CL2009001330A1 - Compounds derived from cyano-3-oxoisoindoline-1-carboxamide, modulators of the sodium channel nav1,7; pharmaceutical composition comprising said compounds; and use in the treatment of a pain disorder. - Google Patents

Compounds derived from cyano-3-oxoisoindoline-1-carboxamide, modulators of the sodium channel nav1,7; pharmaceutical composition comprising said compounds; and use in the treatment of a pain disorder.

Info

Publication number
CL2009001330A1
CL2009001330A1 CL2009001330A CL2009001330A CL2009001330A1 CL 2009001330 A1 CL2009001330 A1 CL 2009001330A1 CL 2009001330 A CL2009001330 A CL 2009001330A CL 2009001330 A CL2009001330 A CL 2009001330A CL 2009001330 A1 CL2009001330 A1 CL 2009001330A1
Authority
CL
Chile
Prior art keywords
compounds
nav1
carboxamide
modulators
cyano
Prior art date
Application number
CL2009001330A
Other languages
Spanish (es)
Inventor
Yevgeni Besidski
Kristofer Ahlin
I Per Arvidsson
Linda I Nilsson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CL2009001330A1 publication Critical patent/CL2009001330A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos derivados de ciano-3-oxo-isoindolin-1-carboxamida, moduladores del canal de sodio nav1,7; composición farmacéutica que comprende dichos compuestos; y uso en el tratamiento de un trastorno de dolor.Compounds derived from cyano-3-oxo-isoindoline-1-carboxamide, modulators of the sodium channel nav1,7; pharmaceutical composition comprising said compounds; and use in the treatment of a pain disorder.

CL2009001330A 2008-05-30 2009-05-29 Compounds derived from cyano-3-oxoisoindoline-1-carboxamide, modulators of the sodium channel nav1,7; pharmaceutical composition comprising said compounds; and use in the treatment of a pain disorder. CL2009001330A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5731908P 2008-05-30 2008-05-30

Publications (1)

Publication Number Publication Date
CL2009001330A1 true CL2009001330A1 (en) 2010-01-15

Family

ID=41377344

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009001330A CL2009001330A1 (en) 2008-05-30 2009-05-29 Compounds derived from cyano-3-oxoisoindoline-1-carboxamide, modulators of the sodium channel nav1,7; pharmaceutical composition comprising said compounds; and use in the treatment of a pain disorder.

Country Status (6)

Country Link
AR (1) AR071956A1 (en)
CL (1) CL2009001330A1 (en)
PE (1) PE20091947A1 (en)
TW (1) TW201000447A (en)
UY (1) UY31853A (en)
WO (1) WO2009145719A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013007768A1 (en) 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
WO2015102929A1 (en) * 2013-12-30 2015-07-09 Novartis Ag Tricyclic sulfonamide derivatives
US11046683B2 (en) 2016-12-15 2021-06-29 Ono Pharmaceutical Co., Ltd. Activator of TREK (TWIK RElated K+ channels) channels
CA3147397A1 (en) 2019-07-22 2021-01-28 Lupin Limited Macrocyclic compounds as sting agonists and methods and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
TW200804281A (en) * 2006-02-16 2008-01-16 Astrazeneca Ab New metabotropic glutamate receptor-potentiating isoindolones
US20090291983A1 (en) * 2006-07-12 2009-11-26 Astrazeneca Ab 3-Oxoisoindoline-1-Carboxamide Derivatives as Analgesic Agents
TW200812962A (en) * 2006-07-12 2008-03-16 Astrazeneca Ab New compounds I/418
GB0705882D0 (en) * 2007-03-27 2007-05-02 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
WO2009145719A1 (en) 2009-12-03
TW201000447A (en) 2010-01-01
UY31853A (en) 2010-01-05
AR071956A1 (en) 2010-07-28
PE20091947A1 (en) 2010-01-28

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