CL2011000109A1 - Formulacion farmaceutica que comprende 30-70% de etilester del acido n-(2-amino-4-(fluorobencilamino)-fenil)carbamico (retigabina), 5-30% de una matriz que comprende hidroxipropilmetilcelulosa, 1,0-10% de un tensoactivo anionico y un polimero enterico; y su uso para tratar un trastorno de hiperexitabilidad del sistema nervioso. - Google Patents

Formulacion farmaceutica que comprende 30-70% de etilester del acido n-(2-amino-4-(fluorobencilamino)-fenil)carbamico (retigabina), 5-30% de una matriz que comprende hidroxipropilmetilcelulosa, 1,0-10% de un tensoactivo anionico y un polimero enterico; y su uso para tratar un trastorno de hiperexitabilidad del sistema nervioso.

Info

Publication number
CL2011000109A1
CL2011000109A1 CL2011000109A CL2011000109A CL2011000109A1 CL 2011000109 A1 CL2011000109 A1 CL 2011000109A1 CL 2011000109 A CL2011000109 A CL 2011000109A CL 2011000109 A CL2011000109 A CL 2011000109A CL 2011000109 A1 CL2011000109 A1 CL 2011000109A1
Authority
CL
Chile
Prior art keywords
hyperexitability
retigabine
fluorobenzylamino
disorder
treat
Prior art date
Application number
CL2011000109A
Other languages
English (en)
Inventor
Biljana Nadjsombati
Original Assignee
Valeant Pharmaceuticals Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41550741&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011000109(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Valeant Pharmaceuticals Int filed Critical Valeant Pharmaceuticals Int
Publication of CL2011000109A1 publication Critical patent/CL2011000109A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Formulación farmacéutica que comprende 30-70% de etil ester del ácido n-(2-amino-4-(fluorobencilamino)-fenil)carbámico (retigabina), 5-30% de una matriz que comprende hidroxipropilmetilcelulosa, 1,0-10% de un tensoactivo aniónico y un polímero entérico; y su uso para tratar un trastorno de hiperexitabilidad del sistema nervioso.
CL2011000109A 2008-07-18 2011-01-18 Formulacion farmaceutica que comprende 30-70% de etilester del acido n-(2-amino-4-(fluorobencilamino)-fenil)carbamico (retigabina), 5-30% de una matriz que comprende hidroxipropilmetilcelulosa, 1,0-10% de un tensoactivo anionico y un polimero enterico; y su uso para tratar un trastorno de hiperexitabilidad del sistema nervioso. CL2011000109A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8216208P 2008-07-18 2008-07-18

Publications (1)

Publication Number Publication Date
CL2011000109A1 true CL2011000109A1 (es) 2011-11-25

Family

ID=41550741

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011000109A CL2011000109A1 (es) 2008-07-18 2011-01-18 Formulacion farmaceutica que comprende 30-70% de etilester del acido n-(2-amino-4-(fluorobencilamino)-fenil)carbamico (retigabina), 5-30% de una matriz que comprende hidroxipropilmetilcelulosa, 1,0-10% de un tensoactivo anionico y un polimero enterico; y su uso para tratar un trastorno de hiperexitabilidad del sistema nervioso.

Country Status (16)

Country Link
US (1) US20100120906A1 (es)
EP (1) EP2318001A4 (es)
JP (1) JP2011528666A (es)
KR (1) KR20110052641A (es)
CN (1) CN102170879B (es)
AU (1) AU2009270768A1 (es)
BR (1) BRPI0916000A2 (es)
CA (1) CA2731008A1 (es)
CL (1) CL2011000109A1 (es)
CO (1) CO6351716A2 (es)
EA (1) EA201170230A1 (es)
IL (1) IL210683A0 (es)
MX (1) MX2011000636A (es)
NZ (1) NZ590885A (es)
WO (1) WO2010009433A1 (es)
ZA (1) ZA201102518B (es)

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DE102009013613A1 (de) * 2009-03-17 2010-09-23 Ratiopharm Gmbh Trockenverarbeitung von Retigabin
DE102009013612A1 (de) * 2009-03-17 2010-09-23 Ratiopharm Gmbh Retigabin-Tabletten, bevorzugt mit modifizierter Freisetzung
WO2011055385A1 (en) * 2009-11-03 2011-05-12 Lupin Limited Modified release formulation of lacosamide
EA201290663A1 (ru) * 2010-01-20 2013-03-29 Вэлиант Фармасьютикалс Интернешнл Состав с модифицированным высвобождением и способы применения
EP2525788A2 (en) 2010-01-20 2012-11-28 Glaxo Group Limited Novel retigabine composition
WO2012098075A1 (en) 2011-01-18 2012-07-26 Glaxo Group Limited Process for the preparation of retigabine
AU2016328150B2 (en) 2015-09-23 2020-10-01 Xw Laboratories Inc. Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
EP3397253A1 (en) 2015-12-30 2018-11-07 Adamas Pharmaceuticals, Inc. Methods and compositions for the treatment of seizure-related disorders
EP4069201A1 (en) * 2019-12-02 2022-10-12 Xenon Pharmaceuticals Inc. Pediatric immediate-release formulation of the potassium channel opener ezogabine

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Also Published As

Publication number Publication date
ZA201102518B (en) 2012-06-27
EP2318001A1 (en) 2011-05-11
MX2011000636A (es) 2011-08-03
CO6351716A2 (es) 2011-12-20
CN102170879A (zh) 2011-08-31
JP2011528666A (ja) 2011-11-24
BRPI0916000A2 (pt) 2019-09-24
EA201170230A1 (ru) 2011-08-30
CN102170879B (zh) 2014-03-05
NZ590885A (en) 2013-01-25
CA2731008A1 (en) 2010-01-21
US20100120906A1 (en) 2010-05-13
AU2009270768A1 (en) 2010-01-21
KR20110052641A (ko) 2011-05-18
WO2010009433A1 (en) 2010-01-21
EP2318001A4 (en) 2013-02-20
IL210683A0 (en) 2011-03-31

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