CN100358497C - 金莲花滴丸及其制备方法 - Google Patents
金莲花滴丸及其制备方法 Download PDFInfo
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- CN100358497C CN100358497C CNB200510004949XA CN200510004949A CN100358497C CN 100358497 C CN100358497 C CN 100358497C CN B200510004949X A CNB200510004949X A CN B200510004949XA CN 200510004949 A CN200510004949 A CN 200510004949A CN 100358497 C CN100358497 C CN 100358497C
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- polyethylene glycol
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- 239000006187 pill Substances 0.000 title claims abstract description 56
- 238000000034 method Methods 0.000 title description 20
- 240000004825 Tropaeolum peregrinum Species 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 106
- 241001530121 Trollius Species 0.000 claims abstract description 28
- 239000000203 mixture Substances 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000000284 extract Substances 0.000 claims description 82
- 239000002202 Polyethylene glycol Substances 0.000 claims description 78
- 229920001223 polyethylene glycol Polymers 0.000 claims description 78
- 239000000758 substrate Substances 0.000 claims description 43
- -1 polyoxyethylene stearate Polymers 0.000 claims description 33
- 229920002472 Starch Polymers 0.000 claims description 32
- 235000019698 starch Nutrition 0.000 claims description 32
- 239000008107 starch Substances 0.000 claims description 32
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 29
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 29
- 239000011734 sodium Substances 0.000 claims description 29
- 229910052708 sodium Inorganic materials 0.000 claims description 29
- 150000002148 esters Chemical class 0.000 claims description 28
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000004353 Polyethylene glycol 8000 Substances 0.000 claims description 7
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- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
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- IQXJCCZJOIKIAD-UHFFFAOYSA-N 1-(2-methoxyethoxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOCCOC IQXJCCZJOIKIAD-UHFFFAOYSA-N 0.000 claims 1
- 229950009789 cetomacrogol 1000 Drugs 0.000 claims 1
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims 1
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- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 27
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 27
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- 239000001828 Gelatine Substances 0.000 description 8
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 8
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 8
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 8
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 8
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 8
- 239000008117 stearic acid Substances 0.000 description 8
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- 239000000126 substance Substances 0.000 description 2
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- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 102000000340 Glucosyltransferases Human genes 0.000 description 1
- 108010055629 Glucosyltransferases Proteins 0.000 description 1
- 241001640034 Heteropterys Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
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- 239000013078 crystal Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 125000002791 glucosyl group Chemical class C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
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- 239000004531 microgranule Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
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- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
Description
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
聚乙二醇<sub>2000</sub> | 50.0 | 64 | <30 | >10 | + |
聚乙二醇<sub>4000</sub> | 50.0 | 76 | <30 | >10 | + |
聚乙二醇<sub>6000</sub> | 50.0 | 80 | <30 | >10 | ++ |
聚乙二醇<sub>8000</sub> | 50.0 | 83 | <30 | >10 | ++ |
聚乙二醇<sub>10000</sub> | 50.0 | 85 | <30 | >10 | ++ |
聚乙二醇<sub>20000</sub> | 50.0 | 86 | <30 | >10 | ++ |
硬脂酸聚烃氧40酯 | 50.0 | 74 | <30 | >10 | ++ |
倍他环糊精 | 50.0 | 72 | <30 | >10 | + |
