CL2023000741A1 - Anticuerpo anti-nectina-4, conjugado que lo incluye y aplicación de los mismos. - Google Patents

Anticuerpo anti-nectina-4, conjugado que lo incluye y aplicación de los mismos.

Info

Publication number
CL2023000741A1
CL2023000741A1 CL2023000741A CL2023000741A CL2023000741A1 CL 2023000741 A1 CL2023000741 A1 CL 2023000741A1 CL 2023000741 A CL2023000741 A CL 2023000741A CL 2023000741 A CL2023000741 A CL 2023000741A CL 2023000741 A1 CL2023000741 A1 CL 2023000741A1
Authority
CL
Chile
Prior art keywords
antibody
nectin
conjugate
application
medicament
Prior art date
Application number
CL2023000741A
Other languages
English (en)
Inventor
Liang Xiao
Tongtong Xue
Jingyi Wang
Cheng Wang
Dengnian Liu
Fen Li
Junyou Ge
Le Liu
Qi Ren
Original Assignee
Sichuan Kelun Biotech Biopharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Kelun Biotech Biopharmaceutical Co Ltd filed Critical Sichuan Kelun Biotech Biopharmaceutical Co Ltd
Publication of CL2023000741A1 publication Critical patent/CL2023000741A1/es

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Abstract

Se proporciona un anticuerpo anti-nectina-4 o un fragmento de unión a antígeno del mismo, un conjugado de anticuerpo que comprende el mismo, y el uso del mismo en la fabricación de un medicamento, particularmente en la fabricación de un medicamento para tratar y/o prevenir el cáncer.
CL2023000741A 2020-09-16 2023-03-15 Anticuerpo anti-nectina-4, conjugado que lo incluye y aplicación de los mismos. CL2023000741A1 (es)

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WO2023180490A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing nectin-4
CN117982672A (zh) * 2022-07-14 2024-05-07 百奥泰生物制药股份有限公司 抗Nectin-4抗体药物偶联物及应用
EP4310101A1 (en) * 2022-07-22 2024-01-24 Emergence Therapeutics AG Novel anti-nectin-4 antibodies and antibody-drug conjugates

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WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
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CN110392697A (zh) * 2017-03-02 2019-10-29 国家医疗保健研究所 对nectin-4具有特异性的抗体及其用途
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US11970506B2 (en) 2017-12-15 2024-04-30 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Bioactive molecule conjugate, preparation method and use thereof
CA3097679A1 (en) 2018-05-09 2019-11-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Antibodies specific to human nectin4
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