene Glycol, stirs, and pours into after sieving, freezing shaping, makes 1000 of finished products after sealing.
The clinical total effective rate of suppository that makes with method of the present invention is 87.7%.
Embodiment 8:
Prescription: Alumen (forging) 300g, Semen Armeniacae Amarum 180g, Mel 200g, Polyethylene Glycol-4000 550g, Polyethylene Glycol-600250g, citric acid 100g, sodium bicarbonate 120g
Preparation method: get Semen Armeniacae Amarum with hot-water soak 10 minutes, remove the peel, drying is ground into coarse powder; Alumen (forging) is dry, be ground into fine powder; After taking polyethylene glycol-4000 heat fused, Semen Armeniacae Amarum powder, Alumen (forging) powder, citric acid are added in the Polyethylene Glycol and mix in addition, grind repeatedly evenly with colloid mill; Other adds in the Polyethylene Glycol-600 at the learn from else's experience Mel, sodium bicarbonate of processed, merges to after stirring to contain in the amygdalate Polyethylene Glycol, stirs, and pours into after sieving, freezing shaping, makes 1000 of finished products after sealing.
The clinical total effective rate of suppository that makes with method of the present invention is 86.3%.
Embodiment 9:
Prescription: Alumen (forging) 250g, Semen Armeniacae Amarum 150g, Mel 150g, Polyethylene Glycol-4000 530g, Polyethylene Glycol-600200g, citric acid 100g, sodium bicarbonate 120g
Preparation method: get Semen Armeniacae Amarum with hot-water soak 10 minutes, remove the peel, drying is ground into coarse powder; Alumen (forging) is dry, be ground into fine powder; After taking polyethylene glycol-4000 heat fused, Semen Armeniacae Amarum powder, Alumen (forging) powder, citric acid are added in the Polyethylene Glycol and mix in addition, grind repeatedly evenly with colloid mill; Other adds in the Polyethylene Glycol-600 at the learn from else's experience Mel, sodium bicarbonate of processed, merges to after stirring to contain in the amygdalate Polyethylene Glycol, stirs, and pours into after sieving, freezing shaping, makes 1000 of finished products after sealing.
The clinical total effective rate of suppository that makes with method of the present invention is 86.2%.
Embodiment 10:
Prescription: Alumen (forging) 200g, Semen Armeniacae Amarum 130g, Mel 100g, lactose 350g, citric acid 100g, sodium bicarbonate 120g, polyvinylpyrrolidone is an amount of, starch is an amount of, magnesium stearate is an amount of, dehydrated alcohol is an amount of
Preparation method: get Semen Armeniacae Amarum with hot-water soak 10 minutes, remove the peel, drying is ground into fine powder; Alumen (forging) is dry, be ground into fine powder; Other gets Mel, lactose adds above-mentioned Semen Armeniacae Amarum powder, Alumen (forging) powder mixing and stirring, and the starch slurry with 2～5% is granulated, oven dry; Granule adds sodium bicarbonate, citric acid stirs, and 2～5% polyvinylpyrrolidone alcoholic solution carry out the secondary granulation, the oven dry back adds an amount of magnesium stearate tabletting with adding in the back, make 1000 of finished products.
The clinical total effective rate of suppository that makes with method of the present invention is 85.2%.
Embodiment 11:
Prescription: Alumen (forging) 300g, Semen Armeniacae Amarum 180g, Mel 200g, lactose 300g, citric acid 100g, sodium bicarbonate 120g, polyvinylpyrrolidone is an amount of, starch is an amount of, magnesium stearate is an amount of, dehydrated alcohol is an amount of
Preparation method: get Semen Armeniacae Amarum with hot-water soak 10 minutes, remove the peel, drying is ground into fine powder; Alumen (forging) is dry, be ground into fine powder; Other gets Mel, lactose adds above-mentioned Semen Armeniacae Amarum powder, Alumen (forging) powder mixing and stirring, and the starch slurry with 2～5% is granulated, oven dry; Granule adds sodium bicarbonate, citric acid stirs, and 2～5% polyvinylpyrrolidone alcoholic solution carry out the secondary granulation, the oven dry back adds an amount of magnesium stearate tabletting with adding in the back, make 1000 of finished products.
The clinical total effective rate of suppository that makes with method of the present invention is 86.8%.
