CL2022002490A1 - Biaryl derivatives as inhibitors of yap/taz-tead protein-protein interaction - Google Patents

Biaryl derivatives as inhibitors of yap/taz-tead protein-protein interaction

Info

Publication number
CL2022002490A1
CL2022002490A1 CL2022002490A CL2022002490A CL2022002490A1 CL 2022002490 A1 CL2022002490 A1 CL 2022002490A1 CL 2022002490 A CL2022002490 A CL 2022002490A CL 2022002490 A CL2022002490 A CL 2022002490A CL 2022002490 A1 CL2022002490 A1 CL 2022002490A1
Authority
CL
Chile
Prior art keywords
protein
yap
taz
inhibitors
tead
Prior art date
Application number
CL2022002490A
Other languages
Spanish (es)
Inventor
Liliane Jeanne Lorthiois Edwige
Bordas Vincent
Brocklehurst Cara
Chene Patrick
FEI Zhongbo
Furet Pascal
Guagnano Vito
Imbach-Weese Patricia
Kallen Joerg
Le Douget Mickael
Li Jialiang
Li Wei
Mckenna Joseph
Salem Bahaa
Schmelzle Tobias
Sellner Holger
Soldermann Nicolas
Voegtle Markus
Wartmann Markus
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2022002490A1 publication Critical patent/CL2022002490A1/en

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona un compuesto de la fórmula (I) o una sal farmacéuticamente aceptable del mismo; un método de elaboración de dicho compuesto, y sus usos terapéuticos. La presente invención proporciona además una combinación de agentes farmacológicamente activos y una composición farmacéutica que comprende dicho compuesto.The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method of making said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

CL2022002490A 2020-03-16 2022-09-12 Biaryl derivatives as inhibitors of yap/taz-tead protein-protein interaction CL2022002490A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16034656 2020-03-16
CN2021075550 2021-02-05

Publications (1)

Publication Number Publication Date
CL2022002490A1 true CL2022002490A1 (en) 2023-05-05

Family

ID=86558129

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2022002490A CL2022002490A1 (en) 2020-03-16 2022-09-12 Biaryl derivatives as inhibitors of yap/taz-tead protein-protein interaction

Country Status (1)

Country Link
CL (1) CL2022002490A1 (en)

Similar Documents

Publication Publication Date Title
DOP2022000183A (en) BIARYL DERIVATIVES AS INHIBITORS OF YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION
DOP2022000124A (en) PYRAZOLIL DERIVATIVES USEFUL AS ANTICANCER AGENTS
CL2021001292A1 (en) Combination therapy including a krasg12c inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers
SV2011004077A (en) AMINOBUTIRIC DERIVATIVES REPLACED AS NEPRILISINE INHIBITORS
NI201600058A (en) RING-FUSED BICYCLIC PYRIDYL-DERIVED COMPOUNDS AS FGFR4 INHIBITORS
CO6470847A2 (en) AMINO-PROPIONIC DERIVATIVES REPLACED AS NEPRILISINE INHIBITORS
CO2021005532A2 (en) Quinoline derivatives as inhibitors of integrin alpha4beta7
CO2020004669A2 (en) Benzimidazole derivatives and their uses
CO2021002976A2 (en) 5- to 7-membered heterocyclic amides as jak inhibitors
BR112017016817A2 (en) heterocyclic derivatives formulated as fgfr4 inhibitors
CU20160166A7 (en) COMPOUNDS DERIVED FROM N- (1,5-DIMETIL-3-OXO-2,3-DIHIDRO-1H-PIRAZOL-4-IL) -4-METHYL-5-ISOXAZOL-3-CARBOXAMIDE AS SELECTIVE INHIBITORS OF SMURF-1
UY39150A (en) PYRROLOPYRIMIDINAMINES AS INHIBITORS OF THE COMPLEMENT SYSTEM
DOP2019000299A (en) 5,6-FUSED BICYCLIC COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
CO2023002940A2 (en) Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof
DOP2020000088A (en) PYRIDINONE DERIVATIVES AND THEIR USE AS SELECTIVE ALK – 2 INHIBITORS.
CL2022002490A1 (en) Biaryl derivatives as inhibitors of yap/taz-tead protein-protein interaction
CL2022002817A1 (en) Human immunodeficiency virus replication inhibitors
AR124982A1 (en) MACROCYCLES AND THEIR USES
UY39722A (en) New derivatives of heteroaryl aminopropanol
ECSP23073082A (en) Novel cyclopenta[c]pyrrole negative allosteric modulators of NR2B
AR125934A1 (en) MACROCYCLIC COMPOUNDS TO TREAT DISEASES
AR125479A1 (en) IL4I1 INHIBITORS AND METHODS OF USE
EA201990763A1 (en) DOPAMINE-B-HYDROXYLASE INHIBITORS penetrating through the blood-brain barrier