CL2019003520A1 - Anticuerpos que se unen específicamente a pd-1 y procedimientos de uso. - Google Patents
Anticuerpos que se unen específicamente a pd-1 y procedimientos de uso.Info
- Publication number
- CL2019003520A1 CL2019003520A1 CL2019003520A CL2019003520A CL2019003520A1 CL 2019003520 A1 CL2019003520 A1 CL 2019003520A1 CL 2019003520 A CL2019003520 A CL 2019003520A CL 2019003520 A CL2019003520 A CL 2019003520A CL 2019003520 A1 CL2019003520 A1 CL 2019003520A1
- Authority
- CL
- Chile
- Prior art keywords
- antibodies
- specifically bind
- procedures
- fragments
- inletter
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
LOS ANTICUERPOS QUE SE UNEN ESPECÍFICAMENTE A PD-1 O FRAGMENTOS DE UNIÓN AL ANTÍGENO DE ESTOS, LOS POLINUCLEÓTIDOS QUE CODIFICAN LOS ANTICUERPOS O FRAGMENTOS, Y LOS MÉTODOS DE FABRICACIÓN Y USO DE LOS ANTERIORES SON ÚTILES EN EL TRATAMIENTO DE TRASTORNOS INFLAMATORIOS O INMUNITARIOS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762515188P | 2017-06-05 | 2017-06-05 | |
US201862648114P | 2018-03-26 | 2018-03-26 | |
US201862673185P | 2018-05-18 | 2018-05-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019003520A1 true CL2019003520A1 (es) | 2020-05-08 |
Family
ID=64562613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019003520A CL2019003520A1 (es) | 2017-06-05 | 2019-12-02 | Anticuerpos que se unen específicamente a pd-1 y procedimientos de uso. |
Country Status (23)
Country | Link |
---|---|
US (3) | US10995149B2 (es) |
EP (1) | EP3634995A4 (es) |
JP (1) | JP7235733B2 (es) |
KR (1) | KR20200014414A (es) |
CN (1) | CN110997712B (es) |
AU (1) | AU2018282094A1 (es) |
BR (1) | BR112019025574A2 (es) |
CA (1) | CA3065516A1 (es) |
CL (1) | CL2019003520A1 (es) |
CO (1) | CO2019013935A2 (es) |
CR (1) | CR20190550A (es) |
EC (1) | ECSP19086810A (es) |
IL (1) | IL271009A (es) |
MA (1) | MA52459A (es) |
MX (1) | MX2019014577A (es) |
NI (1) | NI201900123A (es) |
PE (1) | PE20200294A1 (es) |
PH (1) | PH12019502755A1 (es) |
TW (1) | TWI806873B (es) |
UA (1) | UA128035C2 (es) |
UY (1) | UY37761A (es) |
WO (1) | WO2018226580A2 (es) |
ZA (1) | ZA202000051B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3630112B1 (en) * | 2017-06-02 | 2024-01-31 | Bayer HealthCare LLC | Combination of regorafenib and nivolumab for treating cancer |
TWI708787B (zh) | 2018-03-02 | 2020-11-01 | 美商美國禮來大藥廠 | Pd-1促效劑抗體及其用途 |
US20220298211A1 (en) * | 2019-06-04 | 2022-09-22 | Qiang Chen | PLANT-PRODUCED mABs AGAINST CHIKUNGUNYA VIRUS WITH ENHANCED EFFECTOR FUNCTION AND EFFICACY |
EP3998081A4 (en) | 2019-07-05 | 2023-07-12 | Ono Pharmaceutical Co., Ltd. | TREATMENT OF BLOOD CANCER WITH PD-1/CD3 DUAL SPECIFICITY PROTEIN |
CN114174343A (zh) * | 2019-07-30 | 2022-03-11 | 小野药品工业株式会社 | 双特异性抗体 |
EP4011918A4 (en) | 2019-08-08 | 2023-08-23 | ONO Pharmaceutical Co., Ltd. | DUAL SPECIFIC PROTEIN |
CA3181776A1 (en) | 2020-05-26 | 2021-12-02 | Boehringer Ingelheim International Gmbh | Anti-pd-1 antibodies |
WO2022156773A1 (en) * | 2021-01-21 | 2022-07-28 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd | Protein complexes targeting il12 pathway |
IL307887A (en) | 2021-05-13 | 2023-12-01 | Foundation For Biomedical Res And Innovation At Kobe | An anti-human PD-1 agonist antibody and a pharmaceutical preparation comprising the antibody for the treatment or prevention of inflammatory diseases |
CN117794948A (zh) * | 2021-06-18 | 2024-03-29 | 特里尼生物公司 | 结合人纤维蛋白或纤维蛋白原γC结构域的抗体及其使用方法 |