泊洛沙姆 | 50.0 | 73 | <30 | >10 | ++ |
羧甲基淀粉钠 | 50.0 | 71 | <30 | >10 | + |
十二烷基硫酸钠 | 50.0 | 69 | >30 | >10 | ++ |
硬脂酸 | 50.0 | 58 | >30 | >10 | ++ |
硬脂酸钠 | 50.0 | 54 | >30 | >10 | ++ |
甘油明胶 | 50.0 | 56 | >30 | >10 | + |
虫胶 | 50.0 | 53 | >30 | >10 | + |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
聚乙二醇<sub>2000</sub> | 25.0 | 79 | <30 | >10 | ++ |
聚乙二醇<sub>4000</sub> | 25.0 | 86 | <30 | <10 | +++ |
聚乙二醇<sub>6000</sub> | 25.0 | 91 | <30 | <10 | +++ |
聚乙二醇<sub>8000</sub> | 25.0 | 91 | <30 | <10 | +++ |
聚乙二醇<sub>10000</sub> | 25.0 | 92 | <30 | <10 | +++ |
聚乙二醇<sub>20000</sub> | 25.0 | 92 | <30 | <10 | +++ |
硬脂酸聚烃氧40酯 | 25.0 | 93 | <30 | <10 | ++ |
倍他环糊精 | 25.0 | 83 | <30 | >10 | ++ |
泊洛沙姆 | 25.0 | 91 | <30 | <10 | +++ |
羧甲基淀粉钠 | 25.0 | 86 | <30 | <10 | +++ |
十二烷基硫酸钠 | 25.0 | 77 | <30 | >10 | ++ |
硬脂酸 | 25.0 | 73 | >30 | >10 | +++ |
硬脂酸钠 | 25.0 | 71 | >30 | >10 | +++ |
甘油明胶 | 25.0 | 70 | >30 | >10 | +++ |
虫胶 | 25.0 | 70 | >30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
聚乙二醇<sub>2000</sub> | 10.0 | 84 | <30 | >10 | ++ |
聚乙二醇<sub>4000</sub> | 10.0 | 88 | <30 | <10 | +++ |
聚乙二醇<sub>6000</sub> | 10.0 | 93 | <30 | <10 | +++ |
聚乙二醇<sub>8000</sub> | 10.0 | 93 | <30 | <10 | +++ |
聚乙二醇<sub>10000</sub> | 10.0 | 92 | <30 | <10 | +++ |
聚乙二醇<sub>20000</sub> | 10.0 | 94 | <30 | <10 | +++ |
硬脂酸聚烃氧40酯 | 10.0 | 89 | <30 | <10 | ++ |
倍他环糊精 | 10.0 | 87 | <30 | <10 | ++ |
泊洛沙姆 | 10.0 | 92 | <30 | <10 | +++ |
羧甲基淀粉钠 | 10.0 | 82 | <30 | >10 | +++ |
十二烷基硫酸钠 | 10.0 | 81 | <30 | >10 | +++ |
硬脂酸 | 10.0 | 79 | >30 | >10 | +++ |
硬脂酸钠 | 10.0 | 80 | >30 | >10 | +++ |
甘油明胶 | 10.0 | 76 | >30 | >10 | +++ |
虫胶 | 10.0 | 78 | >30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶1 | 50 | 84 | <30 | >10 | ++ |
泊洛沙姆∶聚乙二醇=1∶1 | 50 | 82 | <30 | >10 | ++ |
羧甲基淀粉钠∶聚乙二醇=1∶1 | 50 | 79 | <30 | >10 | ++ |
倍他环糊精∶聚乙二醇=1∶1 | 50 | 72 | <30 | >10 | + |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶1 | 25 | 88 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶1 | 25 | 89 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶1 | 25 | 86 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶1 | 25 | 82 | <30 | >10 | ++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶1 | 10 | 88 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶1 | 10 | 86 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶1 | 10 | 83 | <30 | >10 | +++ |
倍他环糊精∶聚乙二醇=1∶1 | 10 | 80 | <30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶5 | 50 | 91 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶5 | 50 | 90 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶5 | 50 | 90 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶5 | 50 | 86 | <30 | <10 | ++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶5 | 25 | 93 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶5 | 25 | 93 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶5 | 25 | 91 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶5 | 25 | 88 | <30 | <10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶5 | 10 | 93 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶5 | 10 | 92 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶5 | 10 | 92 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶5 | 10 | 89 | <30 | <10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶10 | 50 | 92 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶10 | 50 | 91 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶10 | 50 | 87 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶10 | 50 | 84 | <30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶10 | 25 | 92 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶10 | 25 | 92 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶10 | 25 | 89 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶10 | 25 | 87 | <30 | <10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶10 | 10 | 91 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶10 | 10 | 92 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶10 | 10 | 91 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶10 | 10 | 91 | <30 | <10 | +++ |
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNB200510004949XA CN100358497C (zh) | 2005-01-31 | 2005-01-31 | 金莲花滴丸及其制备方法 |
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