CL2017002549A1 - Use of a bismuth-thiol (bt) composition, which is used to prepare a medication useful for the treatment of an open wound that has or is at risk of having a bacterial biofilm infection. - Google Patents
Use of a bismuth-thiol (bt) composition, which is used to prepare a medication useful for the treatment of an open wound that has or is at risk of having a bacterial biofilm infection.Info
- Publication number
- CL2017002549A1 CL2017002549A1 CL2017002549A CL2017002549A CL2017002549A1 CL 2017002549 A1 CL2017002549 A1 CL 2017002549A1 CL 2017002549 A CL2017002549 A CL 2017002549A CL 2017002549 A CL2017002549 A CL 2017002549A CL 2017002549 A1 CL2017002549 A1 CL 2017002549A1
- Authority
- CL
- Chile
- Prior art keywords
- composition
- bismuth
- thiol
- risk
- prepare
- Prior art date
Links
- BIGYLAKFCGVRAN-UHFFFAOYSA-N 1,3,4-thiadiazolidine-2,5-dithione Chemical compound S=C1NNC(=S)S1 BIGYLAKFCGVRAN-UHFFFAOYSA-N 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 3
- 206010052428 Wound Diseases 0.000 title abstract 2
- 230000001580 bacterial effect Effects 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000011859 microparticle Substances 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- -1 BT compound Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/29—Antimony or bismuth compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Abstract
<p>la invención divulga uso de una composición de bismuto-tiol (BT), CARACTERIZADO porque sirve para preparar un medicamento útil para el tratamiento de una herida abierta que tiene o que está en riesgo de tener una infección de biopelícula bacteriana, en donde la composición BT comprende una suspensión monodispersa de micropartículas que comprenden un compuesto de BT, en donde en dicha suspensión, al menos el 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% o 99% de dichas micropartículas tienen un diámetro volumétrico medio de aproximadamente 0,4 μm a aproximadamente 10μm.</p><p> The invention discloses the use of a bismuth-thiol (BT) composition, CHARACTERIZED because it serves to prepare a medicament useful for the treatment of an open wound that has or is at risk of having a bacterial biofilm infection, wherein The BT composition comprises a monodispersed suspension of microparticles comprising a BT compound, wherein in said suspension, at least 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96 %, 97%, 98% or 99% of said microparticles have an average volumetric diameter of about 0.4 µm to about 10μm. </p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37318810P | 2010-08-12 | 2010-08-12 | |
PCT/US2011/023549 WO2011097347A2 (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2017002549A1 true CL2017002549A1 (en) | 2018-05-11 |
Family
ID=44356067
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2013000430A CL2013000430A1 (en) | 2010-08-12 | 2013-02-12 | Method to protect a plant against a bacterial, fungal or viral pathogen because it comprises contacting the plant with bismuth thiol (bt); method for overcoming antibiotic resistance in a plant, in or on which a bacterial plant pathogen resistant to antibiotics is present. |
CL2017002549A CL2017002549A1 (en) | 2010-08-12 | 2017-10-10 | Use of a bismuth-thiol (bt) composition, which is used to prepare a medication useful for the treatment of an open wound that has or is at risk of having a bacterial biofilm infection. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2013000430A CL2013000430A1 (en) | 2010-08-12 | 2013-02-12 | Method to protect a plant against a bacterial, fungal or viral pathogen because it comprises contacting the plant with bismuth thiol (bt); method for overcoming antibiotic resistance in a plant, in or on which a bacterial plant pathogen resistant to antibiotics is present. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP2603083A4 (en) |
JP (7) | JP2013535506A (en) |
KR (6) | KR20200015814A (en) |
CN (2) | CN105766990B (en) |
AU (3) | AU2011289338B2 (en) |
BR (2) | BR112012019286A2 (en) |
CA (1) | CA2807993C (en) |
CL (2) | CL2013000430A1 (en) |
IL (3) | IL224684A (en) |
MX (4) | MX371047B (en) |
NZ (1) | NZ606634A (en) |
PH (1) | PH12016502498A1 (en) |
RU (2) | RU2013110493A (en) |
SG (3) | SG10202001032RA (en) |
UA (1) | UA113616C2 (en) |
WO (1) | WO2012021754A2 (en) |
