CL2020001020A1 - Benzimidazole derivatives and their uses. - Google Patents
Benzimidazole derivatives and their uses.Info
- Publication number
- CL2020001020A1 CL2020001020A1 CL2020001020A CL2020001020A CL2020001020A1 CL 2020001020 A1 CL2020001020 A1 CL 2020001020A1 CL 2020001020 A CL2020001020 A CL 2020001020A CL 2020001020 A CL2020001020 A CL 2020001020A CL 2020001020 A1 CL2020001020 A1 CL 2020001020A1
- Authority
- CL
- Chile
- Prior art keywords
- benzimidazole derivatives
- compound
- present
- trpc6
- transitory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
LA PRESENTE INVENCIÓN HACE REFERENCIA A INHIBIDORES DE LA ACTIVIDAD DE PROTEÍNAS DE CANAL DE POTENCIAL RECEPTOR TRANSITORIO 6 (TRPC6). LA PRESENTE INVENCIÓN PROVEE UN COMPUESTO DE FÓRMULA (I) O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DE ESTE, COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN UN COMPUESTO DE LA INVENCIÓN, UN MÉTODO PARA FABRICAR COMPUESTOS DE LA INVENCIÓN Y USOS TERAPÉUTICOS DE ESTOS.THE PRESENT INVENTION MAKES REFERENCE TO INHIBITORS OF THE ACTIVITY OF CHANNEL PROTEINS OF TRANSITORY RECEPTOR POTENTIAL 6 (TRPC6). THE PRESENT INVENTION PROVIDES A COMPOUND OF FORMULA (I) OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE A COMPOUND OF THE INVENTION, A METHOD FOR MANUFACTURING COMPOUNDS OF THE INVENTION AND THERAPEUTIC USES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762574465P | 2017-10-19 | 2017-10-19 | |
US201862671090P | 2018-05-14 | 2018-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020001020A1 true CL2020001020A1 (en) | 2020-09-21 |
Family
ID=66173507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020001020A CL2020001020A1 (en) | 2017-10-19 | 2020-04-16 | Benzimidazole derivatives and their uses. |
Country Status (19)
Country | Link |
---|---|
US (1) | US11332459B2 (en) |
EP (1) | EP3697410A4 (en) |
JP (1) | JP7450534B2 (en) |
KR (1) | KR20200074965A (en) |
CN (1) | CN111417394B (en) |
AU (1) | AU2018351059B2 (en) |
BR (1) | BR112020007589A8 (en) |
CA (1) | CA3079081A1 (en) |
CL (1) | CL2020001020A1 (en) |
CO (1) | CO2020004669A2 (en) |
IL (1) | IL273839B (en) |
MA (1) | MA50413A (en) |
MX (1) | MX2020003993A (en) |
PH (1) | PH12020550265A1 (en) |
SA (1) | SA520411787B1 (en) |
SG (1) | SG11202003502VA (en) |
TW (1) | TWI816704B (en) |
UY (1) | UY37941A (en) |
WO (1) | WO2019079578A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3793565T3 (en) | 2018-05-14 | 2022-05-02 | Gilead Sciences, Inc. | Mcl-1 inhibitors |
EP3952866A4 (en) * | 2019-04-11 | 2023-01-25 | Teijin Pharma Limited | Benzimidazole derivatives and their uses |
TWI778443B (en) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1 inhibitors |
CN114787139A (en) | 2019-11-26 | 2022-07-22 | 吉利德科学公司 | Processes and intermediates for preparing MCL1 inhibitors |
AR121846A1 (en) | 2020-04-16 | 2022-07-13 | Teijin Pharma Ltd | DERIVATIVE OF ARYL OR HETEROARYL |
JPWO2023276828A1 (en) * | 2021-06-29 | 2023-01-05 |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2618435B1 (en) | 1987-07-23 | 1989-10-27 | Synthelabo | BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
US5670501A (en) | 1994-09-01 | 1997-09-23 | Discovery Therapeutics, Inc. | N-substituted 9-alkyladenines |
NZ524618A (en) * | 2000-08-10 | 2004-08-27 | Mitsubishi Pharma Corp | Proline derivatives and use thereof as drugs |
