CL2019000534A1 - Inhibidores de cinasa de cremallera de leucina dual (dlk) para el tratamiento de enfermedades. - Google Patents
Inhibidores de cinasa de cremallera de leucina dual (dlk) para el tratamiento de enfermedades.Info
- Publication number
- CL2019000534A1 CL2019000534A1 CL2019000534A CL2019000534A CL2019000534A1 CL 2019000534 A1 CL2019000534 A1 CL 2019000534A1 CL 2019000534 A CL2019000534 A CL 2019000534A CL 2019000534 A CL2019000534 A CL 2019000534A CL 2019000534 A1 CL2019000534 A1 CL 2019000534A1
- Authority
- CL
- Chile
- Prior art keywords
- criminality
- chronicermality
- dlk
- disease
- treatment
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
EN EL PRESENTE DOCUMENTO SE DAN A CONOCER COMPUESTOS QUE INHIBEN LA ACTIVIDAD DE CINASA DE LA CINASA DE CREMALLERA DE LEUCINA DUAL (DLK) (MAP3K12), COMPOSICIONES FARMACÉUTICAS Y MÉTODOS DE TRATAMIENTO DE ENFERMEDADES MEDIADAS POR DLK, TALES COMO ENFERMEDADES NEUROLÓGICAS QUE RESULTAN DE LESIÓN TRAUMÁTICA AL SISTEMA NERVIOSO CENTRAL Y NEURONAS DEL SISTEMA NERVIOSO PERIFÉRICO (POR EJEMPLO, APOPLEJÍA, LESIÓN CEREBRAL TRAUMÁTICA, LESIÓN DE MÉDULA ESPINAL), O QUE RESULTAN DE UN PADECIMIENTO NEURODEGENERATIVO CRÓNICO (POR EJEMPLO, ENFERMEDAD DE ALZHEIMER, DEMENCIA FRONTOTEMPORAL, ENFERMEDAD DE PARKINSON, ENFERMEDAD DE HUNTINGTON, ESCLEROSIS LATERAL AMIOTRÓFICA, ATAXIA ESPINOCEREBELAR, PARÁLISIS SUPRANUCLEAR PROGRESIVA, ENFERMEDAD DE CUERPOS DE LEWY, ENFERMEDAD DE KENNEDY Y OTROS PADECIMIENTOS RELACIONADOS), DE NEUROPATÍAS QUE RESULTAN DE DAÑO NEUROLÓGICO (NEUROPATÍA PERIFÉRICA INDUCIDA POR QUIMIOTERAPIA, NEUROPATÍA DIABÉTICA Y TRASTORNOS RELACIONADOS) Y DE TRASTORNOS COGNITIVOS OCASIONADOS POR INTERVENCIÓN FARMACOLÓGICA (POR EJEMPLO, TRASTORNO COGNITIVO INDUCIDO POR QUIMIOTERAPIA, TAMBIÉN CONOCIDO COMO QUIMIOCEREBRO).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662380822P | 2016-08-29 | 2016-08-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019000534A1 true CL2019000534A1 (es) | 2019-08-02 |
Family
ID=61240329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019000534A CL2019000534A1 (es) | 2016-08-29 | 2019-02-28 | Inhibidores de cinasa de cremallera de leucina dual (dlk) para el tratamiento de enfermedades. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20180057507A1 (es) |
EP (1) | EP3503889A1 (es) |
JP (1) | JP2019528319A (es) |
KR (1) | KR20190040068A (es) |
CN (1) | CN109789132A (es) |
AU (1) | AU2017321313A1 (es) |
BR (1) | BR112019004243A2 (es) |
CA (1) | CA3035195A1 (es) |
CL (1) | CL2019000534A1 (es) |
CO (1) | CO2019002839A2 (es) |
EA (1) | EA201990450A1 (es) |
EC (1) | ECSP19021843A (es) |
MX (1) | MX2019002444A (es) |
WO (1) | WO2018044808A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7128816B2 (ja) | 2016-12-08 | 2022-08-31 | ボード オブ レジェンツ,ザ ユニバーシティ オブ テキサス システム | 疾患の治療のための二重ロイシンジッパー(dlk)キナーゼのビシクロ[1.1.1]ペンタン阻害剤 |
US11560366B2 (en) * | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
AU2021336300A1 (en) | 2020-09-02 | 2023-03-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | LZK-targeting degraders and methods of use |