Embodiment 12:
Prescription: Alumen (forging) 250g, Semen Armeniacae Amarum 150g, Mel 150g, lactose 330g, citric acid 100g, sodium bicarbonate 120g, polyvinylpyrrolidone is an amount of, starch is an amount of, magnesium stearate is an amount of, dehydrated alcohol is an amount of
Preparation method: get Semen Armeniacae Amarum with hot-water soak 10 minutes, remove the peel, drying is ground into fine powder; Alumen (forging) is dry, be ground into fine powder; Other gets Mel, lactose adds above-mentioned Semen Armeniacae Amarum powder, Alumen (forging) powder mixing and stirring, and the starch slurry with 2～5% is granulated, oven dry; Granule adds sodium bicarbonate, citric acid stirs, and 2～5% polyvinylpyrrolidone alcoholic solution carry out the secondary granulation, the oven dry back adds an amount of magnesium stearate tabletting with adding in the back, make 1000 of finished products.
The clinical total effective rate of suppository that makes with method of the present invention is 84.6%.
Pharmacology, pharmacodynamics and clinical trial
The test of pesticide effectiveness result of this product is as follows:
1, putrefaction-removing granulation-promoting effect test shows: this product has tangible promotion healing effect to rats after burn and through the wound surface of the animal model of charrin's disease.
Prompting: this product has good putrefaction-removing granulation-promoting effect, provides certain foundation for treating the leukorrhagia that cervicitis and cervical erosion causes clinically.
2, in-vitro antibacterial, anti-trichomonas vaginitis effect test show: this product is 1: 200 to the minimal inhibitory concentration of escherichia coli, staphylococcus aureus, bacillus pyocyaneus, group B streptococcus etc., to the oidiomycetic minimal inhibitory concentration of white is 1: 400, is 1: 100 to gonococcal minimal inhibitory concentration; External to trichomonas vaginitis kill concentration and the time is: be 10 minute at 1: 25, and be 20 minute at 1: 50, and be 30 minute at 1: 100, and be 60 minute at 1: 200, and be 24 hour at 1: 400.
Prompting: this product has stronger antibiotic, anti-trichomonas vaginitis effect, provides certain foundation for treating gynecological inflammation clinically.
3, antiinflammatory test shows: this product can obviously suppress mice auricle swelling due to the Oleum Tiglii and the rat paw edema due to the chondrus ocellatus Holmes, can also suppress the hypertrophy of mice cotton balls granulation tissue.
Prompting: this product has stronger antiinflammatory action, provides certain foundation for treating gynecological inflammation clinically.
4, itching-relieving action test shows: the be significantly improved effect of Cavia porcellus itch-threshold of this product.
Prompting: this product has tangible itching-relieving action, provides certain foundation for treating the Pruritus that gynecological inflammation causes clinically.
The clinical test results of this product is as follows:
Curative effect judging standard
1, recovery from illness: leukorrhagia amount, color, matter, abnormal smells from the patient transfer normal condition to, and General Symptoms takes a turn for the better, and the vagina local symptom disappears; The laboratory examination vagina cleanness degree is I °, and it is normal that pH value recovers, and leukocyte or pyocyte become feminine gender.
2, produce effects: the leukorrhagia amount becomes the I level by III level or II level, and color, matter, abnormal smells from the patient recover normal.General Symptoms takes a turn for the better, local symptom is clearly better; The laboratory examination vagina cleanness degree becomes I ° by III ° or II °.PH value 5-6, leukocyte or pyocyte become feminine gender.
3, effective: leukorrhagia amount, color, matter, abnormal smells from the patient are clearly better; Whole body and local sx; The laboratory examination vagina cleanness degree becomes II ° by III °, and leukocyte or pyocyte reduce.
4, invalid: leukorrhagia amount, color, matter, abnormal smells from the patient do not have improvement; Whole body and local symptom no change; Laboratory examination vagina cleanness degree and pH value no change, leukocyte or pyocyte no change.
This research is carried out clinical observation on the therapeutic effect to the patient that 580 examples suffer from profuse leukorrhea, cervical erosion disease altogether, wherein 500 examples are organized in treatment, matched group 80 examples, it is 28.3% that average cure rate is organized in treatment, obvious effective rate is 31.7%, effective percentage is 26.7%, and recovery from illness and obvious effective rate are 60%, and total effective rate is 86.7%; The matched group cure rate is 18.3%, and obvious effective rate is 20%, and effective percentage is 35%, and recovery from illness and obvious effective rate are 38.3%, and total effective rate is 73.3%.
Prompting: this product treatment profuse leukorrhea, cervical erosion have clinical efficacy preferably, and its curative effect is better than contrast medicine commonly used clinically at present.