TW202323301A (zh) | 2021-11-19 | 2023-06-16 | 英商米羅比奧有限公司 | 經工程改造之pd-1抗體及其用途 |
WO2024010861A2 (en) * | 2022-07-06 | 2024-01-11 | Santa Ana Bio, Inc. | Methods and compositions for treating autoimmune, allergic and inflammatory diseases |
WO2024076990A1 (en) * | 2022-10-03 | 2024-04-11 | Therini Bio, Inc. | Multi-specific antigen binding proteins which bind human fibrin or fibrinogen ?c domain and vascular endothelial growth factor and methods of use |
CN116854820B (zh) * | 2023-06-26 | 2024-02-06 | 华中科技大学同济医学院附属协和医院 | Pd-1非阻断性清除抗体及其用途 |
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KR20160097336A (ko) | 2013-12-12 | 2016-08-17 | 스템센트알엑스 인코포레이티드 | 신규 항-dpep3 항체 및 이의 사용 방법 |
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KR102257154B1 (ko) | 2016-09-19 | 2021-05-28 | 셀진 코포레이션 | Pd-1 결합 단백질을 사용하는 면역 질환의 치료 방법 |
BR112019025035A2 (pt) | 2017-06-01 | 2020-06-30 | Compugen Ltd. | método para tratar câncer |
JP2020532991A (ja) | 2017-09-07 | 2020-11-19 | オーガスタ ユニバーシティ リサーチ インスティテュート,インコーポレーテッド | プログラム細胞死タンパク質1に対する抗体 |
TWI708787B (zh) | 2018-03-02 | 2020-11-01 | 美商美國禮來大藥廠 | Pd-1促效劑抗體及其用途 |
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2018
- 2018-06-04 MX MX2019014577A patent/MX2019014577A/es unknown
- 2018-06-04 JP JP2020516792A patent/JP7235733B2/ja active Active
- 2018-06-04 WO PCT/US2018/035843 patent/WO2018226580A2/en active Application Filing
- 2018-06-04 US US15/997,148 patent/US10995149B2/en active Active
- 2018-06-04 UA UAA201912296A patent/UA128035C2/uk unknown
- 2018-06-04 BR BR112019025574-5A patent/BR112019025574A2/pt unknown
- 2018-06-04 CN CN201880050979.XA patent/CN110997712B/zh active Active
- 2018-06-04 CR CR20190550A patent/CR20190550A/es unknown
- 2018-06-04 KR KR1020207000242A patent/KR20200014414A/ko not_active Application Discontinuation
- 2018-06-04 MA MA052459A patent/MA52459A/fr unknown
- 2018-06-04 EP EP18813493.6A patent/EP3634995A4/en active Pending
- 2018-06-04 CA CA3065516A patent/CA3065516A1/en active Pending
- 2018-06-04 PE PE2019002510A patent/PE20200294A1/es unknown
- 2018-06-04 AU AU2018282094A patent/AU2018282094A1/en active Pending
- 2018-06-05 TW TW107119358A patent/TWI806873B/zh active
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2019
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UY37761A (es) | 2019-01-02 |
EP3634995A2 (en) | 2020-04-15 |
CA3065516A1 (en) | 2018-12-13 |
JP2020522278A (ja) | 2020-07-30 |
MA52459A (fr) | 2021-03-10 |
TWI806873B (zh) | 2023-07-01 |
US20210102000A1 (en) | 2021-04-08 |
ZA202000051B (en) | 2021-07-28 |
US20180355061A1 (en) | 2018-12-13 |
PH12019502755A1 (en) | 2020-06-08 |
MX2019014577A (es) | 2020-07-29 |
TW201906863A (zh) | 2019-02-16 |
AU2018282094A1 (en) | 2019-12-12 |
KR20200014414A (ko) | 2020-02-10 |
EP3634995A4 (en) | 2021-06-09 |
US20230340155A1 (en) | 2023-10-26 |
WO2018226580A2 (en) | 2018-12-13 |
WO2018226580A3 (en) | 2019-01-31 |
UA128035C2 (uk) | 2024-03-20 |
ECSP19086810A (es) | 2020-02-28 |
PE20200294A1 (es) | 2020-02-05 |
IL271009A (en) | 2020-01-30 |
CR20190550A (es) | 2020-04-05 |
US11746161B2 (en) | 2023-09-05 |
CO2019013935A2 (es) | 2020-01-17 |
CN110997712B (zh) | 2024-03-19 |
NI201900123A (es) | 2020-12-01 |
JP7235733B2 (ja) | 2023-03-08 |
BR112019025574A2 (pt) | 2020-06-23 |
CN110997712A (zh) | 2020-04-10 |
US10995149B2 (en) | 2021-05-04 |
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