IL301817A (en) * | 2020-10-13 | 2023-06-01 | Univ Johns Hopkins | Modified 4-([4,2,1]triazolo[5,1-a]pyridin-6-yl)thiophene-2-carboxamide histories and their use |
CN114605497B (zh) * | 2021-02-10 | 2023-04-28 | 北京欣安诚科技有限公司 | 一种dapk1磷酸化底物的人工小分子干扰肽及其制药用途 |
CA3229861A1 (en) | 2021-09-01 | 2023-03-09 | John F. BROGNARD | Mixed lineage kinase inhibitors and methods of use |
CN115770239B (zh) * | 2022-12-05 | 2024-01-30 | 南京中医药大学 | 呋喃并色酮及药学上可接受的盐在制备治疗周围神经病变的药物中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006524702A (ja) * | 2003-04-25 | 2006-11-02 | カイロン コーポレイション | ピリジル置換ケトライド抗体 |
WO2004096823A2 (en) * | 2003-04-25 | 2004-11-11 | Chiron Corporation | Novel ketolide derivatives |
TW200944520A (en) * | 2008-01-29 | 2009-11-01 | Glaxo Group Ltd | Spiro compounds as NPY Y5 receptor antagonists |
FR2928923B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
WO2012082817A1 (en) * | 2010-12-16 | 2012-06-21 | Boehringer Ingelheim International Gmbh | Biarylamide inhibitors of leukotriene production |
KR20150023445A (ko) * | 2012-05-22 | 2015-03-05 | 에프. 호프만-라 로슈 아게 | 치환된 다이피리딜아민 및 이의 용도 |
CA2896187A1 (en) * | 2013-01-18 | 2014-07-24 | F. Hoffmann-La Roche Ag | 3-substituted pyrazoles and use as dlk inhibitors |
PE20200447A1 (es) * | 2013-05-01 | 2020-02-28 | Hoffmann La Roche | Compuestos de biheteroarilo y usos de los mismos |
MX2016008110A (es) * | 2013-12-20 | 2016-08-19 | Hoffmann La Roche | Derivados de pirazol como inhibidores de la cinasa de cremallera de leucina dual (dlk) y usos de los mismos. |
-
2017
- 2017-08-28 KR KR1020197008981A patent/KR20190040068A/ko unknown
- 2017-08-28 AU AU2017321313A patent/AU2017321313A1/en not_active Abandoned
- 2017-08-28 WO PCT/US2017/048941 patent/WO2018044808A1/en active Application Filing
- 2017-08-28 CN CN201780057801.3A patent/CN109789132A/zh active Pending
- 2017-08-28 JP JP2019531562A patent/JP2019528319A/ja active Pending
- 2017-08-28 EA EA201990450A patent/EA201990450A1/ru unknown
- 2017-08-28 CA CA3035195A patent/CA3035195A1/en not_active Abandoned
- 2017-08-28 BR BR112019004243A patent/BR112019004243A2/pt not_active Application Discontinuation
- 2017-08-28 EP EP17847316.1A patent/EP3503889A1/en not_active Withdrawn
- 2017-08-28 US US15/688,554 patent/US20180057507A1/en not_active Abandoned
- 2017-08-28 MX MX2019002444A patent/MX2019002444A/es unknown
-
2019
- 2019-02-28 CL CL2019000534A patent/CL2019000534A1/es unknown
- 2019-03-27 CO CONC2019/0002839A patent/CO2019002839A2/es unknown
- 2019-03-28 EC ECSENADI201921843A patent/ECSP19021843A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN109789132A (zh) | 2019-05-21 |
MX2019002444A (es) | 2019-09-02 |
CO2019002839A2 (es) | 2019-04-30 |
AU2017321313A1 (en) | 2019-03-21 |
ECSP19021843A (es) | 2019-05-31 |
EP3503889A1 (en) | 2019-07-03 |
JP2019528319A (ja) | 2019-10-10 |
BR112019004243A2 (pt) | 2019-06-04 |
CA3035195A1 (en) | 2018-03-08 |
EA201990450A1 (ru) | 2019-07-31 |
US20180057507A1 (en) | 2018-03-01 |
WO2018044808A1 (en) | 2018-03-08 |
KR20190040068A (ko) | 2019-04-16 |
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