DE60216627T2 (en) | 2001-10-15 | 2007-09-20 | Janssen Pharmaceutica N.V. | NEW SUBSTITUTED 4-PHENYL-4-IAH-IMIDAZO-2-YLÜ-PIPERIDINE DERIVATIVES AND THEIR USE AS SELECTIVE DELTA OPIOID AGONISTS |
JP4418676B2 (en) | 2001-10-15 | 2010-02-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Substituted 4-phenyl-4- (1H-imidazol-2-yl) -piperidine derivatives for reducing ischemic damage |
DE60329513D1 (en) | 2002-07-30 | 2009-11-12 | Banyu Pharma Co Ltd | ANTAGONIST OF MELANINE CONCENTRATING HORMONE RECEPTOR, CONTAINING A BENZIMIDAZOLE DERIVATIVE AS AN ACTIVE SUBSTANCE |
AU2003301436A1 (en) * | 2002-10-17 | 2004-05-04 | Amgen Inc. | Benzimidazole derivatives and their use as vanilloid receptor ligands |
WO2005051949A1 (en) * | 2003-11-26 | 2005-06-09 | Dainippon Sumitomo Pharma Co., Ltd. | Novel condensed imidazole derivative |
DE102004017932A1 (en) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New alkyne compounds having MCH antagonist activity and medicaments containing these compounds |
WO2006010283A1 (en) | 2004-07-28 | 2006-02-02 | Universität Zürich | Prevention and treatment of thrombus formation |
US20100267717A1 (en) | 2005-07-29 | 2010-10-21 | 4Sc Ag | Novel Heterocyclic NF-kB Inhibitors |
US7601745B2 (en) | 2004-09-27 | 2009-10-13 | 4Sc Ag | Heterocyclic NF-kB inhibitors |
DE102005012874A1 (en) | 2005-03-19 | 2006-09-21 | Sanofi-Aventis Deutschland Gmbh | Amide-substituted 8-N-benzimidazoles, process for their preparation and their use as pharmaceuticals |
DE102005012875B4 (en) | 2005-03-19 | 2006-11-16 | Sanofi-Aventis Deutschland Gmbh | Use of amino-substituted 8-N-benzimidazoles |
EP1868959B1 (en) * | 2005-04-06 | 2011-08-17 | North Carolina State University | Method of preparing dense, shaped articles constructed of a refractory material |
EP1739078A1 (en) | 2005-05-30 | 2007-01-03 | Jerini AG | Antagonists of C5a-receptor |
JP2009510134A (en) | 2005-10-07 | 2009-03-12 | ワラタ ファーマシューティカルズ, インコーポレイテッド | Combination use of DPP-IV inhibitor and gastrin compound |
US20090239880A1 (en) | 2006-07-03 | 2009-09-24 | Ulrik Svane Sorensen | Combinations of monoamine reuptake inhibitors and potassium channel activators |
ES2373587T3 (en) | 2006-08-23 | 2012-02-06 | Pfizer Products Inc. | PIRIMIDONE COMPOUNDS AS INHIBITORS OF GSK-3. |
US20080186971A1 (en) | 2007-02-02 | 2008-08-07 | Tarari, Inc. | Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic |
WO2008100977A2 (en) | 2007-02-14 | 2008-08-21 | N.V. Organon | Carbamates therapeutic release agents as amidase inhibitors |
WO2008153701A1 (en) * | 2007-05-24 | 2008-12-18 | Schering Corporation | Compounds for inhibiting ksp kinesin activity |
JP2010535234A (en) | 2007-07-30 | 2010-11-18 | オースペックス・ファーマシューティカルズ・インコーポレイテッド | Substituted indole |
US8933013B2 (en) | 2007-12-05 | 2015-01-13 | Nono Inc. | Co-administration of an agent linked to an internalization peptide with an anti-inflammatory |
US20090176792A1 (en) | 2008-01-07 | 2009-07-09 | Auspex Pharmaceuticals, Inc. | Substituted dibenzhydrylpiperazines |
KR20100101054A (en) | 2009-03-07 | 2010-09-16 | 주식회사 메디젠텍 | Composition for treating or preventing nuclear export of gsk3- mediated disease including compound for inhibiting nuclear export of gsk3 |
