CL2020003371A1 - Péptidos restringidos por a*03 para el uso en la inmunoterapia contra el cáncer y métodos relacionados - Google Patents

Péptidos restringidos por a*03 para el uso en la inmunoterapia contra el cáncer y métodos relacionados

Info

Publication number
CL2020003371A1
CL2020003371A1 CL2020003371A CL2020003371A CL2020003371A1 CL 2020003371 A1 CL2020003371 A1 CL 2020003371A1 CL 2020003371 A CL2020003371 A CL 2020003371A CL 2020003371 A CL2020003371 A CL 2020003371A CL 2020003371 A1 CL2020003371 A1 CL 2020003371A1
Authority
CL
Chile
Prior art keywords
peptides
relates
present
lymphocytes
tumor
Prior art date
Application number
CL2020003371A
Other languages
English (en)
Inventor
Toni Weinschenk
Jens Fritsche
Colette Song
Harpreet Singh
Oliver Schoor
Daniel Kowalewski
Heiko Schuster
Linus Backert
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102018115865.3A external-priority patent/DE102018115865A1/de
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of CL2020003371A1 publication Critical patent/CL2020003371A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a péptidos, proteínas, ácidos nucleicos y células destinados a la utilización en métodos inmunoterapéuticos. En particular, la presente invención se refiere a la inmunoterapia contra el cáncer. La presente invención se refiere asimismo a epítopos peptídicos para linfocitos T asociados a tumores, solos o en combinación con otros péptidos asociados a tumores que, por ejemplo, pueden servir como principios activos farmacéuticos en composiciones vacunales destinadas a estimular respuestas inmunitarias antitumorales, o a estimular ex vivo linfocitos T que después serán transferidos a los pacientes. Los péptidos unidos a moléculas del complejo mayor de histocompatibilidad (MHC), o los péptidos como tales, también pueden ser dianas de anticuerpos, de receptores de linfocitos T solubles, y de otras moléculas de unión.
CL2020003371A 2018-06-29 2020-12-23 Péptidos restringidos por a*03 para el uso en la inmunoterapia contra el cáncer y métodos relacionados CL2020003371A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862692348P 2018-06-29 2018-06-29
DE102018115865.3A DE102018115865A1 (de) 2018-06-29 2018-06-29 A*03-restringierte Peptide zur Verwendung in der Immuntherapie gegen Krebs und verwandte Verfahren
DE102018116584 2018-07-09
US16/030,725 US10925947B2 (en) 2018-06-29 2018-07-09 A*03 restricted peptides for use in immunotherapy against cancers and related methods

Publications (1)

Publication Number Publication Date
CL2020003371A1 true CL2020003371A1 (es) 2021-05-07

Family

ID=67070807

Family Applications (4)

Application Number Title Priority Date Filing Date
CL2020003371A CL2020003371A1 (es) 2018-06-29 2020-12-23 Péptidos restringidos por a*03 para el uso en la inmunoterapia contra el cáncer y métodos relacionados
CL2022003382A CL2022003382A1 (es) 2018-06-29 2022-11-30 Péptidos restringidos por a*03, uso en inmunoterapia contra cáncer y métodos relacionados (solicitud divisional de 202003371)
CL2022003380A CL2022003380A1 (es) 2018-06-29 2022-11-30 Péptidos restringidos por a*03, uso en inmunoterapia contra cáncer y métodos relacionados (solicitud divisional de 202003371)
CL2022003381A CL2022003381A1 (es) 2018-06-29 2022-11-30 Péptidos restringidos por a*03, uso en inmunoterapia contra cáncer y métodos relacionados (solicitud divisional de 202003371)

Family Applications After (3)

Application Number Title Priority Date Filing Date
CL2022003382A CL2022003382A1 (es) 2018-06-29 2022-11-30 Péptidos restringidos por a*03, uso en inmunoterapia contra cáncer y métodos relacionados (solicitud divisional de 202003371)
CL2022003380A CL2022003380A1 (es) 2018-06-29 2022-11-30 Péptidos restringidos por a*03, uso en inmunoterapia contra cáncer y métodos relacionados (solicitud divisional de 202003371)
CL2022003381A CL2022003381A1 (es) 2018-06-29 2022-11-30 Péptidos restringidos por a*03, uso en inmunoterapia contra cáncer y métodos relacionados (solicitud divisional de 202003371)

Country Status (19)

Country Link
US (12) US10925947B2 (es)
EP (1) EP3813873A1 (es)
JP (1) JP2021528046A (es)
KR (1) KR20210025534A (es)
CN (2) CN112399853A (es)
AU (1) AU2019294731A1 (es)
BR (1) BR112020022250A2 (es)
CA (1) CA3097698A1 (es)
CL (4) CL2020003371A1 (es)
CO (1) CO2020013659A2 (es)
CR (1) CR20200632A (es)
IL (1) IL279843A (es)
MA (1) MA53004A (es)
MX (1) MX2020012257A (es)
PE (1) PE20211499A1 (es)
PH (1) PH12020552013A1 (es)
SG (1) SG11202009659XA (es)
TW (1) TW202019462A (es)
WO (1) WO2020002063A1 (es)

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US11872270B2 (en) 2024-01-16
PH12020552013A1 (en) 2021-06-28
US20210330771A1 (en) 2021-10-28
US20210128707A1 (en) 2021-05-06
CR20200632A (es) 2021-01-25
CN113444148A (zh) 2021-09-28
US11833193B2 (en) 2023-12-05
US20230226162A1 (en) 2023-07-20
US10946081B2 (en) 2021-03-16
TW202019462A (zh) 2020-06-01
CL2022003382A1 (es) 2023-06-02
US11058755B2 (en) 2021-07-13
US20210138052A1 (en) 2021-05-13
US11246917B2 (en) 2022-02-15
CA3097698A1 (en) 2020-01-02
KR20210025534A (ko) 2021-03-09
MA53004A (fr) 2021-05-26
US11554164B2 (en) 2023-01-17
US20210128708A1 (en) 2021-05-06
US20220362364A1 (en) 2022-11-17
CO2020013659A2 (es) 2020-11-10
US20210330772A1 (en) 2021-10-28
MX2020012257A (es) 2021-03-25
CL2022003380A1 (es) 2023-06-02
CL2022003381A1 (es) 2023-06-02
US20200289632A1 (en) 2020-09-17
JP2021528046A (ja) 2021-10-21
CN112399853A (zh) 2021-02-23
US20200323970A1 (en) 2020-10-15
EP3813873A1 (en) 2021-05-05
US10869917B2 (en) 2020-12-22
US10925947B2 (en) 2021-02-23
US20220370583A1 (en) 2022-11-24
US10828357B2 (en) 2020-11-10
IL279843A (en) 2021-03-01
US11576955B2 (en) 2023-02-14
US20200000897A1 (en) 2020-01-02
PE20211499A1 (es) 2021-08-11
WO2020002063A1 (en) 2020-01-02
AU2019294731A1 (en) 2020-10-29
SG11202009659XA (en) 2021-01-28
BR112020022250A2 (pt) 2021-02-23
US20200000895A1 (en) 2020-01-02

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