Claims (5)
1. vagina Chinese medicine preparation for the treatment of women's profuse leukorrhea, cervical erosion, it is characterized in that: this Chinese medicine preparation is to make with the raw material of Chinese medicine of following weight fraction:
From vitriol 0.15～0.30 Semen Armeniacae Amarum 0.10～0.20 Mel 0.10～0.20
Described Alumen after vitriol is calcine;
Above-mentioned raw material of Chinese medicine is made suppository, gel, effervescent tablet or type of effervescent suppository preparation respectively after adding adjuvant.
2. the vagina Chinese medicine preparation of treatment according to claim 1 women profuse leukorrhea, cervical erosion, it is characterized in that: the preparation method of suppository is as follows: with the Alumen drying, pulverize, sieve; Semen Armeniacae Amarum is removed the peel, pulverizes, sieved; Adding Semen Armeniacae Amarum powder and Alumen powder after the suppository base heat fused are stirred, other adds Mel after getting part suppository base heat fused, and add other adjuvants as required, then above two kinds of medicinal liquids are mixed, grind repeatedly to make to seal behind its uniform and smooth, perfusion, the cooling forming with colloid mill and promptly get suppository;
Described substrate is fatty glyceride, lanoline, cocoa butter.
3. the vagina Chinese medicine preparation of treatment according to claim 1 women profuse leukorrhea, cervical erosion, it is characterized in that: the preparation method of gel is as follows: with the Alumen drying, pulverize, sieve; With the Semen Armeniacae Amarum peeling, pulverize, sieve, the gel substrate heating is made the aqueous solution that dissolves and make about 1-5%; Successively Alumen powder, Semen Armeniacae Amarum powder, Mel, glycerol are added in the above-mentioned solution, and add other adjuvants as required, grind repeatedly, regulate pH value to 6～7 with alkali after the uniform and smooth, packing, make gel after sealing with colloid mill;
Described gel substrate is carbomer, cellulose derivative, glycerol, gelatin or propylene glycol, and the alkali of regulating pH value adopts sodium hydroxide, sodium bicarbonate or triethanolamine.
4. the vagina Chinese medicine preparation of treatment according to claim 1 women profuse leukorrhea, cervical erosion, it is characterized in that: the preparation method of type of effervescent suppository is as follows: with the Alumen drying, pulverize, sieve; Semen Armeniacae Amarum is removed the peel, pulverizes, sieved; Semen Armeniacae Amarum powder, Alumen powder and organic acid will be added after the suppository base heat fused, stirring is ground repeatedly with colloid mill and is made its uniform and smooth, other gets Mel, the sodium bicarbonate that adds after the part suppository base heat fused through processed, then with above two kinds of medicinal liquid mix homogeneously, perfusion is sealed behind the cooling forming and is promptly got suppository;
Described substrate can be used water-soluble basees such as Polyethylene Glycol, polyoxyethylene stearate (40) fat; Other adjuvant can be regulators such as ethanol, propylene glycol, Polysorbate, also can add antioxidant and organic acid.
5. the vagina Chinese medicine preparation of treatment according to claim 1 women profuse leukorrhea, cervical erosion is characterized in that the preparation method of effervescent tablet is as follows: with the Alumen drying, pulverize, sieve; Semen Armeniacae Amarum is removed the peel, pulverizes, sieved; Add suitable adjuvant mix with Alumen powder, Semen Armeniacae Amarum powder, Mel, moistening, granulate, oven dry, and then add that foaming agent and suitable adjuvant carry out that secondary is granulated, oven dry, add tabletting behind the suitable adjuvant again, promptly get effervescent tablet;
Described adjuvant is dehydrated alcohol, lactose, polyvinylpyrrolidone, starch, hard fatty acids magnesium; Used foaming agent is organic acid and sodium bicarbonate such as citric acid, tartaric acid.
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| CNB200510036624XA CN100364576C (en) | 2005-08-22 | 2005-08-22 | Vagina applied Chinese medicinal preparation for treating profuse leukorrhea and cervical erosion and preparation method thereof |
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| CNB200510036624XA CN100364576C (en) | 2005-08-22 | 2005-08-22 | Vagina applied Chinese medicinal preparation for treating profuse leukorrhea and cervical erosion and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1116949A (en) * | 1995-04-11 | 1996-02-21 | 孔繁营 | Chinese herb medicine for external use of gynecopathy |
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2005
- 2005-08-22 CN CNB200510036624XA patent/CN100364576C/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1116949A (en) * | 1995-04-11 | 1996-02-21 | 孔繁营 | Chinese herb medicine for external use of gynecopathy |
Non-Patent Citations (1)
| Title |
|---|
| 中药治疗***119例. 赵景明，孟渝梅.山西中医，第9卷第2期. 1993 * |
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