WO2011023812A1 (en) | 2009-08-27 | 2011-03-03 | Novasaid Ab | Microsomal prostaglandin e synthase-1 (mpges1) inhibitors |
EP2368876A1 (en) | 2010-03-01 | 2011-09-28 | Sanofi | Derivatives of aminoindanes, their preparation and their application in therapeutics |
US20140018540A1 (en) | 2010-12-14 | 2014-01-16 | Electrophoretics Limited | Casein kinase 1delta (ck 1delta) inhibitors |
WO2012098281A2 (en) | 2011-01-19 | 2012-07-26 | Universidad Miguel Hernández De Elche | Trp-receptor-modulating peptides and uses thereof |
ES2786298T3 (en) | 2011-03-03 | 2020-10-09 | Zalicus Pharmaceuticals Ltd | Benzimidazole sodium channel inhibitors |
US20130303462A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
EP2698367A1 (en) * | 2012-08-14 | 2014-02-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Benzimidazoles for the treatment of cancer |
GB201223265D0 (en) | 2012-12-21 | 2013-02-06 | Selvita Sa | Novel benzimidazole derivatives as kinase inhibitors |
CA2901577A1 (en) | 2013-02-18 | 2014-08-21 | The Scripps Research Institute | Modulators of vasopressin receptors with therapeutic potential |
EP2968536B1 (en) | 2013-03-13 | 2023-06-28 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Methods for modulating chemotherapeutic cytotoxicity |
SG11201510409QA (en) | 2013-06-21 | 2016-01-28 | Zenith Epigenetics Corp | Novel bicyclic bromodomain inhibitors |
US9828348B2 (en) | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
AU2015295248B2 (en) | 2014-07-31 | 2019-05-16 | Institut Pasteur Korea | 2-amino-benzimidazole derivatives and their use as 5-lipoxygenase and/or prostaglandin e synthase inhibitors |
TW201643138A (en) | 2015-04-17 | 2016-12-16 | 佛瑪治療公司 | 3-spiro-7-hydroxamic acid tetralins as HDAC inhibitors |
WO2017052394A1 (en) | 2015-09-23 | 2017-03-30 | Uniwersytet Jagielloński | Imidazopyridine compounds and their use as 5-ht6 receptor ligands |
WO2017060488A1 (en) | 2015-10-09 | 2017-04-13 | Almirall, S.A. | New trpa1 antagonists |
WO2017064068A1 (en) | 2015-10-14 | 2017-04-20 | Almirall, S.A. | New trpa1 antagonists |
GB201603311D0 (en) | 2016-02-25 | 2016-04-13 | Jakobsson Per Johan | New uses and methods |
US11091482B2 (en) | 2016-08-23 | 2021-08-17 | Ardelyx, Inc. | Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators |
US10501421B1 (en) * | 2017-01-27 | 2019-12-10 | Vanderbilt University | Substituted benzimidazoles as modulators of Ras signaling |
-
2018
- 2018-10-18 MX MX2020003993A patent/MX2020003993A/en unknown
- 2018-10-18 MA MA050413A patent/MA50413A/en unknown
- 2018-10-18 AU AU2018351059A patent/AU2018351059B2/en active Active
- 2018-10-18 BR BR112020007589A patent/BR112020007589A8/en unknown
- 2018-10-18 SG SG11202003502VA patent/SG11202003502VA/en unknown
- 2018-10-18 IL IL273839A patent/IL273839B/en unknown
- 2018-10-18 KR KR1020207013744A patent/KR20200074965A/en not_active Application Discontinuation
- 2018-10-18 JP JP2020521577A patent/JP7450534B2/en active Active
- 2018-10-18 CA CA3079081A patent/CA3079081A1/en active Pending
- 2018-10-18 CN CN201880077655.5A patent/CN111417394B/en active Active
- 2018-10-18 WO PCT/US2018/056484 patent/WO2019079578A1/en unknown
- 2018-10-18 EP EP18867844.5A patent/EP3697410A4/en active Pending
- 2018-10-18 US US16/754,349 patent/US11332459B2/en active Active