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JP5674684B2 (en) | 2009-02-03 | 2015-02-25 | マイクロビオン コーポレーション | Bismuth-thiol as a disinfectant for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
US9028878B2 (en) | 2009-02-03 | 2015-05-12 | Microbion Corporation | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
BR112012019286A2 (en) * | 2010-02-03 | 2018-06-26 | Microbion Corp | bismuththiols as an antiseptic for biomedical uses, including treatment of bacterial biofilms and other uses |
CA2907173A1 (en) * | 2013-03-18 | 2014-09-25 | Theranovis Gmbh & Co. Kg | Composition for oral care |
RU2525200C1 (en) * | 2013-04-09 | 2014-08-10 | Алексей Георгиевич Бородкин | Agent for protection and repair of wound of trees |
KR101703732B1 (en) * | 2013-11-07 | 2017-02-07 | (주)아모레퍼시픽 | Anti-inflammatory composition containing enzymated camellia japonica seed oil |
WO2017145142A1 (en) | 2016-02-25 | 2017-08-31 | Nobio Ltd. | Micro and nanoparticulate compositions comprising anti-microbially active groups |
BR112020004156A2 (en) | 2017-08-30 | 2020-09-08 | Nobio Ltd. | antimicrobial particles and methods of applying them |
CN107950536A (en) * | 2017-12-04 | 2018-04-24 | 刘志伟 | A kind of bactericidal composition containing Bravo |
CN108839186B (en) * | 2018-05-15 | 2021-02-26 | 阜南县金威工艺品有限公司 | Mildew-proof treatment method for mulberry twig woven product |
BR112021001725A2 (en) | 2018-07-31 | 2021-04-27 | Microbion Corporation | bismuth-thiol compositions and methods of treating wounds |
CA3107760A1 (en) | 2018-07-31 | 2020-02-06 | Microbion Corporation | Bismuth-thiol compositions and methods of use |
KR101990253B1 (en) * | 2018-11-22 | 2019-06-17 | 하봉호 | Container type mushroom growing apparatus |
CN109997856B (en) * | 2019-04-15 | 2020-11-03 | 广西大学 | Composition of small molecular compound and application thereof |
KR102126721B1 (en) * | 2019-07-16 | 2020-06-25 | (주)인트론바이오테크놀로지 | Novel Enterobacter aerogenes bacteriophage Ent-AEP-1 and its use for preventing proliferation of Enterobacter aerogenes and Enterobacter cloacae |
JP7458622B2 (en) * | 2019-09-18 | 2024-04-01 | 学校法人東京農業大学 | Substances that reduce the resistance of antibiotic-resistant microorganisms and methods for reducing the resistance of antibiotic-resistant microorganisms |
CN110663672B (en) * | 2019-11-13 | 2024-04-26 | 南京林业大学 | Thread-driven root pesticide application head |
US11479655B2 (en) * | 2020-01-15 | 2022-10-25 | The Boeing Company | Compositions for use with polysulfide sealants and related methods |
KR102197719B1 (en) | 2020-05-07 | 2021-01-04 | 곽태진 | Cuttlefish breeding system |
CN111856546B (en) * | 2020-06-23 | 2022-07-29 | 中国辐射防护研究院 | Sample preparation method for radiochemical analysis of Cs-137 in marine organism ash |
CN113969300A (en) * | 2020-07-23 | 2022-01-25 | 启迪禾美生物科技(嘉兴)有限公司 | Eucalyptus leaf composite active extract process and antibacterial application thereof |
CN112640907B (en) * | 2021-01-19 | 2021-11-16 | 西南大学 | Novel application of lipoic acid in inhibiting plant fungal pathogenic bacteria and method for preventing and treating citrus fruit postharvest fungal diseases |
KR102431000B1 (en) * | 2021-07-22 | 2022-08-11 | 농업회사법인 주식회사 아그로비즈 | Composition for an autoimmune builder of plants containing aspirin and benzothiazole, and method of using the same |
EP4310192A1 (en) * | 2022-07-21 | 2024-01-24 | C4Diagnostics | Method of determining the existence and/or degree of resistance of microorganisms to antimicrobial agents |
CN115323778B (en) * | 2022-08-16 | 2023-07-18 | 汕头市润丰纺织科技实业有限公司 | Chitosan-I type collagen amino acid composite antibacterial finishing liquid, preparation method thereof and antibacterial fabric |
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JP5674684B2 (en) * | 2009-02-03 | 2015-02-25 | マイクロビオン コーポレーション | Bismuth-thiol as a disinfectant for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
BR112012019286A2 (en) * | 2010-02-03 | 2018-06-26 | Microbion Corp | bismuththiols as an antiseptic for biomedical uses, including treatment of bacterial biofilms and other uses |
-
2011
- 2011-02-03 BR BR112012019286A patent/BR112012019286A2/en not_active Application Discontinuation
- 2011-02-03 MX MX2016010269A patent/MX371047B/en unknown
- 2011-02-03 KR KR1020207003093A patent/KR20200015814A/en not_active Application Discontinuation
- 2011-02-03 KR KR1020177034637A patent/KR101966867B1/en active IP Right Grant
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