CL2017002451A1 - Compuestos heterocíclicos novedosos y su uso en la prevención o tratamiento de las infecciones bacterianas - Google Patents

Compuestos heterocíclicos novedosos y su uso en la prevención o tratamiento de las infecciones bacterianas

Info

Publication number
CL2017002451A1
CL2017002451A1 CL2017002451A CL2017002451A CL2017002451A1 CL 2017002451 A1 CL2017002451 A1 CL 2017002451A1 CL 2017002451 A CL2017002451 A CL 2017002451A CL 2017002451 A CL2017002451 A CL 2017002451A CL 2017002451 A1 CL2017002451 A1 CL 2017002451A1
Authority
CL
Chile
Prior art keywords
bacterial infections
heterocyclic compounds
prevention
treatment
novel heterocyclic
Prior art date
Application number
CL2017002451A
Other languages
English (en)
Inventor
Strat Frédéric Le
Sophie Chasset
Julien Barbion
Julie Brias
Audrey Caravano
Fabien Faivre
Sophie Vomscheid
Francis Chevreuil
Benoît Ledoussal
Sébastien Richard
Christophe Simon
Nicolas Lecointe
Original Assignee
Mutabilis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP15305473.9A external-priority patent/EP3075733A1/en
Application filed by Mutabilis filed Critical Mutabilis
Publication of CL2017002451A1 publication Critical patent/CL2017002451A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

<p>LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS HETEROCÍCLICOS, SU PROCEDIMIENTO DE PREPARACIÓN, COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN ESTOS COMPUESTOS Y EL USO DE LAS MISMAS, OPCIONALMENTE EN COMBINACIÓN CON OTROS AGENTES ANTIBACTERIANOS Y/O COMPUESTOS BETA-LACTÁMICOS, PARA LA PREVENCIÓN O TRATAMIENTO DE LAS INFECCIONES BACTERIANAS. LA PRESENTE INVENCIÓN TAMBIÉN SE REFIERE AL USO DE ESTOS COMPUESTOS COMO INHIBIDORES DE Β-LACTAMASA Y/O AGENTES ANTIBACTERIANOS.</p>
CL2017002451A 2015-03-31 2017-09-28 Compuestos heterocíclicos novedosos y su uso en la prevención o tratamiento de las infecciones bacterianas CL2017002451A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15305473.9A EP3075733A1 (en) 2015-03-31 2015-03-31 Novel heterocyclic compounds and their use in preventing or treating bacterial infections
EP16305073 2016-01-26

Publications (1)

Publication Number Publication Date
CL2017002451A1 true CL2017002451A1 (es) 2018-04-20

Family

ID=55642467

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017002451A CL2017002451A1 (es) 2015-03-31 2017-09-28 Compuestos heterocíclicos novedosos y su uso en la prevención o tratamiento de las infecciones bacterianas

Country Status (13)

Country Link
US (1) US10072006B2 (es)
EP (1) EP3277686B1 (es)
JP (1) JP2018510202A (es)
KR (1) KR20170132301A (es)
CN (1) CN107531708A (es)
AU (1) AU2016239209A1 (es)
BR (1) BR112017020796A2 (es)
CA (1) CA2980085A1 (es)
CL (1) CL2017002451A1 (es)
MX (1) MX2017012535A (es)
RU (1) RU2017133660A (es)
TW (1) TW201643164A (es)
WO (1) WO2016156348A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107580595B (zh) * 2015-05-07 2020-09-18 拜欧蒂姆公司 杂环化合物及它们在预防或治疗细菌感染中的应用
IL289686B2 (en) * 2016-09-16 2023-03-01 Entasis Therapeutics Ltd Beta-lactamase inhibitor compounds
EP3300736B1 (en) * 2016-09-30 2021-05-05 Mutabilis Composition comprising antibiotic compound and an heterocyclic compound and their use in preventing or treating bacterial infections
EP3357924A1 (en) * 2017-02-06 2018-08-08 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
CN109942579B (zh) * 2019-04-18 2021-06-22 成都千禧莱医药科技有限公司 β-内酰胺酶抑制剂含脲双环化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
AR090539A1 (es) 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
WO2014141132A1 (en) * 2013-03-14 2014-09-18 Naeja Pharmaceutical Inc. NEW HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS

