CL2009000721A1 - Combination comprising an isolated anti-igf1r antibody or an antigen-binding fragment thereof in association with leucovorin and 5-fluorouracil, leucovorin or sunitinib optionally associated with another chemotherapeutic agent; and its use for the treatment or prevention of colorectal cancer. - Google Patents

Combination comprising an isolated anti-igf1r antibody or an antigen-binding fragment thereof in association with leucovorin and 5-fluorouracil, leucovorin or sunitinib optionally associated with another chemotherapeutic agent; and its use for the treatment or prevention of colorectal cancer.

Info

Publication number
CL2009000721A1
CL2009000721A1 CL2009000721A CL2009000721A CL2009000721A1 CL 2009000721 A1 CL2009000721 A1 CL 2009000721A1 CL 2009000721 A CL2009000721 A CL 2009000721A CL 2009000721 A CL2009000721 A CL 2009000721A CL 2009000721 A1 CL2009000721 A1 CL 2009000721A1
Authority
CL
Chile
Prior art keywords
leucovorin
sunitinib
fluorouracil
antigen
association
Prior art date
Application number
CL2009000721A
Other languages
Spanish (es)
Inventor
Yaolin Wang
Ming Liu
Yan Wang
Walter Robert Bishop
Cynthia Seidel-Dugan
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of CL2009000721A1 publication Critical patent/CL2009000721A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Combinación que comprende un anticuerpo aislado anti-igf1r o un fragmento de fijación de antígeno del mismo en asociación con leucovorina y 5-fluorouracilo, leucovorina o sunitinib opcionalmente asociado con otro agente quimioterapéutico; y su uso para el tratamiento o prevención del cáncer colorectal.Combination comprising an isolated anti-igf1r antibody or an antigen-binding fragment thereof in association with leucovorin and 5-fluorouracil, leucovorin or sunitinib optionally associated with another chemotherapeutic agent; and its use for the treatment or prevention of colorectal cancer.

CL2009000721A 2008-03-25 2009-03-24 Combination comprising an isolated anti-igf1r antibody or an antigen-binding fragment thereof in association with leucovorin and 5-fluorouracil, leucovorin or sunitinib optionally associated with another chemotherapeutic agent; and its use for the treatment or prevention of colorectal cancer. CL2009000721A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3919708P 2008-03-25 2008-03-25

Publications (1)

Publication Number Publication Date
CL2009000721A1 true CL2009000721A1 (en) 2010-05-14

Family

ID=41340744

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009000721A CL2009000721A1 (en) 2008-03-25 2009-03-24 Combination comprising an isolated anti-igf1r antibody or an antigen-binding fragment thereof in association with leucovorin and 5-fluorouracil, leucovorin or sunitinib optionally associated with another chemotherapeutic agent; and its use for the treatment or prevention of colorectal cancer.

Country Status (8)

Country Link
US (1) US20110104256A1 (en)
EP (1) EP2259797A2 (en)
JP (1) JP2011515478A (en)
CA (1) CA2718918A1 (en)
CL (1) CL2009000721A1 (en)
MX (1) MX2010010480A (en)
TW (1) TW200944233A (en)
WO (1) WO2009142810A2 (en)

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CN102886045A (en) 2005-02-03 2013-01-23 综合医院公司 Method for treating gefitinib resistant cancer
EP1942937A1 (en) 2005-11-04 2008-07-16 Wyeth Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
PL2310011T3 (en) 2008-06-17 2013-12-31 Wyeth Llc Antineoplastic combinations containing hki-272 and vinorelbine
SG10202102855RA (en) 2008-08-04 2021-05-28 Wyeth Llc Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
CN104042612A (en) 2008-11-11 2014-09-17 得克萨斯大学体系董事会 Inhibition Of Mammalian Target Of Rapamycin
CN102481299B (en) 2009-02-12 2015-02-25 艾科尔公司 A composition comprising (-) -trans-3- (5, 6-dihydro-4h-pyrrolo [3,2,1-ij] quinolin-l-yl)-4-(lh-indol-3-yl) pyrrolidine- 2, 5-dione in combination with a second anti-proliferative agent
MX356593B (en) 2009-04-06 2018-06-05 Wyeth Llc Treatment regimen utilizing neratinib for breast cancer.
US9283211B1 (en) 2009-11-11 2016-03-15 Rapamycin Holdings, Llc Oral rapamycin preparation and use for stomatitis
WO2012003421A2 (en) * 2010-07-01 2012-01-05 Arqule, Inc. Combinational compositions and methods for treatment of cancer
US9141756B1 (en) 2010-07-20 2015-09-22 University Of Southern California Multi-scale complex systems transdisciplinary analysis of response to therapy
TW201221126A (en) 2010-09-01 2012-06-01 Arqule Inc Methods for treatment of non-small cell lung cancer
NL2010276C2 (en) * 2013-02-08 2014-08-11 Stichting Vu Vumc Biomarkers.
US20150141273A1 (en) * 2012-04-26 2015-05-21 Stichting Vu-Vumc Biomarkers
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
US20160030401A1 (en) 2013-03-13 2016-02-04 The Board Of Regents Of The University Of Texas System Use of mtor inhibitors for prevention of intestinal polyp growth and cancer
US9700544B2 (en) 2013-12-31 2017-07-11 Neal K Vail Oral rapamycin nanoparticle preparations
AU2014373683B2 (en) 2013-12-31 2020-05-07 Rapamycin Holdings, Llc Oral rapamycin nanoparticle preparations and use
JP6210640B2 (en) * 2014-06-19 2017-10-11 大原薬品工業株式会社 Hololinate calcium-containing tablets
WO2016054055A1 (en) * 2014-09-29 2016-04-07 Board Of Regent, The University Of Texas System Prediction of response to parp inhibitors and combinational therapy targeting c-met and parp1
JP2018517892A (en) 2015-04-10 2018-07-05 アプライド プロテオミクス，インク． Protein biomarker panel to detect colorectal cancer and advanced adenoma
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
SI3337467T1 (en) 2015-08-20 2021-03-31 Ipsen Biopharm Ltd. Ash Road Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment
EP3791876A1 (en) 2015-08-21 2021-03-17 Ipsen Biopharm Ltd. Methods for treating metastatic pancreatic cancer using combination therapies comprising liposomal irinotecan and oxaliplatin
WO2017136671A1 (en) * 2016-02-04 2017-08-10 Chattterjee Bandana Combination therapy for castration-resistant prostate cancer
SG11201903615WA (en) 2016-11-02 2019-05-30 Ipsen Biopharm Ltd Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin)
JP2017210493A (en) * 2017-09-08 2017-11-30 大原薬品工業株式会社 Calcium folinate-containing tablet
CN113164480B (en) * 2018-11-14 2023-11-28 学校法人金泽医科大学 Pharmaceutical composition for treating diffuse gastric cancer
JP2021036003A (en) * 2020-12-05 2021-03-04 大原薬品工業株式会社 Calcium folinate-containing tablet

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Also Published As

Publication number Publication date
WO2009142810A2 (en) 2009-11-26
MX2010010480A (en) 2010-10-15
CA2718918A1 (en) 2009-11-26
EP2259797A2 (en) 2010-12-15
TW200944233A (en) 2009-11-01
WO2009142810A3 (en) 2010-07-15
JP2011515478A (en) 2011-05-19
US20110104256A1 (en) 2011-05-05

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