CL2015002124A1 - Moduladores de receptores nmda de espiro-lactama y sus usos - Google Patents
Moduladores de receptores nmda de espiro-lactama y sus usosInfo
- Publication number
- CL2015002124A1 CL2015002124A1 CL2015002124A CL2015002124A CL2015002124A1 CL 2015002124 A1 CL2015002124 A1 CL 2015002124A1 CL 2015002124 A CL2015002124 A CL 2015002124A CL 2015002124 A CL2015002124 A CL 2015002124A CL 2015002124 A1 CL2015002124 A1 CL 2015002124A1
- Authority
- CL
- Chile
- Prior art keywords
- modulators
- nmda receptors
- spiro
- lactam nmda
- lactam
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
COMPUESTOS HETEROCICLOS DERIVADOS DE ESPIRO-LACTAMAS, MODULADORES DE LOS RECEPTORES NMDA; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE; UTILES PARA TRATAR ENFERMEDADES TALES COMO TRASTORNO DE DEFICIT ATENCIONAL, DEPRESION, ANSIEDAD, ENTRE OTRAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361757939P | 2013-01-29 | 2013-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015002124A1 true CL2015002124A1 (es) | 2015-12-04 |
Family
ID=50097881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015002124A CL2015002124A1 (es) | 2013-01-29 | 2015-07-29 | Moduladores de receptores nmda de espiro-lactama y sus usos |
Country Status (16)
Country | Link |
---|---|
US (2) | US9738650B2 (es) |
EP (1) | EP2951186B1 (es) |
JP (1) | JP2016506961A (es) |
KR (1) | KR20150110586A (es) |
CN (1) | CN105026401A (es) |
AU (1) | AU2014212490A1 (es) |
BR (1) | BR112015018095A2 (es) |
CA (1) | CA2899010A1 (es) |
CL (1) | CL2015002124A1 (es) |
EA (1) | EA201591404A1 (es) |
IL (1) | IL240165A0 (es) |
MX (1) | MX2015009778A (es) |
PE (1) | PE20151438A1 (es) |
PH (1) | PH12015501600A1 (es) |
SG (1) | SG11201505937SA (es) |
WO (1) | WO2014120789A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102186883B (zh) | 2008-09-18 | 2016-08-03 | 西北大学 | Nmda受体调节剂和其用途 |
AU2014212501A1 (en) | 2013-01-29 | 2015-07-30 | Aptinyx, Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
EP2951186B1 (en) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CA2898861C (en) | 2013-01-29 | 2021-07-20 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CN105408336B (zh) | 2013-01-29 | 2018-06-26 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
SG11201505934XA (en) | 2013-01-29 | 2015-09-29 | Naurex Inc | Spiro-lactam nmda receptor modulators and uses thereof |
WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CA3024606C (en) | 2016-05-19 | 2019-09-03 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CA3031539C (en) | 2016-08-01 | 2023-11-28 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
EP3490990B1 (en) | 2016-08-01 | 2023-12-06 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam nmda modulators and methods of using same |
BR112019001926A2 (pt) * | 2016-08-01 | 2019-08-06 | Aptinyx Inc | moduladores do receptor nmda espiro-lactama e bis-espiro-lactama e usos destes |
PE20190503A1 (es) * | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactam y uso de los mismos |
WO2018026763A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2019152685A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and methods of using same |
PE20210455A1 (es) | 2018-01-31 | 2021-03-08 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
WO2019152696A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
SG11202007251XA (en) * | 2018-01-31 | 2020-08-28 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
CN109485598A (zh) * | 2018-11-29 | 2019-03-19 | 河南师范大学 | 一种去除氨基上喹啉保护基的新方法 |
CN114599354A (zh) * | 2019-08-01 | 2022-06-07 | 阿普廷伊克斯股份有限公司 | 与nmda受体相互作用的抗体的水平升高相关性障碍的治疗方法 |
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CA2898861C (en) | 2013-01-29 | 2021-07-20 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
EP2951186B1 (en) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
AU2014212501A1 (en) | 2013-01-29 | 2015-07-30 | Aptinyx, Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
CN105408336B (zh) | 2013-01-29 | 2018-06-26 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
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-
2014
- 2014-01-29 EP EP14704255.0A patent/EP2951186B1/en active Active
- 2014-01-29 MX MX2015009778A patent/MX2015009778A/es unknown
- 2014-01-29 CA CA2899010A patent/CA2899010A1/en not_active Abandoned
- 2014-01-29 EA EA201591404A patent/EA201591404A1/ru unknown
- 2014-01-29 SG SG11201505937SA patent/SG11201505937SA/en unknown
- 2014-01-29 KR KR1020157021534A patent/KR20150110586A/ko not_active Application Discontinuation
- 2014-01-29 WO PCT/US2014/013626 patent/WO2014120789A1/en active Application Filing
- 2014-01-29 BR BR112015018095A patent/BR112015018095A2/pt not_active IP Right Cessation
- 2014-01-29 JP JP2015556102A patent/JP2016506961A/ja not_active Withdrawn
- 2014-01-29 CN CN201480006688.2A patent/CN105026401A/zh active Pending
- 2014-01-29 US US14/764,419 patent/US9738650B2/en active Active
- 2014-01-29 AU AU2014212490A patent/AU2014212490A1/en not_active Abandoned
- 2014-01-29 PE PE2015001565A patent/PE20151438A1/es not_active Application Discontinuation
-
2015
- 2015-07-20 PH PH12015501600A patent/PH12015501600A1/en unknown
- 2015-07-27 IL IL240165A patent/IL240165A0/en unknown
- 2015-07-29 CL CL2015002124A patent/CL2015002124A1/es unknown
-
2017
- 2017-07-19 US US15/653,738 patent/US10253032B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20150376195A1 (en) | 2015-12-31 |
SG11201505937SA (en) | 2015-09-29 |
JP2016506961A (ja) | 2016-03-07 |
US20180155354A1 (en) | 2018-06-07 |
CN105026401A (zh) | 2015-11-04 |
EP2951186A1 (en) | 2015-12-09 |
CA2899010A1 (en) | 2014-08-07 |
IL240165A0 (en) | 2015-09-24 |
US9738650B2 (en) | 2017-08-22 |
WO2014120789A1 (en) | 2014-08-07 |
EA201591404A1 (ru) | 2016-01-29 |
EP2951186B1 (en) | 2018-07-25 |
MX2015009778A (es) | 2016-02-09 |
AU2014212490A1 (en) | 2015-07-30 |
US10253032B2 (en) | 2019-04-09 |
BR112015018095A2 (pt) | 2017-07-18 |
PE20151438A1 (es) | 2015-10-10 |
KR20150110586A (ko) | 2015-10-02 |
PH12015501600A1 (en) | 2015-10-19 |
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