Also Published As

Publication number Publication date
MX2017012535A (es) 2018-07-06
TW201643164A (zh) 2016-12-16
JP2018510202A (ja) 2018-04-12
US10072006B2 (en) 2018-09-11
KR20170132301A (ko) 2017-12-01
RU2017133660A (ru) 2019-03-28
CA2980085A1 (en) 2016-10-06
EP3277686A1 (en) 2018-02-07
AU2016239209A1 (en) 2017-10-12
US20180086761A1 (en) 2018-03-29
BR112017020796A2 (pt) 2018-06-26
EP3277686B1 (en) 2020-07-22
WO2016156348A1 (en) 2016-10-06
RU2017133660A3 (es) 2019-08-22
CN107531708A (zh) 2018-01-02

Similar Documents

Publication Publication Date Title
CL2017002482A1 (es) Compuestos heterocíclicos y su uso en la prevención o tratamiento de las infecciones bacterianas
CL2017002650A1 (es) Compuestos novedosos
CL2017003142A1 (es) Composiciones que comprenden cepas bacterianas
CL2017002451A1 (es) Compuestos heterocíclicos novedosos y su uso en la prevención o tratamiento de las infecciones bacterianas
SV2017005461A (es) Benzamidas sustituidas con 1,3-tiazol-2-ilo
EA201692301A1 (ru) Производные бороновой кислоты и их терапевтическое применение
CL2016002027A1 (es) Ciclopropilamina como inhibidor de la lsd1
EA201691988A1 (ru) Производные бороновой кислоты и их терапевтическое применение
CL2016000698A1 (es) Derivados de quinolizina sustituidos útiles como inhibidores de integrasa del vih
CL2016001231A1 (es) Compuestos de inhibidor de autotaxina
CL2016002072A1 (es) 2-amino-3,5,5-trifluoro-3,4,5,6-tetrahidropiridinas como inhibidores de bace1 para el tratamiento de la enfermedad de alzheimer
CL2015000295A1 (es) Compuestos derivados de alquilpirimidina; composicion farmaceutica que los comprende; uso para el tratamiento de infecciones víricas y otras enfermedades.
CL2017002803A1 (es) Compuestos heterocíclicos y su uso en la prevención o tratamiento de las infecciones bacterianas
CL2017001923A1 (es) Derivados de 9h-pirrolo-dipiridina
CU20190101A7 (es) Imidazopirimidinas diazabicíclicas sustituidas
DOP2016000253A (es) Nuevos compuestos
CR20170425A (es) Nuevas proteínas específicas para pioverdina y pioquelina
CL2015003019A1 (es) Derivados biaromáticos antibacterianos
MX2021000189A (es) Compuestos heterociclicos que contienen bencilamina y composiciones utiles contra infeccion por micobacterias.
CL2016000568A1 (es) Compuestos derivados de 2h-indazol-2-il-n-hidroxi-2-metilsulfonil-2-metil-butanamida sustituidos o sus sales; sus composiciones farmacéuticas que los contiene y su uso para la prevención y/o tratamiento de infecciones bacterianas gram-negativas.
DOP2016000336A (es) Derivados de isoindolina para uso en el tratamiento de una infeccion viral
EA201892822A1 (ru) Новые антибактериальные соединения
DOP2018000066A (es) Compuestos útiles para inhibir ror-gamma-t
BR112016022722A2 (pt) pró-fármacos de inibidores da transcriptase reversa de hiv
CL2020001147A1 (es) Compuestos antibacterianos