- 2018-10-19 TW TW107137075A patent/TWI816704B/en active
- 2018-10-19 UY UY0001037941A patent/UY37941A/en not_active Application Discontinuation
-
2020
- 2020-04-14 PH PH12020550265A patent/PH12020550265A1/en unknown
- 2020-04-16 CO CONC2020/0004669A patent/CO2020004669A2/en unknown
- 2020-04-16 CL CL2020001020A patent/CL2020001020A1/en unknown
- 2020-04-17 SA SA520411787A patent/SA520411787B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112020007589A2 (en) | 2020-09-24 |
CA3079081A1 (en) | 2019-04-25 |
BR112020007589A8 (en) | 2022-08-02 |
TW201930284A (en) | 2019-08-01 |
SA520411787B1 (en) | 2022-08-29 |
UY37941A (en) | 2019-04-30 |
CN111417394B (en) | 2023-11-07 |
PH12020550265A1 (en) | 2021-03-01 |
EP3697410A1 (en) | 2020-08-26 |
WO2019079578A1 (en) | 2019-04-25 |
US20200308145A1 (en) | 2020-10-01 |
US11332459B2 (en) | 2022-05-17 |
KR20200074965A (en) | 2020-06-25 |
EP3697410A4 (en) | 2021-08-11 |
SG11202003502VA (en) | 2020-05-28 |
MA50413A (en) | 2020-08-26 |
AU2018351059A1 (en) | 2020-04-23 |
TWI816704B (en) | 2023-10-01 |
JP2021500332A (en) | 2021-01-07 |
JP7450534B2 (en) | 2024-03-15 |
IL273839B (en) | 2022-09-01 |
CN111417394A (en) | 2020-07-14 |
CO2020004669A2 (en) | 2020-05-05 |
MX2020003993A (en) | 2020-08-13 |
AU2018351059B2 (en) | 2022-05-12 |
IL273839A (en) | 2020-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2020001020A1 (en) | Benzimidazole derivatives and their uses. | |
DOP2022000124A (en) | PYRAZOLIL DERIVATIVES USEFUL AS ANTICANCER AGENTS | |
CR20190124A (en) | Amino pyrimidine ssao inhibitors | |
PE20151501A1 (en) | PRMT5 INHIBITORS AND THEIR USES | |
CL2020000610A1 (en) | Bisamide compounds that activate the sarcomere and their uses. | |
UY35273A (en) | TIADIAZOL, ANALOGS OF THE SAME, AND METHODS FOR THE TREATMENT OF CONDITIONS RELATED TO DEFICIENT OF SMN | |
CO2021002977A2 (en) | Dimethylaminoazetidinamines as jak inhibitors | |
UY38096A (en) | ARGINASE INHIBITORS AND THEIR METHODS OF USE | |
BR112017016817A2 (en) | heterocyclic derivatives formulated as fgfr4 inhibitors | |
MX2020011405A (en) | Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (rorï) and pharmaceutical uses thereof. | |
CY1124251T1 (en) | CARBOXAMIDE DERIVATIVES | |
CO2019002523A2 (en) | Dopamine-β-hydroxylase inhibitors of the blood-brain barrier | |
UY37837A (en) | NEW HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CDK8 / 19 | |
NI202100012A (en) | N-SUBSTITUTED DIOXOCYCLOBUTENYLAMINO-3-HYDROXY-PICOLINAMIDES USEFUL AS CCR6 INHIBITORS | |
UY36123A (en) | CARBOXAMIDE DERIVATIVES | |
ECSP19084722A (en) | 5,6-FUSED BICYCLIC COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | |
CU20190042A7 (en) | COMPOUNDS DERIVED FROM NAPHTHYRIDINONE | |
CO2019002616A2 (en) | Indazole compounds for use in tendon and / or ligament injuries | |
DOP2020000088A (en) | PYRIDINONE DERIVATIVES AND THEIR USE AS SELECTIVE ALK – 2 INHIBITORS. | |
EA201891319A1 (en) | COMPOUNDS OF ALKYDYDYDROCHINOLINSULPHONAMIDE | |
CY1124087T1 (en) | PYRIDOQUINAZOLINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | |
UY38133A (en) | NEW INHIBITORS FROM CDK8 / 19 | |
EA202090982A1 (en) | BENZIMIDAZOLE DERIVATIVES AND VARIANTS OF THEIR APPLICATION | |
CU20160170A7 (en) | CARBOXAMIDE DERIVATIVES | |
AR105921A1 (en) | THERAPEUTIC COMPOUNDS FOR PAIN AND SYNTHESIS OF THESE |